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Query: 1h4q_A mol:protein length:477 PROLYL-TRNA SYNTHETASE, from PDB1018

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MAKEKGLTPQSQDFSEWYLEVIQKAELADYGPVRGTIVVRPYGYAIWENIQQVLDRMFKETGHQNAYFPLFIPMSFLRKEAEHVEGFSPELAVVTHAGGEELEEPLAVRPTSETVIGYMWSKWIRSWRDLPQLLNQWGNVVRWEMRTRPFLRTSEFLWQEGHTAHATREEAEEEVRRMLSIYARLAREYAAIPVIEGLKTEKEKFAGAVYTTTIEALMKDGKALQAGTSHYLGENFARAFDIKFQDRDLQVKYVHTTSWGLSWRFIGAIIMTHGDDRGLVLPPRLAPIQVVIVPIYKDESRERVLEAAQGLRQALLAQGLRVHLDDRDQHTPGYKFHEWELKGVPFRVELGPKDLEGGQAVLASRLGGKETLPLAALPEALPGKLDAFHEELYRRALAFREDHTRKVDTYEAFKEAVQEGFALAFHCGDKACERLIQEETTATTRCVPFEAEPEEGFCVRCGRPSAYGKRVVFAKAYLast
1 -128.000[J] KOG4163 Prolyl-tRNA synthetase  ali follow..  43  181DAKLIGITVDKLDFPGWYQQILTKGEMLDYYDVSGCYILRPPSYAIWENIQKWFDDKIKAIGVQNAYFPMFVSSRVLEKEKDHVEGFAPEVAWVTRAGSSELEEPIAIRPTSETVMYPYYAKWVQSYRDLPLKLNQWNSVVRWEFKPQPFLRTREFLWQEGHTAHLTAKDAEEEVLQILDFYAGVYEELLAVPVVKGRKTEKEKFAGGDFTTTCEGIPQTGRGIQGATSHHLGQNFSKMFNLSVENPLGSDHFAYQNSWGLSTRVIGVMVMIHSDNKGLVIPPRVSQFQSVVIPVGITKKRKHIHETARSVESRLKKVGIRAFGDYNDNYTPGWKFSQYELKGIPIRIELGPKDIEKNQVVVVRRNDSKKVVSFDELEARIPEILEEMQGDLFKKAKELFDTHRVIVNEWSGFVPALNKKVILAPWCGVMECEEDIKESSGAKSLCIPFDQPVEGQKCIKCERIAV--NYCMFGRSY 688
2 -79.600[J] KOG2324 Prolyl-tRNA synthetase  ali follow..  20  2LQHLRNRASIEYNVPESANQLLIDMGFIQ-PSMPGIFQYLPLGLRVQNKICDLLHISMRSLGASAISLAHLSSKE-IWEKSGRWQKTGSELFRLH----DRNDREMCLAPTHEEDVTRTMATIIDSQKQLPIRVYQIGRKFRDELRPRGLLRGREFMMKDLYTFDIDKASAMKTYEDVLQAYHTFFKEVGLPFVMVKAATGNIGGNLSHECPNCNDQLTSTTAIEVGHAFYLGKIYSSKFNATV-EVKNKQEVLHMGCYGIVSRLIAAVAHVTKDAKGLVWPSSIAPWKVLVVPT-----SDNHIQSAETVYDATANVV-NVLLEDRQNRAFGYKMRDAELIGYPFVIVVGSRFQEEGICEIIVRSSGERKLDKDSLHQVLLGNF............................................................................................ 424
3 -76.400[J] COG0442 Prolyl-tRNA synthetase  ali follow..  22  3TSQYLLSTQKEADAEVISHQLMLRAGMI-RKLASGLYTWLPTGVRVLKKVENIVREEMNNAGAIEVSMPVVQPAD-LWQESGRWEQYGPELLRFVDRG----ERPFVLGPTHEEVITDLIRGEINSYKQLPLNFFQIQTKFRDEVRPRGVMRAREFLMKDAYSFHTTQESLQETYDAMYTAYSKIFSRMDLNFRAVLADTGSIGGSASHESPDGKGTLQIKRGIEVGHIFQLGTKYSEVMKATVQGEDGRNQVMTMGCYGIVSRVVAAAIEQNHDDRGIIWPDAIAPFQVAILPMNMH-KSFRVKELAEELYTTLRSHGIDVILDDR-KERPGVMFADMELIGVPHNIVIGDRNLDSEEVEYKNRRVGEKQIKTSEIVEFLLSQIKR.......................................................................................... 572
