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Query: [K] COG2345 Predicted transcriptional regulator, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MGDVVKGNDAHTGDGDTRRKILLILLERAPVIASDIAEQLQLSTVGVRRHLDNLVEENLAEAANPRQNPYEPKMRGRPAKTYRLTDKGRSIFGHEYDSLAAAALATLREVGGDDAVRQFARKRIETIVEGITPADVTDQSIEDTAKSLVEAFSRHGYAATVDATRNGLQLCQHHCPISTVATEFPELCEAEHQAVSELLGQHTQPLATIADGHGICTTNIPLTPIKHSLast
1 -96.800[K] COG2345 Predicted transcriptional regulator  ali  100  1MGDVVKGNDAHTGDGDTRRKILLILLERAPVIASDIAEQLQLSTVGVRRHLDNLVEENLAEAANPRQNPYEPKMRGRPAKTYRLTDKGRSIFGHEYDSLAAAALATLREVGGDDAVRQFARKRIETIVEGITPADVTDQSIEDTAKSLVEAFSRHGYAATVDATRNGLQLCQHHCPISTVATEFPELCEAEHQAVSELLGQHTQPLATIADGHGICTTNIPLTPIKHS 228
2 -23.300[K] COG1777 Predicted transcriptional regulators  ali follow..  18  1MIDDID-NFIAAIENSTRREIIRMLTQFERSYALELSRSIGLSQQAILKQLEMLERANLVTSIGF-----VPSSVGAKRKLYEPTGFSTLIVDYGRNFLMIQRIPLENDSERVSVSFDEAISKLESIQHHIEELTKKRTELVKKKDELMAAIKY.......................................................................... 148
3 -19.700[K] COG4190 Predicted transcriptional regulator  ali follow..  11  58....TSYDDLMDTLTPRVLELIEAIRQEEPASINETARVVDRDVKNVHEELSRLAHLGIIFFEEDGQ................................................................................................................................................................. 120
4 -19.100[S] COG3398 Uncharacterized protein conserved in archaea  ali follow..  14  99....RITERADVFENSNRARIYEYIKTRPGAYLSEIIEKAGIDRGAARYHIKILKAHHKIEAYRE----------SGKTRYFQNNST--------YGEEEKKVVSALQNATNQRIISEIQNGKCNTNLALAREIGVSRATISWYVKNLKETETRSGRSIIYSINPSYEPLIEK....................................................... 253
5 -18.700[K] COG1497 Predicted transcriptional regulator  ali follow..  16  2.......KALRKKGELTRFQILSEIMRQPYVRQKDIADKLGVTVQAVSENIKSLIAEGLVESGSGR-------------SHYKITRRGAEKIKEAAMDLRRYADEVLESMSFYRSVWPAIAWEDLQEGDKVELFMEDGRRRNGEAYAEVLHPARRGEDVALSELGGTIPLQRGKVTIAVLPG.............................................. 169
6 -18.300[K] COG3355 Predicted transcriptional regulator  ali follow..  18  26..............SKSDVEVLHILLQNGKMTTDDLSQKLNVTKASISKALNNLLDKGLIQREKAPAEKEER............................................................................................................................................................ 83
7 -17.700[S] COG3388 Uncharacterized protein conserved in archaea  ali follow..  16  18...............KRHISVINVLLREQPIGIIKLSQETGIPEHKIRYSLRILEQENIISPS..................................................................................................................................................................... 65
8 -17.400[S] COG4860 Uncharacterized protein conserved in archaea  ali follow..  23  19..........HAADSEVKRKLLLDL-STGWITLPVIEQKYG---KEGRRALLYLDKIKMIETQWITGQNGPEK........................................................................................................................................................... 77
9 -17.300[S] COG4344 Uncharacterized protein conserved in archaea  ali follow..  11  2..SEYEKEIDELINDYDMLRVLKHFTIAHVDYAKNITRYTEIPQMRVREYLKRLKDLGLLDYKRTEAKLKKSAEVHKHHTYYQINKKAEAVLKEITPKLYVHHLKS.......................................................................................................................... 111
10 -16.900[K] COG1846 Transcriptional regulators  ali follow..  17  41..............TPSEIHTIDAIGTDEGLLMKELAERLGVTKGAVSQLVDRLEAKALVRRTAHPKV--------SRGIQVVLTDKGREAY-RAHADMHAAFYEELQQSFTKEEIAIFEQ........................................................................................................... 138
