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Query: 5w25_A mol:protein length:616 Aspartate--tRNA(Asp/Asn) ligase, from PDB1018

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MGSSSSGLVPRGSHVFVLRSHAAGLLREGDAGQQVTLAGWVARRRDHGGVIFIDLRDASGIAQVVFRDPQDTEVLAQAHRLRAEFCVSVAGVVEIRPEGNANPEIATGEIEVNATSLTVLGECAPLPFQLDEPAGEELRLKYRYLDLRRDDPAAAIRLRSRVNAAARAVLARHDFVEIETPTITRSTPEGARDFLVPARLHPGSFYALPQSPQLFKQLLMVAGMERYYQIARCYRDEDFRADRQPEFTQLDMEMSFVDAEDIIAISEEVLTELWALIGYRIPTPIPRIGYAEAMRRFGTDKPDLRFGLELVECTDFFSDTTFRVFQAPYVGAVVMPGGASQPRRTLDGWQDWAKQRGHRGLAYVLVAEDGTLGGPVAKNLTEAERTGLADHVGAKPGDCIFFSAGPVKSSRALLGAARVEIANRLGLIDPDAWAFVWVVDPPLFEPADEATAAGEVAVGSGAWTAVHHAFTAPKPEWEDRIESDTGSVLADAYDIVCNGHEIGGGSVRIHRRDIQERVFAVMGLDKAEAEEKFGFLLEAFMFGAPPHGGIAFGWDRTTALLAGMDSIREVIAFPKTGGGVDPLTDAPAPITAQQRKESGIDAQPKRVQQALast
1 -190.000[J] COG0173 Aspartyl-tRNA synthetase  ali follow..  45  1.................MRTNYCGLISEQYLDQTVTVKGWVHRRRDHGGVIFIDLRDREGIVQVVIDPDT-PEAFAAADSSRNEYVLSITGRVRNRPEGTTNDKMISGKIEILAKEIEVLNAAATPPFQIDENISENVRLTNRVIDLRRPVMQRNLRLRYQVAMGVRRYLDAQGFIDIETPMLTRSTPEGARDYLVPSRVHPGEFFALPQSPQLFKQLLMVAGFDRYYQITKCFRDEDLRADRQPEFTQIDLETSFLNEDEIMDITEGMAKQVFKDALNVDLGDFPRMPYSEAMFYYGSDKPDMRINLKFTELTDLMKTEEFKVFRGAADMKGGRPNGAEFSRKEIDEYTKFVGIYGAKGLAYIKVNDDSGLQSPIVKYLSENALKEIIARTGAQNGDIIFFGADKAKVVNEAIGALRIKVGLEHNGYFTDEWKPLWVVDFPMFEYDE----------EADRYVAVHHPFTAPKEGHEDLMVSDPANCLARAYDMVLNGWEIGGGSIRIHRADVQEKVFAALKISPEEQQEKFGFLLDNLKFGAPPHGGLAFGLDRLVTLMTGAESIRDVIAFPKTQRAQCLLTNAPNSVDDKQLRELSLRLRQKATETK 600
2 -141.000[J] KOG2411 Aspartyl-tRNA synthetase, mitochondrial  ali follow..  37  1.......................................................................................................................................................MQYNLRLRSQMVMKMREYLNLHGFVDIETPTLFKRTPGGAKEFLVPSR-EPGKFCSLPQSPQQFKQLLMVGGLDRYFQVARCYRDEGSRPDRQPEFTQIDIEMSFVDQTGIQSLIEGLLQYSWPNDKDPVVVPFPTMTFAEVLATYGTDKPDTRFGMKIIDISDVFRNTEIGFLQDALSKPHGTEGAKYLKRKDIESIRNFAADHFNQEILPVFLNANRNWNSPVANFIMESQRLELIRLMETQEEDVVLLTAGEHNKACSLLGKLRLECADLVVLRDPTLFSFLWVVDFPLFL---------PKEESPRELESAHHPFTAPHPSDIHLLYTEPKKARSQHYDLVLNGNEIGGGSIRIHNAELQRYILATLL---KEDVKMLSHLLQALDYGAPPHGGIALGLDRLICLVTGSPSIRDVIAFPKSFRGHDLMSNTPDSVPPEELKPYHIRVSKPTDSKA 459
3 -93.300[J] KOG0556 Aspartyl-tRNA synthetase  ali follow..  20  75.KYGDLPLNRSTARPGRTYT-QISDISAKNDGQTVLLRARVYTSRLQGKMCFFSLRQKYDTIQALAVVNKSKQMVKWCGSISLESIVLVEGIVKKSPEIIKSATV--QDAEIHISSIYVISPIKNLPFLVEDRVNLDTRLDNRVLDLRTPTNQAIFDIQAGICQAFREFLLSNSFNEIHTPKMSGASSEGGSNVFKIQYFKTDGF--LSQSPQLYKQMLIAADRERVFEIGPVFRAEDSNTYRHTEFTGLDLEMAFNEYHEVMEFIEKLFLYIFKTIREKPDADRIRFHFKDAVKLLKEAGYRKQ------------LVPGQKVPEDEEFHYCEDPEFDDFSTPEERALGQIVRE--------------------------------------------------------------------------KYHTDFYVIDKYP----------------------SSVRPFYT--------MPDPEDPRYSNSYDFFMKGQEIMSGAQRIHDPELLVERMKALGVSPDVG---LQQYIDAFAIGCPPHAGGGIGLERVVMFYLNLPNIRLASSFPRDPK................................ 576
