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Query: [DZ] COG5019 Septin family protein, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MASMVLADGMPTVKDDSTRSRGSDVDSFTSTDNVTQINVEAAISENKNEEKPIQDNSEQEFNPHVSIIQRQLNGYVGFASLPNQWHRRCVRQGFNFNVLVLGESGSGKSTLVNTLLNRDVYPPTQKSLTGDFGVNPEPTVMINSSAVEIVENGISLQLNVIDTPGFGDFIDNTDCWQPVLTDIEGRYDQYLELEKHNPRSTIQDPRVHACIFFIQPTGHAISAMELRVMLALHEKVNIIPIIAKADTLTDDELNFTKEMILRDIQYHNIRIFFPPTYETDDPESVAENADIMSRIPFAIIASNTFVVNNEGKRVRGRRYPWGVVEVDNEEHSDFPKLREMLIRTHLEELKEQTNKLYEAYRTERLLSSGISQDHSVFREVNPSAKLEEERALHEEKLMKMEAEMKTIFSQKVQEKEDRLKQSENELRTRHREMKAALEKQKADLIDHKNRLMQAKAAAENEKSKRKFFKLast
1 -129.000[DZ] COG5019 Septin family protein  ali  100  1MASMVLADGMPTVKDDSTRSRGSDVDSFTSTDNVTQINVEAAISENKNEEKPIQDNSEQEFNPHVSIIQRQLNGYVGFASLPNQWHRRCVRQGFNFNVLVLGESGSGKSTLVNTLLNRDVYPPTQKSLTGDFGVNPEPTVMINSSAVEIVENGISLQLNVIDTPGFGDFIDNTDCWQPVLTDIEGRYDQYLELEKHNPRSTIQDPRVHACIFFIQPTGHAISAMELRVMLALHEKVNIIPIIAKADTLTDDELNFTKEMILRDIQYHNIRIFFPPTYETDDPESVAENADIMSRIPFAIIASNTFVVNNEGKRVRGRRYPWGVVEVDNEEHSDFPKLREMLIRTHLEELKEQTNKLYEAYRTERLLSSGISQDHSVFREVNPSAKLEEERALHEEKLMKMEAEMKTIFSQKVQEKEDRLKQSENELRTRHREMKAALEKQKADLIDHKNRLMQAKAAAENEKSKRKFFK 469
2 -106.000[DZU] KOG2655 Septin family protein (P-loop GTPase)  ali follow..  37  2.............................................................ADTKGFSSIETPGYVGFANLPNQVHRKSVKKGFEFTLMVVGESGLGKSTLVNSLFLTDLYPERII---PDAIEKQKQTVKLEASTVEIEERGVKLRLTVVDTPGFGDAIDNSNSFGAILEYIDEQYERFLRDESGLNRRNIVDNRIHCCFYFISPFGHGLKPLDVEFMKKLHSKVNIVPVIAKADCLTKKEILRLKCRIMQEIESHGIKIYPLPDCDSDEDEDYKEQVKQLKEAVPFAVCGANTLLEVKGKKVRGRLYPWGVVEVENPDHCDFIKLRTMLI-THMQDLQEVTQEHYENYRSDRLAKGIKGKENGVKAERDSSSQ------VVSNSVLGEKDRILQEKEAELRRMQEMLAQMQARMQAQQ....................................... 361
3 -102.000[D] KOG3859 Septins (P-loop GTPases)  ali follow..  34  2......................................................AATDIARQVGEGCRTVPLAGHVGFDSLPDQLVNKSVSQGFCFNILCVGETGLGKSTLMDTLFNTKFEGEP--------ATHTQPGVQLQSNTYDLQESNVRLKLTIVSTVGFGDQINKEDSYKPIVEFIDAQFEAYLQEELKIRRHTYHDSRIHVCLYFIAPTGHSLKSLDLVTMKKLDSKVNIIPIIAKADAISKSELTKFKIKITSELVSNGVQIYQFPTDDESVAEI----NGTMNAHLPFAVIGSTEELKIGNKMMRARQYPWGTVQVENEAHCDFVKLREMLIRVNMEDLREQTHTHYELYRRCKLEEMGFKDTDPDSKPFSLQETYEAKRNEFLGELQKKEEEMRQMFVQRVKEKEAELKEAEKELHEKFDRLKKLHQDEKKKLEDKKKSLDDEVNAFKQRKTAAELPQ 407
4 -91.300[DTZ] KOG1547 Septin CDC10 and related P-loop GTPases  ali follow..  31  187.AQTLENSEPAPVSQLQSRLEPKPQPPVAEATPRSQEATEAAPSCVGDMADTPRDAGLKQAPASRNEKAPVDFGYVGIDSILEQMRRKAMKQGFEFNIMVVGQSGLGKSTLINTLFKSKISRKSVQ---PTSEERIPKTIEIKSITHDIEEKGVRMKLTVIDTPGFGDHINNENCWQPIMKFINDQYEKYLQEEVNINRKRIPDTRVHCCLYFIPATGHSLRPLDIEFMKRLSKVVNIVPVIAKADTLTLEERVHFKQRITADLLSNGIDVYPQKEFDEDSED--RLVNEKFREMIPFAVVGSDHEYQVNGKRILGRKTKWGTIEVENTTHCEFAYLRDLLIRTHMQNIKDITSSHFEAYRVKRLNEGSSAMANGVEEKEPEAPEM................................................................................... 568
5 -18.700[R] COG0218 Predicted GTPase  ali follow..  22  27................................................................................................EIALAGRSNVGKSSFINTMLNRK---------------NLARTSGKPGKTQLLNFFNIDDKMRFVDVPGYGYARVSKKEREKWGCMIEE----YLTTRENLRA-----------VVSLVDLRHDPSADDVQMYEFLKYYIPVIIVATKADKIPRGKWNKHESAIKKKLN............................................................................................................................................................................................................ 166
6 -17.500[R] KOG2486 Predicted GTPase  ali follow..  19  137................................................................................................EFALVGRSNVGKSSLLNSLVRRK---------------RLALTSKKPGKTQCINHFRINDKWYLVDLPGYG-----ASAPHELKQDWNKFTKDYFLNRSTLV-----------SVFLLVDASIPVKPIDLEYASWLGQNVPMTLIFTKCDKRKKKKNGGKKPEANIKEFQDLIQGF..................................................................................................................................................................................................... 283
