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Query: 4rhi_A mol:protein length:351 Arginase, from PDB1018

Results of FFAS03 search in PDB1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MGSSSSGLVPRGSHMFSKFLMNVKGVTPRGSDWANRLGPVALFGYGAGMPRRAPLLDFFLQSPRDCDHYAELTIHDKGPIECPPETVMFMPVLNCGQMLDEAAGTETPTSDEWYLGSLEASTELLEKGYVPVSVGGDGSATLSMVEAYKRLFPSDDIVIVHFSARPSVSDPRSPLRVLLDKGLLKGVVSVGNRQVSSEDRKVRKLHKMFYMDMHAIYSKGLFCIRDIRNDYPVFISIDASVLDPAFAPAVDSPVAGGLSTRDLLHIMNGIRGPKVVGIDVYGYNPDLDVYRKDNVGLTAIALSKIIKEGILKAYSISTHTEEEGMERVKMLQRQGTVSENPYPDHLast
1 -105.0004rhi_A mol:protein length:351 Arginase  ali model  100  1MGSSSSGLVPRGSHMFSKFLMNVKGVTPRGSDWANRLGPVALFGYGAGMPRRAPLLDFFLQSPRDCDHYAELTIHDKGPIECPPETVMFMPVLNCGQMLDEAAGTETPTSDEWYLGSLEASTELLEKGYVPVSVGGDGSATLSMVEAYKRLFPSDDIVIVHFSARPSVSDPRSPLRVLLDKGLLKGVVSVGNRQVSSEDRKVRKLHKMFYMDMHAIYSKGLFCIRDIRNDYPVFISIDASVLDPAFAPAVDSPVAGGLSTRDLLHIMNGIRGPKVVGIDVYGYNPDLDVYRKDNVGLTAIALSKIIKEGILKAYSISTHTEEEGMERVKMLQRQGTVSENPYPDH 345
2 -102.0004rhm_A mol:protein length:351 Arginase  ali model follow..  98  1MGSSSSGLVPRGSHMFSKFLMNVKGVTPRGSDWANRLGPVALFGYGAGMPRRAPLLDFFLQSPRDCDHYAELTIHDKGPIECPPETVMFMPVLNCGQMLDEAAGTETPTSDEWYLGSLEASTELLEKGYVPVSVGGDGSATLSMVEAYKRLFPSDDIVIVHFDAHPDVSDPRSPLRVLLDKGLLKGVVSVGNRQVSSEDRKVRKLHKMFYMDMHAIYSKGLFCIRDIRNDYPVFISIDADVLDPAFAPAVDSPVAGGLSTRDLLHIMNGIRGPKVVGIDVYGYNPDLDVYRKDNVGLTAIALSKIIKEGILKAYSISTHTEEEGMERVKMLQRQGTVSENPYPDH 345
3 -78.6003nio_A mol:protein length:319 Guanidinobutyrase  ali model follow..  19  14.MPRFGGIATMMRLPHVDALDAAFVGVPLDLRSGTRFGPREIRAESVMIRPYNMATG--------AAPFDSLNVADIGDVAINTFN-----------------------LLEAVRIIEQEYDRILGHGILPLTLGGDHTITLPILRAIKKKH--GKVGLVHVDAHADVNDHGTTFRRAVEEDLLDRVVQIGLRAQTAEDFNWSRKQGFRVVQAEECWHKSMAEVREKVGGGPVYLSFDIDGIDPAWAPGTGTPEIGGLTTIQAMEIIRGCQGLDLIGCDLVEVSPPYD-----TTGNTSLLGANLLYEMLCVLPGVVRR.......................... 319
4 -78.5001gq6_A mol:protein length:313 PROCLAVAMINATE AMIDINO HYDROLASE  ali model follow..  20  8VSPRYAQIPTFMRLPHDRGYDVVVIGAPYDYRPGARFGPQAIRSESGLIHGVGIDRG--------PGTFDLINCVDAGDINLTPFD-----------------------MNIAIDTAQSHLSGLLKANAAFLMIGGDHSLTVAALRAVAEQH--GPLAVVHLDAHSDTNPHGTPFRHGIDEKLIAAMVQIGIRGHKPDSLDYARGHGVRVVTADEFGELGADLIREKVGQRPVYVSVDIDVVDPAFAPGTGTPAPGGLLSREVLALLRCVGDLKPVGFDVMEVSPLYD-----HGGITSILATEIGAELLYQYARAHRTQ......................... 312
