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Query: [V] COG1787 Predicted endonuclease distantly related to archaeal Holliday junction resolvase and Mrr-like restriction enzymes, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MEGKLMMEFTWQIGIIVVITVVLLVGWVVYRLKEKKRYDVAKITIRDIDRMDGHEFEDYLFVLLAGLGYNETYQTKKSRDFGADLLFNDSSGARTVVQAKCLSDALGVKAIQEVFTAKVYYQAEKAIVITSTETISDPCRRLASAAEVKLIEREALQEIIALFKREQMKQAQDVIEAPPEKIKTTPEDSYVYPEQDQQVIRSGEFYYKKPSSFFKRSGLast
1 -94.400[V] COG1787 Predicted endonuclease distantly related to archaeal Holliday junction resolvase and Mrr-like restriction enzymes  ali  100  1MEGKLMMEFTWQIGIIVVITVVLLVGWVVYRLKEKKRYDVAKITIRDIDRMDGHEFEDYLFVLLAGLGYNETYQTKKSRDFGADLLFNDSSGARTVVQAKCLSDALGVKAIQEVFTAKVYYQAEKAIVITSTETISDPCRRLASAAEVKLIEREALQEIIALFKREQMKQAQDVIEAPPEKIKTTPEDSYVYPEQDQQVIRSGEFYYKKPSSFFKRSG 218
2 -52.900[V] COG1715 Restriction endonuclease  ali follow..  15  143...........................RLEQALNEIRESVAEELLENLLQVSPARFEVIVLDVLHRLGYGDLQRVGGTGDGGIDGIISLDGLEKVYVQAKRWKGTVGSAEVRGFYGALPEQKVKRGVFITTSG-FTAHARDYANKEGLVLVDGDRLVHLMIDNDIGVSSRLLKLPKLDMDYFE................................... 304
3 -42.900[S] COG4127 Uncharacterized conserved protein  ali follow..  12  173.............................SNPLRDMEMIAFEGIKDRINRLDWDEMQNLVAGVLRSMGYK-TQVSPAGADREKDIIASPDENPRIIVEVKHRREQMSSQQIRSFIGGR--HKDDRGLYVSTGG-FSKDARYEADRSTLTLWTLDDLVRALVENYEQVDIETKLLVPLKKTYLPA.................................. 329
4 -16.500[L] COG1591 Holliday junction resolvase - archaeal type  ali follow..  11  4................................................KKRKGSAVERNIVSRLRDKGFAVVRAPASGSDPIPDIIAL-KNGVIILIEMKSRKDIEGKIYVRRGSLFLGVKKPGVLKFIPFEKLRRTETGNYVADSEIEGLDLEDLVRLVEAKISRTLDN................................................ 141
5 -12.800[L] COG1637 Predicted nuclease of the RecB family  ali follow..  21  111........................................................EDHLQELLAEHGYTLIRREYPTAIGPVDILCRNSDGETVAVEIKRRGGIDGVEQLTRYLELLNRDELLKPVGVFAAQEIKPQAKTLAEDRGIKCVT.................................................................. 213
6 -11.700[V] COG2810 Predicted type IV restriction endonuclease  ali follow..  13  1.......................MMIEIIKDIQRKLRNHREVYISNEEAV------QHIILPILSSLGWEEVRPEEKTSEGRADYALIKDGKVVAFIEAKNLSVNPAKAVQQ-----LAKYCFDMGVIVSNGRVW................................................................................... 110
7 -10.800[L] COG0551 Zn-finger domain associated with topoisomerase type I  ali follow..  11...........................................................................................GRNMAIRTASTGVFLGCTGYALPPKERCKTTINLIPEAELLNVLDESSETKALMDRKRDSYVIDAHRKIHICGNNPNCDGYLIEEGSFKIKGYDGPVVECDKCGADMHLKLGRFG-----KYMGCTN 140
8 -10.300[S] COG4748 Uncharacterized conserved protein  ali follow..  11  8............................LLLDVKKLGERVSALKDSIATEEATK--TSLIMPFFQLLGYDVFNPLEIKKGEKVDYAILNNNNPIILIEAKSIKSDLKNHDSQ-----LFRYFGTTTAILTNGNEY................................................................................... 120
9 -10.100[R] COG4889 Predicted helicase  ali follow..  14  5.........................................TDAVSALRTLPGLAFEKLMVNFIKSD-WVDWPYNGGTMDTGIDLVAYNKDDDAYAIQCKFYLPTLAKGQLDSFFEASGRRSFSNRLVISTTDKWSSNAEKMLENQTIPTPGSELTINLQLKEPYSPRPHQQTAIEKAIEGFQTHDRGKLIMACGT...................... 205
10 -9.210[A] COG5239 mRNA deadenylase, exonuclease subunit and related nucleases  ali follow..  134........................LKWHKRSKVLVHELKKYRPDVVSLQEVDYNELNFW-QENFHKLGFDVIFKRHEGKTHGLLVAWNNKKFQLDNDWMLDYDNILNIALIISLYFKGITDSSSRGIIVANTHLFWHP-----FGVFERLRQSYLVLQKIQEIKACSKYNGWHSLLMGDFNTEPEEP............................... 302
11 -9.180[S] COG5474 Uncharacterized conserved protein  ali follow..  13  1.......................MILRQLNRIDMSSFDFPKYQANQEVGNTGEAFFEHFVT---KELGC-IYRKVHREHDFGIDGYIDVVSGRSVAVQIKCGDSYISKVTSGGIKYLGDNKHLN--ILVDCTKGYVNATNPSSKSWWIEIPFENQLGT............................................................ 152

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Li W, Jaroszewski L, Godzik A. Tolerating some redundancy significantly speeds up clustering of large protein databases. Bioinformatics. 2002 Jan;18(1):77-82.