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Query: 3w3s_A mol:protein length:527 Type-2 serine--tRNA ligase, from PDB1018

Results of FFAS03 search in PDB1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MELKFSAEVELTLSREVDPAEIEPTVEEFVKEANEDLLQRGVPTGKEGAKIESYYVLYDTIYMEITGTRYLRPHEAAMRVRKRLAERLGRKHRVGVRDLKIPRYEVVLRFDREVTYDYVGYVPVADDVVVEDGTVRLTFQDVDEEMLRRHVIDRVIRLVAWAVEERSELVERVTKVEPGTVVDESGPRRIRFRGDVTEEARRRGWVKEFPGRGQWIYTPPMAALFEVLRDFLLERVTRKLGFEPALFPKLIPLETMFRMRYLHGLPDGMYYVCPPKRDPELFDDFKRELYVWGELNERTLGSLKEKLRDPGYVLAPAQCEPFYELLRDEVVDPERLPIKLYDCSGWTYRWEGGAAKGLERVNEFQRIEHVWIAEPEEAYRIRRELLEATKRVAEELELEWKVVVSDDPFYLEGRLLEDRDIELPDVPSYEFEVYLPFKGERSSEEAWISVGSFNVHGEHFVDGFNVKEKSGRTLFTGCAGLGVTRWVVGLLAQHGFYPYEWPEPILERIDEKFGGLPEVPKTLTWPELast
1 -171.0003w3s_A mol:protein length:527 Type-2 serine--tRNA ligase  ali model  100  1MELKFSAEVELTLSREVDPAEIEPTVEEFVKEANEDLLQRGVPTGKEGAKIESYYVLYDTIYMEITGTRYLRPHEAAMRVRKRLAERLGRKHRVGVRDLKIPRYEVVLRFDREVTYDYVGYVPVADDVVVEDGTVRLTFQDVDEEMLRRHVIDRVIRLVAWAVEERSELVERVTKVEPGTVVDESGPRRIRFRGDVTEEARRRGWVKEFPGRGQWIYTPPMAALFEVLRDFLLERVTRKLGFEPALFPKLIPLETMFRMRYLHGLPDGMYYVCPPKRDPELFDDFKRELYVWGELNERTLGSLKEKLRDPGYVLAPAQCEPFYELLRDEVVDPERLPIKLYDCSGWTYRWEGGAAKGLERVNEFQRIEHVWIAEPEEAYRIRRELLEATKRVAEELELEWKVVVSDDPFYLEGRLLEDRDIELPDVPSYEFEVYLPFKGERSSEEAWISVGSFNVHGEHFVDGFNVKEKSGRTLFTGCAGLGVTRWVVGLLAQHGFYPYEWPEPILERIDEKFGGLPEVPKTLTWPE 527
2 -119.0002cim_A mol:protein length:522 SERYL-TRNA SYNTHETASE  ali model follow..  30  15MKLQFNLKAYFKTSADPTPAK--DAIAALFEEANSTLLTRGAPE-GQGAKVTEWKLGEDRIELTLQSGRYVRVHDAIFRLRKQLAEALGKKYKIGIRGIEVESFIIKVPADHELR---MLKVPYIKSMENIEGGIQLELE-VGEAEMKNRVPDRILTLLEEKIEA----AQYGAKAEHWNLLWQREPMEHPFKEDPTQAMMKEGWLKRGSSRGQWIHGPQSARIFRTFEKIVLEELLEPLGYREMIFPKLVTWEVWMKSGHAKGVPEIYYVCPPQTRDPDYWEEVADYYKVTHEVPTKLIK---EKIAEPIGGMCYAQCPPFWMYVAGETLPNEEIPVKVFDRSGTSHRYESGGIHGIERVDEFHRIEIVWIGTKEEVLKCAEELHDRYMHIFNDILDIEWRKARVTPWFMAQEG-LLGLAEENTVGTTDYEACLPYRG---PDGEWLEFQNVSINGDKYPKGFNVKLQSGDELWSGCSGVGLERWAAVFLAQKGLDPANWPEEFRNRVGEMPKGIRFL........ 516
3 -76.7004h2w_A mol:protein length:346 Amino acid--[acyl-carrier-protein] ligase 1  ali model follow..  20  1..........................................................................................................................................................MGSSSSGLVPRGSHMNIAV----------PNSPDTAPQIADPLDHLADKLFH-SMGSDGVYARTALYESIVERLAALITS--HREAGTEALRFPPVMSRAQLEKSGYLKSFPNLLGCVCGLHGTEREINAAVSRFD--------AGGDWTTSLSPADLVLSPAACYPVYPIAASRGPLPKG---LRFDVAADCFRREPS--KHLDRLQSFRMREYVCIGTPDDVSDFRERWMVRAQAIARDLGLTFRVDYASDPFFGRAGKM-LANNQRDQQLKFELLIPLRSEEQP------TACMSFNYHREHFGTTWGIQDANGEPAHTGCVAFGMDRLAVAMFHTHGTDLSAWPAKVRDILG................. 325
4 -75.4003mey_A mol:protein length:346 Bll0957 protein  ali model follow..  20  1..........................................................................................................................................................MGSSSSGLVPRGSHMNIAVLP---------NSPDTAPQIADPLDHLADKLFH-SMGSDGVYARTALYESIVERLAALITS--HREAGTEALRFPPVMSRAQLEKSGYLKSFPNLLGCVCGLHGTEREINAAVSRFD--------AGGDWTTSLSPADLVLSPAACYPVYPIAASRGPLPKG---LRFDVAADCFRREPS--KHLDRLQSFRMREYVCIGTPDDVSDFRERWMVRAQAIARDLGLTFRVDYASDPFFGRVGQM-KAVSQKQQQLKFELLIPLRSEEQP------TACMSFNYHREHFGTTWGIQDANGEPAHTGCVAFGMDRLAVAMFHTHGTDLSAWPAKVRDILG................. 325
5 -63.3002dq3_A mol:protein length:425 Seryl-tRNA synthetase  ali model follow..  18  1........................MIDINLIREKPDYVKERLATRDKELV----SLVDKVLELDKRRREIIKRLEALRSERNKLSKEIGKLKREG--------------------KDTTEIQNRVKELKEEIDRLEEELRKVEEE--LKNTLLWIPNLPHPSVPVGEDEKDNVEVRRWGEPRKFDFEPKPHWEIGERLGILDFKRGAKLSGSRFTVIAGWGARLERALINFMLDLHTKK-GYKEICPPHLVKPEILIGTGQLPKFEEDLYKC-----------------------------------ERDNLYLIPTAEVPLTNLYREEILKEENLPIY-LTAYTPCYRREAGAIRGIIRQHQFDKVELVKIVHPDTSYDELEKLVKDAEEVLQLLGLPYRVV-----------ELCTGDLGFSAAKTYDIEVWFPSQNKYREISSCSNCEDFQARRMNTRFKDSKTGKNRFVHTLNGSGLAVGRTLAAILENYQQEDGS--VVVPEVLRDYVGTDVIRPE...... 425
