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Query: gi|60682477|ref|YP_212621.1|(removed signalp:1-23) hypothetical protein (BF3007) [Bacteroides fragilis NCTC 9343] (Range: 24-588), from B.fragilis

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst CYSTPDGVMSSLSQAEKIMESRPDSAMAILQHIPTPETLHGKAQADYSLLMTQAMDKNYINFTSDSLIKFAVGYYGGHTEDLVAKGKSFYYYGRVMESLDKVEDAMTFYLKAKDVLQSSDQFKLLGLVTEKIGDLNRRQKLLDAALNDYKESFDFYASIPDSLCMLYAYRNLGRGFLYKNQIDSAYYYYDKALYILNLKKYSAVGSILLELGVIHRSEKDYVGAEQYFLSFIEKEKDPEKLFSGYLALGNLYLYMDRLKDAERYLLLCLGSSNLVIKRDACECLYDLEKELNNFKGAIGYKDIADSLRIITQDIDIQNSIATLQSRYNSEKWQRESLQSSIEKKNILLISSFVSFIAIMVIIYIYYKYRTNQKLVKDINERIRKNDADIKMYQRQILNYQDLQRETLQDYRNQIGELHGKMSVLEDQNKALSLRLTEKKHDIPESEADDLYAIYMQALHILIMLRGKNIENTSGKKLLLDADWDKLFHLSNAIHGDFITRIKNDFPTLTKHDIEICCLLRFGIEHEVLGSIFLTETDSVTKAKRRMKKRLNLSASDDLDVFLLKYLast
1 -41.200[T] KOG1130 Predicted G-alpha GTPase interaction protein, contains GoLoco domain  ali follow..  12  51.LKTLSAIYSQLGNAYFYLHDYAKALEYHHHDLTLARTIGDQLGEAKASGNLGNTLKVLGNFDEAIVCCQRHLDISRELNDKVGEARALYNLGNVYHAKGKLQAAVDFYEENLSLVTALGDRAAQGRAFGNLGNTHYLLGNFRDAVIAHEQRLLIAKEFGDKAAERRAYSNLGNAYIFLGEFETASEYYKKTLLLAQLKDRAVEAQSCYSLGNTYTLLQDYEKAIDYHLKHLQELNDRIGEGRACWSLGNAYTALGNHDQAMHFAEKHLEVGDKSGELTARLNLSDLQMVLGSYSTNNSIMSENTEIDSSLNGVLKLGRRHSMENMELMKLTPEKVQNWNSEI--------------------------AKQKPLIAKPSAKLLFVNRLKGKKYKTNSSTKVLQDASNSIDHRIPNSQRKISADTIGDEGFFDLLSRFQSNRMDDQRCCLQEKNCHTASTTTSSTPPKMMLKTSSVPVVSPNTDEFLDLLASSQSRRLDDQRASFSNLEADEDFFDILVKCQGSRLDFSLILRSQGKRMDEQRVLLQRDQNRDTDFGLKDFLQN. 661
2 -36.500[U] KOG1586 Protein required for fusion of vesicles in vesicular transport, alpha-SNAP  ali follow..  31..........................................................................LFGGSSKIEEACEIYARAANMFKMAKNWSAAGNAFCQAAQLHLQLQSKHDAATCFVDAGNAF-KKADPQEAINCLMRAIEIYTDMGRFTIAAKHHISIAEIYTELVDIEKAIAHYEQSADYYKGEESNSANKCLLKVAGYAALLEQYQKAIDIYEQVGTNAMDLKYSAKDYFFKAALCHFCIDMLNAKLAVQKYEELFPAFSDSRECKLMKKLEQNVDSYTESVKEYDSISRLDQWL-----TTMLLRIKKTIQGDEEDLR...................................................................................................................................................................................................................................... 295
3 -32.700[Z] KOG1840 Kinesin light chain  ali follow..  12  283...........LAEALVQALRFDEAQQVCETALSIHRESPGSIAEAADRRLMGLICETKGDHENALEHLVLASMAMAANGQESEVAFVDTSIGDSYLSLSRFDEAICAYQKSLTALKTAENHPAVGSVYIRLADLYNRTGKVREAKSYCENALRIYESHISPEEIASGLTDISVICESMNEVEQAITLLQKALKIYADGQKIMIAGIEAQMGVLYYMMGKYMESYNTFKSAISKLRQSTFFGIALNQMGLACIQLDAIEEAVELFEEAKCIPYHPETLGLYSNLAGAYDAIGRLDDAIKLLGHVVGVREEKLGTANEDEKRRLAQLLKEAGNVTGRKAKSLKT.............................................................................................................................................................................................................................. 637
4 -31.800[DO] KOG1173 Anaphase-promoting complex (APC), Cdc16 subunit  ali follow..  14  406.....GDFNRLFYVAHKLVDRYPDKAI--------------------SWYAVGCYYDMIGKSDPARRYLSKATALDRL-------GPAWLAYGHSFANENEHEQAMAAYFKATQLMRGC------HLPLLYIGVECGLTKNLELAEKFFLQAMNIAPL-------VYVLHELGVIKYEYEFFDGAATIFQCTVDIVKQRAKSN-EPLFINLGHSLRKVHKYEEALYNFQYALLLKPQS---PTTYTSIGFIHALLGNLDPAIEAFHKSLALN---DCIVTSTILKSCIEDLMDDSATIDEICSAALRDVAKNITANSRRVLNSDKFNGMKLKFDEEEEFANSD.............................................................................................................................................................................................................................. 707
5 -30.600[D] KOG1126 DNA-binding cell division cycle control protein  ali follow..  13  345...................................................................LREALNCFQSLPIEQQNTPFVLAKLGITYFELVDYEKSEEVFQKLRDLSPSR------VKDMEVFSTALWHLQKSVPLSYLAHETLETNPYS------PESWCILANCFSLQREHSQALKCINRAIQL-----DPTFEYAYTLQGHEHSANEEYEKSKTSFRKAIRVNVRH---YNAWYGLGMVYLKTGRNDQADFHFQRAAEINPNN--SVLITCIGMIYERCKDYKKALDFYD....................................................................................................................................................................................................................................................................... 557
6 -30.500[NU] COG3063 Tfp pilus assembly protein PilF  ali follow..  14  21......................................................................STSYRPSRAEKANQVSNIKTQLAMEYMRGQDYRQATASIEDALKSDPKNEL------AWLVRAEIYQYLKVNDKAQESFRQALSIKPDSAE------INNNYGWLCGRLNRPAESMAYFDKALADPTYPTP---YIANLNKGICSAKQGQFGLAEAYLKRSLAAQPQF---PPAFKELARTKMLAGQLGDADYYFKKYQSRVEVLQADDLLLGW-KIAKALGNAQAAYEYEAQLQA................................................................................................................................................................................................................................................................... 238
7 -30.400[DO] KOG1155 Anaphase-promoting complex (APC), Cdc23 subunit  ali follow..  12  251.....RMHTESLAKYEYLQGIFSFSNYIQAQTAKAQYSLREFDQVEIMFEELEDMDLYSNVLYAKEACAALSYLAHKVFLTDKYRPESCCIIGNYYSLKGQHEKAVMYFRRALKLNKKY------LSAWTLMGHEYVEMKNTPAAIDAYRRAVDINPT-------YRAWYGLGQAYEMMGMPFYALHYFRKSIFFLPND-----SRLWIAMAKCYEQLYMLEEAIKCYKRAVNCTDTE---GIALNQLAKLHQKLGRNEEAAYYFEKDLERMDAEGLFEALVFLATHFKNHKKFEEAEVYCTRLLDYSGP--EKEKAKSLLRGIRMAQTGFPSMDLEHFPI................................................................................................................................................................................................................................ 579
8 -29.800[R] KOG1129 TPR repeat-containing protein  ali follow..  13  175...........LAKCYLRLGMLQDATKQLQSSLEQKKLIETFALLSKAYNRVD-------------QPMAALKTYSAGLEVFPENVTMLTGMARVQEALGEYDESVKLYKRVLDAESNNIE------AIACVATTYYYGGKPELAMRYYRRILQMGVSSPE------LFLNIGLCCMAAQQFDFALSSILRAQST---MTDDVAADVWYNIGQILVDIGDLVSAARSFRIALSHDPDH---SESLVNLGILKHREGKIDEARSLYSSATSKN---YMFEGNYNLGLVSFTQGKYHECRELIEKALAAFEHEHCKKILNHLKPLYES............................................................................................................................................................................................................................................... 457
