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Query: [R] COG1159 GTPase, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MSTDKTYCGFIAIVGRPNVGKSTLLNKLLGQKISITSRKAQTTRHRIVGIHTEGPYQAIYVDTPGLHMEEKRAINRLMNKAASSSIGDVELVIFVVEGTRWTPDDEMVLNKLRDGKAPVILAVNKVDNVQEKVDLLPHLQFLASQMNFLDIVPISAETGMNVDTIAGIVRKHLPEAIHHFPEDYITDRSQRFMASEIIREKLMRFLGAELPYSVTVEIERFVTNERGGYDINGLILVEREGQKKMVIGNKGAKIKTIGIEARKDMQEMFEAPVHLELWVKVKSGWADDERALRSLGYVDDLLast
1 -125.000[R] COG1159 GTPase  ali  100  1MSTDKTYCGFIAIVGRPNVGKSTLLNKLLGQKISITSRKAQTTRHRIVGIHTEGPYQAIYVDTPGLHMEEKRAINRLMNKAASSSIGDVELVIFVVEGTRWTPDDEMVLNKLRDGKAPVILAVNKVDNVQEKVDLLPHLQFLASQMNFLDIVPISAETGMNVDTIAGIVRKHLPEAIHHFPEDYITDRSQRFMASEIIREKLMRFLGAELPYSVTVEIERFVTNERGGYDINGLILVEREGQKKMVIGNKGAKIKTIGIEARKDMQEMFEAPVHLELWVKVKSGWADDERALRSLGYVDDL 301
2 -39.600[R] COG3596 Predicted GTPase  ali follow..  16  41..........IGIMGKTGAGKSSLCNALFAGEVSPVSDVAACTRDPLRFRLQIGEHFMTIVDLPGV--GESGVRDTEYAALYREQLPRLDLILWLIKADDRLATDEHFYRQVEAYRHKMLFVISQSDKAEPQNISRKICLLHELFQPVHPVCAVSVRLQWGLRVMAERMIKCLPREPSSPVVALLQHPFRTWVAREQARDDFGETVDTIL........................................................................................... 253
3 -37.500[R] COG1084 Predicted GTPase  ali follow..  21  165..........VVIAGFPNVGKSTLLRTLTGAEPEV-ADYPFTTKGIQIGHLERKWKRIQVIDTPGLLDRPVEDMNNIELQAMVALENIADVIMFIFDASETCGYTSLYLGIRSVFDIPVVTVFNKMDLAENVKYLEEYINMVE------DPLKVSAFEGRGVSKIIKKLEGLYEKETREAHDN...................................................................................................................... 335
4 -32.400[R] COG1160 Predicted GTPases  ali follow..  20  6..........VALVGRPNVGKSTLFNRLTRTRDALVADFPGLTRDRKYGHAHIAGYDFIVIDTGGI-DGTEEGVEEKMAEQSLLAIDEADIVLFLVDARAGTAADIGIANYLRQQNKITVVVANKTDGIDADSHCAEFYQ-----LGLGEIEQIAASQGRGVTQLMEQVLAPFAEKMENADENDRTSEEEQDEWEQ--EFDFDSEEDTALIDDALDEELEEEQDKNIKIAIVGRPNVGKSTLTNRILGEDRVVVFDMPGTTRDSIYIPM................................ 258
5 -32.100[E] COG4917 Ethanolamine utilization protein  ali follow..  20  4..........IAFVGSVGAGKTTLFNALQGNYTLA--RKTQAVEF----------NDKGDIDTPGEYFN-----HPRWYHALITTLQDVDMLIYVHGANDPESRLPAGLLDIG-VSKRQIAVISKTDM--PDADVAATRKLLLETGFEEPMFELNSHDPQSVQQLVDYLASLTKQEE............................................................................................................................ 150
6 -31.700[R] KOG2486 Predicted GTPase  ali follow..  22  138..........FALVGRSNVGKSSLLNSLVRRKRLALTSKKPGKTQCI---HFRINDKWYLVDLPGY-PHELKQDWNKFTKDYFLNRSTLVSVFLLVDASIPKPIDLEYASWLGQNQVPMTLIFTKCDKRKKKKNGGKKPEANIKEFTTPPWIMTSSVTNQGRDEILLHMAQLRNY.............................................................................................................................. 314
7 -28.100[R] COG0218 Predicted GTPase  ali follow..  21  28..........IALAGRSNVGKSSFINTMLNRKLARTSGKPGKTQL-----FFNIDDKMRFVDVPGY-SKKEREKWGCMIEEYLTTRENLRAVVSLVDLRHDPSADVQMYEFLKYYEIPVIIVATKADKIPRGKKHESAIKKKLNFDPSDDFILFSSVSKAGMDEAWDAILEKL................................................................................................................................ 195
8 -26.200[R] KOG1490 GTP-binding protein CRFG/NOG1 (ODN superfamily)  ali follow..  19  171..........VLICGYPNVGKSSFMNKVTRADVDV-QPYAFTTKSLFVGHTDYKYLRYQVIDTPGILDRPFEDRNEMCSITALAHLRAAVLFFLDISGSYTIAQQAALFHSIKSMNKPLVIVCNKTDLMPMENISEEDRKLIEEMKS-QVLLKMSTLTDEGVMSVKNAACERL................................................................................................................................ 349
9 -24.700[R] COG0486 Predicted GTPase  ali follow..  19  225......REGMVVIAGRPNAGKSSLLNALAGREAAIVTDIAGTTRDVLREHIHIDGMPLHIIDTAGLR-EATDEVERIGIVRAWSEIEQADRILLMLDSTEADNQDLSEFLTKLPSNIPVTIVRNKADLSGENEG--------IVEQNGYTVITLSAKTQQGIALLREHLKQSMGYQTN--EGGFLARRRHLEALEQAATHLQQGHVQLTQFYAGELLAEELRRVQNHLSEITGQFTSDD---SSFCIGK.................................................... 465
