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Query: gi|15675963|ref|NP_273081.1| 6-phosphogluconate dehydrogenase (NMB0015) [Neisseria meningitidis MC58], from N.meningitidis

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MNGDIGVIGLAVMGQNLILNMNDCGFKVVAYNRTTAKVDEFLNGAAKGTNIIGAYSLQDLVDKLEKPRKIMMMVRAGSVVDEFIEQLLPLLEEGDILIDGGNANYPDTTRRTHYLAEKGILFVGAGVSGGEEGARRGPSIMPGGDKRAWDAVKPIFQAIAAKTSQGEPCCDWVGKDGAGHFVKMVHNGIEYGDMQLICEAYQFMKDGLGLSYDEMYRVFAEWNKTELDSYLIEITAAILGYKDEGGEPLVEKILDTAGQKGTGKWTGINALDLGIPLTLISEAVFARCVSSFKEQRVQTGKLFARTVTPVEGGKQEWVEALRQALLASKIISYAQGFMLIREAGESYGWDLDYGNTALLWREGCIIRSAFLSNIRDAYENNPDLVFLGADPYFKNILENCLPAWRKVVAKAVECGIPMPCMASAITFLDGYTTERLPANLLQAQRDYFGAHTYERTDKPRGEFFHTNWTGKGGDTASTTYDILast
1 -122.000[G] COG0362 6-phosphogluconate dehydrogenase  ali follow..  81  3VKGDIGVIGLAVMGQNLILNMNDHGFKVVAYNRTTSKVDEFLQGAAKGTNIIGAYSLEDLAAKLEKPRKVMLMVRAGDVVDQFIEALLPHLEEGDIIIDGGNSNYPDTNRRVKALAEKGIRFIGSGVSGGEEGARHGPSIMPGGNQEAWQYVKPIFQAISAKTEQGEPCCDWVGGEGAGHFVKMVHNGIEYGDMQLICEAYQFLKEGLGLSYEEMQAIFAEWKNTELDSYLIDITTDILGYKDASGEPLVEKILDTAGQKGTGKWTGINALDFGIPLTLITESVFARCVSSFKDQRVAANQLFGKTITPVEGDKKVWIEAVRKALLASKIISYAQGFMLIREASEQFGWDINYGATALLWREGCIIRSRFLGNIRDAYEANPNLVFLGSDSYFKGILENALSDWRKVVAKSIEVGIPMPCMASAITFLDGYTSARLPANLLQAQRDYFGAHTYERTDKPRGEFFHTNWTGRGGNTASTTYDV 484
2 -118.000[G] KOG2653 6-phosphogluconate dehydrogenase  ali follow..  58  1MSADFGLIGLAVMGQNLILNAADHGFTVCAYNRTQSKVDHFLANEAKGKSIIGATSIEDFISKLKRPRKVMLLVKAGAPVDALINQIVPLLEKGDIIIDGGNSHFPDSNRRYEELKKKGILFVGSGVSGGEEGARYGPSLMPGGSEEAWPHIKNIFQSISAKS-DGEPCCEWVGPAGAGHYVKMVHNGIEYGDMQLICEAYDIMKRLGGFTDKEISDVFAKWNNGVLDSFLVEITRDILKFDDVDGKPLVEKIMDTAGQKGTGKWTAINALDLGMPVTLIGEAVFARCLSALKNERIRASKVLPEVPKDAVKDREQFVDDLEQALYASKIISYAQGFMLIREAAATYGWKLNNPAIALMWRGGCIIRSVFLGQITKAYREEPDLENLLFNKFFADAVTKAQSGWRKSIALATTYGIPTPAFSTALSFYDGYRSERLPANLLQAQRDYFGAHTFRVLPEPVDKDIHINWTGHGGNVSSSTYQA 489
3 -73.200[G] COG1023 Predicted 6-phosphogluconate dehydrogenase  ali follow..  30  1..MQLGMIGLGRMGANIVRRLAKGGHDCVVYDHDPDAVKAMAGED----RTTGVASLRELSQRLSAPRVVWVMVPAGNITTAVIEELANTLEAGDIVIDGGNTYYRDDLRHEKLLFKKGIHLLDCGTSGGVWGRERGYCLMIGGDGDAFARAEPIFATVAPGVAAAEQGYLHCGPCGSGHFVKMVHNGIEYGMMASLAEGLNILRNADVGTRVQHGDAETAPL----------------------------------------------------------------------------------------------------------------------PNPECYQYDFDIPEVAEVWRRGSVIGSWLLDLTAIALRESPDLAEFS-------GRVSDSGEGRWTAIAAIDEGVPAPVLTTALSRFASRDLDDFANKALSAMRKQFGGHAEKPAN......................... 340
4 -61.400[I] COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases  ali follow..  18  2..ETIGFIGLGIMGAPMAGHLLDAGYKVIASDHRSKPLADLVAKGLK-----TVSGHAAVAKAADIIITMVPDTPQVADVLFGDNGVASGLTRGKLVIDMSSISPIETKVFAGKINELGCDYLDAPVSGGEVGAKAALTIMVGGEEKAFERAKPVFEKMGKN-------ITLVGPNGVGQTTKVANQIVVALTIEAVAEALVFASKAGADP----ARVRQALMGGLAASRILEVHGERMVKRTFAPGFRIELHQKDLNLALEGAKALGVSLPNTSTTQQLFNSCAANGGAREDHSAL......................................................................................................................................................................................... 281