7 -15.700[O] KOG0448 Mitofusin 1 GTPase, involved in mitochondrila biogenesis  ali follow..  64.............................................................................LSIIGEVLSRR------HMKVAFFGRTSSGKSSVINAMLWDKVLPSGIGHITNHMDKDLKAGCLVRVFWPKAKCALLRDDLVLVDSPGTDVTTELDS----IDKFCL---------------------DADVFVLVAN-SESTLMNTEKHFFHKVNEWLSKIFILNNRWDASASEPEYMEDVRRQHMER------------HFLVEELKVANALEAQNRIFFVSAKEVLSARKQKAQGMPESGVALAEGFHARLQEFQNFEQIFFEQHTIRAKQILATVKNIMDSVN-LAAEDKRHYSVEEREDQIDRLDFIRNQMNLLTLDVKKKIKEVTEEVANKVSCAMTDEICRLSVLVDEFCSEFHPNPDVLKIYKSELNKHIEDGMGRNLADRCTD 463
8 -15.600[R] COG2229 Predicted GTPase  ali follow..  15  3..............................................................................................ENKIIFTGPVGVGKTTAIAAISDEALVQTDASASDMTLDRKRNTTVAMDYGAISLDED---TKVHLYGTPG------------------QERFNFM--------WEILSQGSMGLVLLLDNARTNPLKDLELHSFRGLLEKAPVVVGITKMDIRSQPGIDVYHKYLAK--HNLNVPVFEIDARKEDD............................................................................................................................................................................................ 160
9 -15.400[R] COG3596 Predicted GTPase  ali follow..  16  16.............................................................................LSGLPLWVSERILQQ--EPVIGIMGKTGAGKSSLCNALFAGEV----------------SPVSDVAACTRDPLRFRLQIGMTIVDLPGVGESGV--------------------RDTEYAALYREQLPRLDLILWLIKAD-DRALATDEHFYRQVIGE-KMLFVISQSDKAEPTS......................................................................................................................................................................................................................... 164
10 -13.000[U] KOG0090 Signal recognition particle receptor, beta subunit (small G protein superfamily)  ali follow..  18  48.......................................................................................RLFRRTKSNTVLLSGLSGSGKTVLFYQLRDGSSHQGAVTSMEPNEGT-------FVLHNENNTKKGKVKPVHLIDVPGHSR--------------LISKLEEYLPR-------------AAAVVFVVDALEFLPNIRAAEYLYDIKNKTPVLLCCNKTDKVTAHTKEFIRKQMEKEIDK........................................................................................................................................................................................................... 200
11 -12.300[E] COG4917 Ethanolamine utilization protein  ali follow..  20  3................................................................................................RIAFVGSVGAGKTTLFNALQGNYTLARKTQAVEFNDK-------------------------GDIDTPG-----------------------EYFNHPRWYHALITTLQDVDMLIYVHGANDP--ESRLPAGLLDIGVSKRQIAVISKTD-MPDADVAATRKLLLE............................................................................................................................................................................................................... 117
12 -11.400[TU] KOG1954 Endocytosis/signaling protein EHD1  ali follow..  13  4.............................FFRTVPRANRNEITFYPDYEEEGQKKKKTRSMFSWLGGDSSKKKNKEVLETVSEGLRKLPLEEFHKFHILLVGQYSTGKTTFIRYLLESDVMHGDEEGSIPGNALVVDAKKQLNRFQCSTLPNQVLESVTIVDTPGI-QRIDRGYDFTGVLEWFAE--------------------RVDRIILLFDAISDEFKRC-IEALAGNEDKIRIV--LNKSDMVDHQQLMRVYGALMWSLGK........................................................................................................................................................................................................... 276
13 -11.200[V] KOG1707 Predicted Ras related/Rac-GTP binding protein  ali follow..  10  6......................................................................................GDSSGSPKPIRIVVVGEKGSGKSSLIMAAARNTFHPN---------------PSLLPYTNLPSEFFPDRIPATVIDTSS--------------------------PEDKGKVVKEVRQADA-IVLTFAFDRPETLDRLSKYWLPLFRQLEVRVPIIYEVDNKEAYNHFSIEQITSALMKQYEVETSIQWSAQRLDQAKDVLYYAQKAVIDPVGPVFDQENNVLKPRCIAALKRIFLLSDHNMDGILSDEELNELLVPCEIKQMKNVMQVTFPQGVNERLRKFGYSNDLRLGDDLVPYSSFKRQADQSVELTNVAIEFLREVYEFFDSNGDNNLEPHEMG............................................ 342