10 -24.600[R] COG1163 Predicted GTPase  ali follow..  13  65.......VASVGFVGFPSVGKSTLLSKLTGTESEA-AEYEFTTLVTVPGVIRYKGAKIQMLDLPGIIDGAKD--GRGRGKQVIAVARTCNLLFIILDVNKPLHHKQIIEKELEGNKTPPDILIKKKEKGGISITNTVPLTHLGNDEIRAVMSEIAFRCDATVDDLIDVLEASSRRYMPAIYVLNKIDSLSIEELELLYRIPNAVPISSGQDWNLDELLQVMWDRLNLVRIYTKPKGQIPDFTDPVVLRSDRCSVKDFCNQIHKSLVDDF----------RNALVYGSSVKH-QYVGLSHIL 358
11 -24.400[J] KOG1191 Mitochondrial GTPase  ali follow..  23  351......QSGLIAIVGRPNVGKSSLLNAWSKSERAIVTEVAGTTRDVVEANVTVRGVPITLLDTAGIR-ETNDIVEKIGVERSETAAKVADVIIMAVSAVEGTEEDTELLRKIQSLKQPMILVMNKID-CAPPGSCDQLEDQRKKEEVFHKSVFTSAVTGQGIEELEDAILEILGLDRVPTGGHQWTVNQRQCEQLVRTKEALVRLREAEDEIPIDFWTIELREAALSLAQISGQDVSEE---AKFCIGK.................................................... 613
12 -23.700[T] KOG1487 GTP-binding protein DRG1 (ODN superfamily)  ali follow..  13  64.......DARIGFVGFPSVGKSTLLSNLAGVYSEV-AAYEFTTLTTVPGVIRYKGAKIQLLDLPGIIEGAKD--GKGRGRQVIAVARTCNLILIVLDVLKPLGHKKIIENELEGNSKPPNIGFKKKDKGGINLTATCPQSELDAETVKSILAEYKIHNADTADDLIDVVEGNRVYIPCIYVLNK-IDQISIEELDIIYKVPHCVPISAHHRWNFDDLLEKIWDYLKLVRIYTKPKGQLPDYTSPVVLPYSRTTVEDFCMKIHKNLIKEF----------KYALVWGLSVKH-QKVGKDHTL 356
13 -23.700[T] KOG1486 GTP-binding protein DRG2 (ODN superfamily)  ali follow..  13  62.......HGRVALIGFPSVGKSTLLTMLTGTHSEA-ASYEFTTLTCIPGVIHYNDTKIQLLDLPGIIEGASE--GKGRGRQVIAVAKSSDLVLMVLDASKSEGHRQILTKELEANKTPPQIYFKKKKTGGISFNTTAPLTHIDEKLCYQILHEYKIHNAETVDDFIDVIEGNRKYIKCVYVYNK-IDVVGIDDVDRLSRQPNSIVISCNLKLNLDRLLARMWDEMGLVRVYSKPQGQQPDFDEPFVL-RGGCTVEDFCNHVHRTLVK-----------MKYALVWGTSTRH-QNCGLSQHL 356
14 -21.700[P] COG0370 Fe2+ transport system protein B  ali follow..  19  6..........YCILGNPNTGKTSLFNALTGSYEY-VGNWSGVTVEKKVGTLRSKTGKLI--DLPGIYDLNPISRDETVVTRFLLE-EKFDCMLNIVDSSQ--ERNLNLTVQLLEYGAPVVMGLNMIDVAAGRGIHLNIQNLAKKL---IPILPVVARSGKGTEDILSTLSEKH................................................................................................................................ 161
15 -19.900[R] COG2262 GTPases  ali follow..  19  200..........VSLVGYTNAGKSTLFNRITEARVYAADQLFATLDPTLRRIDVADVGETVLADTVGFIRHLPHDLVAAF-KATLQETRQATLLLHVIDAADVRVQENTVLEEIDAHEIPTLLVMNKIDMLEDFEPRIDRDEE-----NKPIRVWLSAQTGAGIPQLFQALTERL................................................................................................................................ 361
16 -18.200[R] KOG0410 Predicted GTP binding protein  ali follow..  23  312..........VSLVGYTNAGKSTLLNQLTGANVLAENRLFATLDPTTRRVQMQNGKEFLLTDTVGFIQKLPTTLVAAF-RATLEEIAESSLLVHVVDISHPLAEQQKVMSELDVSSIPKLVVWNKVDRVDDPQKVKLEAEE------TGDTICISALTGEGLDDFCNAVHEKLKDS............................................................................................................................. 475
17 -18.100[R] COG0536 Predicted GTPase  ali follow..  14  162..........VGLVGFPSAGKSSLISVMSAAKPKI-GDYPFTTLQPNLGVVNVGHETFTMADVPGLIPGASE--GKGLGLDFLRHIERTSVLVHVVDTATMDPGRDPISDLGDLSQRPRLVVLNKADVPEAEELAEFLKEDIEKQFG-WPVFIISAVARKGLDPLKYKLLEIVQDARKKRPKEKAESVIIKPKAVDHRTKGQFQIKPDPEVQGGFIITGEKPERWILQTDFENDEAVGYLADRLAKLG---DGLRKAGAHVGANV.................................... 431
18 -17.300[R] KOG1489 Predicted GTP-binding protein (ODN superfamily)  ali follow..  23  342..........LGLIGLPNAGKSTILNKISNAKPKI-GHWQFTTLSPTIGTVSFGQDVFTVADIPGIIQGASL--DKGMGLEFLRHIERSNGWVFVLDLSNKNPLNQLLIEEVGTKTKNILIVCNKVDIDAEKSESFAKYLQVEKFSKSQDCVPISALREKT............................................................................................................................................ 499
19 -16.600[V] KOG1707 Predicted Ras related/Rac-GTP binding protein  ali follow..  12  17..........IVVVGEKGSGKSSLIMAAARNTFH-PNIPSLLPYTNLPSEFFPDRIPATVIDTSS---------RPEDKGKVVKEVRQADAIVLTFAFDRPETLDRLSKYWLPLFRVPIIVAGYEVDNKEAYNHFSITSALMKQYREVETSIQWSAQRLDQAKDVLYYAQKAV-----IDPVGPVFDQENNVLKPRCIAKRIFLLSDHNMDGIL---------SDEELNELQKKCFDTPLVPCEIMKNVMQVTFPQGVNERGLTLDGFLFLNTRLIEEARIQTLWT----MLRKFGYSNDL 291
