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Query: [J] COG0441 Threonyl-tRNA synthetase, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MPVITLPDGSQRHYDHAVSPMDVALDIGPGLAKACIAGRVNGELVDACDLIENDAQLSIITAKDEEGLEIIRHSCAHLLGHAIKQLWPHTKMAIGPVIDNGFYYDVDLDRTLTQEDVEALEKRMHELAEKNYDVIKKKVSWHEARETFANRGESYKVSILDENIAHDDKPGLYFHEEYVDMCRGPHVPNMRFCHHFKLMKTAGAYWRGDSNNKMLQRIYGTAWADKKALNAYLQRLEEAAKRDHRKIGKQLDLYHMQEEAPGMVFWHNDGWTIFRELEVFVRSKLKEYQYQEVKGPFMMDRVLWEKTGHWDNYKDAMFTTSSENREYCIKPMNCPGHVQIFNQGLKSYRDLPLRMAEFGSCHRNEPSGSLHGLMRVRGFTQDDAHIFCTEEQIRDEVNGCIRLVYDMYSTFGFEKIVVKLSTRPEKRIGSDEMWDRAEADLAVALEENNIPFEYQLGEGAFYGPKIEFTLYDCLDRAWQCGTVQLDFSLPSRLSASYVGEDNERKVPVMIHRAILGSMERFIGILTEEFAGFFPTWLAPVQVVIMNITDSQSEYVNELTQKLSNAGIRVKADLRNEKIGFKIREHTLRRVPYMLVCGDKEVESGKIAVRTRRGKDLGSMDVNEVIEKLQQEIRSRSLKQLEELast
1 -178.000[J] COG0441 Threonyl-tRNA synthetase  ali  100  1MPVITLPDGSQRHYDHAVSPMDVALDIGPGLAKACIAGRVNGELVDACDLIENDAQLSIITAKDEEGLEIIRHSCAHLLGHAIKQLWPHTKMAIGPVIDNGFYYDVDLDRTLTQEDVEALEKRMHELAEKNYDVIKKKVSWHEARETFANRGESYKVSILDENIAHDDKPGLYFHEEYVDMCRGPHVPNMRFCHHFKLMKTAGAYWRGDSNNKMLQRIYGTAWADKKALNAYLQRLEEAAKRDHRKIGKQLDLYHMQEEAPGMVFWHNDGWTIFRELEVFVRSKLKEYQYQEVKGPFMMDRVLWEKTGHWDNYKDAMFTTSSENREYCIKPMNCPGHVQIFNQGLKSYRDLPLRMAEFGSCHRNEPSGSLHGLMRVRGFTQDDAHIFCTEEQIRDEVNGCIRLVYDMYSTFGFEKIVVKLSTRPEKRIGSDEMWDRAEADLAVALEENNIPFEYQLGEGAFYGPKIEFTLYDCLDRAWQCGTVQLDFSLPSRLSASYVGEDNERKVPVMIHRAILGSMERFIGILTEEFAGFFPTWLAPVQVVIMNITDSQSEYVNELTQKLSNAGIRVKADLRNEKIGFKIREHTLRRVPYMLVCGDKEVESGKIAVRTRRGKDLGSMDVNEVIEKLQQEIRSRSLKQLEE 642
2 -168.000[J] KOG1637 Threonyl-tRNA synthetase  ali follow..  39  51PIKVTLPDGKQVDATSWTTPYEVARGISQGLADNTVISKVNGEVWDLDRVLEGNCTLQLLKFDDPEAQAVFWHSSAHIMGEAMERIYG-GHLCYGPPIENGFYYDMHLGEGISTNDYGAMEGLVKQIVKEKQNFERLEMKKSDLLEMFKY--NEFKVRILNEK-VTTDRTTVYKCGSLIDLCRGPHVRHTGKVKALKITKNSSTYWEGKADAETLQRVYGISFPDPKQLKEWEKLQEEAAKRDHRKIGREQELFFFHELSPGSCFFQPRGAHIYNTLMGFIKAEYRKRGFQEVISPNIYNAKLWMTSGHWQHYAENMFSFEAEKEKFALKPMNCPGHCLIFDNRNRSWRELPLRMADFGVLHRNELSGALTGLTRVRRFQQDDAHIFCAPEQIKSEMKGCLEFLKYVYTIFGFS-FQLVLSTRPDNYLGELEQWNDAEKALAESLNEFGMPWKENPGDGAFYGPKIDITIMDALKRAHQCATIQLDFQLPIRFNLSYIADDGEKKRPVIIHRAILGSVERMIAILTENFAGKWPFWLSPRQVMVVPVGPAYDQYAQSVRDQLHDAGFMSEADDAGDTMNKKIRNAQLAQFNFILVVGDKERSSNTVNVRTRDNKVHGEVSVAELITKLQKIRDEFIANEDS. 689
3 -86.200[J] KOG4163 Prolyl-tRNA synthetase  ali follow..  12  1....................MPVSEAFAKLCVNEKPPAESAVKSLVFKPKTPKSATPVPIVVVALQSTTTPSALIANATSSKDPRLARDDLVKQAFQSESARAFIL----GDLANATSNFHLLIDHELGTVDGDTILQLNDSTYMKKSDMMKFLNNFE------------DSQKVVDFSQEVSKETATEGKKQQKKQQPSKAGTAAAAAAAALEDAKLIGITVDKALDFPGYQQILTKGEMLDYYD-------------VSGCYILRPPSYAIWENIQKWFDDKIKAIGVQNAYFPMFVSSRVLKEKDHVEGFAPEVAWVSELEEPIAIRPTSETVMYPYYAKWVQSYRDLPLKLNQWNSVVRWEFKH-PQPFLRTREFLWQEGHTAHLTAKAEEEVLQILDFYAGVYEELLAVPVVKGRKTEKEK------------------------------FAGGDFTTTCEGYIPQTGRGIQGATSHHLGQNFSKMFNLSVENPLGSDHPKIFAYQNSWGLSTRVIGVMVMIHSDNIPPRVSQFQSVVIPVRKHIHETARSVESRLKKVGIRAFGDYNDNTPGWKFSQYELKGIPIRIELGPKDIEKNQVVVVRRNDSKKYVVSFDELEARIPEILEEMQGDLFKK 587
