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Query: 5w25_A mol:protein length:616 Aspartate--tRNA(Asp/Asn) ligase, from PDB1018

Results of FFAS03 search in H.sapiens
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MGSSSSGLVPRGSHVFVLRSHAAGLLREGDAGQQVTLAGWVARRRDHGGVIFIDLRDASGIAQVVFRDPQDTEVLAQAHRLRAEFCVSVAGVVEIRPEGNANPEIATGEIEVNATSLTVLGECAPLPFQLDEPAGEELRLKYRYLDLRRDDPAAAIRLRSRVNAAARAVLARHDFVEIETPTITRSTPEGARDFLVPARLHPGSFYALPQSPQLFKQLLMVAGMERYYQIARCYRDEDFRADRQPEFTQLDMEMSFVDAEDIIAISEEVLTELWALIGYRIPTPIPRIGYAEAMRRFGTDKPDLRFGLELVECTDFFSDTTFRVFQAPYVGAVVMPGGASQPRRTLDGWQDWAKQRGHRGLAYVLVAEDGTLGGPVAKNLTEAERTGLADHVGAKPGDCIFFSAGPVKSSRALLGAARVEIANRLGLIDPDAWAFVWVVDPPLFEPADEATAAGEVAVGSGAWTAVHHAFTAPKPEWEDRIESDTGSVLADAYDIVCNGHEIGGGSVRIHRRDIQERVFAVMGLDKAEAEEKFGFLLEAFMFGAPPHGGIAFGWDRTTALLAGMDSIREVIAFPKTGGGVDPLTDAPAPITAQQRKESGIDAQPKRVQQALast
1 -97.100sp|Q6PI48|SYDM_HUMAN Aspartyl-tRNA synthetase, mitochondrial OS=Homo sapiens GN=DARS2 PE=1 SV=1 (Range: 1-300)  ali follow..  47  35.QSSQRRIPEFSS--FVVRTNTCGELRSSHLGQEVTLCGWIQYRRQNT---FLVLRDFDGLVQVIIPQDEAASVKKILCEAPVESVVQVSGTVISRPAGQENPKMPTGEIEIKVKTAELLNACKKLPFEIKNKKTEALRLQYRYLDLRSFQMQYNLRLRSQMVMKMREYLNLHGFVDIETPTLFKRTPGGAKEFLVPSR-EPGKFYSLPQSPQQFKQLLMVGGLDRYFQVARCYRDEGSRPDRQPEFTQIDIEMSFVDQTGIQSLIEGL..................................................................................................................................................................................................................................................................................................................................................... 300
2 -90.000sp|P14868|SYDC_HUMAN Aspartyl-tRNA synthetase, cytoplasmic OS=Homo sapiens GN=DARS PE=1 SV=2  ali follow..  23  16.EIMDAAEDYAKERY-DRVLVRVRDLTIQKADEVVWVRARVHTSRAKGKQCFLVLRQQQFNVQALVAVGDSKQMVKFAANINKESIVDVEGVVRKVNQK--IGSCTQQDVELHVQKIYVISLAPRLPLQLDDTVNQDTRLDNRVIDLRTSTSQAVFRLQSGICHLFRETLINKGFVEIQTPKIISAASEGGANVFTVSYFKNNAY--LAQSPQLYKQMCICADFEKVFSIGPVFRAEDSNTHRHTEFVGLDIEMAFNYYHEVMEEIADTMVQIFKGLQERFQTEIQTVNKQFPCEPFKFLEPTLR--LEYCEALAMLREAGVEMGDEDDLSTPNEKLLGHLVKEKYDT-------------------------------------------------------------------------------------DFYILDKYPL---------------------AVRPFYTMPDPRN---------PKQSNSYDMFMRGEEILSGAQRIHDPQLLTERALHHGIDLEK----IKAYIDSFRFGAPPHAGGGIGLERVTMLFLGLHNVRQTSMFPRDPK................................ 497
3 -88.900sp|Q6PI48|SYDM_HUMAN Aspartyl-tRNA synthetase, mitochondrial OS=Homo sapiens GN=DARS2 PE=1 SV=1 (Range: 151-450)  ali follow..  38  2........................................................................................................................CKKLPFEIKNFVKKTEALRLQYRYLDLRSFQMQYNLRLRSQMVMKMREYLCNHGFVDIETPTLFKRTPGGAKEFLVPSR-EPGKFYSLPQSPQQFKQLLMVGGLDRYFQVARCYRDEGSRPDRQPEFTQIDIEMSFVDQTGIQSLIEGLLQYSWPNDKDPVVVPFPTMTFAEVLATYGTDKPDTRFGMKIIDISDVFRNTEIGFLQDALSKPCIPEGAKYLKRKDIESIRNFAADHFNQEILPVFLNANRNWNSPVANFIMESQRLELIRLMETQEEDVVLLTAGEHNKACS...................................................................................................................................................................................................... 300
