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Query: 3cmq_A mol:protein length:415 Phenylalanyl-tRNA synthetase, mitochondrial, from PDB1018

Results of FFAS03 search in PDB1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MAAECATQRAPGSVVELLGKSYPQDDHSNLTRKVLTRVGRNLHNQQHHPLWLIKERVKEHFYKQYVGRFGTPLFSVYDNLSPVVTTWQNFDSLLIPADHPSRKKGDNYYLNRTHMLRAHTSAHQWDLLHAGLDAFLVVGDVYRRDQIDSQHYPIFHQLEAVRLFSKHELFAGIKDGESLQLFEQSSRSAHKQETHTMEAVKLVEFDLKQTLTRLMAHLFGDELEIRWVDCYFPFTHPSFEMEINFHGEWLEVLGCGVMEQQLVNSAGAQDRIGWAFGLGLERLAMILYDIPDIRLFWCEDERFLKQFCVSNINQKVKFQPLSKYPAVINDISFWLPSENYAENDFYDLVRTIGGDLVEKVDLIDKFVHPKTHKTSHCYRITYRHMERTLSQREVRHIHQALQEAAVQLLGVEGRFLast
1 -142.0003cmq_A mol:protein length:415 Phenylalanyl-tRNA synthetase, mitochondrial  ali model  100  1MAAECATQRAPGSVVELLGKSYPQDDHSNLTRKVLTRVGRNLHNQQHHPLWLIKERVKEHFYKQYVGRFGTPLFSVYDNLSPVVTTWQNFDSLLIPADHPSRKKGDNYYLNRTHMLRAHTSAHQWDLLHAGLDAFLVVGDVYRRDQIDSQHYPIFHQLEAVRLFSKHELFAGIKDGESLQLFEQSSRSAHKQETHTMEAVKLVEFDLKQTLTRLMAHLFGDELEIRWVDCYFPFTHPSFEMEINFHGEWLEVLGCGVMEQQLVNSAGAQDRIGWAFGLGLERLAMILYDIPDIRLFWCEDERFLKQFCVSNINQKVKFQPLSKYPAVINDISFWLPSENYAENDFYDLVRTIGGDLVEKVDLIDKFVHPKTHKTSHCYRITYRHMERTLSQREVRHIHQALQEAAVQLLGVEGRF 415
2 -65.7003pco_A mol:protein length:327 Phenylalanyl-tRNA synthetase, alpha subunit  ali model follow..  30  65.......EQVQQALNARKAELESAALNARLETIDVSLPGRRIENGGLHPVTRTIDRIESFFGELGFTVATGP---------EIEDDYHNFDALNIPGHHPARADHDTFWFDTTRLLRTQTSGVQIRTMKAQPPIRIIAPGRVYRNDYDQTHTPMFHQMEGLIVDT-----------------------------------NISFTNLKGTLHDFLRNFFEEDLQIRFRPSYFPFTEPSAEVDVMGKNKWLEVLGCGMVHPNVLRNVGIDPESGFAFGMGMERLTMLRYGVTDLRSFFENDLRFLKQFK........................................................................................................... 327
3 -65.2003l4g_A mol:protein length:508 Phenylalanyl-tRNA synthetase alpha chain  ali model follow..  16  183.......TSISKQETELSPEMISSGSWRDRKPYNFLAHGVLPDSGHLHPLLKVRSQFRQIFLEMGFTEM--------PTDNFIESSFWNFDALFQPQQHPARDQHDTFFLRDPAEALQLPMDYVQRVKRTHSQGYGSQGYKYNWKLDEARKNLLRTHTTSASARALYRLAPVKYFSIDRVFRNETLDATHLAEFHQIEGVVADLGHLMGVLREFFTKLGIT--QLRFKPAYNPYTEPSMEVFSYHLKKWVEVGNSGVFRPEMLLPMGLPENVVIAWGLSLERPTMIKYGINNIRELVGHKVNLQMVYD----SPLCRLDAEPRPPPTQE...................................................................................... 506
4 -63.6002rhq_A mol:protein length:294 Phenylalanyl-tRNA synthetase alpha chain  ali model follow..  27  3....SSSSGLVPRGSHMGTELMEKLNQQAEETIDVTLPSRQISIGSKHPLTRTVEEIEDLFLGLGYEIVDGY---------EVEQDYYNFEALNLPKSHPARDMQDSFYITDEILMRTHTSPVQARTMEKRPVKIICPGKVYRRDSDDATHSHQFTQIEGLVVDK-----------------------------------NIKMSDLKGTLELVAKKLFGADREIRLRPSYFPFTEPSVEVDVSCHTGWIEILGAGMVHPNVLEMAGFDSNSGFAFGMGPDRIAMLKYGIEDIRYFYTNDVRFLEQFKAVEDRGE.................................................................................................... 288