4 -70.700[J] KOG2324 Prolyl-tRNA synthetase  ali follow..  16  1.....................................................................................................................................................................................................................MLQHLRNRAS---IEVLGKAIRKYNVPESANQLL---IDMGFIQPSMPGIFQYLPLGLRVQNKICDLLHISMRSLGASAISLAHLSSKEIWEKSGRWQKTGSELFRLDRNDREMCLAPTHEEDVTRTMATIIDSQKQLPIRVYQIGRKFRDELRPR-GGLLRGREFMMKDLYTFDDKASAMKTYEDVLQAYHTFFKEVGLPFVMVKAATGNGNLSHEFHYRHPVGEDVIYTCPSCHYSTNSEMLDLSKTSSDISCPNCNDQLTSTTAIEVGHAFYLGKIYSSKFNATVEVKNKQEVLHMGCYGGVSRLIAAVAHVTKDAWPSSIAPWKVLVVPTSDNHIQSAETVYDATANVDNVLLEDRQNRAFGYKMRDAELIGYPFVIVVGSRFQEEGICEIIVRSSGERYKLDKDSLHQVLLGNF.......... 424
5 -31.700[J] COG0442 Prolyl-tRNA synthetase  ali follow..  21  4................................................................................................................................................................................................................................SQYLLSTQKETPADAEVISHQLMLRA----MIRKLASGLYTWLPTGVRVLKKVENIVREEMNNAGAIEVSMPVVQPADLWQESGRWEQYGPELLRFDRGERPFVLGPTHEEVITDLIRGEINSYKQLPLNFFQIQTKFRDEVRPR-FGVMRAREFLMKDAYSFTTQESLQETYDAMYTAYSKIFSRMDLNFRAVLADTGSIGGSASHEFQVLAESGEDDIVFSTGSDYAANIEFAEALAPTEEIKAEKLPQRGIEVGIFQLGTKYSEVMKATVQGEDGRNQVMTM---GCYGGVSRVVAAAIEQNHDDWPDAIAPFQVAILPMNFRVKELAEELYTTLRSHGIDVILDDRKERPGVMFADMELIGVPHNIVIGDRNLDSEEVEYKNRRVGEKQMIKTSEIVEFLLSQIKR........ 572
6 -27.500[J] COG0423 Glycyl-tRNA synthetase (class II)  ali follow..  18  1............................................................................................................................................................................................................................MTEVSKAAAFDRTQFEELMKKR----FSPSFQIY------SGLYDYGPPGSALQSNLVDIWRKHFIEESMLEVDCSMLTPHEVLKTSGHVDKFADWMCKDPATGEIFDIRNPATNGELLMFETQIFNNGKVPFASAMVGKAFRNEISPR-SGLLRVREFLMAEVEHFVDPKNKEHDRFDEVSRISLFLEKIGIDMNRVRFRQHMSNFEVEVNRKKFGPRFKRDAKAVEEAMISWPESEKVEKSAQLVAEGKIIVNVNGVEHTVESDL---VTIEKRKHTEHIRTYTPNVIEPSF--GLGRILYVLMEHA--SFPASIAPIKALIVPLSAEFAPFVKKLSAKLRNLGISNKIDDSNANIGRRYARNDELGTPFGLTVDFETLQNETITLRERDSTKQVRGSQDEVIAALVSMVEGKS...... 635