20 -15.900[O] KOG0448 Mitofusin 1 GTPase, involved in mitochondrila biogenesis  ali follow..  13  78..........VAFFGRTSSGKSSVINAMLWDKVLPSGIGHITN---FLSVEGTDGDKLVLVDSPGTDVTTE------LDSWIDKFCLDADVFVLVANSESTMNTEKHFFHKVNEWKPNIFILNNRWDASASEPELVEELKVANALEAQNRIFFVSAKEVQEFQNFEQIFEECISQSAVKTKFEQHTIRAKQILATVKNIMDSVNLAAEDKRHYSVEEREDQIDRLDFIRNQMNLLTLDVKKKIKEVTEEVANKVSCAMTDEICRLSVLVDE.............................. 426
21 -15.500[TU] KOG1954 Endocytosis/signaling protein EHD1  ali follow..  22  94.........MILLVGQYSTGKTTFIRYLLESDFPGIRIGPEPTTDRFIAVMHGDEESVTIVDTPGILSGEKQRIDR-FTGVLEWFAERVDRIILLFDAHKLDISDERCIEALAGNEDKIRIVLNKSDMVDHQQLM...................................................................................................................................................................... 264
22 -15.400[OK] COG0378 Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase  ali follow..  13  7..........IGVGGPVGAGKTMLIERLTGYSMAAITNDIYTKEDA---CDKHPDLQLLFLESGGDNLSAT------------FSPDLVDFSIYIIDVAQGEKIPRKGGQGMIKSD---LFIINKVDLAPYGANVEVMKADTLKSRGNKDFFVTNLKTDEGLKSVADWIEKRL................................................................................................................................ 199
23 -15.200[J] COG0012 Predicted GTPase, probable translation factor  ali follow..  18  3..........IGVVGKPNVGKSTFFSAATLVDVE-IANYPFTTIDANVGVTGLALIPVKMIDVAGLVPGAHE--GRGLGNKFLDDLRMASALIHVVDVTGKTEDLLAFASEIRRINKPMIIAANKADAASEEQINRLIKEGEKRG---YIVVPTSAAAELTLRKAAKAGFIDYIPGSSEFKILKDMNERQK--ALLMIKEKVLDRFGST-------VQEVINKAVFELLNLIPVYPVQDENKLTDQFGKKGSNPRDLAFKVHTDLGRGFLYAINAKTKRRIGEDYELQFNDIIKIVAVTK. 397
24 -15.200[U] KOG0090 Signal recognition particle receptor, beta subunit (small G protein superfamily)  ali follow..  16  58..........VLLSGLSGSGKTVLFYQLRDGSSSMEPNEGTFVLHNENNTKKGKVKPVHLIDVPG---------HSRLISKLEEYLPRAAAVVFVVDALEFLPNIRAASEYLIKNKTPVLLCCNKTDKAHTKEFIRKQMEKEIDKLRVSRSAISTADIANDF........................................................................................................................................... 217
25 -15.000[R] KOG2485 Conserved ATP/GTP binding protein  ali follow..  25  144..........VMVVGVPNVGKSALINSIHQLKRATVGPLPGVTQD-IAGFKIAHRPSIYVLDSPGVLVPSIPDIETGLKLALSGSVKDAQYFLAILN............................................................................................................................................................................................................ 248
26 -14.900[J] KOG1145 Mitochondrial translation initiation factor 2 (IF-2; GTPase)  ali follow..  21  179......RSPVVTIMGHVDHGKTTLLDKFRKTQVAAVETGGITQHIGAFLVSLPSGEKITFLDTPG---------HAAFSAMRARGAQVTDIVVLVVAADDGVKQTVESIQHAKDAQVPIILAVNKCDK-KVKKELLAYDVVCEDYGGDVQAVPVSALTGDNLMALAEAT---------------------------VALAEMLELKADPNGPVEGTVIESFTDKGRGLV---TTAIIQRGTLRKLVAGKCWAKVRLMFDENGKTIDE.................................. 409
27 -14.700[R] COG2229 Predicted GTPase  ali follow..  16  6..........IIFTGPVGVGKTTAIAAISDEALTLDRKRNTTVAMDYGAISLDEDTKVHLYGTPG---------QERFNFMWEILSQGSMGLVLLLDNARTNPLKDFFLHSFRGLKAPVVVGITKMD-IRSQPGIDVYHKYLAKHNLNVPVFEIDARKEDDVKQLVSAMLFSIDPG............................................................................................................................. 175
28 -14.500[J] KOG0466 Translation initiation factor 2, gamma subunit (eIF-2gamma; GTPase)  ali follow..  16  44..........IGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYAFRLVRHVSFVDCPG---------HDILMATMLNGAAVMDAALLLIAGNEQTSEHLAAIEIMK---KHILILQNKIDLVKERKEQYEQILAFVQGTVAEGIIPISAQLKYNIEVVCEYIVKKIPVPPRDFTSEPRLIVIRSFDVGGVAGGSILKKVGQETPGIVSKDSEGKLMCKSIFSKIVSLFAEHNDLQYAAPGGLIGVGTKIDPTLCRADRMV.................................. 354
