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Query: [S] COG4938 Uncharacterized conserved protein, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MINEVTLRNFKCYKNQLFELANLTVFCGNNSSGKSTVIQSLLLILQNNFSNKLELRGDYVQPGSYNDLHNRNADEDSLSILIDTSVGAVSWGYSEDEFSSQKRKEVEEAPLPLLDFSDKTVLHKLRELYEDEFIYLHAERWGPRSSYPYSTRRRSQNWLGTNGEYAPQVLELVVKNIQTMPSDDVRIHPNLTDGSVVGIAQNLFEWMGEISPGVFIKAQAFKHADITTNQYTFGGESYRAVNVGFGLSYVLPIVLALLVTKPGGLVIIENPEAHLHPRGQSYLGRLIALAAEAGVQVVVETHSDHIINGIRLMPRLGKVQDKNLLFYQVINEDVGTTTVKKIIVNAQGQFSEWPDGFFDQQVLDMQVLMTGQDKLast
1 -94.600[S] COG4938 Uncharacterized conserved protein  ali  100  1MINEVTLRNFKCYKNQLFELANLTVFCGNNSSGKSTVIQSLLLILQNNFSNKLELRGDYVQPGSYNDLHNRNADEDSLSILIDTSVGAVSWGYSEDEFSSQKRKEVEEAPLPLLDFSDKTVLHKLRELYEDEFIYLHAERWGPRSSYPYSTRRRSQNWLGTNGEYAPQVLELVVKNIQTMPSDDVRIHPNLTDGSVVGIAQNLFEWMGEISPGVFIKAQAFKHADITTNQYTFGGESYRAVNVGFGLSYVLPIVLALLVTKPGGLVIIENPEAHLHPRGQSYLGRLIALAAEAGVQVVVETHSDHIINGIRLMPRLGKVQDKNLLFYQVINEDVGTTTVKKIIVNAQGQFSEWPDGFFDQQVLDMQVLMTGQDK 374
2 -38.700[R] COG4637 Predicted ATPase  ali follow..  13  8QLSRIVLKGFKSIAKCDLEISRVNILIGANGAGKSNFIGFFRMVGQLVEENLQVFVSRQGSPDALLHFGRKTTEHLEFQLYFGNNGYFATLEPTQDNRLMFARESFWWNMSGEHEIGRGHFETKVLTSTRTGIDEYVLSAMQQWRVYHFHDTSESAYIKQPHGINDNAYLRPDARNL--------ASFLYLLRNSYPASYQRIVKTIRLVAPFFG-PAPQNKEVIELEWFERGQDIPFKAYLLSDGTLRFMCLATVFLQDLQPETILVDEPELGLHPYAITVLASLM---RTASKQVIVSTQSIELL---------NQFEAKDVIVV---DRSEGSSYLRRLNQGDRIHFTGY..................... 343
3 -31.300[L] COG3593 Predicted ATP-dependent endonuclease of the OLD family  ali follow..  1MLRQLDVLGFRGIHRLSIHFSADMVLIGENMWGKSSLLSALSLIFNPEKALYQFTLRDFHIPAEQTEPVRHLILLFTFAESEKNEDSMEYHLPYLQHHLLVDHLDGYQRLYLRVEGQINANNEVNTTYAFLNEKGEPIVVDDINNLVFSLIAR--------------HPVYRFRDARLNRAHHSFRFIRTEVQDETQDEIRAVSDLLCYYFLNHKNMTEIKQDTTLLWHKAKSLCTKLKQDETHRLRKKLFFSLASLFVRFTRPIILFEDPDARLHPRMVAIMWELV---SYLPVQRITTTNSVELL---------SQVNLNAICRLVRTPEKINCFQLRRKDLGKE-RLTFHSLALFSRMW-----LVEGESE 360
4 -28.600[R] COG3950 Predicted ATP-binding protein involved in virulence  ali follow..  12  64.LRNISLYDYKKFSKLKFTSKNTTIIIGNNGSGKSTILESISKCLQFLSDNIRIQNNNNYKFQDSEINIHSISGQTIVRCILEIENDFSFSCSLTKNRENISRKVSSELEEFKALARMYQRSNELDNNTLS-NDFFSWYKEIDDIINEFKANDSITKEEIEYLLSKTDNKEKIGSLISQLLEKKNNYNNNEDREFLIRQQKVIQESIKTFVS--DIDQVKISRTPHLDMTVIKNGSEISIFNLSQGEKTLIALVSDIARLNGYGIVLIDEIDLHLHPKWQQTIVQKLENT--PNIQFILSTHSPLVLTTVTSQIKIINELDYRFKLLSPTSNPFGKNASDALAIMETSESPLVHSEEILALIKKYESLVKRGQ. 494
5 -21.400[R] COG1106 Predicted ATPases  ali follow..  1MLLQFYFSNYRSFEDENEKVLPVTAIYGANASGKSSVFEAFQFMALCVLESLSFSDDNKKNPYKLK---ESKEKPSEFEINYIDKKGKKELYYNYGFKIDNSGILEEYLASNTKTGVKRNEDYTYIFKRERNQKLYLDSSIEKFRENLEISLKEKTLLVSLGAKLNIDEFIRVRTFSNSLYGALLENILPNNIIESEEVRKNLVSFINSFDDSIINDKDNYRVFTIHKSDKGTSTARISMNEESSGTKKMFSLYQTLLDVEKGGVFFADELDIKLHSLLMRNILLTFTDKNPNNAQLIFTTHNTIYMD-------MDLLRRDEI---WFVEKDNGVSNLYSLD---LGNYGAIP.................... 411