4 -80.200[J] COG1190 Lysyl-tRNA synthetase (class II)  ali follow..  21  28.VLRGKG-IAFPNDF--RRENLSDQLHAEFLNIDVTVAGRMMTRRIMGKASFVTLQDVGGRIQLYVSRDDEGVYNEEFKKWDLGDILGARGKLF---------KTKTGELSIHCSELRLLTKARPLPDKFHGLADQETRYRQRYLDLANDESRHTFKVRSQVMSGIRSFMVEKGFMEVETPMMQVIPGGASARPFVTHHNALDIDMYLRIAPELYLKRLVVGGFERVFEINRNFRNEGVSPRHNPEFTMMELYMAYADYKDLIVLTEELFRTLTETILGSSVVQYGEQTFDFGKPFAKLTMKEAICKYRPETNVADLDDMD--------------------------------------------------------KAVAIAESLGIKVEKSWGLGRIQ---------------------------------------------------CEIFEETAESHLIQPTFITEYPAEVSPLARRNDDNPFITDRFEFFIGGREIGNGFSELNDAEDQAQRFADQVSGDDEAMFYDEDYITALEHGLPPTAGLGIGIDRMVMLFTNSHTIRDVILFPAMRPVK.............................. 505
5 -79.700[J] KOG1885 Lysyl-tRNA synthetase (class II)  ali follow..  17  86.QLKVNGEDPYPHKF--HVDISLTDFIQKYTDITLKVAGRIHAKRASGKLIFYDLRGEGVKLQVMANSRNEEEFIHINNKLRRGDIIGVQGNPG---------KTKKGELSIIPYEITLLSPCHMLPHLHFGLKDKETRYRQRYLDLLNDFVRQKFIIRSKIITYIRSFLDELGFLEIETPMMNIIPGGAVAKPFITYHNELDMNLYMRIAPELYHKMLVVGGIDRVYEIGRQFRNEGIDLTHNPEFTTCEFYMAYADYHDLMEITEKMVSGMVKHITGSY-----KVTYHPDGPEGQAYDVDFTPPFRRINMVEELEKALGMKLPET---------------------------------------NLFETEETRKILDDICVAKAVECPPPRTTARLL---------------------------------------------------DKLVGEFLEVTCINPTFICDHPQIMSPLAKWHRSKEGLTERFELFVMKKEICNAYTELNDPMRQRQLFEEQAKGDDEAMFIDENFCTALEYGLPPTAGWGMGIDRVAMFLTDSNNIKEVLLFPAMKPEDKKENVATTDTLESTTVGTSV.......... 597
6 -78.600[J] COG0017 Aspartyl/asparaginyl-tRNA synthetases  ali follow..  23  9...........................KDHLNQDVTIGAWLTNKRSSGKIAFLQLRDGTGFMQGVVVKSEDEEVFKLAKEIAQESSLYVTGTITEDNRSD-------LGYEMQVKSIEVISEAHDYPIT-PKNHGTEFLMDHRHLWLRSKKQHAVMKIRNEVIRATYEFFNKDGFTKVDPPILTASAPEGTSELFHTKYFDQDAF--LSQSGQLYLEAA-AMAHGKVFSFGPTFRAEKSKTRRHIEFWMIEGEMAFTNHAESLEIQEQYVTHVVKSVLENVATPFPRISYDDAIE---------------------------------------------------------------------FLKAEGFDDIEWGEDFGAPHETAIANHYD----------------------------------------LPVFITNYP----------------------TKIKPFYM--------QPNPENEETVLCADLIAGYGEIIGGSERVDDLELLEQRVKEHGLDEEA----YSYYLDLRRYGSVPHCGFGLGLERTVAWISGVEHVRETAPFPRLLN................................ 426
7 -77.900[J] KOG0554 Asparaginyl-tRNA synthetase (mitochondrial)  ali follow..  19  74VESYEKRFGSKVGEF--RKKLRIAEVKLSRVGQSLNIMGWVRTLRSQSSVTFIEINDGSCLLQCVMTSDAEGYDQVESGSILTGASVSVQGTIVASQGTKQK-------VELKVEKIIVVGECDSSYPIQKKRVSREFLRTKAHLRPRTNTFGAVARVRNTLAYATHKFFQESGFVWVASPIITASDCEGAGEQFCVTTLIPGKPAFLTVSGQLNGE-TYATALSDVYTFGPTFRAENSNTSRHAEFWMIEPELAFADLDDDMACATAYLQYVVKYVLDNCKEDMEFFDTWIEKGIIRRLSDVAEKEFLQLGYTDAIE---------------------------------------------------------------------------------ILLKANKKFDFPVKWGLDLQSEHERYITEEAFGGRPVIIRDY-------------------------------PKEIKAFYMRENDDGKTVAAMDMLVPRIELIGGSQREERLEVLEARLD----ELKLNKESYWWYLDLRRYGSVPHAGFGLGFERLVQFVTGIDNIRDVIPFPRTPASAEF............................ 567
