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Query: [U] KOG0076 GTP-binding ADP-ribosylation factor-like protein yARL3, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MFHLVKGLYNNWNKKEQYSILILGLDNAGKTTFLETLKKEYSLAFKALEKIQPTVGQNVATIPVDSKQILKFWDVGGQESLRSMWSEYYSLCHGIIFIVDSSDRERLDECSTTLQSVVMDEEIEGVPILMLANKQDRQDRMEVQDIKEVFNKIAEHISARDSRVLPISALTGEGVKDAIEWMIVRLERNKKSRPPIYKLast
1 -96.600[U] KOG0076 GTP-binding ADP-ribosylation factor-like protein yARL3  ali  100  1MFHLVKGLYNNWNKKEQYSILILGLDNAGKTTFLETLKKEYSLAFKALEKIQPTVGQNVATIPVDSKQILKFWDVGGQESLRSMWSEYYSLCHGIIFIVDSSDRERLDECSTTLQSVVMDEEIEGVPILMLANKQDRQDRMEVQDIKEVFNKIAEHISARDSRVLPISALTGEGVKDAIEWMIVRLERNKKSRPPIYK 198
2 -84.800[U] KOG0070 GTP-binding ADP-ribosylation factor Arf1  ali follow..  31  1MGLSFGKLFSRLFAKKEMRILMVGLDAAGKTTILYKLK------LGEIVTTIPTIGFNVETVEYKNIS-FTVWDVGGQDKIRPLWRHYFQNTQGLIFVVDSNDRDRVVEARDELHRMLNEDELRDAVLLVFANKQDLPNAMNAAEITDKLGL--HSLRQRHWYIQSTCATSGEGLYEGLDWLSNNIASK......... 180
3 -84.800[U] KOG0072 GTP-binding ADP-ribosylation factor-like protein ARL1  ali follow..  34  1MDGGVLSYFRGLLGSREMRILILGLDGAGKTTILYRLQ------VGEVVTTIPTIGFNVEQVTYKNLK-FQVWDLGGQTSIRPYWRCYYSNTDAIIYVVDSADRDRIGISKDELLYMLREEELAGAILVVLANKQDMDGCMTVAEVHHALGL--ENLKNRTFQIFKTSATKGEGLDQAMDWLSNTLQSRK........ 181
4 -84.700[R] KOG0074 GTP-binding ADP-ribosylation factor-like protein ARL3  ali follow..  35  1MGLLSILRKLKSAPDQEVRILLLGLDNAGKTTLLKQLAS------EDISHITPTQGFNIKSVQSQGFK-LNVWDIGGQRKIRPYWKNYFENTDILIYVIDSADRKRFEETGQELAELLEEEKLSCVPVLIFANKQDLLTAAPASEIAEGLNL--HTIRDRVWQIQSCSALTGEGVQDGMNWVCKNVNAKKK....... 182
5 -84.100[U] KOG0071 GTP-binding ADP-ribosylation factor Arf6 (dArf3)  ali follow..  33  5LFKGFSKPFSRLFSNKEMRILMLGLDAAGKTTILYKLK------LNQSVVTIPTVGFNVETVTYKNIK-FNVWDVGGQDKIRPLWRHYFTGTKGLIFVVDSADSNRISEARQELHRIISDREMRDCLLLVLANKQDLPGALSPAQITDVLQL--DKLKDRLWNVQPTCALTGDGLLEGLAWLSQNAKLK......... 184
6 -82.600[UZ] KOG0073 GTP-binding ADP-ribosylation factor-like protein ARL2  ali follow..  35  3...LLTILKKMKQKERELRLLMLGLDNAGKTTILKKFNG------EDIDTISPTLGFNIKTLEHRGFK-LNIWDVGGQKSLRSYWRNYFESTDGLIWVVDSADRQRMQDCQRELQSLLVEERLAGATLLIFANKQDLPGALSSNAIREALEL--DSIRSHHWCIQGCSAVTGENLLPGIDWLLDDISSRIFT...... 182
7 -82.600[R] COG1100 GTPase SAR1 and related small G proteins  ali follow..  31  1MGNIFSSMFDKLWSNKELRILILGLDGAGKTTILYRLQ------IGEVVTTKPTIGFNVETLSYKNLK-LNVWDLGGQTSIRPYWRCYYADTAAVIFVVDSTDKDRMSTASKELHLMLQEEELQDAALLVFANKQDQPGALSASEVSKELNL--VELKDRSWSIVASSAIKGEGITEGLDWLIDVIKEEQ........ 182
8 -80.100[R] KOG0075 GTP-binding ADP-ribosylation factor-like protein  ali follow..  27  1MLALINRIFKSIFWKEEMELTLVGLQFSGKTTFVNVIASG-----QFAEDMIPTVGFNMRKITRGNVT-IKVWDIGGQPRFRSMWERYCRGVNAIVYMVDAADLDKLEASRNELHSLLDKPQLAGIPVLVLGNKRDLPGALDETGLIERMNL--SSIQDREICCYSISCKEKDNIDITLQWLIQHSKSQSR....... 186
