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Query: 3lsq_A mol:protein length:484 Seryl-tRNA synthetase, from PDB1018

Results of FFAS03 search in PDB1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst GPGSMMVLDIQLFRDETGANIIRESQRRRFADPDIVDAIIEADKKWRRTQFLTEASKKLINICSKAVGAKKKAKEADGDTSEIPPQVKEAYENGTLKGEQVEQLCVLQLKQLSKDLSDQVAGLAKEAQQLEEERDKLMLNVGNILHESVPIAQDEETGNTVVRTFGNTTKRAKLNHVSIMERLGMMDTSKAVTSMAGGRSYVLKGGLVQLQVALVSYSLDFLVKRGYTPFYPPFFLNRDVMGEVAQLSQFDEELYQVSGDGDKKYLIATSEMPIAAYHRGRWFTELKEPLKYAGMSTCFRKEAGAHGRDTLGIFRVHQFDKIEQFVVCSPRQEESWRHLEDMITTSEEFNKSLGLPYRVVNICSGALNNAAAKKYDLEAWFPASGAFRELVSCSNCTDYQSQSVNCRYGPNLRGTAAQNVKEYCHMLNGTLCAITRTMCCICENYQTEEGVVIPDVLRPYMMGIEMIRFENNAQAEGTTPDKGELast
1 -136.0003lsq_A mol:protein length:484 Seryl-tRNA synthetase  ali model  100  1GPGSMMVLDIQLFRDETGANIIRESQRRRFADPDIVDAIIEADKKWRRTQFLTEASKKLINICSKAVGAKKKAKEADGDTSEIPPQVKEAYENGTLKGEQVEQLCVLQLKQLSKDLSDQVAGLAKEAQQLEEERDKLMLNVGNILHESVPIAQDEETGNTVVRTFGNTTKRAKLNHVSIMERLGMMDTSKAVTSMAGGRSYVLKGGLVQLQVALVSYSLDFLVKRGYTPFYPPFFLNRDVMGEVAQLSQFDEELYQVSGDGDKKYLIATSEMPIAAYHRGRWFTELKEPLKYAGMSTCFRKEAGAHGRDTLGIFRVHQFDKIEQFVVCSPRQEESWRHLEDMITTSEEFNKSLGLPYRVVNICSGALNNAAAKKYDLEAWFPASGAFRELVSCSNCTDYQSQSVNCRYGPNLRGTAAQNVKEYCHMLNGTLCAITRTMCCICENYQTEEGVVIPDVLRPYMMGIEMIRFENNAQAEGTTPDKGE 484
2 -125.0003vbb_A mol:protein length:522 Seryl-tRNA synthetase, cytoplasmic  ali model follow..  48  1.....MVLDLDLFRVDKDPALIRETQEKRFKDPGLVDQLVKADSEWRRCRFRADNLNKLKNLCSKTIGEKMKKKEPVGDDESVPENVLSFDD---LTADALANLKVSQIKKVRLLIDEAILKCDAERIKLEAERFENLREIGNLLHPSVPISNDEDVDNKVER-IWGDCTVRKKYSHVDLVVMVDGFEGEKGAVVAGSRGYFLKGVLVFLEQALIQYALRTLGSRGYIPIYTPFFMRKEVMQEVAQLSQFDEELYKVDNSYDEKYLIATSEQPIAALHRDEWLRPEDLPIKYAGLSTCFRQEVGSHGRDTRGIFRVHQFEKIEQFVYSSPHDNKSWEMFEEMITTAEEFYQSLGIPYHIVNIVSGSLNHAASKKLDLEAWFPGSGAFRELVSCSNCTDYQARRLRIRYGQTKKM---MDKVEFVHMLNATMCATTRTICAILENYQTEKGITVPEKLKEFMPPGLLIPFVKPAPIEQEPSKKQK 485
3 -124.0006blj_A mol:protein length:485 Serine-tRNA ligase  ali model follow..  49  2.....AMLDINLFREYKNPEIIRESQRRRFADVTLVDKVIELDEVWRATIGKLNHIKSFTGIISKEVGNRMKNKVPLGDDLELPKEVTDFTKEALEQGSLAKLNTNQLKKLSTYITEVHIKNSEEEVKQKEKERDDVLLQIGNIVHETVVVSDNEDNNGIVRMVGNDPETGYKCLKHIDIMRKLGGLATEEGTQVGGGRGYFLLGDLVRMNLALQNYAIDFLAKKGYMPIYTPFFMTKEQMKKVAQLSQFDEELYTVTGEGEDKYLIATSEQPIAAFHLEKRFDESELPIKYCGMSTCFRKEVGAHGKDTLGIFRVHQFEKIEQFVVTSPKDNKSWEMFDEMIGNSEAFYQSLGIPYRVVNIVSGALNNAAAKKFDLEAWFPGGNEYRELVSCSNCTDYQTRRLEVKYGKSK---KQGSEVEFCHMLNSTLTATSRTLCCIVENYQTPEGVNVPEVLQPYMGGTKFIKFKN............. 479
4 -119.0001wle_A mol:protein length:501 Seryl-tRNA synthetase  ali model follow..  23  28GYSALPLLDMESLCAY--PEDAARALDLRKGELRSLPGIISTWQELRQLREQIRSLEEEKEAVTEAVRALVVNQDNSQVQ---------------------QDPQYQSLRARGREIRKQLTLLYPKEAQLEEQFYLRALRLPNQTHPDVPVGDESQ-ARVLHVVGDKPAFSFQPRGHLEIAEKLDIIRQKRLSHVSGHRSYYLRGAGALLQHGLVNFTLNKLIHRGFTPMTVPDLLRGVVFEGCGMTPNAKPSQIYNPSRFEDLNLAGTAEVGLAGYFMDHSVAFRDLPIRMVCSSTCYRAETD-TGKEPWGLYRVHHFTKVEMFGVTGPGLEQSSELLEEFLSLQMEILTELGLHFRVLDMPTQELGLPAYRKFDIEAWMPGRGRFGEVTSASNCTDFQSRRLHIMFQTEAG------ELQFAHTVNATGCAVPRLLIALLESYQQKDGVLVPPALQPYLGTDRITTPTHVPLQYIGPNQPQK 485
5 -117.0002dq0_A mol:protein length:455 Seryl-tRNA synthetase  ali model follow..  34  1......MLDIKLIREN--PELVKNDLIKRGEKVKWVDEILKLDTEWRTKLKEINRLRHERNKIAVEIGKRRKKGE-----------------------------PVDELLAKSREIVKRIGELENEVEELKKKIDYYLWRLPNITHPSVPVGKDENDNVPIRFWGEYEILEWKPKLHVDLLEILGGADFARAAKVSGSRFYYLLNEIVILDLALIRFALDRLIEKGFTPVIPPYMVRRFVEEGSTSFEDFEDVIYKV--EDEDLYLIPTAEHPLAGMHANEILDGKDLPLLYVGVSPCFRKEAGTAGKDTKGIFRVHQFHKVEQFVYS--RPEESWEWHEKIIRNAEELFQELEIPYRVVNICTGDLGYVAAKKYDIEAWMPGQGKFREVVSASNCTDWQARRLNIRFRDRT-----DEKPRYVHTLNSTAIATSRAIVAILENHQEEDGVRIPKVLWKYTGFKEIVPVEKKERCCAT...... 455
