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Query: 4tqd_A mol:protein length:291 Pyrrolysine--tRNA ligase, from PDB1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MGSSSSGLVPRGSHMASAPALTKSQTDRLEVLLNPKDEISLNSGKPFRELESELLSRRKKDLQQIYAEERENYLGKLEREITRFFVDRGFLEIKSPILIPLEYIERMGIDNDTELSKQIFRVDKNFCLRPMLAPNLYNYLRKLDRALPDPIKIFEIGPCYRKESDGKEHLEEFTMLSFIQMGSGCTRENLESIITDFLNHLGIDFKIVGDSCMVYGDTLDVMHGDLELSSAVVGPIPLDREWGIDKPWIGAGFGLERLLKVKHDFKNIKRAARSESYYNGISTNLLast
1 -58.000[J] KOG2784 Phenylalanyl-tRNA synthetase, beta subunit  ali follow..  16  256.GSWKDMQFKKYNFDSLGVVPSSGHLHPLMKVRSEFRQIFFSMG--FSEMTNRYVESSFWNFDALFQPQQHP-----ARDAHDTFFVSDPAISTKFPEDYLERVKTVHSKSAGYNYDWKIEEAQKNVLRTHTTAVSARQLYQLAQEGFRPSKLFSIDRVFRNETLDATHLAEFHQVEGVIAEKNLSLAHLIGIFTEFFKKLGITNLRFKPTYNPYTEPSMEITKWVEIGNSGMFRPEMLLPMGLDVNVAGYGLSLERPTMIKYGINNIRDLFGSKIDL....... 539
2 -54.300[J] COG0016 Phenylalanyl-tRNA synthetase alpha subunit  ali follow..  13  83.EIHRKLQEETIDVTLPGRPVLKGGAHPLTATITEVEDLFIGLG--FSVAEGPQIETDYYNFEALNLPKDHP-----ARDMQDSFY-----------------------------------FTDELLLRTQTSPVQARTMEKYKG--KGPIKIICPGKVFRRDDDDATHSHQFMQIEGLYVDHGVRMSDLKGVLQAFAKSFFGEERRLRPSFFPFTEPSVEVTGWIEILGAGMVHPRVLEMSGFNPNGFAFGMGVERLSMLKYGIDDIRHFYTNDRRF....... 337
3 -49.300[J] COG2024 Phenylalanyl-tRNA synthetase alpha subunit (archaeal type)  ali follow..  16  22.AGKEILAERSPNELYPRVGFSFGKEHPLFATIQRLREAYLSIG--FSEVVNPLIVEDVHVKKQFGREAAITKREVDSKPLQEIFHRYKKGEIDGDDLSY-LIAEVLDVDDITAVFKELKPISSTLTLRSHMTTGWFITLSHIADKLPLPIKLFSIDRCFRREGEDATRLYTYFSASCVLVDEELSVDDGKAVAEALLRQFGFENFRKDEKRSKYYIPDTQTDGWIEIATFGIYSPTALAEYDIPYPVMNLGLGVERLAMILYGYDDVRKMVYPQIHG....... 353
4 -37.000[J] COG1190 Lysyl-tRNA synthetase (class II)  ali follow..  17  114......KKWDLGDILGARGKLFKTKTGELSIHCSELRLLTKALPDKFHGLADQETRYRQRYLDLIANDESRHVRSQVMSGIRSFMVEKGFMEVETPMMQVI-----PGGASARPFVTHHNALDIDMYLR------IAPELYLKRLVVGGFERVFEINRNFRNEGVSPRHNPEFTMMELYMAYAD--YKDLIVLTEELFRTLTEDNPFITDRFEFFIGGREIGNGFSELNDAEDQAQRFADQVSAKPPTAGLGIGIDRMVMLFTNSHTIRDV.............. 495
5 -35.800[J] KOG1885 Lysyl-tRNA synthetase (class II)  ali follow..  17  174......NKLRRGDIIGVQGNPGKTKKGELSIIPYEITLLSPCLPHLHFGLKDKETRYRQRYLDLILNDFVRQIRSKIITYIRSFLDELGFLEIETPMMNII-----PGGAVAKPFITYHNELDMNLYMR------IAPELYHKMLVVGGIDRVYEIGRQFRNEGIDLTHNPEFTTCEFYMAYAD--YHDLMEITEKMVSGMV-SKEGLTERFELFVMKKEICNAYTELNDPMRQRQLFEEQAKAKPPTAGWGMGIDRVAMFLTDSNNIKEV.............. 567
6 -33.200[J] COG2269 Truncated, possibly inactive, lysyl-tRNA synthetase (class II)  ali follow..  15  1.........................MSQLSLAFCSERVQFVSVSCDEPPMTNSDWMPTA-------SISQLKQRATLLRQIREFFAERNVLEVETPAMSHATVTDIHLHTFKTEFVGPGYAKGSALHLMTSPEFHMKRLL------AAGSGCIYQLGKAFRNEENGRYHNPEFTMLEWYRIGFDHHMDEMDALLQLVLRCGSAERMTYQEAFLNVLGVCPLEEEMRELKQVALFSIGIEPKIGQITPAFVYDFPASQAALAKINPADPRVADRFEVYFKGIEL.. 269