9 -29.200[U] COG5010 Flp pilus assembly protein TadD, contains TPR repeats  ali follow..  16  55...............................................................NATELAAAAERIGQAYERNPKDREAGLNYANLLRMTGRNEQALAVMQQVAIYHPADRE------VLGAYGKAQAAAGQLEQALATISRAQTPDRP-------WKLKSAEGAILDQLGRSAEARLRYREALDLKPNE-----PSVLSNLGMSYLLTKDLRTAETYLKSAASQPDAG---SSVRQNLALAVGLQGRFQEAETIAGQELTSEQAEANV---AYLRSVLSQQGAWKQLAK.......................................................................................................................................................................................................................................................................... 267
10 -29.100[G] COG2956 Predicted N-acetylglucosaminyl transferase  ali follow..  12  35...................................................LSRDYVAGVNFLLSNQQDKAVDLFLDMLKEDTGTVEAHLTLGNLFRSRGEVDRAIRIHQTLMESASLTYEQR--LLAIQQLGRDYMAAGLYDRAEDMFNQLTDETDFR------IGALQQLLQIYQATSEWQKAIDVAERLVKLGKDKQRVEIAHFYCELALQHMASDDLDRAMTLLKKGAAADKNS---ARVSIMMGRVFMAKGEYAKAVESLQRVISQ-DRELVSETLEMLQTCYQQLGKTAEWAEFLQRAVEENTGADAELMLADIIEARDGSE............................................................................................................................................................................................................................................. 299
11 -27.800[R] COG4785 Lipoprotein NlpI, contains TPR repeats  ali follow..  12  39..............................................................QQEVILARMEQILASRALTDDERAQLLYERGVLYDSLGLRALARNDFSQALAIRPDMPE------VFNYLGIYLTQAGNFDAAYEAFDSVLEL------DPTYNYAHLNRGIALYYGGRDKLAQDDLLAFYQDDPNDPFRSLNIVEFYLGNI-SEQTLMERLKADATDNTSLAEH---LSETNFYLGKYYLSLGDLDSATALFKLAVANNVHNFVE--HRYALLELSLLGQDQDDLAESDQ...................................................................................................................................................................................................................................................................... 293
12 -27.000[S] KOG2796 Uncharacterized conserved protein  ali follow..  185.................................................................................RSRLGRVMYSMANCLLLMKDYVLAVDAYHSVIKYYPEQE-----PQLLSGIGRISLQIGDIKTAEKYFQDVEKVTQKLDGLQGKIMVLMNSAFLHLGQNNFAEAHRFFTEILRMDPRN-----AVANNNAAVCLLYLGKLKDSLRQLEAMVQQDPRHYLHESVLFNLTTMY-SSRSMQKKQALLEAVAGKEGDSFNTQCLK........................................................................................................................................................................................................................................................................................... 377
13 -26.800[U] KOG2376 Signal recognition particle, subunit Srp72  ali follow..  28...KDTKYEEAVKVADQVLSIVPTDEDAIRCKVVALIKDDKFDDYLIKDVKINGALSVINSFPIDLGFHKAYCLYRVCLKGLERESKTLLLEAQILNCLGKVDACVDVYQKLNKSGIKLIEVNLVAQLAYNTACSLIENSNYVDAEQLLLTAMRIGQETYIETQLAPISVQLAYVQQVLGQTQESKSSYVDIIKLDAKLSHKHKEAIYANRVLLLLHANKMDQARELCATLPGMFPES---VIPTLLQAAVLVRENKAAKAEELLGQCAE-NFPEKSKLVLLARAQIAASASHPHVAAESLS-------KIPDIQHLPATVATIVALRERAGDNDGATAVLDSAIRWWSDSMTDSNMLRILMPVAAAFKLRHGQEEEASRLYEEIVKNHNSTDALVGLVTTLARVNVEKAEAYEKQLKPLPGLKAVDVDNLEKTSGAKPIEGISAASLSQEEVKKEKVKRKRKPKYPKGFDLENSGPTPDPEW------------------------LPRRE------------------------RSSYRPKRKDKRA................ 602
14 -26.000[R] KOG0553 TPR repeat-containing protein  ali follow..  13  15....................................................................................LHDQLRHGGLSSDAQESLEVAIQCLETAFGV----TVEDSDLALPQTLPEIFEAAATGKEMPQDLRSPAR-TPPSEEDSAEAERLKTEGNEQMKVENFEAAVHFYGKAIEL-----NPANAVYFCNRAAAYSKLGNYAGAVQDCERAICIDPA----SKAYGRMGLALSSLNKHVEAVAYYKKALELD---DNETYKSNLKIAELKLREAPSPTG.......................................................................................................................................................................................................................................................................... 214
15 -25.600[S] KOG4340 Uncharacterized conserved protein  ali follow..  10  22.................IRDARYAEAVQLLGQLH-PELEQYRLYQAQALYKAC-------------LYPEATRVAFLLLDNPAYHSRVLRLQAAIKYSEGDLPGSRSLVEQLLSGEGGEESGG--TDGQVNLGCLLYKEGQYEAACSKFSATLQASGYQPD------LSYNLALAYYSSRQYASALKHIAEIIERTLVLHQTALVEAFNLKAAIEYQLRNYEVAQETLTDMPPRAEEELDPVETFGNLLLLYCKYEYFDLAADVLAENAHLTYKFLTPYLYDFLDALITCQTAPEEAFIKLDGLAMLTEQLRRLTKQVQEARHNRDDEAIKKAVNEYDETMEKYIPVLMAQAKIYWNLENYPMVEKVFRKSVEFCNDHDVWKLNVAHVLFMQENKYKEAIGFYEPIVKKMTSQNEEAEELMRKIEKEEEQLSYDDPNRKMYHLCIVNLVIGTLYCAKGNYEFGISRVIKSLEPYNKKLGTDTWYYAKRCFLSLLENMSKHMIVIHDSVIQECVQF--LGHCELYGTNIPAVMHVGKNTVTDESRQLKALI-----------IIGW 626
16 -24.800[R] KOG1124 FOG: TPR repeat  ali follow..  10  251.....GNVRRARELFDAATVADKKHVAAWHGWANLEIKQGNISKARNLLAKGLKFCGRNEYEAKAGRYEQARYLFKQATICNSRSCASWLAWAQLEIQQERYPAARKLFEKAVQASPKNRF------AWHVWGVFEAGVGNVERGRKLLKIGHALNPR-------PVLLQSLGLLEYKHSSANLARALLRRASELDPRH-----QPVWIAWGWMEWKEGNTTTARELYQRALSIDANTESASRCLQAWGVLEQRAGNLSAARRLFRSSLNINS--QSYVTWMTWAQLEEDQGDTERAEEIRNLYFQQRTEVVDDIIDPALDTVKRLLNFGQNNDNNRL................................................................................................................................................................................................................................... 581
17 -24.600[T] KOG4162 Predicted calmodulin-binding protein  ali follow..  14  435.....EKHSHALRVLQESMKLTPSDPLPCLQGLDYAQQAPSRSQLFVGIGHQQLAIQSNLKSERDACHKLALDALERAVQFDGNDHLAEYYLSLQYALLGQLAEALVHIRFALAL-EHAPCLHLFALLLTSSAHLQLHLEDAETALGTVQHMLAVWRDVYEAQ-QIEIWLLLADVYLRIDQPNEALNCIHEASQIYPLS-----HQIMFMRGQVHVYLEQWFDAKQCFLNAVAANPNH---TEALRALGEAHLVLGEPRLAEKMLKDAAKLD---SCPKIWFALGKVMEILGDFHASADCFATSLQLEPS............................................................................................................................................................................................................................................................... 847