6 -114.0002dq3_A mol:protein length:425 Seryl-tRNA synthetase  ali model follow..  33  1......MIDINLIREK--PDYVKERLATRDKELVLVDKVLELDKRRREIIKRLEALRSERNKLSKEIGKLKREGK-----------------------------DTTEIQNRVKELKEEIDRLEEELRKVEEELKNTLLWIPNLPHPSVPVGEDEKDNVEVRRWGEPRKFDFEPKPHWEIGERLGILDFKRGAKLSGSRFTVIAGWGARLERALINFMLDLHTKKGYKEICPPHLVKPEILIGTGQLPKFEEDLYKC--ERDNLYLIPTAEVPLTNLYREEILKEENLPIYLTAYTPCYRREAGAYGKDIRGIIRQHQFDKVELVKIV--HPDTSYDELEKLVKDAEEVLQLLGLPYRVVELCTGDLGFSAAKTYDIEVWFPSQNKYREISSCSNCEDFQARRMNTRFKDSK-----TGKNRFVHTLNGSGLAVGRTLAAILENYQQEDGVVVPEVLRDYVGTDVIRPE............... 425
7 -112.0001ser_A mol:protein length:421 PROTEIN (SERYL-TRNA SYNTHETASE (E.C.6.1.1.11))  ali model follow..  25  1......MVDLKRLRQE--PEVFHRAIREKGVALD-LEALLALDREVQELKKRLQEVQTERNQVAKRVPKAPPEEK-------------------------------EALIARGKALGEEAKRLEEALREKEARLEALLLQVPLPPWPGAPVGGEEANREIKRVGGPP--EFSFPPLDHVALMEKNGWWEPRISQVSGSRSYALKGDLALYELALLRFAMDFMARRGFLPMTLPSYAREKAFLGTGHFPAYRDQVWAI--AETDLYLTGTAEVVLNALHSGEILPYEALPLRYAGYAPAFRSEAGSFGKDVRGLMRVHQFHKVEQYVLTEASLEASDRAFQELLENAEEILRLLELPYRLVEVATGDMGPGKWRQVDIEVYLPSEGRYRETHSCSALLDWQARRANLRYRDPEG------RVRYAYTLNNTALATPRILAMLLENHQLQDGVRVPQALIPYMGKEVLEPC............... 420
8 -109.0003qne_A mol:protein length:485 Seryl-tRNA synthetase, cytoplasmic  ali model follow..  43  1......MLDINAFLVEKDPEIIKASQKKRGDSVELVDEIIAEYKEWVKLRFDLDEHNKKLNSVQKEIGKRFKAKE-----------------------------DAKDLIAEKEKLSNEKKEIIEKEAEADKNLRSKINQVGNIVHESVVDSQDEENNELVRTWTPEATGAPAKLSHHEVLLRLDGYDPERGVRIVGHRGYFLRNYGVFLNQALINYGLSFLSSKGYVPLQAPVMMNKEVMAKTAQLSQFDEELYKVIDGEDEKYLIATSEQPISAYHAGEWFESEQLPVRYAGYSSCFRREAGSHGKDAWGIFRVHAFEKIEQFVLTE--PEKSWEEFDRMIGCSEEFYQSLGLPYRVVGIVSGELNNAAAKKYDLEAWFPFQQEYKELVSCSNCTDYQSRNLEIRCGIKQQN---QQEKKYVHCLNSTLSATERTICCILENYQKEDGLVIPEVLRKYIPGEPEFIPYIKELPKNTTSVKKA 458
9 -108.0003err_A mol:protein length:536 fusion protein of microtubule binding domain from mouse cytoplasmic dynein and seryl-tRNA synthetase from Thermus thermophilus  ali model follow..  24  110........QIRSIIMR--ENFIPTIVNFSAEEIS-DAIREKMKKNYMSNPSYNYEIVNRASLAAGPMVKWAIAQL-----------------------------NYADMLKRVEPLRNELQKLEDDAKDNQQKLEALLLQVPLPPWPGAPVGGEEANR-EIKRVGGPPEFSFPPLDHVALMEKNGWWE-PRISQVSGSRSYALKGDLALYELALLRFAMDFMARRGFLPMTLPSYAREKAFLGTGHFPAYRDQVWAI--AETDLYLTGTAEVVLNALHSGEILPYEALPLRYAGYAPAFRSEAGSFGKDVRGLMRVHQFHKVEQYVLTEASLEASDRAFQELLENAEEILRLLELPYRLVEVATGDMGPGKWRQVDIEVYLPSEGRYRETHSCSALLDWQARRANLRYRDPEG------RVRYAYTLNNTALATPRILAMLLENHQLQDGVRVPQALIPYMGKEVLEPG............... 529
10 -59.5003w3s_A mol:protein length:527 Type-2 serine--tRNA ligase  ali model follow..  13  17VDPAEIEPTVEEFVKEANEDLLQRGVPTGKEGAKILYDTIYMEITGTRYLRPHEAAMRVRKRLAERLGRKHRVGVRDLKIPRYEVVLRFDREVTY---------DYVGYVPVADDVVVEDGTVRLTFQDVDEERRHVIDRVIRLVAWAVEERSELVERVTKVEPGTVVDESGPRRIRFRGDVTEEARRRGWVKEFPGRGQWIYTPPMAALFEVLRDFLLERVTRKGFEPALFPKLIPLETMFRMRYLHGLPDGMYYVCPRDPGYVLAPAQCEPFYELLRDEVVDPERLPIKYDCSGWTYRWEGGA----AKGLERVNEFQRIEHVWIA--EPEEAYRIRRELLEATKRVAEELELEWKVVLLEDRDIELPDVPSYEFEVYLPFKGERSSEEAWISVGSFNVHGEHFVDG------NVKEKSGRTLFTGCAGLGVTRWVVGLLAQHGFYPYEPILERIDEKFGGLPEVPKTLTWPE......... 527
11 -43.3004h2w_A mol:protein length:346 Amino acid--[acyl-carrier-protein] ligase 1  ali model follow..  12  1............................................................................................................................................MGSSSSGLVPRGSHMNIAVL----------PNSPDTAPQIADPLDHLADKLFHSMGSDGVYARTALYESIVERLAAL-ITSHREAGTEALRFPPVMSRAQLEKSGYLKSFPNLLGCVCGSPADLVLSPAACYPVYPIAASRGPLPKG-GLRFDVAADCFRRE------PSKHLDRLQSFRMREYVCIGT--PDDVSDFRERWMVRAQAIARDLGLTFRVDYASLANNQRDQQLKFELLIPLRSEEQPTACMSFNYHREHFGTTWGIQDANG----------EPAHT-GCVAFGMDRLAVAMFHTHGT-DLSAWPAKVRDILGLQPHVAAGAHG........... 336
