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Query: [J] COG0013 Alanyl-tRNA synthetase, from COG1018

Results of FFAS03 search in PDB1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MKTMTSAEVRQMFLDFFKSKGHTVEPSQSLVPVNDPTLLWINSGVATLKKYFDGSVVPENPRLTNAQKAIRTNDIENVGKTARHHTMFEMLGNFSIGDYFRKEAIAFAWELLTSSEWFEFPAEKLYITYYPADKDTYNRWVEVGVDPTHLVPIEDNFWEIGAGPSGPDTEIFFDRGEVYDPEHVGLKLLAEDIENDRYIEIWNIVLSQFNADPSIPRSEYPELPQKNIDTGMGLERMVCIIQGGKTNFDTDLFLPIIREIEKLSGKTYSPDSENMSFKVIADHIRSLSFAIGDGALPGNEGRGYVLRRLLRRAVMHGKKLGIQGKFLASLVPTVGKIMQSYYPEVLEKEDFIMQIIDREEETFNRTIDAGQKLIDELLLNLKSEGKDRLEGADIFRLYDTYGFPVELTEELAEDEGFKIDHEGFKVAMKAQQERARAAVVKGGSMGAQNETLSSIEVESEFLYEDKTTQGKLLVSIQDDEIVDEVSGKAQLVFDVTPFYAEMGGQVADHGVIKDAEGQVVANVLDVQHAPHGQNLHSVETLSPLKVGESYTLEIDKERRAAVVKNHTATHLLHAALHNIVGNHALQAGSLNEVEFLRFDFTHFAQVTKEELAEIERQVNEVIWQSLKVETVETDIATAKEMGAMALFGEKYGKNVRVVKIGDYSIELCGGTHTQTTSEIGLFKIVKEEGIGSGVRRIIAVTGQKAYEAFKDAENTLNEVATMVKAPQTSQVLAKVTSLQDELKTAQKENDALAGKLAASQSDEIFKNVQTAGSLNFIASEVTVPDANGLRNLADIWKQKELSDVLVLVAKIGEKVSLLVASKSSDVKAGNLVKELAPFVDGRGGGKPDMAMAGGSKAAGIPELLAAVAEKLALast
1 -158.0002zze_A mol:protein length:752 Alanyl-tRNA synthetase  ali model follow..  27  55.RKYTLDEMREKFLRFFEKHPHGRVKRYPVLPRWRDDVLLVGASIMDFQPWVIGEADPPANPLVISQPSIRFTDIDNVGITGRHFTIFEMMAHHAFNYYWMDETVELAFEFFT--KELKMKPEDITF--------------------------KENPWAGG-GNAGPAFEVLYR-----------------------GLEVATLVFMQYKKAPENAGEKYIPMETKVVDTGYGLERLVWMSQGTPTAYDAVLG-YVVEPLKKMAGIEKIDEKPYELIYAIADHTKALTFMLADGVVPSNVKAGYLARLLIRKSIRHLRELGLEVPLS-EIVALHIKELHKTFPEFKEMEDIILEMIELEEKKYAETLRRGSDLVRREIAKLKKKGIKEIPVEKLVTFYESHGLTPEIVKEIAEKEGVKVNIPDNFYSMVAKEAERTKEEKGEE--LVDFELLKDLPDTRRLYYEDPFMKEFDAKVLR--------VIKDWVILDATAFYPEGGGQPYDTGVLIVNGR--EVKVTNVQKVGK-VIIHKVEDPGAFKEGMIVHGKIDWKRRIQHMRHHTGTHVLMGALVRVLGRHVWQAGSQLTTDWARLDISHYKRISEEELKEIEMLANRIVMEDRKVTWEWLPRTTAEQKYGFRLYGVVPGREIRVVKIEDWDVQACGGTHLPSTGLVGPIKILRTERIQDGVERIIFACGE......................................................................................................................................................................... 752
2 -149.0003wqy_A mol:protein length:906 Alanine--tRNA ligase  ali model follow..  24  58.KPFELDEMREYYLNFFERRGHGRIERYPVVARWRTDIYLTIASIADFQPFVTGVAPPPANPLTISQPCIRLDDLDSVGRTGRHLTLFEMMAHHAFNYYWKNETVAYCTELLN----------------------------ELGVKKEDIV-YKEEPWAGG-GNAGPCLEAIVGGLEGARYRKMDNYIVDTGYGLERFVWASKGTPTVYDAI-DTIIDNSNVSFNREDERVRRIVAESSKLAGIMGELRGERLNQLRKSVADTVGVSVEEVVPLEKVYSLADHTRCILFMLGDGLVPSNAGAGYLARLMIRRSLRLAEELEL-GLDLYDLVEMHKKILGFEFDVPLST---VQEILELEKERYRTTVSKGTRLVERLVERKK-----KLEKDDLIELYDSHGIPVELAVGIAAEKGAEVEMPKDIYAELAKRHSKAEKVQEKKI-----TLQNEYPATEKLYYDDPTLLEFEAEVIG--------VEGDFVILNRSAFYPESGGQDNDVGYLIANGGK--FEVVDVLEADGVVLHV--VKGAKPEVGTKVKGVIDSDVRWRHMRHHSATHVLLYSLQKVLGNHVWQAGARKEFSKARLDVTHFRRPSEEEIKEIEMLANREILANKPIKWEWMDRIEAERKFGFRLYGVPPGRKIRVVQVG-DDVQACGGTHCRSTGEIGMLKILKVESIQDGVIRFEFAAGEAAIEAVEEMERLLREASSILRVE-PAKLPKTVERFFEEWKDQRKEIERLKSVIADLWADILMERAEEFDSMKVVAEVVD-ADMQALQKLAERLAEK--GAVGCLMAKGEGKVFVVTFSGQ-KYDARELLREIGRVAKGSGGGRKDVAQGAVQQLLDREEMLDVIFRFLS 902