5 -61.7004p71_C mol:protein length:338 Phenylalanine--tRNA ligase alpha subunit  ali model follow..  29  60INVAKEKVQDVLNARKTELEGAALAARLAAERIDVTLPGRGQLSGGLHPVTRTLERIEQCFSRIGYEVAEGP---------EVEDDYHNFEALNIPGHHPARAMHDTFYFNANMLLRTHTSPVQVRTMESPPIRIVCPGRVYRCDSDLT-HSPMFHQVEGLLVDE-----------------------------------GVSFADLKGTIEEFLRAFFEKQLEVRFRPSFFPFTEPSAEVDIQCQTGWLEVMGCGMVHPNVLRMSNIDPEQGFAFGMGAERLAMLRYGVNDLRLFFDNDLRFLGQFR........................................................................................................... 338
6 -59.8001b70_A mol:protein length:350 PHENYLALANYL-TRNA SYNTHETASE  ali model follow..  28  53..ELNAIKAALEAALEAREKALEEAALKERERVDVSLPGASLFSGGLHPITLMERELVEIFRALGYQAVEGP---------EVESEFFNFDALNIPEHHPARDMWDTFWLTGELLLRTHTSPMQVRYMVAPPFRIVVPGRVFRFEQTDATHEAVFHQLEGLVV-----------------------------------GEGIAMAHLKGAIYELAQALFGPDSKVRFQPVYFPFVEPGAQFAVWWPGKWLELGGAGMVHPKVFQAVDAYRERGFAFGLGVERLAMLRYGIPDIRYFFGGRLKFLEQFK........................................................................................................... 347
7 -48.2005x6c_A mol:protein length:553 O-phosphoserine--tRNA(Cys) ligase  ali model follow..  14  116.................................RPDVGLGNEKVEIIKNLGIDIDEEKKERLREVLHLYKKGAIDGDD------LVFEIAKALNVSNEMGLKVLETAFPESTTLTLRSHMTSGWFITLSSLPLKLFSIDRCFRREQEDRSHLMSYHSASCVVV-----------------------------------GEDVSVDDGKVVAEGLLAQFGFTKFKFKPDEKKSKYYTPETQTEVYALGEWIEVATFGVYSPIALAKYNIDVPV-MNLGLGVERLAMIIYGYEDVRAMVYPQFYEYRLSD----RDIAGMIRVDKVPILDYNFANELIDICIANKDKES-----------SVEVKREFNFNGERRVIKVEIFENEPNKKLLGPSVLNEVYIPILKKAKEEVSTNIRY 483
8 -46.6003pco_B mol:protein length:795 Phenylalanyl-tRNA synthetase, beta chain  ali model follow..  15  446.AVAPSWRFDMEIEEDLVEEVARVYGYNNIPD---EPVQASLIMGTHREADLSLKRVKTLLNDKGYQEVITYSFVDPKVQQMIHPGVEA-----LLLPSPI--SVEMSAMRLSLWTGLLATVVYNQNRQQNRVRIFESGLRFVPDTQAPL------------------------GIRQDLMLAGVICGNRYEEHWNLAKETVDFYDLKGDLESVLDLTGKLN-EVEFRAEANPALHPGQSAAIYLKGE--RIGFVGVVHPELERKLDLNGRT-LVFELEWNKLADRV---------------------------VPQAREISRFPANRRDIAVVVAEN-VPAADILSECKKVGVNQVVGVNLFDVYRGKAEGYKSLAISLILQDTSRTLEEEEIAATVAKCVEALKERFQASLR. 794
9 -46.5002du3_A mol:protein length:534 O-phosphoseryl-tRNA synthetase  ali model follow..  12  6........QKYRELAEKDFEAAWKAGKEAERSPNELYPRVGFSFGKEHPLFATIQRLREAYLSIGFSEVVNPLIVEKGEIDGDDLSYLIAEVLDVDDITAVKILDEVFPISSTLTLRSHMTTGWFITLSHLPIKLFSIDRCFRREQEDATRLYTYFSASCVLV-----------------------------------DEELSVDDGKAVAEALLRQFGFENFRFRKDEKRSKYYIPDTQTEVFASDGWIEIATFGIYSPTALAEYDIPYP-VMNLGLGVERLAMILYGYDDVRKMVYPQIHGEIKLS---DLDIAREIKVKEVPQTAVGLKIAQSASEPSPCSFLAFEGEMMGRNVR-VYVVEEEENTKLGPAYANEVVVYKGDIYGIPKTK------KWRSFFEEGVPTGIRY 464
