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Query: sp|Q9H013|ADA19_HUMAN(removed signalp:1-25) Disintegrin and metalloproteinase domain-containing protein 19 OS=Homo sapiens GN=ADAM19 PE=1 SV=3 (Range: 601-900), from H.sapiens

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst VMTGTKCGYNHICFEGQCRNTSFFETEGCGKKCNGHGVCNNNQNCHCLPGWAPPFCNTPGHGGSIDSGPMPPESVGPVVAGVLVAILVLAVLMLMYYCCRQNNKLGQLKPSALPSKLRQQFSCPFRVSQNSGTGHANPTFKLQTPQGKRKVINTPEILRKPSQPPPRPPPDYLRGGSPPAPLPAHLSRAARNSPGPGSQIERTESSRRPPPSRPIPPAPNCIVSQDFSRPRPPQKALPANPVPGRRSLPRPGGASPLRPPGAGPQQSRPLAALAPKVSPREALKVKAGTRGLQGGRCRVELast
1 -33.300[O] KOG3607 Meltrins, fertilins and related Zn-dependent metalloproteinases of the ADAMs family  ali follow..  27  708VEDGTPCGPSMMCLDRKCLQIQALNMSSCPLDCSGHGVCSNEATCICDFTWAGTDCSIRDPVRNLDEGPKGPSATNLIIGSIAGAILVAAIVLGGTGWGFKNVKKRRFDPTQQGP......................................................................................................................................................................................... 831
2 -26.200[W] KOG3658 Tumor necrosis factor-alpha-converting enzyme (TACE/ADAM17) and related metalloproteases  ali follow..  694LHPGSPCNNYKCDIFRKCRSVDANGLARLKNLLFNKRTIETLTQWAQDNWWVVGVGGLVFLVIMALFVKCCAVHTPS----------------------------------TNPNKPPALNIYQTLTRPGTLIRQHRQRHRAAAGSVPPGPGAQPRSGAASAPSRTTPSARPSAPPLVAPQVAVAVPPGVVGPPIPLIATHPGSSSSTPAVIVLEPPPPYTAADPGSAMGGPRRGHRKNKRQTSSDAAGSSGNGGKKK.......................................... 920
3 -16.000[O] KOG0802 E3 ubiquitin ligase  ali follow..  10  342.............LHAALPDATSEELRAYDDEC----ICREPMACHCLRSW--PTCRKP-------------------------------------------------------VGRTENEVNPRTVEVSSDEQLARQLERQNNPVHALATGLFPAEVPDSVENDTSRNLGLDPSWLQTWSSQGSDVAGPSTTSRTVGLGRVQMMMRHLASVGESYAQTALDDAAWSLWPMNPSQASTSSTTVPPGNGGRTGGLHLRTVSNTTNESLTNILAMAETVREVMPHVPDEIIFQVNFKCILD. 592
4 -15.200[R] KOG2350 Zn-finger protein joined to JAZF1 (predicted suppressor)  ali follow..  10  760...............................................................................................................KKSADQPLSTLANTRERRSEYGQKRNVSGSRLAATPASKRKLSSKDVEQAADAPEVLTHSDNAVDVGIIDDECGGFGAVGVMNGVASPVANNSEMDTEAEVEAEPTATKAITIHCQQPVTTPVAAAATANERLPGVAPHRRGPRRADRREEELVASAPGYRCRPSMRGADAGAAAAAAPHRPPPPPPPQ 955
5 -14.400[O] COG5243 HRD ubiquitin ligase complex, ER membrane component  ali follow..  344.NDDNIC----ICMDELIHSPNQQTWKNKNKKPK----CGHILHLSCLKNW--PICRL-----PVFDEKGNVVQTTFTSNS--------------------------------DITTQTTVTDSTGIATDQQGFANEVDLLPTRTTSPDIRIVPTQNIDTLAMRTRSTSTPSPTWYTFPLHKTGDNSVGSSRSAYEFLITNSDEKENGIPVKLTIENHEVNSLHGDGGEQIAKKIVIPDK............................................................ 546
6 -12.900[O] KOG4275 Predicted E3 ubiquitin ligase  ali follow..  2.....PC---ESC-KRACFD------------C-KRYYCAN---C-CK------RCSV------FAQRPLSRTDLLKLKPKDLI--YLQSKHISTEGCLEKEELVGLVLTHVAQVDRSRGSNASSNSPGRGQANPIDSLKQSCQNFFSNLSDNISDSLASFDSKVTTKPPESRQPEVPTHIFEQPRVSTREIPTYASAVNGGPQHVHVQQQATTTNGGSQSSSSPSTSTQSSNNRDASSSSQAHVAHQEARNEEQEDAQSKSDCECSDEEIMATFSERVSISLKTDTSGRRVNAAAEPSP 276
7 -10.900[K] KOG4218 Nuclear hormone receptor betaFTZ-F1  ali follow..  38....ELC---PVCGDKTCESCKGFFKRTVQNNCIENQNCTQRKRCYCR-------CLSVGM--KLEA-------------------------------VRADRMRGGRNKFGPMYKRDRALKQQKKALIRANGLKLEAMSQVIQAMPSDLTISSAIQNIHSASKGLPLNHAALPPTDYDRSPFVTSPISMTMPPHGSLQGYQTYGHFPSRAIKSEYPDPYTSSPESIMGYSYMDSYQTSSPASIPH...................................................... 257
