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Query: [U] KOG0086 GTPase Rab4, small G protein superfamily, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MAETYDFLFKFLVIGSAGTGKSCLLHQFIENKFKQDSNHTIGVEFGSRVVNVGGKTVKLQIWDTAGQERFRSVTRSYYRGAAGALLVYDITSRETYNSLAAWLTDARTLASPNIVVILCGNKKDLDPEREVTFLEASRFAQENELMFLETSALTGENVEEAFLKCARTILNKIDSGELDPERMGSGIQYGDASLRQLRQPRSAQAVAPQPCGCLast
1 -98.000[U] KOG0086 GTPase Rab4, small G protein superfamily  ali  100  1MAETYDFLFKFLVIGSAGTGKSCLLHQFIENKFKQDSNHTIGVEFGSRVVNVGGKTVKLQIWDTAGQERFRSVTRSYYRGAAGALLVYDITSRETYNSLAAWLTDARTLASPNIVVILCGNKKDLDPEREVTFLEASRFAQENELMFLETSALTGENVEEAFLKCARTILNKIDSGELDPERMGSGIQYGDASLRQLRQPRSAQAVAPQPCGC 213
2 -92.900[U] KOG0097 GTPase Rab14, small G protein superfamily  ali follow..  56  5.PYNYSYIFKYIIIGDMGVGKSCLLHQFTEKKFMADCPHTIGVEFGTRIIEVSGQKIKLQIWDTAGQERFRAVTRSYYRGAAGALMVYDITRRSTYNHLSSWLTDARNLTNPNTVIILIGNKADLEAQRDVTYEEAKQFAEENGLLFLEASAKTGENVEDAFLEAAKKIYQNIQDGSLDLNAAESGVQHKPSAPQGGRLTSEPQPQREGCG-C 215
3 -91.500[TU] KOG0084 GTPase Rab1/YPT1, small G protein superfamily, and related GTP-binding proteins  ali follow..  42  1MNPEYDYLFKLLLIGDSGVGKSCLLLRFADDSYLDSYISTIGVDFKIRTVEQDGKTIKLQIWDTAGQERFRTITSSYYRGAHGIIVTYDVTDLESFNNVKQWLNEIDRYASENVNKLLVGNKCDLTSQKVVSTETAKAFADELGIPFLETSAKNATNVEEAFMAMTAAIKTRMASQPAGGSKPPT-----------VQIRGQPVNQQSGCCS. 201
4 -91.400[U] KOG0098 GTPase Rab2, small G protein superfamily  ali follow..  50  2...SYAYLFKYIIIGDTGVGKSCLLLQFTDKRFQPVHDLTIGVEFGARMVTIDGKQIKLQIWDTAGQESFRSITRSYYRGAAGALLVYDITRRDTFNHLTSWLEDARQHSNSNMVIMLIGNKSDLEARREVKREEGEAFAREHGLVFMETSAKTAANVEEAFIDTAKEIYRKIQEGVFDINNEANGIKLGPQHSPSSPNATGGLGGGSGCC.. 214
5 -91.200[U] KOG0087 GTPase Rab11/YPT3, small G protein superfamily  ali follow..  42  4.EDEYDYLFKTVLIGDSGVGKSNLLMRFTRNEFNIESKSTIGVEFATRNIVLDNKKIKAQIWDTAGQERYRAITSAYYRGAVGALIVYDITKQSSFDNVGRWLKELREHADSNIVIMLVGNKTDLLHLRAVSTEEAQAFAAENNLSFIETSAMDASNVEEAFQTVLTEIFRIVSNRSLEAGDDGVHPTAGQTLNIAPTMNDLNKKKSSSQC-C 214
6 -90.800[U] KOG0095 GTPase Rab30, small G protein superfamily  ali follow..  40  3.MEDYDFLFKIVLIGNAGVGKTCLVRRFTQGLFPPGQGATIGVGFMIKTVEINGEKVKLQIWDTAGQERFRSITQSYYRSANALILTYDITCEESFRCLPEWLREIEQYASNKVITVLVGNKIDLAERREVSQQRAEEFSEAQDMYYLETSAKESDNVEKLFLDLACRLISEARQNTLVNNVSSPLPG------------EGKSISYLTCCN. 201
