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Query: [E] COG0019 Diaminopimelate decarboxylase, from COG1018

Results of FFAS03 search in H.sapiens
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MTFERLGTMNVNAEGHLEIGGVDTLKLTEKYGTPLYVYDVALIRDRARGFKKTFEELGVKAQVAYASKAFSAVAIYQLMAEEGLSLDVVSGGELYTAIKANFPPERIHFHGNNKSAEEIHMALDYGIGCFVIDNYYEISLLEDILIERNEKAAVLIRVTPGIEAHTHDYILTGQDDSKFGFGLTNGQAEKAIKQVLHASASFDLIGLHCHIGSQIFETTGFKLAARRIMDKLVEWHGTLGFDSKVLNLGGGFGVRYTAEDEPLEPSEYVRQIMDEVRDVANSNDIAIPEIWIEPGRSLVGEAGTTLYKVGSRKEVPGIRNYIAVDGGMSDNIRPALYDAHYDAVLAANPEKVAEETVAIAGKCCESGDMLIWDLPLPKSDAGEILAVFCTGAYGYAMASNYNRIPRPPVVFVENGMDKLIVARETYENLVQNDLSLLast
1 -81.100sp|P11926|DCOR_HUMAN Ornithine decarboxylase OS=Homo sapiens GN=ODC1 PE=1 SV=2  ali follow..  21  24..................LDQKINEVSSSDDKDAFYVADLGDILKKHLRWLKAL----PRVTPFYAVKCNDSKAIVKTLAATGTGFDCASKTEIQLVQSLGVPPERIIYANPCKQVSQIKYAANNGVQMMTFDSEVELMKVARAHP----------KAKLVLRIATDDSKAVCRLSVKFGATLRTSRLLLERAKEL----NIDVVGVSFHVGSGCTDPETFVQAISDARCVFDMG-AEVGFSMYLLDIGGGFPGSE---DVKLKFEEITGVINPALDKYFPSD--SGVRIIAEPGRYYVASAFTLAVNIIAKKIVLKETFMYYVNDGVYGSFNCILYDHAHVKPLLQKRPDEKYYSSSIWGPTCDGLDRIVERCDLPEMHVGDWMLFENMGAYTVAAASTFNGFQRPTIYYVMSGPAQLMQQFQNPDFPPEVE... 430
2 -81.000sp|Q96A70|ADC_HUMAN Arginine decarboxylase OS=Homo sapiens GN=ADC PE=2 SV=1  ali follow..  17  17..........FSTRDLLKELTLGASQATTDEVAAFFVADLGAIVRKHFCFLKCL----PRVRPFYAVKCNSSPGVLKVLAQLGLGFSCANKAEMELVQHIGIPASKIICANPCKQIAQIKYAAKHGIQLLSFDNEMELAKVVKSHPS----AKMVLCIA------TDDSHSLSCLSLKFGVSLKSCRHLLENAKKH----HVEVVGVSFHIGSGCPDPQAYAQSIADARLVFEMG-TELGHKMHVLDLGGGFPGTEGAKV---RFEEIASVINSALDLYFPEG--CGVDIFAELGRYYVTSAFTVAVSIIAKKEVLSKTIVYHLDEGVYGIFNSVLFDNICPTPILQKKTEQPLYSSSLWGPAVDGCDCVAEGLWLPQLHVGDWLVFDNMGAYTVGMGSPFWGTQACHITYAMSRVAEALRRQLMAAEQEDDVEGV 434
3 -80.700sp|O14977|AZIN1_HUMAN Antizyme inhibitor 1 OS=Homo sapiens GN=AZIN1 PE=1 SV=2  ali follow..  19  5.......IDDANYSVGLLDEGTNLGNVIDNGKNAFFVGDLGKIVKKHSQWQNVV----AQIKPFYTVKCNSAPAVLEILAALGTGFACSSKNEMALVQELGVPPENIIYISPCKQVSQIKYAAKVGVNILTCDNEIELKKIARNHPN----AKVLLHIA------TEDNIGGEEGNMKFGTTLKNCRHLLECAKEL----DVQIIGVKFHVSSACKESQVYVHALSDARCVFDMA-GEIGFTMNMLDIGGGFTGTEFQLEEVNHVISPLLDIYFPEG--------SGVKIISEPGSYYVSSAFTLAVNIIAKKVVENDKFPSGVEPAFMYYMNDGVYGSFASKLHKKYKEDEPLFTSSLWGPSCDELDQIVESCLLPELNVGDWLIFDNMGADSFHEPSAFNDFQRPAIYYMMSFSYEMQDAGITSDSMMKNFF.. 430
4 -7.630sp|O94903|PROSC_HUMAN Proline synthase co-transcribed bacterial homolog protein OS=Homo sapiens GN=PROSC PE=1 SV=1  ali follow..  10  7....................................MSAELGVGCALRAVNERVQQAVARRRLVAVSKTKPADMVIEAYG---HGQRTFGENYVQELLEKASNPKIL-FIGHLQKQNVNKLMAVPNLFMLTVDSVKLADKVNSSWQRKGSPERLKVMVQ----------INTSGEESKHGLPPSETIAI--VEHINAKCPNLEFVGLMTIGSFGHDLSQGPNPDFQLLLSLREELCKKLNIPADQVELSMGMSADF--------------------------------QHAVEVGSTNVRIGSTIFGERDYSKKPTPDKCAADVKAPLEV.......................................................................................................... 271
5 -6.320sp|Q86VU5|CMTD1_HUMAN(removed signalp:1-26) Catechol O-methyltransferase domain-containing protein 1 OS=Homo sapiens GN=COMTD1 PE=1 SV=1  ali follow..  12  65...........................................................................................AQLLANLARLIQAKKALDLGTGYSALALALALPADGRVVTCEVDAQPPELGRLWRQAEAEHKIDLRLKPALET---DELLAAGEAGTFDVAVVDADKENCSAYYERCLQLLRPGGIRVLWRGKVLQPPKGDVAAECVRNLNERIRRDVRVYISLLPLGDGLTLAFK................................................................................................................................................................................... 235