9 -78.900[U] KOG0077 Vesicle coat complex COPII, GTPase subunit SAR1  ali follow..  26  4FDWFYGILASLGLWQKEAKILFLGLDNAGKTTLLHMLKD------ERLVQHQPTQHPTSEELSIGKIK-FKAFDLGGHQIARRVWKDYYAKVDAVVYLVDAYDKERFAESKRELDALLSDEALATVPFLILGNKIDIPYAASEDELRYHLGLTLGDSGVRPLEVFMCSIVRKMGYGEGFKWLSQYIN........... 193
10 -51.500[U] KOG0090 Signal recognition particle receptor, beta subunit (small G protein superfamily)  ali follow..  18  39LATIWLLSIRLFRRTKSNTVLLSGLSGSGKTVLFYQLRDG-----SSHQGAVTSMEPNEGTFVLHNEKPVHLIDVPGHSRLISKLEEYLPRAAAVVFVVDALEFLPIRAASEYLYDILTNASVNKTPVLLCCNKTDKVTAHTKEFIRKQMEKEIDKL--RVSRSAISTADIANDFTLGIEGEVFSFSH.......... 230
11 -40.100[U] KOG3887 Predicted small GTPase involved in nuclear protein import  ali follow..  12  46TEEGVLDFSDPFSTEVKPRILLMGLRRSGKSSIQKVVFHKMSPN--ETLFLESTNKICREDVSNSSFVNFQIWDFPGQIDFFDPYEMIFRGTGALIFVIDSQDDYMEALARLHLTVTRAYKVNTDINFEVFIHKVDGLSDDHKIETQRDIHQRANDGLEKIHLSFYLTSIYDHSIFEAFSKVVQKLIPQLPTLENLLN 249
12 -35.600[R] COG2229 Predicted GTPase  ali follow..  18  2...............RENKIIFTGPVGVGKTTAIAAISDASASDMTLDRKRNTTVAMDYGAISLDEDTKVHLYGTPGQERFNFMWEILSQGSMGLVLLLDNARTNPLKDLEFFLHSF--RGLLEKAPVVVGITKMDIRSQPGIDVYHKYLAKHNLNVP-----VFEIDARKEDDVKQLVSAMLFSIDPGLE....... 177
13 -31.200[U] KOG0096 GTPase Ran/TC4/GSP1 (nuclear protein transport pathway), small G protein superfamily  ali follow..  20  13.................FKLVLVGDGGTGKTTFVKRHLTGEFEK-----KYIATIGVEVHPLSFFGEIKFDVWDTAGQEKFGGLRDGYYINAQCAIIMFDVTSRITYKNVPNWHRDL--VRVCENIPIVLCGNKVDVKERKVKAKTITF-------HRKKNLQYYDISAKSNYNFEKPFLWLARKLAGNPQLE..... 177
14 -31.000[R] KOG0080 GTPase Rab18, small G protein superfamily  ali follow..  23  9.................LKILIIGESGVGKSSLLLRFTDDTFDP-----ELAATIGFKVKTISVDGNKALAIWDTAGQERFRTLTPSYYRGAQGVILVYDVTRRDTFVKLDNWLNELETYCTRNDIVNMLVGNKIDKENREVDRNEGLKFA------RKHSMLFIEASAKTCDGVQCAFEELVEKIIQTPGLWESENQ 181
15 -30.700[R] KOG0091 GTPase Rab39, small G protein superfamily  ali follow..  18  10.................FRLILIGDSTVGKSSLLKFFTDGKFAE-----LSDPTVGFFARLIEMKDGTQLQLWDTAGQERFRSITKSYYRNSVGVLLVYDISNHASFEHIPLWMMEAQRHIEPHRPVFALVGCKLDLINAGGHREVTT--EEAQKFAKQHGLHFVETSARSGANVEEAFRMVTQEVYARIRS...... 181
16 -30.400[U] KOG0081 GTPase Rab27, small G protein superfamily  ali follow..  20  10.................IKFLALGDSGVGKTSVLYQYTDGKFNS-----KFITTVGFREKRVVYRASGPLQLWDTAGQERFRSLTTAFFRDAMGFLLLFDLTNEQSFLNVRNWISQLQMHAYCENPDIVLCGNKSDLEDQRVVKE-----EEAIALAEKYGIPYFETSAANGTNISQAIEMLLDLIMKRMER...... 187
17 -29.900[T] KOG3886 GTP-binding protein  ali follow..  14  37.............TAMKKKVLLMGKSGSGKTSMRSIIFANYIARLVDSVGNTKTFDVEHSHVRFLGNLVLNLWDCGGQDTFMENYDNIFRNVEVLIYVFDVESRELEKDMHYYQSCLEAILQNSDAKIFCLVHKMDLVQEDQRDLIFKEREEDLRRLSRPLECSCFRTSIWDETLYKAWSSIVYQLIPNVQQLEMNLR 253
18 -29.600[R] KOG0394 Ras-related GTPase  ali follow..  15  9.................LKVIILGDSGVGKTSLMNQYVNKKFSN-----QYKATIGFLTKEVQFEDRLFLQIWDTAGQERFQSLGVAFYRGADCCVLVYDVNSMKSFENLNEEFLIQASPSDPENFPFVLIGNKVDVDDGNSRVVSEKKAKAWCASKGNIPY--FETSAKVGTNVEEAFQCIAKDALKSGEEEE.... 184
