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Query: [G] KOG2161 Glucosidase I, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MVSDMLGGNKRWILFGLLSFLLNCVLVSCSVEDIEKAANDSFLWGPYRPNLYVGIRPKIPDSLMTGLMWSNVDDYARFSKMRHSAEHGDDIGAFGWKHYDVRRGGQQVIDDFLMGIKLETDFVKLPEGNWALRVHGIPLPGAPTDLTTSLFFYAYVEGEGKVGTKVNHANHVYMEGKTPDLGKFRIQTFNRLGEHPVSPASVDLESMVMDKDFFAGFNVKKEGAWRTSELILYLLDTKMKVISDKEGYESLKDLPPAYSTLTLPNLPSEEGLQFIQKVFKGEFMFDIVFNYASSKKISEEMISQAIDKNLQEFEEKFQATFPLKAPYDTEKAHQIFAHTAFSNLFGNVGFFTGDSIVSKNPIELDDEDYEFMQGFESAAGKLAEGTAFHDIERSLFTIVPSRPHFPRGFYWDEGFHLLPVGLWDNDFSLEILKSWFSLVNEDGWVGREQILGEEARSKVPDEFQTQYPDIANPPTLILALKGYIERLQEQQGKLNNRFSGEGEDYSLDDLEYLRSVSISNPEKSVQFLRDLFPLLLRHYEWFRETQKGDFETWERECFSQVEGYRWRGRTYQHCLASGLDDYPRAQPPSTAELHVDLLSWMTSFTRSLHFVAEFLGETEEAEKLAGYENAMLRNLEDNHWDEEVQAYCDSSVDEYDDPINVCHKGYVTLLPMMLGLLPADSGRLTSLLKLIRDENELWSPYGIRSLSMNDVYFGTGENYWRGPIWINMNYLILSSLYQNYINTPGPNQNLARSIYEELRTNVVNNVFENWRQTGIFWEQYDPTTGKGQRTKDFTGWTSLVVNIMSENYLast
1 -229.000[G] KOG2161 Glucosidase I  ali  100  1MVSDMLGGNKRWILFGLLSFLLNCVLVSCSVEDIEKAANDSFLWGPYRPNLYVGIRPKIPDSLMTGLMWSNVDDYARFSKMRHSAEHGDDIGAFGWKHYDVRRGGQQVIDDFLMGIKLETDFVKLPEGNWALRVHGIPLPGAPTDLTTSLFFYAYVEGEGKVGTKVNHANHVYMEGKTPDLGKFRIQTFNRLGEHPVSPASVDLESMVMDKDFFAGFNVKKEGAWRTSELILYLLDTKMKVISDKEGYESLKDLPPAYSTLTLPNLPSEEGLQFIQKVFKGEFMFDIVFNYASSKKISEEMISQAIDKNLQEFEEKFQATFPLKAPYDTEKAHQIFAHTAFSNLFGNVGFFTGDSIVSKNPIELDDEDYEFMQGFESAAGKLAEGTAFHDIERSLFTIVPSRPHFPRGFYWDEGFHLLPVGLWDNDFSLEILKSWFSLVNEDGWVGREQILGEEARSKVPDEFQTQYPDIANPPTLILALKGYIERLQEQQGKLNNRFSGEGEDYSLDDLEYLRSVSISNPEKSVQFLRDLFPLLLRHYEWFRETQKGDFETWERECFSQVEGYRWRGRTYQHCLASGLDDYPRAQPPSTAELHVDLLSWMTSFTRSLHFVAEFLGETEEAEKLAGYENAMLRNLEDNHWDEEVQAYCDSSVDEYDDPINVCHKGYVTLLPMMLGLLPADSGRLTSLLKLIRDENELWSPYGIRSLSMNDVYFGTGENYWRGPIWINMNYLILSSLYQNYINTPGPNQNLARSIYEELRTNVVNNVFENWRQTGIFWEQYDPTTGKGQRTKDFTGWTSLVVNIMSENY 808
2 -69.400[G] KOG0602 Neutral trehalase  ali follow..  157.............................................................................................................................................................................................................................................................................QELTIAKSFGRHQIFLDEARINENPVNRLSRLINTQFWNSLTRRVDLNNVGEIAKDTKIDTPGAKNPRIYVPYDCPEQYEFYVQEYLPKKITAEYVKSVNDTPGLLALAMEEHFNPSTGEKTLIGYPYAVPGGR-FNELYGWDSYMMALGLLEANKDVARGMVEHFIFEINHYGKIL--------------NANRSYYLCRSQPPFLTEMALVVFKKLGGRSNPDAVDLLKRAFQASIKEYKTVWTASPRLDPESRYHPNGLGIPPETESDHFDTVLLPYASK--HGVTLDEFKQLYNDGKIKEPKLDEFFLHDRGEGVCAYLATIDLNSLLYKYEIDIADFIKEFCDDTTSAMWKEMAKIRQEKITKYMWDDESGFFFDYNTKIKHRTSYE---SATTFWALWAGLATKEQ--AQKMVEKALPKLEMLGGLAACTERSRGPSISRPIRQWDYPGWAPHQILAWEGLRSYGY----------LTVTNRLAYRWLFMMTKAFVDYNGVVEKYDVTRDFKGAATEGFGWVNASYILGLKYM 720