10 -44.4004p71_A mol:protein length:792 Phenylalanine--tRNA ligase beta subunit  ali model follow..  14  446.VGVPSHRFDISLEVDLIEELARLYGYNRLPV---RYPQARLAPNNKPEARAALPLLRRLLVARGYQEAITFSFIDPALFELFDPGTQP-----LTLANPI--SADMAAMRSSLWPGLVKALQHNLNRQQSRVRLFESGLRFVGQLEGLK---------------------------QEAMLAGAICGKRLPEGWANGRDGVDFFDAKADVEAVLASAGALG-DFSFVPGEHPALHPGQTARIEREGR--LVGYLGALHPELAKKLDLEQPV-FLFELLLAEVVD---------------------------GHLPKFRELSRFPEVRRDLALLVDQD-VPAQDILTQIRAAAGEWLTDLRLFDVYHGKDPHRKSLAVGLTWQHPSRTLNDDEVNSTTQNIVTSLEERFNATLR. 791
11 -41.1002rhs_B mol:protein length:800 Phenylalanyl-tRNA synthetase beta chain  ali model follow..  14  453.VNVPSRRKDITIKEDLIEEVARIYGYDEIPSS--LPVFGEVTSGELTDRQHKTRTLKETLEGAGLNQAITYSLVSKDHAKDFALQERPTISLLMPM------SEAHATLRQSLLPHLIEATAYNVARKNKDVRLYEIGRVFFGNGEGEL-------------------------PDEVEYLSGILTGEYVVNAWQGKKEEIDFFIAKGVVDRVAEKL---NLEFSYKAGKIEGLHPGRTAIVSLGGA--GIGFIGELHPQVAADNDLKR--TYVFELNYDAMMQVA-------------------------VGYINYEQIPKFPGVTRDIALEVNHD-VPSSELKQIIHNNGEDILQSTLVFDVYEGEHKGKKSVAIRLNYLDTEDTLTDERVSKIHDKILEAL-QAQGATIR. 800
12 -38.8001b70_B mol:protein length:785 PHENYLALANYL-TRNA SYNTHETASE  ali model follow..  18  444.VTPPSHRLDLRLEEDLVEEVARIQGYETIPLA-LPAFFPAPDNRGVEAPYRKEQRLREVLSGLGFQEVYTYSFMDPEDARRF-----RLDPPRLLLLNPL--APEKAALRTHLFPGLVRVLKENLDLDRPEALLFEVGRVFREREETHL---------------------------------AGLLFGEGVGLPWAKERLSGYFLLKGYLEALFARLG---LAFRVEAQAFPFLHPGVSGRVLVEGE--EVGFLGALHPEIAQELELPP--VHLFELRLPLPD-----------------------------KPLAFQDPSRHPAAFRDLAVVVPAP-TPYGEVEALVREAAGPYLESLALFDLYQGPPEGHKSLAFHLRFRHPKRTLRDEEVEEAVSRVAEAL-RARGFGLR. 780
13 -34.3004q6g_A mol:protein length:267 Pyrrolysine--tRNA ligase  ali model follow..  15  1.PALTKSQTDRLEVLLNPKDEISLNSGKPFRELESELLSRRKKEERENYLGKLEREITRFFVDRGFLEIKSPILI----------PLEYIERMGIDNDTELSKQIFRVCLRPMVAPNIFNYARKLDRALPDPIKIFEIGPCYRKESDGKEHLEEFTMLNFFQM-----------------------------------GSGCTRENLESIITDFLNHLGIDFKIV--GDSCSVYGDTLDVMH-----GDLELSSAVVGPIPLDREWGIDKP-WIGAGFGLERLLKVKHDFKNIKRAARSESYY................................................................................................................ 260
