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Query: [H] COG0007 Uroporphyrinogen-III methylase, from COG0516

Results of FFAS03 search in PDB0516
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MSKADEAAACVIAKSKVALPVMEPGHVWLVGAGPGDPGLLTLHAVNALQQADVIVYDALVDDSCLSLKNATATLEYAGKRGGKPSPRQRDISLRLVELARQGKKVLRLKGGDPFVFGRGAEEALTLVEYHVPFRIVPGVTAGVGGLAYAGIAATHRDINQAVTFLTGHDATGAMPDGVDWAGIARSSPVIVMYMAMKHIGLIAGRLIEAGRSPDEPVAFVCNASLPDQTVLETTLGRAAIEVEAAGLQPPAIVVVGEVVRLRAGLDWIGAMAGKSLVSDPLGKRTQQGVQSALast
1 -112.0001s4d_A mol:protein length:280 Uroporphyrin-III C-methyltransferase  ali model follow..  73  8.................GLPALEKGSVWLVGAGPGDPGLLTLHAANALRQADVIVHDALVNEDCLKLARPGAVLEFAGKRGGKPSPKQRDISLRLVELARAGNRVLRLKGGDPFVFGRGGEEALTLVEHQVPFRIVPGITAGIGGLAYAGIPVTHREVNHAVTFLTGHDSSGLVPDRINWQGIASGSPVIVMYMAMKHIGAITANLIAGGRSPDEPVAFVCNAATPQQAVLETTLARAEADVAAAGLEPPAIVVVGEVVRLRAALDWIGAPFANRILRNPA........... 280
2 -108.0002ybo_A mol:protein length:294 METHYLTRANSFERASE  ali model follow..  40  2.MADIGSMNTTVIPPSLLDVDFPAGSVALVGAGPGDPGLLTLRAWALLQQAEVVVYDRLVARELIALLPESCQRIYVGKRCGHHSLPQEEINELLVRLARQQRRVVRLKGGDPFIFGRGAEELERLLEAGVDCQVVPGVTAASGCSTYAGIPLTHRDLAQSCTFVTGHLQNDG-RLDLDWAGLARGKQTLVFYMGLGNLAEIAARLVEHGLASDTPAALVSQGTQAGQQVTRGALAELPALARRYQLKPPTLIVVGQVVALFAERAMAHSYLGAGSPVSREAVACAL..... 287
3 -106.0002ybq_A mol:protein length:292 METHYLTRANSFERASE  ali model follow..  40  3....LGSMNTTVIPPSLLDVDFPAGSVALVGAGPGDPGLLTLRAWALLQQAEVVVYDRLVARELIALLPESCQRIYVGKRCGHHSLPQEEINELLVRLARQQRRVVRLKGGDPFIFGRGAEELERLLEAGVDCQVVPGVTAASGCSTYAGIPLTHRDLAQSCTFVTGHLQNDG-RLDLDWAGLARGKQTLVFYMGLGNLAEIAARLVEHGLASDTPAALVSQGTQAGQQVTRGALAELPALARRYQLKPPTLIVVGQVVALFAERAMAHPYLGAGSPVSREAVACAL..... 285
4 -98.4001ve2_A mol:protein length:235 Uroporphyrin-III C-methyltransferase  ali model follow..  40  2.......................RGKVYLVGAGFGGPEHLTLKALRVLEVAEVVLHDRLVHPGVLALAK--GELVPVGKEGYGGKTPQEAITARLIALAREGRVVARLKGGDPMVFGRGGEEALALRRAGIPFEVVPGVTSAVGALSALGLPLTHRGLARSFAVATGH----------DPALPLPRADTLVLLMPLHTLGGLKERLLER-FPPETPLALLARVGWPGEAVRLGRVEDLPGLGE--GLPSPALLVVGKVVGLYGELLPKDH...................... 233
5 -88.3001v9a_A mol:protein length:239 Uroporphyrin-III C-methyltransferase  ali model follow..  41  1........................GRVYLVGAGPGDPELLTLKAYRLLKEAPVVLYDRLVDERVLALA--PGEKVYVGKEEG-ESEKQEEIHRLLLRHARAHPFVVRLKGGDPMVFGRGGEEVLFLLRHGVPVEVVPGVTSLL----ASGLPLTHRGLAHGFAAVSGVLEGGG---YPDLRPFARV-PTLVVLMGVGRRVWIAKELLRLGRDPREPTLFVERASTPKERRVHARLEEVAEGK--VEVRPPALWILGEVVRVFAEKEPVDALGG................... 239