19 -29.300[TU] KOG0084 GTPase Rab1/YPT1, small G protein superfamily, and related GTP-binding proteins  ali follow..  26  9.................FKLLLIGDSGVGKSCLLLRFADDS------LDSYISTIGFKIRTVEQDGKTILQIWDTAGQERFRTITSSYYRGAHGIIVTYDVTDLESFNNVKQWLNEIDRYAS-ENVNKLLVGNKCDLTSQKVVST-----ETAKAFADELGIPFLETSAKNATNVEEAFMAMTAAIKTRMASQP.... 177
20 -29.300[R] KOG0079 GTP-binding protein H-ray, small G protein superfamily  ali follow..  20  11.................FKLLIIGDSGVGKSSLLLRFADNTFSE-----NYITTIGFKIRTMDINGQRVLQIWDTAGQERFRTITSTYYRGTHGVVVVYDVTNGESFGNVKRWLQEI--ENNCDSVQKVLVGNKCEENERRVVLE-----SDARNYAQSMNISFFETSAKEDKNVEPMFTCITSLVLTAKLANP.... 178
21 -29.200[TU] KOG0078 GTP-binding protein SEC4, small G protein superfamily, and related Ras family GTP-binding proteins  ali follow..  25  10.................IKLLLIGDSGVGKSCLLLRFSEDS------TPSFITTIGFKIRTIELDGKRILQIWDTAGQERFRTITTAYYRGAMGILLLYDVTDKKSFDNVRTWFSNVEQHAS-ENVYKILIGNKCDCEDQRQVSF-----EQGQALADELGVKFLEASAKTNVNVDEAFFTLAREIKKQKID...... 176
22 -29.100[R] KOG0395 Ras-related GTPase  ali follow..  14  17..............KNSYRMVVLGASRVGKSSIVSRFLNGR------EDQYTPTIEFHRKVYNIRGDMYLDILDTSGNHPFPAMRRLSILTGDVFILVFSLDNRESFDEVKRLQKQILETKEAAELPMVICGNKNDHGELCRQVPTTEAELLVS---GDENCAYFEVSAKKNTNVDEMFYVLFSMAKLPHEMSPALHR 202
23 -29.100[R] KOG0088 GTPase Rab21, small G protein superfamily  ali follow..  20  13.................FKIVLLGEGCVGKSSLVLRFVENKFSC-----KHLSTIQFQNKTVNVEDCQALHIWDTAGQEKYHALGPIYYRGSNGVLLVFDITDRKSFEKVKNWVLEIKTCLG-NTAEILIVGNKIDLEEERQVTR-----QDAEAYAESEGALYMETSAQDNVGISDAFESLTAKMIEHSRTR..... 180
24 -29.100[U] KOG0092 GTPase Rab5/YPT51 and related small G protein superfamily GTPases  ali follow..  18  21.................FKLVLLGESAVGKSSLVLRFVKGQFHE-----FQESTIGFLTQTVCLDDTTVFEIWDTAGQERYHSLAPMYYRGAQAAIVVYDITNEESFARAKNWVKELQRQAS-PNIVIALSGNKADLANKRAVDF-----QEAQSYADDNSLLFMETSAKTSMNVNEIFMAIAKKLPKNEPQNP.... 189
25 -29.000[U] KOG0095 GTPase Rab30, small G protein superfamily  ali follow..  22  10.................FKIVLIGNAGVGKTCLVRRFTQGL------PPGQGATIGFMIKTVEINGEKVLQIWDTAGQERFRSITQSYYRSANALILTYDITCEESFRCLPEWLREIEQYAS-NKVITVLVGNKIDLAERREVSQ-----QRAEEFSEAQDMYYLETSAKESDNVEKLFLDLACRLISEARQNT.... 178
26 -28.800[U] KOG0094 GTPase Rab6/YPT6/Ryh1, small G protein superfamily  ali follow..  20  10.................YKLVFLGDQSVGKTSIITRFMYDKFDT-----TYQATIGFLSKTMYLEDRTVLQLWDTAGQERFRSLIPSYIRDSSVAVVVYDVANRLSFLNTSKWIEEVRNERA-GDVIIVLVGNKTDLVEKRQVS-----IEEGDSKGREYGVMFIETSAKAGFNIKPLFRKIAAALPGMESY...... 176
27 -28.700[U] KOG0093 GTPase Rab3, small G protein superfamily  ali follow..  24  23.................FKILIIGNSSVGKTSFLFRYADDS------TPAFVSTVGFKVKTIYRNDKRILQIWDTAGQERYRTITTAYYRGAMGFILMYDITNEESFNAVQDWSTQIKTYSW-DNAQVLLVGNKCDMEDERVVSS-----ERGRQLADHLGFEFFEASAKDNINVKQTFERLVDVICEKMSES..... 190
