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Query: 1wva_A mol:protein length:322 Arginase 1, from PDB1018

Results of FFAS03 search in PDB1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MSAKSRTIGIIGAPFSKGQPRGGVEEGPTVLRKAGLLEKLKEQECDVKDYGDLPFADIPNDSPFQIVKNPRSVGKASEQLAGKVAEVKKNGRISLVLGGDHSLAIGSISGHARVHPDLGVIWVDAHTDINTPLTTTSGNLHGQPVSFLLKELKGKIPDVPGFSWVTPCISAKDIVYIGLRDVDPGEHYILKTLGIKYFSMTEVDRLGIGKVMEETLSYLLGRKKRPIHLSFDVDGLDPSFTPATGTPVVGGLTYREGLYITEEIYKTGLLSGLDIMEVNPSLGKTPEEVTRTVNTAVAITLACFGLAREGNHKPIDYLNPPKLast
1 -98.8001wva_A mol:protein length:322 Arginase 1  ali model  100  1MSAKSRTIGIIGAPFSKGQPRGGVEEGPTVLRKAGLLEKLKEQECDVKDYGDLPFADIPNDSPFQIVKNPRSVGKASEQLAGKVAEVKKNGRISLVLGGDHSLAIGSISGHARVHPDLGVIWVDAHTDINTPLTTTSGNLHGQPVSFLLKELKGKIPDVPGFSWVTPCISAKDIVYIGLRDVDPGEHYILKTLGIKYFSMTEVDRLGIGKVMEETLSYLLGRKKRPIHLSFDVDGLDPSFTPATGTPVVGGLTYREGLYITEEIYKTGLLSGLDIMEVNPSLGKTPEEVTRTVNTAVAITLACFGLAREGNHKPIDYLNPPK 322
2 -96.6001d3v_A mol:protein length:323 PROTEIN (ARGINASE)  ali model follow..  85  1MSSKPKPIEIIGAPFSKGQPRGGVEKGPAALRKAGLVEKLKETEYNVRDHGDLAFVDVPNDSPFQIVKNPRSVGKANEQLAAVVAETQKNGTISVVLGGDHSMAIGSISGHARVHPDLCVIWVDAHTDINTPLTTSSGNLHGQPVAFLLKELKGKFPDVPGFSWVTPCISAKDIVYIGLRDVDPGEHYIIKTLGIKYFSMTEVDKLGIGKVMEETFSYLLGRKKRPIHLSFDVDGLDPVFTPATGTPVVGGLSYREGLYITEEIYKTGLLSGLDIMEVNPTLGKTPEEVTRTVNTAVALTLSCFGTKREGNHKPETDYLKPP 322
3 -94.3001pq3_A mol:protein length:306 Arginase II, mitochondrial precursor  ali model follow..  60  1.....HSVAVIGAPFSQGQKRKGVEHGPAAIREAGLMKRLSSLGCHLKDFGDLSFTPVKDDLYNNLIVNPRSVGLANQELAEVVSRAVSDGYSCVTLGGDHSLAIGTISGHARHCPDLCVVWVDAHADINTPLTTSSGNLHGQPVSFLLRELQDKVPQLPGFSWIKPCISSASIVYIGLRDVDPPEHFILKNYDIQYFSMRDIDRLGIQKVMERTFDLLIGKRQRPIHLSFDIDAFDPTLAPATGTPVVGGLTYREGMYIAEEIHNTGLLSALDLVEVNPQLATSEEEAKTTANLAVDVIASSFGQTREG............ 306
4 -94.3001t5f_A mol:protein length:314 Arginase 1  ali model follow..  86  1.....KPIEIIGAPFSKGCPRGGVEKGPAALRKAGLVEKLKETEYNVRDHGDLAFVDVPNDSPFQIVKNPRSVGKANEQLAAVVAETQKNGTISVVLGGDHSMAIGSISGHARVHPDLAVIWVDAHTDINTPLTTSSGNLAGQPVAFLLKELKGKFPDVPGFSWVTPAISAKDIVYIGLRDVDPGEHYIIKTLGIKYFSMTEVDKLGIGKVMEETFSYLLGRKKRPIHLSFDVDGLDPVFTPATGTPVVGGLSYREGLYITEEIYKTGLLSGLDIMEVNPTLGKTPEEVTRTVNTAVALTLSAFGTKREGNHKP........ 309