5 -19.900[R] COG4007 Predicted dehydrogenase related to H2-forming N5,N10-methylenetetrahydromethanopterin dehydrogenase  ali follow..  3.TMKVAVYGAGNQGSRMAIEFAEAGHDVVLAEPARDMLDDAHWKVVEDAGVTVTDNDAEAASEAEI---AVLFTPFGKKTFEIAKNITNHLPEGAVIANTCTVSPVVLYYVLERELRKDLGIASMHPAAVPGTPQHGHYVIGGHTDEQISRCVELAESCGKVA--------YVVPADVSSAVADMGSLVTAVTLSGVLDYYYVGTQIIRAPKEMVEKQILM..................................................................................................................................................................................................................................................................... 242
6 -16.200[R] COG2085 Predicted dinucleotide-binding enzymes  ali follow..  13  4TKPSIAILGAGRVGSSLARSAVAAGYEVKVAGSGAV--DKIALTAEILMPGAVPSTADQAVKDADIVFLAVPLHK--------FRSVNPATLEGKIVIDTMNTSEIIAEFFAGSTMVKSFNHIGYHEIEQDAGTGRAIAY-ATDDVDAGAQVAQLIKSFGFVPLN-------IGALENGRILE........................................................................................................................................................................................................................................................................................................... 186
7 -14.300[M] COG1004 Predicted UDP-glucose 6-dehydrogenase  ali follow..  12  1..MKVTVFGIGYVGLVQATVLAEVGHDVLCIDIDANKVAPLVKENYEAGRLQFSTDAQAGVAHGVIQFIAVGTPADLKYVLDVASTIGTYMDSPKVIIDKSTVPVGTADKVHQVIQAILEQRIDFSVVSNPEFLKEGAAVIVIGIDTDDSGALELISELYEPFNRNHDRMLVMDIRSA-ELTKYAANGMLATKISFMNEIANIAERLGADIEKVRQDIQALIRTAEDKGYKPQLLQAVEQINNQQKYKLTEFIKSHFNSQLAGKTFAVWGLAFKPNTDDMREAPSRVVMESLWEA----GATIQAYDPEAMDETQRIYGARDDLRLMGTKESALQGADALIICTEWQSFAPDFDMIKSRLKHPVIFDGR................................................................................................................. 421
8 -12.600[EH] COG0059 Ketol-acid reductoisomerase  ali follow..  11  37.GKKIVIVGCGAQGLNQGLNMRDSGLDISYALRPEAIAEKRASFQRATENGFKVGTYEELIPTADLVVNLTPDKQHSKVV----ADVMPLMKKDSAFGYSHGFNRKDITVVMVAPKCPGTEVREEYKRGFGVPTLIAVHPENDPKGEGMAIAKAWAAATGGHK------VLESSFVAEVKSDLMGEQTILCGMLQAGSIVCYDKLVADGKDPAYAGKLIQYGWETITEALKQGGITLMMDRLSNSAKLRAFELAEQIKESLGFLYYKHMDDIISGHFSATMMADWANGDKDLFAWREATGKTAFENAPKYDGKISEQEYFDNGVLMIAMVKAGVEAFDAMVASYEESAYYESLHELPLIAN---TIARKRLYEMNVVISDTAEYGNYLFSNVATPILAKE-------IIPNLQKG----------DLGEPTPAVEVDNITLRDVNDAIRNHPVELIGQELRGYM.................. 482
9 -12.300[M] COG0677 UDP-N-acetyl-D-mannosaminuronate dehydrogenase  ali follow..  15  15.QALIGIVGLGYVGLPLMLRYNAIGFDVLGIDIDDVKVDKLNAG-KARASGFEATTDFSRVSECDALILCVPTPPDMSFVINTTDALKPYLRVGQVVSLESTTYPGTTEEELLPRVQEG----DIYLVYSPEREDPGNPVIGGHTPQCLEVGIALYEQAIDR-------VVPVSSTKAAEMTKLLENIHRAVNIGLVNEMKIVADRMGIDIFEVVDAA........................................................................................................................................................................................................................................................................ 253
10 -12.300[E] COG0287 Prephenate dehydrogenase  ali follow..  14  6MFERIALIGIGLIGSSIARDVRELGLHVVISTRSEDTLKRAEELALGTD---YTVSAAEAVKDAD----LVIVSVPVGASESVAQQIAPYLKPSAIVTDVGSTKASVIAQMAPHMPE-NVHFIPGPLAGTEKGPDAGFAGLFREDAAALERLKDFWRALGSRVDEMDAEHHDKVLAIVSHLPHII--------------AYNIVGTADDLETVTESEVIKYSASGFRDFTRLAASDPTM................................................................................................................................................................................................................................................... 237
