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Query: sp|Q15758|AAAT_HUMAN Neutral amino acid transporter B(0) OS=Homo sapiens GN=SLC1A5 PE=1 SV=2, from H.sapiens

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MVADPPRDSKGLAAAEPTANGGLALASIEDQGAAAGGYCGSRDQVRRCLRANLLVLLTVVAVVAGVALGLGVSGAGGALALGPERLSAFVFPGELLLRLLRMIILPLVVCSLIGGAASLDPGALGRLGAWALLFFLVTTLLASALGVGLALALQPGAASAAINASVGAAGSAENAPSKEVLDSFLDLARNIFPSNLVSAAFRSYSTTYEERNITGTRVKVPVGQEVEGMNILGLVVFAIVFGVALRKLGPEGELLIRFFNSFNEATMVLVSWIMWYAPVGIMFLVAGKIVEMEDVGLLFARLGKYILCCLLGHAIHGLLVLPLIYFLFTRKNPYRFLWGIVTPLATAFGTSSSSATLPLMMKCVEENNGVAKHISRFILPIGATVNMDGAALFQCVAAVFIAQLSQQSLDFVKIITILVTATASSVGAAGIPAGGVLTLAIILEAVNLPVDHISLILAVDWLVDRSCTVLNVEGDALGAGLLQNYVDRTESRSTEPELIQVKSELPLDPLPVPTEEGNPLLKHYRGPAGDATVASEKESVMLast
1 -88.500[C] COG1301 Na+/H+-dicarboxylate symporters  ali follow..  28  6..................................................FKSLYFQVLTAIAIGILLGHYY----------PELGAQMKPLGDAFVKLIKMIIAPVIFCTVVTGIAGMSMKAVGRTGAVALLYFEIVSTIALIIGLIIVNVVQPGAGMNVDPATLDAQAVAVYAAQ-AKEQGIIAFLMDVIPGSVIGA--------------------------FASGNILQVLLFAVLFGFALHRLGSKGQLIFNVIESFSQVIFGIINMIMRLAPIGAFGAMAFTIGKYG--VGSLVQLGQLIICFYITCILFVVVVLGTIAR-VTGFSIFKFIRYIREELLIVLGTSSSESALPRMLDKM-EKLGCRKSVVGLVIPTGYSFNLDGTSIYLTMAAVFIAQATNSHMDIFHQITLLVVLLLSSKGAAGVTGSGFIVLAATISAVGLPVAGLALILGIDRFMSEARALTNLVGNGVATVVVAKWVKELDHQKLDDVLNNRAPDGKTHEISS............................. 428
2 -84.500[R] COG1823 Predicted Na+/dicarboxylate symporter  ali follow..  21  26.................................................KHVSFSKRVFTALGLGIVFGFALQLIYGPSNIVIQTADWFNIAGGGYVKLLQMVVMPLVFISILGAFTKLLTKNLGKISGLIIGILVATTAVAAAVGIASALSFDLQAIQVDQGSTELSRGQELQQKSEDMTKTLPQQIVELLPGNPFLD-----------------------FTGARPTSTIAVVIFAAFLGVAFLGVPEQAETFKKLVDAVYAIVMRVVTLILRLTPYGVLAIMTKTIATSDLDSI----LKLGMFVIASYAALITMFIIHLLLLTFSGLNPVIYLKKAVPVLVFAFTSRSSAGALPLNIKTQ-RSMGVPEGIANFAGSFGLSIGQNGCAIYPAMLAMMIAPTVGQNFDPVFIITVIAVVAISSFGVAGVGGGATFAALLVLSSLNMPVALAGLLISIEPLIDMGRTALNVSGSMTSGLITSKVTKEIDQGAFHDQSRVIEAEEA................................... 463
3 -77.300[E] COG3633 Na+/serine symporter  ali follow..  19  4..........................................SRLFSLFFQGNLVKRIFIGLILGLLVALVTPTLQN--VLGFNLAEKVGVLGTIFVRSLRAVAPILIFVLVMAAIANKIGAKSNMKS--IIVLYLLGTFLAALSAVIAGFLFPSEVALATK---------EDMTSAPQGVGQVLLTLVFNVVDNPLNA--------------------------LFKANFVGVLAWSIGLGLALRHASESTK---TMVSDLAEAVSKIVYVIIAFAPIGVFGLVSETLADKG--LVALGGYIHLLAVLVGTMLFVAFVVNPILVYWKIRRNPYPVWTCVRESGLTAFFTRSSAANIPVNINLA-KRLNLDEETYSVSIPLGATINMAGAAITVTILTLAAVHTLDIQISFFSALLLSVVASICACGASGVAGGSLLLIPLACSLFGVSDDVIGVGFIIGILQDSTETALNSSTDVLFTAAACIAEENKQ................................................... 412
4 -9.160[P] KOG4505 Na+/H+ antiporter  ali follow..  13  28............................................CSLIIKEKLFLGEATMATATGLIFGPYVAKLFVPTSWGN---------TDYITEELARVLLVVE---VFAAGAELPRAYMLRHWRSMFVMLLPVMIFGWLVSTGFMYALIPR----------------------------LSFLESLAIAACITATDPVLASSIVGKGKFARRVPGHLRNMLLANDGMAIPFLYLAIYLIIEKPARHAGRDWVCIIILYECTFGCV--------LGIIGVIARKMIKFSERRGLMDRESFLVFYFVLALFCGGIGTI---------IGVDDLLVSFCAGAAFSWDSWFSKKT---EESHVSNVIDLLLNLSFFVY-VGAIMDLSVWRLVVLAICILIARRIPAVLLFKSFVPDIINLFAGHFGPIGV--GALYTCLVARAELE-PEPNDAIENPEIPNWYCIQVMWPVVCFLVLSSIIVH......................................................... 427
5 -7.380[K] KOG0870 DNA polymerase epsilon, subunit D  ali follow..  13  9............................................................................................................................................................................................................................................................................................................................................................TSELDDLALPRSI----------MRLVKGVLPEKSLVQKEALKAMINSATLFVSFL-----------------TSASGEIATNNNRKILMPQDVLNALD---------IEYPEFSKTLKKHLEAYELALKEKRLKLPNVSDVDNRKKAKIDAHDTTPLDEEKDELEEERIAEDIAQNEVEQNIDDVEDLEE.. 165