14 -10.900[U] KOG0096 GTPase Ran/TC4/GSP1 (nuclear protein transport pathway), small G protein superfamily  ali follow..  15  13...............................................................................................FKLVLVGDGGTGKTTFVKRHLTGEF------------EKKYIATIGVEVHPLSFYTNFGEIKFDVWDTAG------------------QEKFGG-------LRDGYYINAQCAIIMFDVT-SRITYKNVPHRDLVRVCENIPIVLCGNKVDV----KERKVKAKTITFHRKKNLQYYDISAKSNYNFEK......................................................................................................................................................................................... 161
15 -10.800[R] COG1159 GTPase  ali follow..  16  1....................................................................................MSTDKTYCGF---IAIVGRPNVGKSTLLNKLLGQKI----------SITSRKAQTTRHRIVGIHTEGPY---QAIYVDTPGL-----HMEEKRAINRLMNKAASSSIGD-------------VELVIFVVEGTRWT--PDDEMVLNKLRDKAPVILAVNKVDNVQEKVDLLPHLQFLASQMNFLDIVPISAETGMNVDTIAGIVRKHLPEAIHH--------------------FPEDYITDRSQRFMASEIIREKLMRFLGAELPYSVTVEIERFVTNERGGYDINGLILVEREGQKKMVIGNKGAKIKTIGIEARKDMQEMFEAPVHLEKSGWADDERALRS......................................... 294
16 -10.500[O] COG4133 ABC-type transport system involved in cytochrome c biogenesis, ATPase component  ali follow..  14  2...........................................................................LEARELLCERDERTLFSGLSFTLQITGSNGAGKTTLLRLLTG--SRPDAGEVLWQGQPLHQVRDSYHQNLLWIGHQPGIKTRLTALENLHFYHRDGDTAQCLEALAQAGNQLSAGQQRRVALARLWLTRATL---WILDEP----FTAIDVNGVDRLTQRMAQHTEQGGIVILTTHQPLNVAESKIRRISLTQTRA...................................................................................................................................................................................................... 204
17 -10.400[T] KOG3886 GTP-binding protein  ali follow..  15  36..........................................................................................NTAMKKKVLLMGKSGSGKTSMRSIIF---------ANYIARDTRRLGATILDRIHSLQINSSLSTLVLNLWDCGGQDTFMEN---------YFTSQRDNIFRN-------------VEVLIYVFDVESRELEK--LEAILQNSPDAKIFCLVHKMDLVQEDQRDLIFKEREEDLRR........................................................................................................................................................................................................... 211
18 -10.200[U] KOG3887 Predicted small GTPase involved in nuclear protein import  ali follow..  18  54......................................................................................SDPFSTEVKPRILLMGLRRSGKSSIQKVVFHK---------MSPNETLFLESTNKICREDVSNSSF---VNFQIWDFPG------------------QIDFFDPTFDYEMI-------RGTGALIFVIDSQDDYMEALAVTRAYKVNTDINFEVFIHKVDGLSDDHKIETQRDIHQRANDD.......................................................................................................................................................................................................... 203
19 -10.200[R] KOG1673 Ras GTPases  ali follow..  13  100.............................................................................................VSLKISLLGDCQTGKTTFVVKYVGDEN-------------QSFLEMTGLNLMDKTFYVQGVTISFSIWDVGG------------------EKRSKDHI-------PIACKDAVAILFMFDLT-SRSTLNSVFYSQARKWNKTAIPILIGTKFDRLPPNLQWTIVTQARAYAKVMNASLFFSSATHNINVNK......................................................................................................................................................................................... 257
20 -10.100[R] COG0699 Predicted GTPases (dynamin-related)  ali follow..  12  165.RRVLQAERAKEHRSNSNDKQKSSDNDEDPNDTTVGIGAALAASILSVDSVDGEDTLTADEKRKLAQESKEDRMMLFTKKMIEIRNILQDIQDNN-SIVVIGSQSSGKSSVLEAIVGHEFLPKGSNTDFSKIQHILTDLNMAVPSSQGVDDNPIRLTLSLIDLPGY--QIHSEDQPADLDMKISKLCEKYIREPN--------------IILAVCAADVDLANSALRASRRVDPLLRTIGVVTKMDLVPPSKAISILHNNNYPLHYGYIGVISRIVPTGRFSAGQNLTDLVSTQENSYFSTHQQFADARIGNYL-------GIQSLRK-------CLINVLMSKNLQHTADSIRTELEECNYQYKVQYNDRVLTADSYIAEGLDIFKAAFKEFTQKFGKSEDLLKSSLNEKVMDLLAERYWTDDDISNWSKHTNAL................................. 622