12 -43.2003mey_A mol:protein length:346 Bll0957 protein  ali model follow..  12  1............................................................................................................................................MGSSSSGLVPRGSHMNIAVL----------PNSPDTAPQIADPLDHLADKLFHSMGSDGVYARTALYESIVERLAALITS-HREAGTEALRFPPVMSRAQLEKSGYLKSFPNLLGCVCLSPADLVLSPAACYPVYPIAASRGPLPKG-GLRFDVAADCFRRE------PSKHLDRLQSFRMREYVCIGT--PDDVSDFRERWMVRAQAIARDLGLTFRVDYASKAVSQKQQQLKFELLIPLRSEEQPTACMSFNYHREHFGTTWGIQDANG----------EPAHT-GCVAFGMDRLAVAMFHTHGT-DLSAWPAKVRDILGLQPHVAAGA............. 334
13 -33.1002cim_A mol:protein length:522 SERYL-TRNA SYNTHETASE  ali model follow..  14  42.........FEEANSTLLTRGAPEGQGAKVTEWKLGEDRIELTLQSGRYVRVHDAIFRLRKQLAEALGKKYKIGIRGIEVESFIIKVPADHELRMLKVPYIKSMENIE--------GIQLELEVGEAEMKNRVPDRILTLLEEKIEAAQYGAKAEHWNLLWQREPMEHPFKEDPTQ--------AMMKEGWLKRGSSRGQWIHGPQSARIFRTFEKIVLEELLEPGYREMIFPKLVTWEVWMKSGHAKGVYPEIYYVKIAEPIGGMCYAQCPPFWMYVAGETLPNEEIPVKVFDRGTSHRYESGG----IHGIERVDEFHRIEIVWIGT--KEEVLKCAEELHDRYMHIFNDILDIEWRKARVTGLAEENTVGTTDYEACLPPDGEWLEFQNVSINGDKYPKGFNVKLQSG----------DELWS-GCSGVGLERWAAVFLAQKGL-DPANWPEEFRNRVGEMP................... 510
14 -24.0002i4l_A mol:protein length:458 Proline-tRNA ligase  ali model follow..  13  12.......................................................................................................................................................GSHMRLSRFFLPILKENPKEAEIVSHRLMLRAGMLRQEAAGI-------YAWLPLGHRVLKKIEQIVREEQNRAGAIELLMPTLQLADLWRESGRYDAYGPEMLRIADHKRELLYGPTNEEMITEIFRAYIKSYKSLPLNLYHIQWKFRDEQ----RPRFGVMRGREFLMKDAYSFDVDE-AGARKSYNKMFVAYLRTFARMGLKAIPMRAETGPIGGDLSH----EFIVLAETGESGVYIDRDVLIFYSDSMKANVTGPDGTDAP--------HGGSYGVGVSRLLGAIIEACHDDNGIIWPEAVAPF........................ 360
15 -22.4004k86_A mol:protein length:535 Proline--tRNA ligase  ali model follow..  12  8...........................................................................................................................................LVPRGSHMASGAGEGQGPKKQTRLGLEAKKEENLADWYSQVITKSEMIEYH---DISG--CYILRPWAYAIWEAIKDFFDAEIKKLGVENCYFPMFVSQSALEKEKTHVADFAPEVAWTELAEPIAIRPTSETVMYPAYAKWVQSHRDLPIKLNQWCNVVRWEF----KHPQPFLRTREFLWQEGHSAFATM-EEAAEEVLQILDLYAQVYEELLAIPVVKGRKTEEKFAGGDYTTTIEAFISASGRAIQGGTSHHLGQNFSKMFEIVFEDPKI------PGEKQFAYQNSWGLTTRTIGVMTMVHGDNMGLVLPPRVACV........................ 319
16 -22.3004hvc_A mol:protein length:519 Bifunctional glutamate/proline--tRNA ligase  ali model follow..  12  1....................................................................................................................................................MGSGEGQGPKKQTRLGLEAKKEENLADWYSQVITKSEMIEYH---DISG--CYILRPWAYAIWEAIKDFFDAEIKKLGVENCYFPMFVSQSALEKEKTHVADFAPEVAWTELAEPIAIRPTSETVMYPAYAKWVQSHRDLPIKLNQWCNVVRWEF----KHPQPFLRTREFLWQEGHSAFA-TMEEAAEEVLQILDLYAQVYEELLAIPVVKGRKTEEKFAGGDYTTTIEAFISASGRAIQGGTSHHLGQNFSKMFEIVFEDPKIP----GEKQFAYQNS----LTTRTIGVMTMVHGDNMGLVLPPRVACV........................ 303
17 -21.0004ncx_A mol:protein length:506 Proline--tRNA ligase  ali model follow..  13  11.......................................................................................................................................................................KKIENFSDWYTQVIVKSELIEY---YDISG--CYILRPAAYYIWECVQAFFNKEIKKLNVENSYFPLFVTKNKLKEKNHIEGFSPEVAWVTKYPEEIAIRPTSETIMYSVFPKWIRSYRDLPLKLNQWNTVVRWEF----KQPTPFIRTREFLWQEGHTAHKNE-EEAVKLVFDILDLYRRWYEEYLAVPIIKIKSEGEKFGGANFTSTAEAFISENGRAIQAATSHYLGTNFAKMFKIEFEDENEVKQYVHQTSW---------CTTRSIGIMIMTHGDDKGLVLPPNVSKY........................ 292