6 -79.5001pjq_A mol:protein length:457 Siroheme synthase  ali model follow..  40  191SLANADEKAVNATTERLSEPLDHRGEVVLVGAGPGDAGLLTLKGLQQIQQADIVVYDRLVSDDIMNLVRRDADRVFVGKRAGYHCVPQEEINQILLREAQKGKRVVRLKGGDPFIFGRGGEELETLCHAGIPFSVVPGITAASGCSAYSGIPLTHRDYAQSVRLVTGHLKTG---GELDWENLAAEKQTLVFYMGLNQAATIQEKLIAFGMQADMPVALVENGTSVKQRVVHGVLTQLGELA--QQVESPALIIVGRVVALRDKLNWFSN...................... 456
7 -59.7001vhv_A mol:protein length:268 diphthine synthase  ali model follow..  15  5......................HMSLLTFVGLGLWDVKDISVKGLEAVREADEVYVEYYTSKLLSSI---EEMEEFFGKRVVELERSDLEENSFRLIERAKSKSVVLLVPGDPMVATTHSAIKLEAERKGVKTRIIHGASISTAVCGLTGLHNYRFGKSATVSWHRSQTPVNVI-----KANRSIDAHTLLFLEPMTIGHAVENLIAEDAQMKDLYAVGIARAGSGEEVVKCDRLENLKK--IDFGKPLHVMVVLAKTLHFMEFLREFAPAELERLVAEGGS.......... 262
8 -58.8003i4t_A mol:protein length:292 diphthine synthase  ali model follow..  10  2...........AMGTLEAQTQGPGSMLYIIGLGLYDEKDITVRGLEAVKSCDLVFLEHYTAILQCDVAKLEE---FYGKKVIIGDRDLVETEADQILEPAKTKNVALLVVGDVYGATTHSDIFVRCQKMGIEVKVIHNASIMNAI-GCSGLQLYRFGQTVSVCFWSEHVKERSEESIIKGRDIFEPPRYMTINQCIEQLLEVEKEQHLGVYDEDTMVVGMARVACADQKIVYGKMKDLLH--YDFGAPMHCLLIPAPQVDDLDQLEYFK....................... 282
9 -56.4001vce_A mol:protein length:265 diphthine synthase  ali model follow..  13  2.........................VLYFIGLGLYDERDITVKGLEIAKKCDYVFAEFYTSL-MAGTTLGRIQKLIGKEIRVLSREDVELNFENIVLPLAKENDVAFLTPGDPLVATTHAELRIRAKRAGVESYVIHAPSI-YSAVGITGLHIYKFGKSATVAYPEGNWFPTSYYDVI-KENAERGLHTLLFLEAMELLLKVEDMKKGGVFTDDTLVVVLARAGSLNPTIRAGYVKDLIR--EDFGDPPHILIVPGKLHIVAEYLVEIA....................... 254
10 -53.7001wde_A mol:protein length:294 Probable diphthine synthase  ali model follow..  14  6......................EAVTLLLVGWGYAP-GMQTLEALDAVRRADVVYVESYTMPGSSWLYKSVVEAAGEARVVEASRRDLEERSREIVSRALDAV-VAVVTAGDPMVATTHSSLAAEALEAGVAVRYIPGVSGVQAARGATMLSFYRFGGTVTLPGPWRGVTPISVARRI-YLNLCAGLHTTALLQGVSLLLEADREYARELLARLPSVLVEAGAGGGHRVLYWSSLERLST--ADVEGGVYSIVIPARLSGVEWLLAAARPLEYDRSVYETVEENCKKGV... 289
11 -52.3004e16_A mol:protein length:253 precorrin-4 C(11)-methyltransferase  ali model follow..  25  4.......................MNKVHFVGAGPGDKELITLKGYKLLSNADVVIYGSLVNPELLEYCKEDCQIH------NSAHMDLQEIIDVMREGIENNKSVVRLQTGDFSIYGSIREQVEDLNKLNIDYDCTPGVSSFLGAASSLGVEYTVPEISQSV-IITRMEGRTPVPEKESIQSYAKHQTSMVIFLSVQEIEKVVSKLLEGGYPKDTPIAVIYKATWADEKIVKGTLSDIAVKVKENNINKTALIMVGRFLG................................ 234
12 -51.2001cbf_A mol:protein length:285 COBALT-PRECORRIN-4 TRANSMETHYLASE  ali model follow..  28  13......................SHMKLYIIGAGPGDPDLITVKGLKLLQQADVVLYDSLVSQDLIAKSKPGAEVL------KTAGMHLEEMVGTMLDRMREGKMVVRVHTGDPAMYGAIMEQMVLLKREGVDIEIVPGVTSVFAAAAAAEAELTIPDLTQTV-ILTRAEGRTPVPEFEKLTDLAKHKCTIALFLSSTLTKKVMKEFINAGWSEDTPVVVVYKATWPDEKIVRTTVKDLDDAMRTNGIRKQAMILAGWALD................................ 244