4 -79.700sp|Q15046|SYK_HUMAN Lysyl-tRNA synthetase OS=Homo sapiens GN=KARS PE=1 SV=3  ali follow..  17  86.QLKVNGEDPYPHKF--HVDISLTDFIQKYTDITLKVAGRIHAKRASGKLIFYDLRGEGVKLQVMANSRNEEEFIHINNKLRRGDIIGVQGNPG---------KTKKGELSIIPYEITLLSPCHMLPHLHFGLKDKETRYRQRYLDLLNDFVRQKFIIRSKIITYIRSFLDELGFLEIETPMMNIIPGGAVAKPFITYHNELDMNLYMRIAPELYHKMLVVGGIDRVYEIGRQFRNEGIDLTHNPEFTTCEFYMAYADYHDLMEITEKMVSGMVKHITGSY-----KVTYHPDGPEGQAYDVDFTPPFRRINMVEELEKALGMKLPET---------------------------------------NLFETEETRKILDDICVAKAVECPPPRTTARLL---------------------------------------------------DKLVGEFLEVTCINPTFICDHPQIMSPLAKWHRSKEGLTERFELFVMKKEICNAYTELNDPMRQRQLFEEQAKGDDEAMFIDENFCTALEYGLPPTAGWGMGIDRVAMFLTDSNNIKEVLLFPAMKPEDKKENVATTDTLESTTVGTSV.......... 597
5 -78.700sp|O43776|SYNC_HUMAN Asparaginyl-tRNA synthetase, cytoplasmic OS=Homo sapiens GN=NARS PE=1 SV=1  ali follow..  21  97.EAKKITIKNDPSL--PEPKCVKIGALEGYRGQRVKVFGWVHRLRRQGKLMFLVLRDGTGYLQCVLADELCQC--YNGVLLSTESSVAVYGMLNLTPKG----KQAPGGHELSCDFWELIGLAPAGGADINEESDVDVQLNNRHMMIRGENMSKILKARSMVTRCFRDHFFDRGYYEVTPPTLVQTQVEGGATLFKLDYFGEEAF--LTQSSQLYLE-TCLPALGDVFCIAQSYRAEQSRTRRHAEYTHVEAECPFLTFDDLLNRLEDLVCDVVDRILKSPKRPFKRMNYSDAIVWLKEHDVKKEDGTFYEFGEDIPEAPE--------------------------------------------------------------------------------------------------------RLMTDTINEPILLCRFP----------------------VEIKSF---------MQRCPEDSRLTESVDVLMPNVEIVGGSMRIFDSEEILAGYKREGIDPTP----YYWYTDQRKYGTCPHGGYGLGLERFLTWILNRYHIRDVCLYPRFVQ................................ 544
6 -76.900sp|Q96I59|SYNM_HUMAN(removed signalp:1-16) Probable asparaginyl-tRNA synthetase, mitochondrial OS=Homo sapiens GN=NARS2 PE=1 SV=3  ali follow..  20  1........APFPKHKPSAKLSVRDALGANASGERIKIQGWIRSVRSQKEVLFLHVNDGSSLESLQVVADSGLD----SRELNFGSSVEVQGQLIKSPSKRQN-------VELKAEKIKVIGNCKDFPIKYKERHPLEYLRQYPHFRCRTNVLGSILRIRSEATAAIHSFFKDSGFVHIHTPIITSNDSEGAGELFQLEPSGKNVPAFLTVSGQLHLEVM-SGAFTQVFTFGPTFRAENSQSRRHAEFYMIEAEISFVDSQDLMQVIEELFKATTMMVLSKCPEDVELCHKFIAPGQKDRLEHMLKNNFLIISYTEAVEILKQASQNFTFTPEWGADLRTEHEKYLVKHCGN----------------------------------------------------------------------------------IPVFVINYP----------------------LTLKPFYMRD-------NEDGPQHTVAAVDLLVPGVELFGGGLREERYHFLEERLARSGLTEV-----YQWYLDLRRFGSVPHGGFGMGFERYLQCILGVDNIKDVIPFPRFPHSCLL............................ 461