7 -21.200[J] KOG1936 Histidyl-tRNA synthetase  ali follow..  12  13...................................................................................................................................................................................................................ASLLSQLLRPPCASCTGAVRCQSQVAEAVLTSQLKAHQEKPNFIIKTP-KGTRDLSPQHMVVREKILDLVISCFKRHGAKGMDTPAFELKETL--TEKYGEDSGLMYDLKDQGELLSLRYDLTVPFARYLAMN----KVKKMKRYHVGKVWRRESPTIVQG--RYREFCQCDFDIAGQFDPMIPDA-ECLKIMCEILSGLQLGDFLIKVNDRESKFRAICSSIDKLKDVRHEMVVKKGLAPEVADRIGDYFGIADKISFDLSLAR--------LDYYTGVIYEAVLLQTPTQAGEEPLNVGSVAAGVERIFYIVEQR---------TETQVFVATPQKNFLQERLKLIAELWDSGIKAEMLKNNPKLLTQLHYCESTGIPLVVIIGEQELKEGVIKIRSVASREEVAIKRENFVAEIQKRLSES....... 506
8 -20.700[J] COG0124 Histidyl-tRNA synthetase  ali follow..  17  8.....................................................................................................................................................................................................................................................................GTQDILPGDVETWQWIEQKAYDLCRRYNYQEIRVPMFEHTELFLRGDTTDIVQKEMYTFEDRGRSLTLRPEGTASVTRAYSNKLYGQANQPTKLFYIGPMFRYERPQS-----RMRQFVQFGVEALGSADPAID--AEVLALVMRFYEELGLKNLKLVINSLDCKKDRDHELMGTAPEKVQSYLTALNIPFVVDATRGLDYYNHTAFEVMVDGEGFGAITTL--------RYN-GLVEEIGGPETPGI---GFALSIERAIMALEAQ--QAKPAHNQAIDCYVVTLGEAAKDKGVELVYQLRNAGISAEKDYLDRKMKGQLKAADRLHAKWTVILGEDELAVGKVNVKNMETGEQTDVALTDLVSHMKQQVEGGNES.... 428
9 -19.900[J] KOG2298 Glycyl-tRNA synthetase and related class II tRNA synthetase  ali follow..  15  14........................................................................................................................................................................RLAVRQQGDLVRKLKEDKAPQVDVDKAVAELK----------ARKRVLEAKELALQPKDDIVDRAKMEDTLKRR----YDQAFAIY------SGLYDFGPVGCALKNNIIQTWRQHFQEEQILEIDCTMLTPEPVLKTSGHVDKFADFMVKDVKNGECFYLRPETAQGIFLNFKR-EFNQGKLPFAAAQIGNSFRNEIS-PRSGLIRVREFTMAEIEHFVDPS---EKDHPKFQNVADLHLYLYSAKAQVSGQSARKMRLGDAVEQGVINNTVLGYFIGRIYLYLTKVG-AHYACDCWDAESKTSYGECYITEMEMLLNEKGINVKRFQKTLYVEEVVPNVIEPSF--GLGRIMYTVFEHT--SFPAVVAPFKCSVLPLNQEFMPFVKELSEALTRHGVSHKVDDSSGSIGRRYARTDEIGVAFGVTIDFDTVNKTTATLRDRDSMRQIRAEISELPSIVQDLANGNI...... 660
10 -18.200[J] KOG2509 Seryl-tRNA synthetase  ali follow..  12  1.....................................................................................................MVLDLDLFRVDKGGDPALIRETQEQLVKADSEWRRCRFRADNLNKLKNLCSKTIGEKMKKKEPVGDDESVPENVLSFDDLTADALANLKVSQIKKVRLLIDEAILKCDAERIKLEAERSNDEDVDNKVERIWGDCTVRKKYSHVDLVVMVDGFEGEKAGSRGYFLKGVLVFLEQALIQYALRTLGSRGYIPIYTPFFMRKEVMQEVAQLSQFDEELYKVDNSYDEKYLIATSEQPIAALHRDEWLRPEDLPIKYAGLSTCFRQEVGSDTRGIFRVHQFEKIEQFVYSSDNKSWEMFEEMITTAEEFYQSLGIPYHIVNIVSGSLNHAADLEAWFPGSGAFRELVSCSNCT----------------------------------DYQ-ARRLRIRYGQTKKMMDKVEFVHNATMCATTRTICAILENYQ-TVPEKLKEGLQELIPVKPAPIEQEPSKKQKKQHEGSKKKAAARDVTLENRLQNMEVTD..................................................... 513
