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Query: sp|Q99490|AGAP2_HUMAN Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 OS=Homo sapiens GN=AGAP2 PE=1 SV=2 (Range: 301-600), from H.sapiens

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst PATAVTAASAQPPGPAPPITLEPPAPGLKRGREGGRASTRDRKMLKFISGIFTKSTGGPPGSGPLPGPPSLSSGSGSRELLGAELRASPKAVINSQEWTLSRSIPELRLGVLGDARSGKSSLIHRFLTGSYQVLEKTESEQYKKEMLVDGQTHLVLIREEAGAPDAKFSGWADAVIFVFSLEDENSFQAVSRLHGQLSSLRGEGRGGLALALVGTQDRISASSPRVVGDARARALCADMKRCSYYETCATYGLNVDRVFQEVAQKVVTLRKQQQLLAACKSLPSSPSHSAASTPVAGQASLast
1 -61.300[R] KOG0395 Ras-related GTPase  ali follow..  22  1.......................................................................................MMKTLSSGNCTLSVPAKNSYRMVVLGASRVGKSSIVSRFLNGRFDQYTPTIEDFHRKVYNIRGDMYQLDILDTSGNHPFPSILTGDVFILVFSLDNRESFDEVKRLQKQILEVKSKEAAELPMVICG--NKNDHELCRQVPTTEAELLVSGDENCAYFEVSAKKNTNVDEMFYVLFSMAKLPHEMSPALHRKISVQYGDAFHPRRVKEMDAYG 229
2 -60.600[R] KOG0088 GTPase Rab21, small G protein superfamily  ali follow..  17  2...............................................................................................LETNVDQKSFKFKIVLLGEGCVGKSSLVLRFVENKFSKHLSTIQASFQKTVNVEDCQADLHIWDTAGQEKYHYYRGSNGVLLVFDITDRKSFEKVKNWVLEIKTCLGNT-----AEILIVGNKIDLEEERQVTRQDAEAYAESE-GALYMETSAQDNVGISDAFESLTAKMIEHSRTRSTEPPSTNRSIRLIDNDEAERSKKCCR 207
3 -60.000[R] KOG0394 Ras-related GTPase  ali follow..  21  1..................................................................................................MPSRRRTLLKVIILGDSGVGKTSLMNQYVNKKFNQYKATIGADFLKEVQFEDRLFTLQIWDTAGQERFQFYRGADCCVLVYDVNSMKSFENLNNWREEFLIQASSDPENFPFVLIGNKVDVDDGNSRVVSEKKAKAWCASKGNIPYFETSAKVGTNVEEAFQCIAKDALKSGEEEELYLPDTIDVGTSNQQRSTGCEC.... 206
4 -59.700[U] KOG0092 GTPase Rab5/YPT51 and related small G protein superfamily GTPases  ali follow..  19  2.......................................................................................ASRGATRPNGPNTGNKICQFKLVLLGESAVGKSSLVLRFVKGQFHEQESTIGAAFLQTVCLDDTTVKFEIWDTAGQERYHYYRGAQAAIVVYDITNEESFARAKNWVKELQRQASPN-----IVIALSGNKADLANKRAVDFQEAQSYADD-NSLLFMETSAKTSMNVNEIFMAIAKKLPKNEPQNPGANSARGRGVDLTEPTQPTR-NQCCS 214
5 -59.500[U] KOG0095 GTPase Rab30, small G protein superfamily  ali follow..  19  1.................................................................................................MSMEDYDFLFKIVLIGNAGVGKTCLVRRFTQGLFPGQGATIGVGFMKTVEINGEKVKLQIWDTAGQERFRYYRSANALILTYDITCEESFRCLPEWLREIEQYAS---NKVITVLVG--NKIDLAERREVSQQRAEEFSEA-QDMYYLETSAKESDNVEKLFLDLACRLISEARQNTLVNNVSSPLPGEGKSISY---LTCCN 201
6 -59.400[T] KOG4252 GTP-binding protein  ali follow..  24  1.................................................................................................MLEEDMEVAIKMVVVGNGAVGKSSMIQRYCKGIFKDYKKTIGVDFLRQIQVNDEDVRLMLWDTAGQEEFDYYRGAQACVLVFSTTDRGSFEAVSSWREKVVAEVG----DIPTVLVQ--NKIDLLDDSCIKNEEAEALAKRL-RLRFYRTSVKEDLNVNEVFKYLAEKYLQKLKQQIAEDPELTHSSSTSGGSHSGQNSGTLN 210
7 -59.300[U] KOG0094 GTPase Rab6/YPT6/Ryh1, small G protein superfamily  ali follow..  17  1.................................................................................................MASVSPLAKYKLVFLGDQSVGKTSIITRFMYDKFDTYQATIGIDFLKTMYLEDRTVRLQLWDTAGQERFRYIRDSSVAVVVYDVANRLSFLNTSKWIEEVRNERAGD-----VIIVLVGNKTDLVEKRQVSIEEGDSKGREY-GVMFIETSAKAGFNIKPLFRKIAAALPGMESYSNTKNEDDVNLKPTSNSSQGDQQGGACS 206
8 -59.100[U] KOG0093 GTPase Rab3, small G protein superfamily  ali follow..  17  1....................................................................................MASATDSRYGQKESSDQNFDYMFKILIIGNSSVGKTSFLFRYADDSFTAFVSTVGIDFKKTIYRNDKRIKLQIWDTAGQERYRYYRGAMGFILMYDITNEESFNAVQDWSTQIKTYSW---DNAQVLLVG--NKCDMEDERVVSSERGRQLADH-LGFEFFEASAKDNINVKQTFERLVDVICEKMSESLDTADPAKQGPQLSDQQVPPHQDCAC. 220