5 -86.7005ynl_A mol:protein length:362 Arginase  ali model follow..  47  45FLATPRTAGIVGCPFSGGQPKAGVHSGPLQLIESGLLNDIENLGWTVDFAGADALAVSIVSDTPDPLKQPRLVSRVTKDVADRVYAHASKGQLTVTLGGDHSLAMGTVSGTFKAYPEACLIWVDAHADINTPHTTESGRLHGCPVSFLLGLDGTSSEEIPEFSWIKPCLKPERIVYIGLRDIDAGERKILKDNNIKCFSMFHVDKYGIGKVVEMALDHVNPDRTRPIHLSFDVDALDPSVAPSTGTAVRGGLTFREGHYICEAIAETNLLVSLDIMEINPSLGALASVA-QTVDVGRSLVRCALGETL.............. 355
6 -86.1002eiv_A mol:protein length:291 Arginase  ali model follow..  37  2.....ERVAVVGVPMDLGANRRGVDMGPSALRYARLLEQLEDLGYTVEDLGDVPVSLARASRRRGRGLAYLEEIRAAALVLKERLAALPEGVFPIVLGGDHSLSMGSVAGAAR-GRRVGVVWVDAHADFNTPETSPSGNVHGMPLAVLSGLGHPRLTEV------FRAVDPKDVVLVGVRSLDPGEKRLLKEAGVRVYTMHEVDRLGVARIAEEVLKHL---QGLPLHVSLDADVLDPTLAPGVGTPVPGGLTYREAHLLMEILAESGRVQSLDLVEVNPILDERNRTAEMLVGLALSLLGKRI.................. 290
7 -83.4006dkt_A mol:protein length:296 Arginase  ali model follow..  40  2....DKTISVIGMPMDLGQARRGVDMGPSAIRYAHLIERLSDMGYTVEDLGDIPINREK-IKNDEELKNLNSVLAGNEKLAQKVNKVIEEKKFPLVLGGDHSIAIGTLAGTAKHYDNLGVIWYDAHGDLNTLETSPSGNIHGMPLAVSLGIGH---ESLVNLEGYAPKIKPENVVIIGARSLDEGERKYIKESGMKVYTMHEIDRLGMTKVIEETLDYL--SACDGVHLSLDLDGLDPNDAPGVGTPVVGGISYRESHLAMEMLYDAGIITSAEFVEVNPILDHKNKTGKTAVELVESLLGKKL.................. 295
8 -82.3004ity_A mol:protein length:330 Arginase  ali model follow..  41  4.SGMAKKMSIVLAPFSGGQPHSGVELGPDYLLKQGLQQDMEKLGWDTRLERVFDGKVVEARKASDRVKRPRLTAECTEKIYKCVRRVAEQGRFPLTIGGDHSIALGTVAGVLSVHPDAGVIWVDAHADINTMSGTVSGNLHGCPLSILLGLDRENIPEC--FSWVPQVLKPNKIAYIGLRAVDDEEKKILHDLNIAAFSMHHVDRYGIDKVVSMAIEAVSPKGTEPVMVSYDVDTIDPLYVPATGTPVRGGLSFREALFLCERIAECGRLVALDVVECNPLLAATESHVNDTISVGCAIARCMMGETLLYTPHTSSKL.... 324
9 -82.2001cev_A mol:protein length:299 PROTEIN (ARGINASE)  ali model follow..  40  2.....KPISIIGVPMDLGQTRRGVDMGPSAMRYAGVIERLERLHYDIEDLGDIPIGKAERLHEQGRLRNLKAVAEANEKLAAAVDQVVQRGRFPLVLGGDHSIAIGTLAGVAKHYERLGVIWYDAHGDVNTAETSPSGNIHGMPLAASLGFGH---PALTQIGGYSPKIKPEHVVLIGVRSLDEGEKKFIREKGIKIYTMHEVDRLGMTRVMEETIAYL-KERTDGVHLSLDLDGLDPSDAPGVGTPVIGGLTYRESHLAMEMLAEAQIITSAEFVEVNPILDERNKTASVAVALMGSLFGEKL.................. 298
