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Query: [L] KOG2379 Endonuclease MUS81, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MDDERRVLCPENRGLAAYVLQKKQEYAEKPKGLSENLERTFVKGYRSVCDAKDPINTLKDLSQIKGFGKWMVKLMKGYFDTAVESSEQEDLPDNRAGKKANGKKRYIPQRNSVGYALLITLHRRTTNGKEFMRKQELIDAADANGLSHAPVGYMLTVEGREVANECILRSGLPDSVDILSVDEMDPTPQAKKTPNQNPTCSFTMREELPYVDPRCRAQSAIPSDILEKFTPFGYSKEQVVAAFREVSDGSGDKDPSTLWLSVMCHLRQAEVYNSCPDSRNSKKDSSGPFKSQIRQVDLEGSRAKKFRSCNDGSTLNPCSSGSSHAVKACSSSVRRLPVGDCIWIARHKYLETEYVLDFIAERKNVDDMRSSIRDNRYRDQKLRLQRSGFKKLIYILEGDPNHSDAAESIKTACFTTEILEGFDVLRTHGLGETLRKYGYLTKSIYQYYKLRVNDNDQSKGAASCPSFDSFVKRCQDLDKMTISDVFAIQLMQVPQVTEEIAIAVLDMYPTLLSLASAYSHLYQESSCDWFRSTLSSSGDRVSDHDQLFKGRPSPLFCFCYRKIQKLQRIQGRVLDHDVTDHRGMWVERLIRLHEFDMCLNGARIRIRDTFLLLLKFLDFVSRKIRLLKFLDFVSQKIRTNETNTCLTSQRTEQDQKNDDCCLast
1 -184.000[L] KOG2379 Endonuclease MUS81  ali  100  1MDDERRVLCPENRGLAAYVLQKKQEYAEKPKGLSENLERTFVKGYRSVCDAKDPINTLKDLSQIKGFGKWMVKLMKGYFDTAVESSEQEDLPDNRAGKKANGKKRYIPQRNSVGYALLITLHRRTTNGKEFMRKQELIDAADANGLSHAPVGYMLTVEGREVANECILRSGLPDSVDILSVDEMDPTPQAKKTPNQNPTCSFTMREELPYVDPRCRAQSAIPSDILEKFTPFGYSKEQVVAAFREVSDGSGDKDPSTLWLSVMCHLRQAEVYNSCPDSRNSKKDSSGPFKSQIRQVDLEGSRAKKFRSCNDGSTLNPCSSGSSHAVKACSSSVRRLPVGDCIWIARHKYLETEYVLDFIAERKNVDDMRSSIRDNRYRDQKLRLQRSGFKKLIYILEGDPNHSDAAESIKTACFTTEILEGFDVLRTHGLGETLRKYGYLTKSIYQYYKLRVNDNDQSKGAASCPSFDSFVKRCQDLDKMTISDVFAIQLMQVPQVTEEIAIAVLDMYPTLLSLASAYSHLYQESSCDWFRSTLSSSGDRVSDHDQLFKGRPSPLFCFCYRKIQKLQRIQGRVLDHDVTDHRGMWVERLIRLHEFDMCLNGARIRIRDTFLLLLKFLDFVSRKIRLLKFLDFVSQKIRTNETNTCLTSQRTEQDQKNDDCC 661
2 -93.200[L] COG1948 ERCC4-type nuclease  ali follow..  18  1........MELSSNLKDLYIEWLQELVDGLTPKQEQLKIAYEKAKRNLQNAEGSFYYPTDLKKVKGIGNTIIKRLDTKLRNYCKIHHISPVEPEEKGTKKRKTRKYIPKKRSGGYAILLSLLELN-AIPRGVSKEQIIEVAGKYSDHCMEFYGAWSSIAALKKHSLVLEEGRPKRYSLTEEGVELTKSLKTASEFTANLTDLRGEYGKEEEPCDINNTSFMLDITFQDLSTPQRLQNNVFKNDRLNSQTNISSHKLEEVSDDQTVPDSALKAKSTIKRRRYNGVSYELWCSGDFEVFPIIDHREI------KSQSDREFFSRAFERKGMKSEIRQLALGDIIWVAKNKNTGLQCVLNTIVERKRLDDLALSIRDNRFMEQKNRLEKSGCEHKYYLIEETMSGGNMNEALKTALWVILVYYKFSMIRTCNSDETVEKIHALHTVISHHYSQKDREFERKGGIECCHNLECFQELMGKGDLKTVGELTIHVLMLVKGISLEKAVAIQEIFPTLNKILMAYKTCSSEEEAKLLMFNVL--------------------------GDAPGAKKITKSLSEKIYDAFGK............................................................................. 631
3 -22.400[L] KOG0442 Structure-specific endonuclease ERCC1-XPF, catalytic component XPF/ERCC4  ali follow..  13  728......................................................................................................................................................................................................................................................................................................................VDMREFMSSLPNVLHQKGMKIIPVTLEVGDYILSPS-----------ICVERKSIQDLFQSFTSGRLFHQVEMMSRY-YRIPVLLIEFSQSDDVTPYNIISKLSLLVLHPRLRLLWSRSLHATAEIFTTLKSNQDEPDETRAIRVGVPSEE---------GIIENDIRAENYNTSAVEFLRRLPGVSDANYRSIMEKCKSLAELASL---------PVETLAELMGGHKVAKSLREFLDAKYPTLL......................................................................................................... 956