6 -60.6002dq0_A mol:protein length:455 Seryl-tRNA synthetase  ali model follow..  15  1........................MLDIKLIRENPELVKNDLIKRGELEKVK---WVDEILKLDTEWRTKLKEINRLRHERNKIAVEIGKRRKKG--------------------EPVDELLAKSREIVKRIGELENEVEELKKK--IDYYLWRLPNITHPSVPVGKDENDNVPIRFWGKA-ILEWKPKLHVDLLEILGGADFARAAKVSGSRFYYLLNEIVILDLALIRFALDRLIEK-GFTPVIPPYMVRRFVEEGSTSFEDFEDVIYKV-----------------------------------EDEDLYLIPTAEHPLAGMHANEILDGKDLPLL-YVGVSPCFRKEAGTTKGIFRVHQFHKVEQFVYSRPEESWEWHEKIIRNAEELFQELEIPYRVV-----------NICTGDLGYVAAKKYDIEAWMPGQGKFREVVSASNCTDWQARRLNIRFRDRTDEKPRYVHTLNSTAIATSRAIVAILENHQEEDGT--VRIPKVLWKYTGFKEIVPVEKKERC 452
7 -60.1003vbb_A mol:protein length:522 Seryl-tRNA synthetase, cytoplasmic  ali model follow..  13  1.....................MVLDLDLFRVDGDPALIRETQEKRFKDPGL-----VDQLVKADSEWRRCRFRADNLNKLKNLCSKTIGEKMKKKEPVGDDESVPENVLSFDDLTLKVSQIKKVRLLIDEAILKCDAERIKLEAE--RFENLREIGNLLHPSVPISNDEDVDN-KVERIWGDCTVRKKYSHVDLVVMVDGFEGEKGAVVAGSRGYFLKGVLVFLEQALIQYALRTLGSR-GYIPIYTPFFMRKEVMQEVAQLSQFDEELYKVIGKGSEKS------------------------DDNSYDEKYLIATSEQPIAALHRDEWLRPEDLPIK-YAGLSTCFRQEVGSTRGIFRVHQFEKIEQFVYSSPNKSWEMFEEMITTAEEFYQSLGIPYHIV-----------NIVSGSLNHAASKKLDLEAWFPGSGAFRELVSCSNCTDYQARRLRYGQTKKMMDKVEFVHMLNATMCATTRTICAILENYQTEKG---ITVPEKLKEFMPPQELIPFVKPAPI 476
8 -59.4003lsq_A mol:protein length:484 Seryl-tRNA synthetase  ali model follow..  13  1................GPGSMMVLDIQLFRDETGANIIRESQRRRFADPDI-----VDAIIEADKKWRRTQFLTEASKKLINICSKAVGAKKKAKEADGDTSEIPPQVKEAYENGTCVLQLKQLSKDLSDQVAGLAKEAQQLEEE--RDKLMLNVGNILHESVPIAQDEETGNTVVRTFGNTTKRAKLNHVSIMERLGMMDTSKAVTSMAGGRSYVLKGGLVQLQVALVSYSLDFLVKR-GYTPFYPPFFLNRDVMGEVAQLSQFDEELYQVSG---------------------------------DGDKKYLIATSEMPIAAYHRGRWFTELKEPLK-YAGMSTCFRKEAGATLGIFRVHQFDKIEQFVVCRQEESWRHLEDMITTSEEFNKSLGLPYRVV-----------NICSGALNNAAAKKYDLEAWFPASGAFRELVSCSNCTDYQSQSVNCRYG-AAQNVKEYCHMLNGTLCAITRTMCCICENYQTEEG---VVIPDVLRPYMMGIEMIRFENNAQA 475
9 -59.4001ser_A mol:protein length:421 PROTEIN (SERYL-TRNA SYNTHETASE (E.C.6.1.1.11))  ali model follow..  15  1........................MVDLKRLRQEPEVFHRAIREKGVALDL------EALLALDREVQELKKRLQEVQTERNQVAKRVPKAPP----------------------EEKEALIARGKALGEEAKRLEEALREKEAR--LEALLLQVPLPPWPGAPVGGEEANREIKRVGGP--PEFSFPPLDHVALMEKNGWWEPRISQVSGSRSYALKGDLALYELALLRFAMDFMARR-GFLPMTLPSYAREKAFLGTGHFPAYRDQVWAI-----------------------------------AETDLYLTGTAEVVLNALHSGEILPYEALPLR-YAGYAPAFRSEAGSVRGLMRVHQFHKVEQYVLTEAEASDRAFQELLENAEEILRLLELPYRLV-----------EVATGDMGPGKWRQVDIEVYLPSEGRYRETHSCSALLDWQARRANLRYR-DPEGRVRYAYTLNNTALATPRILAMLLENHQLQDGR--VRVPQALIPYMGKEVLEPC...... 420
10 -58.1003qne_A mol:protein length:485 Seryl-tRNA synthetase, cytoplasmic  ali model follow..  13  1......................MLDINAFLVEGDPEIIKASQKKRGDSVEL-----VDEIIAEYKEWVKLRFDLDEHNKKLNSVQKEIGKRFKAK--------------------EDAKDLIAEKEKLSNEKKEIIEKEAEADKNL--RSKINQVGNIVHESVVDSQDEENNELVRTWTPAATGAPAKLSHHEVLLRLDGYDPERGVRIVGHRGYFLRNYGVFLNQALINYGLSFLSSK-GYVPLQAPVMMNKEVMAKTAQLSQFDEELYKVID---------------------------------GEDEKYLIATSEQPISAYHAGEWFESEQLPVR-YAGYSSCFRREAGSAWGIFRVHAFEKIEQFVLTEPEKSWEEFDRMIGCSEEFYQSLGLPYRVV-----------GIVSGELNNAAAKKYDLEAWFPFQQEYKELVSCSNCTDYQSRNLEIRCGIQNQQEKKYVHCLNSTLSATERTICCILENYQKEDG---LVIPEVLRKYIPGEPEFIPYIK... 446
11 -57.0001wle_A mol:protein length:501 Seryl-tRNA synthetase  ali model follow..  15  18......RNLLYEHAREGYSALPLLDMESLCA--YPEDAARALDLRKGELRSKD---LPGIISTWQELRQLREQIRSLEEEKEAVTEAVRALVVNQDNS------------QVQQDPQYQSLRARGREIRKQLTLLYPKEAQLEEQF--YLRALRLPNQTHPDVPVGDE-SQARVLHVVGDKPAFSFQPRGHLEIAEKLDIIRQKRLSHVSGHRSYYLRGAGALLQHGLVNFTLNKLIHR-GFTPMTVPDLLRGVVFEGCGMTPNAKPSQIYNI-------------------------------DPSRFEDLNLAGTAEVGLAGYFMDHSVAFRDLPIR-MVCSSTCYRAETDTPWGLYRVHHFTKVEMFGVTGPEQSSELLEEFLSLQMEILTELGLHFRVL-----------DMPTQELGLPAYRKFDIEAWMPGRGRFGEVTSASNCTDFQSRRLHIMFQ-TEAGELQFAHTVNATGCAVPRLLIALLESYQQKDGS--VLVPPALQPYLGTDRITTPT..... 471
12 -55.6006blj_A mol:protein length:485 Serine-tRNA ligase  ali model follow..  11  2.....................AMLDINLFREYGNPEIIRESQRRRFADVTL-----VDKVIELDEVWRATIGKLNHIKSFTGIISKEVGNRMKNKVPLYALFTKEALEQGSLAKLNTNQLKKLSTYITEVHIKNSEEEVKQKEKE--RDDVLLQIGNIVHETVVVSDNEDNNGIVRMVGNPRETGYKCLKHIDIMRKLGGLATEEGTQVGGGRGYFLLGDLVRMNLALQNYAIDFLAKK-GYMPIYTPFFMTKEQMKKVAQLSQFDEELYTVTG---------------------------------EGEDKYLIATSEQPIAAFHLEKRFDESELPIK-YCGMSTCFRKEVGATLGIFRVHQFEKIEQFVVTSPKDSWEMFDEMIGNSEAFYQSLGIPYRVV-----------NIVSGALNNAAAKKFDLEAWFPGGNEYRELVSCSNCTDYQTRRLEYGKSKKQGSEVEFCHMLNSTLTATSRTLCCIVENYQTPEG---VNVPEVLQPYMGGTKFIKFK..... 478