28 -28.500[T] KOG4252 GTP-binding protein  ali follow..  17  10.................IKMVVVGNGAVGKSSMIQRYCKGIFTK-----DYKKTIGFLERQIQVNDEDVLMLWDTAGQEEFDAITKAYYRGAQACVLVFSTTDRGSFEAVSSWREKV--VAEVGDIPTVLVQNKIDLLDDSCIKN-----EEAEALAKRLRLRFYRTSVKEDLNVNEVFKYLAEKYLQKLKQQ..... 176
29 -28.400[U] KOG0086 GTPase Rab4, small G protein superfamily  ali follow..  23  9.................FKFLVIGSAGTGKSCLLHQFIENKFKQ-----DSNHTIGFGSRVVNVGGKTVLQIWDTAGQERFRSVTRSYYRGAAGALLVYDITSRETYNSLAAWLTDARTLAS-PNIVVILCGNKKDLDPEREVTF-----LEASRFAQENELMFLETSALTGENVEEAFLKCARTILNKIDS...... 175
30 -28.200[R] KOG1673 Ras GTPases  ali follow..  17  102.................LKISLLGDCQTGKTTFVVKYVG------DENQSFLEMTGLMDKTFYVQGVTIFSIWDVGGDEKSKDHIPIACKDAVAILFMFDLTSRSTLNSVFGWYSQA--RKWNKTAIPILIGTKFDDFVRLPPNLQWTIVTQARAYAKVMNASLFFSSATHNINVNKIFKFILARLFNLPWKIDRNLT 278
31 -28.100[U] KOG0097 GTPase Rab14, small G protein superfamily  ali follow..  23  12.................FKYIIIGDMGVGKSCLLHQFTEKK------MADCPHTIGFGTRIIEVSGQKILQIWDTAGQERFRAVTRSYYRGAAGALMVYDITRRSTYNHLSSWLTDARNLTN-PNTVIILIGNKADLEAQRDVTY-----EEAKQFAEENGLLFLEASAKTGENVEDAFLEAAKKIYQNIQD...... 178
32 -28.000[U] KOG0087 GTPase Rab11/YPT3, small G protein superfamily  ali follow..  20  11.................FKTVLIGDSGVGKSNLLMRFTRNEFNI-----ESKSTIGFATRNIVLDNKKIAQIWDTAGQERYRAITSAYYRGAVGALIVYDITKQSSFDNVGRWLKELREHAD-SNIVIMLVGNKTDLLHLRAVST-----EEAQAFAAENNLSFIETSAMDASNVEEAFQTVLTEIFRIVSNRS.... 179
33 -27.900[U] KOG0098 GTPase Rab2, small G protein superfamily  ali follow..  23  7.................FKYIIIGDTGVGKSCLLLQFTDKR------QPVHDLTIGFGARMVTIDGKQILQIWDTAGQESFRSITRSYYRGAAGALLVYDITRRDTFNHLTSWLEDARQHSN-SNMVIMLIGNKSDLEARREVKR-----EEGEAFAREHGLVFMETSAKTAANVEEAFIDTAKEIYRKIQE...... 173
34 -26.800[R] KOG0083 GTPase Rab26/Rab37, small G protein superfamily  ali follow..  21  469.................GKVIMLGDSGVGKTSLLIRFRDGR-----VPSYFLSTVGFRNKVVVVDGTRVLQIWDTAGQERFRSVTHAYYRDAHALLLLYDVTNKTTYDNIRAWLGEI-REYAQEDVVIVLIGNKADCSGSERQVKREDGERLG----REHNVPFMETSAKTGLNVELSFTAVARQLKSRGYEHGDDGK 643
35 -21.700[R] COG1084 Predicted GTPase  ali follow..  17  159.............DLDAFTVVIAGFPNVGKSTLLRTLTGAEPEVADYPFT---TKGIQIGHLERKWKR-IQVIDTPGNNIELQAMVALENIADVIMFIFDASETCG-YTLESQYSLYLGIRSVFDIPVVTVFNKMDLAENVKYLE----------EYINMVEDPLKVSAFEGRGVSKIIKKLEGLYEKETREAHDNV. 336
36 -21.100[R] KOG0393 Ras-related small GTPase, Rho type  ali follow..  14  2...............QAIKCVVVGDGAVGKTCLLLSYTTNAFPG-----EYILTVTYSTNVMVDGRPINLSLWDTAGQDDYDQFRHLSFPQTDVFLVCFALNNPASFENVRAKWYPEVSH-HCPNTPIILVGTKADLREDRDTIERLRESRLQPVSHTQKAVKYLECSALTQIGLKQVFDEAIRTGLTPPQTPQTRAK 188
37 -20.700[V] KOG1707 Predicted Ras related/Rac-GTP binding protein  ali follow..  12  1...MWMGVGDSSGSPKPIRIVVVGEKGSGKSSLIMAAARN------TFHPNIPSL-TNLPSEFFPDRIPATVIDTSSRPEDKGKVVKEVRQADAIVLTFAFDRPETLDRLSKYWLPLFRQLE-VRVPIIVAGYEVDNKEAYNHFSIEQITSALMKQYREVETSIQ-WSAQRLDQAKDVLYYAQKAV............ 177
