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Query: [J] COG0008 Glutamyl- and glutaminyl-tRNA synthetases, from COG0516

Results of FFAS03 search in PDB0516
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MSEAEARPTNFIRQIIDEDLASGKHTTVHTRFPPEPNGYLHIGHAKSICLNFGIAQDYKGQCNLRFDDTNPVKEDIEYVESIKNDVEWLGFHWSGNVRYSSDYFDQLHAYAIELINKGLAYVDELTPEQIREYRGTLTQPGKNSPYRDRSVEENLALFEKMRAGGFEEGKACLRAKIDMASPFIVMRDPVLYRIKFAEHHQTGNKWCIYPMYDFTHCISDALEGITHSLCTLEFQDNRRLYDWVLDNITIPVHPRQYEFSRLNLEYTVMSKRKLNLLVTDKHVEGWDDPRMPTISGLRRRGYTAASIREFCKRIGVTKQDNTIEMASLESCIREDLNENAPRAMAVIDPVKLVIENYQGEGEMVTMPNHPNKPEMGSRQVPFSGEIWIDRADFREEANKQYKRLVLGKEVRLRNAYVIKAERVEKDAEGNITTIFCTYDADTLSKDPADGRKVKGVIHWVSAAHALPVEIRLYDRLFSVPNPGAADDFLSVINPESLVIKQGFAEPSLKDAVAGKAFQFEREGYFCLDSRHSTAEKPVFNRTVGLRDTWAKVGELast
1 -189.0001o0b_A mol:protein length:554 Glutaminyl-tRNA synthetase  ali model follow..  100  1MSEAEARPTNFIRQIIDEDLASGKHTTVHTRFPPEPNGYLHIGHAKSICLNFGIAQDYKGQCNLRFDDTNPVKEDIEYVESIKNDVEWLGFHWSGNVRYSSDYFDQLHAYAIELINKGLAYVDELTPEQIREYRGTLTQPGKNSPYRDRSVEENLALFEKMRAGGFEEGKACLRAKIDMASPFIVMRDPVLYRIKFAEHHQTGNKWCIYPMYDFTHCISDALEGITHSLCTLEFQDNRRLYDWVLDNITIPVHPRQYEFSRLNLEYTVMSKRKLNLLVTDKHVEGWDDPRMPTISGLRRRGYTAASIREFCKRIGVTKQDNTIEMASLESCIREDLNENAPRAMAVIDPVKLVIENYQGEGEMVTMPNHPNKPEMGSRQVPFSGEIWIDRADFREEANKQYKRLVLGKEVRLRNAYVIKAERVEKDAEGNITTIFCTYDADTLSKDPADGRKVKGVIHWVSAAHALPVEIRLYDRLFSVPNPGAADDFLSVINPESLVIKQGFAEPSLKDAVAGKAFQFEREGYFCLDSRHSTAEKPVFNRTVGLRDTWAKVGE 554
2 -188.0002rd2_A mol:protein length:556 Glutaminyl-tRNA synthetase  ali model follow..  99  1MSEAEARPTNFIRQIIDEDLASGKHTTVHTRFPPEPNGYLHIGHAKSICLNFGIAQDYKGQCNLRFDDTNPVKEDIEYVESIKNDVEWLGFHWSGNVRYSSDYFDQLHAYAIELINKGLAYVDELTPEQIREYRGTLTQPGKNSPYRDRSVEENLALFEKMRAGGFEEGKACLRAKIDMASPFIVMRDPVLYRIKFAEHHQTGNKWCIYPMYDFTHCISDALEGITHSLRTLEFQDNRRLYDWVLDNITIPVHPRQYEFSRLNLEYTVMSKRKLNLLVTDKHVEGWDDPRMPTISGLRRRGYTAASIREFCKRIGVTKQDNTIEMASLESCIREDLNENAPRAMAVIDPVKLVIENYQGEGEMVTMPNHPNKPEMGSRQVPFSGEIWIDRADFREEANKQYKRLVLGKEVRLRNAYVIKAERVEKDAEGNITTIFCTYDADTLSKDPADGRKVKGVIHWVSAAHALPVEIRLYDRLFSVPNPGAADDFLSVINPESLVIKQGFAEPSLKDAVAGKAFQFEREGYFCLDSRHSTAEKPVFNRTVGLRDTLE.... 550
3 -182.0005bnz_A mol:protein length:564 Glutamine--tRNA ligase  ali model follow..  60  5.KPETTAAPNFLRQIVQADLDAGKHAKIVTRFPPEPNGYLHIGHAKSICLNFGLAQEFAGDCHLRFDDTNPAKEDQEYIDAIEADIKWLGFQWSGEVCYASNYFDQLHAWAVELIKAGKAFVCDLGPEEMREYRGTLTEPGRNSPYRDRSVEENLDLFARMKAGEFPDGARSLRAKIDMGSPNMNLRDPILYRIRHAHHHQTGDKWCIYPSYDFTHGQSDAIEGITHSICTLEFEDHRPLYEWFLANLPVPAQPRQYEFSRLNLNYTVTSKRKLKQLVDEGHVSGWDDPRMSTLSGYRRRGYTPESIRNFCEMIGVNRASGVVDIGMLEFSIRDHLDATAPRAMCVLKPLKVVITNYEGQVENLELPRHPK-EDMGVRVLPFGRELFIDAGDFEEVPPAGYKRLIPGGEVRLRGSYVIRADEAIKDADGNIVELRCSYDPDTLGKNP-EGRKVKGVIHWVPAEGSVECEVRLYDRLFRSANPEEGGSFLDNINADSLQVLACRAEPSLGQANPEDRFQFEREGYFVADLKDSRPGKPVFNRTVTLRDSWGQ... 557