13 -53.0003err_A mol:protein length:536 fusion protein of microtubule binding domain from mouse cytoplasmic dynein and seryl-tRNA synthetase from Thermus thermophilus  ali model follow..  15  110..........................QIRSIIMRENFIPTIVNFSAEEISD------AIREKMKKNYMSNPSYNYEIVNRASLAAGPMVKWAIAQ--------------------LNYADMLKRVEPLRNELQKLEDDAKDNQQKL--EALLLQVPLPPWPGAPVGGEEANREIKRV-GGPPEFSFPPLDHVALMEKNGWWEPR-ISQVSGSRSYALKGDLALYELALLRFAMDFMARR-GFLPMTLPSYAREKAFLGTGHFPAYRDQVWAI-----------------------------------AETDLYLTGTAEVVLNALHSGEILPYEALPLR-YAGYAPAFRSEAGSVRGLMRVHQFHKVEQYVLTEASASDRAFQELLENAEEILRLLELPYRLV-----------EVATGDMGPGKWRQVDIEVYLPSEGRYRETHSCSALLDWQARRANLRYR-DPEGRVRYAYTLNNTALATPRILAMLLENHQLQDGR--VRVPQALIPYMGKEVLEPG...... 529
14 -24.5004ncx_A mol:protein length:506 Proline--tRNA ligase  ali model follow..  16  3..................................................................................................................................................................................SNILGITSKKIENFSDWYTQVIVKSELIEYYDISGCYILRPAAYYIWECVQAFFNKEI-KKLNVENSYFPLFVTKNKLKEKNHIEGFSPEVAWVTKYGDSNL----------------------------PEEIAIRPTSETIMYSVFPKWIRSYRDLPLKLNQW-NTVVRWEFKQPTPFIRTREFLWQEHTAHKNEEEAVKLVFDILDLYRRWYEEYLAVPIIKGIK----------SEGEKFGGANFTSTAEAFISENGRAIQAATSHYLG--TNFAKMFKIEFEDENEVKQYVHQTSWGCT-TRSIGIMIMTHGDDKGVLPPNV...................... 289
15 -24.4002i4l_A mol:protein length:458 Proline-tRNA ligase  ali model follow..  13  2..................................................................................................................................................................GSSSSGLVPRGSHMRLSRFFLPILKENPKEAEIVSHRLMLRAGMLRQEAAGIYAWLPLGHRVLKKIEQIVREEQ-NRAGAIELLMPTLQLADLWRESGRYDAYGPEMLRIADRHKR--------------------------------ELLYGPTNEEMITEIFRAYIKSYKSLPLNLYHI-QWKFRDEQRPRFGVMRGREFLMKDAYSFDVDEAGRKSYNKMFVAYLRTFARMGLKAIPMRAEDGDLTPIIKQWTSVYAATEDVHEPARYESEVPEANRLNTRGIEVGQIFYFGTKYSDSMKAPDGTDAPIHGGSYGVGVSRLLGAIIEACHDDNGIWPEAV...................... 357
16 -24.4005xip_A mol:protein length:498 Prolyl-tRNA synthetase, putative  ali model follow..  17  6........................................................................................................................................................................................TAKKSTNFADWYTQVIVRGELVEYYDISGCYIIRPWAYRIWEAVQKFFDDGI-KRLGVENCYFPMFVSQAKLKEKDHVEGFKPEVAWVTHYGDSE-----------------------------PEKVAIRPTSETIMYPAYAKWIRSHRDLPLKLNQW-NNVVRWEFKQPTPFLRTREFLWQEHTAHATEEEAYTLVLEILELYRQWYEDYLAVPVIKGEKSENEKFAGGKKTTTIEGIIP----------------DTGRGIQAATSHLLGQNFSRMFSIEKGAKQLVHQTSWGCTT-RSLGVMIMTHGDDKGVLPPRV...................... 286
17 -24.2004k86_A mol:protein length:535 Proline--tRNA ligase  ali model follow..  18  1..................................................................................................................................................MGSSSSGLVPRGSHMASGAGEGQGPKKQTRLGLEAKKEENLADWYSQV-----ITKSEMIEYHDISGCYILRPWAYAIWEAIKDFFDAEI-KKLGVENCYFPMFVSQSALEKEKTHVADFAPEVAWVTRSGKTEL---------------------------AEPIAIRPTSETVMYPAYAKWVQSHRDLPIKLNQW-CNVVRWEFKHPQPFLRTREFLWQEHSAFATMEEAAEEVLQILDLYAQVYEELLAIPVVKGRK----------TEKEKFAGGDYTTTIEAFISASGRAIQGGTSHHLGQ------NFSKMFEIPKIPGEKQFAYQNSWGLTRTIGVMTMVHGDNMGVLPPRV...................... 316
18 -24.2004hvc_A mol:protein length:519 Bifunctional glutamate/proline--tRNA ligase  ali model follow..  19  18........................................................................................................................................................................................EAKKEENLADWYSQVITKSEMIEYHDISGCYILRPWAYAIWEAIKDFFDAEI-KKLGVENCYFPMFVSQSALEKEKHVADFAPEVAWVTRSGKTEL----------------------------AEPIAIRPTSETVMYPAYAKWVQSHRDLPIKLNQW-CNVVRWEFKHPQPFLRTREFLWQEHSAFATMEEAAEEVLQILDLYAQVYEELLAIPVVKGRK----------TEKEKFAGGDYTTTIEAFIS------ASGRAIQGGTSHHLGQNFSKMFEIPKIPGEKQFAYQNSWGLTRTIGVMTMVHGDNMGVLPPRV...................... 300
