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Query: 2el9_A mol:protein length:431 Histidyl-tRNA synthetase, from PDB1018

Results of FFAS03 search in H.sapiens
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst GPGYQDPMAKNIQAIRGMNDYLPGETAIWQRIEGTLKNVLGSYGYSEIRLPIVEQTPLFKRAIGEVTDVVEKEMYTFEDRNGDSLTLRPEGTAGCVRAGIEHGLLYNQEQRLWYIGPMFRHERPQKGRYRQFHQLGCEVFGLQGPDIDAELIMLTARWWRALGISEHVTLELNSIGSLEARANYRDALVAFLEQHKEKLDEDCKRRMYTNPLRVLDSKNPEVQALLNDAPALGDYLDEESREHFAGLCKLLESAGIAYTVNQRLVRGLDYYNRTVFEWVTNSLGSQGTVCAGGRYDGLVEQLGGRATPAVGFAMGLERLVLLVQAVNPEFKADPVVDIYLVASGADTQSAAMALAERLRDELPGVKLMTNHGGGNFKKQFARADKWGARVAVVLGESEVANGTAVVKDLRSGEQTAVAQDSVAAHLRTLLGLast
1 -99.100sp|P49590|SYHM_HUMAN(removed signalp:1-13) Probable histidyl-tRNA synthetase, mitochondrial OS=Homo sapiens GN=HARS2 PE=1 SV=1  ali follow..  21  35..AHQEKPNFIIKTPKGTRDLSPQHMVVREKILDLVISCFKRHGAKGMDTPAFELKETLTEKYGEDS----GLMYDLKDQGGELLSLRYDLTVPFARYLAMNK---VKKMKRYHVGKVWRRESPTQGRYREFCQCDFDIAGQFDPMPDAECLKIMCEILSGLQL-GDFLIKVNDRRIVDGMFAVCGVPESKFRAICSSIDKLDKMAWKDGDYVQCHGGVSLVEQMFQDPRLSQNKQALEGLGDLKLLFEYLTLFGIKISFDLSLARGLDYYTGVIYEAVLLQTPTQGSVAAGGRYDGLVGMFDPKKVPCVGLSIGVERIFYIVEQRMKTKGRTTETQVFVATPQKNFLQERLKLIAELWD--SGIKAEMLYNNPKLLTQLHYCESTGIPLVVIIGEQELKEGVIKIRSVASREEVAIKRENFVAEIQKRLS 491
2 -95.500sp|P12081|SYHC_HUMAN Histidyl-tRNA synthetase, cytoplasmic OS=Homo sapiens GN=HARS PE=1 SV=2  ali follow..  22  47..PDESKQKFVLKTPKGTRDYSPRQMAVREKVFDVIIRCFKRHGAEVIDTPVFELKETLMGKYGEDS----KLIYDLKDQGGELLSLRYDLTVPFARYLAMNKL---TNIKRYHIAKVYRRDNPTRGRYREFYQCDFDIAGNFDPMPDAECLKIMCEILSSLQI-GDFLVKVNDRRILDGMFAICGVSDSKFRTICSSVDKLDKVSWEEVADRIGDGGVSLVEQLLQDPKLSQNKQALEGLGDLKLLFEYLTLFGIDISFDLSLARGLDYYTGVIYEAVLLQTPAQGSVAAGGRYDGLVGMFDPRKVPCVGLSIGVERIFSIVEQRLEALEETTETQVLVASAQKKLLEERLKLVSELWD--AGIKAELLYKNPKLLNQLQYCEEAGIPLVAIIGEQELKDGVIKLRSVTSREEVDVRREDLVEEIKRRTG 503
3 -45.400sp|Q9P2K8|E2AK4_HUMAN Eukaryotic translation initiation factor 2-alpha kinase 4 OS=Homo sapiens GN=EIF2AK4 PE=1 SV=3 (Range: 1051-1350)  ali follow..  14  2..............LKG--NFSIRTAKMQQHVCETIIRIFKRHGAVQLCTPLLLPRNRQIYEHNEA--------ALFMDHSGMLVMLPFDLRIPFARYVARNNI---LNLKRYCIERVFRPRKLDRFHPKELLECAFDIVTTNSFLPTAEIIYTIYEIIQEFPAERNYSIYLNHTMLLKAILLHCGIPEDKLSQVYIILYDAVTEKLTRREVEAKFCNLSLSSNSLCRLYKFIEQLVKYGLKDLEEVVGLLKKLGIQVLINLGLVYKVQQHNGIIFQFVAFIKRRQEILAAGG.......................................................................................................................................... 300
