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Query: 2g4c_A mol:protein length:474 DNA polymerase gamma subunit 2, from PDB1018

Results of FFAS03 search in PDB1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MRGSGSTMDAGQPELLTERSSPKGGHVKSHAELEGNGEHPEAPGSGEGSEALLEICQRRHFLSGSKQQLSRDSLLSGCHPGFGPLGVELRKNLAAEWWTSVVVFREQVFPVDALHHKPGPLLPGDSAFRLVSAETLREILQDKELSKEQLVTFLENVLKTSGKLRENLLHGALEHYVNCLDLVNKRLPYGLAQIGVCFHPVFDTKQIRNGVKSIGEKTEASLVWFTPPRTSNQWLDFWLRHRLQWWRKFAMSPSNFSSSDCQDEEGRKGNKLYYNFPWGKELIETLWNLGDHELLHMYPGNVSKLHGRDGRKNVVPCVLSVNGDLDRGMLAYLYDSFQLTENSFTRKKNLHRKVLKLHPCLAPIKVALDVGRGPTLELRQVCQGLFNELLENGISVWPGYLETMQSSLEQLYSKYDEMSILFTVLVTETTLENGLIHLRSRDTTMKEMMHISKLKDFLIKYISSAKNVLast
1 -160.0002g4c_A mol:protein length:474 DNA polymerase gamma subunit 2  ali model  100  1MRGSGSTMDAGQPELLTERSSPKGGHVKSHAELEGNGEHPEAPGSGEGSEALLEICQRRHFLSGSKQQLSRDSLLSGCHPGFGPLGVELRKNLAAEWWTSVVVFREQVFPVDALHHKPGPLLPGDSAFRLVSAETLREILQDKELSKEQLVTFLENVLKTSGKLRENLLHGALEHYVNCLDLVNKRLPYGLAQIGVCFHPVFDTKQIRNGVKSIGEKTEASLVWFTPPRTSNQWLDFWLRHRLQWWRKFAMSPSNFSSSDCQDEEGRKGNKLYYNFPWGKELIETLWNLGDHELLHMYPGNVSKLHGRDGRKNVVPCVLSVNGDLDRGMLAYLYDSFQLTENSFTRKKNLHRKVLKLHPCLAPIKVALDVGRGPTLELRQVCQGLFNELLENGISVWPGYLETMQSSLEQLYSKYDEMSILFTVLVTETTLENGLIHLRSRDTTMKEMMHISKLKDFLIKYISSAKNV 468
2 -154.0005c51_B mol:protein length:485 DNA polymerase subunit gamma-2, mitochondrial  ali model follow..  98  18LSGFGGRVDAGQPELLTERSSPKGGHVKSHAELEGNGEHPEAPGSGEGSEALLEICQRRHFLSGSKQQLSRDSLLSGCHPGFGPLGVELRKNLAAEWWTSVVVFREQVFPVDALHHKPGPLLPGDSAFRLVSAETLREILQDKELSKEQLVAFLENVLKTSGKLRENLLHGALEHYVNCLDLVNKRLPYGLAQIGVCFHPVFDTKQIRNGVKSIGEKTEASLVWFTPPRTSNQWLDFWLRHRLQWWRKFAMSPSNFSSSDCQDEEGRKGNKLYYNFPWGKELIETLWNLGDHELLHMYPGNVSKLHGRDGRKNVVPCVLSVNGDLDRGMLAYLYDSFQLTENSFTRKKNLHRKVLKLHPCLAPIKVALDVGRGPTLELRQVCQGLFNELLENGISVWPGYLETMQSSLEQLYSKYDEMSILFTVLVTETTLENGLIHLRSRDTTMKEMMHISKLKDFLIKYISSAKNV 485
3 -150.0004ztu_B mol:protein length:472 DNA polymerase subunit gamma-2, mitochondrial  ali model follow..  99  1.......MDAGQPELLTERSSPKGGHVKSHAELEGNGEHPEAPGSGEGSEALLEICQRRHFLSGSKQQLSRDSLLSGCHPGFGPLGVELRKNLAAEWWTSVVVFREQVFPVDALHHKPGPLLPGDSAFRLVSAETLREILQDKELSKEQLVAFLENVLKTSGKLRENLLHGALEHYVNCLDLVNKRLPYGLAQIGVCFHPVFDTKQIRNGVKSIGEKTEASLVWFTPPRTSNQWLDFWLRHRLQWWRKFAMSPSNFSSSDCQDEEGRKGNKLYYNFPWGKELIETLWNLGDHELLHMYPGNVSKLHGRDGRKNVVPCVLSVNGDLDRGMLAYLYDSFQLTENSFTRKKNLHRKVLKLHPCLAPIKVALDVGRGPTLELRQVCQGLFNELLENGISVWPGYLETMQSSLEQLYSKYDEMSILFTVLVTETTLENGLIHLRSRDTTMKEMMHISKLKDFLIKYISSAKNV 461
4 -134.0001g5h_A mol:protein length:454 MITOCHONDRIAL DNA POLYMERASE ACCESSORY SUBUNIT  ali model follow..  77  2..........................LSGYAGPADGTQQPDAPEHAVAREALVDLCRRRHFLSGTPQQLSTAALLSGCHARFGPLGVELRKNLASQWWSSMVVFREQVFAVDSLHQEPGSSQPRDSAFRLVSPESIREILQDREPSKEQLVAFLENLLKTSGKLRATLLHGALEHYVNCLDLVNRKLPFGLAQIGVCFHPVSNSNQTPSSVTRVGEKTEASLVWFTPTRTSSQWLDFWLRHRLLWWRKFAMSPSNFSSADCQDELGRKGSKLYYSFPWGKEPIETLWNLGDQELLHTYPGNVSTIQGRDGRKNVVPCVLSVSGDVDLGTLAYLYDSFQLAENSFARKKSLQRKVLKLHPCLAPIKVALDVGKGPTVELRQVCQGLLNELLENGISVWPGYSETVHSSLEQLHSKYDEMSVLFSVLVTETTLENGLIQLRSRDTTMKEMMHISKLRDFLVKYLASASNV 443
5 -131.0003ikl_A mol:protein length:459 DNA polymerase subunit gamma-2, mitochondrial  ali model follow..  98  22.GG---RVDAGQPELLTERSSPKGGHVKSHAELEGNGEHPEAPGSGEGSEALLEICQRRHFLSGSKQQLSRDSLLSGCHPGFGPLGVELRKNLAAEWWTSVVVFREQVFPVDALHHKPGPLLPGDS--------------------------------AFRGGLRENLLHGALEHYVNCLDLVNKRLPYGLAQIGVCFHPVFDTKQIRNGVKSIGEKTEASLVWFTPPRTSNQWLDFWLRHRLQWWRKFAMSPSNFSSSDCQDEEGRKGNKLYYNFPWGKELIETLWNLGDHELLHMYPGNVSKLHGRDGRKNVVPCVLSVNGDLDRGMLAYLYDSFQLTENSFTRKKNLHRKVLKLHPCLAPIKVALDVGRGPTLELRQVCQGLFNELLENGISVWPGYLETMQSSLEQLYSKYDEMSILFTVLVTETTLENGLIHLRSRDTTMKEMMHISKLKDFLIKYISSAKNV 453