19 -23.8005xif_A mol:protein length:500 Prolyl-tRNA synthetase (ProRS)  ali model follow..  18  5........................................................................................................................................................................................TAKKDENFSEWYTQAIVRSEMIEYYDISGCYIMRPWAFHIWEKVQRFFDDEI-KKMGVENSYFPMFVSRHKLKEKDHVEGFSPEVAWVTHYGDSPL----------------------------PEKIAIRPTSETIMYPAYAKWIRSHRDLPLKLNQW-CSVVRWEFKQPTPFLRTREFLWQEHTAHATEEEAWELVLDILELYRRWYEECLAVPVIKGEKSEGEKFAGGKKTTTVEAFIP----------------ENGRGIQAATSHLLGTNFAKMFEIEEGHKRLVHQTSWGCTT-RSLGVMIMTHGDDKGVIPPRV...................... 285
20 -22.9001nj8_A mol:protein length:459 Proline-tRNA Synthetase  ali model follow..  19  1.........................................................................................................................................................................................GSHMLEFSEWYSDILEKAEIYVRYPIKGCGVYLPYGFKIRRYTFEIIRNLL-DESGHDEALFPMLIPEDLLAKEAHIKGFEDEVYWVTHGGKTQL----------------------------DVKLALRPTSETPIYYMMKLWVKVHTDLPIKIYQI-VNTFRYETKHTRPLIRLREIMTFKHTAHSTKEEAENQVKEAISIYKKFFDTLGIPYLISKRP-----------EWDKFPGAEYTMAFDTIFP-------DGRTMQIATVHNLGQNFSKTFEIPTGDKDYAYQTCYGISD-RVIASIIAIHGDEKGILPPIV...................... 280
21 -22.8005f9y_A mol:protein length:511 Aminoacyl-tRNA synthetase  ali model follow..  14  1............................................................................................................................................................................MASKENESLLGITADKITSFADWYSQVIVKSEMIEYYDISGCYILRPWSYFIWETIQSVFDQKI-KQHDVQNAYFPIFVTQKKLTEKDHVEGFSPEVAWVTKSGKSDL----------------------------AEPIAIRPTSETIMYPYFAKWIRSHRDLPLKINQW-TSIVRWEFKHPTPFIRTREFLWQEHTAHSTRKEALEMVDIILNEYASIYEDLLATPVVKGTK----------SENEKFPGGDITKSIEGFIPEIGRAVQAATSHLLG--QNFSKMFGVEFEDEKGNKEYAHQTSWGLT-TRAIGVMIMTHGDNKGVLPPKV...................... 293
22 -22.5005xil_A mol:protein length:512 Putative prolyl-tRNA synthetase  ali model follow..  17  1...................................................................................................................................................................................GAMGIAAKREENFSAWYIDVITKAEMIEYYDVSGCYIIRPWAYYVWKCVQRFLGGKI-EKLGVEDCYFPMFVSRSCLERKDHIEGFAPEVAWVTRAGDTEL----------------------------EQPVAVRPTSETVMYPYYAKWIRSHRDLPVRLNMW-NNVIRWEFSHPTPFIRTREFLWQE-CAWAKAEECAKEVLEILECYASVYEQLLA--------VPVVRGRKTEKEKFAGGDYTTTVETFI--------EAVGRGCQGATSHNLGQNFGKMFDIPENNEQTLIPWQNSWGLTRVIGVMIMVHGDNRGVMPPRVAST................... 291
23 -22.0003ial_A mol:protein length:518 Prolyl-tRNA synthetase  ali model follow..  17  35...............................................................................................................................................................................................................RYPVKGCVVFRPYGFFMENAIMRLCEEEY-AKVGISQILFPTVIPESFLKESDHIKGFEAECFWVEKGGLQPL----------------------------EERLALRPTSETAIYSMFSKWVRSYKDLPLKIHQT-CTIFRHETKNTKPLIRVREIHWNEACCHATAEDAVSQLSDYWKVIDTIFSDELCFKGQKLRR-----------------VCWDRFPGADYSEVSDVVMPCGRVLQTAGIHNLGQRFSSTFDILNKANESVHPYLTCAGITRVLACALSIHGDSGGVLPPLI...................... 291
24 -21.9002j3l_A mol:protein length:572 PROLYL-TRNA SYNTHETASE  ali model follow..  18  1...............................................................................................................................................................................MKQSKMLIPTLREVPNDAEVLSHQILLRAGYIRQVAAGIYSYLPLANRVLEKLKTIMREEF-EKIDAVEMLMPALLPAELWKESGRYETYGPNLYRLKD---------------------------------NDRDYILGPTHEETFTELIRDEINSYKRLPLNLYQIQTK-YRDEKRSRSGLLRGREFIMKDGYSFADEASLDQSYRDYEKAYSRIFERCGLEFRAIIGDG--YAANLEMATSLYTPKKSHETQLDL-SPDGNGVLAFTKGIEIGHIFKLGTRYSDAMGAENGREKSVIMGCYGIGVSRLLSAIVEQNADERG-WPTGI...................... 468
25 -20.9001h4q_A mol:protein length:477 PROLYL-TRNA SYNTHETASE  ali model follow..  18  22.......................................................................................................................................................................................................IQKAELADYGPVRGTIVVRPYGYAIWENIQQVLDRMF-KETGHQNAYFPLFIPMSFLKEAEHVEGFSPELAVVTHAGGEEL----------------------------EEPLAVRPTSETVIGYMWSKWIRSWRDLPQLLNQW-GNVVRWEMR-TRPFLRTSEFLWQE-TAHATREEAEEEVRRMLSIYARLAREYAAIPVIEGLK-----------------TEKEKFAGAVYTTTIEALMKDGKALQAGTSHYLGENFARAFDIKDRDLQVKYVHTTSWGLWRFIGAIIMTHGDDRGVLPPRLAPI................... 288