10 -79.9004q3p_A mol:protein length:385 Arginase  ali model follow..  40  33.KLLYTSANFLGIPTNRGQPKIGTYQGPELIRKSNFFQLVAEDGIQLTDCGDIIPVELNEAESLTTLRIAERVEELMKQSNKHTVELSGSKSTPVIVGGDHSMATGTILGHAEAKPDLCVLWIDAHGDINTPLNSASGNMHGMPLSFLVKELQDQIPWLDDFEGIKPCLNASNIAYIGLRDLDAHETHDIRKHGIAYFTMLDVDRMGIEAVIKEALLAVNPRLEKAIHLSFDIDALDPLVAPSTGTAVPGGLTLREGLRICEEVSATGKLSVVELAELNPLLGSQEDVL-KTQSSAVHILRACLGHCRSGHLPF........ 358
11 -74.5004g3h_A mol:protein length:330 Arginase (RocF)  ali model follow..  19  1.......MILVGLEAELGASKRGTDKGVRRLREALSATHGDVIKGMQT-----QERCVLYKEFRYAKNFEDYYLFCKENLIPCMKEVFEKKEFPLILSSEHANMFGIFQAFRSVHKKIGILYLDAHADIHTAYDSDSKHIHGMPLGMVLNRVRSGFNRMSGLEKGGLEIDPKCLVYFGVRSTEQSERDVIRELQIPLFSVDAIRE-NMQEVVQKTKESL--KAVDIIYLSLDLDIMDGKLFTSTGVRENNGLSFDELKQLLGLLLESDRLKAVEVTEYNPTVSIKHNNEKQVLEILDLIINSCKIKDKKHSFARS....... 321
12 -72.4003nio_A mol:protein length:319 Guanidinobutyrase  ali model follow..  24  34.ELDALDAAFVGVPLDIGSLRSGTRFGPREIRAESVMIRPYNMATGAAPFDSLNVADIG-----DVAINTFNLLEAVRIIEQEYDRILGHGILPLTLGGDHTITLPILRAIKKKHGKVGLVHVDAHADVNDHMFG-EKIAHGTTFRRAVEED---------------LLDCDRVVQIGLRAQTAEDFNWSRKQGFRVVQAEECWHKSLEPLMAEVREKV---GGGPVYLSFDIDGIDPAWAPGTGTPEIGGLTTIQAMEIIRGCQGL-DLIGCDLVEVSPPYDTTGNTSLLGANLLYEMLCVLPGVVRR............. 319
13 -71.9003lhl_A mol:protein length:287 Putative agmatinase  ali model follow..  21  4.NYEESNLIVFGVGFDGTSNRPGARFASSSMRKEFYGLETYSPFL------DLDLEDYNICDYGDLEISVGSTEQVLKEIYQETYKIVRDSKVPFMIGGEHLVTLPAFKAVHEKYNDIYVIHFDAHTDLREEYNN-SKNSHATVIKRIWD-----------------IVGDNKIFQFGIRSGTKEEFKFATEEKHTYMEIGGID------TFENIVNML---NGKNIYLTIDLDVLDASVFPGTGTPEPGGVNYREFQEIFKIIKNSNNIVGCDIVELSPDYDTTGVSTVIACKILRELCLIISDKIKEG............ 281
14 -71.9001gq6_A mol:protein length:313 PROCLAVAMINATE AMIDINO HYDROLASE  ali model follow..  25  26.QPRGYDVVVIGAPYDGGSYRPGARFGPQAIRSESGLIHGVGIDRGPGTFDLINCVDAG-----DINLTPFDMNIAIDTAQSHLSGLLKANAAFLMIGGDHSLTVAALRAVAEQHGPLAVVHLDAHSDTNPAFYG-GRYHHGTPFRHGIDEK---------------LIDPAAMVQIGIRGHKPDSLDYARGHGVRVVTADEFGELGVGGTADLIREKV---GQRPVYVSVDIDVVDPAFAPGTGTPAPGGLLSREVLALLRCVGDL-KPVGFDVMEVSPLYDHGGITSILATEIGAELLYQYARAHRT............. 311