7 -76.600sp|Q6PI48|SYDM_HUMAN Aspartyl-tRNA synthetase, mitochondrial OS=Homo sapiens GN=DARS2 PE=1 SV=1 (Range: 301-600)  ali follow..  31  1.............................................................................................................................................................................................................................................................................LQYSWPNDKDPVVVPFPTMTFAEVLATYGTDKPDTRFGMKIIDISDVFRNTEIGFLQDALSKPCIPEGAKYLKRKDIESIRNFAADHFNQEILPVFLNANRNWNSPVANFIMESQRLELIRLMETQEEDVVLLTAGEHNKACSLLGKLRLECADLVVLRDPTLFSFLWVVDFPLFLPKEE---------NPRELESAHHPFTAPHPSDIHLLYTEPKKARSQHYDLVLNGNEIGGGSIRIHNAELQRYILATLL---KEDVKMLSHLLQALDYGAPPHGGIALGLDRLICLVTGSPSIRD......................................... 300
8 -70.500sp|Q6PI48|SYDM_HUMAN Aspartyl-tRNA synthetase, mitochondrial OS=Homo sapiens GN=DARS2 PE=1 SV=1 (Range: 451-645)  ali follow..  39  1............................................................................................................................................................................................................................................................................................................................................................................................................................LLGKLRLECADLLELRDPTLFSFLWVVDFPLFLPKEE---------NPRELESAHHPFTAPHPSDIHLLYTEPKKARSQHYDLVLNGNEIGGGSIRIHNAELQRYILATLLKEDVK---MLSHLLQALDYGAPPHGGIALGLDRLICLVTGSPSIRDVIAFPKSFRGHDLMSNTPDSVPPEELKPYHIRVSKPTDSKA 191
9 -11.700sp|P12081|SYHC_HUMAN Histidyl-tRNA synthetase, cytoplasmic OS=Homo sapiens GN=HARS PE=1 SV=2  ali follow..  11  6.......................................................................................ALEELVKLQGERVRGLKQQKASAELIEEEVAKLLKLKAQLGPDESKQKFVLKTPKGTRDY----SPRQMAVREKVFDVIIRCFKRHGAEVIDTPVFLMGKYGEDSKLIYDLKDQGGELLSLYDLTVPFARYLAMNKLTKRYHIAKVYRRDAMTRGRYREFYQCDFDIPMIPDAECLKIMCEILSSL------------------------QIGDFLVKVN-------------DRRILDGMFAICGVSDSKFRTICSSVDKLDKVSWEEVKNEMVGEKGLAPEVADRIGDYVQQHGGVSLVEQLLQDPKLSQNKQALEGLGDLKLLFEYLTLFGIDDKISFDLSLARGLDYYTGVIYEAVLLQTPAQAGEEPLG-------------------------------------GSVAAGG--------------------------RYDGLVGMFDPKGRPCVGLSIGVERIFSIVEQRTTETQVLVASAQKKLLEERLKLVSELWDAGIK.............. 437
10 -11.300sp|Q9P2K8|E2AK4_HUMAN Eukaryotic translation initiation factor 2-alpha kinase 4 OS=Homo sapiens GN=EIF2AK4 PE=1 SV=3 (Range: 1051-1350)  ali follow..  18  3...................................................................................................................................................KGNFSIRTAKMQQHVCETIIRIFKRHGAVQLCTPLLLRNRQIYEHNEAALFMDHSGMLVMLPFDLRIFARYVARNNILKRYCIERVFRPRKLDRFHPKELLECAFDISFLPTAEIIYTIYEIIQEF................................................................................................................................................................................................................................................................................................................................................. 138
