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Query: [J] COG0016 Phenylalanyl-tRNA synthetase alpha subunit, from COG1018

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MREQLEALRDDAIKKIEQAQEKKVVQEIRVKYLGKKGPVTEVLRGMGKLSPEERPVIGQLANDVREAIGKAIESKMEALEQAEIHRKLQEETIDVTLPGRPVLKGGAHPLTATITEVEDLFIGLGFSVAEGPQIETDYYNFEALNLPKDHPARDMQDSFYFTDELLLRTQTSPVQARTMEKYKGKGPIKIICPGKVFRRDDDDATHSHQFMQIEGLYVDHGVRMSDLKGVLQAFAKSFFGEERSIRLRPSFFPFTEPSVEVDVSCGICHGDGCRVCKQTGWIEILGAGMVHPRVLEMSGFNPNEYSGFAFGMGVERLSMLKYGIDDIRHFYTNDRRFLAQFKRVLast
1 -136.000[J] COG0016 Phenylalanyl-tRNA synthetase alpha subunit  ali follow..  100  1MREQLEALRDDAIKKIEQAQEKKVVQEIRVKYLGKKGPVTEVLRGMGKLSPEERPVIGQLANDVREAIGKAIESKMEALEQAEIHRKLQEETIDVTLPGRPVLKGGAHPLTATITEVEDLFIGLGFSVAEGPQIETDYYNFEALNLPKDHPARDMQDSFYFTDELLLRTQTSPVQARTMEKYKGKGPIKIICPGKVFRRDDDDATHSHQFMQIEGLYVDHGVRMSDLKGVLQAFAKSFFGEERSIRLRPSFFPFTEPSVEVDVSCGICHGDGCRVCKQTGWIEILGAGMVHPRVLEMSGFNPNEYSGFAFGMGVERLSMLKYGIDDIRHFYTNDRRFLAQFKRV 344
2 -101.000[J] KOG2784 Phenylalanyl-tRNA synthetase, beta subunit  ali follow..  21  170MQFKWVSVDKGRVVRQATEVTDSTRKQLESLRIGSSDEKKELKKRKLISEVNIKALVVSKGTSFTTSLAKQEADLTPEMIASGSWKDMQFKKYNFDSLGVVPSSGHLHPLMKVRSEFRQIFFSMGFSEMTNRYVESSFWNFDALFQPQQHPARDAHDTFFVSDPAISTKFPEDYLERVKTVHSKFRPSKLFSIDRVFRNETLDATHLAEFHQVEGVIAEKNLSLAHLIGIFTEFFKKLGITNL--RFKPTYNPYTEPSMEIFAYH----------QGLTKWVEIGNSGMFRPEMLLPMGL-PADVNVAGYGLSLERPTMIKYGINNIRDLFGSKIDLNVVYNN. 545
3 -76.600[J] COG2024 Phenylalanyl-tRNA synthetase alpha subunit (archaeal type)  ali follow..  18  1MKFDPQKYRELAEKDFEAARSPNELYPRVGFSFGKEHPLFATIQRLREAYLSIGSEVVNPLIVEDVHVKKQFGREALAVLDRCFYLATLPKPNVGISAEKIRQIEAITKREVDSKPLQEIFHRYKKGEIDGDDLS--YLIAEVLDVDDITAVKILDEVFPISSTLTLRSHMTTGWFITLSHDKLPLPIKLFSIDRCFRREQEDATRLYTYFSASCVLVDEELSVDDGKAVAEALLRQFGFENFRFRKDEKRSKYYIPDTQTEVFAFHPKLVGSSTKYSDGWIEIATFGIYSPTALAEYDIP---YPVMNLGLGVERLAMILYGYDDVRKMVYPQIHGEIKLSD. 359
4 -68.200[J] KOG2783 Phenylalanyl-tRNA synthetase  ali follow..  24  2........................................................FPHRVSHLSKLFSRRFPNWKRKVQTDSWSN---VPEHIHSKIGRNLFQKEGHPICSLRQLLEQQFQKFEMNNVKESPIVSVETNFDSLGFPKTHVSRSKSDTYYMNNKTCLRTHTSAHQPEEFSAKEGFKKNGFLITADVYRRDEVDSSHYPIFHQMEGALVWNRNDTAKMKNDLKKVALSPSLKSMVDDETTALETHNDMQDIYSLFPFTKPSFQLEIDWKGKWLEILGCGVVQDRLLKGAGLN--NYIGWAFGIGLERLAMILYGIPDIRLFWSLDERFSKQFL.. 328