6 -6.870[S] COG2322 Predicted membrane protein  ali follow..  5.................................................................................................................................................................................................................................................GQILSEAPVKKRNYRPMIIILTIVINGLVAVLVHILPMAIFNSFTFLFLLAALIAIKKGNAVVHKRFIYSAFITTSLFLITYVTY-YGGEGIMAGIYYFILFTHIILAALIVPLALTAVARAWNQEHERHRKIVRWTMPLWLYVSLTGVLVYLMISPYY............................................................................................................................................. 185
7 -6.740[P] KOG1966 Sodium/hydrogen exchanger protein  ali follow..  10  51........................................................DSSLLIIVGLGLGYFLNQTTL---------SGVHLDSHAFF----LYLLPPIIFD--AGYFMPNRALFKNFDSVLVFSVLGTLWNTFAIGGSLLIMSK-----------------------YQLFTMPFTTFEILVFSALISAVDPVAVIAIFEEIHVNEFLFINVFGEALFNDGVTVVLYQMFKSFALIGSENLS------PWDYATGGLSFFVVALGGAAIGIIFAIATSLATKYTQGIKILAPVFIFLLPYMAYLTAEMVSLSSIIAIA-----------VCGMLMKQYIKGNITEAATNSVKYFTKMLAQCSETVIFMF-LGLSTHVDFIFIGATLVFCLIYRAIGIKFEVVDQFILSYGGLRGAIAYG-FITTTICVIYFTVFLQGITIRPLVNCLNVKKKEHREATMVESVYNKYLDYMMSGVED...................................................... 456
8 -6.590[E] KOG1286 Amino acid transporters  ali follow..  15  40..................................................AKVLSAFDLTALGIGSTLGVGV----------------YVLAGEVSKQ---AVVVSFLIAAIASIFAGLCYAEFGARSAYIYSYVTIGEFIAFLIGWNLILEYAIG--------------------SASVVKGLSTYLDQLCGNPMSSFLGTHMPLNIEGMGAYPDLF---------AFVVTILFSLAIAVGA------KESTRVNNVFTMLNLGVVLFVIIA------GLFKVSSSNWSIPKSQVPEGYGDGGFMPYGVSGIIKGAAVCF------------YGFI---------CIATAGEEAKNPKK------------------IPFAVIVSL--FLAYFGVSTVLTMMLPYFEQDEKAPLPHVFRINGWHVAEYVVSIGAMFGLCSSMMGAMFPLPRIVFAMSNDGLLFKFLGDISEKYKTPFKGTM........................................................... 386
9 -6.580[K] COG5150 Class 2 transcription repressor NC2, beta subunit (Dr1)  ali follow..  15  1...........................................................................................................................................................................................................................................................................................................................................................MAGDSDNVSLPKAT----------QKMISEILDQDLMFTKDAREIIINSGIEFI-----------MILSSMASEMADNEAKKTIAPEHVIK---ALEELEYN----EFIPFLEEILLNFKGSQKVKETRDSKFKKSGLSEEELLRQQEELFRQSRSRLHHNSVSDPVKSEDSS..................... 146
10 -6.430[JK] KOG2038 CAATT-binding transcription factor/60S ribosomal subunit biogenesis protein  ali follow..  222........................................................................SKTNSQKGASSTWMKAIVSSGTL-MAAMILLI-AVHTLQFVETLVNLVKKKGSK---------QCLMALDTFKELLITDLLPDNRKLRIFSQRPFDKLEQLSSGNKDSRDRRLHQLKHLV-AEFVQVLETLSHDTLVTTKTRALTVAHELLCNKPEEE-------KALLVQVVNKLGDPQNRIATKASHLLETLLCKHPNMKGVVSGEVERLLFRSNISSKAQYYAICFLNQMALS--LANKLITVYFCFFRTCVKKKDVESKMLSALLTGVNRAYPYSQTGDDIDTLFKVLHINFNTSVQALMLLFQVMNSQQTISDRYYTALYRKMLDPGLMTCSKQAMFLNLVYKSLKADIVLRRV--KAFVKGLLQVTCQQMPPFICGALYLVSEILKAKPGLRSQLDDHPESDDEENFIDANDDEDMEKFTDADKETEIVKKLETEETVPETDVETKKPEVASWVHFDNLKG.. 689

FFAS is supported by the NIH grant R01-GM087218-01
1 3 1 8 8 7   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Pawlowski K, Pio F, Chu Z, Reed JC, Godzik A. PAAD - a new protein domain associated with apoptosis, cancer and autoimmune diseases. Trends Biochem Sci. 2001 Feb;26(2):85-7.