29 -14.400[R] KOG0074 GTP-binding ADP-ribosylation factor-like protein ARL3  ali follow..  20  20..........ILLLGLDNAGKTTLLKQLASEDISHITPTQGFNIKSV----QSQGFKLNVWDIGG---------QRKIRPYWKNYFENTDILIYVIDSADRKRFEEELLEEEKLSCVPVLIFANKQDLAAPASEIAEGLNLHTIRDRVWQIQSCSALTGEGVQDGMNWVCKNVNA.............................................................................................................................. 179
30 -14.400[T] KOG3886 GTP-binding protein  ali follow..  14  43..........VLLMGKSGSGKTSMRSIIFANYIARDTRRLGATDVEHSHVRFLGNLVLNLWDCGG----QDTFMENYFTSQRDNIFRNVEVLIYVFDVESRELEKDSCLEAILQNSAKIFCLVHKMDLVQEDQRDLIFKEREEDLRRLSRPLECTSIWDETLYKAWSSIVYQL................................................................................................................................ 241
31 -14.400[U] KOG0076 GTP-binding ADP-ribosylation factor-like protein yARL3  ali follow..  21  20..........ILILGLDNAGKTTFLETLKKEAFKALEKIQPTVGQNVATIPVDSKQILKFWDVGG---------QESLRSMWSEYYSLCHGIIFIVDSSDRERLDESVVMDEEIEGVPILMLANKQDRRMEVQDIKEVFNKIAEHISARDVLPISALTGEGVKDAIEWMIVRLERNKKSRPP....................................................................................................................... 195
32 -14.200[UZ] KOG0073 GTP-binding ADP-ribosylation factor-like protein ARL2  ali follow..  17  19..........LLMLGLDNAGKTTILKKFNGEDIDTISPTLGFNIKTL----EHRGFKLNIWDVGG---------QKSLRSYWRNYFESTDGLIWVVDSADRQRMQDSLLVEERLAGATLLIFANKQDLALSSNAIREALELDSIRSHHWCIQGCSAVTGENLLPGIDWLLDDISS.............................................................................................................................. 178
33 -14.100[M] COG0481 Membrane GTPase LepA  ali follow..  15  7..........FSIIAHIDHGKSTLSDRLIQTCGGLSDREMEAQ-ERERGITDGETYQLNFIDTPG---------HVDFSYEVSRSLAACEGALLVVDAGQVEAQTLANCYTAIEMNLEVVPILNKIDLPAADPERVAEEIEDIVGIDAMEAVRCSAKTGVGIEDVLEEIVHKIP------APEGDPNAPLQALIIDSWFDNYLGVVSLVRIKNGTLRIKVMSTGQSYNVDRLGIFTPKQVDTTILNCGEVGWVVCAIKDILGAPVGDTLTSHVYAGLFPISSDDYEAFRDALGKLSLNDA. 322
34 -14.000[U] KOG0072 GTP-binding ADP-ribosylation factor-like protein ARL1  ali follow..  16  20..........ILILGLDGAGKTTILYRLQVGEVVTTIPTIGFNVEQV----TYKNLKFQVWDLGG---------QTSIRPYWRCYYSNTDAIIYVVDSADRDRIGIYMLREEELAGAILVVLANKQDMCMTVAEVHHALGLENLKNRTFQIFKTSATKGEGLDQAMDWLSNTLQS.............................................................................................................................. 179
35 -14.000[R] KOG0075 GTP-binding ADP-ribosylation factor-like protein  ali follow..  17  23..........LTLVGLQFSGKTTFVNVIASGQ--FAEDMIPTVGFNMRKI-TRGNVTIKVWDIGG---------QPRFRSMWERYCRGVNAIVYMVDAADLDKLEASLLDKPQLAGIPVLVLGNKRDLALDETGLIERMNLSSIQDREICCYSISCKEKDNIDITLQWLIQHSKS.............................................................................................................................. 183
36 -14.000[U] KOG0070 GTP-binding ADP-ribosylation factor Arf1  ali follow..  17  20..........ILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETV----EYKNISFTVWDVGG---------QDKIRPLWRHYFQNTQGLIFVVDSNDRDRVVERMLNEDELRDAVLLVFANKQDLAMNAAEITDKLGLHSLRQRHWYIQSTCATSGEGLYEGLDWLSNNIASKA............................................................................................................................ 181
37 -13.900[R] KOG2203 GTP-binding protein  ali follow..  14  33LSDCGLSYAVVAIMGPQSSGKSTLLNHLFKTSFREMAGRSQTTKGIWMARCVGIEPFTIAMDLEGTDGRERGEDDTTFKQSALFAIAVADIVLINMWCHDIGREQAANKPLLKTVKTTLLFVIRDKTKTPIELLERALREDIQKI--WDSVRKPEAHKNTPLNEFFNVMIVALSSSPGGLAGDRRGVVPASGFSFKVIKENRDLDLPAHKVMVATVRCEEIANEKLRDLATNESWLELHEAAEGGLVPGFGKKLSSILEKYFSEYDA.................................. 341
