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Query: 4lns_A mol:protein length:351 Asparagine synthetase a, from PDB1018

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MGDDGYSSYVLLQEQILTVKRSFSEALEKELNLVEVRAPILFRVGDGTQDNLSGFEKAVQVPVKAIPNASFEVVHSLAKWKRRTLANYKFAPGHGLYTHMTALRVDDVLDNIHSVVVDQWDWEMVMKDDQRNLAFLKEVVCKVYAAIRKTELAVCEKYKQKPILPETIQFVHAEHLLLAYPNLTAKEREREIAREYGAVFLIGIGAVLSSGDRHDARAPDYDDWTSPVEASQVVFPRTSKPIPTMNSLSSLKGLNGDILLYNPTLDDSLEVSSMGIRVNAEALRHQISLTGDDSLLKSEWHQQLLNGEFPQTVGGGIGQSRMVMFMLRKKHIGEVQCSVWPEEIRKKHNLLLast
1 -108.000[E] COG2502 Asparagine synthetase A  ali follow..  58  3......KTFILQQQEISFVKNTFTQNLIEQLGIIEVQGPILSQVGNGMQDNLSGIEKAVQVNVKCIPNAVFEVVHSLAKWKRHTLARFNFKEDEGLFVHMKALRPDEDLDPTHSVYVDQWDWEKVIPEGRRNFAYLKETVNSIYRAIRLTELAVEARFDIPSILPKQITFVHSEDLVKRYPDLSSKERENAICKEYGAVFLIGIGGKLSDGKPHDGRAPDYDDWTT-------------------ESENGYKGLNGDILVWNDQLGKAFELSSMGIRVDESALRLQVGLTGDEDHLKMDWHQDLLNGKLPLTIGGGIGQSRLAMLLLRKKHIGEVQSSVWPKEMLEEFSNI 329
2 -69.600[J] COG0017 Aspartyl/asparaginyl-tRNA synthetases  ali follow..  12  113LMDHRHLWLRKKQHAVMKIRNEVIRATYEFFGFTKVDPPILTASAP---------EGTSELFHTKYFDQDAFLSQSGQLYLEAAA-----MAHGKVFSFGPTFRAEKSKTRRHLIEFWMIEGEMAFTNHAESLEIQEQYVTHVVKSVLENCKLELKILERDTS--------KLEKVATPFPRISYDDAIEFLKAEG--------FDDIEWGEDFGAPHETAIANHYDLPVFITNYPTKIKPFYMQPPENEETVLCADLIA-----EGYGEIIGGSERVDDLELLEQRVKEHGLDEEAYSYYLDLRRYGSVPHCGFGLGLERTVAWISGVEHVRETA--PFPRLLNRLYP.. 430
3 -65.200[J] KOG0554 Asparaginyl-tRNA synthetase (mitochondrial)  ali follow..  11  220........RTNTFGAVARVRNTLAYATHKFFGFVWVASPIITASDCEGAGEQFCVTTLIP-WSQDFFGKPAFLTVSGQLNGETYA-----TALSDVYTFGPTFRAENSNTSRHLAEFWMIEPELAFADLDDDMACATAYLQYVVKYVLDNCKEDMEFFDTW--IEKGIIRRLSDVAEKEFLQLGYTDAIEILLKAN-----KKFDFPVKWGLDLQSEHERYEEAFGGRPVIIRDYPKEIKAFYMRENDDGKTVAAMDML-----VPRIGELIGGSQREERLEVLEARLDELKLNKESYWWYLDLRRYGSVPHAGFGLGFERLVQFVTGIDNIRDVI--PFPRTPASAE... 566
4 -64.700[J] KOG0556 Aspartyl-tRNA synthetase  ali follow..  13  239..DNRVLDLRPTNQAIFDIQAGICQAFREFLSFNEIHTPKMSGASS---------EGGSNVFKIQYFKTDGFLSQSPQLYKQMLI----AADRERVFEIGPVFRAEDSNTYRHMTEFTGLDLEMAFNEYHEVMEFIEKLFLYIFKTIREKYAKQVAVVRQQYPSED------FILPDADRIRFHFKDAVKLLKEDEEFHYCEDPEFDDFSTPEERALGQIVREKYHTDFYVIDKYPSSVRPFYTMPDPE-----DPRYSNSYDFFMKGQEIMSGAQRIHDPELLVERMKALGVSPDVLQQYIDAFAIGCPPHAGGGIGLERVVMFYLNLPNIRLAS--SFPRDPKRLLP.. 580
