current user: public

Please be advised that we have recently moved our server to a new location. We tried our best to fully test all functions on the website, but if something does not work for you please let us know.

Query: sp|P11766|ADHX_HUMAN Alcohol dehydrogenase class-3 OS=Homo sapiens GN=ADH5 PE=1 SV=4, from H.sapiens

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
    .   10    .   20    .   30    .   40    .   50    .   60    .   70    .   80    .   90    .  100    .  110    .  120    .  130    .  140    .  150    .  160    .  170    .  180    .  190    .  200    .  210    .  220    .  230    .  240    .  250    .  260    .  270    .  280    .  290    .  300    .  310    .  320    .  330    .  340    .  350    .  360    .  370
# Score Template Links and tools%idFirst MANEVIKCKAAVAWEAGKPLSIEEIEVAPPKAHEVRIKIIATAVCHTDAYTLSGADPEGCFPVILGHEGAGIVESVGEGVTKLKAGDTVIPLYIPQCGECKFCLNPKTNLCQKIRVTQGKGLMPDGTSRFTCKGKTILHYMGTSTFSEYTVVADISVAKIDPLAPLDKVCLLGCGISTGYGAAVNTAKLEPGSVCAVFGLGGVGLAVIMGCKVAGASRIIGVDINKDKFARAKEFGATECINPQDFSKPIQEVLIEMTDGGVDYSFECIGNVKVMRAALEACHKGWGVSVVVGVAASGEEIATRPFQLVTGRTWKGTAFGGWKSVESVPKLVSEYMSKKIKVDEFVTHNLSFDEINKAFELMHSGKSIRTVVKILast
1 -109.000[C] COG1062 Zn-dependent alcohol dehydrogenases, class III  ali follow..  62  1.....MKSRAAVAFAPGKPLEIVEIDVAPPKKGEVLIKVTHTGVCHTDAFTLSGDDPEGVFPVVLGHEGAGVVVEVGEGVTSVKPGDHVIPLYTAECGECEFCRSGKTNLCVAVRETQGKGLMPDGTTRFSYNGQPLYHYMGCSTFSEYTVVAEVSLAKINPEANHEHVCLLGCGVTTGIGAVHNTAKVQPGDSVAVFGLGAIGLAVVQGARQAKAGRIIAIDTNPKKFDLARRFGATDCINPNDYDKPIKDVLLDINKWGIDHTFECIGNVNVMRAALESAHRGWGQSVIIGVAGSGQEISTRPFQLVTGRVWKGSAFGGVKGRSQLPGMVEDAMKGDIDLEPFVTHTMSLDEINDAFDLMHEGKSIRTVIRY 369
2 -107.000[Q] KOG0022 Alcohol dehydrogenase, class III  ali follow..  62  4.AGKVIKCKAAVLWELKKPFSIEEVEVAPPKAHEVRIKMVAAGICRSDEHVVSGNLVT-PLPVILGHEAAGIVESVGEGVTTVKPGDKVIPLFTPQCGKCRICKNPESNYCLKNDLGNPRGTLQDGTRRFTCSGKPIHHFVGVSTFSQYTVVDENAVAKIDAASPLEKVCLIGCGFSTGYGSAVKVAKVTPGSTCAVFGLGGVGLSVVMGCKAAGAARIIAVDINKDKFAKAKELGATECINPQDYKKPIQEVLKEMTDGGVDFSFEVIGRLDTMMASLLCCHEACGTSVIVGVPPDSQNLSINPMLLLTGRTWKGAIFGGFKSKESVPKLVADFMAKKFSLDALITNILPFEKINEGFDLLRSGKSIRTVLTF 375
3 -63.000[Q] KOG0023 Alcohol dehydrogenase, class V  ali follow..  23  10....PNKVFGWGARDKSGVLSPFHFSRRDNGENDVTVKILFCGVCHTDLHTIKNDWGYSYYPVVPGHEIVGIATKVGKNVTKFKEGDRVVGVISGSCQSCESCDQDLENYCPQ--------------MSFTYNAIGSDGTKNYGGYSENIVVDQRFVLRFPENLPSDSGAPLLCAGITVYSPMKYYGMTEAGKHLGVAGLGGLGHVAVKIGKAFGLKVTVISSSSTKAEEAINHLGADSFLVTTDPQK------MKAAIGTMDYIIDTISAVHALYPLLGLLKVNGKL-IALGLPEKPLELPMFPL-VLGRKMVGGSDVGG---MKETQEMLDFCAKHNI---TADIELIKMDEINTAMERLAKSDV-RFVIDV 353