3 -69.400[G] COG1626 Neutral trehalase  ali follow..  157.............................................................................................................................................................................................................................................................................QELTIAKSFGRHQIFLDEARINENPVNRLSRLINTQFWNSLTRRVDLNNVGEIAKDTKIDTPGAKNPRIYVPYDCPEQYEFYVQEYLPKKITAEYVKSVNDTPGLLALAMEEHFNPSTGEKTLIGYPYAVPGGR-FNELYGWDSYMMALGLLEANKDVARGMVEHFIFEINHYGKIL--------------NANRSYYLCRSQPPFLTEMALVVFKKLGGRSNPDAVDLLKRAFQASIKEYKTVWTASPRLDPESRYHPNGLGIPPETESDHFDTVLLPYASK--HGVTLDEFKQLYNDGKIKEPKLDEFFLHDRGEGVCAYLATIDLNSLLYKYEIDIADFIKEFCDDTTSAMWKEMAKIRQEKITKYMWDDESGFFFDYNTKIKHRTSYE---SATTFWALWAGLATKEQ--AQKMVEKALPKLEMLGGLAACTERSRGPSISRPIRQWDYPGWAPHQILAWEGLRSYGY----------LTVTNRLAYRWLFMMTKAFVDYNGVVEKYDVTRDFKGAATEGFGWVNASYILGLKYM 720
4 -31.600[G] COG3408 Glycogen debranching enzyme  ali follow..  11  13..................................TYEEGTKREWGGYASSTVIGAGTRTYHGLLVAAPENFPGRLLLLSSLDEEISIDKEVYKLATHKYPDNIS--------PEGFNYLSEFIRSPFPLWVYQAG---------DFTLKKKVFMVHGSNTTYVLYDIISRKEGALLKIFPLVSSRDFNLTARSGYLSFYQKAGPAGVELASSNGFTFSLSSNLQYHPDPIWYFNLEYDTEKKRGLNFQEDIFNPGYFESKLEPGAS--------RFFVAASTKDISSLTLEQVDKLYVREANRQNLLILDSKLIESFALKLLRATDSFVVKNHATGENTVIAG-------------------------------------------------------------YHWYSDWDSMISLLLLIPYRFEEARSALNNFARYC-RRGLIPNTF-----------FGGDPIYNTVDASLWFIHALDRYFAYTQDFL-----------------------------------FLSDVWDTVSSIIDNYCA------------GTDFAIGMDSDYLIWQGPQLTWMDKVGEWAVTPRAGKACEVNALWYNALKTASYMGTLLG--EDISSYETLAAGVASNFENTFWNPESNCLFDIHQDEAGNQVKDPAIRPNQIFAVSLPYTMLSPEKEKAIVDRVEK--DLLTPFGLKTLSSDHPLYKGDTAYHNGTVWPWLLGAYVKAYLKVNNSSKS-----SLEEMRVLLEGFDAHLEVA--GIGTISEVFDGDYPHAPGGSIAQAWSAEILRAYVEDV 654
5 -25.200[G] KOG2119 Predicted bile acid beta-glucosidase  ali follow..  143......................................EKSTYHALY-PRSWTVYDGEPDPELRIVSRQVSP--------IPHNYEESS-VSVFNFTVTN---------GAEPAIVTLLFTWENSVGGASGLTGQHFNSTMKTANGHPPVSYAIAAKETEDVRVSSCPCFIVSGTTPNQITAG-EIKKNASFDKLTSNACSPSKPGTSIGAAIAAKVKVPPGCDRTVTFSLSWDCPEARFDEKTYHRRYTRF------------GSLGNAAVAMAHDALLNFPEWETQIEEWQAPVLADTTLPEWYRVTLFNELYYFNSTMWTDGLPPKQSLDSIGRRKISLGLSTIDKNDQDQNNVALDILGRIDAVCSQIHAPLTSNAALGNTMIQNTTENIGQFLYLEGVQYLMYNTYDVHFYSFALLMLFPKIELSIQRDFAAARKVLGAVPHDIGLNDPWFELNAYNLFNTDRWKDLNSKFVLQVYRDVVATGDLN-----------------------------------FAKAVWPSVYTAIAYLDQF-DKDGDGMIEN---------------EGFPDQTYDAWSCSGVSAY------CGGLWVAALQAGSALAREIGDNGAAVYFNAKYEKARSVYEKLWNGSY---FNYDNSRSGSSSSILADQMAGQWYARACGLKP-KEEWIKKALETVYDMRVRDGTRGAVNGMLPDGRVDTSTMV-SREVWAGTTYSVAACMIQEGLADKG-------RTASGIYEAAWSDRGLGCAFQTPEAWTTNDEYRSLCYMRPLAIWG--IQWAHTMPK 846