6 -107.0001b76_A mol:protein length:442 Glycine--tRNA ligase  ali model follow..  23  1............................................AASSLDELVALCKRRGFIFQSSEIYGGLQ----GVYDYGPLGVELKNNLKQAWWRRNVYERDDMEGLDASVLTHRLVLHYSGHEATFADPMVDNAKARYWTPPRYFNMMFQGGRGLLAYLRPETAQGIFVNFKNVLDATSRKLGFGIAQIGKAFRNEITPRN---FIFRVREFEQMEIEYFVRPGEDEYWHRYWVEERLKWWQEMGLSRENLVPYQQPPESSAHYADILYRFPHGSLELEGIAQRTDFDLGSHTKDQEALGITPETGKWFVPYVIEPSAGVDRGVLALLAEAFTREEL----PNGEERIVLKLKPQLAPIKVAVIPLVKNRPEITEYAKRLKARLLALGLGR---VLYEDTGNIGKAYRRHDEVGTPFAVTVDYDTIGQSTVTVRDRDTMEQIRLHVDELEGFLRERLR..... 441
7 -105.0005c53_B mol:protein length:903 Pol gamma B  ali model follow..  98  19.SGFGGRVDAGQPELLTERSSPKGGHVKSHAELEGNGEHPEAPGSGEGSEALLEICQRRHFLSGSKQQLSRDSLLSGCHPGFGPLGVELRKNLAAEWWTSVVVFREQVFPVDALHHKPGPLLPGDSAFR---------------------------------KLRENLLHGALEHYVNCLDLVNKRLPYGLAQIGVCFHPVFDTKQIRNGVKSIGEKTEASLVWFTPPRTSNQWLDFWLRHRLQWWRKFAMSPSNFSSSDCQDEEGRKGNKLYYNFPWGKELIETLWNLGDHELLHMYPGNVSKLHGRDGRKNVVPCVLSVNGDLDRGMLAYLYDSFQLTENSFTRKKNLHRKVLKLHPCLAPIKVALDVGRGPTLELRQVCQGLFNELLENGISVWPGYLETMQSSLEQLYSKYDEMSILFTVLVTETTLENGLIHLRSRDTTMKEMMHISKLKDFLIKYISSAKNV 452
8 -96.6001ati_A mol:protein length:505 GLYCYL-TRNA SYNTHETASE  ali model follow..  24  1............................................AASSLDELVALCKRRGFIFQSSEIYGGLQ----GVYDYGPLGVELKNNLKQAWWRRNVYERDDMEGLDASVLTHRLVLHYSGHEATFADPMVDNRITKKRYRLDHLLKEQPEERGLLAYLRPETAQGIFVNFKNVLDATSRKLGFGIAQIGKAFRNEITPR---NFIFRVREFEQMEIEYFVRPGEDEYWHRYWVEERLKWWQEMGLSRENLVPYQQPPESSAHYADILYRFPHGSLELEGIAQRTDFDLGSHTKDQEALGITARTGKWFVPYVIEPSAGVDRGVLALLAEAFTREEL----PNGEERIVLKLKPQLAPIKVAVIPLVKNRPEITEYAKRLKARLLALGLGR---VLYEDTGNIGKAYRRHDEVGTPFAVTVDYDTIGQSTVTVRDRDTMEQIRLHVDELEGFLRERLR..... 504
9 -95.7002pme_A mol:protein length:693 Glycyl-tRNA synthetase  ali model follow..  17  20.QG-RKLKEDKAPQVDVDKAVAELKARK--RVLEAKELALQPKDDIVDRAKMEDTLKRRFFYDQAFAIYGGVS----GLYDFGPVGCALKNNIIQTWRQHFIQ-EEQILEIDCTMLTPEPVLKTSGHVDKFADFMVKDVKNGECFRADHLLTFIGPGGNMPGYLRPETAQGIFLNFKRLLEFNQGKLPFAAAQIGNSFRNEISPRS---GLIRVREFTMAEIEHFVDPSEKNTVLGYFIGRIYLYLTKVGISPDKLRFRQHMENEMAHYAMLLNEKGEFTIETEGKTFQLTKDMINVKRFQKTL-----YVEEVVPNVIEPSFGLGRIMYTVFEHTFHVRE------GDEQRTFFSFPAVVAPFKCSVLPLS-QNQEFMPFVKELSEALTRHGVSH---KVDDSSGSIGRRYARTDEIGVAFGVTIDFDTVNKTTATLRDRDSMRQIRAEISELPSIVQDLANGNIT. 661
10 -33.2004k86_A mol:protein length:535 Proline--tRNA ligase  ali model follow..  10  1.......MGSSSSGLVPRGSHMASGAGEGQGPKKQTRLGLEAKKEENLADWYSQVITKSEMIEYHD---------ISGCYILRPWAYAIWEAIKDFFDAEI--KKLGVENCYFPMFVSQSALEKEKTHVADFAPEVAWVTRSG-----------KTELAEPIAIRPTSETVMYPAYAKWVQSHR-DLPIKLNQWCNVVRWEFKHPQ---PFLRTREFLWQEGHSAATMEEAAEEVLQILDLYAQVYEELLAIPVVKGRKTEKEKFAGGDYTTTIEAF--SASGRAIQGGTSHHLGQNFSKMFEIVFEDPKIPGEKQFAYQNSWGLTTRTIGVMTMVHGDNMG------------LVLPPRVACVQVVIIPCGITNEALIAKCNDYRRRLLSVNIRV--RADLRDNYSPGWKFNHWELKGVPIRLEVGPRDMKSCQFVAVRRDTGEKLTVAENEAETKLQAILEDIQV. 427
11 -31.9001nj1_A mol:protein length:501 Proline-tRNA Synthetase  ali model follow..  12  1..............MGSSSSGLVPRGSHMQKPIKKDPNRYHGEKMTEFSEWFHNILEEAEIIDQRYPV--------KGMHVWMPHGFMIRKNTLKILRRILDRDHEEVL----LLVPEDELAKEAIHVKGFEDEVY------------WVTHGGLSKLQRKLALRPTSETVMYPMFALWVRSHT-DLPMRFYQVVNTFRYETKHTR--PLIRVREITTFKEATIHATASEAEEQVERAVEIYKEFFNSLGIP---YLITRRPPWDKFPGSEYTVAFDTLMPDGKTLQIGTVHNLGQTFARTFEIKFETPEGDHEYVHQT--CYGLSDRVIASVIAIHGDESG------------LCLPPDVAAHQVVIVPIKKAAEEVMEACRELRSRLEAAGFRV---HLDDRDIRAGRKYYEWEMRGVPLRVEIGPRDLEKGAAVISRRDTGEKVTADLQGIEETLRELMKDILE. 411