18 -20.8005xil_A mol:protein length:512 Putative prolyl-tRNA synthetase  ali model follow..  13  17................................................................................................................................................................................YIDVITKAEMIEYY-----DVSGCYIIRPWAYYVWKCVQRFLGGKIEKLGVEDCYFPMFVSRSCLREKDHIEGFAPEVAWVTRAEQPVAVRPTSETVMYPYYAKWIRSHRDLPVRLNMWNNVIRWEF----SHPTPFIRTREFLWQEGHCAWAKA-EECAKEVLEILECYASVYEQLLAVPVVRGRKTEEKFAGGDYTTTVETFIEAVGRGCQGATSHNLGQNFGKMFDIRFQDPEN------NEQTLIPWQNSWGLSTRVIGVMIMVHGDNRGMVMPPRVAST........................ 291
19 -20.7005f9y_A mol:protein length:511 Aminoacyl-tRNA synthetase  ali model follow..  14  15.......................................................................................................................................................................DKITSFADWYSQVIVKSEMIEY---YDISG--CYILRPWSYFIWETIQSVFDQKIKQHDVQNAYFPIFVTQKKLTEKDHVEGFSPEVAWVTKSAEPIAIRPTSETIMYPYFAKWIRSHRDLPLKINQWTSIVRWEF----KHPTPFIRTREFLWQEGHTAHSTR-KEALEMVDIILNEYASIYEDLLATPVVKGTKSEEKFPGGDITKSIEGFIPEIGRAVQAATSHLLGQNFSKMFGVEFEDEKGNKEYAHQTSW---------LTTRAIGVMIMTHGDNKGLVLPPKVAPV........................ 296
20 -20.7001nj8_A mol:protein length:459 Proline-tRNA Synthetase  ali model follow..  14  1......................................................................................................................................................................GSHMLEFSEWYSDILEKAEIYDVRY--PIKG--CGVYLPYGFKIRRYTFEIIRNLLDESGHDEALFPMLIPEDLLAKEAEHIKGFEDEVYWTQLDVKLALRPTSETPIYYMMKLWVKVHTDLPIKIYQIVNTFRYET----KHTRPLIRLREIMTFKEAHTAHSTKEEAENQVKEAISIYKKFFDTLGIPYLISKRPEWDKFPGAEYTMAFDTIFPDGRT--QIATVHNLGQNFSKTFEIIFETPTGDKD--------YAYQTCYGISDRVIASIIAIHGDEKGLILPPIVAPI........................ 283
21 -20.3003ial_A mol:protein length:518 Prolyl-tRNA synthetase  ali model follow..  15  12......................................................................................................................................................................TKTRDTFADWFDAIMDAAELVDRRY--PVKGC--VVFRPYGFFMENAIMRLCEEEYAKVGISQILFPTVIPESFLKESDHIKGFEAECFWVEKGGLQLALRPTSETAIYSMFSKWVRSYKDLPLKIHQTCTIFRHET----KNTKPLIRVREIHWNEAHCCHATA-EDAVSQLSDYWKVIDTIFSDELCFKGQKLRRVCWDRFPGADYSEVSDVVMPCGRVLQTAGIHNLGQRFSSTFDILYANKANESV--------HPYLTCAGISTRVLACALSIHGDSGGLVLPPLIAPI........................ 294
22 -20.1005xip_A mol:protein length:498 Prolyl-tRNA synthetase, putative  ali model follow..  14  6.....................................................................................................................................................................TAKKSTNFADWYTQVIVRGELVEY---YDISG--CYIIRPWAYRIWEAVQKFFDDGIKRLGVENCYFPMFVSQAKLKEKDHVEGFKPEVAWVTHYPEKVAIRPTSETIMYPAYAKWIRSHRDLPLKLNQWNNVVRWEF----KQPTPFLRTREFLWQEGHTAHATE-EEAYTLVLEILELYRQWYEDYLAVPVIKGEKSENEKFAGGKKT-IEGIIPDTGRGIQAATSHLLGQNFSRMFSIEFEDEKGAKQ--------LVHQTSWGCTTRSLGVMIMTHGDDKGLVLPPRVVAV........................ 289
23 -19.8001h4q_A mol:protein length:477 PROLYL-TRNA SYNTHETASE  ali model follow..  12  1...............................................................................................................................................................MAKEKGLTPQSQDFSEWYLEVIQKAELADYG---PVRGT--IVVRPYGYAIWENIQQVLDRMFKETGHQNAYFPLFIPMSFLKEAEHVEGFSPELAVVEELEEPLAVRPTSETVIGYMWSKWIRSWRDLPQLLNQWGNVVRWEM-----RTRPFLRTSEFLWQEGHTAHATR-EEAEEEVRRMLSIYARLAREYAAIPVIEGLKTEEKFAGAVYTTTIEALMKDGKA--QAGTSHYLGENFARAFDIKFQDRDLQVKYVHTTSW---------LSWRFIGAIIMTHGDDRGLVLPPRLAPIQ--VVIVPIYKDESRERVLEAAQG 310