9 -58.700[U] KOG0087 GTPase Rab11/YPT3, small G protein superfamily  ali follow..  19  5....................................................................................................DEYDYLFKTVLIGDSGVGKSNLLMRFTRNEFNESKSTIGVEFARNIVLDNKKIKAQIWDTAGQERYRYYRGAVGALIVYDITKQSSFDNVGRWLKELREHAD---SNIVIMLVG--NKTDLLHLRAVSTEEAQAFAAE-NNLSFIETSAMDASNVEEAFQTVLTEIFRIVSNRSLEAGDDGVHPTAGQTNKKKSSSQCC. 214
10 -58.600[TU] KOG0084 GTPase Rab1/YPT1, small G protein superfamily, and related GTP-binding proteins  ali follow..  21  1..................................................................................................MNPEYDYLFKLLLIGDSGVGKSCLLLRFADDSYDSYISTIGVDFKRTVEQDGKTIKLQIWDTAGQERFRYYRGAHGIIVTYDVTDLESFNNVKQWLNEIDRYAS---ENVNKLLVG--NKCDLTSQKVVSTETAKAFADE-LGIPFLETSAKNATNVEEAFMAMTAAIKTRMASQPAGGSKPPTVQIRGQPVNQQ--SGCCS 201
11 -58.500[TU] KOG0078 GTP-binding protein SEC4, small G protein superfamily, and related Ras family GTP-binding proteins  ali follow..  17  1.................................................................................................MSTKSYDYLIKLLLIGDSGVGKSCLLLRFSEDSFTSFITTIGIDFKRTIELDGKRIKLQIWDTAGQERFRYYRGAMGILLLYDVTDKKSFDNVRTWFSNVEQHAS---ENVYKILIG--NKCDCEDQRQVSFEQGQALADE-LGVKFLEASAKTNVNVDEAFFTLAREIKKQKIDAENEFSNQANNVDLGNDRTVKRCC.... 200
12 -58.200[U] KOG0098 GTPase Rab2, small G protein superfamily  ali follow..  15  2.....................................................................................................SYAYLFKYIIIGDTGVGKSCLLLQFTDKRFPVHDLTIGVEFGRMVTIDGKQIKLQIWDTAGQESFRYYRGAAGALLVYDITRRDTFNHLTSWLEDARQHSN---SNMVIMLIG--NKSDLEARREVKREEGEAFARE-HGLVFMETSAKTAANVEEAFIDTAKEIYRKIQEGVFDINNEANGIKGNATGGLGGGSGCC. 214
13 -58.200[R] KOG0079 GTP-binding protein H-ray, small G protein superfamily  ali follow..  21  5....................................................................................................RDYDHLFKLLIIGDSGVGKSSLLLRFADNTFENYITTIGVDFKRTMDINGQRVKLQIWDTAGQERFRYYRGTHGVVVVYDVTNGESFGNVKRWLQEIENNC----DSVQKVLVG--NKCEENERRVVLESDARNYAQS-MNISFFETSAKEDKNVEPMFTCITSLVLTAKLANPQSASKDGVSLKDNSGSTNQKKKCKCG 209
14 -58.200[R] KOG0080 GTPase Rab18, small G protein superfamily  ali follow..  20  1..................................................................................................MDEDVLTTLKILIIGESGVGKSSLLLRFTDDTFPELAATIGVDFKKTISVDGNKAKLAIWDTAGQERFRYYRGAQGVILVYDVTRRDTFVKLDNWLNELETYCTRN--DIVNMLVG--NKIDKEN-REVDRNEGLKFARK-HSMLFIEASAKTCDGVQCAFEELVEKIIQTPGLWESENQNKGVKLSHREEGQGGGCGGYCS 204
15 -58.200[U] KOG0086 GTPase Rab4, small G protein superfamily  ali follow..  17  1..................................................................................................MAETYDFLFKFLVIGSAGTGKSCLLHQFIENKFQDSNHTIGVEFGRVVNVGGKTVKLQIWDTAGQERFRYYRGAAGALLVYDITSRETYNSLAAWLTDARTLAS---PNIVVILCG--NKKDLDPEREVTFLEASRFAQE-NELMFLETSALTGENVEEAFLKCARTILNKIDSGELDPERMGSGIQRQPRSAQAVAPQPCG 212
16 -57.700[U] KOG0097 GTPase Rab14, small G protein superfamily  ali follow..  18  6....................................................................................................YNYSYIFKYIIIGDMGVGKSCLLHQFTEKKFADCPHTIGVEFGRIIEVSGQKIKLQIWDTAGQERFRYYRGAAGALMVYDITRRSTYNHLSSWLTDARNLTN---PNTVIILIG--NKADLEAQRDVTYEEAKQFAEE-NGLLFLEASAKTGENVEDAFLEAAKKIYQNIQDGSLDLNAAESGVQHKPSAPQG....... 199
17 -57.600[U] KOG0081 GTPase Rab27, small G protein superfamily  ali follow..  18  1.................................................................................................MSDGDYDYLIKFLALGDSGVGKTSVLYQYTDGKFNKFITTVGIDFRKRVVYRGQRIHLQLWDTAGQERFRFFRDAMGFLLLFDLTNEQSFLNVRNWISQLQMHAYC--ENPDIVLCG--NKSDLEDQRVVKEEEAIALAEK-YGIPYFETSAANGTNISQAIEMLLDLIMKRMERCVDKSWIPEGVVRSNDQLSEEKEKGACG 220
18 -56.000[R] KOG0091 GTPase Rab39, small G protein superfamily  ali follow..  17  1.................................................................................................MVEPIFEYQFRLILIGDSTVGKSSLLKFFTDGKFELSDPTVGVDFFRLIEMDGTQIKLQLWDTAGQERFRYYRNSVGVLLVYDISNHASFEHIPLWMMEAQRHIEPHR----PVFALVGCKLDLINHREVTTEEAQKFAKQ-HGLHFVETSARSGANVEEAFRMVTQEVYARIRSGEYKGFSRPNSLDFNLVVAEPEKSSCC. 218