12 -31.5005xip_A mol:protein length:498 Prolyl-tRNA synthetase, putative  ali model follow..  10  6........................................TAKKSTNFADWYTQVIVRGELVEYYD---------ISGCYIIRPWAYRIWEAVQKFFDDGIKRLGVENCYF--MFVSQAKLEKEKDHVEGFKPEVA------------WVTHYGDSELPEKVAIRPTSETIMYPAYAKWIRSHR-DLPLKLNQWNNVVRWEFKQPT---PFLRTREFLWQEGHTAATEEEAYTLVLEILELYRQWYEDYLAVPV-IKGEKSENEKFAGGKKTTTIEGIIPDTGRGIQAATSHLLGQNFSRMFSIEFEDEKGAKQ--LVHQTSWGCTTRSLGVMIMTHGDDKG------------LVLPPRVVAVQAVIIPIIFKETGIVAKCRELERLLNAAGVRVKVD--DRTNYTPGWKFNDWELKGVPLRLEIGPRDVESCQTRVVRRDTSEARNVPWAEAASTIPAMLETMQK. 393
13 -30.9004hvc_A mol:protein length:519 Bifunctional glutamate/proline--tRNA ligase  ali model follow..  5...........................EGQGPKKQTRLGLEAKKEENLADWYSQVITKSEMIEYHD---------ISGCYILRPWAYAIWEAIKDFFDAEI--KKLGVENCYFPMFVSQSALEKEKTHVADFAPEVAWVTRSGK-----------TELAEPIAIRPTSETVMYPAYAKWVQSHR-DLPIKLNQWCNVVRWEFKHP---QPFLRTREFLWQEGHSAATMEEAAEEVLQILDLYAQVYEELLAIPVVKGRKTEKEKFAGGDYTTTIEA---SASGRAIQGGTSHHLGQNFSKMFEIVFEDPKIPGEKQFAYQNSWGLTTRTIGVMTMVHGDNMG------------LVLPPRVACVQVVIIPCGITNEALIAKCNDYRRRLLSVNIRVRAD--LRDNYSPGWKFNHWELKGVPIRLEVGPRDMKSCQFVAVRRDTGEKLTVAENEAETKLQAILEDIQV. 411
14 -30.8004ncx_A mol:protein length:506 Proline--tRNA ligase  ali model follow..  10  9........................................TSKKIENFSDWYTQVIVKSELIEYYD---------ISGCYILRPAAYYIWECVQAFFNKEIKKLNVENSYF--LFVTKNKLEKEKNHIEGFSPEVA------------WVTKYGDSNLPEEIAIRPTSETIMYSVFPKWIRSYR-DLPLKLNQWNTVVRWEFKQPT---PFIRTREFLWQEGHTAKNEEEAVKLVFDILDLYRRWYEEYLAVPIIKGIKSEGEKFGGANFTSTAEAFIS-ENGRAIQAATSHYLGTNFAKMFKIEFEDENEVKQY--VHQTSWGCTTRSIGIMIMTHGDDKG------------LVLPPNVSKYKVVIVPIFYKTTDIHSYCKDIEKILKNAQINCVYD--DRASYSPGYKFNHWELRGIPIRIEVGPKDLQNNSCVIVRRDNNEKCNVKKESVLLETQQMLVDIHK. 396
15 -30.4005xif_A mol:protein length:500 Prolyl-tRNA synthetase (ProRS)  ali model follow..  11  5........................................TAKKDENFSEWYTQAIVRSEMIEYYD---------ISGCYIMRPWAFHIWEKVQRFFDDEIKKMGVENSYF--MFVSRHKLEKEKDHVEGFSPEVA------------WVTHYGDSPLPEKIAIRPTSETIMYPAYAKWIRSHR-DLPLKLNQWCSVVRWEFKQPT---PFLRTREFLWQEGHTAATEEEAWELVLDILELYRRWYEECLAVPVIKGEKSEGEKFAGGKKTTTVE-AFIPENGRGIQAATSHLLGTNFAKMFEIEFEDEEGHK--RLVHQTSWGCTTRSLGVMIMTHGDDKG------------LVIPPRVASVQVVIIPIDENTGEILGKCRELKTMLEKADIRVRID--DRSNYTPGWKYNHWEVKGVPLRLELGPKDLAKGTARVVRRDTGEAYQISWADLAPKLLELMEGIQR. 392
16 -30.0001nj8_A mol:protein length:459 Proline-tRNA Synthetase  ali model follow..  11  1.........................................GSHMLEFSEWYSDILEKAEIYD--------VRYPIKGCGVYLPYGFKIRRYTFEIIRNLL--DESGHDEALFPMLIPEDLLAKEAEHIKGFEDEVY-----------WVTHGGKTQLDVKLALRPTSETPIYYMMKLWVKVHT-DLPIKIYQIVNTFRYETKHTRP---LIRLREIMTFK-TAHSTKEEAENQVKEAISIYKKFFDTLGIP---YLISKRPEWDKFPGAEYTMAFDTIFPDGRTMQIATVHNLGQNFSKTFEIIFETPTGDK--DYAYQTCYGISDRVIASIIAIHGDEKG------------LILPPIVAPIQVVIVPLIFKGKEVMEKAKEIYEKLKGK----FRVHIDDRDIRPGRKFNDWEIKGVPLRIEVGPKDIENKKITLFRRDTMEKFQVDETQLMEVVEKTLNNIME. 384
17 -29.4005f9y_A mol:protein length:511 Aminoacyl-tRNA synthetase  ali model follow..  10  2.............................ASKENESLLGITADKITSFADWYSQVIVKSEMIEYYD---------ISGCYILRPWSYFIWETIQSVFDQKIKQHDVQNAYF--IFVTQKKLETEKDHVEGFSPEVA------------WVTKSGKSDLAEPIAIRPTSETIMYPYFAKWIRSHR-DLPLKINQWTSIVRWEFKHPT---PFIRTREFLWQEGHTASTRKEALEMVDIILNEYASIYEDLLATPVVKGTKSENEKFPGGDITKSIEG----EIGRAVQAATSHLLGQNFSKMFGVEFEDEKGNKEY--AHQTSWGLTTRAIGVMIMTHGDNKG------------LVLPPKVAPVQVIIIPITVITEEQKKICNEVECILKKAGVRV--KIDDRSNYTPGWKYNHWEVKGVCLRFEVGPRDIEKRSVRVVVRDNMEKMDIPISELESKIPKLLEEFQN. 400