24 -19.8005xif_A mol:protein length:500 Prolyl-tRNA synthetase (ProRS)  ali model follow..  15  28.................................................................................................................................................................................................YYDISGCYIMRPWAFHIWEKVQRFFDDEIKKMGVENSYFPMFVSRHKLKEKDHVEGFSPEVAWVTHYPEKIAIRPTSETIMYPAYAKWIRSHRDLPLKLNQWCSVVRWEF----KQPTPFLRTREFLWQEGHTAHATE-EEAWELVLDILELYRRWYEECLAVPVIKGEKSEEKFAGGKKTTTVEAFIPENGRGIQAATSHLLGTNFAKMFEIEFEDEEGHKR--------LVHQTSWGCTTRSLGVMIMTHGDDKGLVIPPRVASV........................ 288
25 -19.1004p3n_A mol:protein length:415 Threonine--tRNA ligase, cytoplasmic  ali model follow..  14  3..........................................................................................................................................................................SSSSGDHRKIGRDQELYFFHE----LSPGSCFFLPKGAYIYNALIEFIRSEYRKRGFQEVVTPNIFNSRLWMTSGHWQHYSENMFSFEVEKELFALKPMNCPGHCLMFDHRPRSWRELPLRLADFGVLHRNELSG---ALTGLTRVRRFQQDDAHIFCA--MEQIEDEIKGCLDFLRTVYSVFGFSFKLNLSTRPELG-------DIEVWDQAEKQLENSLNEFGEKDFQPIRFNLTYVSHDGDDK--KRPVIVH--RAILGSVERMIAILTENYGGK----WPFWLSP......................... 304
26 -18.9003a31_A mol:protein length:471 Probable threonyl-tRNA synthetase 1  ali model follow..  13  18..........................................................................................................................................................................ITVKPDSRVPVFNREFATF------TGAGVPLFSLGGGPIRYALAEVLAKFHARRGYYVVETPIIASTELFKVSGHIEFYRNNMYLFDIEGHEFAVKPMYHILLFLNEVAKHRSKLPLPFKVFEFGRVHRYEPSG---SIYGLLRVRGFTQDDAHIIVPGGRVIDVEEWEGAEEALREAASRINEKYGIDIVELEGEAAFYGPKLDFIMMVEESGVSKEWQMGTIQFDFNPRRFRLYDVVREEFGI--EEVYIIH--RALLGSIERFLGVYLEHRRGR----MPFTLAP......................... 338
27 -18.9004hwt_A mol:protein length:413 Threonine--tRNA ligase, cytoplasmic  ali model follow..  14  2.............................................................................................................................................................................ARDHRKIGRDQELYFFHE----LSPGSCFFLPKGAYIYNALIEFIRSEYRKRGFQEVVTPNIFNSRLWMTSGHWQHYSENMFSFEVEKELFALKPMNCPGHCLMFDHRPRSWRELPLRLADFGVLHRNELSG---ALTGLTRVRRFQQDDAHIFCA--MEQIEDEIKGCLDFLRTVYSVFGFSFKLNLSTRPELG-------DIEVWDQAEKQLENSLNEFGEKDFQPIRFNLTYVSHDGDDK--KRPVIVH--RAILGSVERMIAILTENYGGK----WPFWLSP......................... 300
28 -18.8002j3l_A mol:protein length:572 PROLYL-TRNA SYNTHETASE  ali model follow..  14  32................................................................................................................................................................................................IRQVAAGIYSYLPLANRVLEKLKTIMREEFEKIDAVEMLMPALLPAELWKESGRYETYGPNLYRLKDRNDDYILGPTHEETFTELIRDEINSYKRLPLNLYQIQTKYRDEK----RSRSGLLRGREFIMKDGYSF-HADEASLDQSYRDYEKAYSRIFERCGLEFRAIIGDGGAMGGKDSKEFMAISEIGEDT---EIGHIFKLGTRYSDAMGATVLDENGREKS--------IMGCYGIGVSRLLSAIVEQNADERGINWPTGIAPF........................ 471
29 -18.7004hwo_A mol:protein length:411 Threonine--tRNA ligase  ali model follow..  12  2.............................................................................................................................................................................ARDHRKIGKQLDLYHMQE----EAPGMVFWHNDGWTIFRELEVFVRSKLKEYQYQEVKGPFMMDRVLWEKTGHWDNYKDAMFTTSSENREYCIKPMNCPGHVQIFNQGLKSYRDLPLRMAEFGSCHRNEPSG---SLHGLMRVRGFTQDDAHIFCT--EEQIRDEVNGCIRLVYDMYSTFGFEKIVVKLSTRPEKRIG----SDEMWDRAEADLAVALEENNIPDFSPSRLSASYVGEDNERK---VPVMIH--RAILGSMERFIGILTEEFAGF----FPTWLAP......................... 300