18 -24.400[DO] KOG1174 Anaphase-promoting complex (APC), subunit 7  ali follow..  13  254.......................KNSVLKFEQAQMLDLYLIKGMDVYGYL-----------LAREGRLEDVENLGCRLFNISDQHAEPWVVSGCHSFYSKRYSRALYLGAKAIQLNSNS------VQALLLKGAALRNMGRVQEAIIHFREAIRLAPCRLD------CYEGLIECYLASNSIREAMVMANNVYKTLGAN-----AQTLTLLATVCLEDVTQEKAKTLLDKALTQRPDY---IKAVVKKAELLSREQKYEDGIALLRNALANQS---DCVLHRILGDFLVAVNEYQEAMDQYSIALSLDPN--DQKSLEGMQKMEKEESPTDATQEEDVDDME............................................................................................................................................................................................................................... 537
19 -24.200[U] KOG0547 Translocase of outer mitochondrial membrane complex, subunit TOM70/TOM72  ali follow..  11  315.............VANDLLTKSTDMYHSLLSANTVDDPLREN--AALALCYTGIFHFLKNNLLDAQVLLQESINLHPTPN-------SYIFLALTLADKENSQEFFKFFQKAVDLNPEYPP------TYYHRGQMYFILQDYKNAKEDFQKAQSL------NPENVYPYIQLACLLYKQGKFTESEAFFNETKLK-----FPTLPEVPTFFAEILTDRGDFDTAIKQYDIAKRLEEVKATILARQSSQDPTQLDEEKFNAAIKLLTKACELDPRS--EQAKIGLAQLKLQMEKIDEAIELFEDSAILARTMDEKLQATTFAEAAK................................................................................................................................................................................................................................................ 611
20 -24.100[O] COG5159 26S proteasome regulatory complex component  ali follow..  11  3....................................................................................LPGSKLEEARRLVNEKQYNEAEQVYLSLLDKDSSQSSAAAGATSILELGQLYVTMGAKDKLREFIPHSTEYMMQFAKSKTVKVLKTLIEKFEQVPDSLDDQIFVCEKSIEFAKREKRVFLHSLSIKLATLHYQKKQYKDSLALINDLLRELDDKPSLVDVHLLESKVYHKLRNLAKSKASLTAARTAANTQTVAELDLMSGILHCEDKDYKTAFSYFFESFESYHNLTTHNSYEKACQV-------------------------------LKYMLLSKIMLNLIDDVKNILNAKYTKETYQSRGIDAMKA-----------------------------------------------------------VAEAYNNRSLLDFNTALKQYEKELMGDE--SHFNALYDTLLESNLCKIIEPFECVE----------------SHISKIIGLDTQQVEGLDKIFYGVLDQGNG.......... 395
21 -23.900[R] KOG1125 TPR repeat-containing protein  ali follow..  12  228.NSESASELELVAPTQARLTKEHRWGSALLSAVESDTEFWDKMQAEWEEMARRNWISENQEAQNQVTISASEKGYYFHTENPFKDWPGAFEEGLKRLKEGDLPVTILFMEAAILQDPGD------AEAWQFLGITQAENENEQAAIVALQRCLEL------QPNNLKALMALAVSYTNTGHQQDACDALKNWIKQAHQNGDMIDPDLQTGLGVLFHLSGEFNRAIDAFNAALTVRPED---YSLWNRLGATLANGDRSEEAVEAYTRALEIQPGF--IRSRYNLGISCINLGAYREAVSNFLTALSLQRKSRNQQQVPHPAISGNIWAA............................................................................................................................................................................................................................................ 593
22 -23.300[B] KOG1156 N-terminal acetyltransferase  ali follow..  13  1.............................MPAVSLPPKEN-------ALFKRILRCYEHKQYRNGLKFCKQILSNPKFAEH----GETLAMKGLTLNCLGKKEEAYELVRRGLRNDLKS------HVCWHVYGLLQRSDKKYDEAIKCYRNALKWDKD-------LQILRDLSLLQIQMRDLEGYRETRYQLLQL-----RPAQRASWIGYAIAYHLLEDYEMAAKILRKTQQTSPDKVDYSELLLYQNQVLREAGLYREALEHLCTYEKQI---DKLAVEETKGELLLQLCRLEDAADVYRGLQERNPE............................................................................................................................................................................................................................................................... 256
23 -23.200[R] KOG1128 Uncharacterized conserved protein, contains TPR repeats  ali follow..  12  327............AELERGRVRQVDRSCTQSELVDPVLIKDRLLRTSYILASGQSSVLLAGILNSLGCTSEALLILEK--------LEMWDGVIDCYKQLGQMDKAETLIRRLIEQKPND------SMLHVYLGDITRNLEYFTKAIELSDD------------RNARAHRSLGHLLLMDKKFEEAYKHLRRSLEL-----QPIQLGTWFNAGYCAWKLENFKESTQCYHRCVSLQPDH---FEAWNNLSAAYIRHGQKPKAWKLLQEALKYNYEH---NVWENYMLLSVDVGEFSQAIQAYHRLLDMNKRGADDEVLELIAQTLLRREAEISMDESEDKAQNEAENRKEK-------------MIKLLARISANHQTLSPKTLRVYALLKKPSVLSSETRTEFEKYVRLLEKSLAAANGKLTWPKEEKLETAVRLAEDRLELAKFIASDTSVKEASAKVRLSLRGILTRLDKDSGSRVSGDETEKLQEIVEVA-KSLLDSVA............................................................... 786
24 -22.800[S] KOG3060 Uncharacterized conserved protein  ali follow..  53.......................................................................................ILEQVIIAALDTARFDIATKCTKQLSLEFPGSLR------VMKFKAMRYEALEQYDEADEVLDAIIAKDET-------AAPRKRKIAILKARGRRLEAIKELNEYLKKFMSD-----QEAWHELCNMYLAEGEFGKAAFCMEEVLLHNPHS---HLIHQRLAEIRYTMGNMESARTYYSQALKLNPHN--LRALYGIYLCCNHLDNSRAVSSKRKELQKLSEQLLTKQTIVPLEAAFGNLEIK........................................................................................................................................................................................................................................... 280
25 -22.800[O] KOG0548 Molecular co-chaperone STI1  ali follow..  228.....................................................................EPEVTEEKEKKERKEKAKKEKELGNAAYKKKDFETAIQHYSTAIEIDDED------ISYLTNRAAVYLEMGKYNECIEDCNKAVERYEPAIEAFQKALTEHRNPDTLKRLNDAERAKKEWEQKQYF-----DPKLGDEEREKGNDFFKEQKYPEAIKHYTEAIKRNPND---HKAYSNRAASYTKLGAMPEGLKDAEKCIELDPTF--SKGYSRKAAVQFFLKEYDNAMETYQAGLEHDPSNQELLDGVKRCVQQINKANRGDLTPEELKERQAK............................................................................................................................................................................................................................. 517
26 -22.800[R] COG0457 FOG: TPR repeat  ali follow..  12  513.HKDIVTTLNILDVLYYKMGEYKKALQFSERALAIGETIVQHPDVATSLDNLAGLYESMGNYKQALQLSERALEIYEKGPQHRDVAITLDNLAGLYESMGEYEKALIFYQRTIEIKEKVPQHSNFATSLDNLAVLYRQMGEYEKALQLSQRALEIYEKVPQHPDIATTLNNIALLYDSMGDYQKTLPLYQRALEINEKPQYLGIATTLNNLAGFYRRVGDYEKALSLSQRSLEIDEQHPDVARTLNSLALIYENIGDYEKALAFYQRSLDIREKVDVGRTLNNLARLYEIMGDHEKALTLYQRTIEIKEKALGPQHATILNNLAGLHYRIGEYKKALPLYQRA.............................................................................................................................................................................................................................. 879
27 -22.700[OT] KOG1464 COP9 signalosome, subunit CSN2  ali follow..  6............................................................DDFMCDDEEDYDLEYSEDSNSEPNVDLENQYYNSKALKEDDPKAALSSFQKVLELEGEKGEWG--FKALKQMIKINFKLTNFPEMMNRYKQLLTYIRSAVTRNYSEKSINSILDYISTSKQMDLLQEFYETTLEALKDAKNDRLFKTNTKLGKLYLEREEYGKLQKILRQLHQSCQTDDGLLEIYALEIQMYTAQKNNKKLKALYEQSLHIKSAIPHPLIMGVIGKMHLREGEFEKAHTDFFEAFKNYDESGSPRRTTCLKYLVLANMLMKSGINPFDSQEAKPYKNDPEILAMTNLV---------------------------------------------------------------------------------------------------------------------SAYQNNDITEFEKILKTNHSNIMEHIEELLRNIRTQVLIKLIKPYTRIHIPFISKELNIDVADVESLDNTIHGRIDQVNQ.......... 407