18 -28.9002i4l_A mol:protein length:458 Proline-tRNA ligase  ali model follow..  11  12...........................GSHMRLSRFFLPILKENPKEAEIVSHRLMLRAGMLRQEAA----------GIYAWLPLGHRVLKKIEQIVREEQ--NRAGAIELLMPTLQLADLWRESGRYDAYGPEMLR----------------IADRHKRELLYGPTNEEMITEIFRAYIKSYK-SLPLNLYHIQWKFRDEQRPR---FGVMRGREFLMKDAYSFDVDEAARKSYNKMFVAYLRTFARMGLSHEFIVLAETGESGVYIDRDVLNLPVPD-LNTRGIEVGQIFYFGTKYSDSMKANVTGPDGTDAPIHGGSYGVGVSRLLGAIIEACHDDNG-------------IIWPEAVAPFRVTILNLKQGDAATDAACDQLYRELSAKGVDVL---YDDTDQRAGAKFATADLIGIPWQIHVGPRGLAEGKVELKRRSDGARENLALADVVARLT......... 452
19 -27.9003ial_A mol:protein length:518 Prolyl-tRNA synthetase  ali model follow..  11  1..............................MAMGGDVTFSLTKTRDTFADWFDAIMDAAELVDRRYPV--------KGCVVFRPYGFFMENAIMRLCEEEYAKVGISQILF--TVIPESFLKKESDHIKGFEAECF------------WVEKGGLQPLEERLALRPTSETAIYSMFSKWVRSYK-DLPLKIHQTCTIFRHETKNTK---PLIRVREIHWNEAHCCATAEDAVSQLSDYWKVIDTIFSDELCFKGQKLRRVCWDRFPGADYSEVSD-----PCGRVLQTAGIHNLGQRFSSTFDILYANKANESVHPYLT--CAGISTRVLACALSIHGDSGG------------LVLPPLIAPIHVVIIPIGCGKKNNQESDQQVLGKVNESKLGLRVSIDDDFSKSMGDKLYYYELKGVPLRIEVGQRDLANGQCIVVPRDVGKDQKIPITEVMKVSSHTTENHEL. 405
20 -27.1005xil_A mol:protein length:512 Putative prolyl-tRNA synthetase  ali model follow..  5.......................................IAAKREENFSAWYIDVITKAEMIEYYD---------VSGCYIIRPWAYYVWKCVQRFLGGKIEKLGVEDCYF--MFVSRSCLEREKDHIEGFAPEVAWVTRAGD------------TELEQPVAVRPTSETVMYPYYAKWIRSHR-DLPVRLNMWNNVIRWEFSHPT---PFIRTREFLWQEGHCAAKAEECAKEVLEILECYASVYEQLLAVPVVRGRKTEKEKFAGGDYTTTVET---EAVGRGCQGATSHNLGQNFGKMFDIRFQDPENNEQTLIPWQNSWGLSTRVIGVMIMVHGDNRG------------MVMPPRVASTQVIIIPVGITKQELLASCWRLESELCEGGVRA--RCDLRDNYSPGWRFNHWEVKGVPLRVELGPRELAERSLAVAVRHSGARHSVAWDAQTPAAVAALLED... 397
21 -26.7001h4q_A mol:protein length:477 PROLYL-TRNA SYNTHETASE  ali model follow..  15  8.........................................TPQSQDFSEWYLEVIQKAELA----------YGPVRGTIVVRPYGYAIWENIQQVLDRMFKETGHQNAYF--LFIPMSFLRKEAEHVEGFSPELA------------VVTHAGGEELEEPLAVRPTSETVIGYMWSKWIRSWR-DLPQLLNQWGNVVRWEMRTR----PFLRTSEFLWQEGHTAATREEAEEEVRRMLSIYARLAREYAAIPVIEGLKTEKEKFAGAVYTTTIEA----KDGKALQAGTSHYLGENFARAFDIKFQDRDLQVKYVH--TTSWGLSWRFIGAIIMTHGDDRG------------LVLPPRLAPIQVVIVPIDESRERVLEAAQGLRQALLAQGLRV--HLDDRDQHTPGYKFHEWELKGVPFRVELGPKDLEGGQAVLASRLGG-KETLPLAALPEALPGKLDAFHE. 390
22 -26.4002j3l_A mol:protein length:572 PROLYL-TRNA SYNTHETASE  ali model follow..  10.......................................TLREVPNDAEVLSHQILLRAGYIRQVAA----------GIYSYLPLANRVLEKLKTIMREEF--EKIDAVEMLMPALLPAELWKESGRYETYGPNLYR------------------KDRNDRDYILGPTHEETFTELIRDEINSYKRLPLNLYQIQTKYRDEKRSRS---GLLRGREFIMKDGYSFADEASLDQSYRDYEKAYSRIFERCGL-EFRAIIGDGGAMGGKDSKEFMAISEIGEDTICYSTESDYAANLEMATSLYTPKKSHETQLDLEKIALAFTKGIEIGHIFKLGTRYSDAMGATVLDENGREKSVIMPTGIAPFDLHVVQMNVKDEYQTKLSQEVEAMMTEAGYEVL---VDDRNERAGVKFADADLIGCPIRITVGKKAVD-GVVEVKIKRTGEMLEVRKEELESTLSILMNTTSE. 570
23 -24.8005ucm_A mol:protein length:579 Proline--tRNA ligase  ali model follow..  12  12.......................................TLKETPADAVVISHQLLLRAGMIRRLA----------SGLYTWLPMGLRVLRKVETIVREEM--NAAGALEVLMPAVQPAELWQESGRWEQYGPELLR------------------KDRHEREFCVGPTHEEVITDLARNELNSYKQLPINFYQIQTKFRDEIRPR---FGLMRGREFIMKDAYSFLSQDSLQQTYDGMYQAYSKIFSRLGL-DFRPVQADNGSIGGSGSHEFHVLANSGEDDIKTIAALVDGFQLPIEKTIKTLVVHGAEEGTLVALILVIKRGIEVGHIFQLGTKYSEAMKLSVLSEQGKPVNLIMPSALAPFQIALVPLKYETESVKQATDKLYAELTAAGFEVLLD---DKKTSPGVKFADMELIGIPHRIVISDRGLSEGVLEYKGRRDSESQNLPIGELMSFITEKLSR.... 573
