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Query: [J] COG0008 Glutamyl- and glutaminyl-tRNA synthetases, from COG1018

Results of FFAS03 search in H.sapiens
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MSEAEARPTNFIRQIIDEDLASGKHTTVHTRFPPEPNGYLHIGHAKSICLNFGIAQDYKGQCNLRFDDTNPVKEDIEYVESIKNDVEWLGFHWSGNVRYSSDYFDQLHAYAIELINKGLAYVDELTPEQIREYRGTLTQPGKNSPYRDRSVEENLALFEKMRAGGFEEGKACLRAKIDMASPFIVMRDPVLYRIKFAEHHQTGNKWCIYPMYDFTHCISDALEGITHSLCTLEFQDNRRLYDWVLDNITIPVHPRQYEFSRLNLEYTVMSKRKLNLLVTDKHVEGWDDPRMPTISGLRRRGYTAASIREFCKRIGVTKQDNTIEMASLESCIREDLNENAPRAMAVIDPVKLVIENYQGEGEMVTMPNHPNKPEMGSRQVPFSGEIWIDRADFREEANKQYKRLVLGKEVRLRNAYVIKAERVEKDAEGNITTIFCTYDADTLSKDPADGRKVKGVIHWVSAAHALPVEIRLYDRLFSVPNPGAADDFLSVINPESLVIKQGFAEPSLKDAVAGKAFQFEREGYFCLDSRHSTAEKPVFNRTVGLRDTWAKVGELast
1 -103.000sp|P07814|SYEP_HUMAN Bifunctional aminoacyl-tRNA synthetase OS=Homo sapiens GN=EPRS PE=1 SV=5  ali   40  22.TKARVAPEKKQDVGKFVELPGAEMGKVTVRFPPEASGYLHIGHAKAALLNQHYQVNFKGKLIMRFDDTNPEKEKEDFEKVILEDVAMLHIKPDQFT-YTSDHFETIMKYAEKLIQEGKAYVDDTPAEQMKAER----EQRIDSKHRKNPIEKNLQMWEEMKKGSQFGQSCCLRAKIDMSSNNGCMRDPTLYRCKIQPHPRTGNKYNVYPTYDFACPIVDSIEGVTHALRTTEYHDRDEQFYWIIEALGIRKPYIWE-YSRLNLNNTVLSKRKLTWFVNEGLVDGW............................................................................................................................................................................................................................................................................ 300
2 -101.000sp|P47897|SYQ_HUMAN Glutaminyl-tRNA synthetase OS=Homo sapiens GN=QARS PE=1 SV=1  ali   48  1................................................................RFDDTNPEKEEAKFFTAICDMVAWLGYTPYK-VTYASDYFDQLYAWAVELIRRGLAYVCHQRGEELKGHNTL------PSPWRDRPMEESLLLFEAMRKGKFSEGEATLRMKLVMEDGK---MDPVAYRVKYTPHHRTGDKWCIYPTYDYTHCLCDSIEHITHSLCTKEFQARRSSYFWLCNALDVYCP-VQWEYGRLNLHYAVVSKRKILQLVATGAVRDWDDPRLFTLTALRRRGFPPEAINNFCARVGVTVAQTTMEPHLLEACVRDVLNDTAPRAMAVLESLRVIITNFPAAKSLIQVPNFPADET.................................................................................................................................................................................... 300
3 -89.700sp|Q5JPH6|SYEM_HUMAN Probable glutamyl-tRNA synthetase, mitochondrial OS=Homo sapiens GN=EARS2 PE=1 SV=2  ali follow..  13  10QRERPSAASGRPVGRREANLGTDAGVAVRVRFAPSPTGFLHLGGLRTALYNYIFAKKYQGSFILRLEDTDQTRVVPGAAENIEDMLEWAGIPPDEGPYQQSQRLELYAQATEALLKTGAAYPCFCSPQRLELLKKEALRNHQTPRYDNRCRNMSQEQVAQKLA---KDPKPAIRFRLE--QVVPAFQDLVYGWNRHEVGDPVIMKSDGFPTYHLACVVDDHHMGISHVLRGSEWLVSTAKHLLLYQALGWQPPHFAHLPLLLNRDGSKLSKRQGDVFLEH----------------FAADGFLPDSLLDIITNCGSGFAENQ-MGRTLPELITQFNLTQVTCHSALLDLEKLPEFNRLHLQRLVSNEVEEAFGCQLQNRDVLNPVYVERILLLRQGHICRLQDLVSPVYSYLWTRPAVGRAQLDAISEKVDVIAKRVLGLLERSSMSLTQDMLNGELKKLSEGEGTKYSNVMKLLRMALSGQQQGPPVAEMMLALGPKEVRERIQKVVSS............................................ 523