6 -17.700[R] COG3910 Predicted ATPase  ali follow..  16  1MLDSVAMKEMRHLERLEFK-TPITFFAGNNGSGKSTLLEGLAAGMTAYAIGNHG-------------------------------------------------------------------DVKGDLYLQHAETVAKAFYFARKKYPKIRMFLRAEDVLGYIRRQNENALDDFRWEREKALKKGEDFPEETPEIFRGIVRNN------------------------------------SLDRRSHGEGF---LDIMHRRLHGAGLYFLDEPESPLSPQKQLELAAIIRQAADSGGQLIIATHSPVLLAIPEATIY--YFDEDGIT-------ERLYDELENIAFLR--RFLDRPSKYLDD.............. 258
7 -12.400[RK] KOG2355 Predicted ABC-type transport, ATPase component/CCR4 associated factor  ali follow..  12  12..DAIRVSGMFAYEVEDPIFFDFNLLVGANGSGKTTLLKILAGKHMVGGKNVVQVLS-----------------------------------------------------------------------------------------------RSAFHDTQLVCSGDLSYLGGSWSKTVGSAGEVPLQGDFSAEHMIFGVEGTDPVRREKLIDLLDINLQW------------------RMHKVSDGQKRRVQICMGLL--HPFKVLLLDEVTVDLDVVARMDLLEFFKEECDQGATIVYATHLETWATHL-AYIQDGEL....................................................... 227
8 -11.800[EJ] KOG0062 ATPase component of ABC transporters with duplicated ATPase domains/Translation elongation factor EF-3b  ali follow..  12  5..IEIVNTDFLAYGSRML-LNKTNLLCGRNGAGKSTLMRAIA-------------NGQLDGFPDKDTL---------------------------------------------------------------------------------------------------RTCFVEHKLQGEEGDLDLVSFIALDEELQSTSREEIAAALESVG-------------------FDEERRAQTVGSLSGG--WKMKLELARAMLQKADILLLDEPTNHLDVSNVKWLEEYLLEH--TDITSLIVSHDSGFLDTVCTDIIH--YENKKLAYY-------------------KGNLAAFVEQKPEAKSYYTLTDSNAQMR 229
9 -11.500[L] COG0419 ATPase involved in DNA repair  ali follow..  16  558..................................................................................................................................................................................................................................................CSAGQKVLACIIIRLALAENCGILALDEPTTNLDEENICSLAKNLSRIVEANFQLIVITHDEQFIRLVNSDAYCS-------YYYRVKRDTNQKSMVRFANTVI............................ 663
10 -11.100[V] COG1131 ABC-type multidrug transport system, ATPase component  ali follow..  11  1MPSILSISGVKTYATGFTALKEVNLLLGPNGAGKTTLISIVCGIVNRSTGT----------------------------------------------------------------------------------------------------------------------VTVDGHDIGKDYRAARSLIGLVPQELTIDAFESVWATVNYSRGLFGKPPNHGFVEKVLRDLSLWDKKDAKAITLSGGMKRRLMIAKALSHEPR--ILFLDEPTAGVDVELRQDMWEMVRRLREDGVTIILTTHAEAMADRVGV-INRGEIILVENKAELMHKLGRKRLVLE.................................. 233