11 -16.400[K] COG4189 Predicted transcriptional regulator  ali follow..  19  14......FDVLKAAASLIRVQILKLLHEANGLNVNEIAQRLALPQSTVSAGVAVLEEAGLLRTETRKARKGSQ............................................................................................................................................................ 79
12 -15.900[S] COG3373 Uncharacterized protein conserved in archaea  ali follow..  19  1MEPIVDGNILRSLNSELRRKVLFYLLSIYPSYLSEISRAVKSDPSNVKGCLESLIGLGLVIVEQS----------KNGFKYFKINPEIVEEVRN...................................................................................................................................... 97
13 -15.600[K] COG4738 Predicted transcriptional regulator  ali follow..  20  35..............NRPVALTLACLSKGDEISSQRIEMVSGLRQPEVSIAMRYLRENEWVDMREEKKNH----GKGRPVKLYKLTVQMETIIDTIEENVIAES............................................................................................................................. 119
14 -15.600[KH] COG1339 Transcriptional regulator of a riboflavin/FAD biosynthetic operon  ali follow..  10  2..............KMKTLFLLIKLAKMGTVTMRELSRELDVSPQTVLRWLEELKEQGYIHKRESRKG--------TLVELTEKGINLLEKLYEEISTALYSGFIVGEVISGIGEGAYYVRQYAPLIREYLGFDPYPGTRVLFPKTIFDALCTARPIIIPGFTRNGDVRAYRVRIDGIEGAIVIPSRTVHPPKIAEIIAPVKLRDALNLKDGD............... 205
15 -15.500[R] COG1719 Predicted hydrocarbon binding protein (contains V4R domain)  ali follow..  13  19...................................................................................................LFHVLRFGFEAYGIDN-APVVRMIGRDIGKCLSANFES-NTPEALFREIATFMEFHGDCRVSVLMGDSPALQVEDDFKARMPAIGKPLCVLREGILEGVLKEGVLETECYGTGHTRCLFEIT....... 145
16 -15.300[K] COG5625 Predicted transcription regulator containing HTH domain  ali follow..  21  20..............KKNEIRIYRLLEKRRGMRIREIQRELGISERSVRTHVLNLYRRGLLKRELVQSGW............................................................................................................................................................... 75
17 -15.000[S] COG4519 Uncharacterized protein conserved in bacteria  ali follow..  12...................YLALLVESLERPNVPKLIEKTGWPRRTIQDVIKAMPGIGIELNFVQDG................................................................................................................................................................. 59
18 -14.100[K] COG4742 Predicted transcriptional regulator  ali follow..  28  10............FRSQKRRDLLLLLGE-EPRTMEDIKVLLDVSPTAILPQIKRLTDSNLVIQK..................................................................................................................................................................... 59
19 -14.000[K] COG0640 Predicted transcriptional regulators  ali follow..  15  1................................MNEITMQTQADQPKVSSNLAILSEARLVDSIQM----------GR-EKIYRIAPEK-----------FEDMVDWLDSILHSKSSGGSANYGLSPVNDLNYARTCYDHLAGEMGVYLLEELLKRKWIILDDPEKPTYRLTTAG-PRANGKRMFAYGCTVKRFHLGGFLGSSI......................... 163
20 -13.900[KG] COG1349 Transcriptional regulators of sugar metabolism  ali follow..  13  2............KPRQRQAAILEHLQKQGKCSVEELAQYFDTTGTTIRKDLVILENAGTVIRT..................................................................................................................................................................... 52
21 -13.500[K] COG5631 Predicted transcription regulator, contains HTH domain (MarR family)  ali follow..  12  82..............SPIEILILHSIHRDREKKLADICLALDIETHIATYAIRKLEKAGLLTTGKAAK-----------EKTVKITAKGAEACAHYAQIRERLLVDSTANARPSEETLSELAALLRFMSGAFNQATRSAITL....................................................................................... 199