4 -182.0004p2b_A mol:protein length:576 Glutamine aminoacyl-tRNA synthetase  ali model follow..  52  8LVPRGSHMVNFLKQIVEEDLRTGKHKTVITRFPPEPNGFLHLGHAKSVCLNFGLAKAFGGRCHLRFDDTNPMKEETRYIESIQRDVRWLGGDWGNHLYYASDYFQQLYDWAELLIKKGLAFVDDDSLEEIRRKRGSISQPGENSPFRERSIEENLDLFRRMRAGEFEEGSRVLRAKIDMTHSNMNMRDPVLYRILKKEHPRTGNQWVIYPMYDYAHGQSDSIENITHSICTLEFDLHRILYDWFQEKLEIT-RTRQIEFARLNVTYTVMSKRKLLALVTEKWVDGWDDPRLPTLSGLRRRGVPPSALRDFCDKVGVARRESTIKVEVLEKCIRDALHVVAHRRFAIQDPIAVTITNYGDKVETITAANHPEDESFGTRELHFSKKLYIDRDDFMENPPAGYRRLAPGAEVRLKHAYWIKCVDVVKDASGLVTELLCTYDPQTKNCSVPDGRKVKGAIHWLSEKDAVPAEIRIFGRLFTKPNPEEEDSWRENINKESLKVYKGFVERSAADSAPQSSLQFERLGFFTPDGSTLPETLPVFNLTVALQ........ 570
5 -175.0002hz7_A mol:protein length:851 Glutaminyl-tRNA synthetase  ali model follow..  46  41.PAAPLVAPNFITEIIERDLEAGKYPRVVTRFPPDPSGYAHLGHVFASLLDFNTARQYGGQFNLRMDDTNPELARQEYVDSIADDLKWLGLDWGEHFYYASDYFDRYYAYAEQLIRQGDAYVESVSPEELSRLRGNATTPGTPSPYRDRSVEENLDLLRRMKAGEFADGEHVLRAKIDLTAPNMKLRDPVLYRIVNKPHFRTSDEWHIYPAYDFEHPLQDAIEGVTHSMCSLEFVDNRAIYDWLMEKLNFDPRPHQYEFGRRGLEYTITSKRKLRELVQAGRVSGWDDPRMPTLRAQRRLGVTPEAVRAFAAQIGVSRTNRTVDIAVYENAVRDDLNHRAPRVMAVLDPVKVTLTNLGEKTLSLPYGGGRVAPEEAVRDVPLTRELYIERDDFSPAPPKGFKRLTPGGTVRLRGAGIIRADDFGTDEAGQVTHIRATLLGED--------AKAAGVIHWVSAERALPAEFRLYDRLFRVPHPEVSQGFMRYLTPDSLRVLRGYVEPSVAGDPADTRYQFERQGYFWRDPVDSREDALVFGRIITLKDTWGKQGG 636
6 -149.0004h3s_A mol:protein length:817 Glutamine-tRNA ligase  ali model follow..  42  228..HKVGENPQAYPELMKEHLEVTG-GKVRTRFPPEPNGYLHIGHSKAIMVNFGYAKYHNGTCYLRFDDTNPEKEAPEYFESIKRMVSWLGFKP-WKITYSSDYFDELYRLAEVLIKNGKAYVCHCTAEEIKRGRGIKEDERYACKHRDQSIEQNLQEFRDMRDGKYKPGEAILRMKQDLNSPSPQMWDLIAYRVLNAPHPRTGTKWRIYPTYDFTHCLVDSMENITHSLCTTEFYLSRESYEWLCDQVHV-FRPAQREYGRLNITGTVLSKRKIAQLVDEKFVRGWDDPRLFTLEAIRRRGVPPGAILSFINTLGVTTSTTNIQVVRFESAVRKYLEDTTPRLMFVLDPVEVVVDNLDDYEELATIPYRPGTPEFGERTVPFTNKFYIERSDFSENDDKEFFRLTPNQPVGLKVSHTVSFKSLEKDEAGKIIRIHVNYDNKVEEGS--KPKKPKTYIQWVPISSKYNSETRVYNQLFKSENPSSPEGFLKDINPESEVVYKSVMEHNFGDSKEVCRFQAMRVGYFTLD-KESTTSKVILNRIVSLKDATSKSGL 812