14 -32.4005k1p_A mol:protein length:274 Pyrrolysine--tRNA ligase  ali model follow..  14  1MPALTKSQTDRLEVLLNPKDEISLNSGKPFRELESELLSRRKKEERENYLGKLEREITRFFVDRGFLEIKSPILIPLEYIERMGIDNDT------ELSKQIFRVDKNFCLRPMLAPNLYNYLRKLDRALPDPIKIFEIGPCYRKESDGKEHLEEFTMLAFAQM-----------------------------------GSGCTRENLESIITDFLNHLGIDFKIV--GDSCMVYGDTLDVMH-----GDLELSSAVVGPIPLDREWGIDKP-WIGAGFGLERLLKVKHDFKNIKRAARSESYY................................................................................................................ 261
15 -31.8003ig2_A mol:protein length:213 Phenylalanyl-tRNA synthetase beta chain  ali model follow..  1............................................SNADKSNKLQNLVAEQLVGCGFNEILNNSLTRAAYYDGLESY----SKNLVMLLNPL--SADLNCMRQTLLFGGLESIAHNANRKNADLKFFEFGNCYHFDAEKKNPEKVLAPYS------------------EDYHLGLWVTGKMVSNSWAHADENTSVYELKAYVENIFKRLGLDLHSL-VVGNLSDDIYSTALTVNTKGGK--RLATFGVVTKKMLKAFDVDNEV-YYADLNWKELM................................................................................................................................... 213
16 -31.6003ica_A mol:protein length:213 Phenylalanyl-tRNA synthetase beta chain  ali model follow..  1............................................SNADRRYKWQTVVSEQLVGAGFNEILNNSLTAGSYYEGLKSH----REMAVELMNPL--SQELNCMRQTLLFGGLETLSHNLRRKHLSLYLFEWGKCYRFHAAKRTDETPLAAYA------------------EDDRLGIWICGQRVHNSWAHPEEPTSVFELKAVVEQVLCRVGIETGAYT-LKTADNDLYASAMEVKTRSGK--LLGTFGTVSTELIKRFEIEQPV-YFAELLWDALM................................................................................................................................... 213
17 -29.3004tqd_A mol:protein length:291 Pyrrolysine--tRNA ligase  ali model follow..  13  33LNPKDEISLNSGKPFRELESELLSRRKKDLQQI--------YAEERENYLGKLEREITRFFVDRGFLEIKSPILIPLEYIERMGIDNDT------ELSKQIFRVDKNFCLRPMLAPNLYNYLRKLDRALPDPIKIFEIGPCYRKESDGKEHLEEFTMLSFIQM-----------------------------------GSGCTRENLESIITDFLNHLGIDFKIVG--DSCMVYGDT-----LDVMHGDLELSSAVVGPIPLDREWGIDKP-WIGAGFGLERLLKVKHDFKNIKRAARSESYY................................................................................................................ 278
18 -27.7003l4g_B mol:protein length:589 Phenylalanyl-tRNA synthetase beta chain  ali model follow..  10  349.IEIPPTRADIIHACDIVEDAAIAYGYNNIQMTLPKT----YTIANQFPLNKLTELLRHDMAAAGFTEALTFALCSQEDIADKLGVDISATKA-VHISNPK--TAEFQVARTTLLPGLLKTIAANRKMPL-PLKLFEISDIVIKDSNTDVGAKNYRHLCAVYY-----------------------------------NKNPGFEIIHGLLDRIMQLLDVPKGGYVIKASEGPAFFPGRCAEIFARGQ--SVGKLGVLHPDVITKFELTMPC-SSLEINIGPFL................................................................................................................................... 589