6 -18.500[G] COG4354 Predicted bile acid beta-glucosidase  ali follow..  9....................................................................................................GIPLG------------IGTGKINFYPDLTIGEITILNNWSNPLRKVRGFHLLTFLDKKPIFLQTNPGKNVETPPQDIETFVEFPVIRYSTPLAEIEVYSILRKNDVKNSSLPVIKFR------IKGKGRFAISFPNIVGSKRAGRANESYKGKLNGVVMKNEKALNSDPAYGEIFLGCIGCKVITNYAYYKPAKVGMTEDITYFYNLEEYDETYVIKPYAREEIGGIVYKDVDEEETFILSWYFNGRPYHYPYGHYYENFFKDSIDVAEYALKLEPDLGIEEKVEWLKDALVNSLYILTSNTWL-RFAVYEDPFVTKLMNTIGSMTLVISADNYFMNYVNYGETPHDVGEESIEDPIYGASYPYWWTDLG--PTLVLMLYRDYVFTSNRE-----------------------------------ILEKNYNKIKEIIDWLIR-KDMDNDCIPDS---------------KGGYDNSYDGTHMYGASSY------IASMFLSALTAFIKMSEILDV-KIDDKYYRFLECGKKTFNSLWNGKY---FILWKKNDEENTSCLNSQLLGQFWCDILGLPP-DHDKINTALRSIYELNFKASKYCLTNAVREDGSVDSSTAQ-LRSCWPRVSFAVAAHMILRGMVKEG-------EVAKREWETIKEL--NPFDQSSRIDAIDGKYVGLMSYIGSTSVWLLKLAL...... 644
7 -17.200[G] COG3387 Glucoamylase and related glycosyl hydrolases  ali follow..  65...........................................................................................................................................................................................................................................................................................................................................................................................................IIASPSTDSPDYYYQWDSALTIMTILDRFFEGDKGLEPIIVKYMDEMVRLQKVPNPSGDFYAGGLGEPKFNVDGTSSPALRAIAFIKYMNYLFENGKEV-------------------------------HEVTVWIEAVLADLDYTANHWTEASFDL-------------------------WEEIKDVHYFTLAVQKRAMQD---------TAFAKRIGAPDQAALYQRTIEPIDLKLGE-FWDPGMGVIKGYKGRVDRSGLDCSTLLASLYSNEF----MHILPTLLKLQETMTRDYPVNQGWKQAMGRYPEDVYDGVSK--IGNPWFICTSSAAEIIYKAIAYYDNKGLSVIRKNMHTYADNFLKAVAEFQHPNGSMSEQFSRDDGHQKGARDLT-WSYSSLLNAIYRR 443
8 -13.600[S] COG3538 Uncharacterized conserved protein  ali follow..  11  70.........................................................................................................................................................................................................................................................................................................................................................................................................................MWDSTAQMKPYLFLEDEEIRKIIAGLVKRQFRY---------------------------CIDPYANAFNEEANEKGHQTDHTQMNPWIWERKYEIDCLCYPIQLAYLLYRETGSTDQFNDFHRGVELILDLWTVEQDHAQSPYLFERDTWRKEDTLTHAGKGSPVATGMDDACQYGYLIPS------NMFAVVVLSYLEDLYNNLFHNEPATRAKQLKEAIQSGIADHALNSKGETIYAYEVDGLGQFSIMDDANIPSLLAAYLGFCTKDDPIYLATRRTILSQEN-------PYYYQGNAAAGIGSSH--NYIWHIALALQGLTALD-----------------QDSKKEMLDLLVATDAGTHLMHEGFDVNDPYQY-TREWFSWANMMFCELLLDY 430