38 -20.400[E] COG4917 Ethanolamine utilization protein  ali follow..  13  3..................RIAFVGSVGAGKTTLFNALQGNY---------------TLARKTQAVEFNDKGDIDTPGHPRWYHALITTLQDVDMLIYVHGANDPESRLPAGLL-------DIGVSKRQIAVISKTDMPDADVAATRKLLLETGFEE------PMFELNSHDPQSVQQLVDYLASLTKQEEAGEKT... 155
39 -20.100[R] COG3596 Predicted GTPase  ali follow..  16  36..............HYEPVIGIMGKTGAGKSSLCNALFAGEVSPVSDVAAC--TRDPLRFRLQIGEHF-MTIVDLPGDTEYAALYREQLPRLDLILWLIKADD--RALATDEHFYRQVIGEA-YRHKMLFVISQSDKAEPTSGGNILSTEQKQNISRKICLLHVCAVSVRLQWGLRVMAERMIKCLPREPSS...... 222
40 -19.900[R] KOG2486 Predicted GTPase  ali follow..  16  137..................EFALVGRSNVGKSSLLNSLVRR-----KRLALTSKKPGKTQCINHFRINDKWYLVDLPGPHELKQDWNKFTSTLVSVFLLVDA--SIPVKPIDLEYASWLGQ---NQVPMTLIFTKCDKRKKKKNGGKKPEANIKEFQDLIQGFPWIMTSSVTNQGRDEILLHMAQLRNYWLKH...... 318
41 -18.800[R] KOG1489 Predicted GTP-binding protein (ODN superfamily)  ali follow..  19  337..............KSIADLGLIGLPNAGKSTILNKISNAKPKIGHQFTTLSPTIGT-------FGQDVFTVADIPGDKGMGLEFLRHIERSNGWVFVLDLSNKNPLNDLQLLIEEVGTLEKVKTKNILIVCNKVDIDAE--KSESFAKYLQVEKFSKSQEWDCVPISALREKT........................ 499
42 -18.300[T] KOG0099 G protein subunit Galphas, small G protein superfamily  ali follow..  19  38..............RATHRLLLLGAGESGKSTIVKQMRILHVNGFNGLRCRVLTSGIFETKFQVDKVN-FHMFDVGGQRDERRKWIQCFNDVTAIIFVVEDNQTNRLQEALNLFKSIWNNRWLRTISVILFLNKQDLLAEKVLAGKSKIEDYFPEFARYTTPEDATPEPGEDPRVTRAKYFIRDEFLRISTASGDGRH 357
43 -18.000[R] KOG1490 GTP-binding protein CRFG/NOG1 (ODN superfamily)  ali follow..  15  171...................VLICGYPNVGKSSFMNKVTRADVDVQPYAFT---TKSLFVGHTDYKYLR-YQVIDTPG-EMCSITALAHLRAAVLFFLDISGSCGYTIAQQAALFHSI--KSLFMNKPLVIVCNKTDLMPMENISEEDRKLAMKTAMGASEEQVLLKMSTLTDEGVMSVKNAACERLLDQRVEAKMKSK 361
44 -17.900[DT] KOG0082 G-protein alpha subunit (small G protein superfamily)  ali follow..  19  31..............ARTVKLLLLGAGESGKSTIVKQMKIIHKNGYSELHSRVKTTGIIETQFSFKDLH-FRMFDVGGQRSERKKWIHCFEGVTCIIFCAEDEEVNRMHESLHLFNSICNHKYFSTTSIVLFLNKKDITFEDAGNYIKNQFLDLNLKKEDKEIYSHMTCATDTQNVKFVFDAVTDIIIKEN........ 347
45 -17.600[T] KOG0085 G protein subunit Galphaq/Galphay, small G protein superfamily  ali follow..  17  37..............RRELKLLLLGTGESGKSTFIKQMRIIHGAGYSELRVRVPTTGIIEYPFDLENII-FRMVDVGGQRSERRKWIHCFENVTSIMFLVESDNENRMEESKALFRTIITYPWFQNSSVILFLNKKDLREPQAAREFILKMFVDLNPDSDKIIYSHFTCATDTENIRFVFAAVKDTILQLN........ 352
46 -16.800[J] KOG0466 Translation initiation factor 2, gamma subunit (eIF-2gamma; GTPase)  ali follow..  15  34.........EVISRQATINIGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIRLVRHVSFVDCPGHDILMATMLNGAAVMDAALLLIAGNESCPQPQTSEHLAAI---EIMKLKHILILQNKIDLVKERQAKEQYEQILAFVQGTVAEGAPIIPISAQLKYNIEVVCEYIVKKIPVPPRDFTSEPR 255
