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Query: [J] KOG0188 Alanyl-tRNA synthetase, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MKLLTAKEVRNAYLDFFKEQKHIYVHSSSTIPLDDPTLLFANAGMNQFKPIFLGTADPNSEMSKWVRVANTQKCIRAGGKHNDLDDVGKDVYHHTFFEMLGNWSFGDYFKKEICSWAWEFLTQRLALPKDRLYVTYFGGDAASGLEPDLECKQMWLDLGLKPEHILPGSMKDNFWEMGETGPCGPCSELHFDRIGGRSVPELVNMDDPDVLEIWNLVFIQYNRESDGSLKQLPKKHIDCGMGFERLVSVIQNKRSNYDTDLFVPLFDAIQAGTGAPPYQGRVGADDVDGIDMAYRVLADHARTITIALADGGTPDNTGRGYVLRRILRRAVRYATEKLNAKPGFFATLVNTVVDLLGDAFPEVKKDPQHIIDIINEEELQFLKTLTRGRNLLNRTIEKLGNQTTIPGDVAWRLYDTYGFPVDLTQLMAEEKSLKIDMDGYEAAKHNSYVLSQGKGASKIEEINLDVHAISQLQEQGVPPTNDTFKYKYEAVSDERDSAYNYGVCNSKIVALRFENQFVNEITSGQKAGIVLDKTNFYAESGGQIYDQGALVKVNDEANEFLVDRVYNRGGYILHIGVVEGTLKVGDELELHIDVERRWLTMKNHSATHALNHCLLQVLGKDTEQKGSLVVPEKLRFDFNSKAAMTIEQVSKTEQLTKEMVYKNVPIYAKESKLALAKKIRGLRSVFDEVYPDPVRVISFGVPVDELEQNPDSEAGEQTSVEFCGGTHLRRSGHIMDFVISSEEAIAKGIRRIVALTGPEALKALKKSEAFEQEIVRLKATIDNDKSGKDSKSHVKEIVELTEQISHATIPYVKKDEMRNLLKGLKKTLDDKERALRAAVSVTVVERAKTLCEANPNATVLVEQLEAFNNTKALDAALKQVRSQLPDAAAMFLSVDADSKKIFCLSSVPKSAVEKGLKANEWVQHVSATLGGKGGGKPESAQASGTNYEKVDEIVQLASKFAQSKLSLast
1 -239.000[J] KOG0188 Alanyl-tRNA synthetase  ali  100  1MKLLTAKEVRNAYLDFFKEQKHIYVHSSSTIPLDDPTLLFANAGMNQFKPIFLGTADPNSEMSKWVRVANTQKCIRAGGKHNDLDDVGKDVYHHTFFEMLGNWSFGDYFKKEICSWAWEFLTQRLALPKDRLYVTYFGGDAASGLEPDLECKQMWLDLGLKPEHILPGSMKDNFWEMGETGPCGPCSELHFDRIGGRSVPELVNMDDPDVLEIWNLVFIQYNRESDGSLKQLPKKHIDCGMGFERLVSVIQNKRSNYDTDLFVPLFDAIQAGTGAPPYQGRVGADDVDGIDMAYRVLADHARTITIALADGGTPDNTGRGYVLRRILRRAVRYATEKLNAKPGFFATLVNTVVDLLGDAFPEVKKDPQHIIDIINEEELQFLKTLTRGRNLLNRTIEKLGNQTTIPGDVAWRLYDTYGFPVDLTQLMAEEKSLKIDMDGYEAAKHNSYVLSQGKGASKIEEINLDVHAISQLQEQGVPPTNDTFKYKYEAVSDERDSAYNYGVCNSKIVALRFENQFVNEITSGQKAGIVLDKTNFYAESGGQIYDQGALVKVNDEANEFLVDRVYNRGGYILHIGVVEGTLKVGDELELHIDVERRWLTMKNHSATHALNHCLLQVLGKDTEQKGSLVVPEKLRFDFNSKAAMTIEQVSKTEQLTKEMVYKNVPIYAKESKLALAKKIRGLRSVFDEVYPDPVRVISFGVPVDELEQNPDSEAGEQTSVEFCGGTHLRRSGHIMDFVISSEEAIAKGIRRIVALTGPEALKALKKSEAFEQEIVRLKATIDNDKSGKDSKSHVKEIVELTEQISHATIPYVKKDEMRNLLKGLKKTLDDKERALRAAVSVTVVERAKTLCEANPNATVLVEQLEAFNNTKALDAALKQVRSQLPDAAAMFLSVDADSKKIFCLSSVPKSAVEKGLKANEWVQHVSATLGGKGGGKPESAQASGTNYEKVDEIVQLASKFAQSKLS 966