11 -11.000[D] COG2884 Predicted ATPase involved in cell division  ali follow..  14  7VSKKYKSLARPALDNVNVKIDKFVFLIGPSGSGKSTFMRLLLGAETPTSGDVRVSKFHVNKLPG--------------------------------------------------------------------------------------------RHIPRLRQVIGCVFQDFRLLQQKTVYENVAFALEVIGRRSDAINQVVPDVLETVGLS--------------------GKANRLPDELSGGEQQ---VAIARAFVNRPLVLLADEPTGNLDPDTSKDIMDLLERINRTGTTVLMATHDHHIVDSMRQRVSLGRLVRDE................................................... 220
12 -10.600[P] COG3638 ABC-type phosphate/phosphonate transport system, ATPase component  ali follow..  12  25....LAVKGLKAYKSQHRVLDNINFIIGRSGAGKSTLLHILNGTIPT-SAGEIINYHENGDTQNIAALTTKQMRKWRAKCGMIFQDFCLVPRLDV-------------------------------------------------------------------------------TNVLLGRLSYTSTLKSFFKLFSEQDQARAIELLQWLNML--------------------PHALQRAENLSGGQMQ---VAICRAMMQNPKILLADEPVASLDPKNTTRIMNTLQKISENDIAVIVNLHSVDLVKDYCTRVAHGRIIFD.................................................... 254
13 -10.500[O] COG0396 ABC-type transport system involved in Fe-S cluster assembly, ATPase component  ali follow..  11  7LHARIVDDGTEIIRGLNLTVKAVAAIMGPNGSGKSTLSYILAGREDEVTEGDILYNGQSIL--------------------------------------------------------------------------------------EMDPAERATSGIFLAFQYPMEIPGVATMEFLKVAMNEQRKARGEEPLKIPEFLKRVKEAAASLNMDMAMLKRPLNV------------------GFSGGEKKRAEILQMKLLEPK--LCVLDETDSGLDIDALKIVSDGVNALRAPDRAFLVITHYQRLLEHIVHVLYRGQVIKSGDKSLALDLEANGYAGV................................... 246
14 -10.200[E] COG4598 ABC-type histidine transport system, ATPase component  ali follow..  14  8.VIDLHYGEHEVLKGVSLQANAVISIIGSSGSGKSTFLRCINFLEKPSEGSIVVNGQTINLVRDKDGQLKVADKNQ----------------------------------------------------------------------------------LRLLRTRLTMVFQHFN--------------------SHMTVLENVMEAPIQVLGLSKQEARERAVKYLAKVGIDERAQGKYPVHLSGGQQQ---VSIARALAMEPEVLLFDEPTSALDPELVGEVLRIMQQLAEEGKTMVVVTHEMGFARHVSTHVI----------------------------FLHQGKIEE-PEQLFGNPQSPLQRFLKGSLK 257
15 -10.200[L] COG1195 Recombinational DNA repair ATPase (RecF pathway)  ali follow..  12  2SLTRLLIKDFRNIENADLALSPFNFLVGANGSGKTSVLEAIYTLGH----------GRAFRSLQPGRVIRHEQEAFVLHGRLQSEERETSIGLTKDKQG---DSKVRIDGTDGHKIAELAHLMPMQLITPEGFTLLNGGPKYRRAFLDWGCFHNEAGFFTAWSNLKRLLKQRNAALRQVSRYEQLRPWDKELIPLAEQISTWRAEYSSAIAQDMADTCQQFLPEFSLTFSFQERDRMLTYTAHG-GQLKLLMCALRLAQGERRCLYLIDDFASELDDARRGLLASRL---KATQSQVFVSISAEHVIDMSDENSKMFTVEKGKIT................................................. 356