7 -90.600[TU] KOG0078 GTP-binding protein SEC4, small G protein superfamily, and related Ras family GTP-binding proteins  ali follow..  41  3.TKSYDYLIKLLLIGDSGVGKSCLLLRFSEDSFTPSFITTIGIDFKIRTIELDGKRIKLQIWDTAGQERFRTITTAYYRGAMGILLLYDVTDKKSFDNVRTWFSNVEQHASENVYKILIGNKCDCEDQRQVSFEQGQALADELGVKFLEASAKTNVNVDEAFFTLAREIKKQKIDAENEFSNQANNVDLG------------NDRTVKRCC.. 200
8 -89.900[U] KOG0093 GTPase Rab3, small G protein superfamily  ali follow..  34  15SDQNFDYMFKILIIGNSSVGKTSFLFRYADDSFTPAFVSTVGIDFKVKTIYRNDKRIKLQIWDTAGQERYRTITTAYYRGAMGFILMYDITNEESFNAVQDWSTQIKTYSWDNAQVLLVGNKCDMEDERVVSSERGRQLADHLGFEFFEASAKDNINVKQTFERLVDVICEKMSESLDTADPAVTGAKQG-------PQLSDQQVPPHQDCAC 220
9 -89.900[U] KOG0094 GTPase Rab6/YPT6/Ryh1, small G protein superfamily  ali follow..  30  3.SVSPLAKYKLVFLGDQSVGKTSIITRFMYDKFDTTYQATIGIDFLSKTMYLEDRTVRLQLWDTAGQERFRSLIPSYIRDSSVAVVVYDVANRLSFLNTSKWIEEVRNERAGDVIIVLVGNKTDLVEKRQVSIEEGDSKGREYGVMFIETSAKAGFNIKPLFRKIAAALPGMESYSNTKNEDMVD-------VNLKPTSNSSQGDQQGGACSC 207
10 -89.300[R] KOG0088 GTPase Rab21, small G protein superfamily  ali follow..  31  5NVDQKSFKFKIVLLGEGCVGKSSLVLRFVENKFSCKHLSTIQASFQNKTVNVEDCQADLHIWDTAGQEKYHALGPIYYRGSNGVLLVFDITDRKSFEKVKNWVLEIKTCLGNTAEILIVGNKIDLEEERQVTRQDAEAYAESEGALYMETSAQDNVGISDAFESLTAKMIEHSRTRSTEPPSTNRSIRLID---------NDEAERSKKCC.. 206
11 -89.300[U] KOG0092 GTPase Rab5/YPT51 and related small G protein superfamily GTPases  ali follow..  37  13NTGNKICQFKLVLLGESAVGKSSLVLRFVKGQFHEFQESTIGAAFLTQTVCLDDTTVKFEIWDTAGQERYHSLAPMYYRGAQAAIVVYDITNEESFARAKNWVKELQRQASPNIVIALSGNKADLANKRAVDFQEAQSYADDNSLLFMETSAKTSMNVNEIFMAIAKKLPKNEPQNPGANSARGRGVDLTE----------PTQPTRNQCCS. 214
12 -89.200[R] KOG0079 GTP-binding protein H-ray, small G protein superfamily  ali follow..  36  4.TRDYDHLFKLLIIGDSGVGKSSLLLRFADNTFSENYITTIGVDFKIRTMDINGQRVKLQIWDTAGQERFRTITSTYYRGTHGVVVVYDVTNGESFGNVKRWLQEIENNC-DSVQKVLVGNKCEENERRVVLESDARNYAQSMNISFFETSAKEDKNVEPMFTCITSLVLTAKLANPQSASKDQSRTG------GVSLKDNSGSTNQKKKCKC 208
13 -89.100[U] KOG0081 GTPase Rab27, small G protein superfamily  ali follow..  31  3.DGDYDYLIKFLALGDSGVGKTSVLYQYTDGKFNSKFITTVGIDFREKRVVYRGQRIHLQLWDTAGQERFRSLTTAFFRDAMGFLLLFDLTNEQSFLNVRNWISQLQMHAYENPDIVLCGNKSDLEDQRVVKEEEAIALAEKYGIPYFETSAANGTNISQAIEMLLDLIMKRMERCVDKSWIPEGVVRSNGH----ASTDQLSEEKEKGACGC 221