4 -44.800sp|Q9P2K8|E2AK4_HUMAN Eukaryotic translation initiation factor 2-alpha kinase 4 OS=Homo sapiens GN=EIF2AK4 PE=1 SV=3 (Range: 1201-1500)  ali follow..  16  4........................................................................................................................................................MLLKAILLHCGIPED---KLSQVYIILYDAVTEKLTRREVEAKFCNLSLSSNSLCRLYKFIEQKGDLQDLMPTINSLKTGIAQLVKYGLKDLEEVVGLLKKLGIKVLINLGLVYKVQQHNGIIFQFVARQRAVPEILAAGGRYDLLIPQFRGPQPTAIGVSIAIDKISAAVLNMEESVT-ISSCDLLVVSVGQMSMSRAINLTQKLWT--AGITAEIMYDSQSQEELQEYCRHHEITYVALVSDKEGSHVKVKSFEKERQTEKRVLETELVDHVLQKLR 291
5 -27.100sp|Q9P2K8|E2AK4_HUMAN Eukaryotic translation initiation factor 2-alpha kinase 4 OS=Homo sapiens GN=EIF2AK4 PE=1 SV=3 (Range: 1351-1649)  ali follow..  15  1.....................................................................................................................................................................................................................................................................................................RYDLLIPQFRGPQALAIGVSIAIDKISAAVLNMEESVT-ISSCDLLVVSVGQMSMSRAINLTQKLWT--AGITAEIMYDSQSQEELQEYCRHHEITYVALVSDKEGSHVKVKSFEKERQTEKRVLETELVDHVLQKLR 141
6 -26.600sp|Q7L3T8|SYPM_HUMAN Probable prolyl-tRNA synthetase, mitochondrial OS=Homo sapiens GN=PARS2 PE=1 SV=1  ali follow..  14  82............PASPGCYHLLPYTVRAMEKLVRVIDQEMQAIGGQKVNMPSLSPAELWQAT--NRWDLMGKELLRLRDRHGKEYCLGPTHEEAITALIASQLSYKQLPFLLYQVTRKFRDERPRFGRGREFYMKDMYTFDSSPEAAQQTVCDAYCSLFNKLGLP--FVKVQADVGTIGGTVSHEFQLPVDIGEDRLAICPRCSFSANMETLDLSQMNCPACQGPLTKTKGI--------------------EVGHTFYLGTKYSSIFN---------------------------QFTNVCGKPTLAEMGYGLGVTRILAAAIEV-RWPSLLAPYQACLIPPKKGSKEQAAQLYDHITEAVPQLHGEVLLDDRTIGNRLKDANKFGYPFVIIAGKRALEDAHFEVWCQNTGEVAFLTKDGVMDLLTPV.. 472
7 -18.500sp|Q9P2K8|E2AK4_HUMAN Eukaryotic translation initiation factor 2-alpha kinase 4 OS=Homo sapiens GN=EIF2AK4 PE=1 SV=3 (Range: 901-1200)  ali follow..  11  158......................IRTAKMQQHVCETIIRIFKRHGAVQLCTPLLLPRNRQIYEHNEAALFM--------DHSGMLVMLPFDLRIPFARYVARNNILN---LKRYCIERVFRPRKLDRFHPKELLECAFDIVTTNSFLPTAEIIYTIYEIIQEFPALQERNYSIY.................................................................................................................................................................................................................................................................. 299
8 -16.500sp|P07814|SYEP_HUMAN Bifunctional aminoacyl-tRNA synthetase OS=Homo sapiens GN=EPRS PE=1 SV=5 (Range: 901-1200)  ali follow..  15  139..........EYHDISGCYILRPWAYAIWEAIKDFFDAEIKKLGVENCYFPMFVSQSALEKE-KTHVADFAPEVAWVTRSGAEPIAIRPTSETVMYPAYAKWQSHRDLPIKLNQWCNVVRWEKHPQPRTREFLWQEGHSAFATMEEAAEEILDLYAQVYEEL............................................................................................................................................................................................................................................................................. 300