28 -22.600[S] KOG4648 Uncharacterized conserved protein, contains LRR repeats  ali follow..  115...................................................................LSQESESEEDGIHVDSQKALVLKEKGNKYFKQGKYDEAIDCYTKGMDADPYN------PVLPTNRASAYFRLKKFAVAESDCNLAVAL------NRSYTKAYSRRGAARFALQKLEEAKKDYERVLELIEAQQNKQQAISEKDRGNGFFKEGKYERAIECYTRGIAADGAN---ALLPANRAMAYLKIQKYEEAEKDCTQAILLDGSY--SKAFARRGTARTFLGKLNEAKQDFETVLLLEPGNKQAVTELSKIKKELIEKGHWDDVFLDSTQRQNVVKPIDNPPHPGSTKPLKKVIIEETGNLIQTIDVPDSTTAAAPENNPINLANVIAATGTTSKKNSSQDVLFPTSDTPRAKVLKIEEVSDTSSLQPQASLKQDVCQSYSEKMPIEIEQKPAQFATTVLPPIPANSFQESDFRQLKSSPDMLYQQIVKILHDFYIEKEKPLLIFEILQRLS-ELKRFDMAVMFMSETEKKIARALFNHID--KDSSVEELKKRY 663
29 -22.500[O] KOG0550 Molecular chaperone (DnaJ superfamily)  ali follow..  14  73.....GEFELALCDAKQSDRIKPDVPKTQSRIRQAYEGLSILNEAEVYL-----------KNKQAGLALNALDRLQRRIDSTTQPPMSWMLKAQVYIFQNDMDRAQKIAHDVLRLNPKN------VEALVLRGKVMYYSGENAKAITHFQEALKLAKTLFKQVRKLENTKNQGNDLFRQGNYQDAYEKYSEALQI-DPDNKETVAKLYMNRATVLLRLKRPEEALSDSDNALAIDSSY---LKGLKVRAKAHEALEKWEEAVRDVQSAIELDASD--ANLRQELRRLQLELKKSKRKDHYKILGVSKEAT--DIEIKKAYRKLALVYHPDKNAGNLEAEARFKE............................................................................................................................................................................................................................. 393
30 -22.300[U] KOG3081 Vesicle coat complex COPI, epsilon subunit  ali follow..  5....GAGPDHLFNLRNNFYLGAYQTAINNSEIANLSPENAVERDCLVFRSYIAL---------------SYQLVISEIDESAATPLQAVKLLAMYLSTPQNKESTISSLKEWLADSTIGNN----DTLRLIAGIIFMHEEDYNETLKHTHAGGTM-----------DLYALNVQIFIKMHRAEYAEKQLRVMQQI---DEDHTLTQLASAWLNLAVGGSKIQEAYLIFEDFSEKYPMT---CLILNGKAVCCMQMGNFDEAETLLLEALNKDAKD--PETLANLVVCSLHVG--KSSSRHLSQLKLSHPE---SSAEDNFERAVQLVA............................................................................................................................................................................................................................................. 293
31 -22.100[DO] KOG4322 Anaphase-promoting complex (APC), subunit 5  ali follow..  459.............................................................................QQNNTESFAVALCHLAELHAEQGCFAAASEVLKHLKERFPPNSQHAQLWMLCDRKAVVLQAQNQMSEAHKLLQKLLVHCQKLKNTEMVISVLLSVAELYWRSSSPTIALPMLLQALALSKEYRLQYLSETVLNLAFAQLILGIPEQALSLLHMAIEPIGAILDKGRAMFLVAKCQVKAEALEAAIENLNEAKNVDCKERIRDVVYFQARLYHTLGKTQERNRCAMLFRQLHQEL.............................................................................................................................................................................................................................................................. 744
32 -21.800[V] KOG0624 dsRNA-activated protein kinase inhibitor P58, contains TPR and DnaJ domains  ali follow..  11  7..................................................................LLILWSSLFASTFAGTAEEVAKHLELGSQFLARAQFADALTQYHAAIELDPKS------YQAIYRRATTYLAMGRGKAAIVDLERVLEL------KPDFYGARIQRGNILLKQGELEAAEADFNIVLNHDSSNNDVEQHRQLRHQIKSAYAGGDCATVEEYINHIIEIQVWD---ASLYRMRAKCLEERGELKKAIHDMRIVSKLST--DSTDTMFETSKLLYTVGDLEESLNVIRECLKLNPDHKSRKVVKSLESMKKKVENSDWMACLEEGQKTMKFDPTPSVQLNVFRITNRCQREAGHISEAIAECNEILNDDPSDADILCERAEAHILDEDYDSAIEDYQKATEDHREAKEGLEHAKRLKTQAGKRDYYKILGVKRNASKREITKAYRKLAQKWHPDNFSDEEEKKKAEKKFIDIAAAKEVLQDE---EKRRQFDQ.......................................................... 445
33 -21.500[OT] KOG1308 Hsp70-interacting protein Hip/Transient component of progesterone receptor complexes and an Hsp70-binding protein  ali follow..  1..................MDPCKVNELRFVKMCKQDPSVLHTEEMR------------------------FLREWVESMGGKVPPATQKAKSEENTKEEKPDSKKVEEDLKADEPSTEESD------LEIDKEGVI--EPDTDAPQEMGDENVEITEEMMDQ---ANDKKVAAIEVLNDGELQKAIDLFTDAIKL-----NPRLAILYAKRASVFVKLQKPNAAIQDCDRAIEINPDS---AQPYKWRGKAHRLLGHWEEAAHDLAFACKLDYDEDASAMLKEVQPRAQKIAEHWRKYERKHEEREIKERIERVKKAQEEQERAQREEEARRQSG...................................................................................................................................................................................................................................... 275
34 -21.000[S] KOG4555 TPR repeat-containing protein  ali follow..  16  27............................................................................................SLQTNNLIPAESDLKDEEPDTQAIKASRE-------LELKAIALSESGELDGALELFQQSLNLAQR-------ASVLNNRAQTLRLAKRDEEALDDLNKALELANDQQTRTKCHAHCQRGVLYRKLDNLEAARADFEAAAQLGSK---FAREQLVEINPYAALCNLRQAFDQLK........................................................................................................................................................................................................................................................................................................... 185
35 -20.700[S] COG4700 Uncharacterized protein conserved in bacteria containing a divergent form of TPR repeats  ali follow..  39.......................................................................VAYFVIVMLPETGADRHGHTLLMRLQDKLNPERHLRKLTEELAIAETNQN-------HYALANELARLGRYHEAVPHYQQALS-----GIFAHEAAMMLSLAQAQFAIQEFAACQQTLEDVMRY---NPDFQSADGHLLFARTLAAQEKYADAESEFEVLISYYPGPQ----ARIYYAEMLAKMSRLREANEQYVAVVDTAKRSRPHYRKHHREWIKTANERLKQSV........................................................................................................................................................................................................................................................................... 246
36 -20.600[S] KOG4814 Uncharacterized conserved protein  ali follow..  115...........FLIADECF----QAAVASLEQLTMEKITVESDHFRVLSYQAESAVAQGDFQRASMCVLQCKDMLMRLPQMTSSLHHLCYNFGVETQKNNKYEESSFWLSQSYDIGKMDKKSEMLAKVLRLLATNYLDWDDYDKALNAVNLANKIHERFKSSENIGKVLILHTDMLLQRKEELLAKEKIEEIFL-LTAESMNWLHNILWRQAASSFEVQNYTDALQWYYYSLRFYEMDLDFTKLQRNMACCYLNLQQLDKAKEAVAEAERHDP--RNVFTQFYIFKIAVIEGNSERALQAIITLENILTDVAERGSPTMLLSLAAQFALENGQQIVAEKALEYLAQHSEDQEQVLTAVKCLLRFLLPKIAEMPESEDKKKEMDRLLTCLNRAFVKLSQPFGEEALSLESRANEAQ---NLAVQCDKDPVMMREFFILSYKMSQFCPSDQVILIARKTCLLMAVAVDLEQGRKASTAFEQTMFLSRALEEIQTC-NDIHNFLKQTGTFSNDSCEKLLLLYEFEVRAKTIAIIAMEKPAHYPLIALKALKKA---DISQYSKCMHNL 798
