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Query: 3a5y_A mol:protein length:345 Putative lysyl-tRNA synthetase, from PDB1018

Results of FFAS03 search in SCOP207
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MGSSSSGLVPRGSHMSETASWQPSASIPNLLKRAAIMAEIRRFFADRGVLEVETPCMSQATVTDIHLVPFETRFVGPGHSQGMNLWLMTSPEYHMKRLLVAGCGPVFQLCRSFRNEEMGRYHNPEFTMLEWYRPHYDMYRLMNEVDDLLQQVLDCPAAESLSYQQAFLRYLEIDPLSADKTQLREVAAKLDLSNVADTEEDRDTLLQLLFTFGVEPNIGKEKPTFVYHFPASQASLAQISTEDHRVAERFEVYYKGIELANGFHELTDAREQQQRFEQDNRKRAARGLPQHPIDQNLIEALKVGMPDCSGVALGVDRLVMLALGAETLAEVIAFSVDRALast
1 -109.000d3a74a2 d.104.1.1 (A:146-492) Lysyl-tRNA synthetase (LysRS) {Geobacillus stearothermophilus [TaxId: 1422]}  ali model 3D-neighbors follow..  30  3HGLKDIEQRYRQRYLDLIMN---PESKKTFITRSLIIQSMRRYLDSHGYLEVETPMMHA-VAGGAAARPFITH----HNALDMTLYMRIAIELHLKRLIVGGLEKVYEIGRVFRNEGISTRHNPEFTMLELYEAYADFRDIMKLTENLIAHIATTPEWRRLHMVDAIKEYVGVDFWRQMSDEEARELAK-EHGVEVAPHMTFGHIVNEFFEQKVEDKL--IQPTFIYGHPVEISPLAKKNPDDPRFTDRFELFIVGREHANAFTELNDPIDQRQRFEEQLKEREQGNDEAHEMDEDFLEALEYGMPPTGGLGIGVDRLVMLLTNSPSIRDVLLFPQMRH 347
2 -89.000d1l0wa3 d.104.1.1 (A:105-294,A:415-580) Aspartyl-tRNA synthetase (AspRS) {Thermus thermophilus, AspRS-1 [TaxId: 274]}  ali model 3D-neighbors follow..  23  18...ASEELRLKYRYLDL----RRRRMQENLRLRHRVIKAIWDFLDREGFVQVETPFLTKS-TPEGARDFLVPY----RHEPGLFYALPQSPQLFKQMLMVAGLDRYFQIARCFRDEDLRADRQPDFTQLDLEMSFVEVEDVLELNERLMAHVFREAPFPRLSYEEAMERYGSDKPDLRXREGF-------------RFLWVVDFPLLEWDEEEEAWTY--MHHPFTSPHPEDLPLLEK--DPGRVRALAYDLVLNGVEVGGGSIRIHDPRLQARVFRLL----GIGEEEQREKFGFFLEALEYGAPPHGGIAWGLDRLLALMTGSPSIREVIAFPKNKE 330
3 -73.000d4j15a2 d.104.1.0 (A:153-495) automated matches {Human (Homo sapiens) [TaxId: 9606]}  ali model 3D-neighbors follow..  16  20.ATVNQDTRLDNRVIDL----RTSTSQAVFRLQSGICHLFRETLINKGFVEIQTPKIISA-ASEGGANVFTVSY------FKNNAYLAQSPQLYKQMCICADFEKVFSIGPVFRAEDSNTRHLTEFVGLDIEMAFNYYHEVMEEIADTMVQIFKGLQERFQTEIQTVNKQFPCEPFKFLEPTLRLEYCEAEAGVEMGDEDDLSTPNEKLLGHLVKEKYD-TDFYILDKYPLAVRPFTMPDPRNPKQSNSYDMFMRGEEILSGAQRIHDPQLLTERALHHGIDLEK--------IKAYIDSFRFGAPPHAGGGIGLERVTMLFLGLHNVRQTSMFP.... 341