38 -13.900[U] KOG0071 GTP-binding ADP-ribosylation factor Arf6 (dArf3)  ali follow..  16  24..........ILMLGLDAAGKTTILYKLKLNQSVVTIPTVGFNVETV----TYKNIKFNVWDVGG---------QDKIRPLWRHYFTGTKGLIFVVDSADSNRISERIISDREMRDCLLLVLANKQDLALSPAQITDVLQLDKLKDRLWNVQPTCALTGDGLLEGLAWLSQNAKL.............................................................................................................................. 183
39 -13.800[R] COG1100 GTPase SAR1 and related small G proteins  ali follow..  18  21..........ILILGLDGAGKTTILYRLQIGEVVTTKPTIGFNVETL----SYKNLKLNVWDLGG---------QTSIRPYWRCYYADTAAVIFVVDSTDKDRMSTLMLQEEELQDAALLVFANKQDQALSASEVSKELNLVELKDRSWSIVASSAIKGEGITEGLDWLIDVIKE.............................................................................................................................. 180
40 -13.400[K] KOG1534 Putative transcription factor FET5  ali follow..  12  6..........AFVCGVASSGKSTFCGALVGRSCHLVNLDPAAENDWLNEEIGDYDEDYLIFDMPGIELYTHVPILPALIRHLQVTLNFRPCAVYLLESQFLVDRTKFFMSAMVMMEVPHINLLSKMDLLKDNHELNRCIVQLIDDFNMVNFLPLESGNEESVSRVLSYIDDATQWYEDQEPKDPDRFEADDLEDDE......................................................................................................... 276
41 -13.400[U] KOG0077 Vesicle coat complex COPII, GTPase subunit SAR1  ali follow..  16  19......KEAKILFLGLDNAGKTTLLHMLKDERLVQHQPTQHPTSEEL----SIGKIKFKAFDLGG---------HQIARRVWKDYYAKVDAVVYLVDAYDKERFAEALLSDEALATVPFLILGNKIDIAASEDELRYHLGLTNFTTGKGEVFMCSIVRKMGYGEGFKWLSQYI................................................................................................................................ 192
42 -13.400[J] KOG0462 Elongation factor-type GTP-binding protein  ali follow..  17  45..........FGIVAHVDHGKSTLADRLLEMCGAVPPGQKQML-ERERGILRHRGYLLNLIDTPG---------HVDFSAEVSRSLAVCDGILLLVAANQVQAQTIANFWLAFEKNIQIIPVINKIDLPGADIKSVETQLKNLFEFNPEECLHISAKSGLNVDKVLEAIIDRVP------APTAIIDAPFRSMIFDSYFDHFRGAIAHIMVKEGSVKIQSYQNEKVYDVSEVGVMRPEMVKCTELRAGQVGYLVCNMRTVNEAVVGETLFAEVYAGLFPVETSDYESLKQAVERLCLNDP. 355
43 -13.300[J] COG5257 Translation initiation factor 2, gamma subunit (eIF-2gamma; GTPase)  ali follow..  22  9..........IGLVGHVDHGKTTLTKALSGVWTDTHSEETKRGISIRLGYATELLRKVSFVDAPG---------HETLMATMLSGAALMDGAILVIAANEPQPQTKEHLMALDVIGVKVIVVQNKIDIVSKERALESYREIKETCAEDAPIIPVSAQQGANIDILIETIEERIK............................................................................................................................... 198
44 -13.300[P] COG2895 GTPases - Sulfate adenylate transferase subunit 1  ali follow..  16  30..........FLTCGSVDDGKSTLIGRLLHDTRQIYEDQLSSLHEREQGIFSTEKRKFIIADTPG---------HEQYTRNMATGASTCELAILLIDARKGVLDQTRRHSFISTL-KHLVVAINKMDLVDYSEETFTRIREDYLTFLDIRFVPLSALEGDNVASQSESM--------PWYSGPTLLEVLETVEIQRVVDAQPMRFPVQYVNRPNLDFRGYAGTLASGRVEVGQRVKVLPSGVE--------SNVARIVTFDGDREEAFAGEAITLVL........................ 312
45 -12.900[J] COG5256 Translation elongation factor EF-1alpha (GTPase)  ali follow..  16  13..........LITIGHVDHGKSTLVGRLLYEHGEIPAHIIEEYRERERGVFETDKYYFTLIDAPG---------HRDFVKNMITGTSQADAAILVISAREGEGVMEQTREHAFLARPQMVVAINKMDATSPPNEVKADAEKLLRSIGFKDIVPISGYKGDNVTKPSPNM--------PWYKGPTLLQALDAFKVPEKPINKPLRIPVEDVYSITGIGTVPVGRVETGVLKPGDKVIFLPADKQG--------DVKSIEMHHEPLQQAEPGDNIGFNV........................ 296
46 -12.900[J] COG0050 GTPases - translation elongation factors  ali follow..  13  15..........VGTIGHVDHGKTTLTAAITTGSARAFDQIDNAPEEKARGIYDTPARHYAHVDCPG---------HADYVKNMITGAAQMDGAILVVAATDQTREHILLGRQVG---PYIIVFMNKCDMVDDEELLELVEMEVRELLS-DDLPVVRGSALKALEGEAEWEAKIIELAGYL-EPERAIDKPFLLPIEDVFSISGRGTVVTGRVERGIVKVGEEVEIVGIKDTVKSTCTGVEMFRKLLDEGRAGENVGLLRGIKREDIER.................................. 289
47 -12.800[J] KOG0052 Translation elongation factor EF-1 alpha/Tu  ali follow..  17  1MGKEKVHINIV-VIGHVDSGKSTTTGHLIYKKYAWVLDKLKAERERGITIFETAKYYITIIDAPG---------HRDFIKNMITGTSQADCAVLVVACGTQTREHALLAQTL----KQLIVACNKMDSTE-TNEVSGFIKKIGYNPKAVPFVPISGFNGDNMLEVSSNMKTLLEALDSIIPPQRPTDRPLRLPLQDVYKETGIIKPGMVVPQNVTTEVKSVEMHHESLPEAVPGFNVKNVSVKDI---RRGSVCSDSKQDPAKEARTFHAQVIIMNHPGQISNGYT............... 358