37 -20.100[S] COG3898 Uncharacterized membrane-bound protein  ali follow..  10  78.VRRRDRGYQALSTG-AAGAGDGALARKKTKEAA--KLIRSDQEPLIHLLEAQASLLEGD-------HEGARQKFESMLDDPEMRLLGLRGLYLEAERLGDRNAARHYAGRAAAVAPQL------AWAAESTLEELTARGDWDGALKLVDAQKSTRQIERDANRRRAVLLTAKAQSLADSDPNAARTAALEANKL-----QPDFAPAAVAAAAALFKQNDVRKGSKILETAWRAEPHPENHAESSMTVARAALDAQDFSTARSEAEAAIRMDRREGAYLLLADI--EEAETGDQGKVRQLLSKAVRAPRD............................................................................................................................................................................................................................................................... 395
38 -18.700[S] KOG4507 Uncharacterized conserved protein, contains TPR repeats  ali follow..  10  160CTKILELPCSI-------------HAFQHLRGVQERVNLSAPLLPKEDPIFTYLSKRLGRSIDD------IGHLIHEGLQKNTSSWVLYNMASFYWRIKNEPYQVVECAMRALHFSSRHNK----DIALVNLANVLHRAHFSADAAVVVHAALDDSDF-------FTSYYTLGNIYAMLGEYNHSVLCYDHALQAAINKPNAPIWLILNEAGLYWRAVGNSTFAIACLQRALNLAPLQYQ-DVPLVNLANLLIHYGLHLDATKLLLQALAINSSE--PLTFLSLGNAYLALKNISGALEAFRQALKLTTKCPECENSLKLIRCMQFYPFLYNITSSVCSGNCHEKTLDNSRDKQKYFDNSQSLDAAEEEPSERGTEEDPVFSVENSGRDSDALRLESTVVEESNGSDEMENSDETKMSEEILALVDEFQQAWPLEGFGGALEMKGRRLDLQGIRVLKKGPQDGVARSSCYGDCRSEDDEATEWITFQVKRVKKPKGDHKKTPGKKVETGQIENGHRYQANLEITGPKVAS----GPQGLLDWKTR---KV............... 955
39 -18.600[O] KOG4642 Chaperone-dependent E3 ubiquitin protein ligase (contains TPR repeats)  ali follow..  14  16...........................................................................GGGSPEKSPSAQELKEQGNRLFVGRKYPEAAACYGRAITRNPLV------AVYYTNRALCYLKMQQHEQALADCRRALELDGQ-------VKAHFFLGQCQLEMESYDEAIANLQRAYSLAKEQRL............................................................................................................................................................................................................................................................................................................................................................................ 129
40 -18.400[H] COG3071 Uncharacterized enzyme of heme biosynthesis  ali follow..  11  78.GRKRTRARNQMKAA-KLAEGDFLQVEKLLTRNADHA----EQPMVNYLLAAEAAQQRGDEFRTNQYLERAAE------VADGDQLPVNITRVRIQLAQGHIHAARHGVDRLLDQAPRH------PEVLRLAEQAYLRSGAYRSLLDILPAMSKTQIHTPEEVAEQQAYIGIMNQCMADEGSEGLKRWWKDQSRKVRNEIP-----LQVALAEHLIECDDHDVAQKIILDSLKHIKQHGATPLLNSTLGQLMLKHGEWEKASEAFKAALAQRP---DGYDYAWLADALDKLHRPEDAAQARREGLLLT................................................................................................................................................................................................................................................................. 391
41 -18.200[K] COG2909 ATP-dependent transcriptional regulator  ali follow..  367.AGDVGMLRDILLQHSLFHHSELALLEQCLTALP-YPLLVQNPELALLQAWLAQSQHRYSEVNTLLEQAELAMQERKIPVDEILRAEFGALRAQVAINAGKPDEAEKLATDALKYLPM-AHYYSRIVATSVTGEVHHCKGELARALPMMQQTEQMARRHEAYHYALWALLQQSEILIAQGFLQAAYETQEKAFELIREQQLPMHEFLLRIRSQVLWSWSRLDEAEEAARKGVEILANPQQQLQCLAMLAKCSLARGDLDNANVYIQRCEALQHGSQITNADKPRVIHWQMTGDKVAAASWLRQTEKPGMADNHFLQGQWRNIARVQIILGRFDEAEVVLDELNENARRLRLTSDLNRNLLLSNTLY-----WQTERKGEAQKALIESLTLANRTGFISHFVIEGEAMAQQLRQLIQLNALPELEQHRAQRILKDINQHHRHKFAHFDEIFVDKLLTHPQVPELIRTS---------------------------------------PLTQREWQVLGLIYSGYSNDQIANELDVAATTIKTHIRNLYQKLGVAHRQEMMGYV... 903
42 -17.700[O] KOG1463 26S proteasome regulatory complex, subunit RPN6/PSMD11  ali follow..  11  2....AAAAVVEFQRAQSLLSTDREASIDILHSIVKRDIQENDEEAEQSILELGSLLAKTGQAAELGGLLKYVRPFLNSISKAKAARLVRSLLDLFLDMEAATGQEVELCLESIEWAKSEKRTFLRQALEARLVSLYFDTKRYQEALHLGSQLLRELKKMDDKALLVEVQLLESKTYHALSNLPKARAALTSARTTANAPPKLQATLDMQSGIIHAAEEKDWKTAYSYFYEAFEGYDSIDSPSLKYMLLCKIM--LNTPEDVQALVSGKLALRYAGRQTEALKCVAQASKNRSDFEKALTDYRAELRDDAKLYDNLLEQNLIRVIEPFSRVQIEHISSLIKLSKADVE.......................................................................................................................................................................................................................... 362
43 -17.200[S] COG1655 Uncharacterized protein conserved in bacteria  ali follow..  10  79.................................................................................................................KIKSYQKELVEKNISLKWHSKKYPDIYDINIAIERFKLSLLNYVSIEAHSSKAMNCLKIAWMYRIQQNEDMEKVFLKNALEG-------------------------FDDAYY------SFPIYGMNKFSLMYLIGELHRRLGDEDKALLWFGNVITNSL--APQKLKEMARNQKDLIRENEKKLSQTQDNDSNDDDNSEATTPKKKGLFSKLFNN............................................................................................................................................................................................................................................ 264
44 -16.900[S] COG1747 Uncharacterized N-terminal domain of the transcription elongation factor GreA  ali follow..  26...RQSILDVLKGICDEHLAHSKNSALYISGIISLSKQLLDDS----CLVTLLTIFGDNHKNQIVEHLCTRVLEYGES-------KLALRALGECYKTSGN-EQLYDVWERLVRIDYEEAE------ITRVLADKYEQEGNKEKATEFYKKALYRFIARRQNAAIKEVWTKLVAL-----IPDDVEFFYREQKKISEKLGEGRGSVLMQDVYVYYKENEDWTTCINILKHILEHDEKDVW---ARKEIIENFRCKYRGHSQL----------------EEYLKISNISQSWRNVFEAINDFEKHISFDEGSFVFHRTWGVGRIA------KVCNDELLIDFAKRRAHTMLLKMAISALQTLGKEHIWVLKSVLKRQDLAAKIRQDPEWALKVIITSFDNNCNLKKVKQELTKARKILKESTGFAANPSNIDFYTVRSCPVSLEEKLAVEFKA------QKNFFARIDILNTFMDKADTDSDAFREMFDYFNTFLRAVVTRVSTVLPHLNAC-----GFADLYAHIADPRLVYEIKDKGLKWEFVNSVKNFVSNWSDEYVKLF... 558
45 -16.600[O] COG3914 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family  ali follow..  10  2...........................................................................................PQDVMTANHVSPSNDAAAPSALDLARNQRLS---LMDLLSVSEALNAAGQQAAAAELYKTWVAFNDNNPT---IHLAYFNYAVMLNQLGDRAGAVQAFRACLKA-----NPEFAPGHINLGRALEDAGLIGHAVEQWSHYAEVTKNVDAEHMTLQNMGRVLEGAGKLEEAETALLQAFELR---ELPEAGQHWASLRQRQCKWPVLAPSNHISPRKMLDAMSSLTLSCYADDPMFQLAKAYRLSKTLIGARPDLSRFPRRS----------------KQKSGTGQRLRVGYLSSDLRDHAVGFALCEVLELHDKDSLEVFAYYCGNVRGTDSTQERIKAAVHCWRDIHGVDDATAASQIIADEIDILDVNGYTKDARAKIFAYRPAPVIVSFCGYPGSMEIYYSEKVLRIACDQPLLPEDAFVYASF-MQKITENCFARILSETPGSLDDVNQRLRDRLVFAPKAQNPQHIARI 509