5 -78.2004dz4_A mol:protein length:324 Agmatinase  ali model follow..  21  25IENTYAGVLSFMRRNYTDGVDVVVSGVPLDFRSGARLGPSAVRAASVQLAELNPYPW-------GFDPFDDLAVIDYGDCWFDAHH-----------------------PLSIKPAIVEHARTILQSDARMLTLGGDHYITYPLLIAHAQKYG-KPLSLIHFDAHCDTWAHGTMFYKAVKDGLIKASVQVGIRTWNDDYL------GINVLDAAWVHEHGLERIESIVGGRPAYLTFDIDCLDPAFAPGTGTPVAGGLSSAQALAIVRGLGGVNLIGADVVEVAPAYD-----QSEITAIAAAHVACDLLCLWRQRKAGAR........................ 324
6 -77.3003pzl_A mol:protein length:313 Agmatine ureohydrolase  ali model follow..  19  10.KDHASELRSIFSLKKIEEAKYVVFGIPFDYRRGSKYAPDSIRGAYVNLESYEYSYGIDLL---------ASGMADLGDMEES------------------------EDVEYVIDTVESVVSAVMSDGKIPIMLGGEHSITVGAVRALPK-----DVDLVIVDAHSDFRSHACVTRRALDLLGEGRITSIGIRSVSREEFEDPDFRKVSFISSFDVKKNGIDKYIEEVKSRRVYISVDMDGIDPAYAPAVGTPEPFGLADTDVRRLIERL-SYKAVGFDIVEFSPLYD------NGNTSMLAAKLLQVFIASREKYYKEHIEG...................... 307
7 -77.1003nip_A mol:protein length:326 3-guanidinopropionase  ali model follow..  22  15..PRFAGIPTFMRLPAFAALQVGLIGVPWDNRAGARHGPREVRNLSSLMRKVHHVSR--------IAPYDLVRVGDLGDAPVNPID-----------------------LLDSLRRIEGFYRQVHAAGTLPLSVGGDHLVTLPIFRALGRE---RPLGMVHFDAHSDTNDHGTPFRRAIEEGLLLRTVQIGIRGSSPDDDAFARECGIRVIHMEEFVELGLAEARRVVGAGPTYVSFDVDVLDPAFAPGTGTPEIGGMTSLQAQQLVRGLRGLDLVGADVVEVSPPFD-----VGGATALVGATMMFELLCLLAESAARSALE...................... 320
8 -76.4001wog_A mol:protein length:305 agmatinase  ali model follow..  18  6.HLPYGGIPTFARAPLVQQADVAALGVPFDFRPGARFAPRALREASLRSVPPFTGLDGK-------TRLQGVTFADAGDVILPSLE-----------------------PQLAHDRITEAARQVRGRCRVPVFLGGDHSVSYPLLRAFADV---PDLHVVQLDAHLDFTDNSSPFRRACEALPLVHITTVGLRGLDPEAVAAARARGHTIIPMDDVTADLAGVLAQLPRGQNVYFSVDVDGFDPAVIPGTSSPEPDGLTYAQGMKILAAAANNTVVGLDLVELAPNLD-----PTGRSELLMARLVMETLCEVFDHV............................ 304
9 -75.4003lhl_A mol:protein length:287 Putative agmatinase  ali model follow..  19  6.................EESNLIVFGVGFDNRPGARFASSSMRKEFYGLETYSPFLDLD---------LEDYNICDYGDLEISVGS-----------------------TEQVLKEIYQETYKIVRDSKVPFMIGGEHLVTLPAFKAVHEKYN--DIYVIHFDAHTDLREHATVIKRIWDIVGDNKIFQFGIRSGTKEEFKFATEEKHTYMEIGGID---FENIVNMLNGKNIYLTIDLDVLDASVFPGTGTPEPGGVNYREFQEIFKIISNINIVGCDIVELSPDYD-----TTGVSTVIACKILRELCLIISDKIKEG......................... 281