9 -14.300sp|P41250|SYG_HUMAN(removed signalp:1-26) Glycyl-tRNA synthetase OS=Homo sapiens GN=GARS PE=1 SV=3 (Range: 451-713)  ali follow..  18  102........................................................................................................................................................................................................................................................................................................................SFGLGRIMYTVFEHTFHVREGDKCSVLPLSQNQEFMPFVKELSEALTRH--GVSHKVDDSSGSIGRRYARTDEIGVAFGVTIDFDTVNKTTATLRDRDSMRQIRAEISELPSIVQDLAN 235
10 -13.800sp|A2RTX5|SYTC2_HUMAN Probable threonyl-tRNA synthetase 2, cytoplasmic OS=Homo sapiens GN=TARSL2 PE=1 SV=1 (Range: 601-802)  ali follow..  13  2..........................................................................................................................................................................................................................................................LMDFGEPWKMNP----GDGAFYGPKIDIKIKDAIGRYHQCATIQLDQLPIRFNLTYVSKDG---SVERMIAILSENGKWPFWLSPRQVMVIPVGPTCEKYALQVSSEFFEEGFMADVDLD-HSCTLNKKIRNAQLAQYNFILVVGEKEKIDNAVNVRTRDNKIHGEILVTSAIDKLKNLRK 192
11 -13.500sp|P07814|SYEP_HUMAN Bifunctional aminoacyl-tRNA synthetase OS=Homo sapiens GN=EPRS PE=1 SV=5 (Range: 1051-1350)  ali follow..  14  1......................PWAYAIWEAIKDFFDAEIKKLGVENCYFPMFVSQSALEKEKTH--ADFAPEVAWVTRSGKTEIAIRPTSETVMYPAYAKWQSHRDLPIKLNQWCNVVRWEKHPQPRTREFLWQEGHSAFATMEEAAEEILDLYAQVYEELLAI.......................................................................................................................................................................................................................................................................... 153
12 -12.700sp|Q96I59|SYNM_HUMAN(removed signalp:1-16) Probable asparaginyl-tRNA synthetase, mitochondrial OS=Homo sapiens GN=NARS2 PE=1 SV=3  ali follow..  15  118...HPLEYLRQYPHFRCRTNVLGSILRIRSEATAAIHSFFKDSGFVHIHTPIITSNELFQLEPSGKLKVPEENFF----NVPAFLTVSGQLHLEVMSGAFT---------QVFTFGPTFRAENSQSRRHAEFYMIEAEISFVDS-----DLMQVIEELFKATMVLSKCPEDVELCH--------KFIAPGQKDRLEHMLKNNFLIISYTEAVEILKQASQNFTFTPEWGADLRTEHEKYLVKHCGNIPVFVINYPLTLK-PQHTVAAVDLLVPGVGELFGGGLREE-------RYHFLEERLARSGLPHGGFGMGFERYLQCI............................................................................................................ 440