8 -10.700[R] KOG1312 DHHC-type Zn-finger proteins  ali follow..  10  124PYDYLLYYPAIKC--STCRIVKPAR----SKHCS---ICN---RCHC---WI--NC------GKGN---NSTSTLPRAVLTLTILCGCFTIICAIFTYLQLAIVKEGMTTNEQDKWYTIQEYMREGKLVRSLDDDCPSWFFKCTEQKDDAAEPLQDQHVTFYSTNAYDHKHYNLTHYITIKDASEIP................................................................................................................. 320
9 -10.700[O] KOG0978 E3 ubiquitin ligase involved in syntaxin degradation  ali follow..  35  846.....KCG---VCFDRP--------KEVVIVKC-YHLFCQQ---CKC------PGCGTA---GQND.......................................................................................................................................................................................................................................... 893
10 -10.500[TZ] KOG3671 Actin regulatory protein (Wiskott-Aldrich syndrome protein)  ali follow..  15  325.........................................................................................................................VSVGSLDPSQISSPLPPPIQQHPQMNQSWNQTPVRQYKPSFPSSAPIGSGASSYSTPAAPPPPTRVESHGLAPARPPPPPPSSGTRGIAPSRPLPQAPNYGTPENRPHAVPPPPPPPPPQSFGMAPISSAAPPPPPPPPPMGLPAVGAGAPPPPPPPPPSGAGGPASVLAKLPPAQDGR 503
11 -10.400[O] KOG0320 Predicted E3 ubiquitin ligase  ali follow..  34  262..ELYKC----ICMD------SVSKREPVSTKC-GHVFCRE---CKC------PICNKK................................................................................................................................................................................................................................................. 308
12 -10.400[O] KOG4628 Predicted E3 ubiquitin ligase  ali follow..  231..KYDTCV---ICLED--IEDDKLRV------------CSHPYHTHCIDPW--PICKRK-ASRSRQPSLDNVTDTDDDTTPLLQQQQSNGRQVGQVSSASSAGGAAGSSSSVAAAAVAGTTRHGTFRRGHAGRNPFEESQSSDDENALLASTVRPATSSGAHERINPFDRAPNLPAHLAEQLTESRRSVWSRINFASFFRRQPAVISVAAPPYLERVESGTSAMGLPVTGTIAVASPASNNILNPNLSGSFKDEDDMPPHRSIYEPIAISTPAADSATVDDSAFLQTPTQGGIGVAALPH 527
13 -9.960[R] KOG1311 DHHC-type Zn-finger proteins  ali follow..  10  93VDINGITVRMKWC--VTC---KFYRPPRS-SHCS---VCNR---CHC---WV--NC---GKRN-WSGSDTNARDHILSPPYLCAIVLLALCAVLCVPVIGLTVFHLVLVARGRTTNEQVTGKFTSGYNPFTIGCWGNCKKTLCHSQLPTFKSHVMEFRKQRKEEQARLANRINGPVEEQNAHADDERDETSVLYVPDQKRADGKMVAVVEFNKNNSVLRQQNTTTTTSRSESQNRITESQSQSMSMSSGCDESRITVGGGGGGAEADGSTCNLFEMERGGGRHKKN.............. 392
14 -9.770[O] KOG1571 Predicted E3 ubiquitin ligase  ali follow..  17  284LSQDQLC---VVCSTNP-KEIILL-------PCGHVCLCED---CTC------PVCRGS................................................................................................................................................................................................................................................. 328
15 -9.510[R] KOG3813 Uncharacterized conserved protein (tumor-suppressor AXUD1 in humans)  ali follow..  214...GCDC--RLYCDPEAC-------------ACSQAGICQVDR-CGCSR------CGNM---GRIEFNPIPDEEPSPTASCSLTGAQGSETQDFQEFIAENETAVMHLQSAEELERLKAEEDSSGSSASLDSSIESLGVCILEEPLAVPEELCPGLTAPILIQAQLPPGSSNSGPLVYYQVEQRPVLGVKGEPGTEEGSASFPKEKDLNVFSLPVTSLVACSSTDPAALCKSEVGKTPTLEALLPEDCNPEEPENEDFHPSWSPSSLPFRTDNEEGCGMVKTSQQNEDRPPEDSSLELP. 540
16 -9.380[O] KOG1100 Predicted E3 ubiquitin ligase  ali follow..  22  281RVGMSMC---RSCGKGE-ASVLLL-------PCRHMCLCSV---CTC------PICKSP---ASLH.......................................................................................................................................................................................................................................... 330