47 -16.400[R] COG0218 Predicted GTPase  ali follow..  18  27..................EIALAGRSNVGKSSFINTMLNR-----KNLARTSGKPGKTQLLNFFNIDDKMRFVDVPGSKKEREKWEEYLTTRENLRAVVSLVDLRHDPSADDV--QMYEFLKYYEIPVIIVATKADKIPRGKWNKHESAIKKKLNFDPSDD--FILFSSVSKAGMDEAWDAILEKL............ 195
48 -16.200[R] COG0536 Predicted GTPase  ali follow..  15  155................ELKSMLVGFPSAGKSSLISVMSAAKPKIGDPFTTLQPNLG-----VVNVGHETFTMADVPGGKGLGLDFLRHIERTSVLVHVVDTATMDPGRDPISDIEALEAE-DLSQRPRLVVLNKADVPEAEELAEF-----LKEDIEKQFGWPVFIISAVARKGLDPLKYKLLEIVQDARKKRPKE.. 350
49 -15.500[R] COG1160 Predicted GTPases  ali follow..  15  5..................VVALVGRPNVGKSTLFNRLTRTRDALVADFPGL--TRDRKYGHAHIAG-YDFIVIDTGGEEKMAEQSLLAIDEADIVLFLVDA--RAGLTAADIGIANYLRQR--QNKITVVVANKTDGIDADSHCAEFYQLGLG---------EIEQIAASQGRGVTQLMEQVLAPFAEKMENADE... 173
50 -15.300[P] COG0370 Fe2+ transport system protein B  ali follow..  22  2...............SQNTYCILGNPNTGKTSLFNALTGSY-------EYVGNWSGVTVEKKV--RSKTGKLIDLPGIYDLNPVVTRFLEKFDCMLNIVDSSQIERNLNLTVQLLEY-------GAPVVMGLNMIDVAAGLNIQNLAKKLRIP----------ILPVVARSGKGTEDILSTLSEKHVAPAI....... 166
51 -15.100[J] COG5257 Translation initiation factor 2, gamma subunit (eIF-2gamma; GTPase)  ali follow..  17  1...........MKNQSEINIGLVGHVDHGKTTLTKALSGVWTDTHSEETKRGISIRLGYADITFRKLRKVSFVDAPGHETLMATMLSGAALMDGAILVIAANEPCPQPQTKEHLMAL---DVIGVKDVIVVQNKIDIVSKERALESYREIKEFVKGTCAEDAPIIPVSAQQGANIDILIETIEERIKTPKRDVDKPAR 209
52 -14.500[S] KOG4273 Uncharacterized conserved protein  ali follow..  13  2..............ESRPGVLVVGSSGVGKRTLLSRLLSVEFEDSSESSSQTEVHGWTINTKYYT--ADVSVCISHICDEYSLPNLPNSHPLVALVMVFDLSELSTLVALQDWVSHT---DINSFDILLCIGNKVDRHHLAHDEYRRRLLKASDPSSDIDDFGISETEGSSLLGSEDALEWCSEN............. 181
53 -14.400[R] KOG0410 Predicted GTP binding protein  ali follow..  21  312...................VSLVGYTNAGKSTLLNQLTGANVLAENRL----ATLDPTTRRVQMQNGKEFLLTDTVGPTTLVAAFRATLEESSLLVHVVDISHPL-AEQQIEAVEKVMSELDVSSIPKLVVWNKVDRVDDPQKVKL----------EAEETGDTICISALTGEGLDDFCNAVHEKLKDSMVW...... 478
54 -14.400[R] COG1159 GTPase  ali follow..  21  11...................IAIVGRPNVGKSTLLNKLLGQ---KISITSRKAQTTRHRIVGIHTEGPYQAIYVDTPGNRLMNKAASSSIGDVELVIFVVEGTRWTPDDE------MVLNKLRDGKAPVILAVNKVDN--VQEKVDLLPHLQFLASQMNFLD--IVPISAETGMNVDTIAGIVRKHLPEAIHHFPE... 182
55 -14.400[OK] COG0378 Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase  ali follow..  18  2..............KRPLIIGVGGPVGAGKTMLIERLTRYLSTKGYSMAAITNDIYTKEDADKHPDLQLLFLESGGDNLS-----TFSPDLVDFSIYIIDVAQGEKIPRKGGQGMIKSD---------LFIINKVDLAPYVGAN--VEVMKADTLKSRGNK-DFFVTNLKTDEGLKSVADWIEKRLQLALLEE..... 206
56 -14.400[J] KOG1145 Mitochondrial translation initiation factor 2 (IF-2; GTPase)  ali follow..  21  183...................VTIMGHVDHGKTTLLDKFRKTQVAA-VETGGITQHIG--AFLVSLPSGEKITFLDTPGHAAFSAMRARGAQVTDIVVLVVAADD------VMKQTVESIQHAKDAQVPIILAVNKCDKAEA-DPEKVKKELLAYDVVCED-DVQAVPVSALTGDNLMALAEATV............... 339