21 -10.100[R] COG1084 Predicted GTPase  ali follow..  14  164................................................................................................TVVIAGFPNVGKSTLLRTLTGAEPEVADYP-----------TTKGIQIGHLERKWK----RIQVIDTPGL----------------LDRPVEDMNNIELQAMVALENIADV--IMFIFDASETLESQYSLYLGIRSVFDIPVVTVFNKMDLAENVKVSKIIKKLEGLYEKETREA...................................................................................................................................................................................................... 332
22 -10.100[M] COG0481 Membrane GTPase LepA  ali follow..  17  6................................................................................................NFSIIAHIDHGKSTLSDRLIQTC--REMEAQVLDSMDLERERGITIKAQSVTLNKDGETYQLNFIDTPGHVD-------------------------SYEVSRS----AACEGALLVVDAGQGVEAQTLANCYTAIEMNLEVVPILNKID-LPAADPERVAEEIEDIVGIDAMEAVRCSAKTGVGIEDVLEE-EGDPNAPLQALIIDSWFDNYLGVVSLVRIKN-GTLRKGDK............................................................................................................................................ 222
23 -9.820[R] KOG0079 GTP-binding protein H-ray, small G protein superfamily  ali follow..  18  11...............................................................................................FKLLIIGDSGVGKSSLLLRFADNTF------------SENYITTIGVDFKIRTMDINGQRVKLQIWDTAG------------------QERFRT-------ITSTYYRGTHGVVVVYDVT-NGESFGNVKLQEIENNCDSVQKVLVGNKCEENERRVVL--ESDARNYAQSMNISFFETSAKEDKNVEP......................................................................................................................................................................................... 161
24 -9.810[T] KOG4252 GTP-binding protein  ali follow..  15  8.............................................................................................VAIKMVVVGNGAVGKSSMIQRYCKGIF------------TKDYKKTIGVDFLERQIQVNDEDVRLMLWDTAG------------------QEEFDA-------ITKAYYRGAQACVLVFSTT-DRGSFEAVSREKVVAEVGDIPTVLVQNKIDLLDDSCIK--NEEAEALAKRLRLRFYRTSVKEDLNVNE......................................................................................................................................................................................... 160
25 -9.790[R] KOG1489 Predicted GTP-binding protein (ODN superfamily)  ali follow..  11  341................................................................................................DLGLIGLPNAGKSTILNKISNAK------------PKIGHWQFTTLSPTIGTVSLGFGQDVFTVADIPGIIQGASLDK--------MGLEFLRHIE-------------RSNGWVFVLDLSNNDLQLLEVGTLEKVKTKNILI-VCNKVDIDAEKSSFAKYLQVEKFSKSQEWDCVPISALREKT............................................................................................................................................................................................ 499
26 -9.790[K] KOG1534 Putative transcription factor FET5  ali follow..  14  4...............................................................................................VAAFVCGVASSGKSTFCGALMS---LDPAAENFEWEPTVDIRDLISIDDVELDYGPNGGLIDYLIFDMPGQIELYTHVPILPALIRHLQVTLNFRP-----------------CAVYLLESQTKFFAGVLSAMSAMVMMEVPHINLLSKMDLLKDNNNITKAE................................................................................................................................................................................................................... 188
27 -9.780[R] KOG0395 Ras-related GTPase  ali follow..  17  3..............................................................................KTLSSGNCTLSVPAKNSYRMVVLGASRVGKSSIVSRFLNGRF------------EDQYTPTIE-DFHRKVYNIRGDMYQLDILDTSG---SLDNRESFDEVKRLQKQ----ILEVKSCLKNKTKEAAELPMVIC-HGELCRQVPTTEAELLVSGDENCAYFEVSAKKNTNVDEMFYVLFSMAKLPHEMS.......................................................................................................................................................................................................... 197