48 -12.800[U] KOG3887 Predicted small GTPase involved in nuclear protein import  ali follow..  12  65..........ILLMGLRRSGKSSIQKVVFHKMSP-TLFLESTNKICREDVSNSSFVNFQIWDFPGQIDFFDPTFDY------EMIFRGTGALIFVIDSQDDYMEALARLHLTVNTDINFEVFIHKVDGLSDDHKIETQRDIHQRANDDLASFYLTSIYDHSIFEAFSKVVQKL------IPQLPTLENLLNIFISNSGIEKAF.................................................................................................. 261
49 -12.800[R] KOG0395 Ras-related GTPase  ali follow..  19  22..........MVVLGASRVGKSSIVSRFLNGRFEDQYTPTIEDFHRKVYNIRGDMYQLDILDTSG--NHPFPAMRRLSILTG-----DVFILVFSLDNRESFDEVKRLQKQILEVELPMVICGNKNDHGELCRQVTTEAELLVSGDENCAYFEVSAKKNTNVDEMFYVLFSMA................................................................................................................................ 190
50 -12.600[J] COG4108 Peptide chain release factor RF-3  ali follow..  14  8YFGEVSKRRTFAIISHPDAGKTTITEKVLGSNQHAKSDWMEMEKERGISVTTSGDCLVNLLDTPG---------HEDFSEDTYRTLTAVDSCLMVIDAAKGVERTRKLMEVTRLRDTPIVTFMNKLD--REIRDPMELMDEVENELK-IACSPITWPIGCGKE--FKGVYHIHRDETILYTSGQGHTIQEERIIKGLDNPELDQAVGADL-------AAQLREELELVLGASHEFDRELFLQGELTPVFFGTALGNFGVDHMLD..................................... 272
51 -12.600[R] KOG1491 Predicted GTP-binding protein (ODN superfamily)  ali follow..  13  23..........AGIVGLANVGKSTFFQAITRCPLGNPANYPFATIDPEEARVIVPSAHLTVYDIAGLTKGASA--GEGLGNAFLSHIRSVDSIYQVVRCFDDAEIIHVEGDVDPVRDLEIILRLKDIEFAQKA---LEGAEKIAKRGGQSLEVKQKKEEMDLITKIIKLLESGQRVANHSWTSKEV----------EIINSMFLLTAKPCIYLINLSERDYIRKKNKHLLRIKEWVDKYSPGDLIIPFVSLEERLSHMSPEDAEEELKKLQTISALPKIITT.................... 300
52 -12.500[J] COG3276 Selenocysteine-specific translation elongation factor  ali follow..  13  2.........IIVTSGHVDHGKTALLKALTGTSTAHLPEEKKRGMTIDLGYLPLENKVLGFIDVPG---------HEKFLSNMLAGLGGVHYAMLIVAADEQTKEHLAILRQLQFHE---IVVITKADRTNSAESLIQTIKQDYSFLRNANYFVTSAETGQGISELRHYLANLAELADTQKPFRYAIDRV-TVVTGTAFSGTVKVNDEIYLSTGQKIRIKAIHAQNTSSEQGIA--LDRTPMKRGDWLLQNEPLPPTDRISVQILAEVPLNESQPVHIYHGASR.................. 287
53 -12.400[J] KOG0458 Elongation factor 1 alpha  ali follow..  20  170..........FVVLGHVDAGKSTLMGRLLYDLNIVNQSQLRTNEERERGVFSTHRANFTIVDAPG---------HRDFVPNAIMGISQADMAILCVDCSTQTKEHMLLASSL----HNLIIAMNKMDNVD-KSKLLPYLVDIGFFEDNINWVPISGFSGEGVPNLMSTL-ENAAFKISKENEGINKDDPFLFSVLEIIPESGSIQPGESLPSEQSCIVDKIQVGSQQGQSTNHEETDVAIKGDFVTL-QNGDLAASVDYSSIHSAQCFVLELTTFDMNRPLLPGTP............... 524
54 -12.200[R] KOG1533 Predicted GTPase  ali follow..  13  36..........VLVIGAPGAGKSTFCAGLTKRPFLTINLDPGANCNWLLQKIEANHKKYLIIDCPGKSEGELWKVIRFLEKSGVRL-----CALHLADSLYCSDPSKFILATMVTMEMPQVNCLSKADLFSEDRKLNEAICGVISDFDLVSFVPLAVENKESMMKVIQMVDAANGFSLTEQGDIRELILNSK.............................................................................................................. 299
55 -11.900[R] COG5258 GTPase  ali follow..  12  110..........VVALGNVDAGKSTLVGVLTTARSYASRYKHEVLTGRTSAVYKRSDKLVLLVDVGGHERYLRTALRGLFSSQP-------DYVMLVVAANSGQKMTKEHLGIAVAIGIPVFVVVTRIDITPSEQKTVEEVVRILKMPGVSKVFYVSSVTGHGLDLLLRFLSLLPRRRRWDYGGEFLMYISDIYLVKGVGVVIGGLVEKGILHVGDRVWLGPYSDGKWMQTVVKS-IHFNRTPVESAKAGSFTVALDKVEKVEKGMV.................................... 420
56 -11.600[J] KOG0459 Polypeptide release factor 3  ali follow..  15  104..........VVFIGHVDAGKSTIGGQILFLSGQVDDRQIQNEEERLKGKFETESTRFTILDAPG---------HKSYVPNMISGASQADIGVLVISARKQTREHVQLAKTL----SKLIVVVNKMDDPTVNDEIEQKMVPFLKASGYNVFLPISGLMGKNMDQRMGQEICPWWSGPSFFEPPRDPNGPFRMPIIDKFKDMGTVVMGK-MPNKEQVKVVAIYCDEDKVKRAGPRVRITGIEDEDILSG..................................................... 406
