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Query: [J] COG0016 Phenylalanyl-tRNA synthetase alpha subunit, from COG1018

Results of FFAS03 search in SCOP207
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MREQLEALRDDAIKKIEQAQEKKVVQEIRVKYLGKKGPVTEVLRGMGKLSPEERPVIGQLANDVREAIGKAIESKMEALEQAEIHRKLQEETIDVTLPGRPVLKGGAHPLTATITEVEDLFIGLGFSVAEGPQIETDYYNFEALNLPKDHPARDMQDSFYFTDELLLRTQTSPVQARTMEKYKGKGPIKIICPGKVFRRDDDDATHSHQFMQIEGLYVDHGVRMSDLKGVLQAFAKSFFGEERSIRLRPSFFPFTEPSVEVDVSCGICHGDGCRVCKQTGWIEILGAGMVHPRVLEMSGFNPNEYSGFAFGMGVERLSMLKYGIDDIRHFYTNDRRFLAQFKRVLast
1 -106.000d1jjca_ d.104.1.1 (A:) Phenyl-tRNA synthetase (PheRS) alpha subunit, PheS {Thermus thermophilus [TaxId: 274]}  ali model 3D-neighbors follow..  40  1...........................................................................................RVDVSLPGASLFSGGLHPITLMERELVEIFRALGYQAVEGPEVESEFFNFDALNIPEHHPARDMWDTFWLTGEGFRLEGTHTSPMQVRYMVAHTPPFRIVVPGRVFRFEQTDATHEAVFHQLEGLVVGEGIAMAHLKGAIYELAQALFGPDSKVRFQPVYFPFVEPGAQFAVWWPEG----------GKWLELGGAGMVHPKVFQAVDAYREGVTGFAFGLGVERLAMLRYGIPDIRYFFGGRLKFLEQFKGV 265
2 -23.900d3pcoc1 a.2.7.0 (C:5-90) automated matches {Escherichia coli [TaxId: 562]}  ali model 3D-neighbors follow..  33  1.....AELVASAKAAISQASDVAALDNVRVEYLGKKGHLTLQMTTLRELPPEERPAAGAVINEAKEQVQQALNARKAELESAALNARLAAE............................................................................................................................................................................................................................................................. 86
3 -18.600d2iy5a1 a.2.7.2 (A:15-84) Phenylalanyl-tRNA synthetase (PheRS) {Thermus thermophilus [TaxId: 274]}  ali model 3D-neighbors follow..  34  1.....................LEELKALKARYLGKKGLLTQEMKGLSALPLEERRKRGQELNAIKAALEAALEAREKALEEAALKEALERE............................................................................................................................................................................................................................................................. 70
4 -16.000d3p8ta_ d.104.1.1 (A:) automated matches {Pyrococcus abyssi [TaxId: 29292]}  ali model 3D-neighbors follow..  15  19..............................................................................................................TKILDYMTKFFTDRGFKWLLPIMLSPI----DPLWPDPAGEGIRPAEVDVYGVRMRLTHSMILHKQLAIAMGLE----KIFVLSPNIRLESRDGRHSYEFTQLDFEIE---AKMKDVMRLIEELIYGLFRKAEEVNIPREFYDREENGVWKNYDLILPYGYG----------EVSSGGE---AKIRAAGLKEDSFRPYGAGIGVERLVRFIVGAKHIAEV.............. 281
5 -14.900d1l0wa3 d.104.1.1 (A:105-294,A:415-580) Aspartyl-tRNA synthetase (AspRS) {Thermus thermophilus, AspRS-1 [TaxId: 274]}  ali model 3D-neighbors follow..  15  16...............................................................................KEASEELRLKYRYLDLRRRRMQ---ENLRLRHRVIKAIWDFLDREGFVQVETPFLTKSTPEGARDFLVPYRHEPGLF--YALPQSPQL----------FKQMLMVAGLDRYFQIARCFRDEDLRADRQPDFTQLD--LEMSFVEVEDVLELNERLMAHVFREALGVELPLPFFTSPHPEDLPLLEKDPGRVRALAYDLVLNGVEVGGGSILQARVFRLLGIGEEEQREKGIAWGLDRLLALMTGSPSIREV.............. 322
6 -14.900d4j15a2 d.104.1.0 (A:153-495) automated matches {Human (Homo sapiens) [TaxId: 9606]}  ali model 3D-neighbors follow..  15  48..............................................................................................................SGICHLFRETLINKGFVEIQTPKIISA----------ASEGGANVFTVSYFKNNAYLAQSPQLYKQMCICADFE----KVFSIGPVFRAEDSNTHHLTEFVGLD-IEMAFNYHYHEVMEEIADTMVQIFKQTVNKQFPCEPFKFLEPTLRLEYC-AMLREAGVEMGDEDDL-EILSGAQLLTERALHHGIDLEKIKAYGGGIGLERVTMLFLGLHNVRQMFPRD.......... 343