3 -125.0001riq_A mol:protein length:465 Alanyl-tRNA synthetase  ali model follow..  43  2..SLSAHEIRELFLSFFEKKGHTRVKSAPLVPENDPTLLFVNAGMVPFKNVFLGLEKRPYKRATSCQKCLRVNDLEQVGYTSRHHTFFEMLGNFSFGDYFKKEAIEYAWEFVT--EVLKLPKEKLYVSVYKDDEEAYRIWNEIGIPSERIWRLEDNFWQMGVGPCGPSSEIYVDRGEE-------------YEGDERYLEIWNLVFMQYNRDE---NGVLTPLPHPNIDTGMGLERIASVLQGKNSNFEIDIIFPLIQFGEEVSGKKYGEKETDVALRVIADHLRAITFAISDGVIPSNEGRGYVIRRILRRAMRFGYKLGIENPFLYKGVDLVVDIMKEPYPELELSREFVKGIVKGEEKRFIKTLKAGMEYIQEVIQKALEEGRKTLSGKEVFTAYDTYGFPVDLIDEIAREKGLGIDLEGFQCELEEQRERARKHFKVEAKKPVYSHLKELGKTSAFVGAAALE..................................................................................................................................................................................................................................................................................................................................................................................................................... 459
4 -121.0003hxu_A mol:protein length:441 Alanyl-tRNA synthetase  ali model follow..  47  1..SKSTAEIRQAFLDFFHSKGHQVVASSSLVPHNDPTLLFTNAGMNQFKDVFLGLDKRNYSRATTSQRCVRANDLENVGYTARHHTFFEMLGNFSFGDYFKLDAILFAWLLLTSEKWFALPKERLWVTVYESDDEAYEIWKEVGIPRERIIRISDNFWQMGTGPCGPCTEIFYDHGDHIW----GGPPGSPEEDGDRYIEIWNIVFMQFNRQA---DGTMEPLPKPSVDTGMGLERIAAVLQHVNSNYDIDLFRTLIQAVAKVTGATD---LSNKSLRVIADHIRSCAFLIADGVMPSNENRGYVLRRIIRRAVRHGNMLGAKETFFYKLVGPLIDVMGSAGEDLKRQQAQVEQVLKTEEEQFARTLERGLALLDEELAK---LSGDTLDGETAFRLYDTYGFPVDLTADVCRERNIKVDEAGFEAAMEEQRRRAREASG................................................................................................................................................................................................................................................................................................................................................................................................................................................ 440
5 -120.0004xem_A mol:protein length:475 Alanine--tRNA ligase, cytoplasmic  ali model follow..  40  17.STLTASEIRQRFIDFFKRNEHTYVHSSATIPLDDPTLLFANAGMNQFKPIFLNTIDPSHSRAANTQKCIRANDLDDVGKDVYHHTFFEMLGSWSFGDYFKELACKMALELLT--QEFGIPIERLYVTYFGGDLECKQIWQNLGLDDTKILPGKDNFWEMGTGPCGPCSEIHYDRIGGRDAAH------LVNQDDPNVLEIWNLVFIQYNREA---DGILKPLPKKSIDTGMGLERLVSVLQNKMSNYDTDLFVPYFEAIQKGTGARPDADGIDMAYRVLADHARTITVALADGGRPDNTGRGYVLRRILRRAVRYAHELNASRGFFATLVDVVVQSLGDAFPELKKDPDMVKDIINEEEVQFLKTLSRGRRILDRKIQSLG--DSKTIPGDTAWLLYDTYGFPVDLTGLIAEEKGLVVDMDGFEEERKLAQLKSQGK.................................................................................................................................................................................................................................................................................................................................................................................................................................................. 469