11 -10.700sp|P07814|SYEP_HUMAN Bifunctional aminoacyl-tRNA synthetase OS=Homo sapiens GN=EPRS PE=1 SV=5 (Range: 901-1200)  ali follow..  11  9............................ASQGEVVRKLKTEKAPKDQVDIAVQELLQLKAQYKSLIGVEYKPVSATGAEDKDKKKKEKENKSEKQNKPQKQNDGQRKDPSKSSSGAGEGQGPKKQTRLGLEAKKEENLADWYSQVITKSEMIEYHYAIWEAIKDFFDAEIKKLGVENCYFPMFVSQKTELAEPIAIRPTSETVMYPAYAKWVQSHRDLPI-----KLNQWCNVVRWEFKHPQRTREFLWQEGHSAFATMEEAAEEVLQILD................................................................................................................................................................................................................................................................................................................................................... 291
12 -10.600sp|P49590|SYHM_HUMAN(removed signalp:1-13) Probable histidyl-tRNA synthetase, mitochondrial OS=Homo sapiens GN=HARS2 PE=1 SV=1  ali follow..  11  34...................................................................................................................................KAHQEKPNFIIKTPKGTRDLSPQHMVVREKILDLVISCFKRHGAKGMDTPAFLTEKYGEDSGLMYDLKDQGGELLSLYDLTVPFARYLAMNKVKKRYHVGKVWRRETIVQGRYREFCQCDFDIPMIPDAECLKIMCEILSGL------------------------QLGDFLIKVN-------------DRRIVDGMFAVCGVPESKFRAICSSIDKLDKMAWKDVRHEMVVKKGLAPEVADRIGDYVQCHGGVSLVEQMFQDPRLSQNKQALEGLGDLKLLFEYLTLFGIADKISFDLSLARGLDYYTGVIYEAVLLQTPTQAGEEPLN-------------------------------------GSVAAGG--------------------------RYDGLVGMFD----PCVGLSIGVERIFYIVEQRMKTKQVFVATPQKNFLQERLKLIAELWDSGIK.............. 425
13 -9.880sp|P15927|RFA2_HUMAN Replication protein A 32 kDa subunit OS=Homo sapiens GN=RPA2 PE=1 SV=1  ali follow..  13  42...RAQHIVPCTISQLLSATLVDEVFRIGNVESQVTIVGIIRHAEKAPTNIVYKIDDMTAAPMDVRQWVDTDDTSSENTVVPPETYVKVAGHLRS-----------QNKKSLVAFKIMPLEDMNEFTTHILEVINAHMVLSKANSQPSAGRAPISNPGMSEAGNFGGNSFMPANGLTVAQNQVLNLIKACPRPEGLNFQDLKNQLKHMSVSSKQAVDFLSNEG--HIYSTV----DDD-------HFKSTDAE..................................................................................................................................................................................................................................................................................................................................................................... 270

FFAS is supported by the NIH grant R01-GM087218-01
1 2 7 8 0 1   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Zhao Y, Hong DH, Pawlyk B, Yue G, Adamian M, Grynberg M, Godzik A., Li T. The retinitis pigmentosa GTPase regulator (RPGR)- interacting protein: subserving RPGR function and participating in disk morphogenesis. Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):3965-70. Epub 2003 Mar 21.