13 -12.100sp|P26639|SYTC_HUMAN Threonyl-tRNA synthetase, cytoplasmic OS=Homo sapiens GN=TARS PE=1 SV=3 (Range: 451-723)  ali follow..  14  4...............................................................................................................................RVRRFQQDDAHIFCAMEQIEDKGCLDFLRTVYSVFGFSFKLNLSTRPLGDIEVWDQAEKQLENSLNEFGEKWELNSGDGAFYGPK--IDIQIKDAIGRYHQCATIQLDFQLPIRFNLTYVSHDGDDKKRPVIVHRAILGSVERMIAILTENY------------GGKWPFWLS----------------------------------PRQVMVVPVGPTCDEYAQKVRQQFHDAKFMADIDLD-PGCTLNKKIRNAQLAQYNFILVVGEKEKISGTVNIRTRDNKVHGERTISETIERLQQLKE 263
14 -12.000sp|A2RTX5|SYTC2_HUMAN Probable threonyl-tRNA synthetase 2, cytoplasmic OS=Homo sapiens GN=TARSL2 PE=1 SV=1 (Range: 301-600)  ali follow..  16  106..GKEQELFFFHDLSPGSCFFLPRGAFIYNTLTDFIREEYHKRDFTEVLSPNMYNSKLWEAS--GHWQHYSENMFTF-EIEKDTFALKPMNCPGHCLMFAHRRSWREMPIRFADFGVLHRNELSGT-RVRRFQQDDAHIFCTVEQIEEKGCLQFLQSVYSTFGFSFQLNLSTNFLGEIEMWNEAEKQLQN................................................................................................................................................................................................................................................. 300
15 -11.600sp|Q9BW92|SYTM_HUMAN Threonyl-tRNA synthetase, mitochondrial OS=Homo sapiens GN=TARS2 PE=1 SV=1 (Range: 451-718)  ali follow..  14  2.................................................................................................................................RCFQQDDAHIFCTTDQLEAQSCLDFLRSVYAVLGFSFRLALSTRPSGFLGDPCLWDQA---------------------------------------------------------QVLKQALKEFGEPWDLNS----GDGAFYGPKIDVHLHDALGRPHQCGTIQLDQYKGQAGALERPVLAVLGSVERLLGVLAESGKWPLWLSPFQVVVIPVGSEQEEYAKEAQQSLRAAGLVSDLDAD-SGLTLSRRIRRAQLAHYNFQFVVGQKEQSKRTVNIRTRDNRRLGEWDLPEAVQRLVELQN 258
16 -11.400sp|P14868|SYDC_HUMAN Aspartyl-tRNA synthetase, cytoplasmic OS=Homo sapiens GN=DARS PE=1 SV=2  ali follow..  17  196.........................FRLQSGICHLFRETLINKGFVEIQTPKIISAASEGGANVFTVSYFKNNAY---------LAQSPQL---YKQMCICADFE-----KVFSIGPVFRAEDSNTHRH-EFVGLDIEMAFNYH-----EVMEEIADTMVQIGLQERFQTEIQTVNKQFPCEPFKFLEPTLRLEYCEALAMLREAGVEMGDEDDLSTPNEK---------LLGHLVKEKYDTDFYILDKYPLAVRPFYTMNPKQSNSYDMFMR-------------EEILSGAQIKAYIDSFRFGAPPHAGGGIGLERVTMLF............................................................................................................ 480
17 -11.400sp|O43776|SYNC_HUMAN Asparaginyl-tRNA synthetase, cytoplasmic OS=Homo sapiens GN=NARS PE=1 SV=1  ali follow..  14  246.........................LKARSMVTRCFRDHFFDRGYYEVTPPTLVQTQVEGGATLFKLDYFGEEAF---------LTQSSQLYLETCLPALG---------DVFCIAQSYRAEQSRTRRHAEYTHVEAECPFLT------DLLNRLEDLVCDVRILKSPAGSIVHELNPNFQPPKRPFKRMNYSDAIVWLKEHDVKKEDGTFYEDIPEAPERLMTDTINEPILLCRFPVEIKSFYMQRCP-----------DSRLTESVDVLMPNVGE-----------IVGGSMYYWYTDQRKYGTCPHGGYGLGLERFLTWI............................................................................................................ 527