15 -71.8003nip_A mol:protein length:326 3-guanidinopropionase  ali model follow..  24  31.DPAALQVGLIGVPWDGGTNRAGARHGPREVRNLSSLMRKVHHVSRIAPYDLVRVGDLG-----DAPVNPIDLLDSLRRIEGFYRQVHAAGTLPLSVGGDHLVTLPIFRALGR-ERPLGMVHFDAHSDTNDRYFGDNPYTHGTPFRRAIEEG---------------LLDPLRTVQIGIRGSSPDDDAFARECGIRVIHMEEFVELGVEATLAEARRVV---GAGPTYVSFDVDVLDPAFAPGTGTPEIGGMTSLQAQQLVRGLRGL-DLVGADVVEVSPPFDVGGATALVGATMMFELLCLLAESAARSALE......... 320
16 -70.6003mmr_A mol:protein length:413 Arginase  ali model follow..  31  14.HMASKNVSIIGSPLAAGQPLGGVQLACDDLRKLGLHNVIDVLGWKYEDIGNIDNGDNENNCYYDNIRNIKEIGIFSKNLFDTMSNELRKKNFVLNIGGDHGVAFSSILSSLQMYQNLRVIWIDAHGDINIPETSPSGNYHGMTLAHTLGLFKKKVPYF-EWSENLTYLKPENTAIIGIRDIDAYEKIILKKCNINYYTIFDIEKNGIYNTICTALEKIDPNSNCPIHISLDIDSVDNVFAPGTGTVAKGGLNYREINLLMKILAETKRVVSMDLVEYNPSLDEVDKKVHGDSLPILDLIARVLGYD............... 405
17 -70.5003m1r_A mol:protein length:322 Formimidoylglutamase  ali model follow..  21  34.GQDIKGPALIGVPLSKSISHSGASFAPGTIRQALKHSSAYSAELGE------HVVSELLYDLGDIDIHVTDIVKSHHHIFQTMHALLSDHPVPLILGGDNSISYSTIKAIAQTKGTTAVIQFDAHHDVRNTEDG--GPTNGTPFRRLLDEE---------------IIEGQHLIQLGIREFSQAYEAYAKKHNVNIHTMDMIREKGLIPTIKEILPVV-QDKTDFIFISVDMDVLDQSHAPGCPAIGPGGLYTDELLEAVKYIAQQPNVAGIEIVEVDPTLDFRDMTSRAAAHVLLHALKGMKLSPFK............. 322
18 -69.3004dz4_A mol:protein length:324 Agmatinase  ali model follow..  24  43.DLDGVDVVVSGVPLDLATFRSGARLGPSAVRAASVQLAELNPYPW----GFDPFDDLAVIDYGDCWFDAHHPLSIKPAIVEHARTILQSDARMLTLGGDHYITYPLLIAHAQKYGPLSLIHFDAHCDTWADDAP-DSLNHGTMFYKAVKDG---------------LIDPKASVQVGIRTWNDDY------LGINVLDAAWVHEHGARATLERIESIV---GGRPAYLTFDIDCLDPAFAPGTGTPVAGGLSSAQALAIVRGLGGV-NLIGADVVEVAPAYDQSEITAIAAAHVACDLLCLWRQRKAGAR........... 324
19 -69.3001wog_A mol:protein length:305 agmatinase  ali model follow..  23  24DGDWQADVAALGVPFDIAGFRPGARFAPRALREASLRSVPPFTGLD----GKTRLQGVTFADAGDVILPSLEPQLAHDRITEAARQVRGRCRVPVFLGGDHSVSYPLLRAFAD-VPDLHVVQLDAHLDFTDTRND-TKWSNSSPFRRACEAL----------------PNLVHITTVGLRGLDPEAVAAARARGHTIIPMDDVTADLAGVLAQLP-------RGQNVYFSVDVDGFDPAVIPGTSSPEPDGLTYAQGMKILAAAAANNTVVGLDLVELAPNLDPTGRSELLMARLVMETLCEVFDHV............... 304