13 -47.2003nei_A mol:protein length:281 Precorrin-4 C(11)-methyltransferase  ali model follow..  25  16.........................TVHFIGAGPGAADLITIRGRDLIASCPVCLYGSLVPEALLAHCPPGAKIV------NTAPMSLDAIIDTIAEAHAAGQDVARLHSGDLSIWSAMGEQLRRLRALNIPYDVTPGVPSFAAAAATLGAELTLPGVAQSVILTRTSGRASAMPAGETLENFARTGAVLAIHLSVHVLDEVVQKLVP-HYGEDCPVAIVWRASWPDQRVVRATLATLQTSL-GAELERTALILVGRSLATED............................. 246
14 -32.1002e0k_A mol:protein length:259 Precorrin-2 C20-methyltransferase  ali model follow..  16  3......................NQGSIISVSLGPGDPGLITVKALSQLREADVIYYPGILKEFDLDPSKLRGMLVPMSRSRGAAEASYAANYASMAEEVQAGRRVAVVSVGDGGFYSTASAIIERARRDGLDCSMTPGIPAFIAAGSAAGMPLALQS--DSVLVLAQIDEIGELERAL------VTHSTVVVMKLSTVRDELVSFLERYAKP----FLYAEKVGMAGEFITME-----VDALRSRAIPYFSLLVC..................................... 232
15 -31.4002qbu_A mol:protein length:232 Precorrin-2 methyltransferase  ali model follow..  21  2.......................HGKLIGVGVGPGDSELLTLRAVNVLRSVPVICAPR-IVEDILTERRDGCRILDP-DDRDELESHWDSAARMVAAELEDGRDVAFITLGDPSIYSTFSYLQQRIEDMGFKTEMVPGVTSFTACAATAGRTLVEGD--EILLVVPRVDDR---------ERVLRDVDACVIMKTSRHGRRAMEVVESDPRGKD--VVSVANCSMDDEVVE............................................................. 211
16 -27.9002npn_A mol:protein length:251 Putative cobalamin synthesis related protein  ali model follow..  16  3........................RTIYVIGIGTGSPEFLTLQAISGLRHAQAIVA-LALRQKIVDTHAPGTPIYYEEEVRRWHAERAHLLASTIRERTPDDGAVAFLVWGDPSLYDSTLRIIEHMRNLEADVKVIPGITAVQVLTAEHGILIN--RIGEAIHITTGRNLPETSAKDRR--------NCVVMLDG--------KTAWQDVATEHTYMWWGAFLGTEQQVLRKGYVHEIGAQVAELK------------QQLRTEHGWIMDTY.................... 245
17 -27.9002zvb_A mol:protein length:295 Precorrin-3 C17-methyltransferase  ali model follow..  25  2........................GELFLVGMGPGDLPGLTQRAREALEGAEVVIYVKLLEEMGL----AGKEVVRKGMT------EELDRAEEALERALSGQRVALVSGGDPGIYGMAAPVLELMEERGVFLAVIPGVTAANAVASLLGSPLAHDTCLISLSDLL-----------TPWPLIGQGDFVVVLYNPQSKRRD-SAEILLEYRPKETPAALVKSAYRKRQEVALTTLEGL----REAEAGMLTTVVIGN................................... 245
18 -27.1003nut_A mol:protein length:251 Precorrin-3 methylase  ali model follow..  22  2.......................SGWVTVAGLGPGREDLVTPEVTAALAEATDIVYVARIAP------REGLTLHPTDNR------VELDRATHALEMAAEGRRVVVVSSGDPGVFAMASALFEALEAAGTEIRILPGITAMLAAAAAAGAPLGHDFCAINLS-----------DNLKPFEILARGDFAMAFYNPRSKSRP-VLEILREECEPGRLILFARAVTTPEQAISVVELRDA----TPEMADMRTVVLVGN................................... 227
19 -25.6003nd1_A mol:protein length:275 Precorrin-6A synthase/CobF protein  ali model follow..  16  9.................VPRGSHMIELSLIGIGTGNPRHITGQAVDAMNAADLILIAAHLTNPATKVIRDASNPSYRKGVDDWHDAIAETWLSEIAHVPGLEGRVALLVWGDPSLYDSTLRIAERLKSRPLTTKVIPGITAIQALCAAHAIPLND--IGAPVVITTGRQLRDHG-------WPAGTETVVAMLDGECSFQSL--------PPDGLTIFWGACVAMPEEVLIRGPVAEVTDEILQAR------------ADLRARHGWVMDIY.................... 260