24 -21.0001nyq_A mol:protein length:645 threonyl-tRNA synthetase 1  ali model follow..  12  196.............KLLSTAGAYWRGDSNNKMLQRIYGTAFFDKKELKAHLQMLEERKERDHIGKELELFTNSQLVGAGLPLWLPNGATIRREIERYIVD--KEVSMGYDHVYTPVLANVDLYKTSGHWDHYQEDMF---------------PPMQLDETESMVLRPMNCPHHMMIYANKPHSYR-ELPIRIAELGTMHRYEASGA---SGLQRVRGMTLNDSHIFVRPDQIKEEFKRVVNMIIDVYKDFGFEDYSFRLSYRDPEDKEKYFDDDDMWNKAENMLKEAADESTAQLDFLLPERFDLTYIGQDGEHHRPVVIHRGVTMER-FVAFLTEETK-----------------AFPTWLAPKQVQIIPVNVDLH--YDYARQLQDELKSQGVRV---SIDDRNEKMGYKIREAQMQKIPYQIVVGDKEVENNQVNVRQYGSQDQETVEKDEFIWNLVDEIRLKK.. 643
25 -20.9004p3n_A mol:protein length:415 Threonine--tRNA ligase, cytoplasmic  ali model follow..  12  1....................................................MGSSSSGDHIGRDQELYF-FHELSPGSCFFLPKGAYIYNALIEFIRSEY--RKRGFQEVVTPNIFNSRLWMTSGHWQHYSENMFSFEVEKELF-----------------ALKPMNCPGHCLMFDHRPRSWR-ELPLRLADFGVLHRNELSGA---TGLTRVRRFQQDDAHIFCAMEQIEDEIKGCLDFLRTVYSVFGFDIEVWDQAEKQLENSLNEFGEKWELNSGDGAFYG-TIQLDFQLPIRFNLT---YVSHDGDDKKRPVIVHRAISVER-MIAILTENYG-----------------KWPFWLSPRQVMVVPV---GPTCDEYAQKVRQQFHDAKFMA--DIDLDPGCTLNKKIRNAQLAQYNFILVVGEKEKISGTVNIRTRDNKVHGERTISETIERLQQLKEFRS.. 402
26 -20.6004hwt_A mol:protein length:413 Threonine--tRNA ligase, cytoplasmic  ali model follow..  12  23.............................................................................GSCFFLPKGAYIYNALIEFIRSEY--RKRGFQEVVTPNIFNSRLWMTSGHWQHYSENMFSFEVEKELF-----------------ALKPMNCPGHCLMFDHRPRSWR-ELPLRLADFGVLHRNELSGA---TGLTRVRRFQQDDAHIFCAMEQIEDEIKGCLDFLRTVYSVFGFDIEVWDQAEKQLENSLNEFGEKWELNSGDGAFYG-TIQLDFQLPIRFNLT---YVSHDGDDKKRPVIVHRAISVER-MIAILTENYG-----------------KWPFWLSPRQVMVVPV---GPTCDEYAQKVRQQFHDAKFMA--DIDLDPGCTLNKKIRNAQLAQYNFILVVGEKEKISGTVNIRTRDNKVHGERTISETIERLQQLKEFRS.. 398
27 -20.2003a31_A mol:protein length:471 Probable threonyl-tRNA synthetase 1  ali model follow..  4........................................GQDKTHIDYAYELDITVKPDSRVPVFNR---ATFTGAGVPLFSLGGGPIRYALAEVLAKFH--ARRGYYVVETPIIASTELFKVSGHIEFYRNNMYLFDIEGHEF-----------------AVKPMNCPYHILLFLNEVAKHRLPLPFKVFEFGRVHRYEPSGS---YGLLRVRGFTQDDAHIIVPGGRVIDVVYDVFEEMKLVLERLFKSKEEWEGAEEALREAASRINEKYGIDIVELEGEAAFYGPKLDFINLPRRFRLYDVVREEFGIEEVYIIHRALSIER-FLGVYLEHRR-----------------RMPFTLAPIQFAVIAVKTGGREIEDLASSIAKGLLDKGFRV--AVKGSSKTGLSSDVRHIESTAKPANVFIGAKEVREKVLDVRVFDLESMKRRRLAIAYGDAADAVENLA.. 443
28 -19.6004hwo_A mol:protein length:411 Threonine--tRNA ligase  ali model follow..  12  23.............................................................................GMVFWHNDGWTIFRELEVFVRSKL--KEYQYQEVKGPFMMDRVLWEKTGHWDNYKDAMFTTSSENREY-----------------CIKPMNCPGHVQIFNQGLKSYR-DLPLRMAEFGSCHRNEPSGS---HGLMRVRGFTQDDAHIFCTEEQIRDEVNGCIRLVYDMYSTFGFEKIVVKLSTRPEKRIGS---------------DEMWDRAEADLAVALEENNIPFEYQLGEGAFYPKILYDCLDRAWQCGTVQLD--SRLSASYVGEDNERKVPVMIHRALAPVQVVIMNI---TDSQSEYVNELTQKLSNAGIRV---KADLRNEKIGFKIREHTLRRVPYMLVCGDKEVESGKVAVRTRRGKDLGSMDVNEVIEKLQQEIRSRS.. 397
29 -19.2002lw7_A mol:protein length:170 Histidine--tRNA ligase, cytoplasmic  ali model follow..  19  79.......................................................................................................................................................................................................................................................................................................................................................................................KKLLEERLKLVSELQDAGIKA--ELLYKKNPKLLNQLQYCEEAGIPLVAIIGEQELKDGVIKLRSVTSREEVDVRREDLVEEIKRRTGQPLSI 169