22 -13.400[K] COG1510 Predicted transcriptional regulators  ali follow..  15  30..............PSTVGRVLGII-NRKPMTLSELSEATGMSKTRMSQVVREMIDANIAEKVFEKGVRKD------EQDYYQTFISLFAANWTKVVSKNKVLYKKLNRELSDLLQRDGLTPEAEEKVNQLLNELKEWLHYYDWLSRLIEFFES.......................................................................... 168
23 -13.300[K] COG3432 Predicted transcriptional regulator  ali follow..  18  34...............RGTMEIMFDILREPKCGITRVIYGAGINYVVAQKYLDQLVKVGALNIKTENDR-----------KIYEITEKGKL.......................................................................................................................................... 99
24 -13.300[K] COG1522 Transcriptional regulators  ali follow..  25  7..............DKIDRKILEVLQSNGRLTNLEVAERVNLSPSPCLRRIRRLEESGVIR....................................................................................................................................................................... 53
25 -12.900[K] COG1675 Transcription initiation factor IIE, alpha subunit  ali follow..  18  1MKAETTTGVEELLNELVGRLILFSLGIEGEFTDDQLSLELGIEINEIRKALFALYEIGLADYVRRRDDETGW............................................................................................................................................................ 78
26 -12.500[J] COG4901 Ribosomal protein S25  ali follow..  16  45............LDEKVFQAIAKEVQNMRVITPYEIASKYGIKMSVAFKVLRNLKERGDLV....................................................................................................................................................................... 93
27 -12.400[K] COG1654 Biotin operon repressor  ali follow..  12  4..............TTVPLTLISLLADGEFHSGEQLGERLGMSRAAINKHIQTLRDWGVDVFTVPGKG................................................................................................................................................................ 57
28 -11.700[K] KOG2593 Transcription initiation factor IIE, alpha subunit  ali follow..  14  24.........AKNGSGGIAVLVLDALTRRQWVREEDLAKELKLNTKQLRTILRYFEEQQFIMRVHRKEKSSATTN--------GRGEDKVKVHMYSYCCLDYSQIYDV---------------------------------IRYKLHRMKKEFKD--------VLEDKDNVQEYGCP-----------CKRKIFFHC------ENCNGELVMECNKLTSEEVVVDGSDN 177
29 -11.100[S] COG2512 Uncharacterized membrane-associated protein/domain  ali follow..  16  234.PDIETAALNRIPLSPELCEVLDIIRGHGRITQKDLRSKLDYSEVKVSLMLSELEKRGLIRKLRNGREN............................................................................................................................................................... 302
30 -10.900[K] COG1802 Transcriptional regulators  ali follow..  11  1MLAGMGVIKPETLRYQVRQAIMS-FTPGERLIERELCETLGVSRTSIREALRRLEAEKLVSIVPHKG-----------PIVAIISRQEAAELFALRGLLEGFAAREFAQRATDVAIVHFAQAIQALRMAGMTKDRAKVLKAKTDLYDVLLDNCGNGLVKETLTS----RINLLRATSLMDPQRLPVSINEIDDLYQALKARDPDAAERHVA................. 204
31 -10.800[L] COG3415 Transposase and inactivated derivatives  ali follow..  29..............TRVLQRLYFIRYLYRGMSVEEAAELVGITKATGYTWLKRWNTRGY--EGLIPEFGGGRPSKLTKDQKEELKEMLKERDSWTTKEVQELIEAKFGVSYSSWQVRRILKSFGMKYAKPYQKDYRKPENAEDSLKK................................................................................. 159
32 -10.600[J] KOG1767 40S ribosomal protein S25  ali follow..  16  43............FDQATYDKLLTEAPKFKLITPSILSDRMRINGSLARRAIRELMAKGVIR....................................................................................................................................................................... 91
33 -10.500[S] COG5352 Uncharacterized protein conserved in bacteria  ali follow..  14  4..............TDERVELLRKLWSEG-LSASQIAAQLGVSRNAV---IGKVHRLKLSGRGRATATPARQKKTTQGSTVQKSVARAAS------------------TRHVTTSIGATALQTQFDAEPVARHYIRPVENVVVPISRHLQLVE----------------LTERTCPNGDPLSEDFNFCG-----------------NEAAETGPYCKYHARVAFQPAA 165
