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Query: 4p3n_A mol:protein length:415 Threonine--tRNA ligase, cytoplasmic, from PDB1018

Results of FFAS03 search in PfamA32U
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MGSSSSGDHRKIGRDQELYFFHELSPGSCFFLPKGAYIYNALIEFIRSEYRKRGFQEVVTPNIFNSRLWMTSGHWQHYSENMFSFEVEKELFALKPMNCPGHCLMFDHRPRSWRELPLRLADFGVLHRNELSGALTGLTRVRRFQQDDAHIFCAMEQIEDEIKGCLDFLRTVYSVFGFSFKLNLSTRPEKFLGDIEVWDQAEKQLENSLNEFGEKWELNSGDGAFYGPKIDIQIKDAIGRYHQCATIQLDFQLPIRFNLTYVSHDGDDKKRPVIVHRAILGSVERMIAILTENYGGKWPFWLSPRQVMVVPVGPTCDEYAQKVRQQFHDAKFMADIDLDPGCTLNKKIRNAQLAQYNFILVVGEKEKISGTVNIRTRDNKVHGERTISETIERLQQLKEFRSKQAEEEFLast
1 -83.600PF00587.25; SYT_ECOLI/318-529; tRNA synthetase class II core domain (G, H, P, S and T)  ali follow..  52  1..................................................................................FTTSSENREYCIKPMNCPGHVQIFNQGLKSYRDLPLRMAEFGSCHRNEPSGSLHGLMRVRGFTQDDAHIFCTEEQIRDEVNGCIRLVYDMYSTFGFEIVVKLSTRPEKRIGSDEMWDRAEADLAVALEENNIPFEYQLGEGAFYGPKIEFTLYDCLDRAWQCGTVQLDFSLPSRLSASYVGEDNER-KVPVMIHRAILGSMERFIGILTEEF................................................................................................................... 212
2 -19.300PF03129.20; W5ALZ8_WHEAT/796-880; Anticodon binding domain  ali follow..  20  1.....................................................................................................................................................................................................................................................................................................................VSILGKDLILAAELVNELWSAGIKAEFKL--TTRVQNHIKYATQTGIPWMVLVGESELRDGKVKLKDIRANQEEEVPRKDFVEVLKQ............. 85
3 -10.200PF13393.6; G2IXI8_PSEUL/10-315; Histidyl-tRNA synthetase  ali follow..  11  4..............................ILPATARQVESAKAAMLELFRTAGYELVLPPLIEYADALVSEDSALDIKTFKLDDHLSGRQLGLRADITPQVARIDAHLLSN-RTGVTRLCYAGSVVHARPSGL-----SSREPLQVGAELYGYAGIEAD--LEIIELMLATLRQVGVDKLRLDVGHIRGLAAAAGLAAEDTRELFGALQSKDITVRELVAEVAEPYKSAFLALPELYGPRQVLDKARTRLEVELGLMQLTAIANALDGQVELSFDLAELRGDFYHTGLMFAAY--------APGWSEALARGGRYDNVGRKFGRARPATGFSLDLR........................................................................ 304
4 -9.490PF12745.7; Q6FSE4_CANGA/1377-1646; Anticodon binding domain of tRNAs  ali follow..  13  1............................................................................................................................................................................................................................................................................................................WKPSRDVLVSSFSNSIFTIGVNILNQLWKNGIKADFLRN-CYTVDDVVSGAQQDGVDWIVLIKQQSTKYKPLKVKHLGSDIDVDVTLEEFLVLYRQETTRKLGV..... 111
5 -6.820PF05367.11; A0ZXJ0_9CAUD/1-149; Phage endonuclease I  ali follow..  13  17......................................................................................................................................................................................................SGLEEKNMKLLESKGVKAE--------YEMWRVPYVVPASNHHYT------DILLPNGIFVETKGLWESDDRKKHLLIREQYPDLDIRL-------------------VFSSSRTKIYKGSPTSYAEFCEKHGILFADKLIPVAWLKEASRPVPFDKL..................................................... 142
6 -6.660PF00152.20; SYDND_NEIMB/118-567; tRNA synthetases class II (D, K and N)  ali follow..  16  1.SENVRLTNRVIDLRRP--------------MQRNLRLRYQVAMGVRRYLDAQGFIDIETPMLTRS------------------TPEGARDYLVPSRVHPGEFFALPQSPQLFKQLLMRYYQITKCFRDEDLRA----DRQPEFTQIDLETFLNEDEIMDITEGMAQVFKDALNVDLGDFPRMPYSEAMFYYGSDK..................................................................................................................................................................................................................... 167
7 -5.630PF17303.2; Q20769_CAEEL/22-186; Family of unknown function (DUF5352 topsan)  ali follow..  12  4.......................................................................TGHWMFSLAEGVTDYSYGGSKLNTKYYCFEGCLNTGTALQNYKILLAGTNATMLERTRPVKDIVSLHSQAVVRDDDPNAEFCVDDTLRNDVKNALQKS------------------------TKNTCKNIVNTLVLNLNRPGWAITCIQ-DGVVTDKNFCSYDAVQNGEIFTIRLAKLDMS............................................................................................................................................................. 165
8 -5.130PF12483.8; Q8DL39_THEEB/91-248; E3 Ubiquitin ligase  ali follow..  14  1..................................................................................................................................................................................................................................................................VYKTTESHEDGSSETKYRHEILSSNTQTIPFRLRDGDMEIYVDPRGAEIETVQVLNEFQEDNNTTHLAFGRFQMDLSSLPKHSDTVGYRYEEWILPVNQQVFVVGTASDERGKLRIRRPHQKGQLFFISLESEENLTKKVRQYA....... 144
9 -4.990PF12608.8; D3HLA8_LEGLN/4-102; Type IVb secretion, IcmS, effector-recruitment  ali follow..  13  1.........................................................................................................................................................................................................................................................................................DISKCMAVIAASLNAKFYL-VSFEEVFLLPA---IAKRADQLCSLCLGYGLGATFDEAEGALLGLRVVFDEVTPNVLRLLC............................................... 85
10 -4.940PF13676.6; I1YI89_METFJ/5-127; TIR domain  ali follow..  13  1...................................................................................................................................................................................................................................................................................................................IFLSHTHADKPFVRKLASDLEAHGIRYWLDIKVGESLIEKIRHGLDTVDYVAAILSPNSIASPWVQRE.................................. 71

FFAS is supported by the NIH grant R01-GM087218-01
1 2 7 7 1 2   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Friedberg I. and Godzik A Connecting the Protein Structure Universe by Using Sparse Recurring Fragments. Structure (Camb.) (2005) Aug;13(8):1213-24