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Query: 2e3c_A mol:protein length:291 Pyrrolysyl-tRNA synthetase, from PDB1018

Results of FFAS03 search in SCOP207
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MGSSSSGLVPRGSHMASAPALTKSQTDRLEVLLNPKDEISLNSGKPFRELESELLSRRKKDLQQIYAEERENYLGKLEREITRFFVDRGFLEIKSPILIPLEYIERMGIDNDTELSKQIFRVDKNFCLRPMLAPNLYNYLRKLDRALPDPIKIFEIGPCYRKESDGKEHLEEFTMLNFCQMGSGCTRENLESIITDFLNHLGIDFKIVGDSCMVYGDTLDVMHGDLELSSAVVGPIPLDREWGIDKPWIGAGFGLERLLKVKHDFKNIKRAARSGSYYNGISTNLLast
1 -45.300d1jjca_ d.104.1.1 (A:) Phenyl-tRNA synthetase (PheRS) alpha subunit, PheS {Thermus thermophilus [TaxId: 274]}  ali model 3D-neighbors follow..  14  1..........RVDVSLPGASLFSGGLHPITLMERELVEIFRALG--YQAVEGPEVESEFFNFDALNIPEHHPAR-----DMWDTFWLTG--------------------EGFRLEGPLGEEVEGRLLLRTHTSPMQVRYMVAHT----PPFRIVVPGRVFRFEQTDATHEAVFHQLEGLVVGEGIAMAHLKGAIYELAQALFGPDSRFQPVYFPFVEPGAQFGKWLELGGAGMVHPKVFQAVDAYRERFAFGLGVERLAMLRYGIPDIRYFFGGRLKF....... 258
2 -39.200d1wu7a2 d.104.1.1 (A:3-329) Histidyl-tRNA synthetase (HisRS) {Thermoplasma acidophilum [TaxId: 2303]}  ali model 3D-neighbors follow..  14  1....................................................RLQIEKIRGFRDFYPEDMD-VEKFIFKTAEEAAEAFGFRRIDFPSLEYLDLYIKSGEELLQQTYSFVDKGGREVTLIPEATPSTVRMVTSR-KDLQRPLRWYSFPKVWRYEEPQAGRYREHYQFNADIFGSDSPEADAEALASSILDRLGLQYEIRINSRKIMEEIIGGMTSSDPFSFSIIDRYHKISREEFVDQLRSAGIGEDGVSMIADLCSGTRGI.............. 223
3 -37.800d1h4vb2 d.104.1.1 (B:2-325) Histidyl-tRNA synthetase (HisRS) {Thermus thermophilus [TaxId: 274]}  ali model 3D-neighbors follow..  20  3........................................................RAVRGTKDLFGKELR-MHQRIVATARKVLEAAGALELVTPIFEETQVFEKGVGAATDEMFTFQDRGGRSLTLRPEGTAAMVRYLEHGMKVWPQPVRLWMAGPMFRAERPQKGRYRQFHQVNYEALGSENPILDAEAVLYECLKELGLRRLKVKLSS......................................................................... 164
4 -33.300d3a74a2 d.104.1.1 (A:146-492) Lysyl-tRNA synthetase (LysRS) {Geobacillus stearothermophilus [TaxId: 1422]}  ali model 3D-neighbors follow..  16  1.............................................KYHGLKDIEQRYRQRYLDLIMNPESKKTRSLIIQSMRRYLDSHGYLEVETPMMHAV-----AGGAAARPFITHHNALDMTLYMRIAIELHLKRLI------VGGLEKVYEIGRVFRNEGISTRHNPEFTMLELYEAYADF--RDIMKLTENLIAHI-ATEVLGTTKIQYGEHLVDLTPEWRRLH----MVDAIKEYVGVDFWRQMSDEEARELAK......................... 200
5 -32.700d1z7ma1 d.104.1.1 (A:6-323) ATP phosphoribosyltransferase regulatory subunit HisZ {Lactococcus lactis [TaxId: 1358]}  ali model 3D-neighbors follow..  12  5...........................................................EESAEMTLNQVKS-LRQIEGRLRKLFSLKNYQEVMPPSFEYTQLYTALESNGKEKMFQFIKHEGQSITLRYDFTLPLVRLYSQIKD--STSARYSYFGKIFRKEKRHKGRSTENYQIGIELFGESADKSELESLALQVIEQLGLNKTVFEIGSAKFFQRLCQLADGSTELLTELLLKKDLSGLNAFIEKNNFSKELRGLLKEIFITNELSRL.............. 219