6 -59.2005f5w_A mol:protein length:299 Glycine--tRNA ligase alpha subunit  ali model follow..  15  6FQSMYFQDIIMTLHKFWAEKGCLIWQPYDVEVGAGTMNPAT----------FLKVLGKKPWNVAYVEPSRRPQD-------GRYGENPNRLQHYYQFQVILKPAPRNPQEIYLE-ERLGINPLEHDIRF------------------------VEDDWESPTGAWGLGWEVWLD------------------------MEITQFTYFQQAGGL--------DLDEISVEITYGLERIAMYIQDKDSVFDIEWKEGIYEMFEKESKRMVEEGLIFPAYDYLLKCSHVFNILDARGAISVQERARYIRR--MNNLAREIAKLYLQV.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 286
7 -58.9001j5w_A mol:protein length:298 Glycyl-tRNA synthetase alpha chain  ali model follow..  16  5.KIMYLQDVIMKLNDFWASKGCLLEQPYDMEV-----------GAGTFHPTFFGSLRKGPWKVAYVQPSRRPTDGRY------GENPNRLQRYFQYQVIIKPSPENSQELYLESLEYLGINLKE------------------------HDIRFVEDNWESPTGAWGVGWEVWLD------------------------MEITQFTYFQQIGG--------ISLKDIPLEITYGLERIAMYLQGVDNVYEVQWNENVFDEYEKEFYRLVEKNLYLPAYDYILKCSHTFNLLDARGAISVSQRQTYVKR--IQAMARKAARVFLEV.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 284
8 -58.3002e1b_A mol:protein length:216 216aa long hypothetical alanyl-tRNA synthetase  ali model follow..  30  3.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................NMTRKLYYEDKEAKGRVLEI-----------RDNAILLDQTIFYPTGGGQPHDRGTING------VEVLDVYKDEEGNVWHVVKEPEKFKVGDEVELKIDWDYRYKLMRIHTGLHLLEHVLNEVLGEGNWQVGSGMSVEKGRYDIAYPENLN-KYKEQIISLFNKYVDEGGEVKI-------------------WWEGDRRYTQIRDFEVIPCGGTHVKDIKEIGHIKKLKRSSIGRGKQRLEMWL........................................................................................................................................................................... 215
9 -56.0001v7o_A mol:protein length:165 alanyl-tRNA synthetase  ali model follow..  23  2..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................YSIEVRTHSALHVVKGAVVKVLGSEAKWTYSYVKGNKGVLIVKFDRKPSDEEIREIERLANEKVKENAPIKIYELPREEAEKMFGEDMYDPEDVRILKVVVIEDWNVNACNKEHTKTTGEIGPIKIRKRFRKSKGLLEIHFELLELENPSLE.................................................................................................................................................................. 159
10 -55.0003rf1_A mol:protein length:311 Glycyl-tRNA synthetase alpha subunit  ali model follow..  10  17.NAMTFSQMILNLQNYWQEQGCAIMQPYDMPAGAGTFHPAT----------FLRSLGKKPWAAAYVAPSRRPTDGENPNRLGAYYQFQVLIK------PSPDNIQELYLKSLEN--------------------------LGFDLKSHDIRFVEDNWESPSLGAWGLGWEVWLD------------------------MEVTQFTYFQQVGG--------IAVDLVSAEITYGLERIAMYLQNVDNVYDIKILNEQFENSYKECKNILEQGLALPAYDYCMLAAHTFNLLDARGAISVAQRQDYMLK--IRELSKNCAEIYKKN.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 300
11 -54.5003kew_A mol:protein length:241 DHHA1 domain protein  ali model follow..  24  2........................................................................................................................................................................................................................................................................................................................................................................................................................................................................SLTKLYYEDQYIKEFKGEIIE----VKEIDGKFHVLLDQTAFFPGGGGQMGDLGLIDG------IKVLDVYEEEGKVYH---VLEKEPKKLKNLQCELDWERRFDGMQQHLGQHLLSGCFYDLFGANT--CGFHLGKEISTVDIVG--FLDEKTIREAEKEANRLIFENLEVKSYAPSKKELKKVKTRRAL-PKTDEEIRIVEIVGLDLNACCGVHPRNTRDLQVIKIRRWEKH-KNATRIEYVAGNRAVSE.................................................................................................................................................................... 234