4 -85.100sp|P07814|SYEP_HUMAN Bifunctional aminoacyl-tRNA synthetase OS=Homo sapiens GN=EPRS PE=1 SV=5  ali   33  1.......................................................................................................................................AEREQRIDSKHRKNPIEKNLQMWEEMKKGSQFGQSCCLRAKIDMSSNNGCMRDPTLYRCKIQPHPRTGNKYNVYPTYDFACPIVDSIEGVTHALRTTEYHDRDEQFYWIIEALGIRKP-YIWEYSRLNLNNTVLSKRKLTWFVNEGLVDGWDDPRFPTVRGVLRRGMTVEGLKQFIAAQGSSRSVVNMEWDKIWAFNKKVIDPVAPRYVALLKKEVIPVNVPEAQEEMKEVAKHPKNPEVGLKPVWYSPKVFIEGADAET--------FSEGEMVTFINWGNLNITKIHKNADGKIISLDAKLNLENKD.............................................................................................................. 300
5 -81.700sp|P47897|SYQ_HUMAN Glutaminyl-tRNA synthetase OS=Homo sapiens GN=QARS PE=1 SV=1  ali   49  89..KTPGYVVTPHTMNLLKQHLEITGGQVRTRFPPEPNGILHIGHAKAINFNFGYAKANNGICFLRFDDTNPEKEEAKFFTAICDMVAWLGYTPYK-VTYASDYFDQLYAWAVELIRRGLAYVCHQRGEELKGHNTL------PSPWRDRPMEESLLLFEAMRKGKFSEGEATLRMKLVMEDGK---MDPVAYRVKYTPHHRTGDKWCIYPTYDYTHCLCDSIEH.......................................................................................................................................................................................................................................................................................................................................... 300
6 -74.000sp|P47897|SYQ_HUMAN Glutaminyl-tRNA synthetase OS=Homo sapiens GN=QARS PE=1 SV=1  ali   37  1................................................................................................................................................................................................................................ITHSLCTKEFQARRSSYFWLCNALDVYCP-VQWEYGRLNLHYAVVSKRKILQLVATGAVRDWDDPRLFTLTALRRRGFPPEAINNFCARVGVTVAQTTMEPHLLEACVRDVLNDTAPRAMAVLESLRVIITNFPAAKLDIQVPNFPADETKGFHQVPFAPIVFIERTDFKEEPEPGFKRLAWGQPVGLRHTGYVELQHVVKGPSGCVESLEVTCRRA------DAGEKPKAFIHWVSQPLMCEVRLYERLHKNPEDPTEVPGGFLSDLNLASLHVVDALVDCSVALAKPFDKFQFERLGYFS............................ 300
7 -59.400sp|P07814|SYEP_HUMAN Bifunctional aminoacyl-tRNA synthetase OS=Homo sapiens GN=EPRS PE=1 SV=5  ali   23  1..............................................................................................................................................................................................................................................................................................DDPRFPTVRGVLRRGMTVEGLKQFIAAQGSSRSVVNMEWDKIWAFNKKVIDPVAPRYVALLKKEVIPVNVPEAQEEMKEVAKHPKNPEVGLKPVWYSPKVFIEGAD--------AETFSEGEMVTFINWGNLNITKIHKNADGKIISLDAKLNLE------NKDYKKTTKVTWLAETTHIPVICVTYEHLITKPVLGKDEDFKQYVNKNSKHEELMLGDPCLKDLKKGDIIQLQRRGFFICDQ-PYEPVSPYSCKEAPCPDGHTKEMP 261
8 -56.900sp|P07814|SYEP_HUMAN Bifunctional aminoacyl-tRNA synthetase OS=Homo sapiens GN=EPRS PE=1 SV=5  ali   38  172.TKARVAPEKKQDVGKFVELPGAEMGKVTVRFPPEASGYLHIGHAKAALLNQHYQVNFKGKLIMRFDDTNPEKEKEDFEKVILEDVAMLHIKPDQ-FTYTSDHFETIMKYAEKLIQEGKAYVDDTPAEQMK....................................................................................................................................................................................................................................................................................................................................................................................................................................... 300