46 -16.600[MOT] KOG1550 Extracellular protein SEL-1 and related proteins  ali follow..  12  553..................LRRDHTKALHWFLKAVDKGEPRSMELLGEIYARGAGVERNYTK---------ALEWLTLAAK--EGLYSAFNGIGYLYVKKKNYTKAREYFEKAVDNED--------PSGHYNLGVLYLKNRDVRQATKYFFVAAN--------AGQPKAFYQLAKMFHTKKNLEMATSFYKKALILYSRMAEMGYEVAQSNAAWILDKKERHERAHSLWWRASE-----QGNEHAALLIGDAYYYERDFVRAAEAYMHAKSQSN----AQAMFNLGYMHEHPFDLHLAKRYYDESLQSDAA............................................................................................................................................................................................................................................................... 870
47 -16.500[O] COG4235 Cytochrome c biogenesis factor  ali follow..  26.....................................................................................VVALIVAGVSYYQTGNYQ-QVKIWQQATAQAPALLDR------ALDPKADPLNEEEMSRLALGMRTQLQ------KNPGDIEGWIMLGRVGMALGNASIATDAYATAYRLDPKN-----SDAALGYAEALTRSSDNRLGGELLRQLVRTDHSN---IRVLSMYAFNAFEQQRFGEAVAAWEMMLKLANDTRRAVIERSIAQAMQHLSPQES............................................................................................................................................................................................................................................................................. 220
48 -15.500[R] COG4105 DNA uptake lipoprotein  ali follow..  11  42............................................................................SKYVDQTEPADVLYNQGLANLNAGRLDEASKKFDA---VDRQHPYSEWARKSMVMGAFADYRKGSYDEAISSAKRYLALY----STDDAPYAQYIIGLSYYRQKEARQTLQTMQDLVTRWPTSEYVDDAKEK-QIGRYYLERREYIAAVKRFRTVVENYSNTRHVEEALARLTESYYAMGLTSEAQTAAAVLGTNPDSPWYKDSYKLLQSNGLSPRENAGSW........................................................................................................................................................................................................................................................................... 278
49 -15.500[D] KOG1915 Cell cycle control protein (crooked neck)  ali follow..  274...............................................................EDAIIGKRRCQYEDEVRKNPLNYDSWFDFVRLEETVGNKDRIREIYERAVANVPPPEAQRYIYLWINYAFFAEMVTEDVESTRDVYRACLKLI---HSKFSFAKIWLLAAQHEIRQLNLTGARQILGNAIGKAPKDK------IFKKYIEIELQLRNIDRCRKLYERYLEWSPGN---CYAWRKYAEFEMSLAETERTRAIFELAISQPALDMPELLWKTYIDFEISEGELERTRALYERLLDRTKHCKVWVDFAKFEASAAEHKEDEEEED-------------------------------AIERKKDGIKRAREIFDRANTYNKDSTPELKEERAMLLEDWLNMETGFGKLGDVRVVQSKLPKKVKKRKLSSREDGCTEYEEYTDYLFPEESETTSLKILEAAHKWKKQKVKAGEC................................................................................... 656
50 -14.800[A] KOG2047 mRNA splicing factor  ali follow..  10  393................KIFEGNAAKQILTYEAVRTVDPMKAVGKPHTLWVAFAKLYENHKDLVNTRVIFDKA--VQVNYKTVDHLASVWCEWAEMELRHKNFKGALELMRRATAVPTVEVRRRVAARLWSFYVDLEESLGTLESTRAVYEKILDLRIATPQ------IIMNYAFLLEENKYFEDAFKVYERGVKIFKYPHVKDIWVTYLTKFVKRYGKTKLERARELFEHAVSMAPSDA-VRTLYLQYAKLEEDYGLAKRAMKVYEEATKKVPEGQKLEMYEIYISRAAEIFGVPRTREIYEQFAELERSLGEIDRARALYKYSSQFADPRSDPEFWNKWHEFEVQH---------------------TYREMLRIKRSVSASYSQTHFILPENMMQKDKLLDVEDAKGELKRAGLPEDEMAALERQLLSTTTPTEPAKDGGRRVGFVSAGVISQSGENEGKPVTGNGEDIELPDESDDESDGDDHVEISQKEVPAVFGGLARKRDEDGEEAGE-----------------AAQKLGALERIKRQKLNQ................ 917
51 -14.600[R] KOG4234 TPR repeat-containing protein  ali follow..  10  95...........................................................................GSNKEKALAEANEAKAEGNKLFVNGLYEEALSKYAFALELVQELPEIELRSICYLNRGVCFLKLGKCEETIKECTKALEL------NPTYNKALVRRAEAHEKLEHFEDAVTDLKKILELDPSNDQ-----ARKGIRRLEPLAAEKREKMK................................................................................................................................................................................................................................................................................................................................................... 235
52 -14.500[R] KOG3807 Predicted membrane protein ST7 (tumor suppressor in humans)  ali follow..  206.................................................................................................................................DTVMQKAWRERNPPARIKAAYQALELNNDCAT------AYVLLAE--EEATTIVDAERLFKQALKAGE-----------TIYRQSQQCQHQSPQHEAQLRRDTN-------LVYIKRRLAMCARKLGRIREAVKIMRDLMKEFPPLTMLNIHENLLESLLELQAYPDVQAVLAKYDDILPKSAAICYTAALLKTRTVSEKFSPETASRRGLSTAEINAVEAIHRAVEFNPHVPKYLLEMKSLILPPEHILKRGDSEAIAYAFFHLQHWKRIEGALNLLQCTWEGTFHHVSVYPKKELPLFIHFTAGFCSSTAMIAILTHQFPEIM-----------------------------GIFAKAVLGLW--ASSGFEENTQDLKSED--------LGLSS........................................ 543
53 -14.400[A] KOG0495 HAT repeat protein  ali follow..  10  556.EKNHGTRESLEALLQRAVAHCPKSEILWLMGAKSKWMAGDVPAARGILSLAEDIWLAAVKLESENSEYERARRLLAKARGSAPTPRVMMKSARLEWALEKFDEALRLLEEAVEVFPDFPK------LWMMKGQIEEQQRRTDDAAATYTLGLKKCPTSIP------LWILSANLEERKGVLTKARSILERGRLRNPKV-----AVLWLEAIRVELRAGLKEIASTMMARALQECPNAGELPHVLLAVSKLFWSEHKFSKCRDWFNRTVKID---DLGDAWAYFYKFELLHGTEAQQQEVLDRCISAEPT............................................................................................................................................................................................................................................................... 879
54 -14.300[O] KOG0551 Hsp90 co-chaperone CNS1 (contains TPR repeats)  ali follow..  15  70............................................................................DEERSPEEQAKTYKDEGNDYFKEKDYKKAVISYTEGLKK--KCADPDLNAVLYTNRAAAQYYLGNFRSALNDVTAARKL------KPCHLKAIIRGALCHLELKHFAEAVNWCDEGLQIDAKEKK............................................................................................................................................................................................................................................................................................................................................................................ 186
55 -14.200[O] KOG0543 FKBP-type peptidyl-prolyl cis-trans isomerase  ali follow..  10  232.............................................................................................................................................................ISEEKLEQNTVVKEQGSVYFKEGKYKQALLQSQKAQAP--------PLASHLDLAMCQLKLQAFSAAIESCNKALELDSNN---EKGPFRRGEAHLAVNDFELAWADFQKVLQLY---NNKAARAQLAVCQQRIHRQLARKKFYAKMFERLAEEENKAKAEACSGDHPTDTEMKAEWKSNTAGSQSQVET.......................................................................................................................................................................................................................... 408