12 -53.6003rhu_A mol:protein length:160 SC_1wnu  ali model follow..  22  2..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................YSIEVRTHSALHVVKGAVVKTAGSDAKTTSTYVKGNKGVLIVKAALEPDKWGIAAIEALANEKVKENAPIKIYELPREEAEKMFGEDMYDPEDVRILKVVVIEDWNVNACNKEHTKTTGEIGPIKIRKRFRKSKGLLEIHFELLEL........................................................................................................................................................................ 153
13 -52.0003rfn_A mol:protein length:159 BB_1wnu_001  ali model follow..  22  2...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................SIEVRTHSALHVVKGAVVKAAGSAAKTTSTYVKGNKGVLIVKAALELDKWAWAAMEALANEKVKENAPIKIYELPREEAEKMFGEDMYDPEDVRILKVVVIEDWNVNACNKEHTKTTGEIGPIKIRKRFRKSKGLLEIHFELLEL........................................................................................................................................................................ 152
14 -36.3005t5s_A mol:protein length:215 Alanine--tRNA ligase, cytoplasmic  ali model follow..  14  1....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................GAEAQKALRKAESLKKCLSVMEAKVKAQTAPNKDVQRE-IADLGEALATAQKDELRETLKSLKKVMDDLDRASKADVQKRVLEKTKQFIDS--NPNQPLVILEMESGATAKALNEALKLFKMHSPQTSAMLFTVEAGKITCLCQVPQNGLKASEWVQQVSGLMDGKGGGKDVSAQATGKNVGCLQEALQLATSFAQ 204
15 -35.5003g98_A mol:protein length:111 Alanyl-tRNA synthetase  ali model follow..  25  2..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................KEENVGDFTLHYGVFEEVEPEELRNLADMLRQRTKKDVVFIASRKGDKINFVIGVSKEKVNAKEVIREVGKVLKGGGGGRADLAQGGGKAPDKFPEAVKLLKEILS 110
16 -12.1004v1a_c mol:protein length:334 MITORIBOSOMAL PROTEIN ML39, MRPL39  ali model follow..  12  45.......................................................................................................................................................................................................................................................................................................................................................................................................................................FNKEKNRQLSLTPRTEKIE------------------VKHVGKTDPGTVFVMNKNISTPYSCAMHLSEWYCRKSILALVDGQPWDMYKPLTKSCEIKF----------------------------LTFKDDDPGEVNKAYWRSCAMMMGCVIERAFKDEYVVSLV-VIAGAFCYDVVLDKMPTKENLHSFTKDARALIYKDLPFETLEVEAKVALE-----IFQHN-ERIVKLHRFGDF-IDVSEGPLIPRTSICFQYEVSAVHNLQTQSSLVRRFQGLSLPVHLRAHFTIWNKLLERSRKMVTEDK............................................................................................................................................. 324

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Alonso A, Rahmouni S, Williams S, van Stipdonk M, Jaroszewski L, Godzik A, Abraham RT, Schoenberger SP, Mustelin T. Tyrosine phosphorylation of VHR phosphatase by ZAP-70. Nat Immunol. 2003 Jan;4(1):44-8. Epub 2002 Nov 25.