19 -23.3002e3c_A mol:protein length:291 Pyrrolysyl-tRNA synthetase  ali model follow..  13  33LNPKDEISLNSGKPFRELESELLSRRKKDLQQI--------YAEERENYLGKLEREITRFFVDRGFLEIKSPILIPLEYIERMGIDNDT------ELSKQIFRVDKNFCLRPMLAPNLYNYLRKLDRALPDPIKIFEIGPCYRKESDGKEHLEEFTMLNFCQM-----------------------------------GSGCTRENLESIITDFLNHLGIDFKIV--GDSCMVYGDT-----LDVMHGDLELSSAVVGPIPLDREWGIDKPW-IGAGFGLERLLKVKHDFKNIKRAARSGSYY................................................................................................................ 278
20 -19.6004cs2_A mol:protein length:274 PYRROLYSINE--TRNA LIGASE  ali model follow..  14  1MPALTKSQTDRLEVLLNPKDEISLNSGKPFRELESELLSRRKKEERENYLGKLEREITRFFVDRGFLEIKSPILIPLEYIERMGIDNDT------ELSKQIFRVDKNFCLRPMLAPNLANYLRKLDRALPDPIKIFEIGPCYRKESDGKEHLEEFTMLNFCQM-----------------------------------GSGCTRENLESIITDFLNHLGIDFKIV--GDSCMVFGDT-----LDVMHGDLELSSAVVGPIPLDREWGIDKPW-IGAGFGLERLLKVKHDFKNIKRAARSESYY................................................................................................................ 261
21 -18.6003qtc_A mol:protein length:290 Pyrrolysyl-tRNA synthetase  ali model follow..  13  15APALTKSQTDRLEVLLNPKDEISLNSGKPFRELESELLSRRKKEERENYLGKLEREITRFFVDRGFLEIKSPILIPLEYIERMGIDNDT------ELSKQIFRVDKNFCLRPMLTPNLYNYLRKLDRALPDPIKIFEIGPCYRKESDGKEHLEEFTMLVFWQM-----------------------------------GSGCTRENLESIITDFLNHLGIDFKIV--GDSCMVFGDT-----LDVMHGDLELSSALVGPIPLDREWGIDKPW-IGAGFGLERLLKVKHDFKNIKRAARSESYY................................................................................................................ 275
22 -17.9004bw9_A mol:protein length:291 PYRROLYSINE--TRNA LIGASE  ali model follow..  14  33LNPKDEISLNSGKPFRELESELLSRRKKDLQQI--------YAEERENYLGKLEREITRFFVDRGFLEIKSPILIPLEYIERMGIDNDT------ELSKQIFRVDKNFCLRPMLAPNLGNYLRKLDRALPDPIKIFEIGPCYRKESDGKEHLEEFTMLNFCQM-----------------------------------GSGCTRENLESIITDFLNHLGID---KIVGDSCMVFGDT-----LDVMHGDLELSSAVVGPRPLDREWGIDKPW-IGAGFGLERLLKVKHDFKNIKRAARSES.................................................................................................................. 276
23 -15.2002zni_A mol:protein length:308 Pyrrolysyl-tRNA synthetase  ali model follow..  15  58........................RAFQGIEHQLMSQGKRHLTVKHRPALLELEEKLAKALHQQGFVQVVTPTIITKSALAKMTIGEDH------PLFSQVFWLDGKKCLRPMLAPNLYTLWRELERLWDKPIRIFEIGTCYRKESQGAQHLNEFTMLNLTELGTPLEERHQR---------------------------------LEDMARWVLEAAGIREFELVTESSVV------YGDTVDVMKGDLELASGAMGPHFLDEKWEIFDP-WVGLGFGLERLLMIREGTQHVQSM....................................................................................................................... 287

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Friedberg I. and Godzik A Connecting the Protein Structure Universe by Using Sparse Recurring Fragments. Structure (Camb.) (2005) Aug;13(8):1213-24