10 -67.3003m1r_A mol:protein length:322 Formimidoylglutamase  ali model follow..  19  16.SFKDRDVTKMSDLIATDIKGPALIGVPLSSHSGASFAPGTIRQALKHSSAYSAELGEH---------VVSELLYDLGDIDIHVTDI-----------------------VKSHHHIFQTMHALLSDHPVPLILGGDNSISYSTIKAIAQTK--GTTAVIQFDAHHDVRNNGTPFRRLLDEEIIEHLIQLGIREFSQAYEAYAKKHNVNIHTMDMIREKGLIPTIKEIKTDFIFISVDMDVLDQSHAPGCPAIGPGGLYTDELLEAVKYIQQPNVAGIEIVEVDPTLDF-----RDMTSRAAAHVLLHALKGMKLSPFK.......................... 322
11 -67.0002a0m_A mol:protein length:316 ARGINASE SUPERFAMILY PROTEIN  ali model follow..  16  4..AARTDDPRLLSLFSAQREEDAIVIIGFPYDAGAKKGPAAFRFFLQRLGSVNNLELN--------VDASHLKLYDAGDITA-------------------------STLEEAHEKLESKVFTVLARGAFPFVIGGGNDQSAPNGRAMLRAFP-GDVGVINVDSHLDVRHSGTPFRQLLEESSFSRFVEFACQGSGALHAQYVRDHQGHLMWLSEVRKKGAVAALEDA-GKNTFFSFDVDSLKSSDMPGVSCPAAVGLSAQEAFDMCFLAKTPTVMMMDMSELNPLVE------EYRSPRVAVYMFYHFVLGFATRPKPKAEN...................... 310
12 -65.1005ynl_A mol:protein length:362 Arginase  ali model follow..  17  25MDSPDLGTDDDDKMSPATSRTAGIVGCPFSPKAGVHSGPLQLIESGLLNDIENLGWTVD---FAGADALAVSIVSDTPDPDIGRLKQP-------------------RLVSRVTKDVADRVYAHASKGQLTVTLGGDHSLAMGTVSGTFKAYP--EACLIWVDAHADINTHGCPVSFLLGLDGTERIVYIGLRDIDAGERKILKDNNIKCFSMFHVDKYGIGKVVEMARTRPIHLSFDVDALDPSVAPSTGTAVRGGLTFREGHYICEAIETNLLVSLDIMEINPSLG--ALASVAQTVDVGRSLVRCALGETL............................... 355
13 -63.9001pq3_A mol:protein length:306 Arginase II, mitochondrial precursor  ali model follow..  18  2....................SVAVIGAPFSKRKGVEHGPAAIREAGLMKRLSSL----------------GCHLKDFGDLSFTPVPKDDLYN---------NLIVNPRSVGLANQELAEVVSRAVSDGYSCVTLGGDHSLAIGTISGHARHCP--DLCVVWVDAHADINTHGQPVSFLLRELQSASIVYIGLRDVDPPEHFILKNYDIQYFSMRDIDRLGIQKVMERTRQRPIHLSFDIDAFDPTLAPATGTPVVGGLTYREGMYIAEEIHNTLLSALDLVEVNPQLA-----TSEEEAKTTANLAVDVIASSFGQTREG......................... 306
14 -63.2002eiv_A mol:protein length:291 Arginase  ali model follow..  22  4.......................VAVVGVPMDRGVDMGPSALRYARLLEQLED----------------LGYTVEDLGDVPVSLARASRRRGRGLAYLEEI----------RAAALVLKERLAALPEGVFPIVLGGDHSLSMGSVAGAAR---GRRVGVVWVDAHADFNTHGMPLAVLSGLGHPKDVVLVGVRSLDPGEKRLLKEAGVRVYTMHEVDRLGAEEVLKHLQGLPLHVSLDADVLDPTLAPGVGTPVPGGLTYREAHLLMEILESGRVQSLDLVEVNPILD-----ERNRTAEMLVGLALSLLGKRI............................... 290