7 -14.100d3nema2 d.104.1.0 (A:103-316,A:317-438) automated matches {Thermococcus kodakarensis [TaxId: 311400]}  ali model 3D-neighbors follow..  16  39..............................................................................................................SSVFKAVRDFFHENGFIEIHTPKIIAT----------ATEGGTELFPMKYFEEDAFLAQSPQLYKQIMMASGLD----RVYEIAPIFRAEEHNTTHLNEAWSID-SEMAFIEDEEEVMSFLERLVAHAINDILNFELEEPKLPFPRVSYDKALEILGDLGKEIPWGEDID--EISSGGQILVEQIKEKGLNPESFEFYGFGLGAERLIKQMLDLPNIREV.............. 325
8 -13.900d1x54a2 d.104.1.0 (A:105-434) automated matches {Pyrococcus horikoshii [TaxId: 53953]}  ali model 3D-neighbors follow..  15  35..............................................................................................................ETLIMAAREWLLKDGWHEVFPPILVTG----------AVEGGATLFKLKYFDKYAYLSQSAQLYLEAAIFGLE-----KVWSLTPSFRAEKSRTRHLTEFWHLELEAA---MDLWDIMKVEEELVSYMFVYGYPKHIKAFYMKEDPNDPRK--------VLASDMLAPEGYGEIIGGSQREDDYILEEGMDPKDYEWYGFGLGVERLVAWVLKLDHIRWA.............. 318
9 -12.100d3a74a2 d.104.1.1 (A:146-492) Lysyl-tRNA synthetase (LysRS) {Geobacillus stearothermophilus [TaxId: 1422]}  ali model 3D-neighbors follow..  16  6...................................................................................KDIEQRYRQRYLDLIMNPESKKTFITRSLIIQSMRRYLDSHGYLEVETPMMHAVAGGAAARPFITHHNA--------LDMTLYMRIAIELHLKRLIVGGLE----KVYEIGRVFRNEGISTRHNPEFTMLELYEAYADFRIMKLTENLIAHIATEVLGTTKIQYGEHLVDLTPEWRRLHMVDAIKEYVGVDFWRQMSFEQKVEDKLIQPTFIEAHEMDEDFLEALGLGIGVDRLVMLLTNSPSIRDV.............. 339
10 -11.700d1jjcb5 d.104.1.1 (B:475-681) Phenyl-tRNA synthetase (PheRS) beta subunit, PheT, central domain {Thermus thermophilus [TaxId: 274]}  ali model 3D-neighbors follow..  15  2..............................................................................................LPAFFPAPDNRGVEAPYRKEQRLREVLSGLGFQEVYTYSFMDRRFRLDPPRLLLLNPLAPEKAAL-----RTHLFPGLVRVLKENLDLDRPERALLFEVGRVFREREETHLAGLLFGEGVGL--ERLSGYFLLKGYLEALFARL---GLAFRVEAQAFPFLHPGVSGRVLV--------------EGEEVGFLGALHPEIAQELELPP----VHLFELRLPLP........................... 204
11 -11.300d12asa_ d.104.1.1 (A:) Asparagine synthetase {Escherichia coli [TaxId: 562]}  ali model 3D-neighbors follow..  14  5.........................................................................................................KQRQISFVKSHFSRQLEELGLIEVQAPILSRVGDGTQDNLSGAEKAV-QVKVKALPDAQFEVVHSLAKWKRQTLGQHDFSAGEGLYTHMKALRPDELSPLHSVYVDQWERVMGDGERQFSTLKSTVEAIWAGI-SQELLSRYPDLDAKGRERAIAKDLGAVFLVGIGGKLSDGEDAFELSSMGILKHQLALTGDEDRLELEWHGGGIGQSRLTMLLLQLPHIGQVQAG........... 313
12 -10.000d1h4vb2 d.104.1.1 (B:2-325) Histidyl-tRNA synthetase (HisRS) {Thermus thermophilus [TaxId: 274]}  ali model 3D-neighbors follow..  15  20..............................................................................................................QRIVATARKVLEAAGALELVTPIFEETQVFEKGVGAATDIVRKEMF-TFQDRGGRSLTLRPEGTAAMVRAYLEHGQPVRLWMAGPMFRAERPQKGRYRQFHQYEALGSENPILDAEAVVLLYECLKELGLRRLKVKLSRPMLDFLEPALVRGLDYYVRTAFEVHHEEIGAQSALGGGGRYD-GLSELLG--GPRVPGVGFAFGVERVALAL....................... 315

FFAS is supported by the NIH grant R01-GM087218-01
1 2 5 9 6 3   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Friedberg I. and Godzik A Connecting the Protein Structure Universe by Using Sparse Recurring Fragments. Structure (Camb.) (2005) Aug;13(8):1213-24