56 -13.800[R] COG0790 FOG: TPR repeat, SEL1 subfamily  ali follow..  11  36.....................................................................LTQKDLDALPVEKR--ASVLDELGFIHEYPMNRERALQYYKQACELGGNYGCY--------NVKYAYQYAKDSAQANKYAKKMAAFISILIHQDGDPQMDYQMGRLTLNYQARPASLKWFRAAAE-------KGVVEAQSLLGGIYSGKPDIQEAQKWYGQAAK-----QGDSDAQIALGKIYYSRTDYAKALALFTQVENDGT---NSRSTMPLSWMYYNAPDCDKAWSYYKKASRYVGK----KVEEKIFLSKCAADIQSRKNNADALPK................................................................................................................................................................................................................................ 376
57 -13.400[O] KOG1498 26S proteasome regulatory complex, subunit RPN5/PSMD12  ali follow..  15............................................................................KMEVDYSATVDQRLPECAKLAKEGRLQEVIETLLSLEKQTRTASDMVSTSRILVAVVKMCYEAKEWDLLNENIMLLSK--RRSQLKQAVAKMVQQCCTYVEEITDLPIKLRLIDTLRMVTEGK-EIERARLTKTLATIKEQNGDVKEAASILQELTYGSMEKKERVEFILEQMRLCLAVKDYIRTQIISKKINTKNTEKLKLKYYNLMIQLDQHEGSYLSICKHYRAIYDTPCIQAESEKWQQA-----------------------------------LKSVVLYVILAPFDNEQSDLVHRISGDKKLEEIPKYKDLLKLFTTMELMRWSTLVEDYGMELRKGSLESPATDVFGSTEEGE-------------------------------------------------------------KRWKDLKNRVVEHNIRIMAKYYTRITMKRMAQLLDLSVDESEAVNKTIFAKVDFQRPKDPNNLLNDW 428
58 -12.700[T] KOG1309 Suppressor of G2 allele of skp1  ali follow..  1..................................................................................................................................................................MPVEKDLKTAYKALYDEKEPLKALHLYDEILKGSPTNLTIFKAACLEKLYSDWHSDATMENAKELLDKALMTAEGRSKIGLVNFRYFVHFFNIKDYELAQSYFKKAKNLGYVDDTLPLW--EDRLETKLNKKNKKQKDSTNKHTIKPVESIENRGDNNSSHSPISPLKIETAPQESPKFKIDWYQSSTS-------VTISLFTVNLPESKEQVNIYISPNDRRTLSISYKSGSEFQYNAKLSHEVDPKAVSLKIFPKKLEITLSKIDSTQWKKLEEDILTESSRLSDEGKNSDSATRLLSAETASKERLSYPSSSKKKIDWSKLDIDEEADEEA--GSADSFFQKLADPDTK--AMMK-SFIESN-GTALSTDWEDVSKGTVKTSPPEGMEPKH......... 394
59 -12.700[R] COG5091 Suppressor of G2 allele of skp1 and related proteins  ali follow..  1..................................................................................................................................................................MPVEKDLKTAYKALYDEKEPLKALHLYDEILKGSPTNLTIFKAACLEKLYSDWHSDATMENAKELLDKALMTAEGRSKIGLVNFRYFVHFFNIKDYELAQSYFKKAKNLGYVDDTLPLW--EDRLETKLNKKNKKQKDSTNKHTIKPVESIENRGDNNSSHSPISPLKIETAPQESPKFKIDWYQSSTS-------VTISLFTVNLPESKEQVNIYISPNDRRTLSISYKSGSEFQYNAKLSHEVDPKAVSLKIFPKKLEITLSKIDSTQWKKLEEDILTESSRLSDEGKNSDSATRLLSAETASKERLSYPSSSKKKIDWSKLDIDEEADEEA--GSADSFFQKLADPDTK--AMMK-SFIESN-GTALSTDWEDVSKGTVKTSPPEGMEPKH......... 394
60 -12.600[R] COG4976 Predicted methyltransferase (contains TPR repeat)  ali follow..  10  2..........................................................................TFNQLSSGDLIADRRADYAKMLAEAGDAPGAAELMAQALELAPDW------AAGWFRLADYEEKSGRIEAAVDALRNTLRLNPE-------IFGASLKLALLGATETPEQPPSVYVERLDYAERFDHALVEKLTGLFGERIRDRADFLEGFDLSANMLAKAEAKGVYDR---------LAQADLSLAPEDSGVFGALEDLVSAADVLMYLGNLEGVFVIADRLLA--ADGFVLRPSLRYAHPEASIASLCKESGLSMIATERTIIRRDA.............................................................................................................................................................................................................................. 297
61 -12.000[S] COG3014 Uncharacterized protein conserved in bacteria  ali follow..  10  19CIGYRMDLEHF---NTLYYEESPKKAYEYSK---------------------------------------------QFTKKKKNALLWDLQNGLSALYARDYKTSLGVLDQAEQRFDKTQSAYVGATMINDNVRAYG--NIYEGVLINYYKAID---------------------YMLLNDSAKARVQFNRANERQRRAKEEEVQKAIKEIDSSKKHNINMERSRAEVSEILNNTYSNLDKYEAYQGLGLFYALNGDKNKGLGYLNEAYGIS..................................................................................................................................................................................................................................................................................................... 238
62 -11.100[S] COG1356 Uncharacterized protein conserved in archaea  ali follow..  18  5...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LTEQQIKVLVLRAKGLKQSEIARILKTTRANVSILEKRALEKIEKARNT......... 53
63 -11.100[R] COG4455 Protein of avirulence locus involved in temperature-dependent protein secretion  ali follow..  1..................................................................................MKKTDTLPATLSALIQEYSIAEGIQMAEQQVRENPAKAL------CRHSLFQLLCVAGDWSRALHQLQLCARMEANYTQEARLYREL-------VRCEMFRHTVFQGEQRPGFLLPQ-----PVWVESLLAALACHDDTGEVDKHRNTALEAITDTGGQWN-----GGAFDWASDSDSRLGPVLELVTGGVYI-----FSQIRSLESPQPTRLTDLLWKPVNITLVNG------DTHGAWLFTRYSGSESASDALRLCRETA............................................................................................................................................................................................................................. 231
64 -11.000[OT] KOG1497 COP9 signalosome, subunit CSN4  ali follow..  11  2.............................................................................AANYGISTAALRSQLMGLINFTGTHKDQADKYRQLLKTVLTNTGQELIDGLRLFVEAIVNEHVSLVISRQILNDVGSELSKLPDDLSKMLSHFTLEKVNPRVISFEEQ------------------VAGIRFHLANIYERNQQWRDAATVLVETGQKQYSVECKLGTYLKIARLYLEDNDSVQAELFINRASETNSEELQVLYKVCYARVLDYRRKFIEAAQRYNELSYRKIVDQGERMT-------------------------------------ALKKALICTVLASAGQQRSRMLATLFKDERCQHLPAYGILEKMYLERIIRRSELQEFEALLQDHQ-----------------------------------------------------------------------KAATSDGSSILDR---AVFEHNLLSASKLYNNITFEELGALLDIPAVKAEKIASQMEGRMNIDQISAIVHF.... 368
65 -11.000[S] COG1729 Uncharacterized protein conserved in bacteria  ali follow..  246.....................................................................................PEELYRNSYQFILSGDYGTAEQGFRD---HISRFPRDAKAADAHYWLGESLLGQQKYRDAAEVFLAASK---DYPKAKKAPDMLLKLGVSLVGLKQHDVACATFSEVGKRYPDISSALKERV...................................................................................................................................................................................................................................................................................................................................................................... 361
