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Query: [S] KOG2640 Thioredoxin, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MVPAAGRRPPRVMRLLGWWQVLLWVLGLPVRGVEVAEESGRLWSEELLHDPMGRDRAAEEANAVLGLDTQGDHMVMLSVIPGEAEDKVSSEPSGVTCGAGGAEDSRCNVRESLFSLDGAGAHFPDREEEYYTEPEVAESDAAPTEDSNNTESLKSPKVNCEERNITGLENFTLKILNMSQDLMDFLNPNGSDCTLVLFYTPWCRFSASLAPHFNSLPRAFPALHFLALDASQHSSLSTRFGTVAVPNILLFQGAKPMARFNHTDRTLETLKIFIFNQTGIEAKKNVVVTQADQIGPLPSTLIKSVDWLLVFSLFFLISFIMYATIRTESIRWLIPGQEQEHVELast
1 -129.000[S] KOG2640 Thioredoxin  ali  100  1MVPAAGRRPPRVMRLLGWWQVLLWVLGLPVRGVEVAEESGRLWSEELLHDPMGRDRAAEEANAVLGLDTQGDHMVMLSVIPGEAEDKVSSEPSGVTCGAGGAEDSRCNVRESLFSLDGAGAHFPDREEEYYTEPEVAESDAAPTEDSNNTESLKSPKVNCEERNITGLENFTLKILNMSQDLMDFLNPNGSDCTLVLFYTPWCRFSASLAPHFNSLPRAFPALHFLALDASQHSSLSTRFGTVAVPNILLFQGAKPMARFNHTDRTLETLKIFIFNQTGIEAKKNVVVTQADQIGPLPSTLIKSVDWLLVFSLFFLISFIMYATIRTESIRWLIPGQEQEHVE 343
2 -48.700[O] KOG0191 Thioredoxin/protein disulfide isomerase  ali follow..  13  1............MRLPLLSFVIFALFALVFASGVVEL---------QSLNELENTIASKKGALIEFYATWCGHCKSLAPVYEELGALFEDH------NDVLIGKIDADTHSDVADKYHITGFPTLIWFPPDGSEPVQYSNARDVDSLTQ--------VSEKTGIKKRKIVLPSNVVELDSLNFDKVVMDDKKDVLVEFYADWCGYCKRLAPTYETLGKVFKNVEIVKINADVFADIGRLHEVASFPTIKFFPKDKDKPELYEGDRSLESLIEYINKKSGTQRSPDGTLLSTASNAAKEVVLEKVKQLALEDSSRWTKYYKKVFEKILNDENWVHKEAK..... 325
3 -43.800[O] KOG0907 Thioredoxin  ali follow..  61............................SPGKVGTPPANDEKVQKIHSGEEFDVALKNAKSKVAEFATSKSDQSNKIYPFMVELSRTCNDVVF------LLVMGDESDKTRELCRREKIEKVPHFSFYKSMEKIHEEEGIEPDQLMGDVL------------YYGDNHSAVVQLHGRPDVEKLIDENRTGGKLIVLDVGLKHCGPCVKVYPTVLKLSRSMSEVVFARMNGDENDEFLKDMNVIEVPTFLFIRDGEIRGRYVGS--GKGELIGEILRYSGVRVT............................................................ 301
4 -43.200[OC] COG0526 Thiol-disulfide isomerase and thioredoxins  ali follow..  13  222................................ADFIGVSSIPLLDELNQMTFGKYQQSGLP-LGIIFYNSTESRDELYDVFQPLAKKYQDTLR--------FAFLDAVRYGAVAKQMNVESDWPAFVIANLKSMLKYPFPTTELTAKAMTKFVGDFVDGKLQPKIKSQPESQEDLVVLVADNFDDIVMDETKDVLVEFYAPWCGHCKNLAPTYEKLAEEYSDVVVAKIDATEND---ISVSISGFPTIMFFKANDKNPVRYEGDRTLEDLSAFIDKHASFEPIKKEKESVPAPDLEDQVAVEDE....................................... 487
5 -41.900[O] KOG0910 Thioredoxin-like protein  ali follow..  18  78.............................................................................................................................................................................GIKEIGESEFSSTVLESAQPVLVEFVATWCGPCKLIYPAMEALSQEYGDLTIVKIDHDANPKLIAEFKVYGLPHFILFKDGKEVPGSREGAITKAKLKEYIDGLLNSISVA........................................................... 190
6 -41.000[O] KOG0190 Protein disulfide isomerase (prolyl 4-hydroxylase beta subunit)  ali follow..  12  2.......................................................ASSSTSISLLLFVSFILLLVNSRAENASSGSDLDEELAFL------AAEESKEQSHGGGSYHEEEHDHQHRDFENYDDLEQGGGEFHHGDHGYEEEPLP--------------PVDEKDVAVLTKDNFTEFV-GNNSFAMVEFYAPWCGACQALTPEYAAAATELKGAALAKIDATEEGDLAQKYEIQGFPTVFLFVDGEM-RKTYEGERTKDGIVTWLKKKASPSIHNITTKEEAE------RVLSAEPKLVFGFLNSLVGSESEELAAASRL.............. 248
7 -39.300[R] KOG4277 Uncharacterized conserved protein, contains thioredoxin domain  ali follow..  16  24........................................................................................................................................................................TNPPTAVLDLSDKFLDV---KDEGMWFVEFYAPWCAHCKRLHPVWDQVGHTLSDIRVGKLDCTRFPAVANKLSIQGYPTILFFRNGHVID--YRGGREKEALVSFAKRCAA------PIIEVINENQIEKVKLSARSQPSYVFFGTSSGPLFD---------AFNEAASSKFSV. 181
8 -34.900[O] KOG0908 Thioredoxin-like protein  ali follow..  18  2...........................................................................................................................................................................SVRVINDESHFQAELAQAGIQLVVVDFTASWCGPCKRIAPIFETFPTKYPKAIFLKVDVDKCQDTAAGQGVSAMPTFIFYRNRTKIDRVQGADV--NGLEAKIQEHIGTSGGEEGGEDYGQGLMELNTFISKQE...................................... 133
9 -33.800[AD] KOG3414 Component of the U4/U6.U5 snRNP/mitosis protein DIM1  ali follow..  2.........................................................................................................................................................................SYLLPHLHSGWAVDQSILAEEERLVVIRFGHDWDETCMQMDEVLASVAETIKNAVIYLVDITEVPDFNTMYELYDPSTVMFFFRNKHIMIDL-GTGNNNKINWALKDKQEF............................................................... 112
