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Query: [R] COG2872 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MTEVLYFLDCYLREFEAIVEKVTDDKYVVLDRTAFYPESGGQPSDTGKLVREEDGAEFEVVYVGKFNGDISHEITPVDGNAALGLKAGDRVRGIIDWDRRYRHMRMHTATHVIANVIEKEAGAQITGNQLGLDKSRVDFSLEAFDRDKFAEYEKIANKVITENHPVNLYLVSRKEAEEKLSRLTTLAKGFSEEISEVRLVEIEGITIEACGGTHLKNTGEIKGIKIEKLQNKGKSNRRMYFTLLDLast
1 -122.000[R] COG2872 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain  ali  100  1MTEVLYFLDCYLREFEAIVEKVTDDKYVVLDRTAFYPESGGQPSDTGKLVREEDGAEFEVVYVGKFNGDISHEITPVDGNAALGLKAGDRVRGIIDWDRRYRHMRMHTATHVIANVIEKEAGAQITGNQLGLDKSRVDFSLEAFDRDKFAEYEKIANKVITENHPVNLYLVSRKEAEEKLSRLTTLAKGFSEEISEVRLVEIEGITIEACGGTHLKNTGEIKGIKIEKLQNKGKSNRRMYFTLLD 245
2 -80.100[R] KOG2105 Predicted metal-dependent hydrolase, contains AlaS domain  ali follow..  24  16VSTKRPPPAMDDLDFTTTVVSCLSGFQVVLEDTVLFPEGGGQPDDRGTI------NDISVLRVTRRGEQADHFTQ-------TPLDPGSQVLVRVDWERRFDHMQQHSGQHLITAVADHLFKLKTTSWELGRFRSAIELDTPSMTAEQVAAIEQSVNEKIRDRLPVNVRELSLDDPEVEQVSGRGLPDDH---AGPIRVVNIEGVDSNMCCGTHVSNLSDLQVIKILGTEKGKKNRTNLIFLSGN 260
3 -59.800[J] COG0013 Alanyl-tRNA synthetase  ali follow..  28  479...............DEIVDEVSGKAQLVFDVTPFYAEMGGQVADHGVIKDAEGQVVANVLDVQHAPHGQNLHSVETLSP----LKVGESYTLEIDKERRAAVVKNHTATHLLHAALHNIVGNHAAGSLNEVEFLRFDFTHAQVTKEELAEIERQVNEVIWQSLKVETVETDIATAKEM-GAMALFGEKYGK---NVRVVKIGDYSIELCGGTHTQTTSEIGLFKIVKEEGIGSGVRRIIAVTGQ 703
4 -54.600[J] KOG0188 Alanyl-tRNA synthetase  ali follow..  26  521...................ITSGQKAGIVLDKTNFYAESGGQIYDQGALVKVNDEANEFLVDRVYNRGGYILHIGVVEGT----LKVGDELELHIDVERRWLTMKNHSATHALNHCLLQVLGKDTKGSLVVPEKLRFDFNSAAMTIEQVSKTEQLTKEMVYKNVPIYAKESKLALAKKIRGLRSVFDEVYPD---PVRVISFGQTSVEFCGGTHLRRSGHIMDFVISSEEAIAKGIRRIVALTGP 758
5 -13.300[J] KOG1637 Threonyl-tRNA synthetase  ali follow..  13  26IEERNVFWEKCKAEYEAELAAKKREPIKVT-----LPDGKQVDATSWETTPYE----ARGISQGLADNTVISKVNGEVWDLDRVLEGNCTLQLLKFDDPEAQAVFWHSSAHIMGEAMERIYGGHLCYGPPIENGFYYDMHLEGISTNDYGAMEGLVKQIVKEKQNFERLEMKKSDLLEMFKYNEFKVRILNETTDRTTVYKCGSL-IDLCRGPHVRHTGKVKALKITKNKADAETLQRVYGIS.. 270
6 -13.100[J] COG0441 Threonyl-tRNA synthetase  ali follow..  16  8............................................DGSQRHYDHAVSPMDVIGPGLAKACIAGRVNGELVDACDLIENDAQLSIITAKDEEGLEIIRHSCAHLLGHAIKQLWHTKMAIGPVIDNGFYYDVDLDTLTQEDVEALEKRMHELAEKNYDVIKKKVSWHEARETFANKVSILDENIAHDDKPGLYFHEEY-VDMCRGPHVPNMRFCHHFKLMKTDSNNKMLQRIYGTA.. 222
7 -5.600[K] COG1329 Transcriptional regulators, similar to M. xanthus CarD  ali follow..  13  1...........MATITPQKKSTGARHGFKTGEYIVYPAHGGQIVSIDEQEVAGHKLELFVIDFQKDKMRLKVPVAKATSIGMRKLSEEDYVERALKWSRRAQEYDAKINSG-ISEVVRDLYRADNQPEQSYSERQLYEAALDRMARESETEAVRLIEVNLNKGPK................................................................................ 177
8 -5.310[G] COG0149 Triosephosphate isomerase  ali follow..  48................QELVRLTEGTNLRVAQNCYFEDEGAFTGEISPFALADLGVSYVIIGHSERREYFHETDEDINKKAHAIFKHGMTPIICCTLDQREAGQTDTWVRGQIRAALAGLTEEQVIKSVIAYEPIWAIGTGKSSTSADANETCAVIRAEVADAVS-----------QKAADAVRIQYGGSVKPENIADYLAESDIDGALVGGASLEPASFLALLEAVK................. 251
9 -5.090[J] KOG2364 Predicted pseudouridylate synthase  ali follow..  258...............................SDSRFVTSGREDIDVRML-GTGRPFVVELRNCRTTAPVRGIKYLETLKTVQEAINVQKDVKV-----VSLTRVPRDVSEKLCVGEEDK-----------RKQYCAYCYSILPISDSQFTAAQSKIPLKIVQKTPVRVMKRRALLDRER-------------WIYSMNFLKLDDVRLETQAGTYIKEHGDFGRTELLDVEHGEVDILELDVE... 449
10 -4.630[O] COG5661 Predicted secreted Zn-dependent protease  ali follow..  15  102................................................................................................WDTLLQDIRRHEESHIIARSHASEMEREIRSLRSRADCASLRADIDKVTSRVMEAHDEAQQYF...................................................................................... 165

FFAS is supported by the NIH grant R01-GM087218-01
1 3 3 7 4 3   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Pawlowski K, Rychlewski L, Zhang B, Godzik A. Fold predictions for bacterial genomes. J Struct Biol. 2001 May-Jun;134(2-3):219-31. Review.