7 -31.600[J] KOG2783 Phenylalanyl-tRNA synthetase  ali follow..  11  1..............................MFPHRVSHLSKLFSRRFPNWKRKVQTDSWSNVPEHLFQKEGHPICSLRQLLEQQFQKFEMNNVQKPIVSVETNFDSLGFPKTHVSRSKSDTMNNKTCLRTHTSAHQPEEFSRLAKEGFKKNGFLITADVYRRDEVDSSHYPIFHQMEGALVWNRNDTAKMKNDLKKVALSPSLKSMVDDETTALETHNIDWKGKWLEILGCGVVQDRLLKGAGLNYIGWAFGIGLERLAMILYGIPDIRLFWSLD.......... 320
8 -31.400[J] COG0124 Histidyl-tRNA synthetase  ali follow..  18  1.....................................................MAIQIPRGTQDILPGDVE-TWQWIEQKAYDLCRRYNYQEIRVPMFEHTELFLRGVGDTTKEMYTFEDRGGRSLTLRPEGTASVTRAYVSNKGQANQPTKLFYIGPMFRYERPQSGRMRQFVQFGVEALGSADPAIDAEALVMRFYEELGLKNLKLVINSLGDTDSRLAHREALVLCGGGRYNGLVEEIGGPETPGIGFALSIERAIMALEAQQ................... 321
9 -30.000[J] KOG1936 Histidyl-tRNA synthetase  ali follow..  13  25.......................ASCTGAVRCQSQVAEAVLTSQLKAHQEKPNFIIKTPKGTRDLSPQHMV-VREKILDLVISCFKRHGAKGMDTPAFELKETLTEKYGEDSGLMYDLKDQGGELLSLRYDLTVPFARYLAMNKVK---KMKRYHVGKVWRRESPTQGRYREFCQCDFDIAGQFDPMAECLKIMCEILSGLQLGDFLIKVN.......................................................................... 213
10 -27.400[E] COG3705 ATP phosphoribosyltransferase involved in histidine biosynthesis  ali follow..  11  8...........................................................EHIADVLPTNARQ-LESAREQLLALFRVHGYELVQPPLMEYAHSLLTHIDAGLKTILVTDRLSGRQLGIRADITPQVARIDAHLLSANQGINRLCYAGPVLHAQSDGLLNMREPLQAGAEMYGFADIRGDIEDLMLKSMKIADMGKVLLS............................................................................ 160
11 -26.800[J] KOG0554 Asparaginyl-tRNA synthetase (mitochondrial)  ali follow..  18  158......GSILTGASVSVQGTIVASQGTKQKVELKVEKIIVVGESYPIQKKRVSREFLRTKAHLRPRTNTFGRVRNTLAYATHKFFQESGFVWVASPIITASDSIDAIPKTKGGLIDWSQDFFGKPAFLT--VSGQLNGET-----YATALSDVYTFGPTFRAENSNTSHLAEFWMIEPELAFAD--LDDDMACATAYLQYV-SDVAEKEFLQLGYTDAIEILLK--ELIGGSQREERLEVRYGS-VPHAGFGLGFERLVQFVTGIDNIRDV.............. 555
12 -26.000[J] KOG0556 Aspartyl-tRNA synthetase  ali follow..  16  155......GSISLESIVLVEGIVKKSPEQDAEIHISSIYVISPIKKDSKFVRVNLDTRLDNRVLDLRTPTAIFDIQAGICQAFREFLLSNSFNEIHTPKMSGAS-----SEGGSNVFK--IQYFKTDGFLS------QSPQLYKQMLIAADRERVFEIGPVFRAEDSNTYHMTEFTGLDLEMAFNE-HYHEVMEFIEKLFLYI--EDPRYSNSYDFFMKGQEIMSGAQRIHDPELLVERMKAAIGC-PPHAGGGIGLERVVMFYLNLPNIRLA.............. 568
13 -26.000[J] COG0173 Aspartyl-tRNA synthetase  ali follow..  12  61......DSSRNEYVLSITGRVRNRISGKIEILAKEIEVLNAAATPPFDENISENVRLTNRVIDLRRPVRNLRLRYQVAMGVRRYLDAQGFIDIETPML-----TRSTPEGARDYLVPSRVHPGEFFALP------QSPQLFKQLLMVAGFDRYYQITKCFRDEDLRADRQPEFTQIDLETSFLN--EDEIMDITEGMAKQV-----------------FKDALNVDLGDFPRMPYSEAMFYYGSDKPDMRINLKFTELTDLMKTEE................... 304
