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Query: [J] COG0008 Glutamyl- and glutaminyl-tRNA synthetases, from COG1018

Results of FFAS03 search in H.sapiens
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MSEAEARPTNFIRQIIDEDLASGKHTTVHTRFPPEPNGYLHIGHAKSICLNFGIAQDYKGQCNLRFDDTNPVKEDIEYVESIKNDVEWLGFHWSGNVRYSSDYFDQLHAYAIELINKGLAYVDELTPEQIREYRGTLTQPGKNSPYRDRSVEENLALFEKMRAGGFEEGKACLRAKIDMASPFIVMRDPVLYRIKFAEHHQTGNKWCIYPMYDFTHCISDALEGITHSLCTLEFQDNRRLYDWVLDNITIPVHPRQYEFSRLNLEYTVMSKRKLNLLVTDKHVEGWDDPRMPTISGLRRRGYTAASIREFCKRIGVTKQDNTIEMASLESCIREDLNENAPRAMAVIDPVKLVIENYQGEGEMVTMPNHPNKPEMGSRQVPFSGEIWIDRADFREEANKQYKRLVLGKEVRLRNAYVIKAERVEKDAEGNITTIFCTYDADTLSKDPADGRKVKGVIHWVSAAHALPVEIRLYDRLFSVPNPGAADDFLSVINPESLVIKQGFAEPSLKDAVAGKAFQFEREGYFCLDSRHSTAEKPVFNRTVGLRDTWAKVGELast
1 -103.000sp|P07814|SYEP_HUMAN Bifunctional aminoacyl-tRNA synthetase OS=Homo sapiens GN=EPRS PE=1 SV=5 (Range: 151-450)  ali follow..  40  22.TKARVAPEKKQDVGKFVELPGAEMGKVTVRFPPEASGYLHIGHAKAALLNQHYQVNFKGKLIMRFDDTNPEKEKEDFEKVILEDVAMLHIKPDQFT-YTSDHFETIMKYAEKLIQEGKAYVDDTPAEQMKAER----EQRIDSKHRKNPIEKNLQMWEEMKKGSQFGQSCCLRAKIDMSSNNGCMRDPTLYRCKIQPHPRTGNKYNVYPTYDFACPIVDSIEGVTHALRTTEYHDRDEQFYWIIEALGIRKPYIWE-YSRLNLNNTVLSKRKLTWFVNEGLVDGW............................................................................................................................................................................................................................................................................ 300
2 -101.000sp|P47897|SYQ_HUMAN Glutaminyl-tRNA synthetase OS=Homo sapiens GN=QARS PE=1 SV=1 (Range: 301-600)  ali follow..  48  1................................................................RFDDTNPEKEEAKFFTAICDMVAWLGYTPYK-VTYASDYFDQLYAWAVELIRRGLAYVCHQRGEELKGHNTL------PSPWRDRPMEESLLLFEAMRKGKFSEGEATLRMKLVMEDGK---MDPVAYRVKYTPHHRTGDKWCIYPTYDYTHCLCDSIEHITHSLCTKEFQARRSSYFWLCNALDVYCP-VQWEYGRLNLHYAVVSKRKILQLVATGAVRDWDDPRLFTLTALRRRGFPPEAINNFCARVGVTVAQTTMEPHLLEACVRDVLNDTAPRAMAVLESLRVIITNFPAAKSLIQVPNFPADET.................................................................................................................................................................................... 300
3 -89.700sp|Q5JPH6|SYEM_HUMAN Probable glutamyl-tRNA synthetase, mitochondrial OS=Homo sapiens GN=EARS2 PE=1 SV=2  ali follow..  13  10QRERPSAASGRPVGRREANLGTDAGVAVRVRFAPSPTGFLHLGGLRTALYNYIFAKKYQGSFILRLEDTDQTRVVPGAAENIEDMLEWAGIPPDEGPYQQSQRLELYAQATEALLKTGAAYPCFCSPQRLELLKKEALRNHQTPRYDNRCRNMSQEQVAQKLA---KDPKPAIRFRLE--QVVPAFQDLVYGWNRHEVGDPVIMKSDGFPTYHLACVVDDHHMGISHVLRGSEWLVSTAKHLLLYQALGWQPPHFAHLPLLLNRDGSKLSKRQGDVFLEH----------------FAADGFLPDSLLDIITNCGSGFAENQ-MGRTLPELITQFNLTQVTCHSALLDLEKLPEFNRLHLQRLVSNEVEEAFGCQLQNRDVLNPVYVERILLLRQGHICRLQDLVSPVYSYLWTRPAVGRAQLDAISEKVDVIAKRVLGLLERSSMSLTQDMLNGELKKLSEGEGTKYSNVMKLLRMALSGQQQGPPVAEMMLALGPKEVRERIQKVVSS............................................ 523