9 -41.100sp|P47897|SYQ_HUMAN Glutaminyl-tRNA synthetase OS=Homo sapiens GN=QARS PE=1 SV=1  ali   34  1......................................................................................................................................................................................................................................................................................................................................................................................KGFHQVPFAPIVFIERTDFKEEPEPGFKRLAWGQPVGLRHTGYIELQHVVKGPSGCVESLEVTCRRA------DAGEKPKAFIHWVSQPLMVRLYERLFQHKNPEDPTEVPGGFLSDLNLASLHVVDALVDCSVALAKPFDKFQFERLGYFSVDP-DSHQGKLVFNRTVTLKEDPGKV.. 175
10 -27.300sp|P47897|SYQ_HUMAN Glutaminyl-tRNA synthetase OS=Homo sapiens GN=QARS PE=1 SV=1  ali   39  238.YKTPGYVVTPHTMNLLKQHLEITGGQVRTRFPPEPNGILHIGHAKAINFNFGYAKANNGICFL.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 300
11 -16.100sp|P07814|SYEP_HUMAN Bifunctional aminoacyl-tRNA synthetase OS=Homo sapiens GN=EPRS PE=1 SV=5  ali   21  2...................................................................................................................................................................................................................................................................................................................................................................................................................................................................KKTTKVTWLAETTHIPVICVTYEHLITKPVLGKDEDFKQYVNKNSKHEELMLGDPCLKDLKKGDIIQLQRRGFFICDQPYEPVSPYSCKEAPCVLIYIPDGHT 107
12 -11.800sp|Q15031|SYLM_HUMAN Probable leucyl-tRNA synthetase, mitochondrial OS=Homo sapiens GN=LARS2 PE=1 SV=2  ali   17  60..EKWWHQRIKEQASKISEADKSKPKFYVLSMFPYPSGKLHMGHVRVYTISDTIARKMRGMQVIN-RNLHPQSWTQSNIKHMRKQLDRLGLCFSEITTCLPDYYKWTQYLFIKLYEAGLAYVNWDPVDQTVLANEQVDEHGCSWRSGAKVEQKYLRQW............................................................................................................................................................................................................................................................................................................................................................................................................ 241
13 -11.600sp|Q96GW9|SYMM_HUMAN(removed signalp:1-15) Methionyl-tRNA synthetase, mitochondrial OS=Homo sapiens GN=MARS2 PE=1 SV=2  ali follow..  13  3LSLLEDFGPRYYSSGSLSAGDDACDVRAYFTTPFYVNAAPHIGHLYSALLADALCRRLRGPFSTGTDELAPTELCDRVSEQFQQLFQEAGISCTD--TTEARHRVAVQHFWGVLKSRGLLYKCFLPEAKVTQQPGPSGDSFPVSLESGHPVSWRLSQFRKPLQRWLRGNPQAIFHHVVLQWLDEELPDLSVSRRSSHLH---------VPIYVWLDALVNYLTVISHIIGKDILKFHAIYWPAFLLGAGMSPPQRICVHSHWTVCGQKMSKSLGNVVDPRTCLNRYT----------------VDGFRYFLLRQGVPNWDCDYYDEKVVKLLNSELADALGGLLNRCTAKRINPSETYPAFCTTCFPSEPGLVGPSVRAQAEDYALVSAVATLPKQVADHYDNFRIYKAL----------EAVSSCVRQTNGFVQRHAPWKLNWESPVDAPWLGTVLHVALE------CLRVFGTLLQPVTPSLADKLLSRLGVSASERSLGELYFLPRFYGHPCPFE---------GRRLGPETGLLFPRLDQSRTWLVKAHR 577