30 -17.9003ugq_A mol:protein length:460 Threonyl-tRNA synthetase, mitochondrial  ali model follow..  11  18..............................................ATKNASSATPATMTSMVSQRQDLFMTDPLSPGSMFFLPNGAKIFNKLIE-FMKLQQKFKFGFNEVVTPLIYKKTLWEKSGHWENYADDM--------------FKVETTDEEKEEYGLKPMNCPGHCLIFGKKDRSYN-ELPLRFSDFSPLHRNEASGA---SGLTRLRKFHQDDGHIFCTPSQVKSEIFNSLKLIDIVYNKIFPFVKGGSGAESNYFINFSTRPDHF---------LKVWNHAEQVLKEILEESGKPWKLNPGDGAFYPKLVTDHLRKTHQVATIQLD--ERFDLKFKDQDNSYKRPIMIHRALNPYQAVIIPVNTKNVQQLDMCTALQKPLNDWHFNV---DLDIRNEPVGYRIKSAILKNYSYLIIVGDEEVQLQKYNIRERDNRKSFKLTMSQIWEKFIELEKNYK.. 454
31 -17.8001qf6_A mol:protein length:642 THREONYL-TRNA SYNTHETASE  ali model follow..  11  206...WRGDSNNKMLQRIYGTAWADKKALNAYLQRLEEAAKRDHRKIGKQLDLYH------------------MQEEAPGMVFWHNDGWTIFRELEVFVRSKL--KEYQYQEVKGPFMMDRVLWEKTGHWDNYKDAMFTTSSENREY-----------------CIKPMNCPGHVQIFNQGLKSYR-DLPLRMAEFGSCHRNEPSGS---HGLMRVRGFTQDDAHIFCTEEQIRDEVNGCIRLVYDMYSTFGFEKIVVKLSTRPEKRIGS---------------DEMWDRAEADLAVALEENNIPFEYQLGEGAFYPKILYDCLDRAWQCGTVQLD--SRLSASYVGEDNERKVPVMIHRALAPVQVVIMNI---TDSQSEYVNELTQKLSNAGIRV---KADLRNEKIGFKIREHTLRRVPYMLVCGDKEVESGKVAVRTRRGKDLGSMDVNEVIEKLQQEIRSRS.. 636
32 -14.6001v95_A mol:protein length:130 Nuclear receptor coactivator 5  ali model follow..  12  8..........................................................................................................................................................................................................................................................................................................................................................................PVDCSVIVV---NKQTKDYAESVGRKVRDLGMVV-DLIFLNTEVSLSQALEDVSRGGSPFAIVITQQHQIHRSCTVNIMFGTPQENMPQADAMVLVARNYER.... 107
33 -13.8001qe0_A mol:protein length:420 Histidine--tRNA ligase  ali model follow..  12  6............................................................................RGTQDILPEDSKKWRYIENQLDE--LMTFYNYKEIRTPIFESTDLFARG--------------VGDSTDVVQKEMYTFKDKGDRSITLRPEGTAAVVRSYIEHKMQGNPNQPIKLYYNGPMFRYERKQKG------RYRQFNQFGVEAIGAENPSVD--AEVLAMVMHIYQSFGLKHLKLVINSVGDMASRKEYNEALVKHFEPKTAPRITDFLNEESKAYYEQVKAYLDDLGIPYTEDPNLVRGLDYYTHTAFELMMDNPNYDGAITTLCGGGRYNGLRLLLALEEEGIELDIEENLDDQADRYAVKLLNHLRHNGIKA---DKDYLQRKIKGQMKQADRLGAKFTIVIGDQELENNKIDVKNMTTGESETIELDALVEYFKK........ 420
34 -13.2004g85_A mol:protein length:517 Histidine-tRNA ligase, cytoplasmic  ali model follow..  11  1..GPGSEFELRRQMAERAALEELVKLQGERVRGLKQQKASAELIE----EEVAKLLKLKAQLGPDESKQKFVLKTPKGTRDYSPRQMAVREKVFDVIIR--CFKRHGAEVIDTPVFELKETLMGK--------------------EDSKLIYDLKDQGGELLSLRYDLTVPFARYLAM-----NKLTNIKRYHIAKVYRRDNPAMTRG----RYREFYQCDFDIAGNFDPMIP--AECLKIMCEILSSLQIGDFLVKVNDRREEVKNEMVGEKGLAPEVADRIGDYVQQHGGVSLVEQLLQDPKLSQNKQALEGLGDLIDDKISFDLSLAGVIYEAVLLQTPAQAGEEPLGVGSVRIFSIVEQRLEALEEKIRTTKKLLEERLKLVSELWDAGIKA--ELLYKKNPKLLNQLQYCEEAGIPLVAIIGEQELKDGVIKLRSVTSREEVDVRREDLVEEIKRRTGQP... 516
35 -13.2001wu7_A mol:protein length:434 Histidyl-tRNA synthetase  ali model follow..  10  10............................................................................RGFRDFYPEDMDVEKFIFKTAEE--AAEAFGFRRIDFPSLEYLDLYRIKSGEEL-----------------LQQTYSFVDKGGREVTLIPEATPSTV---RMVTSRKDLQRPLRWYSFPKVWRYEEPQAG------RYREHYQFNADIFGSDSPEAD--AEVIALASSILDRLGLQDI--IIDRYHKISREEFVDQLRSAGIGEDGVSMIADLCSGGIDEMARITGKSSEEIARMAAVEDLLVRYDFSIVRGLTGIVFEAYDRSGQFRAILGGGR-LLLKRENVQIPREKKSVYICRVGKINSSIMNEYSRKLRERGMNV---TVEIMERGLSAQLKYASAIGADFAVIFGERDLERGVVTIRNMYTGSQENVGLDSVVEHLISQATLE... 428