4 -85.100sp|P07814|SYEP_HUMAN Bifunctional aminoacyl-tRNA synthetase OS=Homo sapiens GN=EPRS PE=1 SV=5 (Range: 301-600)  ali follow..  33  1.......................................................................................................................................AEREQRIDSKHRKNPIEKNLQMWEEMKKGSQFGQSCCLRAKIDMSSNNGCMRDPTLYRCKIQPHPRTGNKYNVYPTYDFACPIVDSIEGVTHALRTTEYHDRDEQFYWIIEALGIRKP-YIWEYSRLNLNNTVLSKRKLTWFVNEGLVDGWDDPRFPTVRGVLRRGMTVEGLKQFIAAQGSSRSVVNMEWDKIWAFNKKVIDPVAPRYVALLKKEVIPVNVPEAQEEMKEVAKHPKNPEVGLKPVWYSPKVFIEGADAET--------FSEGEMVTFINWGNLNITKIHKNADGKIISLDAKLNLENKD.............................................................................................................. 300
5 -81.700sp|P47897|SYQ_HUMAN Glutaminyl-tRNA synthetase OS=Homo sapiens GN=QARS PE=1 SV=1 (Range: 151-450)  ali follow..  49  89..KTPGYVVTPHTMNLLKQHLEITGGQVRTRFPPEPNGILHIGHAKAINFNFGYAKANNGICFLRFDDTNPEKEEAKFFTAICDMVAWLGYTPYK-VTYASDYFDQLYAWAVELIRRGLAYVCHQRGEELKGHNTL------PSPWRDRPMEESLLLFEAMRKGKFSEGEATLRMKLVMEDGK---MDPVAYRVKYTPHHRTGDKWCIYPTYDYTHCLCDSIEH.......................................................................................................................................................................................................................................................................................................................................... 300
6 -74.000sp|P47897|SYQ_HUMAN Glutaminyl-tRNA synthetase OS=Homo sapiens GN=QARS PE=1 SV=1 (Range: 451-750)  ali follow..  37  1................................................................................................................................................................................................................................ITHSLCTKEFQARRSSYFWLCNALDVYCP-VQWEYGRLNLHYAVVSKRKILQLVATGAVRDWDDPRLFTLTALRRRGFPPEAINNFCARVGVTVAQTTMEPHLLEACVRDVLNDTAPRAMAVLESLRVIITNFPAAKLDIQVPNFPADETKGFHQVPFAPIVFIERTDFKEEPEPGFKRLAWGQPVGLRHTGYVELQHVVKGPSGCVESLEVTCRRA------DAGEKPKAFIHWVSQPLMCEVRLYERLHKNPEDPTEVPGGFLSDLNLASLHVVDALVDCSVALAKPFDKFQFERLGYFS............................ 300
7 -59.400sp|P07814|SYEP_HUMAN Bifunctional aminoacyl-tRNA synthetase OS=Homo sapiens GN=EPRS PE=1 SV=5 (Range: 451-750)  ali follow..  23  1..............................................................................................................................................................................................................................................................................................DDPRFPTVRGVLRRGMTVEGLKQFIAAQGSSRSVVNMEWDKIWAFNKKVIDPVAPRYVALLKKEVIPVNVPEAQEEMKEVAKHPKNPEVGLKPVWYSPKVFIEGAD--------AETFSEGEMVTFINWGNLNITKIHKNADGKIISLDAKLNLE------NKDYKKTTKVTWLAETTHIPVICVTYEHLITKPVLGKDEDFKQYVNKNSKHEELMLGDPCLKDLKKGDIIQLQRRGFFICDQ-PYEPVSPYSCKEAPCPDGHTKEMP 261
8 -56.900sp|P07814|SYEP_HUMAN Bifunctional aminoacyl-tRNA synthetase OS=Homo sapiens GN=EPRS PE=1 SV=5 (Range: 1-300)  ali follow..  38  172.TKARVAPEKKQDVGKFVELPGAEMGKVTVRFPPEASGYLHIGHAKAALLNQHYQVNFKGKLIMRFDDTNPEKEKEDFEKVILEDVAMLHIKPDQ-FTYTSDHFETIMKYAEKLIQEGKAYVDDTPAEQMK....................................................................................................................................................................................................................................................................................................................................................................................................................................... 300