7 -142.0004r3z_C mol:protein length:799 Glutamine--tRNA ligase  ali model follow..  45  257.KTPGYVVTPHTMNLLKQHLEITG-GQVRTRFPPEPNGILHIGHAKAINFNFGYAKANNGICFLRFDDTNPEKEEAKFFTAICDMVAWLGYTP-YKVTYASDYFDQLYAWAVELIRRGLAYVCHQRGEELKGHNTL------PSPWRDRPMEESLLLFEAMRKGKFSEGEATLRMKLVMEDGKM---DPVAYRVKYTPHHRTGDKWCIYPTYDYTHCLCDSIEHITHSLCTKEFQARRSSYFWLCNALDV-YCPVQWEYGRLNLHYAVVSKRKILQLVATGAVRDWDDPRLFTLTALRRRGFPPEAINNFCARVGVTVAQTTMEPHLLEACVRDVLNDTAPRAMAVLESLRVIITNFAAKSLDIQVPNFPADETKGFHQVPFAPIVFIERTDFKEEPEPGFKRLAWGQPVGLRHGYVIELQHVVKGPSGCVESLEVTCRRAD------AGEKPKAFIHWVS--QPLMCEVRLYERLFQHKNPEDPGGFLSDLNLASLHVVDALVDCSVALAKPFDKFQFERLGYFSVD-PDSHQGKLVFNRTVTLKEDPGKV.. 793
8 -120.0003aii_A mol:protein length:553 Glutamyl-tRNA synthetase  ali model follow..  31  73..GLEITERKQKKRKGLRELA-GVKGEVVLRFAPNPSGPLHIGHARAAILNHEYARKYDGRLILRIEDTDPRRVDPEAYDMIPADLEWLGVEW-DETVIQSDRMETYYEYTEKLIERGGAYVCTCRPEEFRELK----NRGEACHCRSLGFRENLQRWREMF--EMKEGSAVVRVKTDLNHPNPAIRDWVSMRIVEAEHPRTGTRYRVYPMMNFSVAVDDHLLGVTHVLRGKDHLANREKQEYLYRHLGWE-PPEFIHYGRLKMDDVALSTSGAREGILRGEYSGWDDPRLGTLRAIARRGIRPEAIRKLMVEIGVKIADSTMSWKKIYGLNRSILEEEARRYFFAADPVKLEVVGLPGP-VRVERPLHPDHPEIGNRVLELRGEVYLPGDDLGEGP------------LRLIDAVNVIYS-------GGELRYHSEGIEEAR-------ELGASMIHWVPAESALEAEVIMPDASR----------------------VRGVIEADASELEVDDVVQLERFGFARLDSAGPG..................... 545
9 -29.7002cfo_A mol:protein length:492 GLUTAMYL-TRNA SYNTHETASE  ali model follow..  21  1..........................TVRVRLAPSPTGNLHIGTARTAVFNWLYARHRGGKFILRIEDTDRERSRPEYTENILEGLQWLGLTWDEGPYFQSDRLDLYRQAIQTLLDKGLAYYCYCTPEELEALRAEQKAKGQAPRYDNRHRHLT----EEQAAFEAAGRTPVIRFKIE-DDRQIEWQDLVRGRVSWQGADLGGDMVIAYPLYNLVVVVDDIAMGITDVIRGEDHIGNTPKQILLYEALGATPPNFAHTPLILNSTGQKLSKRDGVTSISD----------------FRAMGYLAPALANYMTLLGWSPPEGVGELFTLDLAAKHFSFERINKAGARFDWDKLNWLN-QLEPEEFLAELIPLWQGAGYAFDEERDRPWLFD-QLLQPGLNTLREAIDQGAVFFIPSVTFDSEAMAQLGQPQSATILAYLLEHLPAEPALTVAMGQQLIQQAAKAAGVKKG..................................................................................... 437
10 -27.9004gri_A mol:protein length:512 Glutamate--tRNA ligase  ali model follow..  15  17.........................LSTRVRYAPSPTGLQHIGGIRTALFNYFFAKSCGGKFLLRIEDTDQSRYSPEAENDLYSSLKWLGISFDEGPYVQSQRSAIYKQYAKYLIESGHAYYCYCSPERLERIKKIQNINKMPPGYRNLSNEE---VENALIKKI----KPVVRFKIP-LEGDTSFDDILLGRITWANKDISPDPVILLPTYHLANVVDDYLMKITHVLRAQEWVSSGPLHVLLYKAFKWKPPIYCHLPMVMGNDGQKLSKRHGSTALRQ----------------FIEDGYLPEAIINYVTLLGWSYDDKR-EFFSKNDLEQFFSIEKINKSPAIFDYHKLDFFNSY---------REKKDEDLFNLLLPFFQKKGYVSKPSTLEENQKLKLLIPLIKSRIKKSWNLDEFLSRKKTAKEVCSILELIKPILEGFEKRSSEENDKIFYDFAESNGFKLGEILLPIRIAALGSKVSPPLFDSLKLIGKSKVFERIKLAQEFLRINE....................................... 506
