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Query: gi|60682029|ref|YP_212173.1| putative bifunctional CbiF/CbiG cobalamin biosynthesis protein (BF2549) [Bacteroides fragilis NCTC 9343] (Range: 1-599), from B.fragilis

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MKTAIIVISEAGIALAKTLEQELPESEIFSTGTDTDCHSISNLQEAVPEIFHKFDAIIFIGAMGICIRAIAPHIEDKHKDPAVVCVDSTGRYAVSVLSGHIGGANGLTRYVASILGAEPVITTRSDRTGLWALDTLGKKYGWQTVPAESSDMNHLITLFVDCKPTALLLDIRDEGTTQLEHTLPPHVDVFYKFEDMDLRKYDLLLLVTPFIYNTSDTPALYYVPPVLHMGVGLARDAHPVDTVITHLMDVVVQANMIPLAIRTVSSIEEKKDEPVLKLLAEAYQTRLYTASQLSKIEVPTPSEVVNKHMGTPSVSEASALLSSGGGPLLLPKQKGANFTVAIAMDAASVRQGHIEIVGAGPGDPELISVRGRHFLEEADLILYAGSLVPRELTECAKAGATIRSSASMTLEEQFALMKEFYDRGQLVVRLHTGDPCIYGAIQEQMNFFDQYGMHYHITPGISSFQAAAAALQSQFTIPERVQTIILTRGEGRTPMPEKEKLSLLARSQSTMCIFLSAGVVDQVQRELLEHYPPTTPVAACYHLTWKDERIFRGQLQDLAKIVNENHLTLTTMIVVGDAIDNREGLSRLYSHQFKHLFRKLast
1 -74.800[H] COG2073 Cobalamin biosynthesis protein CbiG  ali follow..  26  1MIVTILTLTERARRLAGEMREKLLRDPTILSV------EVMHRNMDLGNVFAESDIIVGIMAAGIMVRKIAPLINNKLSDPGVLVVDEKGSNVISLLSGHAGGANDFAIKLAGLIGANPVITTSTDVNGLVGIDTFAARYFYRIL--DPHLIRHFNSSIIQGHRVELHSSRDLE----------------ALIDDDMRRTYTYVPEGDEVVRAHCNSRVMRLAPLKLSMGIGTRRGV-GSDRVIGLIRETLKLLKIPPERLDAIATGYMKRDEDGIREAARLLGVPLIGPQELRSQNTLSFSDFVYEKFGVGSVCEAAALSSAGDSKLVIRKTKSSGVTAALAVSG............................................................................................................................................................................................................................................................. 324
2 -69.600[H] COG2875 Precorrin-4 methylase  ali follow..  45  1....................................................................................................................................................................................................................................................................................................................................................................MGAGPGDPELITLKAVRALRGADVVIYAGSLVNRDILEYAPEDAEVHNSAHMNLEEITDIMVEACRAGKTVARVHTGDPSIYGAIKEQIRVLEKNSIPYTIIPGVSSVFAAAATLNTELTLPEVSQTVIITRPAGRTPVPPGEDLEELAVHGSTMCIFLGVHMIEDVAEKLMTHYPPDTPVAVVKRASWPDEEVVRGTLSDIAERVRAAGISKTAMIIVGSVLEPGDFKPSLYDAGFSHEYRP 244
3 -58.200[H] COG1010 Precorrin-3B methylase  ali follow..  17  2..............................................................................................................................................................................................................................................................................................................................................................RGRLRIVGIGPGDPSVRTFRAVEAIKESEVVVGYETYIG--LIKDLLEGKEVIPAKMRQEIFRAEISISKALEGRKVALVSDGDPNVYGMAPLVFELMAKRGVDVEVIPGVTAALAAAAKLGAPLGS----DFAVINLSDLLTPREAILRVKAAAEADFVLVFYNPIDS-KAALEVVRSVRGDSTPVGLVKNAYRQGEEVRITALGEV----DMDWIDMRTTIIVGNSETFTWR-GYLITPRGY..... 239
4 -54.700[H] COG0007 Uroporphyrinogen-III methylase  ali follow..  24  23.............................................................................................................................................................................................................................................................................................................................................................EPGHVWLVGAGPGDPGLLTLHAVNALQQADVIV-YDALVDDSCLSLKNATATLEYAPSPRQRDISLRLVELARQGKKVLRLKGGDPFVFGRGAEEALTLVEYHVPFRIVPGVTAGVGGLAYAGIAATHRDINQAVTFLTGHDATG-PDGVDWAGIARSSPVIVMYMAMKHIGLIAGRLIEGRSPDEPVAFVCNASLPDQTVLETTLGRAAIEVEAAGLQPPAIVVVGEVVRLRAGLDWI-----GAMAGK 274
5 -46.600[H] KOG1527 Uroporphyrin III methyltransferase  ali follow..  16  3...................................................................................VSWSLKDAVVV------VGSGKNAYRRVNLCLSENSSKIFWFC-RSSADGGFDVGHLQLDAKKSDAIEILPISEFDPVRSLTTLGKEETDFLVDAVFVSESNHHEKEILHRTCKRYRIPLNIIDNPSLCSFTLPATWSEPPLQISLSTS-SNGCRLAQRLLRHVVSSLPSG---MPEAIERFGRVRAITKTPEKKQWINHVSDFWPLEKLVRMTEDDLLAIVSDNFSLPLSSSQSSSLANSYES--LSTTLDKPSLTLDPEAFPTHKRGSIALIGSGPGSPDLLTVAARKAIMKADYVL-ADKLVPEAVLQLIPRHTPLFIAADKAQDELHQVAFDALSRGDYVVRLKQGDPYIYGRGGEEYLFFTQHGYVPTVIPGISSALMAPISAGIPVTHRGVADQFLVCTGTGQK--GSMPKIPSFVPTQ-TTVFLMALHRLEILVQALIEGWPRVLPVCIAERVSCPDQRFIFSTLEDVVEEYNKYESLPPGLLITGYSCNTLRNTA............. 496