26 -20.1001b76_A mol:protein length:442 Glycine--tRNA ligase  ali model follow..  13  27.................................................................................................................................................................................................................GLQGVYDYGPLGVELKNNLKQAWWRRVYERDDMEGLDASVLTHRLVLHYSGHEATFADPMVDNAKARYWTPPRYFNMMFQDLRGPRGG----------RGLLAYLRPETAQGIFVNFKNVLATSRKLGFGIAQI-GKAFRNEITPRNFIFRVREFEQMEIEYFVRPGEDEYWHRYWVEERLKWWQEMGLSRENLVPYQ--------QPPESSAHYAKATVDILYRFPHGSLELEGIAQRTDFDLGSHTKDQEALRDPETGKWFVPYVIEPSAGVDRGVLALLEELPNGEERIVLKLKPQLAPIKVAVIPLVKNRP... 348
27 -20.0001nj1_A mol:protein length:501 Proline-tRNA Synthetase  ali model follow..  16  29..........................................................................................................................................................................................EKMTEFSEWFHNILEEAEIIDRYPVKGMHVWMPHGFMIRKNTLKILRRIL--DRDHEEVLFPLLVPEDELKEAIHVKGFEDEVYWVTHGGLSKL----------------------------QRKLALRPTSETVMYPMFALWVRSHTDLPMRFYQV-VNTFRYETKHTRPIRVREITTFKE-TIHATASEAEEQVERAVEIYKEFFNSLGIPYLITRRP-----------PWDKFPGSEYTVAFDTLMPDGKT-------LQIGTVHNLGQTFARTFEIKTPEGDHEYVHQTCYGLDRVIASVIAIHGDESGCLPPDV...................... 306
28 -19.1005ucm_A mol:protein length:579 Proline--tRNA ligase  ali model follow..  15  3...............................................................................................................................................................................MRTSQYLLSTLKETPADAVVISHQLLLRAGMIRRLASGLYTWLPMGLRVLRKVETIVREEM-NAAGALEVLMPAVQPAELWQESGRWEQYGPELLRLKD---------------------------------HEREFCVGPTHEEVITDLARNELNSYKQLPINFYQIQTK-FRDEIRPRFGLMRGREFIMKDAYSFLSQDSLQQTYDGMYQAYSKIFSRLGLDFRPVQADDDIVFSDSSDYAANIEKAEAVPRESAR-SPDGKGTLVIKRGIEVGHIFQLGTKYSEAMKLEQGKPVNLIMGCYGIGVSRVVAAAIEQNHDERGLWPSAL...................... 471
29 -18.8004p3n_A mol:protein length:415 Threonine--tRNA ligase, cytoplasmic  ali model follow..  15  2.......................................................................................................................................................................................GSSSSGDHRKIGRDQELYFFHEL----SPGSCFFLPKGAYIYNALIEFIRSEY-RKRGFQEVVTPNIFNSRLWMTSGHWQHYSENMFSF---------------------------------EVEKELFALKPMNCPGHCLMFDHRPRSWRELPLRLADF-GVLHRNESGALTGLTRVRRFQQDDAHIFCAMEQIEDEIKGCLDFLRTVYSVFGFSFKLNLSTRPFLGDIEVWDQAEKQLENSLKIDIQIKDAIGRYHQCATIQLDFQLPIRFNLTYVSHDGDDKKRPVIVHRAILG-SVERMIAILTENYGGKWPFWLSPRQVMV.................. 309
30 -18.6004hwt_A mol:protein length:413 Threonine--tRNA ligase, cytoplasmic  ali model follow..  16  21..................................................................................................................................................................................................................SPGSCFFLPKGAYIYNALIEFIRSEY-RKRGFQEVVTPNIFNSRLWMTSGHWQHYSENMFSF---------------------------------EVEKELFALKPMNCPGHCLMFDHRPRSWRELPLRLADF-GVLHRNESGALTGLTRVRRFQQDDAHIFCAMEQIEDEIKGCLDFLRTVYSVFGFSFKLNLSTRPFLGDIEVWDQAEKQLENSLKIDIQIKDAIGRYHQCATIQLDFQLPIRFNLTYVSHDGDDKKRPVIVHRAILG-SVERMIAILTENYGGKWPFWLSPRQVMV.................. 305
31 -17.5003ugq_A mol:protein length:460 Threonyl-tRNA synthetase, mitochondrial  ali model follow..  13  24.......................................................................................................................................................................................SATPATMTSMVSQRQDLFMTDPL----SPGSMFFLPNGAKIFNKLIEFMKLQQKFKFGFNEVVTPLIYKKTLWEKSGHWENYADDMFKVETTDEEKE------------------------------EYGLKPMNCPGHCLIFGKKDRSYNELPLRFSDF-SPLHRNESGALSGLTRLRKFHQDDGHIFCTPSQVKSEIFNSLKLIDIVYNKIFPFINFSTRPDHFIGDLKVWNHAEQVLKEILEYGPKLDIMVTDHLRKTHQVATIQDFQLPERFDLKFKDQDNSYKRPIMIHRATFGIERFMALLIDSNEGRWPFWLNPYQAVIIPVNTKNVQQLDMCT... 359