34 -10.300[K] KOG3233 RNA polymerase III, subunit C34  ali follow..  10  78...DSQNAGKMKGSDNQEKLVYQIIEDAGGIWSRDIRYKSNLPLTEINKILKNLESKKLIKAVKSVAASKKKPDRSVTGGAWYSDQDFESEFVEVLNQQCFKFLQSKAETARESKQNPMIQRNSSFASSHCELGISKVELSMEDIETILNTLIYDGKVEMTIIAAKEVRAPCGLCPVFDDCHESPSNCIYMTEWLE................................ 315
35 -10.300[K] COG1378 Predicted transcriptional regulators  ali follow..  16  36..............RDYEARVYATLATRGEATASEIHRVSGVPRNKVYEVLRSLEDRGMIETIKSSP------------AVFRAIDPESEEYKEQLVSAVDTAIRSIRESEDFSTLHPV---------------VRGLAGIKNRAKAMLQRSEEV......................................................................... 153
36 -10.200[K] COG1414 Transcriptional regulator  ali follow..  12  1MREPTLETDDRYRAPALDKDILELLSVDGGLTQAEIAKHLDRSPNEFYRMLDRLVKRGYVTKLDGDR--------------YSLTLKQLHAPVRRLASFATPFMRELADRSKQAVLLAFRSPEEREMMIAAHVKSRDEVNLDQDFYDRLDQIRERGYEMMASAQMAG--AYNLSAPILGPDGT---VAALTCPYITLVNPSSAPDITQTISLLQKTVRDLSKL..... 255
37 -10.000[K] COG2378 Predicted transcriptional regulator  ali follow..  15  28...................EIIQILRARRPVTAQTIADMLEVTARSVYRDIAALQTMRVPIEGERGVGYILRPGFNLPPLMFSIEETEA--------VLALAMVDRSGDAELRQAAKKVSDKIAASLPEPLSKTLSAPAPAGIDLATVRRAVRDEERLDLCYSDESGVETQRRIRPIAVIYYSE-AWCELRHAI.................................. 210
38 -9.890[K] COG5340 Predicted transcriptional regulator  ali follow..  14  1MSSTQETQTIRQGLSTRESRLLSHLAAEG-ISIDDVEATLEVAPNTAREIASRLTEKGWLDR...................................................................................................................................................................... 64
39 -9.800[S] COG4754 Uncharacterized conserved protein  ali follow..  10  16...................GLLYVMNNDGKTDLYQLEKEMEVDIDDLMPIVYTASRLGFVSAESGD---------------IIVTEEGKEYIRASIKRRKEIIREALRNIEPFRTALDLRNFDCETLMENLQRKGVQTFNSPSGKHDLEVILIEWGYSGLLRKDDDGFSV.......................................................... 154
40 -9.780[K] COG2186 Transcriptional regulators  ali follow..  17  1MNGQAKIAEPRRLYQQIADQIRELIDVGE--AERELAQKLGVSRPSLREALIALEIDNTVEIR..................................................................................................................................................................... 69
41 -9.730[R] COG2522 Predicted transcriptional regulator  ali follow..  19  19...............SIRASIAKILVEEYKMSKYSVAKMLGATPTAVSYYISGKRGEKFVD....................................................................................................................................................................... 64
42 -9.700[KT] COG1974 SOS-response transcriptional repressors (RecA-mediated autopeptidases)  ali follow..  12  5..............TEAQQELYEWLAEY-SPSIRQMMQAMNLSPAPIQSRLEHLRTKGYIEWTEGKART............................................................................................................................................................... 65
43 -9.520[K] COG1695 Predicted transcriptional regulators  ali follow..  16  2..............DRYAIKALVLLSKKLYQMSKEISTGVQVSHGTLMPMIRKLLQERYIDFETRGR-----------EKVYHLTERGSRFVESLGKIE................................................................................................................................. 78
44 -9.480[DR] COG5124 Protein predicted to be involved in meiotic recombination  ali follow..  9..............DQKKSILLEIIRGSKSFELESLGSKKGIVVNTIKEILQQLVDDGLVTAE----------KVGTSNLYWSFASEGIQKKKLRCKELMEEC-ERMSQDICRKREYIENEKMSKHYTEERNELENKLNALMKIEQDQREELGKFE........................................................................ 143