19 -55.600[R] KOG1673 Ras GTPases  ali follow..  17  90..............................................................................................RFGSSSDSDLVSLKISLLGDCQTGKTTFVVKYVGDENQSFLEMTGLNLMKTFYVQGVTISFSIWDVGGDEK-IACKDAVAILFMFDLTSRSTLNSVFGWYSQARKWN----KTAIPILIG--TKFDDPNLQWTIVTQARAYAKVM-NASLFFSSATHNINVNKIFKFILARLFNLPWKIDRNLTLGE................... 281
20 -53.700[U] KOG0096 GTPase Ran/TC4/GSP1 (nuclear protein transport pathway), small G protein superfamily  ali follow..  15  2...............................................................................................SAPAANGEVPTFKLVLVGDGGTGKTTFVKRHLTGEFEKYIATIGVEVHLSFYTNFGEIKFDVWDTAGQEKFGYYINAQCAIIMFDVTSRITYKNVPNWHRDLVRVC----ENIPIVLCG--NKVDVKERKVK--AKTITFHRK-KNLQYYDISAKSNYNFEKPFLWLARKLAGNPQLEFVASPALAPPDEQLMQQYQQEMEQATA 208
21 -51.000[R] KOG0083 GTPase Rab26/Rab37, small G protein superfamily  ali follow..  19  455............................................................................................SSKAPEEEDEFDIMGKVIMLGDSGVGKTSLLIRFRDGRYSYFLSTVGIDFRKVVVVDGTRVKLQIWDTAGQERFRYYRDAHALLLLYDVTNKTTYDNIRAWLGEIREYAQ---EDVVIVLIG--NKADCSSERQVKREDGERLGRE-HNVPFMETSAKTGLNVELSFTAVARQLKSRGYEHGDDGKFNVHDFVRDNTKARSVCAQCRN 665
22 -43.500[R] KOG0393 Ras-related small GTPase, Rho type  ali follow..  21  1.......................................................................................................MQAIKCVVVGDGAVGKTCLLLSYTTNAFGEYILTVFDTYSTNVMVDGRPINLSLWDTAGQDDYDQFRQTDVFLVCFALNNPASFENVAKWYPEVSHH----CPNTPIILVGTKERLRESRLQPVSHTQGYVMAKEIKAVKYLECSALTQIGLKQVFDEAIRTGLTPPQTPQTRAKKSN................... 191
23 -35.300[R] COG2229 Predicted GTPase  ali follow..  10  1.......................................................................................................MRENKIIFTGPVGVGKTTAIAAISDEALVQTDTTVAMDYGAISL--DEDTKVHLYGTPGQERFNLSQGSMGLVLLLDNARTNPLKDLEFFLHSFRGLL----EKAPVVVGI--TKMDIRSQPGIDVYHKYLAKHNL-NVPVFEIDARKEDDVKQLVSAMLFSIDPGLE............................. 177
24 -29.700[V] KOG1707 Predicted Ras related/Rac-GTP binding protein  ali follow..  15  7..................................................................................................DSSGSPKPIRIVVVGEKGSGKSSLIMAAARNTFHPNIPSLLPYTNLPSEFFPDRIPATVIDTSSRPEDKEVRQADAIVLTFAFDRPETLDRLSKWLPLFRQLE----VRVPIIVAGYEVDNKEAYNHFSIEQITSALMKQYREVTSIQWSAQRLDQAKDVLYYAQKAVI................................. 178
25 -28.700[T] KOG3886 GTP-binding protein  ali follow..  11  6.......................................................................SEKTTEKENLGPRMDPPLGEPEGSLGWVLPNTAMKKKVLLMGKSGSGKTSMRSIIFANYIARLGATILDRIEHSHVRFLGNLVLNLWDCGGQDTFMIFRNVEVLIYVFDVESRELEKDMHYYQSCLEAILQNS-PDAKIFCLV--HKMDLVQEDQRDLEEDLRRLSRPLECSCFRTSI-WDETLYKAWSSIVYQLIPNVQQLE.......................... 249
26 -25.000[R] KOG0074 GTP-binding ADP-ribosylation factor-like protein ARL3  ali follow..  15  17.........................................................................................................EVRILLLGLDNAGKTTLLKQLASEDISHITPTQGFNIKS---VQSQGFKLNVWDIGGQRKIRYFENTDILIYVIDSADRKRFEETGQELAEL--LEEEKLSCVPVLIFA--NKQDLLTAAPASEIAEGLNLHTIRDRVWQSCSALTGEGVQDGMNWVCKNVNAKKK............................. 182
27 -24.700[S] KOG4273 Uncharacterized conserved protein  ali follow..  14  6...........................................................................................................GVLVVGSSGVGKRTLLSRLLSVEFEDSESSSQTEVHGTINTKYYTADVSVCISHICDEYSNSHPLVALVMVFDLSELSTLVALQDWVSHTDINS-------FDILLCIGNKVDRVPHHLAHDEYRRRLLKDIDDFGISETEGSSLLGSEDASLDIRGACLE................................ 176