30 -18.4001nj1_A mol:protein length:501 Proline-tRNA Synthetase  ali model follow..  14  28.....................................................................................................................................................................GEKMTEFSEWFHNILEE-AEIIDQRY----PVKGMHVWMPHGFMIRKNTLKI-LRRILDRDHEEVLFPLLVPEDELKEAIHVKGFEDEVYWVSKLQRKLALRPTSETVMYPMFALWVRSHTDLPMRFYQVVNTFRYETKHT---RPLIRVREITTFKEAHTI--ATASEAEEQVERAVEIYKEFFNSLGIPYLITRRPPWDKFPGSEYTVAFDTLMPDGKT--QIGTVHNLGQTFARTFEIKFETPEGDHE--------YVHQTCYGLSDRVIASVIAIHGDESGLCLPPDVAAH........................ 309
31 -18.3005ucm_A mol:protein length:579 Proline--tRNA ligase  ali model follow..  15  34................................................................................................................................................................................................IRRLASGLYTWLPMGLRVLRKVETIVREEMNAAGALEVLMPAVQPAELWQESGRWEQYGPELLRLKDHEREFCVGPTHEEVITDLARNELNSYKQLPINFYQIQTKFRDEI----RPRFGLMRGREFIMKDAYSF-HLSQDSLQQTYDGMYQAYSKIFSRLGLDFRPVQADNGSIGGSGSHEF-----VLANSGEDDIVFSDSS-DYAANQLGTKYSEAMKLSVLSEQGKPVNLIMGCGIGVSRVVAAAIEQNHDERGILWPSALAPF........................ 474
32 -17.9001nyq_A mol:protein length:645 threonyl-tRNA synthetase 1  ali model follow..  13  237..........................................................................................................................................................................ERKERDHRKIGKELELFTNS---QLVGAGLPLWLPNGATIRREIERYIVDKEVSMGYDHVYTPVLANVDLYKTSGHWDHYQEDMFPPLDETESMVLRPMNCPHHMMIYANKPHSYRELPIRIAELGTMHRYEASG---AVSGLQRVRGMTLNDSHIFVR--PDQIKEEFKRVVNMIIDVYKDFGFEDYSFRLSYRDPEDKEKYFDDDDMWNKAENMLKEAADELGLSDFLPERFDLTYIGQDGEHH---RPVVIH--RGVVSTMERFVAFLTEETK-----AFPTWLAP......................... 545
33 -17.7001qf6_A mol:protein length:642 THREONYL-TRNA SYNTHETASE  ali model follow..  13  238..........................................................................................................................................................................EAAKRDHRKIGKQLDLYHMQE----EAPGMVFWHNDGWTIFRELEVFVRSKLKEYQYQEVKGPFMMDRVLWEKTGHWDNYKDAMFTTSSENREYCIKPMNCPGHVQIFNQGLKSYRDLPLRMAEFGSCHRNEPSG---SLHGLMRVRGFTQDDAHIFCT--EEQIRDEVNGCIRLVYDMYSTFGFEKIVVKLSTRPEKRIG----SDEMWDRAEADLAVALEENNIPDFSPSRLSASYVGEDNERK---VPVMIH--RAILGSMERFIGILTEEFAGF----FPTWLAP......................... 539
34 -17.6003ugq_A mol:protein length:460 Threonyl-tRNA synthetase, mitochondrial  ali model follow..  12  2........................................................................................................................................................GSSSSGLVPRGSHKNASSATPATMTSMVSQRQDLFMTDP----LSPGSMFFLPNGAKIFNKLIEFMKLQQFKFGFNEVVTPLIYKKTLWEKSGHWENYADDMFKVETTDEEKEEYGLKPMNCPGIFGKKDRSYNELPLRFSDFSPLHRNEASG---ALSGLTRLRKFHQDDGHIFCT--PSQVKSEIFNSLKLIDIVYNKIFPFVKGGSGAESNYFINFSTR-DLKVWNHAEQVLKEILEESGKPDFQPERFDLKFKDQDNSYK---RPIMIH--RATFGSIERFMALLIDSNEGR----WPFWLNP......................... 339
35 -14.3001b76_A mol:protein length:442 Glycine--tRNA ligase  ali model follow..  16  9.................................................................................................................................................................................VALCKRRGFIFQSSEIYGGLQGVYDYGPLGVELKNNLKQAWWRRNVRDDMEGLDASVLTHRLVLHYSGHEATFADPMVDRGGRGLLAYLRPTAQGIFVNFKNVLDATSRKLGFGIAQIGKAFRNEITPR----NFIFRVREFEQMEIEYFV--RPGEDEYWHRYWVEERLKWWQEMGLSLVPYQQPPESSAHYAKATVDILYRFP---GSLELEGIAQRTDFDLGS-NEHSTQRLAYRDPETGKWFVPYVIEPSAGVDRGVLALLAEAFTRE-LKLKPQLAPI........................ 336