4 -61.700[J] KOG1637 Threonyl-tRNA synthetase  ali follow..  17  263LQRVYGISFPDPKQLKEWEKLQEEAAKRDHRKIPGSCFFQPRGAHIYNTLMGFIKAEYRKRGFQEVISPNIYNAK-LWMTSGHWQHYAENMFSF-----EAEKEKFALKPMNCPGHCLIFDNRNRSWRELPLRMADFGVLHRNELSLTGLTRVRRFQQDDAHIFC-APEQIKSEMKGCLEFLKYVYTIFGFSFQLFGMPWKENPGDGAFYGPKIDITIMDALKRAQCATIQLDFQLPIRFNLSYIADDGEKKIIHRAILGSVERMIAILT----ENFAGKWPFWLSPRQVMVVPVG-----PAYDQYAQSVRDQLHDAGFMSEADCDAGDTMNKKIRNAQLAQFNFILVVGDKERSSNTVNVRTRDNKVGEVSVAELITKLQKIRDEFIANEDS................................................................................... 689
5 -60.500[J] COG0441 Threonyl-tRNA synthetase  ali follow..  19  215LQRIYGTAWADKKALNAYLQRLEEAAKRDHRKIPGMVFWHNDGWTIFRELEVFVRSKLKEYQYQEVKGPFMMDRV-LWEKTGHWDNYKDAMFTT-----SSENREYCIKPMNCPGHVQIFNQGLKSYRDLPLRMAEFGSCHRNEPSLHGLMRVRGFTQDDAHIFC-TEEQIRDEVNGCIRLVYDMYSTFGFALEENNIPFEYQLGEGAFYGPKIEFTLYDCLDRAQCGTVQLDFSLPSRLSASYVGEDNERKMIHRAILGSMERFIGILT----EEFAGFFPTWLAPVQVVIMNIT-----DSQSEYVNELTQKLSNAGIRVKADLR-NEKIGFKIREHTLRRVPYMLVCGDKEVESGKIAVRTRRGKDGSMDVNEVIEKLQQEIRSRSLKQLEE.................................................................................. 642
6 -44.700[J] COG0423 Glycyl-tRNA synthetase (class II)  ali follow..  14  1MTE---VSKAAAFDRTQFEELMKKRFFF-YGGISGLYDYGPPGSALQSNLVDIWRKHFIEESMLEVDCSMLTPHE-VLKTSGHVDKFADNLMFETQIGPSGGLKGYLRPETAQGQFLNFSRLLEFNNGKVPFASAMVGKAFRNEISPRGLLRVREFLMAEVEHFVDPKNKEHDRFDEVSHMPLRLLPRGVQL-AKAVEEAMISWPESEKVEKSAQLVAEGKIIVNVNGVEHTVESDLVTIEKRKHTEHIRTYTPNVIEPSFLGRILYVLMEHDVNRGVLSFPASIAPIKALIVPLS---RNAEFAPFVKKLSAKLRNLGISNKIDDSNA-NIGRRYARNDELGTPFGLTVDFETLQNETITLRERDSTKQVGSQDEVIAALVSMVEG------KSSFEDALAKFGEFKSTQE................................................................. 652
7 -33.500[J] KOG2298 Glycyl-tRNA synthetase and related class II tRNA synthetase  ali follow..  16  60.......PKDDIVDRAKMEDTLKRRFFY-YGGVSGLYDFGPVGCALKNNIIQTWRQHFQEEQILEIDCTMLTPEP-VLKTSGHVDKFADFMVKDVKNGEGGNMPGYLRPETAQGIFLNFKRLLEFNQGKLPFAAAQIGNSFRNEISPRGLIRVREFTMAEIEHFVDPSEKDHPKFQNVADLHLYLYTKVGISPDKLRFRQHMENEMAHYACDCWDAESKTSYGIETEGKTFQLTKDMINVKRFQKTLYVEEVVPNVISFGLGRIMYTVFEHTFHVREGFSFPAVVAPFKCSVLPLS---QNQEFMPFVKELSEALTRHGVSHKVDDSSG-SIGRRYARTDEIGVAFGVTIDFDTVNKTTATLRDRDSMRQIAEISELPSIVQDLANG--ADVEARYPLFEGQETGKKETIEE................................................................. 685
8 -22.800[J] COG0124 Histidyl-tRNA synthetase  ali follow..  14  1...........................MAIQIPRGTQDILPGDVETWQWIEQKAYDLCRRYNYQEIRVPMFEHTELFLRGVGD-DIVQKEMYTFEDRG----GRSLTLRPEGTASVTRAYSNKLYGQANQPTKLFYIGPMFRYERPQSG--RMRQFVQFGVEALGSADPAIDAE---VLALVMRFYEELGLKNLKLVINSLGDTDSRLAHREALVNHFKPRIHVDATLVRGLDYYNHTAFEVMVDGEGGRYNGLVEEIGGPETPGIGFALSIER-EAQQAKPAHNQAIDCYVVTLG-----EAAKDKGVELVYQLRNAGISAEKD--LDRKMKGQLKAADRLHAKWTVILGEDELAVGKVNVKNMETGEQDVALTDLVSHMKQQVEGGNES...................................................................................... 428