28 -24.400[U] KOG0072 GTP-binding ADP-ribosylation factor-like protein ARL1  ali follow..  16  17.........................................................................................................EMRILILGLDGAGKTTILYRLQVGEVVTTIPTIGFNVEQ---VTYKNLKFQVWDLGGQTSIRYYSNTDAIIYVVDSADRDRIGISKDELLYM--LREEELAGAILVVLA--NKQDMDGCMTVAEVHHALGLENLKNRTFFKTSATKGEGLDQAMDWLSNTLQSRK.............................. 181
29 -24.200[U] KOG0071 GTP-binding ADP-ribosylation factor Arf6 (dArf3)  ali follow..  13  21.........................................................................................................EMRILMLGLDAAGKTTILYKLKLNQSVVTIPTVGFNVET---VTYKNIKFNVWDVGGQDKIRYFTGTKGLIFVVDSADSNRISEARQELHRI--ISDREMRDCLLLVLA--NKQDLPGALSPAQITDVLQLDKLKDRLWQPTCALTGDGLLEGLAWLSQNAKLK............................... 184
30 -24.100[UZ] KOG0073 GTP-binding ADP-ribosylation factor-like protein ARL2  ali follow..  16  16.........................................................................................................ELRLLMLGLDNAGKTTILKKFNGEDIDTISPTLGFNIKT---LEHRGFKLNIWDVGGQKSLRYFESTDGLIWVVDSADRQRMQDCQRELQSL--LVEERLAGATLLIFA--NKQDLPGALSSNAIREALELDSIRSHHWQGCSAVTGENLLPGIDWLLDDISSRIFTAD.......................... 184
31 -24.000[R] COG1100 GTPase SAR1 and related small G proteins  ali follow..  15  18.........................................................................................................ELRILILGLDGAGKTTILYRLQIGEVVTTKPTIGFNVET---LSYKNLKLNVWDLGGQTSIRYYADTAAVIFVVDSTDKDRMSTASKELHLM--LQEEELQDAALLVFA--NKQDQPGALSASEVSKELNLVELKDRSWVASSAIKGEGITEGLDWLIDVIKEEQ.............................. 182
32 -24.000[U] KOG0070 GTP-binding ADP-ribosylation factor Arf1  ali follow..  12  17.........................................................................................................EMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVET---VEYKNISFTVWDVGGQDKIRYFQNTQGLIFVVDSNDRDRVVEARDELHRM--LNEDELRDAVLLVFA--NKQDLPNAMNAAEITDKLGLHSLRQRHWQSTCATSGEGLYEGLDWLSNNIASK............................... 180
33 -23.900[R] KOG0075 GTP-binding ADP-ribosylation factor-like protein  ali follow..  14  20.........................................................................................................EMELTLVGLQFSGKTTFVNVIASGQFEDMIPTVGFNMRK---ITRGNVTIKVWDIGGQPRFRYCRGVNAIVYMVDAADLDKLEASRNELHSL--LDKPQLAGIPVLVLG--NKRDLPGALDETGLIERMNLSSIQDREIYSISCKEKDNIDITLQWLIQHSKSQSR............................. 186
34 -23.500[U] KOG0077 Vesicle coat complex COPII, GTPase subunit SAR1  ali follow..  14  20.........................................................................................................EAKILFLGLDNAGKTTLLHMLKDERLVQHQPTQHPTSEE---LSIGKIKFKAFDLGGHQIARYYAKVDAVVYLVDAYDKERFAESKRELDAL--LSDEALATVPFLILG--NKIDIPYAASEDEGKVTLGDSGVRPLEVFMCSIVRKMGYGEGFKWLSQYI.................................. 192
35 -22.900[U] KOG0076 GTP-binding ADP-ribosylation factor-like protein yARL3  ali follow..  11  17.........................................................................................................QYSILILGLDNAGKTTFLETLKKKALEKIQPTVG--QNVATIPVDSKQILKFWDVGGQESLRYYSLCHGIIFIVDSSDRERLDECSTTLQSV--VMDEEIEGVPILMLA--NKQDRQDRMEVQD-NKIAEHISARDSRVLPISALTGEGVKDAIEWMIVRLERNKKSRP.......................... 194
36 -19.900[U] KOG0090 Signal recognition particle receptor, beta subunit (small G protein superfamily)  ali follow..  16  57...........................................................................................................TVLLSGLSGSGKTVLFYQLRDGSSHQGAVTSMEPNEGTFVLKGKVKPVHLIDVPGHSRLIYLPRAAAVVFVVDALELPNIRAASEYLYDILTNASVIKNKTPVLLCC--NKTDKVTAHTKEFIRKQSFSHCHNKVTVAEASGLTG-ETDQVQEFIREHV.................................. 258
37 -18.100[R] COG3596 Predicted GTPase  ali follow..  40...........................................................................................................VIGIMGKTGAGKSSLCNALFAGEVSDVAACTRDPLRFRLQIGEHF--MTIVDLPGVGE-EQLPRLDLILWLIKADDRALATD-----EHFYRQVIGEAYRHKMLFV---SQSDKAEPNILSTEQKQNISRKICLLPVCAVSVRLQWGLRVMAERMIKCLPREPSSPVVALLQHPFRTWVAREQARD....... 243