36 -12.9003net_A mol:protein length:465 Histidyl-tRNA synthetase  ali model follow..  10  16............................................................................SGFPEFLPSEKRLELYLLDTIRR--VYESYGFTPIETPAVERLEVLQAKGNQG---DNIIYGLEPILPPNRQAEKDKSGDTGSEARALKFDQTVPLAAYI--ARHLNDLTFPFARYQMDVVFRGERAKDG------RFRQFRQCDIDVVGREKLSLLYDAQMPAIITEIFEAVNIGDFVIRINNLEKIGEAKVKLELEKEGINPEQTQKIIDGSVDDVLDKLKHLSQTLPESEQFNLGVSELFCIDLAIARGLNYYTGTVYETTLIGHEALGGLTRLISRLLKA-TPAQVVVVNM---QDELMPTYLKVSQQLRQAGLNV---ITNFEKRQLGKQFQAADKQGIRFCVIIGADEAAAQKSSLKDLQSGEQVEVALADLAEEIKRRLT..... 465
37 -12.6003hrk_A mol:protein length:456 Histidyl-tRNA synthetase  ali model follow..  27............................................................................QGCRDFPPEAMRCRRHLFDVFHA--TAKTFGFEEYDAPVLESEELYIRKAGEEI-----------------TEQMFNFITKGGHRVALRPEMTPSLARLL--LGKGRSLLLPAKWYSIPQCWRYEAITRG------RRREHYQWNMDIVGVKSVSAE--VELVCAACWAMRSLGLSSKDVGIKIVDKMEKIPREEVEAQLAVLGLEPTVVDAITTTLSLKSIDEIAQRVGEEHEAVKELRQFYGDWVLFDASVVGIVFEGFDREGKFRALCGGGRYDNLVIVELLQEKRLLPDIPHVVDESMRPHALAVLRRLRDAGRSA---DIILDKKKVVQAFNYADRVGAVRAVLVAPEEWERGEVQVKMLREGTGKEEGGAERGFAVPL........ 446
38 -12.3005e3i_A mol:protein length:438 Histidine--tRNA ligase  ali model follow..  10............................................................................KGFNDVLPTQTAAWRRLEQHLAS--LMDAYGYQQIRLPIVEQTGLFKRA--------------DATDIVEKEMYTFFDKGNPPESLTLRPEGTAGCVRAL--VEHNLLRGATPRVWYMGPMFRYEKPQKG------RYRQFHQFGVETFLNTLGETDERTEYRNALVAFLNQRRLTTNPLRILDSKIESTQKILE----------NAPKLHDFLKEDSLSHFQQLQDYLTAAGIKFVINQKLVRGLDYYNKTVFEWTTTALGSQGTVCAGGRGMERLLLLLEQVQAEIVRDCEAFLVAEPAYQSKALVLAEQLRDQLEAA-IRIKTGSQGSMKSQMKKADQAGAVYAIILGEREWEAQQLAVKELATAEQSQVALAELVPFLIEKFTK.... 432
39 -12.1003hri_A mol:protein length:456 Histidyl-tRNA synthetase  ali model follow..  27............................................................................QGCRDFPPETMRLRKYLFDVFHS--TARKFGFEEYDSPVLESEELYIRKAGEEI-----------------TEQMFNFITKGGHRVALRPEMTPSLARQL--LAKGRSLLLPAKWYSIPQCWRYEAITRG------RRREHYQWNMDIIGVKSVSSE--VELVCAACTAMQSLGLSSKDVGVKKMEKLPREEVVAQLAAIGLESNVVDAITSTLSLTIDEIAQRIGEEHEAVRELRDFITQIFGDWVIFDASVVGIVFEGFDRDGNFRALCGGGRYDNLVIVELLNEKKLLPELHHVVDETMRPHALSILRRLRDAGRSA---DIVFDKKKVVQAFNYADRIGALRAVLVAPDEWARGEVRVKMLREGAGREEGANERGIVLPV........ 446
40 -11.9003qne_A mol:protein length:485 Seryl-tRNA synthetase, cytoplasmic  ali model follow..  155....................................................HEVLLRLDGY----DPERGVRIVGHRGYFLRNYGVFLNQALINYGLSFLS--SKGYVPLQAPVMMNKEVMAKTAQLSQFDEELYK----------------VIDGEDEKYLIATSEQPISAYHAGEWFESPAEQLPVRYAGYSSCFRREAGSHKDAWGIFRVHAFEKIEQFVLTEPEKSWEEFDRMIGCSEEFYQSLGLP---YRVVGIVSGELNNAAAKKYDLE-EYKELVSCSNCTDYQSRNLE---RCGIKQQNQQEKKYVHCLNSTLSATERTICCILENYQKEDG------------LVIPEVLRKY-------IPGEPEFIPYIKELPKNTTSVKKAK-------------------------------GKNPKNTTSVKKAKGKNGSR..................... 479
41 -11.4004e51_A mol:protein length:467 Histidine--tRNA ligase  ali model follow..  30............................................................................KGMNDILPQDAGLWEFFEATVKS--LLRAYGYQNIRTPIVEHTPLFTRG---------------EVTDIVEKEMYSFVDALNGENLTLRPENTAAVVRAA--IEHNMLYDGPKRLWYIGPMFRHERPQRG------RYRQFHQVGVEALGFAGPDAD--AEIVMMCQRLWEDLGLTGIKLEINSLGLAEERAAHRVELI-----RNAPKLIDFLGDVSRAHFEGLQRLLKANNVPFTINPRLVRGLDYYNLTVFEWVTDKLGAQGTVAAGGRGIERILELLKEEVPEQEGVDVYVVHQGDAAREQAFIVAERLRDTGLDVILHCSADAGASFKSQMKRADASGAAFAVIFGEDEVTNGTASVKPGEKSVQQSVPVESLTEFLINAMVATAE. 457