32 -17.0003a31_A mol:protein length:471 Probable threonyl-tRNA synthetase 1  ali model follow..  13  33.............................................................................................................................................................................................................FATFTGAGVPLFSLGGGPIRYALAEVLAKFH-ARRGYYVVETPIIASTELFKVSGHIEFYRNNMYLF---------------------------------DIEGHEFAVKPMNC--LFLNEVAKHRSKLPLPFKVFEF-GRVHRYESGSIYGLLRVRGFTQDDAHIIVPGGRVIDVVYDVFEEMKLVLERLFIDIVELEGEAAFYGPKLDFIMMVEESGVSKEWQFDFNLPRR-YDVVREEFGIEEVYIIHRALLG--------------------SIERFLGVYLEHRRGRMPFTLAPIQFAVIAVKTGGEVDREIEDLAS 361
33 -17.0005k1p_A mol:protein length:274 Pyrrolysine--tRNA ligase  ali model follow..  19  58.............................................................................................................................................................................................................................GKLEREITRFFVD-----RGFLEIKSPILIPLEYIERMG-------------------DNDTELSKQIFRVDK----------------NFCLRPMLAPNLYNYLRKLDRALPD-PIKIFEI-GPCYRKESDGKE---HLEEFTMLAFAQMGSGCTR----ENLESIITDFLNHLGIDFKIVGDS---------------------------CMVYGDTLDVMHGDLELSSAVVGPIPLDREWGIDKP--------GAGFGLERLL---KVKHDFKN------IKRAARSES.............. 259
34 -16.7004hwo_A mol:protein length:411 Threonine--tRNA ligase  ali model follow..  12  21..................................................................................................................................................................................................................APGMVFWHNDGWTIFRELEVFVRSKL-KEYQYQEVKGPFMMDRVLWEKTGHWDNYKDAMFTT---------------------------------SSENREYCIKPMNCPGHVQIFNQGLKSYRDLPLRMAEF-GSCHRNESGSLHGLMRVRGFTQDDAHIFCTEEQIRDEVNGCIRLVYDMYSTFGFVVKLSTRPEKRIGSDEMWDRAEADLAVALEYGPKIEFTLYDCLDRAWQCGTVQDFSLPSRLSASYVGEDNERKVPVMIHRAILGMERFIGILTEEFAGFFPTWLAPVQVVI.................. 305
35 -16.5001qf6_A mol:protein length:642 THREONYL-TRNA SYNTHETASE  ali model follow..  12  45..........VDACDLIENDAQLSIITEIIRHSCAHLLGHAIKQLWPHTKMAIGPVIDNGFYYDVDLDRTLTQED-VEALEKRMHELAEKNYDVIKKKVSWHEARETFANRGESYK-----VSILDENIAHDDKPGLYFHEEYVDMCRGPHVPNMRFCHHFKLMKTADSNNKMLQRIYGTAWADKKALNAYLQRLEEAAKRDHRKIGK-EAPGMVFWHNDGWTIFRELEVFVRSKL-KEYQYQEVKGPFMMDRVLWEKTGHWDNYKDAMFTT---------------------------------SSENREYCIKPMNCPGHVQIFNQGLKSYRDLPLRMAEF-GSCHRNESGSLHGLMRVRGFTQDDAHIFCTEEQIRDEVNGCIRLVYDMYSTFGFEVKLSTRPEKRIGSDEMWDRAEADLAVALEYGPKIEFTLYDCLDRAWQCGTVQDFSLPSRLSASYVGEDNERKVPVMIHRAILGMERFIGILTEEFAGFFPTWLAPVQVVIMNITDSQSEYVNELT... 559
36 -16.5001nyq_A mol:protein length:645 threonyl-tRNA synthetase 1  ali model follow..  10  47..........VDLTKPLETDGSIEIVTEVLRHSTAHLMAHAIKRLYGNVKFGVGPVIEGGFYYDFDIDQNISSDD-FEQIEKTMKQIVNENMKIERKVVSRDEAKELFSNDEYKLELIDAIPEDENHVPSTAKIKEFKLLSTAGAYWRGDSNNKMLQRIYGTAFFDKKELKAHLQML------EERKERDHRKIGKELELF---TNSQLVGAGLPLWLPNGATIRREIERYIVDKE-VSMGYDHVYTPVLANVDLYKTSGHWDHYQEDMFPPMQLDETES-------------------------------MVLRPMNCPHHMMIYANKPHSYRELPIRIAEL-GTMHRYESGAVSGLQRVRGMTLNDSHIFVRPDQIKEEFKRVVNMIIDVYKDFGLSYRDPEDKEKYFDDDDMWNKAENMLKEAADYGPKLDVQVKTAMGKEETLSTAQDFLLPERFDLTYIGQDGEHHRPVVIHRGVVSMERFVAFLTEETKGAFPTWLAPKQVQI.................. 550
37 -16.4004tqd_A mol:protein length:291 Pyrrolysine--tRNA ligase  ali model follow..  21  75.............................................................................................................................................................................................................................GKLEREITRFFVDR-----GFLEIKSPILIPLEYIERMG-----------------------------------DNDTELSKQIFRVDKNFCLRPMLAPNLYNYLRKLDRALPD-PIKIFEI-GPCYRKESDGKE---HLEEFTMLSFIQMGSGCTR----ENLESIITDFLNHLGIDFKIVGDS---------------------------CMVYGDTLDVMHGDLELSSAVVGPIPLDREWGIDKP--------GAGFGLERLL---KVKHDFKN------IKRAARSES.............. 276
38 -16.3004q6g_A mol:protein length:267 Pyrrolysine--tRNA ligase  ali model follow..  19  57.............................................................................................................................................................................................................................GKLEREITRFFVD-----RGFLEIKSPILIPLEYIERMG----------------------------------IDNDTELSKQIFRVDKNFCLRPMVAPNIFNYAR-KLDRALPDPIKIFEI-GPCYRKESDGKE---HLEEFTMLNFFQMGSGCTR----ENLESIITDFLNHLGIDFKIVGDS---------------------------CSVYGDTLDVMHGDLELSSAVVGPIPLDREWGIDKP--------GAGFGLERLL---KVKHDFKN------IKRAARSES.............. 258