14 -11.400sp|P49589|SYCC_HUMAN Cysteinyl-tRNA synthetase, cytoplasmic OS=Homo sapiens GN=CARS PE=1 SV=3  ali   12  2......................................LERIQHAVQLAT-KAVQSRLTGDLLSDWLDSTLGCDVTDWEGDFHRDMEALNVLPPDVLTRVSEYVPEIVNFVQKIVDNGYGYVSYFDTAKFASSEKHSYGK------------LVPEAVGDQKALQEGEGDLSISADRLSEKRSPN--DFALWKASKPGEPSWPCPWKGRPGWHIECAMAGTLLGASMDIHG-PHHDNELAQSEAYFENDCWVRYFLHT-GHLTIAGCKMSKS-----------------NFITIKDALKK-HSARQLRLAFLMHSWKDT........................................................................................................................................................................................................................................... 291
15 -9.360sp|Q9P2J5|SYLC_HUMAN Leucyl-tRNA synthetase, cytoplasmic OS=Homo sapiens GN=LARS PE=1 SV=2  ali   13  17..EKEIQQKWDTERVFEVNASNLEKQTSKGKY-PYMNGRLHLGHTFSLSKCEFAVGRLKGKCCL-LHCTG---PIKACADKLKREIELYGCPPDFPDEEEEEEETSVKTEDIIIKDKAKGKKSKAAAKAGSSKYQWGIMKSLGLSDEEIVKFSEAEHWLDYFPPLAIQDLKRMGLKVDWRRSFITTD............................................................................................................................................................................................................................................................................................................................................................................... 209
16 -9.240sp|P54136|SYRC_HUMAN Arginyl-tRNA synthetase, cytoplasmic OS=Homo sapiens GN=RARS PE=1 SV=2  ali   11  37....................ALGENKKVIVDFSPNIAKEMHVGHLRSTIIGESISREFAGYDVLRVGDWGTQ------FGMLIAHLQDKFPDYLTVSPPIGD-LQVFYKESKKRFDTEEEFKKRAYQCVVLLQGKNPDITKAWKLICDVSRQELNKIYDALERGESFYQDRMNDIVKEFEDRGFVQVDRKIVFVPGCSIPLTIVKSDGGYTYDLAAIKQDMIIYVV----DNGQSVHFQTIFAAAQMIGWYDP............................................................................................................................................................................................................................................................................................................. 281
17 -9.040sp|Q9HA77|SYCM_HUMAN Probable cysteinyl-tRNA synthetase, mitochondrial OS=Homo sapiens GN=CARS2 PE=1 SV=1  ali follow..  11  62................KEPLIVAHAEAASW--GPTVYDHAHLGHACSYVRFDIIRRKVFGVMVMGITDVDDKSLASLYEEDFKQDMAALKVLPPTVYLRVTENIPQIISFIEGIIARGNAYSTAKGNVYFD-------------------LKSRGDKYGKLVGVVPGP------VGEPADSDKRHASDFALWKAAKPQEVFWASPWPGRPGWHIECAIASMVFGSQLDIHS-HHENEIAQCEVFHQCEQWGNYFLHSGHLHAKGKEEKMSKS-----------------NYITIKDFLKT-FSPDVFRFFCLRSSYRSA--------------DYSDSAMLQAQQLLLGLGSFLEDARAYMKGQLACGSVREAMLWERLSSTKRAVKAALAD-TPRVVDAILGLAHHGNGQLRASLKEPEGPRSPAVFGAIISYFEQFF-ETVGISLANQQYVSGDGSEATLHGVVDELVRFRQKVRQFALAMPEATGDARRQQLLERQPLLEACDTLRR-------GLTAHGINIKDRSSTTSTWELLDQRTKDQKSAG.... 564

FFAS is supported by the NIH grant R01-GM087218-01
1 3 2 8 0 9   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Pawlowski K, Rychlewski L, Zhang B, Godzik A. Fold predictions for bacterial genomes. J Struct Biol. 2001 May-Jun;134(2-3):219-31. Review.