38 -17.500[U] KOG3887 Predicted small GTPase involved in nuclear protein import  ali follow..  20  64...........................................................................................................RILLMGLRRSGKSSIQKKMSPNETLFLESTNKIC-REDVSNSSF-VNFQIWDFPGQIDFFIFRGTGALIFVIDSQDDYM-EALARLHLTVTRAYKVNTDINFEVFIHKVDGLSDDHKIETQRDIHQRANDDLADLSFYLTSI-YDHSIFEAFSKVVQKLIPQLPT............................ 243
39 -17.500[R] COG1084 Predicted GTPase  ali follow..  10  164...........................................................................................................TVVIAGFPNVGKSTLLRTLTGAEVADYPFTTKGIQIGHLERKWKR--IQVIDTPGQAMVALENIADVIMFIFDASETCGYTLESQY----LYLGIRSVFDIPVVTV---NKMDLAENVKYLEEYINMVED------PLKVSAFEGRGVSKIIKKLEGLYEKETREAH.......................... 333
40 -17.100[E] COG4917 Ethanolamine utilization protein  ali follow..  14  3...........................................................................................................RIAFVGSVGAGKTTLFNA-LQGNYTLARKTQAVEFNDKGDI----------DTPGHALITTLQDVDMLIYVHGANDPES---------RLPAGLLDIGVSKRQIAV---SKTDMPDADVAATRK--LLLETGFEEPMFELNSHDPQSVQQLVDYLASLTKQEEAGEKTHHS...................... 158
41 -15.700[R] KOG2486 Predicted GTPase  ali follow..  11  137...........................................................................................................EFALVGRSNVGKSSLLNSLVRRKRLALTSKKPGK-TQCINHFRINDKWYLVDLPGKDYFLNRSTLVSVFLLVDASIPVK-LEYASWLGQ---------NQVPMTLI---TKCDKRKKKKNGGKKPEANIKEFQDLPWIMTSSVTNQGRDEILLHMAQLRNYWLKH............................ 318
42 -15.500[OK] COG0378 Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase  ali follow..  13  5..........................................................................................................LIIGVGGPVGAGKTMLIERLTRYTAIREDASMNFAAIEEMCDKHPDLQLLFLESGGLSATFSPDLVDFSIYIIDVAQ-----------EKIPRKGGQGMIKSDLFII---NKVDLAPYVGANVEVMKADTLKSRNKDFFVTNLKTDEGLKSVADWIEKRLQLALLEE........................... 206
43 -14.600[R] KOG1490 GTP-binding protein CRFG/NOG1 (ODN superfamily)  ali follow..  171............................................................................................................VLICGYPNVGKSSFMNKVTRADFTTKSLFVG-------HTDYKYLRYQVIDTPGMCSITALAHLRAAVLFFLDISGSCGYTIAQQAALFHSIKSLFMNKPLVIVC---NKTDLMPMENISEEDRKLIEEASEEQVLLKMSTLTDEGVMSVKNAACERLLDQRVEAKMKSKKIN................... 364
44 -14.000[M] COG0481 Membrane GTPase LepA  ali follow..  13  6...........................................................................................................NFSIIAHIDHGKSTLSDRLICGGLSDREDSMDLERERGITIDGETYQLNFIDTPGHVDFRSLAACEGALLVVDAGQGVEAQTLANCYTAIEM-------NLEVVPI---NKIDLPAADPERVAEEIEDIVGIDAMEAVRCSAKTGVGIEDVLEEIVHKI.................................. 180
45 -13.700[J] KOG1191 Mitochondrial GTPase  ali follow..  15  354..........................................................................................................LQIAIVGRPNVGKSSLLNAWSKSEVTEVAGTTRDVVEANVTVRG--VPITLLDTAGERSETAAKVADVIIMAVSAVEGRKIQSDKVGVSFYDLFGGLLYLKQPMILV---NKIDCAPPGSCDQLE-DQRKKEEVFHKSVFTSAVTGQGIEELEDAILEIL.................................. 533
46 -13.300[J] KOG0462 Elongation factor-type GTP-binding protein  ali follow..  15  44...........................................................................................................NFGIVAHVDHGKSTLADRLLCGAVPPGQKQMLDKLQQTAALRHRGYLLNLIDTPGHVDFRSLAVCDGILLLVAANQGVQAQTIANFWLAFEK-------NIQIIPV---NKIDLPGADIKSVETQLKNLFEFNPEECLHISAKSGLNVDKVLEAIIDRV.................................. 211