39 -15.8002e3c_A mol:protein length:291 Pyrrolysyl-tRNA synthetase  ali model follow..  19  65.......................................................................................................................................................................................................................IYAEERENYLGKLEREITRFF-VDRGFLEIKSPILIPLEYIERMG-----------------------------------DNDTELSKQIFRVDKNFCLRPMLAPNLYNYLRKLDRALPD-PIKIFEI-GPCYRKESDGKE---HLEEFTMLNFCQMGSGCTR----ENLESIITDFLNHLGIDFKIVGDS---------------------------CMVYGDTLDVMHGDLELSSAVVGPIPLDREWGIDKP------WIGAGFGLERLLKVKHDFKNIKR............................. 270
40 -15.5001ati_A mol:protein length:505 GLYCYL-TRNA SYNTHETASE  ali model follow..  15  29...................................................................................................................................................................................................................QGVYDYGPLGVELKNNLKQAWWRRNVERDDMEGLDASVLTHRLVLHYSGHEATFADPMVDNRITKKRYRLDHLLKEQPEEVLKRLYRAMEVEEEN-RGLLAYLRPETAQGIFVNFKNVLATSRKLGFGIAQI-GKAFRNEITPRNFIFRVREFEQMEIEYFVRPGEDEYWHRYWVEERLKWWQEMGL--------SRENLVPYQQPPESSAHYAKATVDILYRFPHGSLELEGIAQRTDFDLGSHTKDQEALRDPETGKWFVPYVIEPSAGVDRGVLALLAE.................................. 374
41 -15.3003l4g_A mol:protein length:508 Phenylalanyl-tRNA synthetase alpha chain  ali model follow..  12  1MADGQVAELLLRRLEASDGGLDSAELAAELGMEHQAVVGAVKSLQALGEVIEAELRSTKHWELTAEGEEIAREGSHEARVFRSIPPE-LPSGKVGFSKAMSNKWIRVDKSAADGPRVFRVVDSMEDEVQRRLQLVRGGQAEKLGEKERSELRKRKLLAEVTLKTYWVSKGSAFSTSISKQETELSPEMISSGSRDRPFKPYNFLAHGVLPDSG----LHPLLKVRSQFRQIFLEM-SSFWNFDALFQPQQHPARDQHDTFFLRD--------AEALQLPMDYVQRVKRTHSQGGYGSQGYKYNWKLDEARKNLLRTHTTSASARALYRLAQKKPFTPVKYFSI-DRVFRNET----DATHLAEFHQIEGVVADHGLTLGHLMGVLREFFTKLGIT---QLRFKPAYNPY---------------TEPSMEVFSYHQGLKKW------VEVGNSGVFRPEMLLPMGLPENVSVIAW----GLSLERPT---MIKYGINN------IRNLQMVYDSPLCRLDAEPRPPP 503
42 -14.9004cs2_A mol:protein length:274 PYRROLYSINE--TRNA LIGASE  ali model follow..  19  48.......................................................................................................................................................................................................................IYAEERENYLGKLEREI-TRFFVDRGFLEIKSPILIPLEYIERMG-------------------DNDTELSKQIFRVDK----------------NFCLRPMLAPNLANYLRKLDRALPD-PIKIFEI-GPCYRKESDGKE---HLEEFTMLNFCQMGSGCTR----ENLESIITDFLNHLGIDFKIVGDSCMVFGDTLDVMHGDLELSSAVVGPIPL.............................................................................................. 221
43 -14.6002zni_A mol:protein length:308 Pyrrolysyl-tRNA synthetase  ali model follow..  15  78.......................................................................................................................................................................................................................LRTVKHRPALLELEEK-LAKALHQQGFVQVVTPTIITKSALAKMT-------------------GEDHPLFSQVFWLDG----------------KKCLRPMLAPNLYTLWR-ELERLWDKPIRIFEI-GTCYRKESQGAQ---HLNEFTMLNLTELGTP--LEERHQRLEDMARWVLEAAGI--------------------------REFELVTESSVVYGDTVDVMKGDLELASGAMGPHFLDEKWEIFDP---------LGFGLERLLMIREGTQHVQSMARSLSYLD.................... 295
44 -14.3004bw9_A mol:protein length:291 PYRROLYSINE--TRNA LIGASE  ali model follow..  17  65.......................................................................................................................................................................................................................IYAEERENYLGKLEREI-TRFFVDRGFLEIKSPILIPLEYIERMG-------------------DNDTELSKQIFRVDK----------------NFCLRPMLAPNLGNYLRKLDRALPD-PIKIFEI-GPCYRKESDGKE---HLEEFTMLNFCQMGSGCTR----ENLESIITDFLNHLGIDFKIVGDSCMVFGDTLDVMHGDLELSSAVVGPRPL-----DREWGIDKPWIGAGFGLERLLKVKH-NIKRAARSESYYNGISTNL............................................ 285