8 -76.600[J] KOG0555 Asparaginyl-tRNA synthetase  ali follow..  22  93.EAKKITFSLDKSLPEAKVIKI--GESVQHRDQRVSIKAWVHRLRRQGKLMFLVLRDGYGFLQCVLNDKLCQS--YDAVTLSTETSVQVYGIIKALPDG----KSAPDGHELTVDYWEVIGKAPAIDNVLNESAGVDVMLDNRHLVIRGENASRILRIRAAATRAMRDHFFAAGYTEVAPPTLVQTQVEGGSTLFGLDYYGEPAY--LTQSSQLYLE-TCNAALGDVYCISQSYRAEKSRTRRHSEYQHVEAECAFITFDQLMDRIEALVCDTVDRLLADPARPFKRMPYKEAIEWLQKNDVRNEMGEKFVYGEDIAEAAE--------------------------------------------------------------------------------------------------------RRMTDTIGVPILLNRFP----------------------HGIKAF---------MPRCADDNELTESVDLLMPGVEIVGGSMRIWKEDQLLAAFEKGGLDSKN----YYWYMDQRKYGSVPHGGYGLGLERFICWLTDTNHIRDVCLYPRFVG................................ 541
9 -60.300[J] COG2269 Truncated, possibly inactive, lysyl-tRNA synthetase (class II)  ali follow..  18  1..........................................................................................................MSQLSLAFCSER-VQFVISVSCDEPPMTNS---------DWMPTASISQLKQRATLLRQIREFFAERNVLEVETPAMSHATVHTFKTEFVGPGYAKGSALHLMTSPEFHMKRLLAAGSGCIYQLGKAFRNEENGRYHNPEFTMLEWYRIGFDHHALMDEMDALLQLVLRCG------SAERMTYQEAFLNV---------------------------------------LGVCPLEEEMRELKQVAATLGLSDIAEPEEDRDTLLQLLFSIGIEPKIGQ-----------------------------------------------------------------------------ITPAFVYDFPASQAALAKINPADPRVADRFEVYFKGIELANGFHELDNPAEQLARFKADNAMGLTEQPIDYHLIAALEAGLPECAGVALGIDRLIMLALGEDHIDKVTAFPFPRA................................ 349
10 -42.300[E] COG2502 Asparagine synthetase A  ali follow..  13  1................................................................................................................................................MKKTFILQQQEIFVKNTFTQNLIEQL---GIIEVQGPILSQVGNGMQDNL-VNVKCIPNAVFEVVHSLAKWKRHTLAEDEGLFVHMKALRPDEDSLDPTH-YVDQWDWEKVIPEGRRNFAYLKETVNSIYRAIRLTLPKQITFVHSEDLVKRYPDLSSKERENAICKEYGAVF---------------------------------------------------------------------------------------------------------------------------------LIGIGGKLSDGKPHDGRAPDYDDWTTESENGYKGLNGD----ILVWNDQLGKAFELSSMGIRVDESALRLQ----VGLTGDEDHLKMDWHQDLLNGKLPLTIGGGIGQSRLAMLLLRKKHIGEVQSWPKE.................................. 321
11 -12.700[J] COG0442 Prolyl-tRNA synthetase  ali follow..  12  1..............................................................................................MRTSQYLLSTQKETPADAEVISHQLMLRAGMIRKLASGL--------YTWLPT-------GVRVLKKVENIVREEMNNAGAIEVSMPVVQPAD-EQYGPELLRFVDRGERPFVLGPTHEEVITDLIRGEINSYFQIQTKFRDE-----RAREFLMKDAYSFHTTQESLQETYDAM-YTAYSKIFSRMDLNFRAVL-ADTGSIGGSASHEFQVLAESGEDDIVFSTGSDYAANIEFAEALAPTEPRAPATEELRIVDTPNAKTIAELVEQFKLPIEKTVKTLLVHAHEESGHKLVALLVDLNEIKAEKLPQVAKPLTFASEEEIRAAIGAGPGSLGPVNLSLPVIADHSVAVMSDFGAGANIDGKHYFGINWERD-LALPLVADLRNVVEGDISPDGKGTLQIKRGIEVG------HIFQLGTKYSEVMKATVQGEDGR-----QVMTMGC-----YGIGVSRVVAAAIEQNHDDRGIIWPDAIAPFQVAILPMNMHKSFRVKELAEELYTTLRSHG 504