5 -14.000[J] KOG0554 Asparaginyl-tRNA synthetase (mitochondrial)  ali follow..  13  114IMGWVRTLRSQSSVTFIEINDGSCLSNLQC--VMTSDAEGYDQVESGSILTGAASQGTKQKVELKVEKIIVVGECDSSYPIQKKRVSREFLRTKAHLRPRTNTFGAVARVNTLAYATHKFFQESGFVWVASPIITAS---FCVTTLIPSSHENTDTSI-FFGKPAFLTVSGQLNGETYATALS-----DVYTFGPTFRAENSNTSHLAEFWMIEPELA---ADLDDDMACATAYLQYVIIRDYPKEIKAFYMRENDDGKTVAAMDMLVPRIG----------ELIGGSQREERLLDELKLNKESYWWYGFGLGFERLVQFVTGIDNIRDV.............. 555
6 -13.800[J] COG0017 Aspartyl/asparaginyl-tRNA synthetases  ali follow..  13  1MKTTIKQAKDHLNQDVT-LTNKRSSGKIAFLQLRDGTGFMQGVVVKSEVDEEVFKLAGTITEDNRSDLGYEMQVKSIEVISEAHDYPITPKNHGTEFLMDHRHLWLRSK-NEVIRATYEFFNKDGFTKVDPPILTAS----------APEGTSELFHTKYFDQDAFLSQSGQLYLEAAAMAHG-----KVFSFGPTFRAEKSKTRHLIEFWMIEGEMA---TNHAESLEIQEQYVTHVFITNYPTKIKPFYMQPNPENEET--------VLCADLIAPEGYGEIIGGSE---QRVKEHGLDEEAYSYYGFGLGLERTVAWISGVEHVRET.............. 418
7 -13.200[J] KOG0555 Asparaginyl-tRNA synthetase  ali follow..  13  146.........RDGYGFLQCVLNDKLCQSYDAVTLSTETSVQVYGIIKALPDGKSAPDGHELTVDYWEVIGKAPAGGIDNVLNESAGVDVMLDNRHLVIRGENASR--LRIRAAATRAMRDHFFAAGYTEVAPPTLVQT----------QVEGGSTLFGLDYYGEPAYLTQSSQLYLETCNAALG-----DVYCISQSYRAEKSRTRHLSEYQHVEAECA---ITFDQLMDRIEALVCDTVDRFVNPGYKAPARPFKRMPYKEAIEWLQKNDVRNEMGEKFVY-EIVGGSM---AAFEKGGLDSKNYYWYGYGLGLERFICWLTDTNHIRDV.............. 533
8 -13.100[J] COG2269 Truncated, possibly inactive, lysyl-tRNA synthetase (class II)  ali follow..  15  44..............................................................................................................ATLLRQIREFFAERNVLEVETPAMSHA--HLHTFKTEFVGPGYAKGSALHL----------MTSPEFHMKRLLAAGSGCIYQLGKAFRNEENGRYHNPEFTMLEWYRIGFDHHMDEMDALLQLVLRCGSAERMTYQLQLLFSIGIEPKIDFPASQAALAKINPADPRVADRFEVYFKGIIDYHLIAALEAGLPECAGV--ALGIDRLIMLALGEDHIDKV.............. 341
9 -12.600[J] KOG0556 Aspartyl-tRNA synthetase  ali follow..  10  139AVVNKDTISKQMVKWCGSISLESIVLVEGIVKKSPEIIKSATVQDA-EIHISSIYVISPIKKNLPFLVEDA-AEGDSKFVRVNLDTRLDNRVLDLRTPTNQ---AIFDIQAGICQAFREFLLSNSFNEIHTPKMSGA----------SSEGGSNVFKIQYFKTDGFLSQSPQLYKQMLIAADRE----RVFEIGPVFRAEDSNTYHMTEFTGLDLEMAFNE-HYHEVMEFIEKLFLYIFKT-IRFHFKDAVYP-----SSVRPFYTMPDPEDPRYSNSYDFFEIMSGAQLLVERMKALGVSPDV----GGGIGLERVVMFYLNLPNIRLA.............. 568
10 -12.600[J] KOG2472 Phenylalanyl-tRNA synthetase beta subunit  ali follow..  13  286..EPVEVTYDDGKSYIYPDLAVYDMEVPLSFITDSIGVSLKVEQVTSLLTRMQLQAEQAKSSDNQCAIKVHVPPSRSDVLHPCDVMEDVAIAYGFNIPTRKPASIKPLTLNELTDLLRIEIAMCVYTEVVTWLLCSHKENFAMLNREDVNSAVIVGNPRSADFEAMRRALMPGLLKTVGHNNKYPKPIKIFEISDVVMLDESKDVGASNRRHLAALYCGATSGFELIHGLVDRIMEVMAIPFLGYYVKLSQEPEFLPGRQASIIVR----------------HIGNFGIVHPEVLNNFDIP---DPCSYLELDIEAIL.......................... 598