4 -13.000[L] KOG2841 Structure-specific endonuclease ERCC1-XPF, ERCC1 component  ali follow..  45......................................................................................................................................................................................................................................................................................................................VNPRQKGNPLLPHVRNVPWEY---TDIVPDFV--------------GICSLFLSLKYH--HLHPEYIYSRISKLGKSYNLRILLILVDVEN----HQASIQELVKTSIVNQYTLILAWSSEEAARYLETYKAYENMS-----------------------PALIMEKPSTDYLSQVQSFLTSIRGINKSDSLSLLSKFGSLERALVA---------SRDELEQLE------------WGPTKVNRFLEAVQQPFMSHSTIKRPEAINLKQT................................................................................ 252
5 -13.000[L] COG5241 Nucleotide excision repair endonuclease NEF1, RAD10 subunit  ali follow..  45......................................................................................................................................................................................................................................................................................................................VNPRQKGNPLLPHVRNVPWEY---TDIVPDFV--------------GICSLFLSLKYH--HLHPEYIYSRISKLGKSYNLRILLILVDVEN----HQASIQELVKTSIVNQYTLILAWSSEEAARYLETYKAYENMS-----------------------PALIMEKPSTDYLSQVQSFLTSIRGINKSDSLSLLSKFGSLERALVA---------SRDELEQLE------------WGPTKVNRFLEAVQQPFMSHSTIKRPEAINLKQT................................................................................ 252
6 -8.900[J] KOG3070 Predicted RNA-binding protein containing PIN domain and invovled in translation or RNA processing  ali follow..  22  332......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................SEEDGEDTSRALSPL-GPSHPYSLRYHPFDQCV-GIKVNI---YLFIVCSME-AKREARL-K-CDCLPMKRKLSEA--CV-EPALKQSRKTERLC 449
7 -7.950[K] KOG0487 Transcription factor Abd-B, contains HOX domain  ali follow..  16  185..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................SRKKRCPY-TKYQTLELEKEFNMYLTRDR-RHE-----VARLLNLSERQVKI-----FQNRRMK----------KKMNKEQGKE... 250
8 -7.460[K] KOG0848 Transcription factor Caudal, contains HOX domain  ali follow..  16  186..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................KDKYRVVY-TDHQRLELEKEFSRYITIRR-KAE-----LAATLGLSERQVKI-----FQNRRAKERKIN----KKKLQQQQQQQP.. 257
9 -7.390[K] KOG0844 Transcription factor EVX1, contains HOX domain  ali follow..  22  181.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................DQMR-RYRTAFIARLEF-NYVSRRCELAAALNLPETTIKV------FQNRRMKDKRQR.... 242
10 -7.080[R] KOG0493 Transcription factor Engrailed, contains HOX domain  ali follow..  16  449.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................DKTNDEKRPRTAFSSE----------QLALKREFNRYLTERR-RQQ-----LSSELGLNEAQIKI-----FQNKRAKIKKSTG-LALQLMAQGLYNHT.. 532

FFAS is supported by the NIH grant R01-GM087218-01
1 2 8 5 9 5   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Zmasek CM, Zhang Q, Ye Y, Godzik A. Surprising complexity of the ancestral apoptosis network. Genome Biol. 2007 Oct 24;8(10):R226 [Epub ahead of print]