4 -69.500d3nema2 d.104.1.0 (A:103-316,A:317-438) automated matches {Thermococcus kodakarensis [TaxId: 311400]}  ali model 3D-neighbors follow..  17  13...AELDTRLDNRFMDL----RRPEVMAIFKIRSSVFKAVRDFFHENGFIEIHTPKIIAT-ATEGGTELFPMKY------FEEDAFLAQSPQLYKQIMMASGLDRVYEIAPIFRAEEHNTRHLNEAWSIDSEMAFIDEEEVMSFLERLVAHAINYVREHNAKELDILNFELKLPFPRVSYDKALEILGDLGKEIPWGEDIDTEGERLLGKYXMMENEN--APLYFLYQYPSEAKPFIMKYDNKPEICRAFDLEYRGVEISSGGQREHRHDILVEQIKEKGLNPES--------FEFYLKAFRYGMPPHGGFGLGAERLIKQMLDLPNIREVILFPRDRR 333
5 -63.600d1x54a2 d.104.1.0 (A:105-434) automated matches {Pyrococcus horikoshii [TaxId: 53953]}  ali model 3D-neighbors follow..  16  10....SPELLLDYRHLHI----RTPKASAIMKVKETLIMAAREWLLKDGWHEVFPPILVTG-AVEGGATLFKLKY------FDKYAYLSQSAQLYLEAAI-FGLEKVWSLTPSFRAEKSRTRHLTEFWHLELEAAWMDLWDIMKVEEELVSYMVQRTLELRKKEIEMFRDDLTTLKNTEPPFPRISYDEAIDILQSKGVNVEWGDDLGADEERVLTEEFD--RPFFVYGYPKHIKAFMKEDPNDPRKVLASDML-----APEGYGEIIGGSQREDDYDKLLNRILEEGMDPKDY-EWYLDLRRYGSVPHSGFGLGVERLVAWVLKLDHIRWAALFPRTPA 326
6 -49.200d3p8ta_ d.104.1.1 (A:) automated matches {Pyrococcus abyssi [TaxId: 29292]}  ali model 3D-neighbors follow..  17  2............NAVEI----ISRDIYKAIDIQTKILDYMTKFFTDRGFKWLLPIMLSPITDPLWPDPAGEGIRPAEVDVYGVRMRLTHSMILHKQLAIAMGLEKIFVLSPNIRLESRDGRHSYEFTQLDFEIEGAKMKDVMRLIEELIYGLFRKAEEWTGREFPRARHFKVYDYKDILE----------------------------EFGSDEKASMEMEEPFWIVNIPREFYDR---EENGVWKNYDLILPYGYGEVSSGGEREWEYEKIVAKIRAAGLKEDS---------RPYLEIARAGLKPSAGAGIGVERLVRFIVGAKHIAEVQPFP.... 285
7 -44.700d12asa_ d.104.1.1 (A:) Asparagine synthetase {Escherichia coli [TaxId: 562]}  ali model 3D-neighbors follow..  12  4.......................AKQRQISFVKSHFSRQLEERL---GLIEVQAPILSRVGTQDNLSGAEKAVQVKVKALPDAQFEVVHSLAKWKRQTLFSAGEGLYTHMKALRPDELSPLHSVYVDQWDWERVMGDGERQFSTLKSTVEAIWAGIKATEAAVSEEFGLAPFLQIHFVHSQELLSRYPDLDAKGRERAKDLGAVFLVGIGGKLSDGHRHDVRAPDYDDWSTPSELGHAGLNGD--ILVWNPVLEDAFELSSMGIRVDADTLKHQLALTGDEDRLE---------EWHQALLRGEMPQTIGGGIGQSRLTMLLLQLPHIGQVQAWP.... 316
8 -14.000d1wu7a2 d.104.1.1 (A:3-329) Histidyl-tRNA synthetase (HisRS) {Thermoplasma acidophilum [TaxId: 2303]}  ali model 3D-neighbors follow..  16...........................EDMDVEKFIFKTAEEAAEAFGFRRIDFPSLEYLLYRIKSGEELLQQTYSFVDKGGREVTLIPEATPSTVRMVTSRKDRWYSFPKVWRYEEPQAGRYREHYQFNA---------------DIFGSDSPEADAEVIALASSILDRLGLQDIYEIRINSRKIMEEIIGGMTSSDPFSVFSIIDRYHKISREEFV---------------DQLRSAGIGEDGVSMIADLCSGTRGIDEMARITGKSSEEIARMAAVEDLLASYGVKNVRYDFSIVRGLSY---PAVGFGMGDAVISLLLKREN............. 323