9 -41.100sp|P47897|SYQ_HUMAN Glutaminyl-tRNA synthetase OS=Homo sapiens GN=QARS PE=1 SV=1 (Range: 601-775)  ali follow..  34  1......................................................................................................................................................................................................................................................................................................................................................................................KGFHQVPFAPIVFIERTDFKEEPEPGFKRLAWGQPVGLRHTGYIELQHVVKGPSGCVESLEVTCRRA------DAGEKPKAFIHWVSQPLMVRLYERLFQHKNPEDPTEVPGGFLSDLNLASLHVVDALVDCSVALAKPFDKFQFERLGYFSVDP-DSHQGKLVFNRTVTLKEDPGKV.. 175
10 -27.300sp|P47897|SYQ_HUMAN Glutaminyl-tRNA synthetase OS=Homo sapiens GN=QARS PE=1 SV=1 (Range: 1-300)  ali follow..  39  238.YKTPGYVVTPHTMNLLKQHLEITGGQVRTRFPPEPNGILHIGHAKAINFNFGYAKANNGICFL.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 300
11 -16.100sp|P07814|SYEP_HUMAN Bifunctional aminoacyl-tRNA synthetase OS=Homo sapiens GN=EPRS PE=1 SV=5 (Range: 601-900)  ali follow..  21  2...................................................................................................................................................................................................................................................................................................................................................................................................................................................................KKTTKVTWLAETTHIPVICVTYEHLITKPVLGKDEDFKQYVNKNSKHEELMLGDPCLKDLKKGDIIQLQRRGFFICDQPYEPVSPYSCKEAPCVLIYIPDGHT 107
12 -11.800sp|Q15031|SYLM_HUMAN Probable leucyl-tRNA synthetase, mitochondrial OS=Homo sapiens GN=LARS2 PE=1 SV=2 (Range: 1-300)  ali follow..  17  60..EKWWHQRIKEQASKISEADKSKPKFYVLSMFPYPSGKLHMGHVRVYTISDTIARKMRGMQVIN-RNLHPQSWTQSNIKHMRKQLDRLGLCFSEITTCLPDYYKWTQYLFIKLYEAGLAYVNWDPVDQTVLANEQVDEHGCSWRSGAKVEQKYLRQW............................................................................................................................................................................................................................................................................................................................................................................................................ 241
13 -11.600sp|Q96GW9|SYMM_HUMAN(removed signalp:1-15) Methionyl-tRNA synthetase, mitochondrial OS=Homo sapiens GN=MARS2 PE=1 SV=2  ali follow..  13  3LSLLEDFGPRYYSSGSLSAGDDACDVRAYFTTPFYVNAAPHIGHLYSALLADALCRRLRGPFSTGTDELAPTELCDRVSEQFQQLFQEAGISCTD--TTEARHRVAVQHFWGVLKSRGLLYKCFLPEAKVTQQPGPSGDSFPVSLESGHPVSWRLSQFRKPLQRWLRGNPQAIFHHVVLQWLDEELPDLSVSRRSSHLH---------VPIYVWLDALVNYLTVISHIIGKDILKFHAIYWPAFLLGAGMSPPQRICVHSHWTVCGQKMSKSLGNVVDPRTCLNRYT----------------VDGFRYFLLRQGVPNWDCDYYDEKVVKLLNSELADALGGLLNRCTAKRINPSETYPAFCTTCFPSEPGLVGPSVRAQAEDYALVSAVATLPKQVADHYDNFRIYKAL----------EAVSSCVRQTNGFVQRHAPWKLNWESPVDAPWLGTVLHVALE------CLRVFGTLLQPVTPSLADKLLSRLGVSASERSLGELYFLPRFYGHPCPFE---------GRRLGPETGLLFPRLDQSRTWLVKAHR 577