45 -9.480[DR] KOG3433 Protein involved in meiotic recombination/predicted coiled-coil protein  ali follow..  9..............DQKKSILLEIIRGSKSFELESLGSKKGIVVNTIKEILQQLVDDGLVTAE----------KVGTSNLYWSFASEGIQKKKLRCKELMEEC-ERMSQDICRKREYIENEKMSKHYTEERNELENKLNALMKIEQDQREELGKFE........................................................................ 143
46 -9.450[K] COG1725 Predicted transcriptional regulators  ali follow..  3PTFHADKPIYSQISDWMKKQMITGEWKGEDKSVREMGVKLAVNPNTVSRAYQELERAGYIYAK..................................................................................................................................................................... 67
47 -9.420[K] COG5111 DNA-directed RNA polymerase III, subunit C34  ali follow..  10  73...RLDEAKTVSTMEGDEQIVYSFIKNSGGIWRKTLTLRTNLHVSVVDRCLKSLESKNLVKSIKSVKNPTRKPSTELTGGPWFTDQELDVEFIENLKKVIYRYVHSKSFPPKKAAMGPDLVWGPEYNGYPTALQITNITKVDLSLANVISLVDVLIYDGKVEKRSDGTESPCGNCPVSDICDANPITCEYLDKWLN................................ 301
48 -9.410[T] KOG4603 TBP-1 interacting protein  ali follow..  11  1MSKGRAEAA-----AGAAGILLRYLQEQNPYSSQDVFGNLGLGKAVVVKTLEQLAQQGKIKEKM-----------GKQKIYFADQDQFDMVSDADLQVLDGKIVALTAKVQSLQQSCRYMEAELKELSSALTTPQKEIQELKKECAGYRERLKNIKAATNHVTPEEKEQVYRERQKYCKEWRKRKRMAT---ELSDAILEGYPKSKKQFFE................. 200
49 -9.320[K] COG3888 Predicted transcriptional regulator  ali follow..  20  2...............SLRDVLLRELKRARGIDQFQIEEMMGFSKSTVSEALKDLEEKGIIKRR..................................................................................................................................................................... 51
50 -9.290[K] KOG2587 RNA polymerase III (C) subunit  ali follow..  385..............GKEAFRMFRYLSQEGRVETDKIADAALTEKKDTPQFLLKMWKDGYLHMQKLAVTA---PGMYTPFLLWKVNLIVTTQMLDEMYHASLNLSLRLAHE--LEAEKELLLLPLDKLEGPLKERLKKVKAKRLLLSSTMFKLDD.......................................................................... 521
51 -9.190[L] COG3335 Transposase and inactivated derivatives  ali follow..  12  12LSEDEQTQLAGMVRSRSRARLV--LAAAAGEPNSEIAERLQLTRATVGKWRARFLERRI--NGLYDELRPGKPRTIDDERVAELIKTTLHTKPADGSTHWSVRAVAAETSISPTSVHRYFKLLGLQPHRSETFKLSTDAFFIEKLRDVVGLYLN.......................................................................... 168
52 -9.120[K] COG3682 Predicted transcriptional regulator  ali follow..  10  4..............TAAEAHVMEALWRRSPLSADELVAEVSWGEATVKTLINRLLKKKAIKSERAEGKHGYRPLVDRSAYVQAESQG-DRLFDGQLAPLISHFAQH.......................................................................................................................... 100
53 -9.070[K] COG1321 Mn-dependent transcriptional regulator  ali follow..  19  1.........MVLMHTDRIEEYLETIKNQGPAKTKQIAEELNVSSPSVTEMIKKLHSMGFVEYKPYQ.................................................................................................................................................................. 62
54 -9.060[K] COG3327 Phenylacetic acid-responsive transcriptional repressor  ali follow..  12  1MSKLDTFIQHAVNAVPVSGTSLDSLSHRGGGSLAALLEGLGFGERFVRTALFRLNKEGWLDVSRIGR-----------RSFYSLSDKGLRLTRRAESKIYRLLLSEGLDKSTLADVKKQLIWQGFGALAP---------SPSQKLADVQTLLHEAGVADNVLSRAALRARVEECWHLTEQNAMYETFIQSFRPLVPLL.............................. 213
55 -9.030[S] COG2469 Uncharacterized conserved protein  ali follow..  21  198..............SEVEEQILTMVYT--GVDSVSVESILGVTTEELNKMYDRLVNLGLARVV-------------KIRKEIELTPRGVALVSEIMKKAA................................................................................................................................ 268

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Grynberg M, Topczewski J, Godzik A., Paszewski A. The Aspergillus nidulans cysA gene encodes a novel type of serine O-acetyltransferase which is homologous to homoserine O-acetyltransferases. Microbiology. 2000 Oct;146 ( Pt 10):2695-703.