6 -31.800d1l0wa3 d.104.1.1 (A:105-294,A:415-580) Aspartyl-tRNA synthetase (AspRS) {Thermus thermophilus, AspRS-1 [TaxId: 274]}  ali model 3D-neighbors follow..  15  4........................................FPVDAGWRGEEEKEASEELR---DLRRRRMQELRHRVIKAIWDFLDREGFVQVETPFLTKS-----TPEGARDFLVPYRHEPGLFYALPQSPQLFKQMLM------VAGLDRYFQIARCFRDEDLRADRQPDFTQLDLEMSFVEV--EDVLELNERLMAHVFREALLEKDPGRVRALAYDLVLNGVEVGGGSILQARVFRLLGIGEPHGGIAWGLDRLLALMTGSPSIREV.............. 322
7 -27.700d1usya_ d.104.1.1 (A:) ATP phosphoribosyltransferase regulatory subunit HisZ {Thermotoga maritima [TaxId: 2336]}  ali model 3D-neighbors follow..  16  6..........................................................................FEKVFSFYSKATKKGFSPFFVPALEKAEEPA---------GNFFLDRKGNLFSIREDFTKTVLNHRKRYSP--DSQIKVWYADFVYRYSG---SDLVAEYQLGLEKVPRNSLDDSLEEIIVESASEFFEGPVIVEIGHTGVYEDL.................................................................. 138
8 -25.400d3p8ta_ d.104.1.1 (A:) automated matches {Pyrococcus abyssi [TaxId: 29292]}  ali model 3D-neighbors follow..  22  13....................................................................KAIDIQTKILDYMTKFFTDRGFKWLLPIMLSPITDPLWPDPAGEGIRPAEVDVYGVRMRLTHSMILHKQLAIAMGLE------KIFVLSPNIRLESRRKRHSYEFTQLDFEIEGAK--MKDVMRLIEELIYGL--EFYDREENGVWKNYDLILPYGYGEVSSGGEREWEYEKRAGKLKPSAGAGIGVERLVRFIVGAKHIAEV.............. 281
9 -25.300d4j15a2 d.104.1.0 (A:153-495) automated matches {Human (Homo sapiens) [TaxId: 9606]}  ali model 3D-neighbors follow..  17  3...............................QLDDAVRPEAEGEEEGRATVNQDTRLDNRVIDLRTSTAVFRLQSGICHLFRETLINKGFVEIQTPKIISAA-----SEGGANVFTVSYF--KNNAYLAQSPQLYKQMCI------CADFEKVFSIGPVFRAEDSNTRHLTEFVGLDIEMAFNY-HYHEVMEEIADTMVQIGVEYTMPDPRNPKQSNSYDMFMRGEEILSGAQRIHDPQLHHGIDLPHAGGGIGLERVTMLFLGLHNVRQT.............. 337
10 -24.100d3nema2 d.104.1.0 (A:103-316,A:317-438) automated matches {Thermococcus kodakarensis [TaxId: 311400]}  ali model 3D-neighbors follow..  20  16...................................................DTRLDNRFMDLRRPEVMAIFKIRSSVFKAVRDFFHENGFIEIHTPKIIATA-----TEGGTELFPMKYF--EEDAFLAQSPQLYKQIMM------ASGLDRVYEIAPIFRAEEHNTTHLNEAWSIDSEMAFIE-DEEEVMSFLERLVAHA---YIMKYDNKPEICRAFDLEYRGVEISSGGQREHRHDKEKGLNPPHGGFGLGAERLIKQMLDLPNIREV.............. 325
11 -22.100d1x54a2 d.104.1.0 (A:105-434) automated matches {Pyrococcus horikoshii [TaxId: 53953]}  ali model 3D-neighbors follow..  20  12...................................................ELLLDYRHLHIRTPKASAIMKVKETLIMAAREWLLKDGWHEVFPPILVTGA------VEGGATLFKLKY-FDKYAYLSQSAQLYLEAAIFGLE-------KVWSLTPSFRAEKSRTRHLTEFWHLELEAAWMD--LWDIMKVEEELVSYMAIDILQSKGVNVEWGDDLGADEERVEIIGGSQREDDYDLEEGMDPPHSGFGLGVERLVAWVLKLDHIRWA.............. 318