2 -196.000[J] COG0013 Alanyl-tRNA synthetase  ali follow..  33  1MKTMTSAEVRQMFLDFFKSKGHTVEPSQSLVPVNDPTLLWINSGVATLKKYFDGSVVPE-----NPRLTNAQKAIRT----NDIENVGKTARHHTMFEMLGNFSIGDYFRKEAIAFAWELLTEWFEFPAEKLYITYYPA--------DKDTYNRWVEVGVDPTHLVPI--EDNFWEIG-AGPSGPDTEIFFDRGEVYDPEHAEDIENDRYIEIWNIVLSQFNADPRSEYPELPQKNIDTGMGLERMVCIIQGGKTNFDTDLFLPIIREIEKLSGKTY--------SPDSENMSFKVIADHIRSLSFAIGDGALPGNEGRGYVLRRLLRRAVMHGKK-LGIQGKFLASLVPTVGKIMQSYYPEVLEKEDFIMQIIDREEETFNRTIDAGQKLIDELLLNLKGKDRLEGADIFRLYDTYGFPVELTEELAEDEGFKIDHEGFKVAMKAQQERARAAVVKGG--------------------SMGAQNETLSSIEVESEFLYEDKTTQGKLLVSIQDDEIVDE--VSGKAQLVFDVTPFYAEMGGQVADHGVIKDAEGQVVANVLDVQHAPHGQNLHSVETLSPLKVGESYTLEIDKERRAAVVKNHTATHLLHAALHNIVGNHALQAGSLNEVEFLRFDFTHFAQVTKEELAEIERQVNEVIWQSLKVETVETDIATAKEM-GAMALFGEKYGKNVRVVKIG----------------DYSIELCGGTHTQTTSEIGLFKIVKEEGIGSGVRRIIAVTGQKAYEAFKDAENTLNEVATMVKAPQTSQVLAKVTSLQDELKTAQKEN----------------------------DALAGKLAASQSDEIFKNVQTAGSLNFIASEVT-VPDANGLRNLADIWKQKELSDVLVLVAK--IGEKVSLLVASKSS----DVKAGNLVKELAPFVDGRGGGKPDMAMAGGSKAAGIPELLAAVAEKLA.... 872
3 -54.600[R] COG2872 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain  ali follow..  26  20........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................EKVTDDKYVVLDRTAFYPESGGQPSDTGKLVREEDGAEFEVVYVGKFNGDISHEITPVDGNLKAGDRVRGIIDWDRRYRHMRMHTATHVIANVIEKEAGAQI--TGNQLGLDKSRVDFSL-EAFDRDKFAEYEKIANKVITENHPVNLYLVSRKEAEEKLSRLTTLAKGFSEEVRLVEIE----------------GITIEACGGTHLKNTGEIKGIKIEKLQNKGKSNRRMYFTLLD................................................................................................................................................................................................................ 245
4 -53.600[J] COG0752 Glycyl-tRNA synthetase, alpha subunit  ali follow..  17  3.KKLTFQEIILTLQQFWNDQDCMLMQAYDNEK---------GAGTMSPY-TFLRAIGPEP-----WNAAYVEPSRRP----AD----GRYGENPNRLYQHHQFQVVMPSPSNIQELYLESLEKL--------------------------------GINPLEHDIR----VEDNWENPSTGSAGLGWEVWLD------------------MEITQFTYFQQVGG-----LATGPVTAEVTYGLERLASYIQEVDSVYDIEWADGVKYGEIFIQPEYEHSKYSFEIEEGLVHPAYDYVLKCSHTFNLLDARGAVSVTERAGYIAR--IRNLARVVAKT--------------VAERKRLGYPLLDEETRAKLLAEDAE............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 305
5 -52.500[R] KOG2105 Predicted metal-dependent hydrolase, contains AlaS domain  ali follow..  16  2...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ELAHVEHYAELLKKVSTKRPPPAMDDLDFTTTVVSCCPAELQTEGSEVLSGFQVVLEDTVLFPEGGGQPDDRGTIND------ISVLRVTRRGEQADH---FTQTPLDPGSQVLVRVDWERRFDHMQQHSGQHLITAVADHLFKLKTTSWE--LGRFRSAIEL-DTPSMTAEQVAAIEQSVNEKIRDRLPVNVRELSLDDPEVEQVSGRGLPDDHAGPIRVVNIE----------------GVDSNMCCGTHVSNLSDLQVIKILGTEKGKKNRTNLIFLSGNRVLKWMERSHGTEKALTALLKCGAEDHVEAV-------------------------KKLQNSTKILQKNNLNLLRDLAVHIAHSLRNSPDWG---------VVILHRKEGDSEFMNIIANEIGSEETLLFLTVGDEKGGGLFL---------LAGPPASVETLGPRVAEVLEGKGAGKKGRFQGKATKMSRRMEAQALLQDYISTQSA 426