66 -11.000[O] COG5071 26S proteasome regulatory complex component  ali follow..  10  9..........................................................................YSEKFAELQKSLNNL--------NTIDIDANLEKLLIFEKQVRQASDTSTNTKVLIYIADLLFRAGDFQGLNEQLVSLFK--KHGQLKQSMTSLVQHVMTYLPGIDDLKTKINLIETLRTITDGK-EVERARLTQLLSQIKEEQGDIKSAQEILCNETYGSFDLKEKVAFILDQVRLFLLRSDYYMASTYTKKI-KEDVQSLKLKYYEQKIRIGLHDDAYLDVCKYYRAVYDTAVVQEDPEKWKEILEN--------------------------------VVCFALLTPYDNEQADLLHRINADHKLNSLPLLQQLVKCFIVNELMRWPKIAEIYGSALRS-------------------------------------------------------------------NPVFAENDEKGEKRWSELRK---RVIEHNIRVVANYYSRIHCSRLGVLLDMSPSETEQAKHHFYAKIDFKKSQNVQEQLNEW 410
67 -10.700[S] COG2976 Uncharacterized protein conserved in bacteria  ali follow..  14  44...............................................................................................SHQVDXARSASLAYQNAVTAVSEGKPDS--------------------------IPAAEKFAAENKNTYGALASLELAQQFVDKNELEKAAAQLQQGLA--DTSDENLKAVINLRLARVQVQLKQADAALKTLDTI----KGEGWAAIVADLRGEALLSKGDKQGARSAWEAGVKSDVTPALSEMMQKINNL...................................................................................................................................................................................................................................................................................... 204
68 -10.700[K] COG5290 IkappaB kinase complex, IKAP component  ali follow..  11  868.SNPEYKKKYLQTIITAYASQNPSAALKLISELENSEEKDSCVTYLCFLQDVNVVYKSALSLYDVSLALLVAQKSQMDPREYLPFLQELQDNEPLRRKLGNYEKALEHLSEIDKDGNVSEE----------VIDYVESHDLYKHGLALYRKQNVIYNIYAKHLSSNQMYTDAAVAYEMLGKLKEAMGAYREAMSIAVQKFPEEVESVAEELISSLTFEHRYVDAADIQLEYLDNVKEA-----------ALYCKAYRYDIASLVAIKAKKDEEEVVDPGLGEGFGIIAELLADCKGQISQLRRLRELRA-----KKEENPYAFYGQETEQADDVSVAPSETSTQESFFTRYTGKTGGTAKTGASRRTAKNKRREERKRARGKKGTIYEEEYLVQSVGRLIERLNQTKPDAVRVVEGLREQAHQIQKNFVEVLDLLKANVKEI........................................................................................................................... 1310
69 -10.600[DO] COG5155 Separase, a protease involved in sister chromatid separation  ali follow..  789...EINSILNFFFCFLHTVEPS--AFLEIFYELNCLLHLQFSKYLVIIGTLLSDKYMTLGFSGKAHLFYTKCYSYLRQCKSSPFINFWNVSYGKYLILTGNTDKGILQLKKYSLSSEEDFNSNLLLYERIQLSDALFQLGYTTVSLGFIMQNLKVIKGLFSKSSSAHSNVCAARIYEHMGQAREAEFFYRQACSISEKMPFSCSATFQLRLCSLLTRAGKLEKGEKILFDLTEAMKSTDHKLLWNYGAAEVCATKSELDGAICHYSECVKLLEQNTAANLLRLISMFELKRGNLEIAKALMTDSTKCSIASFFNIVSANILKSKLIVCEADSTLFGDPVLRTLPDSVISLPGISHKFQKNQSKTKALGENTGFRKGSKRLDYLRERLKINLQNVRLSCEIIFSNAYERSSVCVCREVNELISYSTIMQSALTTIGETTDVDSSSASFFLEIPKALGFHRRREAQKFRNQHKELHFSSLEQSIWNVVSITINNSGEDFISKIRKGHSPL---------IFRLPLQRTELFRIISKSNQMAQKERRHLDQCLQ----ENIEIWLGGF 1480
70 -10.500[O] KOG3696 Aspartyl beta-hydroxylase  ali follow..  257..YQVYEEQAVYEPLENEGIEITEVTAPPEDNVEDSQVIVEEVSIFPVEEQQEVPPETNRKTDDPEQKAKVKKKKPKLLNKFDKTIKAELDAAEKLRKRGKIEEAVNAFKELVRKYPQSPRAYGKAQCEDDLAEKRRSNEVLRGAIETYQEVASLPDVPADL--LKLSLKRRSDRQQFLGHMRGSLLTLQRLVQLFPND-----TSLKNDLGVGYLLIGDNDNAKKVYEEVLSVTPND---GFAKVHYGFILKAQNKIAESIPYLKEGIESGD.................................................................................................................................................................................................................................................................................................... 519
71 -10.300[T] COG4566 Response regulator  ali follow..  12  154..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................KRNVERLKTLTRREREVL-VVTRGRLNKQIAFDLGISEVTVKLHRANVMRKMEVRSIGELIRVWET. 220
72 -10.100[M] KOG3364 Membrane protein involved in organellar division  ali follow..  13....................................................................................................................................AYEPLYPQQLEILRQQVVSEGGPTATIQSRFNYAWGLIKSTD----VNDERLGVKILTDIYK----EAESRRRECLYYLTIGCYKLGEYSMAKRYVDTLFEHERNNKQVGALKSMVEDKIQKETLKGVV................................................................................................................................................................................................................................................................................................................ 133
73 -9.850[K] COG2771 DNA-binding HTH domain-containing proteins  ali follow..  139.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................DQQNISSFEREEIRLRLRCMIELLTQKLTDL-VCLSHREREILQWTADGKSSGEIAIILSISESTVNFHHKNIQKKFDAPNKTL........ 230
74 -9.830[U] KOG2114 Vacuolar assembly/sorting protein PEP5/VPS11  ali follow..  11  342..........................................................................................................NLYTVAINLVQSQHDAAATANVMRKYGDHLYGKQDFDEAMLQYINTIGYLEP-----------SFVIQKFLDAQRIYNLTNYLEKLHEKGLASKDHTT------LLNCYTKLKDVEKLNTFIRKEDGIGELKFDVETAI----RVCRAANYHEHAMYVAKKAGKHEWY---------LKILLEDLGNYDEALQYVSSIEQYGKILIEHKPKETIDILMRLCTEQGIPNGVFLSMLPSPVDFITVFVQHPHSLMHFLERYAEIVQDSPAQAEINNTLSENGLDKDLIDHSVAAAVSKADPEKKTNADSKDAMEKDCTERQQKGLELLKMAWPSDLELYEKMKFYKEVIACYMQNHDHEGLIACCKRLGDSSKGGDPSWADLLKYFGEIGEDCTKEVKEVLTYIERDDI---------LPPIIVLQTLAKNPCTLSVIKDYIARKLE-QESKIIEE..... 808
75 -9.570[TDBLU] COG5032 Phosphatidylinositol kinase and protein kinases of the PI-3 kinase family  ali follow..  10 1394CGF----HARALFYWEQHIRNATAPYYRVLQEIYAGIDDPDEIEAVSLNFHDYSFDQQLLLHENSGTWDSALSCYEIIIQKDPENKKAKIGLLNSMLQSGHYESLVLSLIEASKCLSKSNLESFEAKLGSIFYQYLRKDSELTERLQPLYVDAATAIANTGAHSAYDCYDILSKLH--------AINDFSRIAETDGIVSDNLDIVLRRRLSQVAPYGKFKHQILSTHLVGYEKFENTKKTAEIYLEIARISRKNGQFQRAFNAILKAMDLDKPLATIE-----AQWWWHQGQHRKAISELNF--SLNNNMFDLVDEHEERPKNRKETLGNPLKGKVFLKLTKWLGKAGQLGLKDLETYYHKAVEIYSECENTHYYLGHHRVLMYEEEQKLPVNEQSERFLSGELVTRIINEFGRSLYYGTNHIYESMPKLLTLWLDFGAEELRLSKDDGEKYFREHIISSRKKSLELMNSNVCRLSMKIPQYFFL-----VALSQMISRVCHPNNKVYKILEHIIANVVASYPGETLWQLMATIKSTSQKRSLRGKSILN-SSKVDIKALSQSA 1979

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Rodrigues AP, Grant BJ, Godzik A, Friedberg I. The 2006 automated function prediction meeting. BMC Bioinformatics. 2007 May 22;8 Suppl 4:S1-4.