36 -14.2004cs2_A mol:protein length:274 PYRROLYSINE--TRNA LIGASE  ali model follow..  18  48.........................................................................................................................................................................................................IYAEERENYLGKLEREITRFFVDRGFLEIKSPILIPLEYIERMG--DNDTELSKQIFRVDKNFCLRPMLAPNLANYLR-KLDRALPDPIKIFEIGPCYRKESDGKE-------HLEEFTMLNFCQM------GSGCTRENLESIITDFLNHLGIDFKIV............................................................................................................................ 191
37 -13.5004bw9_A mol:protein length:291 PYRROLYSINE--TRNA LIGASE  ali model follow..  16  65.........................................................................................................................................................................................................IYAEERENYLGKLEREITRFFVDRGFLEIKSPILIPLEYIERMG--DNDTELSKQIFRVDKNFCLRPMLAPNLGNYLR-KLDRALPDPIKIFEIGPCYRKESDGKE-------HLEEFTMLNFCQM------GSGCTRENLESIITDFLNHLGIDFKI............................................................................................................................. 207
38 -13.3004q6g_A mol:protein length:267 Pyrrolysine--tRNA ligase  ali model follow..  17  59.....................................................................................................................................................................................................................LEREITRFFVDRGFLEIKSPILIPLEYIERMG---DNDTELSKQIFRVDKNFCLRPMVAPNIFNYARKLDRALPDPIKIFEIGPCYRKESDGKE-------HLEEFTMLNFFQM------GSGCTRENLESIITDFLNHLGIDFKILELSSAVVGPIPLDRFGLERLLKVKHDFKNIKRARSESYYNGISTNL.............................................................................. 267
39 -12.9003qtc_A mol:protein length:290 Pyrrolysyl-tRNA synthetase  ali model follow..  16  62.........................................................................................................................................................................................................IYAEERENYLGKLEREITRFFVDRGFLEIKSPILIPLEYIERMG--DNDTELSKQIFRVDKNFCLRPMLTPNLYNYLRKLDRALPD-PIKIFEIGPCYRKESDGKE-------HLEEFTMLVFWQM------GSGCTRENLESIITDFLNHLGIDFKIV............................................................................................................................ 205
40 -12.5005k1p_A mol:protein length:274 Pyrrolysine--tRNA ligase  ali model follow..  14  48.........................................................................................................................................................................................................IYAEERENYLGKLEREITRFFVDRGFLEIKSPILIPLEYIERMG---DNDTELSKQIFRVDKNFCLRPMLAPNLYNYLRKLDRALPDPIKIFEIGPCYRKESDGKE-------HLEEFTMLAFAQM------GSGCTRENLESIITDFLNHLGIDFKIVGDSCMVYGDTLDVM----------HGDLELSSAVVGPIPLDREWGID-----------------KPWIGAGFGLERLLKVAARSESYYNGIST............................... 266
41 -12.1001ati_A mol:protein length:505 GLYCYL-TRNA SYNTHETASE  ali model follow..  16  125..............................................................................................................................................................................................................LHALVQAMMQAPERAGGAMTAAGVLDPASGEPGDWTPPRYFN-FQDLRGPRGGRGLLAYLRPTAQGIFVNFKNVLDATSRKLGFGIAQIGKAFRNEITPR----NFIFRVREFEQMEIEYFV--RPGEDEYWHRYWVEERLKWWQEMGLSLVPYQQPPESSAHYAKATVDILYRFP---GSLELEGIAQRTDFDLGS-NEHSTQRLAYRDPETGKWFVPYVIEPSAGVDRGVLALLAEAFTRE-LKLKPQLAPI........................ 399