14 -23.500[J] KOG2411 Aspartyl-tRNA synthetase, mitochondrial  ali follow..  15  2...................................................................QYNLRLRSQMVMKMREYLNLHGFVDIETPTL------FKRTPGGAKEFLVPSREPGKFCSLP------QSPQQFKQLLMVGGLDRYFQVARCYRDEGSRPDRQPEFTQIDIEMSFVD--QTGIQSLIEGLLQYS-----------------WPNDKDPVVVPFPTMTFAEVLATYGTDKPDTRFGMKIIDISDVFRNTE................... 170
15 -23.400[J] COG0017 Aspartyl/asparaginyl-tRNA synthetases  ali follow..  18  61......KEIAQESSLYVTGTITEDNRSDYEMQVKSIEVISEAHDTPKNHGTEFLMDHRHLWLRSKKQHAVMKIRNEVIRATYEFFNKDGFTKVDPPILTASA-----PEGTSELFHTKYFDQDAFLSQSGQL---------YLEAAAMAHGKVFSFGPTFRAEKSKTRHLIEFWMIEGEMAFTN--HAESLEIQEQYVTHVVKSVLENCKLRISYDDAIEFLKGYGEIIGGSERVDDLEKEHGLDEEAYGFGLGLERTVAWISGVEHVRET.............. 418
16 -22.800[J] KOG0555 Asparaginyl-tRNA synthetase  ali follow..  13  161CQSYDAVTLSTETSVQVYGIIKALPDGKHELTVDYWEVIGKAPAGVLNESAGVDVMLDNRHLVIRGENRILRIRAAATRAMRDHFFAAGYTEVAPPTLVQTQ-----VEGGSTLFGLDYYGEPAYLTQSSQL---------YLETCNAALGDVYCISQSYRAEKSRTRHLSEYQHVEAECAFIT--FDQLMDRIEALVCDTVDRYMPRCADDNELTESVDLLMPGVEIVGGSMRIWKEDEKGGLDSKNYGYGLGLERFICWLTDTNHIRDV.............. 533
17 -20.500[J] KOG2472 Phenylalanyl-tRNA synthetase beta subunit  ali follow..  13  319IGEQVTSLLTRMQLQAEQAKSSDNQ----CAIKVHVPPSRSDVLHPCDVMEDVAIAYGFNNIPTRKPASIKPTLNELTDLLRIEIAMCVYTEVVTLLCSHKENFAMLNREDVNSAVIVGNPRSADFAMRRALMPGLLKTVGHNNKY-PKPIKIFEISDVVMLDESKDVGASNRRHLAALYCGATSGFELIHGLVDRIMEVMAIPFLTIHENNVPIGRQASIIVRGKHIGNFGIVHPEVLNNFDIPDPCSYLELDIEAIL.......................... 598
18 -17.700[J] KOG2324 Prolyl-tRNA synthetase  ali follow..  15  2....................LQHLRNRASIEVLGKAIRKYNVPESANQLLIDMGFIQPSMPGIFQYLPLGLRVQNKICDLLHISMRSLGASAISLAHLSSKEIWEKSGQKTGSELFRLHDRNDREMCLAPTHEEDVTRTMATIIDSQKQPIRVYQIGRKFRDELRPRGRGREFMMKDLYTFDIDKTYEDVLQAYHTFFKEVGLPFVMVKAATGNIGGNLSTSTTAIEVGHAFYLGKIYSSKFNATVEVKNYGIGVSRLIAAVAHVTKDAKGLVWPSSIAPWKVLV 333
19 -16.800[E] COG2502 Asparagine synthetase A  ali follow..  14  7....................................................................LQQQEISFVKNTFTQNLIEQGIIEVQGPILSQVGNGMQDNLSGIEKAVQVNVKCIPNAVFEVVHSLAKWKRHTLARFNFKEDEGLFVHMKALRPDSLDPTHSVYVDQWDWEKVEGRRNFAYLKETVNSIYRAIGKPHDGRAPDYDDWTTESDQLGKAFELSSMGVDESALRLQVGLTPLTIGGGIGQSRLAMLLLRKKHIGEVQSS........... 316
20 -15.800[J] COG0442 Prolyl-tRNA synthetase  ali follow..  17  27.................................................LRAGMIRKLASGLYTWLPTGVR-VLKKVENIVREEMNNAGAIEVSMPVVQPADLWQESGEQYGPELLRFVDRGERPFVLGPTHEEVITDLIRGEINSYKQPLNFFQIQTKFRDEVRPRFRAREFLMKDAYSFHTTQTYDAMYTAYSKIFSRMDLNFRAVLAD.......................................................................... 198
21 -14.700[J] COG0752 Glycyl-tRNA synthetase, alpha subunit  ali follow..  12  2....................................................................SKKLTFQEIILTLQQFWNDQDCMLMQAYDNE--------------------------------KGAGTMSPYTFLRAIGPEPWNAAYVEPSRRADGRYGENPNRLYQHHQFQVVMKPSPSNIQELYLESLEKLGIEDNWENPSTGSAGLGWEVWLDGMEITQFTYFQ--QVGGLATGPVTAEVTYGLERLASYIQEVDSVYDI.............. 181