16 -10.000[R] COG4152 ABC-type uncharacterized transport system, ATPase component  ali follow..  13  1MLTIDHVTDYKAVDGLDLDIPEQQMLLGANGAGKTTTFRMILGLLSITEGSISWKGRPV--------------------------------------------------------------------------------------------NYHISNKIGYLPEERGLYPKMKVRDQLVYLARLKGMEKREAVKELGTWLERFN----------------------------TDYENKKVEELAKGNQQKIQFISAVL--HKPELLILDEPFSGLDPVNVELLKEAVISLKNSGVSILFSSHVEELCENLCILQKGKPVVQGKLK................................................. 214
17 -10.000[P] COG1117 ABC-type phosphate transport system, ATPase component  ali follow..  13  27.TEDLHYGDNHAIKGVDLTFPEVTALIGPSGCGKSTYLRALNRMNDEIDGCRME-----------------------------------------------------------------------------------------QILYDGININRKEVDLYNVRKEIGMVFQKPNPFTKSIYENVAFGLKRHGMKNKKEIMERVEKSLRRAALWDEVK----------------DDLGKSALSLSGGQQQ---LCIARAVAMQPKVLLLDEPASALDPISTSKIEDLINEL-KNKYTIIIVTHNMQQAARVSDYTSLGEVVEFSGTSELFTNPQEKQTE.................................... 263
18 -9.980[J] KOG0066 eIF2-interacting protein ABC50 (ABC superfamily)  ali follow..  11  352....IKIENFT-FVNANLLIAH---LVGPNGHGKTTLLRHIA--------TRAFAIPPNIDVLLCEQEVVATDKTAINTI-------------------------------------------------------------------------------------------LEADVRRTEMLKKADELEKQFVAGDLTVQEELNDTFAELKAIGAYSAEARARRILAGLGFSKEMQDRPTNKFSGG--WRMRVSLARALYLEPTLLMLDEPTNHLDLNAVIWLDNYLQGWKKT---LLIVSHDQSFLDNVCNEI---HLDQKKLQYY-------------------KGNYSMFKKMYVQKRREMIKEYEKQEKR 605
19 -9.950[CP] COG4555 ABC-type Na+ transport system, ATPase component  ali follow..  11  1MITLTDCSRVKAVRDVSLTIEKGEVILGENGAGKTTMLRMIASLLEPSQGVITVDGFDTV-----------------------------------------------------------------------------------------KQPAEVKQRIGVLFGGETGLYDRMT------AKENLQYFGRLYGLNRHEIKARIEDLSKRFGM--------------------RDYMNRRVGGFSKGMRQKVAIARALI--HDPDIILFDEPTTGLDITSSNIFREFIQQLKREQKTILFSSHVQALCDSVIM-IHSGEVIYRGAL-----YESERSEDLNYIFMSKLVR......................... 243
20 -9.620[S] COG4694 Uncharacterized protein conserved in bacteria  ali follow..  1MIVCIRLKQFGIFNDFN-KFGRYNLVYGWNGTGKSTLSNLFSCFELRSMVPRFVFNQRFVHAEALAAHFSKEFTDFQRRLQNAATWIESQGAPANQLPAATEFYKELSAEADKLQKDYATAAEKIDKQMDGWREALKAKITDPGKTDIQDVVEDDVKNFNEILKSIVALVGKHNNKTSNFKSETSKSKVALELSNETVGAKEFNDILHRFIGRSELCLSFNQKKKGYEIIRNGMGEHDGNLSEGIAFVYFITKLKENGNNIKDTIVVVDDPVSSFDSNHLFHAYSFLRTQCTEAKQLFVLTHNFTYFKLVRDWFTGANRNRI.................................................... 604
21 -9.550[P] COG1121 ABC-type Mn/Zn transport systems, ATPase component  ali follow..  14  12...TVYQGNYLAIRDVSFNLLPDTAIVGPNGAGKSTLVKAILDLIPRRVGQIEIFGRPITKLGNLRHLLGYMPQNFIFDRSFPI----------------------------------------------------------------------SVEELVGLGWVAEARHQKSSFLSKLRIQSREKSAAIATALKRTDTYHLRNQAIGTLS--------------------------------G-GQLK---ILLAYCLVIPRKILVLDEAFAGVDMQGAADFYAMLNELKQQGWTVLQVSHDIDMVSRHCDRVLEIALSPQNLLATY.............................................. 246