11 -27.7004g6z_A mol:protein length:490 Glutamate-tRNA ligase  ali model follow..  23  18.........................RPVRTRFAPSPTGFIHLGNIRSALYPWAFARKMKGTFVLRIEDTDVERSSQEAVDAILEGMAWLGLDYDEGPYYQMQRMDRYREVLAQMQEKGLVYPCYMSTEELDALRERQRAAGEKPRYDGTWRPEPGKVLPEPPAGV-LTGTVAWDDAVRVEISNEELDDLVVAR---------------TPMYNFCVVVDDLDMGITHVIRGDDHVNNTPRQINILRALGGEVPVYAHLPTVLNEQGEKMSKRH-----------------AMSVMGYRDAGYLPEAVLNYLARLGWSHGDA--EIFTREQFVEWFDLEHLGKSPAQYDHNKLNWLN...................................................................................................................................................................................................... 328
12 -27.0002o5r_A mol:protein length:481 Glutamyl-tRNA synthetase 1  ali model follow..  23  2.....................GSDKIMVRVRFAPSPTGFLHVGGARTALFNFLFARKEKGKFILRIEDTDLERSEREYEEKLMESLRWLGLLWDEGPYRQSERVEIYREHAERLVKEGKAYYVYAYPEEIEEMREKLLSEGKAPHYSQEMFEKFDT--ERRREYEEKGLRPAVFFKMEVVFKTGAIGDFVIMR---------------LPTYNFACVVDDMLMEITHVIRGDDHLSNTLRQLALYEAFEKAPPVFAHVSTILGPDGKKLSKRHGATSVEA----------------FRDMGYLPEALVNYLALLGWSHPEGK-ELLTLEELISSFSLDRLSPNPAIFDPQKLKWMN...................................................................................................................................................................................................... 327
13 -25.2001g59_A mol:protein length:468 GLUTAMYL-TRNA SYNTHETASE  ali model follow..  18  2...........................VVTRIAPSPTGDPHVGTAYIALFNYAWARRNGGRFIVRIEDTDRARYVPGAEERILAALKWLGLSYDEGPYRQSERLPLYQKYAEELLKRGWAYRAFETPEELEQIRK--EKGGYDGRARNIPPEE---AEERARRGE----PHVIRLKVVVVYDNQEIPDVVLLK---------------YPTYHLANVVDDHLMGVTDVIRAEEWLVSTPIHVLLYRAFGWEAPRFYHMPLLRNPDKTKISKRK------------------TSLDWYKAEGFLPEALRNYLCLMGFSMPDGR-EIFTLEEFIQAFTWERVSLGGPVFDLEKLRWMNGKYIREVLSL------EEVAERVKPFLREAGLSWESLRRAVELMRPRFDTLKEFPEKARYLYPVSEKAQRKLEEGLPLLKELYPRLRAQEEWTEAALEALLRGFAAEKGVKLGQVAQPLRAALTGSLETPGLFEILALLGKERALRRLERALA............................................. 468
14 -24.9003pnv_A mol:protein length:505 Glutamyl-tRNA synthetase  ali model follow..  19  14.........................ETVRVRFCPSPTGTPHVGLVRTALFNWAYARHTGGTFVFRIEDTDAQRDSEESYLALLDALRWLGLDWDEGPYRQSQRAEIYRDVLARLLAAGEAYHAFSTPEEVHVAAGRNPKLGYDNFDRHLTDAQRAAYLAEGRQ-RMPDDD-LVRGPVTFAAGSVP--DFALTR---------------DPLYTLVNPCDDALMKITH---VLRGEDL------------LPSTPRQLALIRIGVAERIPKFAHLPTVLGEGTKKLSKRDPQSNLFAHRDRGFIPEGLLNYLALLGWSIADDH-DLFGLDEMVAAFDVADVNSSPARFDQKKADALN...................................................................................................................................................................................................... 337