9 -13.500d1h4vb2 d.104.1.1 (B:2-325) Histidyl-tRNA synthetase (HisRS) {Thermus thermophilus [TaxId: 274]}  ali model 3D-neighbors follow..  15  14...........................KELRMHQRIVATARKVLEAAGALELVTPIFEET-GVGAATDIVRKEMFTFQDRGGRSLTLRPEGTAAMVRAYLEH--RLWMAGPMFRAERPQKGRYRQFHQVNYEALGSENPILDAEAVVLLYECLKELGLRRARYNAYLREVLSPHREALS-EDSKERLEENPMRILDSKSERDQALLKELGVRPMLDFLGEEARAHLKEVERHLERLSVPYELEPALVRGLDYYVRTAEVHHEEIGAQSALGGGGRY------------------DGLSELLGGPRVPGVGFAFGVERVALALEAEG............. 319
10 -11.900d1jjca_ d.104.1.1 (A:) Phenyl-tRNA synthetase (PheRS) alpha subunit, PheS {Thermus thermophilus [TaxId: 274]}  ali model 3D-neighbors follow..  15  20.................................TLMERELVEIFRALGYQAVEGPEVESE-----NFDALNIPEHHPARDMWDTFWLTLGEEVEGRLLLRTHTSRIVVPGRVFRFEQTDATHEAVFHQLEGLVVGEGIA--MAHLKGAIYELAQALFGPDSKVR---------------------------------------------------------QPVY---FP--VEPGAQFAVWWPEGGKWLELGGAGM----VHPKVFQAVDAYRERLGLPPAYRG---------------------TGFAFGLGVERLAMLRYGIPDIRYF........ 251
11 -10.800d1z7ma1 d.104.1.1 (A:6-323) ATP phosphoribosyltransferase regulatory subunit HisZ {Lactococcus lactis [TaxId: 1358]}  ali model 3D-neighbors follow..  11  13...........................NQVKSLRQIEGRLRKLFSLKNYQEVMPPSFEYTALESNGKTFNQEKMFQFIKHEGQSITLRYDFTLPLVRLYSQIKDRYSYFGKIFRKEKRHKGRSTENYQIELFGESADKSEILSLALQVIEQLGLNKTVFEIGSAKFFQRLCQLDGSTELLTELLLKKDLSGLNAFIEKNNFSKELRGLLKEIFITNELSRLENLVTNTKDDVLISMIKPIIIDLGMVPKMD-YYTDLMFKAYSSAANQPILSGGRY------------------DQLLSNFQEEAF-AIGFCCHMDTILKALERQE............. 317
12 -10.300d1hc7a2 d.104.1.1 (A:5-276) Prolyl-tRNA synthetase (ProRS) {Thermus thermophilus [TaxId: 274]}  ali model 3D-neighbors follow..  13  2.GLTPQSQDFSEWYLEVIQKAELADYGPVYAIWENIQQVLDRMFKETGHQNAYFPLFIPMSF-EGFSPELAVVTHAGGEELEEPLAVRPTSETVIGYMWSKWIRSLNQWGNVVRWETRPFLRTSEFLWQEGHTAHATREEAEEEVRRMLSIYARLAREYAAIPVIEGLKTEKEKFAGAVYTTTIEALMKDGKALQAGTSHYLGENFARAFDIKFQDRDLQVKYVHTTSWGLSWRFIGAI.................................................................................................... 265

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Berman HM, Burley SK, Chiu W, Sali A, Adzhubei A, Bourne PE, Bryant SH,Dunbrack RL Jr, Fidelis K, Frank J, Godzik A, Henrick K, Joachimiak A, HeymannB, Jones D, Markley JL, Moult J, Montelione GT, Orengo C, Rossmann MG, Rost B,Saibil H, Schwede T, Standley DM, Westbrook JD. Outcome of a workshop on archiving structural models of biological macromolecules. Structure. 2006 Aug;14(8):1211-7.