47 -13.000[R] KOG1489 Predicted GTP-binding protein (ODN superfamily)  ali follow..  12  335.........................................................................................................ELKSILIGLPNAGKSTILNKISNAKFTTLSPTIG-----TVSLGFGQDVFTVADIPGIIQLRHIERSNGWVFVLDLSNKNPLNDLQLLIEEVGTLEKVKTK--NILIVC--NKVDIDAEKSESFAKYLQVEKKSQEWDCVPISALREKT.............................................. 499
48 -12.500[R] COG0486 Predicted GTPase  ali follow..  11  228..........................................................................................................MKVVIAGRPNAGKSSLLNALAGREVTDIAGTTRDVLREHIHIDG--MPLHIIDTAGVRAWSEIEQADRILLMLDSTEADNQDL----EKVRSEFLTKLPSNIPVTIV---NKADLSGENEGIVEQNGY--------TVITLSAKTQQGIALLREHLKQSMGYQTNMEG.......................... 395
49 -12.200[R] COG1160 Predicted GTPases  ali follow..  15  216..........................................................................................................IKIAIVGRPNVGKSTLTNRILGEDVFDMPGTTRDSIYIPMERDGQQYTL--IDTAGIKTLQAIQDANVVLLTIDAR-----ENISDQDLSLLGFILNAGRSLVIVV----NKWDGLDQDVKDRVK-SELDRRLDFIDFARISALHGSGVGNLFDSIKEAYACATQK............................ 391
50 -12.200[R] COG1159 GTPase  ali follow..  15  11............................................................................................................IAIVGRPNVGKSTLLNKLLGQKISITSRKAQTTRHRIVGITEGPYQAIYVDTPGKAASSSIGDVELVIFVVEGTRWTPDDEM---------LNKLRDGKAPVILA---NKVDNVQEKVDLLPHLQFLASQMNFLDIVPISAETGMNVDTIAGIVRKHL.................................. 173
51 -12.000[R] KOG0410 Predicted GTP binding protein  ali follow..  11  311...........................................................................................................VVSLVGYTNAGKSTLLNQLTGANFATLDPTT-----RRVQMQNGKEFL-LTDTVGRATLEEIAESSLLVHVVDISHPLAEQQIEAVEKVMSEL---DVSSIPKLVV---NKVDRVDDPQKVKLEAEETGDT------ICISALTGEGLDDFCNAVHEKLKDSMVWVEA......................... 481
52 -11.600[P] COG0370 Fe2+ transport system protein B  ali follow..  16  1.......................................................................................................MSQNTYCILGNPNTGKTSLFNA-LTGSYEYVGNWSGVTVEKKV----RSKTGKLIDLPGIYDLNPISRDETVVCMLNIVDSSQIERNLNLTVQLLEY------GAPVVMG---NMIDVAAGRGIH--NIQNLAKKL-RIPILPVVARSGKGTEDILSTLSEKHVAPAIP............................ 167
53 -11.600[O] KOG0448 Mitofusin 1 GTPase, involved in mitochondrila biogenesis  ali follow..  18  75.........................................................................................................HMKVAFFGRTSSGKSSVINAMLWDKVLPSGIG-TDGDKAYLMTEGSDEKLVLVDSPGTDVDKFCLDADVFVLVANSESTLMNTE-KHFFHKVNEWLSKPN----IFILNNRWDASASEPEYMEDVRRQHMERCLHFLVEELKVANALEAQNRIFFVSAKEVLSARKQKA.......................... 296
54 -11.600[J] KOG0458 Elongation factor 1 alpha  ali follow..  12  84......................PKKPIAAANGSANVTQKLANISISQQRPNDRLPDWLDEEESEGERNGEEANDEKTVQRYYKTTVPTKPKKPHDISAFVKSALPHLSFVVLGHVDAGKSTLMGRLLYDKFAWIMDQTNEERERGVTVS-HRANFTIVDAPGHRDF--ISQADMAILCVDCSTESGFDLDGQTKEHMLLASSLGIHNLIIAM----NKMDNVD----SQQRFEEIKSKLDNINWVPISGFSGEGVYK........................................... 361
55 -11.200[F] COG1618 Predicted nucleotide kinase  ali follow..  11  3..................................................................................................IEGKEKTMLRIAVTGSPGVGKSTVVAKTAEKLAEKPGFKIGGIRTAEIRKEGHREGFSIRDLATGKTGILSHVKG------SGPRLGKYHVNLDDLERIGANAVRNALACDLVVIDEIGPMELISQSVLHHSSRHPLAQRFRGFEVLTVDKG---NRDELPEKITNRFLRK............................... 182
56 -11.100[J] KOG0466 Translation initiation factor 2, gamma subunit (eIF-2gamma; GTPase)  ali follow..  12  18..................................................................................QDLTTLDVTKLTPLSHEVISRQATINIGTIGHVAHGKSTVVKRFKNELERNITIKLGYANAKIYQLDDPS-HVSFVDCPGHDIL--AAVMDAALLLIAGNESCPQPQTSEHLAAIEIM------KLKHILILQ-NKIDLVKERQAKYEQILAFVQGAEGAPIIPISAQLKYNIEVVCEYIVKKIPVPPRDFT.......................... 251