6 -7.600[J] COG0441 Threonyl-tRNA synthetase  ali follow..  17  47.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ACDLIENDAQLSIITAKDEEGLEIIRHSCAHLLGHAIKQLWPHTKMAIGPVID-NGFYYDVDLDRTLTQEDVEALEKRMHELAEKNYDVIKKKVSWHEARE---TFANRGESY--KVSILDENIAHDDKPGLYFHEE-----VDMCRGPHVPNMRFCHHFKLMKTAGANKMLQRIYGTAWADKKALNAYLQRLEEAAKR.............................................................................................................................................................................................. 242
7 -7.550[L] COG0587 DNA polymerase III, alpha subunit  ali follow..  13  14.........EPRFVHLRVHSDYSMIDGLPALAITDFTNLC---GLVKFKPI-IGADFYVQSEILGDELAHLTVLARNNEGYQNLTLLISEAYQRGYRDWLIKHKEGKFLLRGNQVQVDQCLAFYQEHFPDCYYLELIRTGRPDEENYLHAAVALATERGL---------------------PVVATNDVRFIDESDFDAHEIR-VDPKRPKNYSPQQFMRDEEQMCELFADIPEALINSVEIAKRCNVTIEMSTEDFLVEKKQGLEERLEFLFPDPEVRLQKRPEYDERLDIELKVINQMGFPGYFLIVDNGVPVGPGRGSGAGSL----VAYALKITDIDPLEFDLLFERFLNPERVSMPDFMEKRDLVIEHVAEMRDAVSQIITFGTMAAKAVIRDVGRSKLIPLDPGMTLEKAFAAEPQLAEIYEADEEVRIDMARKLEGVTRNAGKHAGGVVIAPTKITDFAPLYCDAEGNNPVTQFDKNDVEYAGLVKFDFLGLRTLTIINWALEMINARRAKTGLEPIDIASIPLEDKKSFD-QRSETTAVFQLESRGMKDLIKRLKPDCFEDMIALVALFRPGPLQSGMVDNFIDRKHGREAISPDIEWQHSLKPVLEPTYGIILYQE-SLGGADMLR---AMGKKNPAEMAKQRSVFEDGAKNQGIDGELAIKIFDLVEKFAG----FNKSHSAAYALVSYQTLAAVMTADMDNTDKVVGLVDECWRMGLK-NSGLYHFHVNDDGEIVYGIGAIKGV-GEGPIEAILEARKEGGYFKELF----DLCARVDTKKLNKRILEKLIMSGAFDRLGPHRAALMSSLGDALKAADQHAKAEAIGQVD............................................................................................................................. 933
8 -7.370[L] KOG0220 Mismatch repair ATPase MSH4 (MutS family)  ali follow..  10  87....NKRAYAENTVASNFTFGASSSSARDT---NYPQTLKTPLSTGNPQRSGYKSWTPQVGYSASSSSAISAHVAVVEGRGLARGEIG------ASIDLNPQIILSQFADNTTYA---KVITKLKILSPLEIIMSNTACAVGNSTKNETKGLEYIEQLCIAEFSTVLMEVQSKYYCLAAVAALLKYVEFIQNSVYAPKSLKICFQGSEQTAMI-ELLINNQDYRNNHTLFGV--NYTKTPGGSRRLRSNI--LEPLVDIETINMRLDCVQELLQ--------DEELFFGLQSVISRFLDTEQLLSVLVQIPEQDTVNAAESKITNLLKHTLELVDPLKIAMKNCNTPLLRAYYGSLED--KRFGIILEKIKTVINDDADIARRTYTEIVDDIAGMISQLGEKYSLPLRTSLS--SVRGFFIQMTTDCIALPSDQLPSE--------KISKVKNSYSFTSADLIKMNERCQESLREIYHMTYMIVCKLLSEIYEH-----------------------IHCLYKLSDTVSMLDMLLSFAH----------ACTLSDYVRPEFTDTLAIKQGWHPILEKISAEKPIANNTYVTEGSNFLIITGPNMSSTYLKQIALCQIMA----QIGSYVPAEYSSFDIETNSSTFMKEMKEIAYILHNANDKSLILIDEL-AVCEYLLSLKAFTLFATHFLELCHIDALYPNVENMHFEVQHVKNTSRNKEAILYTYKLSKG------LTEEKNYGLKAAEVSSLPP----SIVLDAKEITTQITR--QILQNQRSTPEMERQRAVYHLATRLVQTARNSQLDPDSLRIYLSNLKKKYKEDFPRTEQVPEKT............................................................................................................................ 934
9 -6.940[J] KOG0402 60S ribosomal protein L37  ali follow..  13  1................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................MAKRTKKVGITGKYGVRYGSSLR---------RQVKKLEIQQHARYDCSFCGKKTVKRGA-AGIWTCSCKKTVAGGAYTVSTAAAATVRSTIRRLREMVEA................................................................................................................................................................................................. 92
10 -6.900[D] KOG1042 Germ-line stem cell division protein Hiwi/Piwi; negative developmental regulator  ali follow..  13  218.RLLKIMNLQQIGRNYYNPNDPIDIPSTSILQYENSIMLCTDVSHKVLRDFMFNFYHQTEEHKFQEQVSKELIGLVVLTKYNNVDDIDWDQNPKSTFKK-SEVSFLEYYRKQ-----YNQEITDLKQP------VLVSQPKRRRGPGGTLPGELCYLTGLTDKMRNDFNVMKDLAVHTRLTPEQRQREV-----GRLIDYIHKNDNVQRELRDWGLSFDSNLLSFSGRI--LQTEKIHQGGK----TFDYNPQFADWSKET-----APLISVKPLDNWLLIYTRRNYEAANSLIQNLFKVTPAMGMQMRKAIMIEVDDRTEAYLRVLQQKVTADTQI----------VVCLLSSNRKDKYDAIKKYLCTDCPTPSQ--------------VVARTLGKQQTVMAIATKIALQMNCKMGWRVDIPLKLVMIVGIDCSIAGFVASINEGRWFSRCIFQDRGQELVDGLKVCLQAALRAWNSCNEYMPSRIIVYRDGVGDGQLKTLVNYEVPQFLDCLKSIGRGYNPRLTVIVVKKTRFFAQSGGRLQNPGTVIDVE-------VTRPEWYDFFIVSQAVRSGSVSIYDNSGLKPDHIQRLT----YKLCHIYYNWPGVIVGQSIHREPNLSLSNRLYY.......................................................................................................................................................................................................................................................................................................................................... 860

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Pawlowski K, Rychlewski L, Zhang B, Godzik A. Fold predictions for bacterial genomes. J Struct Biol. 2001 May-Jun;134(2-3):219-31. Review.