12 -12.300[S] COG3111 Uncharacterized conserved protein  ali follow..  18  48.....................TVESAKSLRDDTWVTLRGNIVERISDDLYVF---KDASGTINVDIDHKRWNG-----VTVTPKDTVEIQGEV----------DKDWNSVEIDVKQIRKVNP........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ 130
13 -10.800[J] KOG1936 Histidyl-tRNA synthetase  ali follow..  11  48....................................................................................................................................AHQEKPNFIIKTPKGTRDLSPQHMVVREKILDLVISCFKRHGAKGMDTPATLTEKYGEDSGLMYDLKDQGGELLSLYDLTVPFARYLAMNKVKKRYHVGKVWRRETIVQGRYREFCQCDFDIPMIPDAECLKIMCEILSGL------------------------QLGDFLIKVN-------------DRRIVDGMFAVCGVPESKFRAICSSIDKLDKMAWKDVRHEMVVKKGLAPEVADRIGDYVQCHGGVSLVEQMFQDPRLSQNKQALEGLGDLKLLFEYLTLFGIADKISFDLSLARGLDYYTGVIYEAVLLQTPTQAGEEPLN-------------------------------------GSVAAGG--------------------------RYDGLVGMFD----PCVGLSIGVERIFYIVEQRMKTKQVFVATPQKNFLQERLKLIAELWDSGIK.............. 438
14 -10.000[J] COG0124 Histidyl-tRNA synthetase  ali follow..  10  1...........................................................................................................................................MAIQIPRGTQDILPGDVETWQWIEQKAYDLCRRYNYQEIRVPMFEHTTTDIVQKEMYTFEDRGGRSLTLPEGTASVTRAYVSNKL-KLFYIGPMFRYERPQSGRMRQFVQFGVEA------------------------------------------LGSADPAIDAEV-LALVMRFYEELGLKNLKLVINSLGDTDSRLAHREALVNHFKPRIHE--------------------FCNDCQDRLEKNPLRILDCKKDRDHELMGTAPSIHDYLSTESKAYFEKVQSYLTA---------------------------------LNIPFVVDATLVRGLDYYNHTAFEVMVDGEGFGAITTLCGGG--------------------------RYNGLVEEIGGPETPGIGFALSIERAIMALEAQQAK-DCYVVTLGEAAKDKGVELVYQLRNAGIS.............. 358
15 -9.630[E] COG3705 ATP phosphoribosyltransferase involved in histidine biosynthesis  ali follow..  10  11....................................................................................................................................................ADVLPTNARQLESAREQLLALFRVHGYELVQPPLMTHIDAGLSLKTILVTDRLSGRQLGIR--ADITPQVARIDAHLRLCYAGPVLHAQSDGLLNMREPLQAGAEMDIRGDIELIDLMLKSMKIA-------------------DMGKVLLSLGHIGIFRALSDAAHLDAGQSATLLA-------------LMQDKDTETVEAQVKAWK----------------------LDGMWAKAFSLLPRLYGGREVLSDARGRLPDLSAVGGALGELQAVCDAFPDCEIHI------------------------------------------------DLSELRVDNYAAYAADFAVARGG-------------------------RYDGLGGYFGRARPA--GFSFDLRSFIGRLPAIERQPAVLVDAEDAEAAHEAV--------EALREQGQCVVIDYGIGH 361

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Zhao Y, Hong DH, Pawlyk B, Yue G, Adamian M, Grynberg M, Godzik A., Li T. The retinitis pigmentosa GTPase regulator (RPGR)- interacting protein: subserving RPGR function and participating in disk morphogenesis. Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):3965-70. Epub 2003 Mar 21.