12 -18.300d1jjcb5 d.104.1.1 (B:475-681) Phenyl-tRNA synthetase (PheRS) beta subunit, PheT, central domain {Thermus thermophilus [TaxId: 274]}  ali model 3D-neighbors follow..  19  18..........................................................................YRKEQRLREVLSGLGFQEVYTYSFMDPEDARRFRLDPPRLLLLNPLAPEKAA-LRTHLFPGLVRVLKNLDLDRPERALLFEVGRVFRER--------EETHLAGLLFGELSGYFLLKGYLEALFARLGLAFRVEAQAFPFLGVSGRVLVEGEEVGFLGALHPEIAQELELP-PVHLFELRLPLPDK......................... 206
13 -18.300d1hc7a2 d.104.1.1 (A:5-276) Prolyl-tRNA synthetase (ProRS) {Thermus thermophilus [TaxId: 274]}  ali model 3D-neighbors follow..  12  34................................................................VVRPYGYAIWENIQQVLDRMFKETGHQNAYFPLFIPMSFLRKEAEELAVVTHAGGEELEEPLAVRPTSETVIGYMWSKWIRSWRDPQLLNQWGNVVRWEMRTRPRTSEFLWQEGHTAHATREEAEMLSIYARLAREYAAIPVIEGLKTEKEKEALMKDGKALQAGTSHYLGENFARAFDIKFQTTSWGLSWRFIGAIIMTHGD.................. 271
14 -18.200d12asa_ d.104.1.1 (A:) Asparagine synthetase {Escherichia coli [TaxId: 562]}  ali model 3D-neighbors follow..  15  4....................................................................AKQRQISFVKSHFSRQLEERGLIEVQAPILSRVGTQDNLSGAEKAVQVKVKALPDAQFEV--VHSLAKWKRQTLGQHDFSAGEGLYTHMKALRPDRLSPLHSVYVDQWDWERVMGDG--ERQFSTLKSTVEAI-IHFVHSQELLSRYPDLNPVLEDAFELSSMGVDADTLKHQLALTPQTIGGGIGQSRLTMLLLQLPHIGQVQAG........... 313
15 -13.900d1seta2 d.104.1.1 (A:111-421) Seryl-tRNA synthetase (SerRS) {Thermus thermophilus, strain hb27 [TaxId: 274]}  ali model 3D-neighbors follow..  13  50................................................................ALKGDLALYELALLRFAMDFMARRGFLPMTLPSYAREKAFLGTGHFPAYRDQVWAIAETDLYLTGTAEVVLNALHSGEILPYEALPLRYAGYAPAFRSEAGSFGRVHQFHKVEQYVLASDRAFQELLENAEEILRLLELPYRLVEVATGDMGPGLPSEGRYRETHSCSALLDWQARRANLRYTLNNTALATPRILAMLLENHQLQD............... 289
16 -13.800d4hwsa1 d.104.1.1 (A:242-532) automated matches {Escherichia coli K-12 [TaxId: 83333]}  ali model 3D-neighbors follow..  18  24................................................................FWHNDGWTIFRELEVFVRSKLKEYQYQEVKGPFMMDRVLWEKTG-DNYKDAMFTTSSENREYCIKPMNCPGHVQIFNQGLKSYRDPLRMAEFGSCHRNEPSGSMRVRGFTQDDAHIFCTEEQIRDCIRLVYDMYSTFGFEKIVVKLST......................................................................... 181
17 -10.800d1j5wa_ d.104.1.1 (A:) Glycyl-tRNA synthetase (GlyRS) alpha chain {Thermotoga maritima [TaxId: 2336]}  ali model 3D-neighbors follow..  12  4..........................................................................QDVIMKLNDFWASKGCLLEQPYDME--------------------------------VGAGTFHPATFFGSLRKGPWKVAYVQPSRRPTDGRY-GENPNRLQRYFQYQVKPSPENSQELYLESLEYLGIEDNWESPTLGAWGVGWEVWLDGMEITQFTYF--QQIGGISLKDIPLEITYGLERIAMYLQGVDNVYEV.............. 177

FFAS is supported by the NIH grant R01-GM087218-01
1 2 6 4 9 8   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Friedberg I, Godzik A. Fragnostic: walking through protein structure space. Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W249-51.