5 -61.500[J] KOG0555 Asparaginyl-tRNA synthetase  ali follow..  13  227..DNRHLVIRENASRILRIRAAATRAMRDHFGYTEVAPPTLVQTQV---------EGGSTLFGLDYYGEPAYLTQSSQLYLETCN-----AALGDVYCISQSYRAEKSRTRRHLSEYQHVEAECAFITFDQLMDRIEALVCDTVDRLLADPVTKSLIEFVNP---------GYKAPARPFKRMPYKEAIEWLQKNDVRN---EMGEKFVYGEDIAEAAERRMTDTIGVPILLNRFPHGIKAFYMPRADDNELTESVDLL-----MPGVGEIVGGSMRIWKEDQLLAAFEKGGLDSKNYYWYMDQRKYGSVPHGGYGLGLERFICWLTDTNHIRDVC--LYPRFVGRCAP.. 545
6 -49.100[J] KOG2411 Aspartyl-tRNA synthetase, mitochondrial  ali follow..  12  1............MQYNLRLRSQMVMKMREYLGFVDIETPTLFKRTPGGAKEF--------LVPSREPGKFCSLPQSPQQFKQLLM----VGGLDRYFQVARCYR-DEGSRPDRQPEFTQIDIEMSFVDQTGIQSLIEGLLQYSWPNDKDPVVVPFPTMTFAEVLPDTRFGMKIIDISDVFRNTEIGELIRLMETQEEDVVLLTAGEHNKACSLLGKLRLECADWVVDFPLFLPKEESPRELESAHHPFTAPHPSDIHLLYHYDLVLNGNEIGGGSIRIHNAELQRYIATLLKEDVKMLSHLLQALDYGAPPHGGIALGLDRLICLVTGSPSIRDVIA--FPKSFRGHDLMS 433
7 -47.300[J] COG0173 Aspartyl-tRNA synthetase  ali follow..  13  125...NRVIDLRRVMQRNLRLRYQVAMGVRRYLGFIDIETPMLTRSTPEGARDYL-------VPSRVHPGEFFALPQSPQLFKQLLM----VAGFDRYYQITKCFR-DEDLRADRQPEFTQIDLETSFLNEDEIMDITEGMAKQVFKDALNVDLGDFPRMPYSEAMPDMRINLKFTELTDLMKTEEFKVFRGAADMKGGRVVALRVPNGAEFSRKEIDEEYDEEADRYVAVHHPFTAPKEGHEDLMVSDPANCLARAYDMVL------NGWEIGGGSIRIHRADVQEKLKISPEEQQEKFGFLLDNLKFGAPPHGGLAFGLDRLVTLMTGAESIRDVIA--FPKTQRAQCLLT 574
8 -45.900[J] COG2269 Truncated, possibly inactive, lysyl-tRNA synthetase (class II)  ali follow..  14  33.PTASISQLKQRATLLRQIREFFAER-----NVLEVETPAMSHAT--VTDIHLHTFKTEFVGPGYAKGSALHLMTSPEFHMKRLL----AAGSGCIYQLGKAFR-NEENGRYHNPEFTMLEWYRIGFDHHALMDEMDALLQLVLRCGSAERMTYQEAF---------------LNVLGVCPLEEEMRELKQVAATLGLSDIAEPEEDRDTLLQLLFSIGIEPKIGQITPAFVYDFPASQAALAKINPADPRVADRFEVYF------KGIELANGFHELDNPAEQLARFKADNAKRLEMG-LIAALEAGLPECAGVALGIDRLIMLALGEDHIDKVT--AFP.......... 345
9 -39.200[J] COG1190 Lysyl-tRNA synthetase (class II)  ali follow..  12  169...QRYLDLIDESRHTFKVRSQVMSGIRSFMGFMEVETPMMQVIPGGASARPFVTH-------HNALDIDMYLRIAPELY----LKRLVVGGFERVFEINRNFR-NEGVSPRHNPEFTMMELYMAYADYKDLIVLTEELFRTLTETILGSSVVQYGEQTFDFGKPTMKEAICKYRPETNVADLDDMDKAVAIAESLGI----KVEKSWGLGRIQCEIFEETAESHLIQPTFITEYPAEVSPLARRNDDNPFITDRFEFFIGGREIGNGFELNDAEDQAQRFADQVSAKEAGDDEAMFYD-YITALEHGLPPTAGLGIGIDRMVMLFTNSHTIRDVI--LFP.......... 499