15 -62.9001d3v_A mol:protein length:323 PROTEIN (ARGINASE)  ali model follow..  18  4.................KPKPIEIIGAPFSPRGGVEKGPAALRKAGLVEKLKETEYN--------VRDHGDLAFVDVPNDSPFQ------------------IVKNPRSVGKANEQLAAVVAETQKNGTISVVLGGDHSMAIGSISGHARVHP--DLCVIWVDAHTDINTHGQPVAFLLKELKAKDIVYIGLRDVDPGEHYIIKTLGIKYFSMTEVDKLGIGKVMEETKKRPIHLSFDVDGLDPVFTPATGTPVVGGLSYREGLYITEEIYKTLLSGLDIMEVNPTLG-----KTPEEVTRTVNTAVALTLSCFGTKREGNHKPETDYLKPPK............ 323
16 -62.9001wva_A mol:protein length:322 Arginase 1  ali model follow..  17  4.................KSRTIGIIGAPFSPRGGVEEGPTVLRKAGLLEKLKE----------------QECDVKDYGDLPFA----------DIPNDSPFQIVKNPRSVGKASEQLAGKVAEVKKNGRISLVLGGDHSLAIGSISGHARVHP--DLGVIWVDAHTDINTHGQPVSFLLKELKAKDIVYIGLRDVDPGEHYILKTLGIKYFSMTEVDRLGIGKVMEETKKRPIHLSFDVDGLDPSFTPATGTPVVGGLTYREGLYITEEIYKTLLSGLDIMEVNPSLG-----KTPEEVTRTVNTAVAITLACFGLAREGNHKPIDYLNPPK............. 322
17 -62.7001t5f_A mol:protein length:314 Arginase 1  ali model follow..  18  3.......................IEIIGAPFSGGVEKGPAALRKAGLVEKLKETEYN--------VRDHGDLAFVDVPNDSPFQ------------------IVKNPRSVGKANEQLAAVVAETQKNGTISVVLGGDHSMAIGSISGHARVHP--DLAVIWVDAHTDINTAGQPVAFLLKEL-AKDIVYIGLRDVDPGEHYIIKTLGIKYFSMTEVDKLGIGKVMEETKKRPIHLSFDVDGLDPVFTPATGTPVVGGLSYREGLYITEEIYKTLLSGLDIMEVNPTLG-----KTPEEVTRTVNTAVALTLSAFGTKREGNHKPETD.................. 312
18 -59.3004q3p_A mol:protein length:385 Arginase  ali model follow..  15  9VPRGSHMMLKSVATPYPKLLYTSANFLGIPTNIGTYQGPELIRKSNFFQLVAE----------------DGIQLTDCGDIIPVELNEAEDFGMKWSRSFSLTTLRIAERVEELMKQSNKHTVELSGSKSTPVIVGGDHSMATGTILGHAEAKP--DLCVLWIDAHGDINTHGMPLSFLVKEL-ASNIAYIGLRDLDAHETHDIRKHGIAYFTMLDVDRMGIEAVIKEALEKAIHLSFDIDALDPLVAPSTGTAVPGGLTLREGLRICEEVSATKLSVVELAELNPLLG--SQEDVLKTQSSAVHILRACLGHCRSGHLPFKVRNLTDQGIMSRAAHMQTKQ.... 379
19 -58.9004ity_A mol:protein length:330 Arginase  ali model follow..  18  3................GSGMAKKMSIVLAPFSSGVELGPDYLLKQGLQQDMEKLGWDTRLERVFDGKVVEARKASDNGDRIGRVKRPR--------------------LTAECTEKIYKCVRRVAEQGRFPLTIGGDHSIALGTVAGVLSVHP--DAGVIWVDAHADINTHGCPLSILLGLDRPNKIAYIGLRAVDDEEKKILHDLNIAAFSMHHVDRYGIDKVVSMAGTEPVMVSYDVDTIDPLYVPATGTPVRGGLSFREALFLCERIECGRLVALDVVECNPLLA-----ATESHVNDTISVGCAIARCMMGETLLYTPHTSSK.................. 323