11 -15.900[J] COG0172 Seryl-tRNA synthetase  ali follow..  15  134.............................................................................................................................................................................................................................................PFEPKAHWDLATALGIVDFERTGSRFAFYKGAGARLERALINFMMDLHHDKHYEEVLPPYLVNRTSMTGTGQLPKFEEDAF--KIREEDYFLIPTAEVPVTNLHRDEILSADQLPIAYTAYSMNFRSEAGSDTRGLIRQHQFNKVELVRFVAPEDSYDELEKLTGHAEKVLQLLKLPYRVMSMCTADLGFTADLEVWIPSANTYREISSCSNFE----------------------------------DFQ-ARRANIKFRREAKGKAEFVHTLNGSGLAVGRTVAAILENYQQEIPEVLRP....................................................................................................... 415
12 -13.100[R] COG2872 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain  ali follow..  16  45.......DTGKLVREEDGAEFEV---VYVGKFNGDISHEITPVDGNAALGLKAGDRVRGIIDWDRRYRHMRMHTATHVIANVIEKEA-GAQITGNQLGLDKSRVDFSLE-AFDRDKFAEYEKIANKVITENHPVNLYLVSRKEAEEKLSR-----LTTLAKGFSEEISEVRLVEIEGIIEACGGTHLKNTGEIKGIKIEKL-------QNKGKSNRRMYFTL.................................................................................................................................................................................................................................................................................................................................................................................................................................... 243
13 -11.300[E] COG3705 ATP phosphoribosyltransferase involved in histidine biosynthesis  ali follow..  11  8....................................................................................................................................................................................................................................................................EHIADVLPTNARQLESAREQLLALFRVHGYELVQPPLMEYAHSLLTHIDAGLSLKTILVTRLSGRQLGIRADITPQVARIDAHLLSA-NQGINRLCYAGPVLHAQSDGL-----NMREPLQAGAEMYGFADIRGD--IELIDLMLKSMKIADMGKVLLSLGHIGRALSDAAHLDAGQSATLLALMQDKTVEAQVKAWKLDGMWAKAFSLLPRLYGGREVLSDARGRLPDLSAVGGALGE-DAFPDCEIHIDLSELRVDNYHTGLLYAAYGGRYDGLGGIERQPAVLVDAEDAEAAHEAVEALREQGQCVVIDGIGHNVSEELAGRLKKTDGVWQVVKR............................................ 383

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Pawlowski K, Rychlewski L, Zhang B, Godzik A. Fold predictions for bacterial genomes. J Struct Biol. 2001 May-Jun;134(2-3):219-31. Review.