20 -67.3003pzl_A mol:protein length:313 Agmatine ureohydrolase  ali model follow..  24  31.GYEEAKYVVFGIPFDNTSYRRGSKYAPDSIRGAYVNLESYEYSYGI-DLLASGMADLGDMEE------SEDVEYVIDTVESVVSAVMSDGKIPIMLGGEHSITVGAVRALPK---DVDLVIVDAHSDFRSSYMG-NKYNHACVTRRALD-----------------LLGEGRITSIGIRSVSREEFEDPDFRKVSFISSFDVKKNGIDKYIEEVDR-----KSRRVYISVDMDGIDPAYAPAVGTPEPFGLADTDVRRLIERLSY--KAVGFDIVEFSPLYD-NGNTSMLAAKLLQVFIASREKYYKE............. 303
21 -66.3002a0m_A mol:protein length:316 ARGINASE SUPERFAMILY PROTEIN  ali model follow..  23  20.REEDADIVIIGFPYDEGGGRAGAKKGPAAFRFFLQRLGSVNNLELNVDASHLKLYDAGDIT-------ASTLEEAHEKLESKVFTVLARGAFPFVIGGGNDQSAPNGRAMLRAFGDVGVINVDSHLDVRPPLQD-GRVHSGTPFRQLLEES---------------SFSGKRFVEFACQGSGALHAQYVRDHQGHLMWLSEVRKKGAVAALEDAFGLTG----KNTFFSFDVDSLKSSDMPGVSCPAAVGLSAQEAFDMCFLAGKTPTVMMMDMSELNPLVE-EYRSPRVAVYMFYHFVLGFATRPKPKAEN......... 310
22 -65.0004rhm_A mol:protein length:351 Arginase  ali model follow..  17  15....MFSKFLMNVKGVTPGSDWANRLGPVALFGYGAGMPRRAAELTIHDKGPIECPNCGQMLDEAAGTETPTSDEWYLGSLEASTELLEKGYVPVSVGGDGSATLSMVEAYKRLFPDIVIVHFDAHPDVSD---------PRSPLRVLLDKGL-----------------LKGVVSVGNRQVSSEDRKVRKLHKMFYMDMHAIYSKGLFCIRDIR-------NDYPVFISIDADVLDPAFAPAVDSPVAGGLSTRDLLHIMNGIRGP-KVVGIDVYGYNPDLDNVGLTAIALSKIIKEGILKAYSISTHTEEEGMERVKMLQ 332
23 -62.8004rhi_A mol:protein length:351 Arginase  ali model follow..  17  18...KFLMNVKGVTPRG---SDWANRLGPVALFGYGAGMPRRAAELTIHDKGPIECPNCGQMLDEAAGTETPTSDEWYLGSLEASTELLEKGYVPVSVGGDGSATLSMVEAYKRLFPDIVIVHFSARPSVSD---------PRSPLRVLLDKGL-----------------LKGVVSVGNRQVSSEDRKVRKLHKMFYMDMHAIYSKGLFCIRDIR-------NDYPVFISIDASVLDPAFAPAVDSPVAGGLSTRDLLHIMNGIRGP-KVVGIDVYGYNPDLDNVGLTAIALSKIIKEGILKAYSISTHTEEEGMERVKMLQ 332
24 -57.7001xfk_A mol:protein length:336 Formimidoylglutamase  ali model follow..  17  38LANQEPGVALIGFECDAGKGRTGAKHAPSLIKQALANLAWHH-PIPIYDLGNIRCEG-------------DELEQAQQECAQVIQQALPHA-RAIVLGGGHEIAWATFQGLAQHFPRIGIINFDAHFDLRTFESELAPVSSGTPFNQIHHFCQQQ--------------WDFHYACLGVSRATPALFERADKLGVWYVEDKAFSPLSLKDHLTQLQHFI--DDCDYLYLTIDLDVFPAASAPGVSAPAARGVSLEALAPYFDRILHKNKLMIADIAEYNPSFDIDQHTARLAARLCWDIANAMAEQVQSIRHP......... 336

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Pawlowski K, Pio F, Chu Z, Reed JC, Godzik A. PAAD - a new protein domain associated with apoptosis, cancer and autoimmune diseases. Trends Biochem Sci. 2001 Feb;26(2):85-7.