57 -13.900[R] COG2262 GTPases  ali follow..  19  200...................VSLVGYTNAGKSTLFNRITEARVYAADQL---FATLDPTLRRIDVADVGETVLADTVGPHDLVAAFKATLQEATLLLHVIDAADVR-VQENIEAVNTVLEEIDAHEIPTLLVMNKIDM---------LEDFEPRIDRDEENKPIRVWLSAQTGAGIPQLFQALTERLSGEVAQ...... 367
58 -13.500[R] COG1163 Predicted GTPase  ali follow..  16  60...........VARTGVASVGFVGFPSVGKSTLLSKLTGTESEAAEEFTTLVTVPGV----IRYKGAK-IQMLDLPGGRGRGKQVIAVARTCNLLFIILDVNKPHHKQIIEKELEGV--GIRLNKTPPDILIKKKEKGGI.......................................................... 190
59 -13.400[T] KOG1487 GTP-binding protein DRG1 (ODN superfamily)  ali follow..  16  59...........VAKTGDARIGFVGFPSVGKSTLLSNLAGVYSEVAAEFTTLTTVPGV----IRYKGAK-IQLLDLPGGKGRGRQVIAVARTCNLILIVLDVLKPGHKKIIENELEGF--GIRLNSKPPNIGFKKKDKGGI.......................................................... 189
60 -12.900[R] COG0486 Predicted GTPase  ali follow..  16  211LDHVRSEAKQGSILREGMKVVIAGRPNAGKSSLLNALAGREAAIVTDIAGT--TRDVLREHIHIDGMP-LHIIDTAGLREATDE-WSEIEQADRILLMLDSTEA--DNQDLEKVRSEFLTKLPSNIPVTIVRNKADLSGENEGIVEQNGYT------------VITLSAKTQQGIALLREHLKQSMGYQTNM...... 393
61 -12.700[T] KOG1486 GTP-binding protein DRG2 (ODN superfamily)  ali follow..  14  57...........VTKYGHGRVALIGFPSVGKSTLLTMLTGTHSEAASEFTTLTCIPGV----IHYNDTK-IQLLDLPGGKGRGRQVIAVAKSSDLVLMVLDSKSEGHRQILTKELEAV--GLRLNKTPPQIYFKKKKTGGI.......................................................... 187
62 -12.600[J] KOG1191 Mitochondrial GTPase  ali follow..  14  337VESALDTANYDKLLQSGLQIAIVGRPNVGKSSLLNAWSKSERAIVTEVAGT--TRDVVEANVTVRGVP-ITLLDTAGIRETNDI-ETAAKVADVIIMAVSAVEGWTEEDTEVSFYDLFGGLLYLKQPMILVMNKIDCAPPGSCDQLEDQRKKEEVFHK-----SVFTSAVTGQGIEELEDAILEILGLDR........ 537
63 -12.300[M] COG0481 Membrane GTPase LepA  ali follow..  16  9....................IIAHIDH-GKSTLSDRLDREMEAQVLDSMDLERERGITIKAQSVTETYQLNFIDTPGHVDFSYEVSRSLAACEGALLVVDAGQ------VEAQTLANCYTAIEMNLEVVPILNKIDLPAADPERVAEEIEDI----VGIDAMEAVRCSAKTGVGIEDVLEEIVHKIPAPEGDPNAPLQ 192
64 -12.100[J] COG4108 Peptide chain release factor RF-3  ali follow..  15  13..............SKRRTFAIISHPDAGKTTITEKVRGSNQHAKSDWMEMEKERGISVTTSVMQGDCLVNLLDTPGHEDFSEDTYRTLTAVDSCLMVIDAAK------VEDRTRKLMEVTRLRDTPIVTFMNKLDREIR-LMDEVENELKIACSPIT........................................ 172
65 -12.000[J] COG3276 Selenocysteine-specific translation elongation factor  ali follow..  20  1....................MIIVVDH-GKTALLKALTGTSTAHLPEEKKRGMTIDLGYAYLPLENKV-LGFIDVPGHEKFLSNMLAGLGGVHYAMLIV-AADEGVAVQTKEHLAIL---RQLQFHEIIVVITKADRTNSAQIESLIQTIKQDYSFLRNAN--YFVTSAETGQGISELRHYLANLAELADTQKPFRY. 173
66 -11.800[J] KOG0462 Elongation factor-type GTP-binding protein  ali follow..  18  47....................IVAHVDH-GKSTLADRLLEMCGAVPPGQKQMLDTVKAQTAALRHRGYL-LNLIDTPGHVDFSAEVSRSLAVCDGILLLVAANQ------VQAQTIANFWLAFEKNIQIIPVINKIDLPGA----DIKSVETQLKNLFEFNPEECLHISAKSGLNVDKVLEAIIDRVPAPTAIIDAPFR 223