22 -9.540[O] COG4133 ABC-type transport system involved in cytochrome c biogenesis, ATPase component  ali follow..  16  1MLEARELLERTLFSGLSFTLNAWVQITGSNGAGKTTLLRLLTGLSRPDAGEVLWQGQPLHQVRD---------------------------------------------------------------------------------------------------SYHQNLLWIGHQPGIKTRLTALENLHFYHRDGDTAQCLEALAQAG------------------------AGFEDIPVNQLSAGQQR---VALARLWLTRATLWILDEPFTAIDVNGVDRLTQRMAQHTEQGGIVILTTHQPLNVAESKIRRI........................................................... 197
23 -9.530[A] KOG0063 RNAse L inhibitor, ABC superfamily  ali follow..  10  68..EAIQIINLPKDLAKDTTHRQVLGLVGTNGIGKSTALKILAGKLKPNLGR------------------------------------------------------------------------------------FNTPPDWEEILTHFRGSELQSYFIRVVEENLKTAIKPQHVDYIKEVVRGNLGKMLEKLDERGLMEEICA----------DMELNQVLER--------------EARQVSGGELQ---FAIAAVFVKKADIYMFDEPSSYLDVRQRLKAAQVIRSLLRHDSYVIVVEHDLSVLDYLFVCCLYGKPGAYGVVTLPFSVREGINVFLAG................................. 315
24 -9.300[R] COG2401 ABC-type ATPase fused to a predicted acetyltransferase domain  ali follow..  14  412VLESFGVRERYVLRDVNLEIKPIVAVVGASGSGKTTFLRLIVGEALKLDDDVYKPSSGMVEVVVDS---------------------------------------------------------------------------------------------------------IAAMIPSELEPQITEKSILEQIFDITGDIHLAVEVLNRAGISDAVLYRA------------------RFNELSTGQKE---FKLAACLAKKPSLMLVDEFAAHLDEMTAVRVARKISELAREKITLIAVTHRKEVINAL---------------------------SPDRILYVGYGGVTESP.................... 620
25 -9.100[E] COG0411 ABC-type branched-chain amino acid transport systems, ATPase component  ali follow..  10  8...SKRFGGLSVLQDVNIEVPQIFGLIGPNGAGKTTVFNLITGLLEPTGGTLTFGGTSLVGKKPHQ------------------------------------------------------------------ITQMGIARTFQNIRIFKEMTLLENVVVGMHRHLDYGAPGLLLSLPG-------------YRAAERRARDRALELLSWVKL--------------------DHKAGDIADNLSYGDQRKLEL--ARALATEPKLLLLDEPVAGMNTGEKVDLMAEIENIRARGYTIFMIEHDMRFVMGLCERIAEAIRNNPQVIEAYLGRDDDDGE..................................... 255
26 -9.050[P] COG1119 ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA  ali follow..  13  14...TFRLSDTKTLQLPQLTLNASWAFVGSNGSGKSALARALAGELPLLKGERQSQFSHITRLS-----------------------------------------------------------------------------------------------FEQLQKLVSDEWQRNNTDMLGPGEDDTGRTTAEIIQDEVKDAPRCMQLAQQFGITPLLDR--------------------RFKYLSTGETR---TLLCQALMSEPDLLILDEPFDGLDVASRQQLAERLASLHQSGITLVLVLNRFDEIPEF-GVLADCTLAET.................................................... 220

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Li W, Jaroszewski L, Godzik A. Tolerating some redundancy significantly speeds up clustering of large protein databases. Bioinformatics. 2002 Jan;18(1):77-82.