11 -11.200[E] KOG2380 Prephenate dehydrogenase (NADP+)  ali follow..  13  364.RLKIGIVGFGNFGQFLGKTMVKQGHTVLAYSRSDYTDE------AAKLGVSYFSDLDDLFEEHPEVIILCTSILSTEKVLESLP--FQRLKRSTLFVDVLSVKEFPRNLFLQTL-PQDFDILCTPMFGPESGKNNNLAFVFD-RKSRCNSFLDIFAREGCRMVEMSC------------GSQFITHTVGRLLEKLSLESTPIDTKGYETLLKLVENTAGD..................................................................................................................................................................................................................................................................... 581
12 -10.500[E] COG0345 Pyrroline-5-carboxylate reductase  ali follow..  15  3.NQKIGFIGAGKMGSALMQGTIKAGINIGASDVYEPFLKDLQAK-----GIRVSTDNAVIVRESDILILAV------QTLSSVLSNLKNEITSEKLVISIAAGVPLSTYEDALLEGTRVVRVMAATVSEAASGIAPGKNA----TPEDLKAALEIFSAVGTAVQVPESLMDAVGLSGSG------------AFIFPVIEAMADGAVLEGMDRKSALTLAAQTVLGA---------AKMALETGMHPGELKDMVTSPAGTTIQGIHSLEEAGIRAAFMNAVIRAS...................................................................................................................................................................................................... 261
13 -10.400[C] COG0240 Glycerol-3-phosphate dehydrogenase  ali follow..  10  1MKQHIGYLGMGIWGFCLASLLANKGYPVVAWSRNPDLIKQLQEERRHPPNLSFTTDMKEAIHNAFMIVEGVTS----AGIRPVAEQLKQITDLSVPFVITSKGIEQNTGLLLSEIMLEVLG--YLGYLSGPSIAKECSVVVSAYDSQTLKQIHEAFDIKGAALGGALKNVIAIA-CGIAEGLSFGNNAKAGLVTRGLHEMRKLAAIMDCKPET-LGDLCVTCFSESSRNLRFGHL---------AQGLTFEQAKAKIGMVVEGAYTALSAYQVA................................................................................................................................................................................................................ 294
14 -10.400[H] COG1893 Ketopantoate reductase  ali follow..  12  3.KPRVAVIGSGSIGLLLYAYLKLANWPALLVTNRPEQADHLNKEGLTFVAKSGEHQPISVTATPLSSFSVGFITVKSFAVKALLPQLQRKKWDGLVFFQNGMTHLEILRQIPARAICCGIVEIGAKRESDVRVQHTGDGIWIGGDSKNFDPMWACLHNAGLKAQKVTN-LTGLFRVKNGALIE--NQLFSLLLKELVKEACVTLGREREVDEAYTRAICDK-TANNLSSMYMDLTHHRRTEIESITGYLIKEAAK................................................................................................................................................................................................................................... 280
15 -10.000[C] COG4074 H2-forming N5,N10-methylenetetrahydromethanopterin dehydrogenase  ali follow..  2IDMKLAILGAGVDEVVVADPVFDNQFTVIDDFAYEDVIGAIHFTHPEDLGFEITTDDREAVADADF---IMTWFPKGDMQPGIIDKFIDDIKPGAIVTHACTIPTTKFYKIFEEKHGETLNVTSYHPGAVPEMKGQVYIAEGYASEEAINTLFELGQKARGN-------AYRLPAELLGPVCDMC-SALTAITYAGILSYRDSVTQVLGAPAGFAQMMAK...................................................................................................................................................................................................................................................................... 292