45 -14.0003qtc_A mol:protein length:290 Pyrrolysyl-tRNA synthetase  ali model follow..  18  4............................................................................................................................................................GLVPRGSHGASAPALTKSQTDRLEVLLNPKDEISLNSGKPFRELESELLSRRKKDLQQIYAEERENYLGKLERE--ITRFFVDRGFLEIKSPILIPLEYIERMG-------------------DNDTELSKQIFRVDK----------------NFCLRPMLTPNLYNYLRKLDRALPD-PIKIFEI-GPCYRKESDGKE---HLEEFTMLVFWQMGSGCT----RENLESIITDFLNHLGIDFKIVGDSCMVFGDTLDVMHGDLELSSALVGPIPL.............................................................................................. 235
46 -11.2002pme_A mol:protein length:693 Glycyl-tRNA synthetase  ali model follow..  11  8..........................................................................EVLAPLRLAVRQQ-GDLVR-------------KLKEDKAPQVDVDKAVAELKARKRVLEAKELALQPKDDIVDRAKMEDTLKR----------------------------------------RFFYDQAFAIYGGVSGLYDFGPVGCALKNNIIQTWRQHFIQEEQILEIDCTMLTPEPVLKTSGHVDKFADFMVLMSDKKCSVEKKSEMESVLAQLDNYGQQELADLFVN-GNMPGYLRPETAQGIFLNFKR-EFNQGKLPFAAAQI-GNSFRNEISPRSGLIRVREFTMAEIEHFVDPSEKDHEQGVINNTVLGYFIGRIYLYLTKVGISPDKLRFRQHMENEMAHYACDCWDAESKTSYGWIEIVGCADRSCYDLSCHAINVKRFQKTLYVEEVVPNVIEPSFGLGRIMYTVFEHTEGDEQRTFFSFPAVVAPFKCSVLPLSQNQEFMP 575
47 -9.9701nnh_A mol:protein length:294 asparaginyl-tRNA synthetase-related peptide  ali model follow..  14  12..........................................................................................................................................................................................................................SPTLDIQTKILEYMTDFFVKE-GFKWLLPVIISPITD----------------------------------PLWPDPAGEGMEPAEVEIYGVKMRLTHSMILHKQLAIAMG--------LKKIFVLSPNIRLESRQKDDGRHAYEFTQLDFVERAKMEDIMRLIERLVYGLSEVLEEFGSDEKASQMEEPFWIINIPREFYDREVDGFWRNYDLILPYGYGEVASGGEREKIRKAGLNEDSFRPYLEIAKAGKLKPSAG-AGIGVERLVRFIV-----------------------GAKHIAEVQPFPR 286
48 -9.89011as_A mol:protein length:330 ASPARAGINE SYNTHETASE  ali model follow..  9.............................................................................................................................................................................................................................QRQISFVKSHFSRQLEERLGLIEVQAPILSRVG------------------DGTQDNLSGAEK--------------AVQVKVKALPDAQFEVVHSLAKWKRQTLGQHDFSAGE---GLYTHMKALRPDEDRLSP--LHSVYVDQWDWRVMGDGERQFSTLKSTVEAIWAGIKAVHSQELLSRYPDLDAKGRERAIAKDLGAVFLVGIGGKLSTPSELGHAGLNGELSSMGIRVDADTLKHQLALTGDEDRLELTIGGGIGQSRLTMLLLQLPHIGQGVWPAAVRESVPSLL.............. 330
49 -9.6801b70_A mol:protein length:350 PHENYLALANYL-TRNA SYNTHETASE  ali model follow..  11  2.....................................................................................................................LEEALAAIQNARDLEELKALKARYLGKKGLLTQEMKGLSALPLEERRKRGQELNAIKAALEAALEAREKAEEAALKEALERERVDVSLPGASLFSGGL---HPITLMERELVEIFRAL-SEFFNFDALNIPEHHPARDMWDTFWLTG-------------------------------EGFRLEGPLGEEVEGRLLLRTHT-----SPMQVRYMVAHTPPFRIVVP-GRVFRFEQ----DATHEAVFHQLEGLVVGEGIAMAHLKGAIYELAQALFGP-DSKVRFQPVYFPF---------------VEPGAQFAVWWPEGGKWLELGGAGMVHPKVFQAVDAYRERLGLPPAYRGVTGFAFGLGVERLA---MLRYGIPD............................. 331
50 -9.3503p8t_A mol:protein length:294 AsnS-like asparaginyl-tRNA synthetase related protein  ali model follow..  15  13...........................................................................................................................................................................................................................KAIDIQTKILDYMTKFFTDR-GFKWLLPIMLSPITD----------------------------------PLWPDPAGEGIRPAEVDVYGVRMRLTHSMILHKQLAIAMGL--------KIFVL-SPNIRLESRRKDDGRHSYEFTQLDFIEGAKMKDVMRLIEELIYGLKDILEEFGSDEKASMMEEPFWIVNIPREFYDREENGVWKNYDLILPYGYGEVSSGGEREKIRAAGLKEDSFRPYLEIARAGKLKPSAG-AGIGVERLVRFIV-----------------------GAKHIAEVQPFPR 286

FFAS is supported by the NIH grant R01-GM087218-01
1 2 7 7 6 3   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Awobuluyi M, Yang J, Ye Y, Chatterton JE, Godzik A, Lipton SA, Zhang D. Subunit-specific roles of glycine-binding domains in activation of NR1/NR3N-methyl-D-aspartate receptors. Mol Pharmacol. 2007 Jan;71(1):112-22. Epub 2006 Oct 17.