18 -11.100sp|Q9BW92|SYTM_HUMAN Threonyl-tRNA synthetase, mitochondrial OS=Homo sapiens GN=TARS2 PE=1 SV=1 (Range: 301-600)  ali follow..  15  6..GKEQELFFFHELSPGSCFFLPRGTRVYNALVAFIRAEYAHRGFSEVKTPTLFSTKLWEQS--GHWEHYQEDMFAVQPPGTDTLALKPMNCPAHCLMFAHRRSWRELPLRLADFGALHRAEASGG-RLRCFQQDDAHIFCTTDQLEAQSCLDFLRSVYAVLGFSFRLALSTRPSGFLGDPCLWDQA---------------------------------------------------------QVLKQALKEFGEPWDLNS----GDGAFYGPKIDVHLHDALGRPHQCGTIQLDQYKGQAGALERPVLAVLGSVERLLGVL............................................................................................................ 299
19 -11.000sp|P26639|SYTC_HUMAN Threonyl-tRNA synthetase, cytoplasmic OS=Homo sapiens GN=TARS PE=1 SV=3 (Range: 301-600)  ali follow..  14  27..GRDQELYFFHELSPGSCFFLPKGAYIYNALIEFIRSEYRKRGFQEVVTPNIFNSRLWMTS--GHWQHYSENMFSF-EVEKELFALKPMNCPGHCLMFDHRRSWRELPLRLADFGVLHRNELSGA-RVRRFQQDDAHIFCAMEQIEDKGCLDFLRTVYSVFGFSFKLNLSTRPLGDIEVWDQAEKQLENSLNEFGEKWELNSGDGAFYGPK--IDIQIKDAIGRYHQCATIQLDFQLPIRFNLTYVSHDGDDKKRPVIVHRAILGSVE.................................................................................................................................................................. 298
20 -10.100sp|Q9UHN1|DPOG2_HUMAN DNA polymerase subunit gamma-2, mitochondrial OS=Homo sapiens GN=POLG2 PE=1 SV=1  ali follow..  11  94...............GCHPGFGPLGVELRKNLAAEWWTVVFREQVFPVDALHHKPGPLLPGDLQDKELSKEQLVAFLENVLKTSGKLRENLLHGALEHYCLDLVNKRLPYGLAQIGVCFHPVFDTK-SIGEKTEASLVWF-------------------------------TPPRTSNQWLDFWLRHRLQWWR----------KFAMSPSNFSSSDCQDEEGRKGNKLIETLWNLGDHELLHMYPGNVSKLHGRDGRKNVVPCVLSVNGDLDRGMLAYLYDSFQLTENSFTRKK--------------------NLHRKVLKLHPC-------APIKVALDVGTLELRQVCQGLFNELLENGISVPGYLETMQSSLEQLYSKYDEMSILFTVLVTETTLENGLIHLRSRDTTMKEMMHISKLKDFLIKYIS 480
21 -9.490sp|A2RTX5|SYTC2_HUMAN Probable threonyl-tRNA synthetase 2, cytoplasmic OS=Homo sapiens GN=TARSL2 PE=1 SV=1 (Range: 451-750)  ali follow..  13  1...............................................VLSPNMYNSKLWEAS--GHWQHYSENMFTFEIE-KDTFALKPMNCPGHCLMFAHRRSWREMPIRFADFGVLHRNELSGT-RVRRFQQDDAHIFCTVEQIEEKGCLQFLQSVYSTFGFSFQLNLSTRPLGEIEMWNEAEKQLQNSLMDFGEPWKMNPGDGAFYGPK--IDIKIKDAIGRYHQCATIQLDFQLPIRFNLTYVSKDGDDKKRPVIIHRAILGSVERMIAILSENY------------GGKWPFWLS----------------------------------PRQVMVIPVGPTCEKYALQVSSEFFEEGFMADVDLD-HSCTLNKKIRNAQLAQ............................................ 298

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Friedberg I. and Godzik A Connecting the Protein Structure Universe by Using Sparse Recurring Fragments. Structure (Camb.) (2005) Aug;13(8):1213-24