57 -11.000[J] KOG0459 Polypeptide release factor 3  ali follow..  12  4........EAEIRALQLESADENNGVVIPEVHNSHEVENLDKAPEDLKDEVQESIPVPDEQEASEDHDEVMLHPVHNPAKAKEKAAQEKAAKEEAEDVAEANKKRHLNVVFIGHVDAGKSTIGGQILDRQIQKYEKTNEEERLKGKTVE-ESTRFTILDAPGHKSY--ASQADIGVLVISARKETGYERGGQTREHVQLAKTLGVSKLIVVV----NKMDDPTVN--SKERYDEIEQKMKDVVFLPISGLMGKNMDQ........................................... 298
58 -11.000[TU] KOG1954 Endocytosis/signaling protein EHD1  ali follow..  13  95............................................................................................................ILLVGQYSTGKTTFIRYLLESDFPGIREPTTDRFDEEGSIPGNALVVTIVDTPGILSGEFAERVDRIILLFDAHKLDISDEFKRCIEALAGNEDK----IRIVL----NKSDM---------DHQQLMRVYGALMWSLGKVFKTPEVSRVY......................................... 287
59 -11.000[R] COG0536 Predicted GTPase  ali follow..  13  155.........................................................................................................ELKSMLVGFPSAGKSSLISVMSAAKFTTLQPNLGV-----VNVGHETFTMALIPGAGLDFLRHIERTSVLVHVVDTATRDPISDIEALEAELAAYQSALDEDTGLGDLSQRNKADVPEAEE-LAEFLKEDIEKQFGWPVFIISAVARKGLDPLKYKLLEIVQDARKKRPKEKAESV................... 355
60 -11.000[R] COG0218 Predicted GTPase  ali follow..  10  27...........................................................................................................EIALAGRSNVGKSSFINTMLNRKNLARTSGKPGK-TQLLNFFNIDDKMRFVDVPG---YGYARVSKKMIEEY-LTTRENLRAVVSLVDLRHDPSADDVQEIPVIIVATKADKIPRGKWNKHESAIKKKLNFDPSDDFILFSSVSKAGMDEAWDAILEKL.................................. 195
61 -10.900[R] COG2262 GTPases  ali follow..  15  199...........................................................................................................TVSLVGYTNAGKSTLFNRITEARFATLDPTL-----RRIDVADVGETV-LADTVGKATLQETRQATLLLHVIDAADVRVQENIEAVNTVLEEI---DAHEIPTLLV---NKIDM-----LEDFEPRIDRDEENKPIRVWLSAQTGAGIPQLFQALTERLSGEVAQHTL......................... 370
62 -10.700[J] KOG0468 U5 snRNP-specific protein  ali follow..  133...........................................................................................................NVALVGHLHHGKTTFVDCLIRQT-LRYTDTLFTEQERGCSIKQKSYLLNIFDTPGHVNFAAMRMSDGVVLFIDAAEGVMLNTERLL-------KHAVQERQAITVC---NKID-------------------------RLILELKLPPQDAYFKLKHIVEEVN.............................. 288
63 -10.700[R] COG1163 Predicted GTPase  ali follow..  67...........................................................................................................SVGFVGFPSVGKSTLLSKLTGTEFTTLVTVPG-------VIRYKGAKIQMLDLPGKQVIAVARTCNLLFIILDVNK--PLHHKQIIEKELEGVGIRLNKTPPDILIKKKEKGGISITNTVPLTHLGNDEIRAVMSEYRINSAEIAFRCDATVDDLIDVLEASSR............................. 240
64 -10.600[J] KOG0052 Translation elongation factor EF-1 alpha/Tu  ali follow..  15  1...................................................................................................MGKEKVHINIVVIGHVDSGKSTTTGHLIYKKYAWVLDKLKAERERGITID-AKYYITIIDAPGHRDF--TSQADCAVLVVACGTEAGISKNGQTREHALLAQTLGVKQLIVAC----NKMDSTEPP--SEARFTEITNEVKAVPFVPISGFNGDNMLE........................................... 203
65 -10.600[T] KOG1486 GTP-binding protein DRG2 (ODN superfamily)  ali follow..  11  31..........................................................................KAKIAKLRTQLLEPPKGASGGGEGFEVTKYGHGRVALIGFPSVGKSTLLTMLTGTHFTTLTCIPG-------VIHYNDTKIQLLDLPGRQVIAVAKSSDLVLMVLDASKSE--GHRQILTKELEAVGLRLNKTPPQIYF---KKKKTGGISFNTTAPLTHIDEKLCYQILHEYKIHNAEVLFRENATVDDFIDVIEGNRK.......................... 237
66 -10.500[J] COG3276 Selenocysteine-specific translation elongation factor  ali follow..  12  1.............................................................................................................MIIVTSG-GKTALL-KALTGTSTA---HLPEEKKRGMTID-ENKVLGFIDVPGHEKF--LGGVHYAMLIVAADE------AVQTKEHLAILRQLQFHEIIVVI----TKADRTNSAQIEIQTIKQDYSFLRNANYFVTSAETGQGISELRHYLANLAELADTQK........................... 169