4 -61.600[ER] COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases  ali follow..  23  1.......MKAIVWQGVNK-VGVETVPDPTLLPTDAIVKITSTAICGSDLHLLDGYIPSMETGDILGHEFMGEVVEVGSEVRKLKVGDRVVVPFNIACGVCDPCKRGFFSACDNSNPNHRAEALYGATSGGALFGYSHMYGGYAGGQAQYVRVPDVGPFKIESGLKDEQVLFLTDIFPTGYQAAEQCNIVPGRDVVAVFGAGPVGQFAARSAQMLGAAHVIVIDRVPERLAMAEAAGCQTI--NYEKEDVLLSLREATGGRGPDHVIDAVGMETALRWAILSCAKGGTVSMPGVYGGLVDKMPIGAA-FAKGLIFRM---GQTHTHRHIPSLLGRIEAGQIDPSFVITHRASLDQAPELYKTFRDKQCIKVVLN. 389
5 -58.300[R] COG1064 Zn-dependent alcohol dehydrogenases  ali follow..  22  1....MAIARGYAATDASKPLAPFTFERREPRDDDVVIDIKYCGVCHSDIHQARDEWGNSTFPMVPGHEIVGIVRAVGSQVTRFKIGDRVVGCFVDSCTTCAKRDLDLEQYLPG--------------LVVTYNGVEADGTPTQGGYSDHIVVKEGYVLSIPENLPLDAAAPLLCAGITLYSP-LRHWKAGPGKKVAIVGLGGLGHMGVKLAHAMGA-EVTVLSQTLSKKEDGLKLGADHYYATKDPETFTKL------AGSFDLIICTVAAEIDWNAYLNLLKVDGEL-VLVGIPENPVPVHAFSL-VPARRSISGSMIGS---IKETQEMLDFCGEHGI---VSEIETIRMEQINEAYERVVRSDV-RFVIDM 342
6 -57.400[Q] KOG0024 Sorbitol dehydrogenase  ali follow..  21  1MAAAAKPNNLSLVVHGPGDLRLENYPIPEPGPNEVLLRMHSVGICGSDVHYWEYGNFIVKKPMVLGHEASGTVEKVGSSVKHLKPGDRVAIEPGAPRENDEFCKMGRYNLSPSIFFCATPPD---------------------GNLCRFYKHNAAFCYKLPDNVTFEEGALI---LSVGIHAC-RRGGVTLGHKVLVCGAGPIGMVTLLVAKAMGAAQVVVTDLSATRLSKAKEIGADLVLQISKESQEIARKVEGQLGCKPEVTIECTGAEASIQAGIYATRSGGTL-VLVGLGSEMTTVPLLHAAIRE------DIKGVFRYCNTWPVAISMLASKSVNVKPLVTHRFPLEKALEAFETFKKGLGLKIMLK. 349
7 -46.500[CR] KOG1198 Zinc-binding oxidoreductase  ali follow..  22  1.....MALRYVVHDEISGFDQLKPEEYEVPNPGEVLVKLKAASLNYRDLIITKGLYPLPQLPVVPGSDGAGIIEKVGEDVEGFEKGDSVVCNF------FTNYLDGTPTDFATHSAL---GGTRDG------------------CFQKYAVLPAHALVHAPKNLSFEEIATLPCAAVTAWNGLFKEHQVKPGNNVLVLGTGGVSTFALQFALAAGA-NVTVTSSSDEKLEFAKKLGATHTINYKKTPQWASPALKMTNGVGYHHVIEVGG-EKTLPQSIACLAKDGMISMIGFVASEGTTPNLTSIILNRNANIRGIFVGSVSMFRDMVACIEAK-----DIHPVVDKVFPFDQLKEAYEYQWSQAHIGKVVL. 343
8 -42.300[CR] KOG1197 Predicted quinone oxidoreductase  ali follow..  21  2.......VKGIRVYEHGGPLKWEDVEVGEPKEGEIRVKNKAIGLNFIDVYFRKGVYKPASMPFTPGMEAVGEVVAVGSGLTGRMIGDLVAYAGNPM-----------------------------------------------GAYAEEQILPADKVVPVPSSIDPIVAASIMLKGMTAQFLLRRCFKVEPGHTILVHAAGGVGSLLCQWANALGA-TVIGTVSTNEKAAQAKEDGCHHVIMYKN-EDFVSRVNDITSGKGVNVVYDSVG-KDTFKGSLACLKSRGYMVSFGQSSGSPDPIPLSDLAPLTRPSMMHYNETRDELLECAGEVFANVTSGILKA--RVNHKYPLSRVADAHADLENRITSGSVV.. 321