57 -11.500[J] KOG0460 Mitochondrial translation elongation factor Tu  ali follow..  15  56..........IGTIGHVDHGKTTLTAAITKASFMDYSQIDKAPEEKARGIYETANRHYAHVDCPG---------HADYIKNMITGAATMDGAIIVVSATDQTREHLLLARQV----KQIVVYINKVDMVEPDELVEMEMRELLSEYGFDNTPIVSGSALCALEGR----------------EPEIGLNSITKLMEAV--DSYITLPERKTDVPFLMAIEDVFSISGRGTVVTGRVETLKKGAEIEIVGYGSHTVTGIEMFKKQLDAAVAGDNCGLLL........................ 321
58 -11.400[J] KOG0469 Elongation factor 2  ali follow..  19  12LMDRKRNIRNMSVIAHVDHGKSTLTDSLVSKAGIIAGSKAGETREQERCITKYNGFLINLIDSPG---------HVDFSSEVTAALRVTDGALVVVDCVSGVCQTETVLRQAIAERIKPVLFMNKMDRA............................................................................................................................................................................ 175
59 -11.400[U] KOG0092 GTPase Rab5/YPT51 and related small G protein superfamily GTPases  ali follow..  19  23..........LVLLGESAVGKSSLVLRFVKGQFHEFQESTIGAAFLTQTVLDDTTVKFEIWDTAG---------QERYHSLAPMYYRGAQAAIVVYDITNEESFARA-LQRQASPNIVIALSGNKADLANKRAVDFQEAQSYADDNSLL-FMETSAKTSMNVNEIFMAIAKKLPK.............................................................................................................................. 183
60 -11.400[J] KOG0468 U5 snRNP-specific protein  ali follow..  16  124LMDTPPLIRNVALVGHLHHGKTTFVDCLIRQTHPQFEERGCSIKATPVTLVKQKSYLLNIFDTPG---------HVNFSDEATAAMRMSDGVVLFIDAAEGVMNTERLLKHAVQERQAITVCINKIDRL............................................................................................................................................................................ 265
61 -11.400[U] KOG0094 GTPase Rab6/YPT6/Ryh1, small G protein superfamily  ali follow..  15  1MASVSPLAKYLVFLGDQSVGKTSIITRFMYDKFDTTYQATIGIDFLSKTMLEDRTVRLQLWDTAG---------QERFRSLIPSYIRDSSVAVVVYDVANRLSFLNT-VRNERAGDVIIVLVGNKTDLVEKRQVSIEEGDSKGREYGVM-FIETSAKAGFNIKPLFRKIAAALPG.............................................................................................................................. 172
62 -11.300[R] KOG0394 Ras-related GTPase  ali follow..  15  1MPSRRRTLLKVIILGDSGVGKTSLMNQYVNKKFSNQYKATIGADFLTKEVFEDRLFTLQIWDTAG---------QERFQSLGVAFYRGADCCVLVYDVNSWREEFLIQASPSDPENFPFVLIGNKVDVDDGNSRVVSEAKAWCASKGNIPYFETSAKVGTNVEEAFQCIAKDA................................................................................................................................ 176
63 -11.300[T] COG1217 Predicted membrane GTPase involved in stress response  ali follow..  18  8..........IAIIAHVDHGKTTLVDKLLKLSGTLDRKEAESEREKERGIIKWNGYNINIVDTPG-HADFGGEVER--------VMSMVDSVLLVVDAQDGPPQTRFVTQKAFKAGLRPIVVVNKIDR--PGARPDWVIDQIFDLFDNLGATDEQLDFPIVYASALNGIAGLDHEKMDDNMDALFQAIIDHVPAPVVDTEGPFQMQISQLDYNSFLGVIGIGRITRGKVKSNTPVVAISDDGS.......................................................... 245
64 -11.200[E] COG1703 Putative periplasmic protein kinase ArgK and related GTPases of G3E family  ali follow..  11  47IMPYCGNTLRLGVTGTPGAGKSTFLEAFGGLKVAVIAVDPSSSSGHLGGASQRARELMLLCEAAGYDVVIVETVGVGQSETEVARMVDCFISLQIAGGGDDLQGIKKGLMEVAD-----LIVINKDDGDNHTNVAIARHMYESALHILRRVLTCSALEKRGIDEIWHAIIDFKTALTASGRLQQVRQQQSVEWLRKQTEEEVLNHLFANE........................................................................................... 294
65 -11.100[R] KOG0088 GTPase Rab21, small G protein superfamily  ali follow..  15  15..........IVLLGEGCVGKSSLVLRFVENKFSCKHLSTIQASFQNKTVVEDCQADLHIWDTAG---------QEKYHALGPIYYRGSNGVLLVFDITDRKSFEKV-IKTCLGNTAEILIVGNKIDLEEERQVTRQDAEAYAESEGAL-YMETSAQDNVGISDAFESLTAKMIE.............................................................................................................................. 175
66 -11.100[R] KOG1424 Predicted GTP-binding protein MMR1  ali follow..  14  389..........VGLVGYPNVGKSSTINTIMGNKKVSVSATPGHTKH-FQTLYVEP--GLCLCDCPGL---------------PSFVSTKAEMTC-ILPIDQMRDHVPPVSLVCQNIPRHVLEATYGINIITPREDSEELLTAYGYMRGF-----MTAHGQPDQPRSARYILKDYVSGPPGRDPVTFQHQHQRLLENKMNSDEI-GRNKKAKQIENIVDKTFFHQENVRALTKGVQAVMGYKPGSGVVTASTASSENGAGKPWKKHGNR---RRLYKHLDM...................... 658