9 -13.400[G] COG3537 Putative alpha-1,2-mannosidase  ali follow..  10.KRSLALALTLAIGCGQAAWAQPATDLLAKVDPFVGVDGGGVTGGNTVPGA-FGFVSLSPDTTNADTNGYDSRSPIMGFSYTHVSGTG--TPTVGPLRVNHLHFGKTDERASPGYYTVGLG--NTDAERIKVELTATRRVG-PASAESHLIFDVSSVIAMRGRGQRVRLAKVELIDDHTLAGEVTVEGGWNPTPYTLYFHAVTDRPAKAFGAWKAGQGWMETKPGPGRSEGGVQVKSAANRLGLMIEYDTEREFSNRLGAYLTFDTTANRQV---QMKLAVSFISADKARANLDEEAPGWDFDATRRTTEAQWSDALSKI---RVEGGREEQQRIFYSALYRSHTMPHDLTGENVWWTS----------------------------------------DEPHYEDFYTLWDTFRTLHPLTIIQPQRQRDMIRSLLDTYKHTGWMPDSRIAGANGMTQGGSNGDILIADAVSKKLGGFDVNLAYEAILKNGEVDSDKPFMQG------------------------------RVLKDYLKLGYVPFTET-------------------RSASRTLEYAYNDF------------------------AIAVVAKSLGKTEDAKRYLARSGNWKN-----LWDDAIGCVRPRYPNGE-----------------------------------------WVENYSCTYDYPDRSGPWWDAVFYEGNSL-QYSSFVVAGLMANGPDGFVKWLDHLFDGHYSQSNEPDLLAPYLYIHAGRMAKHYRLSRTGLPGNDDAGAMSSWYVWNAMGLY 680
10 -9.420[I] KOG0497 Oxidosqualene-lanosterol cyclase and related proteins  ali follow..  1..........................................MW-LFTTNNFAGRQ-----------IW-SPEELAEVEEARLNFANNKSRFKAS-RIEDAEKITYEDAKTALRRGVLYYAACQANDGHWPSEVSGSMFLDAP----FVICLYITGHLEKIFTLEHVKELLRYMYNTQNEDGGWGLDVESHSVMFCTVLNYICLRVEPDHDGQKSACARARKWILDHGGATYAPMVAKAWLSVLGVYDWSGCKPLPPEIWMLPSFSPINIRDLLMGMSY-LQLREELYPQPYSKIIWSKARNRCAKEDLLYPKSFGQDLFWEGVHNKFVRQRALRTTMELVHYHDETTHYITGACVAKPFHMLACWVEDPDGDYFKKHLARVPDFIWIAEDGLKFQLMGMQ--------SWNAALSLQVMLAANMDDEIRSTLI-----------GYDFLKQSQISENPQGDHLKMFRDITK----GWTFQDREQGLPISDGTAESIECCIHFHRMPSEFIGEKMDV---------------EKLYDAVNFLIYLQSDNG------------GMPVWEPAPGKKWLEWLSPVEHVENTVVEQEYLECTGSVIAGLVCFKKEFPDHRPKEIEKLIKKGLKYIEDL------QMPDGSWYGNWGVCFTYGTLFAVRGLAA-----AGKTFGNSEAIRRAVQFILNTQNAEGGWGESALSCPNKKYIPSKG----TGQA------MMVLLIGGQMERDP----------SPVHRAAKVLINSQLDIG----DFPQQERRGIYMNHYPTYRNMFSLWALALY 752
11 -9.060[S] COG3101 Uncharacterized protein conserved in bacteria  ali follow..  10  18.................................FADDFNTRLIKGDDEP-IYLPADAEVPYN----IVFAHGFYASAIHEISHWCKARREQVDFGWYCPDGRDAQTQSQFEDVEVKPQALDWLFCVAAGYPFNVSCDNLEGDFEPDRVVFQRRVHAQVMDYLTNGIPERPARFIKALQNYYHTPELT............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 171

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Ye Y, Godzik A. Comparative analysis of protein domain organization. Genome Res. 2004 Mar;14(3):343-53.