17 -9.280[K] KOG1244 Predicted transcription factor Requiem/NEURO-D4  ali follow..  18  296....SDCGRS--CLQ-QCIECKC-----C-NICGTSEFCDD---CHCEGSWSCHLCLDLLKEKASIYQNQNSS................................................................................................................................................................................................................................... 391
18 -9.250[R] KOG4323 Polycomb-like PHD Zn-finger protein  ali follow..  20  187VDMVTLC---SVCQRGHSPLSNRI--------CDG---CNSPYHQLCDAEWFCMKCQYR................................................................................................................................................................................................................................................. 246
19 -9.240[TZ] KOG4035 Coeffector of mDia Rho GTPase, regulates actin polymerization and cell adhesion turnover  ali follow..  3..........KALYDFQAVYPKTISFD--------EGLYQTSAR---QRNW-----SMKGNIGFVPSN-MSKDELLDRLREKKHTMERLYAESSERDGDSSLSYSHSYSDKGSHRHSHPHPTQSQTQLHSQHRQHSPPPSGGSVGSQRLDMSKKSMSSPAVGSSCGLPQNQGMIESPSMGSMQFQGSSCTIQTPQQQQPLPAPPAPAPSPSAASATPTAASTSKAATGGDVAQDNSITSEPSETTTTTTTTSEDVVTTYKETSQMSTSQQHKPQNGSTASASISASASASALRSNGGNGK 317
20 -9.190[O] KOG4265 Predicted E3 ubiquitin ligase  ali follow..  21  273.DNSNEC----VCLSDL-RDTLIL-------PCRHLCLCTS---CNC------PICRLF................................................................................................................................................................................................................................................. 319
21 -9.130[R] KOG0562 Predicted hydrolase (HIT family)  ali follow..  502................................................................................................................VYDKNINGPSVNMMNQNNPNNPFRNTPHLNRQSQKPPHPRSGPRGPMAPWTGPRFPCHQQQNRFRPPGFNACRQPYPPYHSGHQQFPNASSVGGGQTGLPGQGQGPRPKWNSNKIFNQQNRQNTVQAQPQAQNQQTNQQQIQNSNKNQT----PKKKPWKNRLQPVGKVQNQGGANRDPAPPSNSKPS 685
22 -9.090[W] KOG4291 Mucin/alpha-tectorin  ali follow..  473....VSCGVLQTPRFGRKLSFDFMPGAKVSFECNEGFILIGDQRRECSNGWNIPQLKEDPQ-WQMPMLPRSRASSARNLRTL------------------NYDDDSDTDASTLKKTKKWDLDENDEDVTSSEGSQNRNSSKLARDISYINPNVTTGEKPKQLGRRSLHSASGTELDQHGSPVDGDHPDEDDDFDEADVHTGTTHPVGYHQPLSPEEADQLHRQQYSPTFSGLDSRTSGASSINYTPQAATQNRFGGVPVLPSNTQYYSRPPSSVNTVPLRTAPTPLTQDTPSPPLATSP. 798
23 -9.080[O] KOG1645 RING-finger-containing E3 ubiquitin ligase  ali follow..  100.KVTLRD---CLVLSV--------GPAVANTKS-GIS-FASTSGF--------SSDEVEGSLRDVDDEAHKRILFLEAKLRSI......................................................................................................................................................................................................................... 187
24 -9.070[O] KOG0823 Predicted E3 ubiquitin ligase  ali follow..  23  115.....DC---NICLEKAEDPI---------TCC-GHLFC----GCEC------PVCDGEGNGDDCDG-PPRPNAKR................................................................................................................................................................................................................................ 197

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Grynberg M, Topczewski J, Godzik A., Paszewski A. The Aspergillus nidulans cysA gene encodes a novel type of serine O-acetyltransferase which is homologous to homoserine O-acetyltransferases. Microbiology. 2000 Oct;146 ( Pt 10):2695-703.