10 -29.700[S] COG4243 Predicted membrane protein  ali follow..  184............................................................................................................................................AGINKPDVTSSNIPPGQVAPFVPKTNPNPEFGWEINSTSGEAEIALAQHLVKVGAKEYVAYWCPHCHDQKLLFGKEAYQIISVECAEDSPKGQPELCRAAKIQGFPTWIIN------GQTYSGVQNLSELAKITGYTGPSNFKY........................................................... 325
11 -29.600[O] COG3118 Thioredoxin domain-containing protein  ali follow..  17  2.........................................................................................................................................................................SDTPYIFDVTGANFEQLVIENSF-VLVDFWADWCAPCKALMPLLAQIAESYQGLLLAKVNCDVEQDIVMRFGIRSLPTVVLFKDGQPVDGF-AGAQPESQIRALLEPHVKAPALPDEDPLEV.................................................... 125
12 -28.100[O] KOG2603 Oligosaccharyltransferase, gamma subunit  ali follow..  45.........................................................................................................................................................................NAKKPLLRFNGPKFREYVKSAPRSMIVMLTARQCQICRHAHDEFAIVANSYNKLFFAMVDFDDGSEVFQLLRLNTAPVFMHFPAKGKPKGIHRVGFAADSIAKFVAERTDITIRIFRPPNYSGTVAMITLVALRNNLEFLYNKNLWGAIAVFFCFAMISGQMWNHIRG...... 238
13 -26.300[OC] KOG1672 ATP binding protein  ali follow..  17  67.............................................................................................................................................................................EYREVSEGDFLGEVTRSEK-VICHFYHKEFYRCKIMDKHLKTLAPRHVDTKFIKVDAENAPFFVTKLAIKTLPCVVLFSKGVAMDRL--GFQDLGTKDDFTTNKLENVLLKKVREFLLKECKSLTGMLSKKKK..................................... 197
14 -24.700[S] KOG3425 Uncharacterized conserved protein  ali follow..  14  2....................................................................................................................................................................................ENLIKLYENQRSPIYIYFYGSWCPDCVAAEETIMSAFRNHADCMILVVDVGSRESRKPPYSVEGIPTLIRWKGVERLDGDQ---LKSSLLELFFEETDPKKSN............................................................ 119
15 -23.800[T] KOG3170 Conserved phosducin-like protein  ali follow..  10  22....................................................................................................TKESIKESEEKAEEEQHILQQSVVTTYEDMTLEELEDHEDEFNEEDEHAIEMYRWQRLAEGKAIKLKNKFGEVLEISGKYYVQEVTKASEGLWVILHLCKRGIPLCALINQHLSGLARKFPDVKFIKANST---TCIPNYPDRNLPMVFVYLEGDIKAQL-GMNLTRDELGWKLSESRAVKTDLEENPKKPIEGVLLSSV........................................... 224
16 -20.700[O] COG2143 Thioredoxin-related protein  ali follow..  13  71........................................................................................................................................................................................KSISPNDKYMLLVFGRNGCSYCERFKKDLKELRDYIEHFSAYYVNISYSKELAQIYAVQSTPTIVLSKTGKTIYELYMPSTQFLAVLEFIGD................................................................... 189
17 -18.100[R] KOG2501 Thioredoxin, nucleoredoxin and related proteins  ali follow..  10  1...............................................................................................................................................................................MSTNVMQVLVSKLVG-KTIGLYFGAHWCPPFRSFTSQLVDVYNELAEVILISTDRDSREDLCRIFNVKLIPALVIIPEEKTVTTNAREMVSLYGSRSFFTESRIVELKACLKKEGDSLPRKVKDNKHEHELKLDMAKAYVCDFCK....................... 174
18 -17.400[O] KOG0911 Glutaredoxin-related protein  ali follow..  22  2.........................................................................................................................................................................SGTVKDIVSKAELDNLR--QSGAPVVLHFWASWCDASKQMDQVFSHLATDFPRAHFFRVEAEEHPEISEAYSVAAVPYFVFFKDGKTVDTLEGADPS--SLANKVGKVAG................................................................ 107
19 -15.200[OC] COG4232 Thiol:disulfide interchange protein  ali follow..  12  438................................................................................................................................................................ATHTAQTQTHLNFTQIKTVDELNQALVEAKGKPVMLDLYADWCVACKEFEKY-PQVQKALADTVLLQANVTANDALLKHLNVLGLPTILFFDGQGQEHPQARGFMDAETFSAHLRD................................................................... 562