42 -11.9004tqd_A mol:protein length:291 Pyrrolysine--tRNA ligase  ali model follow..  14  65.........................................................................................................................................................................................................IYAEERENYLGKLEREITRFFVDRGFLEIKSPILIPLEYIERMG---DNDTELSKQIFRVDKNFCLRPMLAPNLYNYLRKLDRALPDPIKIFEIGPCYRKESDGKE-------HLEEFTMLSFIQM------GSGCTRENLESIITDFLNHLGIDFKIVGDSCMVYGDTLDVM----------HGDLELSSAVVGPIPLDREWGIDKP-------------------GAGFGLERLLKVAARSESYYNGIST............................... 283
43 -11.5002e3c_A mol:protein length:291 Pyrrolysyl-tRNA synthetase  ali model follow..  14  65.........................................................................................................................................................................................................IYAEERENYLGKLEREITRFFVDRGFLEIKSPILIPLEYIERMG---DNDTELSKQIFRVDKNFCLRPMLAPNLYNYLRKLDRALPDPIKIFEIGPCYRKESDGKE-------HLEEFTMLNFCQM------GSGCTRENLESIITDFLNHLGIDFKIVGDSCMVYGDT----------LDVMHGDLELSSAVVGPIPLDREWGID-----------------KPWIGAGFGLERLLKVAARSGSYYNGIST............................... 283
44 -10.6002zni_A mol:protein length:308 Pyrrolysyl-tRNA synthetase  ali model follow..  12  88...................................................................................................................................................................................................................LELEEKLAKALHQQGFVQVVTPTIITKSALAKMT---GEDHPLFSQVFWLDGKKCLRPMLAPNLYTLWRELERLWDKPIRIFEIGTCYRKESQGAQ-------HLNEFTMLNLTELGTPLEERH----QRLEDMARWVLEAAGI---------REFELVTESSVVYGDTVDVMKGDLELASGAMGPHFLDEKWEI----------------------GLGFGLERLLMI-REGTQHVQSMARSLSYLDG........................ 296
45 -9.5301nnh_A mol:protein length:294 asparaginyl-tRNA synthetase-related peptide  ali model follow..  14  12............................................................................................................................................................................................................SPTLDIQTKILEYMTDFFVKEGFKWLLPV-IISPITDPLWPDPAGEGMEPAEVEIYGVKMRLTHSMI-----LHKQLAIAMG----KIFVLSPNIRLESRQKDDGR----HAYEFTQLDF--------EVERAKMEDIMRLIERLVYGL-FEYEVLEEFGSDEKASQEMEEPFWI-IPRE-GYGEVASGG------EREWEYEKIVAKIRKAGLNEDSFRPYLEGAGIGVERLVRFIVGAKHIAEVQPFPR............................. 286
46 -9.5003p8t_A mol:protein length:294 AsnS-like asparaginyl-tRNA synthetase related protein  ali model follow..  12  13.............................................................................................................................................................................................................KAIDIQTKILDYMTKFFTDRGFKWLLPI-MLSPITDPLWPDPAGEGIRPAEVDVYGVRMRLTHSMI-----LHKQLAIAMG----KIFVLSPNIRLESRRKDDGR----HSYEFTQLDF--------EIEGAKMKDVMRLIEELIYGL----KAEEWTGREF--PRARHFKVYDYKDILEEFGEVSSGG------EREWEYEKIVAKIRAAGLKEDSFRPYLEGAGIGVERLVRFIVGAKHIAEVQPFPR............................. 286
47 -9.4903g1z_A mol:protein length:326 Putative lysyl-tRNA synthetase  ali model follow..  11  15.............................................................................................................................................................................................................PNLLKRAAIMAEIRRFFADRGVLEVETP-CMSQATVTDIHLFPFETRFVGPGHSQGINLYLMTSPEYHMKRLLAAGC--------PVFQLCRSFRNE---------EMGRHHEFTMLEWY--------RPHYDMYRLMNEVDDLLQQV--PTFIYHFPASQASLAQISTEDFEVYYKGANGFHELTDARE----QQQRFDNRKRAARGLPQQPIDQNLLDALAGVALGVDRLVMLALGAESLADVIAFT.............................. 322
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Awobuluyi M, Yang J, Ye Y, Chatterton JE, Godzik A, Lipton SA, Zhang D. Subunit-specific roles of glycine-binding domains in activation of NR1/NR3N-methyl-D-aspartate receptors. Mol Pharmacol. 2007 Jan;71(1):112-22. Epub 2006 Oct 17.