6 -5.760sp|Q86UW6|N4BP2_HUMAN NEDD4-binding protein 2 OS=Homo sapiens GN=N4BP2 PE=1 SV=2 (Range: 451-750)  ali follow..  10  1.................................................................SGKSF----LARTLQEDNPSGVILSTDDYFYINGQYQFDVKYLGEAHEWNQNRAKEAFEKKISPIIIDNTNEMKPYVALSQKHKYKVLFR-----EPDTWWKFKPKELARRNIHGVSKEKITRMLEHYQRFVSVPII.......................................................................................................................................................................................................................................... 132
7 -5.560sp|Q8N6C5|IGSF1_HUMAN(removed signalp:1-28) Immunoglobulin superfamily member 1 OS=Homo sapiens GN=IGSF1 PE=1 SV=3 (Range: 751-1050)  ali follow..  11  2..................................................................................................FFKTWASPVVTPGARVT---FNCSTPHQHMSFILYKDGSEIASSDRSWASPGASAAHFLIISVGIGDGGNYSCRYYDFSIWS---EPSDPVELVVTEFYPKPTLLAVILRCQGTFQGMRFALLQEGAHVPLQFRSVSGNSADFLLHTVGASGNYSCIYYETTMSNRGSYLSMPLMIWVTDT-----FPKPWLFAEPSSVVPMGQNVTLW----CRGPVHGVGYILHKEGEATSMQLWGSTSNDGAFPITNISGTSMGRYS-----CCYHP---DWTSSIKIQPSNTLELLVTGLLPKPSLL-----AQPGPMVA........................ 300
8 -5.490sp|P52789|HXK2_HUMAN Hexokinase-2 OS=Homo sapiens GN=HK2 PE=1 SV=2 (Range: 751-917)  ali follow..  1...........................................................................................GEIVRNILIDFTKRGLLFRGRISERLKTRGIFETKLSQIESDCLALLQVRAILQHLTCDDSIIVKEVCTVVARRAAQLCGAG---------------MAAVVDRIRENRGLDALKVTVGVDGTLYKLHPHFA--KVMHETVKDLAPKCDVSFLQSEDGSGKGAA..................................................................................................................................................................................... 152
9 -5.490sp|P19367|HXK1_HUMAN Hexokinase-1 OS=Homo sapiens GN=HK1 PE=1 SV=3 (Range: 751-917)  ali follow..  10  1...........................................................................................GEIVRNILIDFTKKGFLFRGQISETLKTRGIFETKLSQIESDRLALLQVRAILQQLG-DDSILVKTVCGVVSRRAAQLCGAG---------------MAAVVDKIRENRGLDRLNVTVGVDGTLYKLHPHFS--RIMHQTVKELSPKCNVSFLLSEDGSGKGAA..................................................................................................................................................................................... 152
10 -5.140sp|Q86WU2|LDHD_HUMAN Probable D-lactate dehydrogenase, mitochondrial OS=Homo sapiens GN=LDHD PE=1 SV=1  ali follow..  12  32.......................VEALKAVVGGSHVSTAAVVREQH--GRDESVHRCEPPDAVVWPQNVEQVSRLAALCYRQGVPIIPFGTG---TGLEGGVCAVQ---GGVCVNLTHMDRILELN-FSVVVEPGVTRKALNAHLRDSG----LWFPVDPGADASLCGMAATGTNAVRYGTMRDNVLNLEVV---LPDGRLLHTAGRGRHFRFGFWPEIPHHTAWYSPCVSLGRRKSAAGYNLTGLFVGGTLGL-LQAAVPVARIEFLDEVMMDACNRYSKLNCLVAPTLFLE----FHGSQQALEEQLQRTEEIVQQNGASDFSWAKEAEERSRLWTARHNAWYAALATRPGCKGYDVCVPISRLPEIVVQTKEDLNASGLTGSIVGHVGDGNFHCILLVNPDDAEELGRVKAFAEQLGRRALALHGTCTGEHGI 468

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Li W, Godzik A. cd-hit: a fast program for clustering and comparing large sets of protein or nucleotide sequences. Bioinformatics. 2006 May 26;