22 -13.800[J] COG0072 Phenylalanyl-tRNA synthetase beta subunit  ali follow..  10  278IGHHIADE-QVTDILRRLGCEVTEGKDEWQAVAPSWRFDMEIEEDLVEEVA------RVYGYNNILIMGTHREADLSLKRVKTLLNDKGYQEVITYSFVDPKVQQMIHPGVEALLLPSPISVEMSA-MRLSLWTGLLATVVYNQNRQQNRVRIFESGLRFVPDTQAPLGIRQDLMLAGVICGETVDFYDLKGDLESVLDLTGKLNEVEANPALHPGQSAAIYLKGERIGFVGVVHPELERKLDLNGRTLVFELEWNKLADRVVPRRDIAVVVAENVPAADILSEC 588
23 -13.600[J] KOG4163 Prolyl-tRNA synthetase  ali follow..  11  155....EGKKQQKKQQPSKAGTAAAAAAAALE--DAKLIGITVDKALDFPGWYQQILTKGEM----ILRPPSYAIWENIQKWFDDKIKAIGVQNAYFPMFVSSRVLEKEKDHVEG--RAGSSELEEPIAIRPTSETVMYPYYAKWVQSYRDPLKLNQWNSVVRWEFKHPQRTREFLWQEGHTAHLTAKDAEILDFYAGVYEELLA.................................................................................. 373
24 -11.100[J] COG0172 Seryl-tRNA synthetase  ali follow..  16  182................................................................................MDLHHDKHGYEEVLPPYLVNRTSMTGTGQLPKFEEDAFKIREEDYFLIPTAEVPVTNLHRDEILSADQLPIAYTAYSMNFRSEAGSAGRQHQFNKVELVRFDSYDELEKLTGHAEKVLQLLKLPYRVMSMCTADLGFTAAKKNTYREISSCSNFEDFQARRANIKFR--GSGLAVGRTVAA........................ 395
25 -10.500[J] KOG2509 Seryl-tRNA synthetase  ali follow..  15  195................................................................FLKGVLVFLEQALIQYALRTLGSRGYIPIYTPFFMRKEVMQEVA--IGKGSEKSDDNSYDEKYLIATSEQPIAALHRDEWLRPEDPIKYAGLSTCFRQEVGSHGRVHQFEKIEQFVYKSWEMFEEMITTAEEFYQSLGIPYHIVNIVSGSLNHAASKKGAFRELVSCSNCTDYQARRLRIRYG--ATMCATTRTICA---------ILENYQTEKGITV.. 452
26 -10.300[J] COG0441 Threonyl-tRNA synthetase  ali follow..  17  189....NMRFCHHFKLMKTAGAYWRGDSN--NKMLQRIYGTAWADKKALNAYLQRLEEAAKRDHRKIWHNDGWTIFRELEVFVRSKLKEYQYQEVKGPFMMDRVLWEKTG-DNYKDAMFTTSSENREYCIKPMNCPGHVQIFNQGLKSYRDPLRMAEFGSCHRNEPSGSMRVRGFTQDDAHIFCTEEQIRDCIRLVYDMYSTFGFEKIVVKLSTRP....................................................................... 424
27 -9.980[J] KOG1637 Threonyl-tRNA synthetase  ali follow..  17  237....HTGKVKALKITKNSSTYWEGKAD--AETLQRVYGISFPDPKQLKEWEKLQEEAAKRDHRKIFQPRGAHIYNTLMGFIKAEYRKRGFQEVISPNIYNAKLWMTSG-QHYAENMFSFEAEKEKFALKPMNCPGHCLIFDNRNRSWREPLRMADFGVLHRNELSGATRVRRFQQDDAHILGELEQWNDAEKALAESLNEFGMPWKENPGDGAFYGPKIDITIMDARAHQCATIQLDFQLPIRFNLSYIADDGEKKRPVIIHRAI.................... 561

FFAS is supported by the NIH grant R01-GM087218-01
1 2 7 7 6 3   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Awobuluyi M, Yang J, Ye Y, Chatterton JE, Godzik A, Lipton SA, Zhang D. Subunit-specific roles of glycine-binding domains in activation of NR1/NR3N-methyl-D-aspartate receptors. Mol Pharmacol. 2007 Jan;71(1):112-22. Epub 2006 Oct 17.