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Query: PF09847.9; O29125_ARCFU/30-435; Membrane protein of 12 TMs, from PfamA32U

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst SLRVQVAKSFFIMTFLGSFLCWVAFISSGLGLSLIFTLSLVFSQIYPAQNIAISASSRVFEPLRYLPVRFSERMLVVFFIDSINILAFATPTIAVLMVKNLYFGLYSLLWIIAAILLGYSMVFLYYALFGVKVRSGFSKSVLAGILFFAVLVFALRRFQEIPDLTPYLTPHLLLLSYAASSATIKLSTGRVWRSILNPEIVEVKGSSRLSSGSPLRAMLIKDFRLILRKNALFPLIVPLVIVMPNVVSIANMPNLSIFIITTISTLSTIDLRIIGNLENVDFLRMLPLSKRGFVMSKACLIFVISFAASLPAGSIAFIVSQNPFYLFMAFAIPAIVSMLSSLIIFWQKGEEIYFPEVGFLKWIGLLLVNFGAVYAVLSPRFILSQPVADIISSVLTLLAMTALFEKLast
1 -142.000[R] COG3368 Predicted permease  ali follow..  100  30SLRVQVAKSFFIMTFLGSFLCWVAFISSGLGLSLIFTLSLVFSQIYPAQNIAISASSRVFEPLRYLPVRFSERMLVVFFIDSINILAFATPTIAVLMVKNLYFGLYSLLWIIAAILLGYSMVFLYYALFGVKVRSGFSKSVLAGILFFAVLVFALRRFQEIPDLTPYLTPHLLLLSYAASSATIKLSTGRVWRSILNPEIVEVKGSSRLSSGSPLRAMLIKDFRLILRKNALFPLIVPLVIVMPNVVSIANMPNLSIFIITTISTLSTIDLRIIGNLENVDFLRMLPLSKRGFVMSKACLIFVISFAASLPAGSIAFIVSQNPFYLFMAFAIPAIVSMLSSLIIFWQKGEEIYFPEVGFLKWIGLLLVNFGAVYAVLSPRFILSQPVADIISSVLTLLAMTALFEK 435
2 -6.110[O] COG2386 ABC-type transport system involved in cytochrome c biogenesis, permease component  ali follow..  11  2......................................................................................................................................................................................................................FISVLRRELKIAFRKGAEIVNPLWFFLIVITLFPLGRIAPGIVWVAALLASLLSLERLFRDDFYDLEQLLLLPTPLPLTVLGKVCAHWVVTGLPLLVLSPLVALLLSLDVNTAIAMGLTLLIGAIGVALTVGLRKGGVLLSLLVLPLYIPVLIFATAAIDAASM-----AMPIDGYLAILGAMLAGSVTL.. 205
3 -5.760[S] COG4200 Uncharacterized protein conserved in bacteria  ali follow..  12  5........................................................................................................................................................................................................................VLEVEWNKLKHMKVWIIVIAGPLLASVIGFFPYFTIDAAHSALFLPLLTGIYAALICSYEHGGWKQLLALPVERYHVYIAKFVVIITLLLLTQIVFFFSVWLVGVARGYSISSFTYMPLLVSVLAGFL-------SCLPLAALQLWLATRFTSFNVMLTVPAILIANSEVLGPLYPWAHPLLSMTQ.... 203
4 -5.730[V] COG0842 ABC-type multidrug transport system, permease component  ali follow..  13  6....................................................................................................................................................................................................................VSTLILTKREIIKWVNRRSLVSIITPIFWIALF-YFTYVATGMLAVFSLFQSMFGAVGVVFDRRIGYLTRLLASPIPRFSIFASKVLGTLFRITVLSLILLAIAYPLDLVMAWLVLMLMSLGLSSLFTGMAFNITHQEVLFFPIDLMPNWLKTVAQVNPITHAADLVRYYLGKPLEDPVMSIAYLAVLTLFL.. 268
5 -4.730[S] KOG2946 Uncharacterized conserved protein  ali follow..  13  39....................................................................................................................................................................................................................EPIRETVLRDIRAVGIKFYHVLY--PLVLCTFMATILQNGPEFAQVFVIVWIGAAVVTLNSKLLGGNISFFQSVCV----------LGYCLTPVAISLIVCRVILLATQTRLLFFLRFVTTTIGFA-----------------------WATYASFVFLGQSQPPHRKPLAVYPIF-LFFFIISWLVL...... 215
6 -4.700[P] KOG4505 Na+/H+ antiporter  ali follow..  40........EATMATATGLIFGPTSWGNTDYITEELARVLLVVEVFAAGAELPRAYMLRHWRSMFVMLL-LVSTGFMYALIPRLSFLESLA---ACITATDPV--------LASSIVGKGKFARRVPGHLRNMLLAESGCNDGMAIPFLYLAIYLIIE--------------------PARHAGRDWVCIIILYECTFGCVLGAIIGVIAR-----KMIKFSERRGLMDRESFLVFYFVLALFCGGIGTIIGVDDLLVSFCAGAAFSWDSWFSKKTEESHVSNVIDLLLNLSFFVYVGAIMPWPQFHMPHMDLSVWR--------LVVLAICILIARRIPAVLLFKSFVPDIINWREALFAGHFGPI--GVGALYTCLVARAELEVHCIQVMWPVVCFLVLSSII.. 425
7 -4.590[TV] KOG3966 p53-mediated apoptosis protein EI24/PIG8  ali follow..  14  108........................................................................................................................................................................................................................KIAKKLFKCCMLNGGF--TWLSIVLFENALLPTLKFCLTIFYGAHSETLPVVWGWLHPILSLLFGMMWVLPIFMLSKIVSKLVADFLFSMVVQMLFLVQSMLVNLVPVKYVGSSLCFVHLCLLYSLYSFEYKHRRLTYIEKNWPYFFG-----FGIPLTVLTSSVIVSSCIFSIFFPLFILSGNEA.... 323
8 -4.580[S] KOG2889 Predicted PRP38-like splicing factor  ali follow..  1........................................................................................................................................................................................................................................................MANRTEKAAKTVKGTNPQFLVEKIIRQRIYDSMYWKEH------FALTAELVVDKGMDLRYIGGIYAGNIKPTPFLCLALKMLQIQPDKDIVLEF--------IQQEEFKYIRALGAMYLRLTFIYKYLEPLYNDFRKLR.................. 131
9 -4.520[S] COG4844 Uncharacterized protein conserved in bacteria  ali follow..  12  48.....................................................................................................................................................................................................................................................................................................................................................................................FALVNGEVVMGETPAELVENIYTFIEENPMF.. 78
10 -4.350[P] COG3303 Formate-dependent nitrite reductase, periplasmic cytochrome c552 subunit  ali follow..  25  5....................................................................................................................................................................................................................................................................................................................................................................LRFV-WILIIILNF-----LLN--FITTNGVIIVNAFKKSLIVAASF... 44

FFAS is supported by the NIH grant R01-GM087218-01
1 3 5 0 8 7   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Pawlowski K, Pio F, Chu Z, Reed JC, Godzik A. PAAD - a new protein domain associated with apoptosis, cancer and autoimmune diseases. Trends Biochem Sci. 2001 Feb;26(2):85-7.