14 -11.400sp|P49589|SYCC_HUMAN Cysteinyl-tRNA synthetase, cytoplasmic OS=Homo sapiens GN=CARS PE=1 SV=3 (Range: 151-450)  ali follow..  12  2......................................LERIQHAVQLAT-KAVQSRLTGDLLSDWLDSTLGCDVTDWEGDFHRDMEALNVLPPDVLTRVSEYVPEIVNFVQKIVDNGYGYVSYFDTAKFASSEKHSYGK------------LVPEAVGDQKALQEGEGDLSISADRLSEKRSPN--DFALWKASKPGEPSWPCPWKGRPGWHIECAMAGTLLGASMDIHG-PHHDNELAQSEAYFENDCWVRYFLHT-GHLTIAGCKMSKS-----------------NFITIKDALKK-HSARQLRLAFLMHSWKDT........................................................................................................................................................................................................................................... 291
15 -9.360sp|Q9P2J5|SYLC_HUMAN Leucyl-tRNA synthetase, cytoplasmic OS=Homo sapiens GN=LARS PE=1 SV=2 (Range: 1-300)  ali follow..  13  17..EKEIQQKWDTERVFEVNASNLEKQTSKGKY-PYMNGRLHLGHTFSLSKCEFAVGRLKGKCCL-LHCTG---PIKACADKLKREIELYGCPPDFPDEEEEEEETSVKTEDIIIKDKAKGKKSKAAAKAGSSKYQWGIMKSLGLSDEEIVKFSEAEHWLDYFPPLAIQDLKRMGLKVDWRRSFITTD............................................................................................................................................................................................................................................................................................................................................................................... 209
16 -9.240sp|P54136|SYRC_HUMAN Arginyl-tRNA synthetase, cytoplasmic OS=Homo sapiens GN=RARS PE=1 SV=2 (Range: 151-450)  ali follow..  11  37....................ALGENKKVIVDFSPNIAKEMHVGHLRSTIIGESISREFAGYDVLRVGDWGTQ------FGMLIAHLQDKFPDYLTVSPPIGD-LQVFYKESKKRFDTEEEFKKRAYQCVVLLQGKNPDITKAWKLICDVSRQELNKIYDALERGESFYQDRMNDIVKEFEDRGFVQVDRKIVFVPGCSIPLTIVKSDGGYTYDLAAIKQDMIIYVV----DNGQSVHFQTIFAAAQMIGWYDP............................................................................................................................................................................................................................................................................................................. 281
17 -9.040sp|Q9HA77|SYCM_HUMAN Probable cysteinyl-tRNA synthetase, mitochondrial OS=Homo sapiens GN=CARS2 PE=1 SV=1  ali follow..  11  62................KEPLIVAHAEAASW--GPTVYDHAHLGHACSYVRFDIIRRKVFGVMVMGITDVDDKSLASLYEEDFKQDMAALKVLPPTVYLRVTENIPQIISFIEGIIARGNAYSTAKGNVYFD-------------------LKSRGDKYGKLVGVVPGP------VGEPADSDKRHASDFALWKAAKPQEVFWASPWPGRPGWHIECAIASMVFGSQLDIHS-HHENEIAQCEVFHQCEQWGNYFLHSGHLHAKGKEEKMSKS-----------------NYITIKDFLKT-FSPDVFRFFCLRSSYRSA--------------DYSDSAMLQAQQLLLGLGSFLEDARAYMKGQLACGSVREAMLWERLSSTKRAVKAALAD-TPRVVDAILGLAHHGNGQLRASLKEPEGPRSPAVFGAIISYFEQFF-ETVGISLANQQYVSGDGSEATLHGVVDELVRFRQKVRQFALAMPEATGDARRQQLLERQPLLEACDTLRR-------GLTAHGINIKDRSSTTSTWELLDQRTKDQKSAG.... 564

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Friedberg I. and Godzik A Connecting the Protein Structure Universe by Using Sparse Recurring Fragments. Structure (Camb.) (2005) Aug;13(8):1213-24