10 -38.100[J] KOG1885 Lysyl-tRNA synthetase (class II)  ali follow..  10  229...QRYLDLIDFVRQKFIIRSKIITYIRSFLGFLEIETPMMNIIPGGAVAKPFITY-------HNELDMNLYMRIAPELY----HKMLVVGGIDRVYEIGRQFR-NEGIDLTHNPEFTTCEFYMAYADYHDLMEITEKMVSGMVKHITGSYKVTYHPDGPEGQ--------YDVDFTPPFRRINMVEELEKALDDICVAKAVECPPPRTTARLLDKLVGEFLEVTCINPTFICDHPQIMSPLAKWHRSKEGLTERFELFVMKKEICNAYELNDPMRQRQLFEEQAKAKAAGDDEAMFID-FCTALEYGLPPTAGWGMGIDRVAMFLTDSNNIKEVL--LFP.......... 571
11 -11.800[J] COG0016 Phenylalanyl-tRNA synthetase alpha subunit  ali follow..  11  106...........GAHPLTATITEVEDLFIG-LGFSVAEGPQIETDYYNFEALNLPKDHPADMQDSFYFTDELLLRTQTSPVQARTMEKYKGKGPIKIICPGKVFRRDD-DDATHSHQFMQIE---LYVDHGVRMSDLKGVLQAFAKSFFGEERSIRLR-------PSFFPFTEPSVEVDVSCGICHGDGCRVCKQTG------------------------------------------------------------------------IEILGAGM------VHPRVLEMSGFNPNEYSGF------------AFGMGVERLSMLKYGIDDIRHFYTN-FLAQFKRV.... 344
12 -9.680[J] KOG1936 Histidyl-tRNA synthetase  ali follow..  12  61...KGTRDLSPQHMVVREKILDLVISCFKRHGAKGMDTPAFELKETLTEK--YGEDSGLMYDLKDQGGELLSLRYDLTVPFARYLAMNKVKKM-KRYHVGKVWRRESPTIVQRYREFCQCDFDIAMIPDAECLKIMCEILSGL--LIKVNDRRIVDGMFAVCGVPES-KFRAICSSIDKLDKMAWKDVRHEMVVKKGLA--PEVADRIGDYVQCHGGVSLVEQMFQDPRLSQNKQALEGLGDLKLLFEYLTLFGIADKISFDLSLARGLDYYTGVI----EAVLLQTPTQAGEEPLNVGSVAAGGRYD--PCVGLSIGVERIFYIVEQRMKTKG................. 402
13 -9.120[J] COG0124 Histidyl-tRNA synthetase  ali follow..  7...RGTQDILPGDVETWQWIEQKAYDLCRRYNYQEIRVPMFEHTELRGVGDTTDIVQKEMYTFEDRGGRSLTLRPEGTASVTRAYVSNKLYG--KLFYIGPMFRYERPQSGRMR-QFVQFGVEALGSADPAIDAEVLALVMRFYEELGLKNLKLVINSLGDTDSRLAHREALVNHFKPRIHEFCNDCQDRLEKNPLRILDCKKDRDHELMGTAPSIHDYLSTESKAYFEKVQSYLTALNIPFVVDAT-DYYNHTAFEVMVDGEGFGAITTLCGGG---------------------RYNGLVEEIGGPETPGIGFALSIERAIMALEAQQ..................... 321

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Li W, Godzik A. cd-hit: a fast program for clustering and comparing large sets of protein or nucleotide sequences. Bioinformatics. 2006 May 26;