67 -11.000[U] KOG0095 GTPase Rab30, small G protein superfamily  ali follow..  15  1MSMEDYDFLFIVLIGNAGVGKTCLVRRFTQGLFPPGQGATIGVGFMIKTVINGEKVKLQIWDTAG---------QERFRSITQSYYRSANALILTYDITCEESFRCL-IEQYASNKVITVLVGNKIDLAERREVSQQRAEEFSEAQDMY-YLETSAKESDNVEKLFLDLACRLIS.............................................................................................................................. 172
68 -11.000[U] KOG0086 GTPase Rab4, small G protein superfamily  ali follow..  17  1MAETYDFLFKFLVIGSAGTGKSCLLHQFIENKFKQDSNHTIGVEFGSRVVVGGKTVKLQIWDTAG---------QERFRSVTRSYYRGAAGALLVYDITSRETYNSL-ARTLASPNIVVILCGNKKDLDPEREVTFLEASRFAQENELM-FLETSALTGENVEEAFLKCARTI................................................................................................................................ 169
69 -11.000[T] KOG4252 GTP-binding protein  ali follow..  15  1MLEEDMEVAIMVVVGNGAVGKSSMIQRYCKGIFTKDYKKTIGVDFLERQIVNDEDVRLMLWDTAG---------QEEFDAITKAYYRGAQACVLVFSTTDRGSFEAV-REKVVAGDIPTVLVQNKIDLLDDSCIKNEEAEALAKRLRLR-FYRTSVKEDLNVNEVFKYLAEKY................................................................................................................................ 169
70 -11.000[R] KOG1673 Ras GTPases  ali follow..  14  104..........ISLLGDCQTGKTTFVVKYVGDENQSFLEMTGLNLMDKTFYVQGVTISFSIWDVGG---------EKRSKDHIPIACKDAVAILFMFDLTSRSTLNSV-YSQARKWNKTAIPILTKFDDFVRLPPNLQWTIVTQARAYAKVLFFSSATHNINVNKIFKFILARL................................................................................................................................ 266
71 -11.000[R] COG1161 Predicted GTPases  ali follow..  17  179......RGRDVYVVGVTNVGKSTLINAIIKSAVITTSRFPGTTLDKIE------DEDSALIDTPGIIHRGKYVSPRKEIKPKTYQLDPEQTLFFLARFDFISGERQGMTAYFDNEINVHRTKLEGATEFYEKHKGELLAPALVGAKLVRREFKITDKSDIVFSGL-AVVAAWVPEGVDVVVRKALIG.................................................................................................................. 381
72 -10.900[TU] KOG0084 GTPase Rab1/YPT1, small G protein superfamily, and related GTP-binding proteins  ali follow..  16  1MNPEYDYLFKLLLIGDSGVGKSCLLLRFADDSYLDSYISTIGVDFKIRTVQDGKTIKLQIWDTAG---------QERFRTITSSYYRGAHGIIVTYDVTDLESFNNV-IDRYASENVNKLLVGNKCDLTSQKVVSTETAKAFADELGIP-FLETSAKNATNVEEAFMAMTAAI................................................................................................................................ 169
73 -10.900[H] COG3172 Predicted ATPase/kinase involved in NAD metabolism  ali follow..  15  11..........VAILGGESSGKSTLVNKLANI----TTSAWEYGRDYVFSHLGGDEIALQYSDYDKIALGHAQYIDFAVKYANKVAFIDTDFVTTQAFCKKYEGREHPFVQALIDEYRFDLVILRSLGSSVDRKEFQNLLVEMLEENNIEFVRVEEEDYDSRFLRCVELVREMMGE.............................................................................................................................. 185
74 -10.800[U] KOG0096 GTPase Ran/TC4/GSP1 (nuclear protein transport pathway), small G protein superfamily  ali follow..  16  15..........LVLVGDGGTGKTTFVKRHLTGEFEKKYIATIGVEVHPLSFTNFGEIKFDVWDTAG---------QEKFGGLRDGYYINAQCAIIMFDVTSRITYKNV-HRDLVRVNIPIVLCGNKVDVKERKVKAKTITFHRKKNLQY---YDISAKSNYNFEKPFLWLARKL................................................................................................................................ 170
75 -10.800[DZ] COG5019 Septin family protein  ali follow..  16  85WHRRCVRQGFVLVLGESGSGKSTLVNTLLNRDVDFGVNPEPTVMINSSAVEIVENGQLNVIDTPGFNTDCWQPVLTDIEGRYDQYLELVHACIFFIQPTGHAAMELRVMLALHE-KVNIIPIIAKADTLTDDELNFTKEMILRDIQYHNIRIFFPPTYETDDPESVAENADIMSRIPFAYPWGVVEVDNEEHSDFPKLREMLIRTHLEELKEQTNKLYEAYRTERLLSSGISQDHSVFREVNPSAKLEEERALHEEKLMKMEAEMKTIFSQKVQEK-----EDRLKQSENELRT....... 428

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Ye Y, Godzik A. Comparative analysis of protein domain organization. Genome Res. 2004 Mar;14(3):343-53.