20 -58.7006dkt_A mol:protein length:296 Arginase  ali model follow..  19  1...................MDKTISVIGMPMDRGVDMGPSAIRYAHLIERLSD----------------MGYTVEDLGDIPINREKIKNDEELK-----------NLNSVLAGNEKLAQKVNKVIEEKKFPLVLGGDHSIAIGTLAGTAKHYD--NLGVIWYDAHGDLNTHGMPLAVSLGIG-PENVVIIGARSLDEGERKYIKESGMKVYTMHEIDRLGMTKVIEETACDGVHLSLDLDGLDPNDAPGVGTPVVGGISYRESHLAMEMLYDAIITSAEFVEVNPILD-----HKNKTGKTAVELVESLLGKKL............................... 295
21 -58.3001cev_A mol:protein length:299 PROTEIN (ARGINASE)  ali model follow..  18  4.......................ISIIGVPMDRGVDMGPSAMRYAGVIERLER--LHYDIEDLGDIPIGKAERLHEQGDSRLRNLK----------------------AVAEANEKLAAAVDQVVQRGRFPLVLGGDHSIAIGTLAGVAKHYE--RLGVIWYDAHGDVNTHGMPLAASLGFG-PEHVVLIGVRSLDEGEKKFIREKGIKIYTMHEVDRLGMTRVMEETRTDGVHLSLDLDGLDPSDAPGVGTPVIGGLTYRESHLAMEMLEAQIITSAEFVEVNPILD-----ERNKTASVAVALMGSLFGEKL............................... 298
22 -57.4004g3h_A mol:protein length:330 Arginase (RocF)  ali model follow..  11  1.......................MILVGLEAERGTDKGVRRLREALSATHGDV------IKGMQTITQERCVLYKEFRYAKNFEDYY-----------------------LFCKENLIPCMKEVFEKKEFPLILSSEHANMFGIFQAFRSVHKDKKIGILYLDAHADIHTHGMPLGMVLNRVRSKCLVYFGVRSTEQSERDVIRELQIPLFSVDAIRE-NMQEVVQKTAVDIIYLSLDLDIMDGKLFTSTGVRENNGLSFDELKQLLGLLLESRLKAVEVTEYNPTVSIKHNNE---EEKQVLEILDLIINSCKIKDKKHSFAR..................... 320
23 -56.9001xfk_A mol:protein length:336 Formimidoylglutamase  ali model follow..  13  23.GRRVHHIACPIQVGELANQEPGVALIGFECDTGAKHAPSLIKQALANLAWHH-----------------PIPIYDLGNIRCEGDEL-----------------------EQAQQECAQVIQQALPHA-RAIVLGGGHEIAWATFQGLAQHFLAPRIGIINFDAHFDLRSSGTPFNQIHHFCQQQHYACLGVSRATPALFERADKLGVWYVEDKAFSPLSLKDHLTQLQHDYLYLTIDLDVFPAASAPGVSAPAARGVSLEALAPYFDRILHYKLMIADIAEYNPSFDI-----DQHTARLAARLCWDIANAMAEQVQSIRH....................... 335
24 -54.2003mmr_A mol:protein length:413 Arginase  ali model follow..  14  90.....................DNNNDNNNDNNNNCYIPNGVIKEKKHDLSNNKMNGYVN---HNFYGNYEENNVISTNDKYKNNCYYDNIRNIK--------------EIGIFSKNLFDTMSNELRKKNFVLNIGGDHGVAFSSILSSLQMYQ--NLRVIWIDAHGDINIHGMTLAHTLGLFKKENTAIIGIRDIDAYEKIILKKCNINYYTIFDIEKNGIYNTICTASNCPIHISLDIDSVDNVFAPGTGTVAKGGLNYREINLLMKILETKRVVSMDLVEYNPSLD-----EVDKKVHGDSLPILDNATKTGKLCLE.......................... 396

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Pawlowski K, Pio F, Chu Z, Reed JC, Godzik A. PAAD - a new protein domain associated with apoptosis, cancer and autoimmune diseases. Trends Biochem Sci. 2001 Feb;26(2):85-7.