28 -9.770[F] COG1618 Predicted nucleotide kinase  ali follow..  15  2......................................................................................RIEGKEKTMLRIAVTGSPGVGKSTVVAKTAEKTGILSHVKGSGPRLGKYHVNLDDLERIGANAVRNALACDLVVIDEIG---ELISQSFVSAVEEVLESDKPVLAVLHHSSRHPLAQRFRKGFEVLTVDKGNR--DELPEKITNRFLRKLG........................................................................................................................................................................................................................................ 184
29 -9.640[U] KOG0097 GTPase Rab14, small G protein superfamily  ali follow..  13  10.............................................................................................YIFKYIIIGDMGVGKSCLLHQFTEKKF------------MADCPHTIGVEFGTRIIEVSGQKIKLQIWDTAG---DITRRSTYNHLSSWLTD--------------RNLTNPNTVIILIGNKADLEAQRDVTYEEAKQFAEENGLLEASAKTGENVEDAFLEAAKKIYQNIQDGSLD....................................................................................................................................................................................................... 182
30 -9.630[J] KOG0466 Translation initiation factor 2, gamma subunit (eIF-2gamma; GTPase)  ali follow..  12  29..................................................................................TPLSHEVISRQATINIGTIGHVAHGKSTVVKAISGVHTVRFKNELERDDPSCPRPECYRSCGSSMPDENFRLVRHVSFVDCPGHDILMATMLNGAAVMDAA------LIAGNESC---PQPQTSEHLAA---------IEIMKLK---------HILILQNKIDLVKERQAKEQYEQILAFVQGTVAEGAPIIPISAQLKYNIEVVCEYIVKKIPFDVNKGCEVDDLKGGVAGGSILK-GVLKVGQE............................................................................................................................................ 293
31 -9.620[J] KOG0462 Elongation factor-type GTP-binding protein  ali follow..  19  44................................................................................................NFGIVAHVDHGKSTLADRLLECGAVPPGQKQMLDKLQVERERGITVKAQTAALRHRGYL--LNLIDTPGHVD----------------------FSAE--VSRS----AVCDGILLLVAANQGVQAQTIANFWLAFEKNIQIIPVINKID-LPGADIKSVETQLKNLFEFNPEECLHISAKSGEAIIDRVPAPTAIIDAPFRSMIFDSYFDHFRGAIAHIMVKE-GSVKKGDK............................................................................................................................................ 253
32 -9.570[U] KOG0086 GTPase Rab4, small G protein superfamily  ali follow..  13  7.............................................................................................FLFKFLVIGSAGTGKSCLLHQFIENKF------------KQDSNHTIGVEFGSRVVNVGGKTVKLQIWDTAG---DITSRETYNSLAAWLTD--------------RTLASPNIVVILCGNKKDLDPEREVTFLEASRFAQENELLETSALTGENVEEAFLKCARTILNKIDSGELD....................................................................................................................................................................................................... 179
33 -9.540[TU] KOG0084 GTPase Rab1/YPT1, small G protein superfamily, and related GTP-binding proteins  ali follow..  13  9...............................................................................................FKLLLIGDSGVGKSCLLLRFADDSY------------LDSYISTIGVDFKIRTVEQDGKTIKLQIWDTAG---DVTDLESFNNVKQWLNE--------------DRYASENVNKLLVGNKCDLTSQKVVSTETAKAFADELGILETSAKNATNVEEAFMAMTAAIKTRMASQPAG....................................................................................................................................................................................................... 179
34 -9.520[J] KOG0460 Mitochondrial translation elongation factor Tu  ali follow..  13  2...........................................NSAKATSLLFQGFRKNCLRLNRISFASGLINRFTVPARTYADEKVFVRKKPHVNIGTIGHVDHGKTTLTAAILGQASFMDYSQIDKAPEEKARGITISSAHVEYETANR----HYAHVDCPGHADYIKNMITGAATMDGA-----------VSATDGQMPQTREHLLL---------ARQVGVK---------QIVVYINKVDMVEPDMIELVEMEMRELLSEYGFD....................................................................................................................................................................................................... 204