20 -22.9003kwp_A mol:protein length:296 Predicted methyltransferase  ali model follow..  18  1.........QGHMEQQRSFQTETGGHLYLVPTPIGNLDDMTFRAVKTLTAVDLIA-DTRNTQKLLNHFEITTKQI------SFHEHNTQERIPQLIAKLKQGMQIAQVSAGMPSISDPGHELVNACIDAHIPVVPLPGANAGLTALIASGLAPQP--------YFYGFLDRKPKDRKAEIAGLAQRPETLIFYEAPHRLKKTLQNLAAG-FGDERPAVLCRELTKRYEEFLRGSLAELANWAATDTVRGEFVVLV..................................... 234
21 -16.9002bb3_A mol:protein length:221 cobalamin biosynthesis precorrin-6Y methylase  ali model follow..  16  18..........................IWIVGSGTCRGQT-TERAKEIIERAEVIY-----SRRALELAGVVDD----SRARILRSFKGDEIRRIMEE--GREREVAVISTGDPMVAGLGRVLREIAEDVEI--KIEPAISSVQVALARLKVDL------SEVAVVDCHAKDFDA------TELLKYRHLLILADSHFPLERLGKRRV----------VLLENLCMEGERIREGNADSIEL.................................................... 198
22 -15.3003hh1_A mol:protein length:117 Tetrapyrrole methylase family protein  ali model follow..  21  1...................SNAHKGTLYVVATPLGNLDDMTFRAVNTLRNAGAIA-DTRRTSILLKHFG-----IEGKRLVSYHSFNEERAVRQVIELLEEGSDVALVTAGTPAISDPGYTMASAAHAAGLPVVPVPG.......................................................................................................................................................... 116
23 -15.2001wyz_A mol:protein length:242 putative S-adenosylmethionine-dependent methy  ali model follow..  12  2.......................ETALYLLPVTLGDEQVLPSYNTEIIRGIRFIVEDVRSARRFLKKVDREIDIDSLTFYPLNKHTSPEDISGYLKPLAGGASMGVISEAGCPAVADPGADVVAIAQRQKLKVIPLVGPSSIILSVMASGFN------GQSFAF-HGYLPIEPGERAKKLKTLYAESQTQLFIETPYRNHKMIEDILQN-CRPQTKLCIAANITCEGEFIQTRTVKDWKGHIPELS-KIPCIFLLYK................................... 234
24 -10.4003fq6_A mol:protein length:115 Methyltransferase  ali model follow..  12  2.........................................................................................................................................NATAFVPALVASGLPNEK--------FCFEGFLPQKKGRQTRLKALAEEHRTMVFYESPHRLLKTLTQFAEY--GTERQATVSREISKLHEETVRGSLAELIEHFTATEPRGEIVIVLA.................................... 111
25 -10.4003ffy_A mol:protein length:115 Putative tetrapyrrole (Corrin/porphyrin) meth  ali model follow..  14  2.........................................................................................................................................NATAFVPALVASGLPNEK--------FCFEGFLPQKKGRMTKLKSLVDEHRTMVFYESPHRLLKTLTQFAEY--GPERQVSVSREISKIHEETVRGTLSELIEHFTATDPRGEIVIVLA.................................... 111

FFAS is supported by the NIH grant R01-GM087218-01
1 2 4 1 8 9   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Sasin JM, Godzik A, Bujnicki JM. SURF'S UP! - protein classification by surface comparisons. J Biosci. 2007 Jan;32(1):97-100.