16 -9.810[E] COG1748 Saccharopine dehydrogenase and related proteins  ali follow..  10  1MKKNVLIIGAGGVAQVVAHKCAQNS-DIHIASRTVDKCRKIVESVREKKSLKTEVKLEAHALDAL------------------VEATKALIVSTGSQIVINVGSAFVNMSVLRACMDTGVAYMDTAIH-AAECKEKGITAILGGFDPGVVNA.......................................................................................................................................................................................................................................................................................................................................... 158
17 -9.750[E] KOG3124 Pyrroline-5-carboxylate reductase  ali follow..  10  1..MSVGFIGAGQLAYALARGFTAAGIKIIASSPEMNLPTVSAL---RKMGVNLTRSNKETVKHSDVLFLAV------HIIPFILDEIGADVQARHIVVSCAAGVTISSVEKKLMAFQPAPKVIRC-MTNTPVVVQEGATVYATGLVEDGQLLEQLMSSVGFCTEVEEDLIDAVGLSGSG------------AYAFMALDALADGGVKMGLPRRLAIQLGAQALLGA---------AKMLLDSEQHPCQLKDNVCSPGGATIHALHFLESGGFRSLLINAVEASC...................................................................................................................................................................................................... 262
18 -9.380[S] COG3804 Uncharacterized conserved protein related to dihydrodipicolinate reductase  ali follow..  10  1MAIPVVQLGTGNVGVHSLRALIAD---TGVWVSSDAKAGKDAAE-ADSTGVRASTDLNAVLATGPRC--AVYNAMADNRLPEALEDYRRILAAGINIVGSGVIPDEIIKPLQDAARAGNSSLYVNGIDPG---ANDLLPMALAGTCESIEQIR--CMEIVDYATYDSAVVMFDVMGFGKPMDQIPMLLQPGVLSLAWGSVVRQLAAGLGISLDGVEEMYV...................................................................................................................................................................................................................................................................... 228
19 -9.080[R] COG1712 Predicted dinucleotide-utilizing enzyme  ali follow..  14  2..LKIGIVGCGFIGGQICRAIDGG---YALCDSSESKALELAAS---KTCKPSYMKIEELIRGVDLIIESASQNAVRFIV-------PQALKAGDVMILGALADEELRDTLFGLAKEHNCKLY-------PSGAVVGIDGLNSASAAGISSVT......................................................................................................................................................................................................................................................................................................................................... 143
20 -9.030[Q] COG5310 Homospermidine synthase  ali follow..  16ITGPVVMIGFGSIGRGTLPLIERHF-RMTVLDPRDTDRKLLDERGIA----------------------FVQEAVTENNYKKLLTPLLTNGGGQGFCVNLSV--DTGSVDLMRLCRKLGVLYIDTVVEPWLGFYF---DAKADNASRTNYALREAMIKEKHDKPGGATVVSTCG-ANPG-----MVSWFVKQALVNLATDLGL....................................................................................................................................................................................................................................................................................... 189

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Ye Y, Osterman A, Overbeek R, Godzik A. Automatic detection of subsystem/pathway variants in genome analysis. Bioinformatics. 2005 Jun 1;21 Suppl 1:i478-i486.