35 -9.520[R] KOG1490 GTP-binding protein CRFG/NOG1 (ODN superfamily)  ali follow..  17  170................................................................................................TVLICGYPNVGKSSFMNKVTRAD----------VDVQPYAFTTKSLFVGHTDYKY----LRYQVIDTPGI---LDRPFEDRNIIEMCSITALAHLRA---------------AVLFFLDISGSCGYTIAFHSIKSLFMNKPLVIVCNKTDLMPMENISEEDRKLIEEMKSEAMKT...................................................................................................................................................................................................... 317
36 -9.510[U] KOG0095 GTPase Rab30, small G protein superfamily  ali follow..  16  10...............................................................................................FKIVLIGNAGVGKTCLVRRFTQGLF------------PPGQGATIGVGFMIKTVEINGEKVKLQIWDTAG------------------QERFRS-------ITQSYYRSANALILTYDITESFRCLPEWLREIEQYASNKVITVLVGNKIDLAERREVS--QQRAEEFSEAQDMYYLETSAKESDNVEK......................................................................................................................................................................................... 161
37 -9.500[U] KOG0093 GTPase Rab3, small G protein superfamily  ali follow..  13  23...............................................................................................FKILIIGNSSVGKTSFLFRYADDSF------------TPAFVSTVGIDFKVKTIYRNDKRIKLQIWDTAG---DITNEESFNAVQDWSTQ--------------KTYSWDNAQVLLVGNKCDMEDERVVSSERGRQLADHLGFFEASAKDNINVKQTFERLVDVICEKMSESLDT....................................................................................................................................................................................................... 193
38 -9.480[U] KOG0087 GTPase Rab11/YPT3, small G protein superfamily  ali follow..  13  9.............................................................................................YLFKTVLIGDSGVGKSNLLMRFTRNEF------------NIESKSTIGVEFATRNIVLDNKKIKAQIWDTAG---DITKQSSFDNVGRWLKE--------------REHADSNIVIMLVGNKTDLLHLRAVSTEEAQAFAAENNLIETSAMDASNVEEAFQTVLTEIFRIVSNRSLE....................................................................................................................................................................................................... 181
39 -9.440[R] COG1160 Predicted GTPases  ali follow..  5................................................................................................VVALVGRPNVGKSTLFNRLTRTR-------------DALVADFPGLTRDRKYGHAHIAGYDFIVIDTGGIDGTEEG------VEEKMAEQSLLAIDEAD--------------IVLFLVDARAGLTAADIGIANYLRQRQNTVVVANKTDGIDADSIAASQGRGVTQLMEQVLAPFAEKMENADENDRTSEEEQDEWEQEFDFDSEEDTALIDDALDEELEEEQ--KIAIVGRPNVGKSTLTNRILGEDVFDMPGTTRD-RDGQQYTLIDTAGVRKRGKVHLAVEKFSVIKTLQAIQDANISDQDLSLLGFILNAGRSLVIVVNKWDGLDQDVKDRVKSELDRRLDFI......................... 358
40 -9.430[R] KOG2485 Conserved ATP/GTP binding protein  ali follow..  12  130...................................................................................LKLKEVIAREPTLLVMVVGVPNVGKSALINSIHQIAAARFPVQERLKRATVGPLPGVTQDIAGFKIAHRP---SIYVLDSPGV------------LVPSIPDIETGLKLALSGSVKDSVVGEEAQYFLAILNIRGTPLHWKYLVEGINEGPHADCIDKPSYNLKDLRHQPDSSALHYVGDMISEVQRSLYITLSEFDGDTEDENDLECLIEQQFEVLQKALKIPHKASEARL-RTGRLGPFILDDETETDHPNSKRVVV............................................................................................................................... 390
41 -9.430[U] KOG0098 GTPase Rab2, small G protein superfamily  ali follow..  14  1.........................................................................................MSYAYLFKYIIIGDTGVGKSCLLLQFTDKRF------------QPVHDLTIGVEFGARMVTIDGKQIKLQIWDTAG---DITRRDTFNHLTSWLED--------------RQHSNSNMVIMLIGNKSDLEARREVKREEGEAFAREHGLMETSAKTAANVEEAFIDTAKEIYRKIQEGVFD....................................................................................................................................................................................................... 177