20 -13.800[O] COG5494 Predicted thioredoxin/glutaredoxin  ali follow..  15  1.................................................................................................................................................................................................MIKIVLHHTCKSSYTLFKALKNTPG------VKFEMASQPYFTYLKNYVLSVPAVFK--DGELY---LLDPVEPDDIKSLIEGRAERELDVDEAVD...................................................... 85
21 -12.400[O] KOG1752 Glutaredoxin and related proteins  ali follow..  18  38................................................................................................................................................................................NLATAPVNQIQETISDNCVVIFSKTSCSYCTMAKKLFHDMNVNYKVVELDLLENQFQDALYKMTGERTVPRIFVFIGGATDTHRLHKEGKLLPLVH....................................................................... 138
22 -12.200[R] COG3054 Predicted transcriptional regulator  ali follow..  53........................................................................................................................................................................................NSAQLAGKVRVLLHIAGRTSAKEKNATLIEAIKSAYQTTTIVNTDVDSNGVARNAWQLEEGSAVIVLDKDGRVQWVKDGALTQQEVQQVVD.................................................................... 177
23 -11.900[S] KOG4498 Uncharacterized conserved protein  ali follow..  2....................................................................................................AIALSSSSTITSITLQPKLKTIHGLGTVLPGYSVKSHFRSVSLRRSAVVVSAITGASSGAGIGKGTADSLDTVKVLDLRGNEIPISDLWKDRKAVVAFAR-GCVLCRKRAAYLAEKKDVMDGVALVLIGPGSIDQANTFVEQTKFKGEVYADPNHASYEALEFVSGVSVTFT....................................................................... 176
24 -11.600[O] COG0695 Glutaredoxin and related proteins  ali follow..  16  4..................................................................................................................................................................................................VEIYTKETCPYCHRAKALLSSKGVSFQELPIDG-NAAKREEMIKRSGRTTVPQIFIHIGGCDDLYALDARGGLDPLLK....................................................................... 83
25 -11.500[O] COG1651 Protein-disulfide isomerase  ali follow..  17  103................................................................................................................................................................TRKNLTEERAADLNKIDFASLPLDKAIRGNGKLKVAVFSDPDCPFCKRLEHEFEKMTDMMPQILWCQPDVAETTSLGEQFGFNGTPTL-VFPNGRSQS----GYSPMPQLEEIIRKN.................................................................. 259
26 -11.500[O] COG4545 Glutaredoxin-related protein  ali follow..  17  4..................................................................................................................................................................................................PILFYAETCPDTAPFVAELDR-----LGVDYDEVEIMTSLPNLKQFGYLGIPALLL............................................................................................. 70
27 -10.300[S] COG4312 Uncharacterized protein conserved in bacteria  ali follow..  8....................................................................................................................................SREEWLVKRRALLAREKEAIHQRDAITAERLALPWVKVDTRYVFDTASGKKTLADLFDGRSQLMIYHAAGCPGCSLVADHLGGTLAHLNDVTLIAVSRAPLPEIEAYRQRMGWQFPWASSFGTTFNHDFRVSFTPDELASGAVDYNYTSTQS----AQANDELPGLSAFYKDEAGNVYHTY.............................. 193
28 -9.440[O] COG0278 Glutaredoxin-related protein  ali follow..  16  2....................................................................................................................................................................................ETLDKIKKQISENPILIYMFPSCGFSARAVEALMHCKVPFGYVDILQ-HPDIRAELPAYANWPTFPQLWVLVGGCDIILEMFQQGELQTLLA....................................................................... 100
29 -9.220[R] KOG2507 Ubiquitin regulatory protein UBXD2, contains UAS and UBX domains  ali follow..  10  14..........................................................................................................................................................................................ASKAKGAVFVVFIEGQDEMTRKLERFVSQVRSRLETSDFVAINSSAYGQFMSLYKIVPIPSLFFIGKTGTPLEIATGVTASVDELTEKIDKVLILAGKRTEPVAASSSSCAKTLDPNEVR..................................... 139

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Zmasek CM, Zhang Q, Ye Y, Godzik A. Surprising complexity of the ancestral apoptosis network. Genome Biol. 2007 Oct 24;8(10):R226 [Epub ahead of print]