15 -24.5002ja2_A mol:protein length:498 GLUTAMYL-TRNA SYNTHETASE  ali model follow..  19  5.........................ETVRVRFCPSPTGTPHVGLVRTALFNWAYARHTGGTFVFRIEDTDAQRDSEESYLALLDALRWLGLDWDEGPYRQSQRAEIYRDVLARLLAAGEAYHAFSTPEEVHVAAGRNPKLGYDNFDRHLTDAQRAAYLAEGRQ-RMPDDDLAWNDLVPVTFAAGSVPDFALTR---------------DPLYTLVNPCDDALMKITH---VLRGEDL------------LPSTPRQLALIRIGVAERIPKFAHLPTVLGEGTKKLSKRDPQSNLFAHRDRGFIPEGLLNYLALLGWSIADDH-DLFGLDEMVAAFDVADVNSSPARFDQKKADALN...................................................................................................................................................................................................... 328
16 -23.4003al0_C mol:protein length:592 Glutamyl-tRNA(Gln) amidotransferase subunit C  ali model follow..  19  128.........................ELVRVRFAPSPTGHLHVGGARTALFNWMFARKEGGKFILRIEDTDTERSSREYEQQILESLRWCGLDWDEGPYRQSERLEIYREYAEKLVEDKRAYYVVYDKEDPSKELFTTYEYPHEYKEKGHPVTIKFKV---------LPGKTSFEDLLYMEFDNSTLEDFIIMK---------------FPTYNFAVVVDDHLMRISHVFRGEDHLSNTPKQLMIYEAFGWEAPVFMHIPLILGSDRTPLSKRHGATSVEH----------------FRREGILSRALMNYLALLGWRVEGD--EIFTIEEKLQSFDPKDISNKGVIFDYQKLEWVN...................................................................................................................................................................................................... 429
17 -20.0001nzj_A mol:protein length:298 Hypothetical protein yadB  ali model follow..  22  9..............................RFAPSPSGELHFGSLIAALGSYLQARARQGRWLVRIEDIDPPREVPGAAETILRQLEHYGLHWDGDVLWQSQRHDAYREALAWLHEQGLSYYCTCTRARIQSIGGVLHHGPDNAAVRIRQQHPVTQFTDQLR------GIIHADEKLAREDFIIHRRDGLF-------------------AYNLAVVVDDHFQGVTEIVRGADLIEPTVRQISLYQLFGWKVPDYIHLPLALNPQGAKLSKQNHAPALPK------GDPRPVLIAALQFLGQQAEA........................................................................................................................................................................................................................................................ 260

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Sasin JM, Godzik A, Bujnicki JM. SURF'S UP! - protein classification by surface comparisons. J Biosci. 2007 Jan;32(1):97-100.