6 -43.900[H] COG2243 Precorrin-2 methylase  ali follow..  16  1.....................................................................................................................................................................................................................................................................................................................................................MNALPNANSRGKLVGVGTGPGDPELLTLKAARALAEADVVAYVEARFRPDMLELPLLYPVTTEIDKDHYEESAQKVAEHLEAGKMVAVLSEGDPLFYGSYMHLHVRLAH-RFPTEVIPGITAMSGCWSQTGVPIVQGDDVLTVLPGTMS-------EFELTRRLADTDAAVIMKVGRNLPKIRRALEV-TGKLTRAVYVERGTMAGSVSTK------LADKRDDKAPYFAIILVAGWSGRPGALGA............ 254
7 -41.400[H] COG2241 Precorrin-6B methylase 1  ali follow..  22  2.................................................................................................................................................................................................................................................................................................................................................................IYVIGAGPGDPSMIPLKALEILKKCPLVMGWRNVV-DKLREYIKGEVVYL-----TYTNQEEILQKYLKTEGDVCIITHGDPCVSDWE--FLERIKAFKADVVVINGVSSLNVALARLGLDMAH------IVFATLHARSPQDLRPLVAILHHRVLIAFPYPTADGPQRLARELIALGATGCKATVLENLTLKDERIWQGGLEELSRETR--HFSDLSVVAVDCRGSS.................. 213
8 -38.200[J] COG1798 Diphthamide biosynthesis methyltransferase  ali follow..  13  3.................................................................................................................................................................................................................................................................................................................................................................LYFIGLGLYDERDITVKGLEIAKKCDYVF-AEFYTSLMAGTTLGRIQKLIGKEIRVELNFENIVLPLA-KENDVAFLTPGDPLVATTHAELRIRAKRAGVESYVIHAPSIYSAVGI-TGLHIYKFGKSATVAYPEGNWFPGLHTLLFLDIKAEKRMYMTANEAMELLLKVEDMKKGGFTDDTLVVVLARAGSLNPTIRAGYVKDLIR--EDFGDPPHILIVPGKLHIVEAE............... 248
9 -37.300[J] KOG3123 Diphthine synthase  ali follow..  16  2.................................................................................................................................................................................................................................................................................................................................................................LYLIGLGLGDAKDITVKGLEVVRRCSRVYLYTSVLTVGKEALEEFYGRKLVVADREEVEQEADNILKDADISDVAFLVVGDPFGATTHSDLVLRATKLGIPYRVIHNASIMNAVGC-CGLQLYKFGETVSIMLISVMLHSLWENLIKGRKIYEPPRYMSVNQAAQQLLEIVQNQRIRVTEETLCVGLARVGADDQKIAAGTLRQMCTV--DLGEPLHSLIITGGSIHPMEM............... 276
10 -23.400[R] COG0313 Predicted methyltransferases  ali follow..  15  12...............................................................................................................................................................................................................................................................................................................................................................PILYIVPTPIGNLGDITQRALDVLASVDMIAVEDTRHTGKLLAHFNISTKTFALHDHNEQQKAQVLVDKLLSGLSIALVSAGTPLISDPGYHLVTQCRQAGVKVVPLPGPCAVITALSASGLP------SDSFSFEGFLPAKSKARKDKLLEIAKVSRTCIFYESPHRICESLQDMLDVLGGEREVVLARELTKTFETIQGMPLAELITWIAEDDNRKKGEMVL........................ 230
11 -10.000[R] COG3956 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain  ali follow..  19  2..............................................................................................................................................................................................................................................................................................................................................................AGKITVVGLGAGDMDQLTIGIHKLLTKAD--LYVRTKDHPLIEELEKETKNIRFFDDIYEEEIADILFEAARREDVVYAV--GHPFV-KTVQLLTERQEKENVQVKVAGGQSFLDATFNVLQI-----DPIEGFQFVDAGTLSADELE------LRHHLIICQVYDQMTASEVKLTLMEKLPDDYEVVIVTAAGSRGEEIRTVPLFELDRNVALNNLTSVYIPPIKEEKLLYHEFSTFRS......... 238

FFAS is supported by the NIH grant R01-GM087218-01
1 2 6 4 6 7   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Rodrigues AP, Grant BJ, Godzik A, Friedberg I. The 2006 automated function prediction meeting. BMC Bioinformatics. 2007 May 22;8 Suppl 4:S1-4.