67 -10.400[T] COG1217 Predicted membrane GTPase involved in stress response  ali follow..  12  7...........................................................................................................NIAIIAHVDHGKTTLVDKLLSGTLDRKEDSNDQEKERGITILAKNYNINIVDTPGHADFRVMSMVDSVLLVVDAQDGPMPQTRFVTQKAFKA----------LRPIVVVNKIDRPGARPDWVIDQIFDLFDNLGATDEQLDFPIVYASA............................................ 167
68 -10.400[T] KOG1487 GTP-binding protein DRG1 (ODN superfamily)  ali follow..  66...........................................................................................................RIGFVGFPSVGKSTLLSNLAGVYFTTLTTVPG-------VIRYKGAKIQLLDLPGRQVIAVARTCNLILIVLDVLK--PLGHKKIIENELEGFGIRLNSKPPNIGF---KKKDKGGINLTATCPQSELDAE.............................................................. 203
69 -10.300[R] KOG2203 GTP-binding protein  ali follow..  13  43............................................................................................................VAIMGPQSSGKSTLLNHLFKTSFREMDAFAGSQTTKGIWMAGIEPFTIAMDLEGEKQSALFAIAVADIVLINMEQAANKPLLKTVFQVMLRLFSPRKTTL-LFVIRDKTKTPIELLERALREDIQKIWDSVR-----KPEAHKNTPLNEFFN........................................ 212
70 -10.300[R] KOG1533 Predicted GTPase  ali follow..  12  2..........................................................................QMNLNEKKQLLRVRVYATSEKGENLGSTHWTMYGVLVIGAPGAGKSTFCAGLLDPANDTMAYAPDVNITEMITVNDDRLGL-IIDCPGQLELFLEKSGVRLCALHLADSLYCSDPSKFISVALSTLATMVTMEMPQVNC---SKADLFSEDGTYDEAICGVISDFDLVSFVPLAVENKESMMKVIQMVDAAN.................................. 281
71 -10.100[J] KOG0469 Elongation factor 2  ali follow..  11  21...........................................................................................................NMSVIAHVDHGKSTLTDSLVSKA-TRFTDTRKDEQERCITIKYNGFLINLIDSPGHVDFAALRVTDGALVVVDCVSGVCVQTETVL-------RQAIAERIKPVLF---NKMD-------------------------RALLELQLGAEELFQTFQRIVENIN.............................. 198
72 -10.100[P] COG2895 GTPases - Sulfate adenylate transferase subunit 1  ali follow..  14  16..............................................................................................EAWMIAQQHKSLLRFLTCGSVDDGKSTLIGRLLHDDLALLVDGLQAEREQGITID-EKRKFIIADTPGHEQY--ASTCELAILLID-ARKGVLDQTRRHSFISTLL------GIKHLVVAI-NKMDLVD----SEETFTRIREDYLDIRFVPLSALEGDNVAS........................................... 215
73 -9.990[R] COG3911 Predicted ATPase  ali follow..  11  8...........................................................................................................VFVLTGGPGSGKTTLIAALRRAGFATSVVAGRGIVRDQSSIGGTALPWSMLSWEMRSYQNAVEQKGPVFFDRGVPETLGYLRLSPVADHVSTAAKRFRYNPRVFIA-WPDIFAQDEERKQTPDEAKCTYHALAEI--YELVPLPLAPVETRLRFVLADA.................................. 180
74 -9.920[H] COG3172 Predicted ATPase/kinase involved in NAD metabolism  ali follow..  17  10...........................................................................................................TVAILGGESSGKSTLVNKLANIFNTTSAWEYGRDYVFSHLGGDEIAYDKIALGHAQYIDFAVKYANKVAFI-DFVTTQAFCKKGREHPFVQALIDEYRFDL-VILLENNTPWVADGLRSLGSSVDRKEFQNLLVEMLIEFVRVEEEDYDSRFLRCVELVREMMGEQR.......................... 187
75 -9.690[L] KOG1532 GTPase XAB1, interacts with DNA repair protein XPA  ali follow..  13  2..................................................................DPMESSSEQDIVEESQKLVDSLDKLRVSAASSSSNFKKKPIIIIVVGMAGSGKTSFLHRLLDPAVMSLPFGANIDIRDTVKYKEDQLDYVLVDTPGQIEIEAFASTFPTVVTYVVDTPRSSSPITFMSNMLYACSILYKTRLPLVLA---NKTDVADHKTLANSLSLSLYEFYRNIRSVGVSAISGAGMDGFFKAIEASAEEYMET............................ 290

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Grynberg M, Topczewski J, Godzik A., Paszewski A. The Aspergillus nidulans cysA gene encodes a novel type of serine O-acetyltransferase which is homologous to homoserine O-acetyltransferases. Microbiology. 2000 Oct;146 ( Pt 10):2695-703.