9 -39.500[KC] KOG0025 Zn2+-binding dehydrogenase (nuclear receptor binding factor-1)  ali follow..  20  10ALQRAASTRQLVYEGYRNPIQLKTVTIADPSADQVLVQWIAAPINPADLNQIQGVYPVKPLPAVGGNEGFGKVISVGSNVSSIKVGDHVIPD-------------------------------------------------GLGTWRELGLHQENDLFPIDNTLSMEYAATFQVNPPTAYRMLKDFIDLKKGDTVAQNGASAVGKHVIQICRILGIKTVNVVDNLEELVKELKDLGADEVITQEE------LYSRKKKFPGVKLALNCVG-GRSSLFLASLLDHGGCMVTYGGMSKQPVDCPTGPL-IFKDISLRGFWMSRWYDHEMYQELAGWMKSGEIKKQ--EIVKNRLEDHAKALDTALSKFDKKQFFVL 343
10 -37.800[CR] COG0604 NADPH:quinone reductase and related Zn-dependent oxidoreductases  ali follow..  14  1.......MQALLLEQQDGKASVQTLDESRLPEGDVTVDVHWSSLNYKDALAITGKGKIIRFPMIPGIDFAGTVRTSE--DPRFHAGQEVLLT------------------------GWGVGENHWG------------------GLAEQARVKGDWLVAMPQGLDARKAMIIGTAGFTAMLCVEDAGVRPQDGEIVVTGAGGVGSTAVALLHKLGY-QVVAVSGRESTHEYLKSLGASRILPRDE-----FAESRPLEKQVWAGAIDTVG-DKVLAKVLAQMNYGGCVAACGLAGGFTLPTTVMPF-ILRNVRLQGVDSVMTPPERRAQAWQRLVADLPESFYTQAAKEISLSEAPNFAEAIINNQIQGRTLV. 321
11 -18.700[R] COG2130 Putative NADP-dependent oxidoreductases  ali follow..  20  21.................DNFRLETAQIPELQDGQVLVRNHFLSLDPYMRGRMNDSKSYAQ-PQPLGEIGGTVGVVEASRNPAYAVGDNVV---------------------------------------------------GMFGWQEVGISDGRGMQKVDTRHLSAYLGSVGMPGVTAWYGLNRIMHPKPGQTVAVSAAGAVGSVVGQLAKLKGC-RAVGFAGGKDKCDVVNELGFDACIDAAKDPKELYAMLKEATPDGIDAYFENVG--DILDAVLRRMNPFGRIAMCGMIAGYDGQLQNPQLILVSRLTVEGFIVSEHMDVEALRELGGSVAQGKLKFRESVAQ--GLASAPEAFIGLLKGKNFKQLVKL 335
12 -16.800[R] KOG1196 Predicted NAD-dependent oxidoreductase  ali follow..  17  22.................SDLVITSTTIDLKGSMTALVKNLYLSCMRNRMRKPDPLSPATAQSFTPGKSGFGVSKVIDSGHSDYEEGDLIW---------------------------------------------------GAVGWEEYSVITPIPNLHFHTNFPLSYTGLLGMPGMTAYVGFYEICTPKKGDTVFVSAAGAVGQLVGQFAKLMGC-YVVGSAGSKEKVDLKNKFGFDDAFNYKEEHN-LIGALKRCFPEGIDIYFENVG--KMLDAVILNMRPHGRIAACGMISQYNLKNPEGIYGTYKRIRIEGFNCFDYFHKEFLEFVVPYIKEGKIKYVEDVAD--GLESAPAALVGLFHGKNVKQLVVV 343

FFAS is supported by the NIH grant R01-GM087218-01
1 2 7 8 0 1   jobs submitted since Jan 1, 2011
Comments and questions to: webmaster

Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Zhao Y, Hong DH, Pawlyk B, Yue G, Adamian M, Grynberg M, Godzik A., Li T. The retinitis pigmentosa GTPase regulator (RPGR)- interacting protein: subserving RPGR function and participating in disk morphogenesis. Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):3965-70. Epub 2003 Mar 21.