42 -9.430[TU] KOG0078 GTP-binding protein SEC4, small G protein superfamily, and related Ras family GTP-binding proteins  ali follow..  14  10...............................................................................................IKLLLIGDSGVGKSCLLLRFSEDSF------------TPSFITTIGIDFKIRTIELDGKRIKLQIWDTAG---DVTDKKSFDNVRTWFSN--------------EQHASENVYKILIGNKCDCEDQRQVSFEQGQALADELGVLEASAKTNVNVDEAFFTLAREIKKQKIDAENE....................................................................................................................................................................................................... 180
43 -9.380[R] KOG2203 GTP-binding protein  ali follow..  14  16........................................................................NGEFNVKGLDNFVKKTKLSDGLSYAVVIMGPQSSGKSTLLNHLFKTSF------REMDAFAGRSQTTKGIWMARCVGIEP-----TIAMDLEGTDGRERGED-------------DTTFEKQSALFAIAVAD------IVLINMWCHDIGREQAANKPLLKTVFQVM-LFVIRD-KTKTPIELLERALREDIQK-NVMIVALSSYEEKEKQFEQEVAELRQRFF----ISPGGLAGDRRGVVPASGFSWKVIK--ENRDLDLPAHKVMVATVRCEEIANEKLRDLATNESWLELHEAAEGGLVPGFGKKLSSILEKYFSEYDAEAIYFDEGVRKEKRLQLKLNSNALESFKIRLEQSLNQGEGFAKAVRDSQQSCLMVFDKGCEDAAVKQATWDASK 432
44 -9.360[UR] KOG0446 Vacuolar sorting protein VPS1, dynamin, and related proteins  ali follow..  13  25.............................................................................VNKLQDIFAQLGSQSTIALQVAVVGSQSSGKSSVLEALVGRDFLPRGNREIEAETNRVSGENKGVSDIPIGLKIFSPNVDISLVDLPGI--KVPVGDQPSDIEARIRTMILTYIKEPSCL------------ILAVSPANTDLANSDALQIAGNADPDHRTIGVITKLDIMDRGT--DARNHLLGKTIPLRLGYVGVVNRSQEDILMNRSIKDALVAEEKF------------------RSRPVGVPQLAK-------KLNQVLIKALLPSLKSRINNALFATAKE-YESYGDITESRGGQGALLLSFITKYCEAYSSTLEGKSKEFQSVFVKSLEEVDPCEDLTADDIRTAIQN..................................... 414
45 -9.340[U] KOG0092 GTPase Rab5/YPT51 and related small G protein superfamily GTPases  ali follow..  14  19.............................................................................................CQFKLVLLGESAVGKSSLVLRFVKGQF------------HEFQESTIGAAFLTQTVCLDDTTVKFEIWDTAG------------------QERYHS-------LAPMYYRGAQAAIVVYDITESFARAKNWVKELQRQASPNIVIALSGNKADLANKRAVD--FQEAQSYADDNSLLFMETSAKTSMNVNE......................................................................................................................................................................................... 172
46 -9.340[R] KOG0394 Ras-related GTPase  ali follow..  15  2........................................................................................PSRRRTLLKVIILGDSGVGKTSLMNQYVNKKF------------SNQYKATIGADFLTKEVQFEDRLFTLQIWDTAG---DVNSMKSFENLNNWREEFLIQASPSDPENFPFVLIGNKVDV-------DDGNSRVVSEKKAKAWCASKGNIPYFAKVGTNVEEAFQCIAKDALKSGEEEELY....................................................................................................................................................................................................... 186
47 -9.270[R] KOG0393 Ras-related small GTPase, Rho type  ali follow..  14  3..............................................................................................AIKCVVVGDGAVGKTCLLLSYTTNAFPGE---------------LTVFDTYSTNVMVDGRPINLSLWDTAG------------------QDDYD-------QFRHLSFPQTDVFLVCFALN-NPASFENVRAKWYPEVSHHCPNTPII-REDRDTIERLRESRLQPVSHTQGYVM........................................................................................................................................................................................................ 145