11 -11.800[J] COG1190 Lysyl-tRNA synthetase (class II)  ali follow..  14  89.........QDVGGRIQLYVSRDDLPEGVYNEEFKKWDLGDILGARGKLFKTKTGELSIHCSELRLLTKALRPLPDKFHGLADQETRYRQRYLDLIANDESRHTFKVR--SQVMSGIRSFMVEKGFMEVETPMMQVIPGGASARPFVTHHNALDIDMYLRIAPELYLKR-------------------RVFEINRNFRNEGVSPRHNPEFTMMELYMAYADYKLIVLTEELFRTLTETILGSSVVQYGEQTFDFGKPFAKLTMKEAICKYRPETNVADLDFEETAESHLIQPTFIEAMFYDEDYITALGLGIGIDRMVMLFTNSHTIRDV.............. 495
12 -10.400[J] KOG1885 Lysyl-tRNA synthetase (class II)  ali follow..  14  146...DLRGEGVKLQVMANSRNYKSEEEFIHINNKLRRGDIIGVQGNPGKTKKGELSIIPYEITLLSPCLHML-----PHLHFGLKDKETRYRQRYLDLILNDFVRQKFIIRSKIITYIRSFLDELGFLEIETPMMNIIPGGAVAKPFITYHNE--------LDMNLYMRIAPELYHKMLVV--------RVYEIGRQFRNEGIDLTHNPEFTTCEFYMAYAD--YHDLMEITEKMVSGMVKHPDGPEGQAYDVDFTPPFRRINMVEELEKALGMKLPETNLVGEFLEVTCINPTFIEAMFIDENFCTALGWGMGIDRVAMFLTDSNNIKEV.............. 567
13 -10.200[E] COG2502 Asparagine synthetase A  ali follow..  12  8.........................................................................................................QQQEISFVKNTFTQNLIELGIIEVQGPILSQVGNGMQDNLSGIEKAVQVNVKCIPNAVFEVVHSLAKWKRHTLARFNFKEDEGLFVHMKALRPDEDLDPTHSVYVDQWEKVIPEGRRNFAYLKETVNSIYRAIRLTELAVERAPDYDDWTTESENGYKGLNGDILVWNDQLGKAFELSSMGIRVDESALRLQVGLTGDEDH--GGGIGQSRLAMLLLRKKHIGEVQSS........... 316
14 -9.550[J] COG0173 Aspartyl-tRNA synthetase  ali follow..  16  58..AAADSSRNEYVLSITGRVRNRPEGTTNDKM--ISGKIEILAKEIEVLNAAATPPF--QIDDENISENVRLTNRVIDLRRPVMQRNLRLR-------------------YQVAMGVRRYLDAQGFIDIETP----------MLTRSTPEGARDYLVPSRVHPGEFFALPQSPQLFKQLLMVAG----RYYQITKCFRDEDLRADRQPEFTQID--LETSFLNEDEIMDITEGMAKQVFKDEEADRYVAVHHPFTAPKEGHEDLMVSDPANCLARAYD-NGWEIGGGSIVQEKVFAALKISPEELDNLKFGFGLDRLVTLMTGAESIRDVIA............ 562
15 -9.140[J] COG0752 Glycyl-tRNA synthetase, alpha subunit  ali follow..  13  7.............................................................................................................FQEIILTLQQFWNDQDCMLMQAYDNEKGAGTM---------------------------------SPYTFLRAIGPEPWNAAYVEPSRRADGRYGENPNRLYQHHQFQVVMKPSPSNIQELYLESLEKLGILEHDIRFVEDNWENPSLGWEVWL----------------DGMEITQF------YFQQVGGLATGPVTAEVTYGLERLASYIQEVDSV................. 178

FFAS is supported by the NIH grant R01-GM087218-01
1 2 5 9 6 3   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Friedberg I. and Godzik A Connecting the Protein Structure Universe by Using Sparse Recurring Fragments. Structure (Camb.) (2005) Aug;13(8):1213-24