67 -11.700[P] COG2895 GTPases - Sulfate adenylate transferase subunit 1  ali follow..  21  24.............HKSLLRFLTCGSVDDGKSTLLHDTRQIYEDQLSSLHNDSKRHGTQGEKLDLAEKRKFIIADTPGHEQYTRNMATGASTCELAILLIDARK----GVLDQTRRHSFISTLLGIKHLVVAINKMDLVDYSEETRIREDYLTFAGQLPNLDIRFVPLSALEGDNVSESMPW................. 222
68 -11.500[J] COG5256 Translation elongation factor EF-1alpha (GTPase)  ali follow..  16  1.......MKIMASQKPHLNLITIGHVDHGKSTLVGRLLYEHGEIPAHIIEEYRTIDLAHRKFETDK-YYFTLIDAPGHRDFVKNMITGTSQADAAILVISAREGEGVMEQTREHAFLARTLGVPQ--MVVAINKMDATSP-RYNEVKADAEKLLRSIGFKDISFVPISGYKGDNVSPNMPW................. 206
69 -11.400[J] KOG0468 U5 snRNP-specific protein  ali follow..  19  133..................NVALVGHLHHGKTTFVDCLMEERQLRYTDTLFTEQERGCSIKATPVTKSYLLNIFDTPGHVNFSDEATAAMRMSDGVVLFIDA-----AEGVMLNTERLLKHAVQERQAITVCINKIDRLILLPPQDAYFKLKHIVEEVN........................................ 288
70 -11.400[J] KOG0469 Elongation factor 2  ali follow..  13  7.....DEIRALMDRKRNIRMSVIAHVDHGKSTLTDSLVSKAGIIAGSKAGETRFTCITIKSTAIYNGFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDC-----VSGVCVQTETVLRQAIAERIKPVLFMNKMDRALLLGAEELFQTFQRIVENIN........................................ 198
71 -11.000[J] KOG0460 Mitochondrial translation elongation factor Tu  ali follow..  14  50.............KKPHVNIGTIGHVDHGKTTLTAAITKCLSDKAPEEKARGITISSAHVEYETANRH-YAHVDCPGHADYIKNMITGAATMDGAIIVVSATD---MPQTREHLLLA---RQVGVKQIVVYINKVDMVEPDMIELVEMEMRELLSEYGFDGDNTPIVSGSALCALEG..................... 221
72 -11.000[J] KOG0458 Elongation factor 1 alpha  ali follow..  19  164.............ALPHLSFVVLGHVDAGKSTLMGRLLYDLNIVNQSQLRKLQTVSICTSHFSTHR-ANFTIVDAPGHRDFVPNAIMGISQADMAILCVDCSTESGFDLDGQTKEHMLLASSLGIHNLIIAMNKMDNVDWSQQEEIKSKLLLVDIGFFEDNINWVPISGFSGEGVYK..................... 361
73 -10.900[R] COG1223 Predicted ATPase (AAA+ superfamily)  ali follow..  16  138...................VLFYGPPGTGKTMMAKALSNEA----------------KTPFLSVKSTKLIGEHVGDGARRVHELYERARQLAPCIVFLFDAIALDR-GDVSEIVNALLTENSNEGICTIAATNRVELLDASIRSRFEEEIEFRLPSYEER...................................... 273
74 -10.800[J] COG0532 Translation initiation factor 2 (IF-2; GTPase)  ali follow..  19  448...................VTIMGHVDHGKTTLLDRFRESRVTE-GEAGGITQHIGYQIKA----NGKKITFLDTPGHEAFTSMRARGASVTDITILVVAADD------VMPQTIEAINHSKAAGVPIIVAINKIDKPGA-NPQRVTQELTEHGVFPVA-GSEFVEISAKFNQNLDELLDTVLLVAEVQELKADPTVR 620
75 -10.800[F] COG4088 Predicted nucleotide kinase  ali follow..  12  4...................IIVSGYPSSGKTTRSNELKKALEDRIHQNIDNTKDYRVIIINDESLNIEKETYRESKNEKAARGLLYSAVQREKSTFVICDALNYIK--GFRYQLYCESKSMYTTHCVIHVAVPQD............................................................... 119

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Li W, Jaroszewski L, Godzik A. Tolerating some redundancy significantly speeds up clustering of large protein databases. Bioinformatics. 2002 Jan;18(1):77-82.