48 -9.250[R] KOG0088 GTPase Rab21, small G protein superfamily  ali follow..  17  1...................................................................................MLETNVDQKSFKFKIVLLGEGCVGKSSLVLRFVENKF------------SCKHLSTIQASFQNKTVNVEDCQADLHIWDTAG------------------QEKYHA-------LGPIYYRGSNGVLLVFDITKSFEKVKNWVLEIKTCLGNTAEILIVGNKIDQVTRQDAEAYAES.................................................................................................................................................................................................................. 146
49 -9.230[U] KOG0094 GTPase Rab6/YPT6/Ryh1, small G protein superfamily  ali follow..  14  10...............................................................................................YKLVFLGDQSVGKTSIITRFMYDKF------------DTTYQATIGIDFLSKTMYLEDRTVRLQLWDTAG------------------QERFRS-------LIPSYIRDSSVAVVVYDVALSFLNTSKWIEEVRNERAGDVIIVLVGNKTDLVEKRQVS--IEEGDSKGREYGVMFIETSAKAGFNIKP......................................................................................................................................................................................... 161
50 -9.190[S] COG4913 Uncharacterized protein conserved in bacteria  ali follow..  10  46................................................................................................SGLLTGDIGSGKSTLIDAI---------------------------------------TTLLVPAQRVAYNKAAGADARERSLRSYVLGYYKSERNDATGTAKPVATSNYSVILGVFHNVGYDKVITLAQVFLKDSQSQPARLFVVAERALGIAADFNNLGKTLRKKLRGAGCEVFD-------------SFPPYGAWFRRRFGIQHEQALELFHQTVSMK-------SVGNLT--DF--VCSHMLEP--CDVGSRIEALICHFDDLDRAHQAVLTAKQQVKLLVPLVDDVQKHQTQLASIQALEAGRDTLRPYFAQLKGELLKHRLDALAAEAAQLTVEIQHLEEQRKAADSEVTQLRQALRDNGGDRL... 357
51 -9.160[U] KOG0076 GTP-binding ADP-ribosylation factor-like protein yARL3  ali follow..  20  17..............................................................................................QYSILILGLDNAGKTTFLETL-------KKEYSLAFKALEKIQPTVGQNVATIPVDSKQI---LKFWDVGG---------------ESLRSMWSEYYSL-------------CHGIIFIVDSSDRERLDECSTTLQSV-EGVPILMLANKQDRMEVQDIKEVFNKIAEHISARDSRVL..................................................................................................................................................................................................... 165
52 -9.160[R] KOG0080 GTPase Rab18, small G protein superfamily  ali follow..  16  7.............................................................................................TTLKILIIGESGVGKSSLLLRFTDDTF------------DPELAATIGVDFKVKTISVDGNKAKLAIWDTAG------------------QERFRT-------LTPSYYRGAQGVILVYDVT-RRDTFVKLDLNELETYCTRNDIVNMLVKIDEVDRNEGLKFARK.................................................................................................................................................................................................................. 142
53 -9.080[R] KOG1533 Predicted GTPase  ali follow..  15  21..................................................................................EKGENLGSTHWTMYGVLVIGAPGAGKSTFCAGLTD---LDPANDTMAYAPDVNITEMITVNDVRLGLGPNGALKKYLIIDCPGQLELYKSEGELWKVIRFLEKSGVRL------------------CALHLADSLSKFISVALSTLATMVTMEMPQVNCLSKADLFSEDGTYDLEF................................................................................................................................................................................................................... 217
54 -9.050[J] KOG0468 U5 snRNP-specific protein  ali follow..  20  133................................................................................................NVALVGHLHHGKTTFVDCLIRQT--EERQLRYTDTLFTEQERGCSIKATPVTLDVKQKSYLLNIFDTPGHVN---------------------FSDEATAAMR--MSDG----VVLFIDAAEGVMLNTERLLKHAVQERQAITVCINKIDRLILEPPQDAYFKLKHIVEEVNGLL...................................................................................................................................................................................................... 291

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Bossy-Wetzel E, Barsoum MJ, Godzik A., Schwarzenbacher R, Lipton SA. Mitochondrial fission in apoptosis, neurodegeneration and aging. Curr Opin Cell Biol. 2003 Dec;15(6):706-16. Review.