9 -21.600[J] KOG1936 Histidyl-tRNA synthetase  ali follow..  14  50......................QEKPNFIIKTPKGTRDLSPQHMVVREKILDLVISCFKRHGAKGMDTPAFELKETLTEKYGE----SGLMYDLKDQG----GELLSLRY-----LTVPFARYLAMNKVKKMKRYHVGKVWRRESPTIVQGRYREFCQCDFDIAGQFDPMIPDA--ECLKIMCEILSGLQLGDFLIKVNDRSQNKQALEGLGDLKLLFEYLTLFGIADKISFDLSLARGLDTPTQAGEEPLNVGSVAAGGRYDGLVGMFDPKGHKVPCVGLSIGVTETQVFVATP-----QKNFLQERLKLIAELWDSGIKAEMLYKNNPKLLTQLHYCESTGIPLVVIIGEQELKEGVIKIRSASREEVAIKRENFVAEIQKRLSE.......................................................................................... 505
10 -21.400[J] KOG2509 Seryl-tRNA synthetase  ali follow..  15  170.................HVDLVVMVDGFEGEVVAGSYFLKGVLVFLEQALIQYALRTLGSRGYIPIYTPFFMRKEVM-QEVAQLSQFDEELYKVIGKGSEKSYDEKYLIATSEQPIAALHRDEWLRPEDLPIKYAGLSTCFRQEVDTRGIFRVHQFEKIEQFVYSSPHNKSWEMFEEMITTAEEFYQSLGIPYHIVNIVSG-SLNHAASKKLDLEAWFPGSGA-ELVSCSNCTDYQARRLRIRYGQTKKMMDHMLNATMCATTRTICAILENYQTEKGITVPEKLKEFLQELIPFVKPAPIEQEPSKKQKKQHEGSKKKAAARDVTLENRLQNMEVTDA.......................................................................................................................................... 514
11 -19.400[J] COG0172 Seryl-tRNA synthetase  ali follow..  15  123EVRKWGEVPNFPFEPKAHWDLATALGIVDFEKVTGSAFYKGAGARLERALINFMDLHHDKHGYEEVLPPYLVNRTSM-TGTGQLPKFEEDAFKIR-------EEDYFLIPTAEVPVTNLHRDEILSADQLPIAYTAYSMNFRSEADTRGLIRQHQFNKVELVRF-VAPEDSYDELEKLTGHAEKVLQLLKLPYRVMSMCTA-DLGFTAAKKYDLEVWIPSANT-EISSCSNFEDFQARRANIKFRREAKGKAEFVHTLNGAVGRTVAAILENYQQEDGIVIPEVLRPY............................................................................................................................................................................................. 416
12 -11.200[E] COG3705 ATP phosphoribosyltransferase involved in histidine biosynthesis  ali follow..  11  1..........................MQTWQLPEHIADVLPTNARQLESAREQLLALFRVHGYELVQPPLMEYAHSLLTHID--AGLSLKTILVTD---RLSGRQLGIRADITPQVARIDAHLLSA-NQGINRLCYAGPVLHAQSDGLL--NMREPLQAGAEMYGFADIRGDIELIDLMETVEAQVKAWKLDGMWAKAFSLLPRLYGGELQAVCDAFPDCEIHIDLSELRVDNYHTGLLYAAYAADFHGGRYDGLGGYFGRARPATGFSFDL--RSFIGRLPAIERQPAVLVDAEDAEA--------AHEAVEALREQGQCVVIDYGIGHNVSEELAGRLKKTDGVWQVVKR............................................................................................................................. 383

FFAS is supported by the NIH grant R01-GM087218-01
1 2 7 7 0 6   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Ye Y, Osterman A, Overbeek R, Godzik A. Automatic detection of subsystem/pathway variants in genome analysis. Bioinformatics. 2005 Jun 1;21 Suppl 1:i478-i486.