42 -11.3004h2w_A mol:protein length:346 Amino acid--[acyl-carrier-protein] ligase 1  ali model follow..  5.......................SSGLVPRGSHMNIAVLPNSPDTAPQIADPLDHLADKLFHSMGSD----------GVYARTALYESIVERLAALITS---HREAGTEALRFPPVMSRAQLEKSGYLKSFPNLLGEREINAAVSRFDAGGDWTTSLSPADLVLSPAACYPVYPIAAS--RGPLPKGGLRFDVAADCFRRE-----PSKHLDRLQSFRMREYVCIGTPDDVSDFRERWMVRAQAIARDLGASDPFFGRAGKMLANNQRDQQLKFELLIPLRSEEQPTACMSFNYHREHFGTTWGIQDANGEPAHTGCV---AFGMDRLAVAMF----HTHGTDLSAWPAKVRDILGLQPHVAAGAHG..................................................................................................... 336
43 -11.3004g84_A mol:protein length:464 Histidine--tRNA ligase, cytoplasmic  ali model follow..  11  18............................................................................KGTRDYSPRQMAVREKVFDVIIR--CFKRHGAEVIDTPVFELKETLMGK--------------------EDSKLIYDLKDQGGELLSLRYDLTVPFARYLAM-----NKLTNIKRYHIAKVYRRDNPAMTRG----RYREFYQCDFDIAGNFDPMIP--AECLKIMCEILSSLQIGDFLVKVNDRRILDGMTLFGIDDKISFDLSLARGLDYYTGVIYEAVLLQTPAQVGMFDPKGRKVPCV---SIGVERIFSIV----------------EQRLEALEEKIRTTETQVLVASA---QKKLLEERLKLVSELWDAGIKA--ELLYKKNPKLLNQLQYCEEAGIPLVAIIGEQELKDGVIKLRSVTSREEVDVRREDLVEEIKRRTGQP... 463
44 -10.8003mey_A mol:protein length:346 Bll0957 protein  ali model follow..  10  10............................PRGSHMNIAVLPNSPDTAPQIADPLDHLADKLFHSMGSD----------GVYARTALYESIVERLAALITS---HREAGTEALRFPPVMSRAQLEKSGYLKSFPNLLGEREINAAVSRFDAGGDWTTSLSPADLVLSPAACYPVYPIAAS--RGPLPKGGLRFDVAADCFRRE-----PSKHLDRLQSFRMREYVCIGTPDDVSDFRERWMVRAQAIARDLGASDPFFGRVGQMKAVSQKQQQLKFELLIPLRSEEQPTACMSFNYHREHFGTTWGIQDANGEPAHTGCV---AFGMDRLAVAMF----HTHGTDLSAWPAKVRDILGLQPHVAA......................................................................................................... 332
45 -10.7004rdx_A mol:protein length:423 Histidine--tRNA ligase  ali model follow..  10  9............................................................................RGTKDLFGKELRMHQRIVATARK--VLEAAGALELVTPIFEETQVFEKG--------------VGAATDIVRKEMFTFQDRGGRSLTLRPEGTAAMVRAYLE--GMKVWPQPVRLWMAGPMFRAERPQKG------RYRQFHQVNYEALGSENPILD--AEAVVLLYECLKELGLRRLKVKLSSVGDPEDRARYNLDSKSERDQALLKELGVRPMLDFLGEEARAHLKEVERHLERLSVPYELEPALGLDYYVRTAFEVHHEEIGAQSALGGGGRYDGLRVALALEAEGFGLPEEKGPDEEAVAEAFYLAEALRPR----LRAEYALAPRKPAKGLEEALKRGAAFAGFLGEDELRAGEVTLKRLATGEQVRLSREEVPGYLLQALG..... 423
46 -10.4002el9_A mol:protein length:431 Histidyl-tRNA synthetase  ali model follow..  11  16............................................................................RGMNDYLPGETAIWQRIEGTLKN--VLGSYGYSEIRLPIVEQTPLFKRA--------------IGEVTDVVEKEMYTFEDRNGDSLTLRPEGTAGCVRAG--IEHGLLYNQEQRLWYIGPMFRHERPQKG------RYRQFHQLGCEVFLNSIGSLEARANYRDALVAFLEKRRMYTNPLRVLDSKNPEVQALLN----------DAPALGDYLDEESREHFAGLCKLLESAGIAYTVNQRLVRGLDYYNRTVFEWVTNSLGSQGTVCAGGRGLERLVLLVQAVFKADPVVDIYLVASGADTQSAAMALAERLRDELPGV-KLMTNHGGGNFKKQFARADKWGARVAVVLGESEVANGTAVVKDLRSGEQTAVAQDSVAAHLRTLLG..... 431
47 -10.3002cim_A mol:protein length:522 SERYL-TRNA SYNTHETASE  ali model follow..  148.....EVGEAEMKNRVPDRILTLLEEKIEAAQYGAKAEHQREPMEHPFKEDPTQAMMKEGWLKRGSS---------RGQWIHGPQSARIFRTFEKIVLEELL-EPLGYREMIFPKLVTWEVWMKSGHAKGVYPEIYEVADYYKVTHEVPTKLIKEKIAEPIGGMCYAQCPPFWMYVAG-ETLPNEEIPVKVFDRGTSHRYESGGIH---GIERVDEFHRIEIVWIGTKEEVLKCAEELHDRYMHIFNDILDIEWRKARVTLAEENTVGTTDYEACLPYRGPDGEWLEFQN---VSINGDKYPKGFNVKLQSGDEL-----SGVGLERWAAVFLAQ..................................................................................................................................... 490

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Awobuluyi M, Yang J, Ye Y, Chatterton JE, Godzik A, Lipton SA, Zhang D. Subunit-specific roles of glycine-binding domains in activation of NR1/NR3N-methyl-D-aspartate receptors. Mol Pharmacol. 2007 Jan;71(1):112-22. Epub 2006 Oct 17.