14 -88.400[R] KOG0091 GTPase Rab39, small G protein superfamily  ali follow..  39  2VEPIFEYQFRLILIGDSTVGKSSLLKFFTDGKFAELSDPTVGVDFFARLIEMDGTQIKLQLWDTAGQERFRSITKSYYRNSVGVLLVYDISNHASFEHIPLWMMEAQRHIEPHPVFALVGCKLDLINHREVTTEEAQKFAKQHGLHFVETSARSGANVEEAFRMVTQEVYARIRSGEYKAEDGWDGIKSGFSRPNSLDFNLVVAEPEKSSC-C 218
15 -86.700[R] KOG0080 GTPase Rab18, small G protein superfamily  ali follow..  38  1MDEDVLTTLKILIIGESGVGKSSLLLRFTDDTFDPELAATIGVDFKVKTISVDGNKAKLAIWDTAGQERFRTLTPSYYRGAQGVILVYDVTRRDTFVKLDNWLNELETYCTRNIVNMLVGNKIDKEN-REVDRNEGLKFARKHSMLFIEASAKTCDGVQCAFEELVEKIIQTPGLWESENQNKGVKLSHREE--------GQGGGACGGYCSV 205
16 -82.900[T] KOG4252 GTP-binding protein  ali follow..  27  2LEEDMEVAIKMVVVGNGAVGKSSMIQRYCKGIFTKDYKKTIGVDFLERQIQVNDEDVRLMLWDTAGQEEFDAITKAYYRGAQACVLVFSTTDRGSFEAVSSWREKVVAEVG-DIPTVLVQNKIDLLDDSCIKNEEAEALAKRLRLRFYRTSVKEDLNVNEVFKYLAEKYLQKLKQQIAEDPELTHSSSNKIGVF--NTSGGSHSGQNSGTLNG 211
17 -82.800[R] KOG0394 Ras-related GTPase  ali follow..  33  1MPSRRRTLLKVIILGDSGVGKTSLMNQYVNKKFSNQYKATIGADFLTKEVQFEDRLFTLQIWDTAGQERFQSLGVAFYRGADCCVLVYDVNSMKSFENLNNWREEFLIQASENFPFVLIGNKVDVDDSRVVSEKKAKAWCASKGIPYFETSAKVGTNVEEAFQCIAKDALKSGEEEELYLPDT--------------IDVGTSNQQRSTGCEC 206
18 -76.700[U] KOG0096 GTPase Ran/TC4/GSP1 (nuclear protein transport pathway), small G protein superfamily  ali follow..  27  6.ANGEVPTFKLVLVGDGGTGKTTFVKRHLTGEFEKKYIATIGVEVHPLSFYTNFGEIKFDVWDTAGQEKFGGLRDGYYINAQCAIIMFDVTSRITYKNVPNWHRDLVRVC-ENIPIVLCGNKVDVKERKVK--AKTITFHRKKNLQYYDISAKSNYNFEKPFLWLARKLAGNPQLEFVASPALAP-----PEVQVDEQLMQQYQQEMEQATA. 208
19 -71.800[R] KOG1673 Ras GTPases  ali follow..  22  95.SDSDLVSLKISLLGDCQTGKTTFVVKYVGDEN-QSFLEMTGLNLMDKTFYVQGVTISFSIWDVGGDERSKDHIPIACKDAVAILFMFDLTSRSTLNSVFGWYSQARKWN-KTAIPILIGTKFDDPNLQWTIVTQARAYAKVMNASLFFSSATHNINVNKIFKFILARLFNLPWKIDRNLTLGEPIIDYDS...................... 288
20 -69.500[R] KOG0083 GTPase Rab26/Rab37, small G protein superfamily  ali follow..  38  462.EDEFDIMGKVIMLGDSGVGKTSLLIRFRDGRYVPSYLSTVGIDFRNKVVVVDGTRVKLQIWDTAGQERFRSVTHAYYRDAHALLLLYDVTNKTTYDNIRAWLGEIREYAQEDVVIVLIGNKADCSSERQVKREDGERLGREHNVPFMETSAKTGLNVELSFTAVARQLKSRGYEHGDDGKFNVHDFV------------RDNTKARSVCAQC 663
21 -66.400[R] KOG0395 Ras-related GTPase  ali follow..  20  12LSVPAKNSYRMVVLGASRVGKSSIVSRFLNGRFEDQYTPTIE-DFHRKVYNIRGDMYQLDILDTSGNHPFPAMRRLSILTGDVFILVFSLDNRESFDEVKRLQKQILEVKSAELPMVICGNKNDHELCRQVPTTEAELLSGDENCAYFEVSAKKNTNVDEMFYVLFSMAKLPHEMS----PALHRKISVQYGDAFHPRPFCMRRVKEMDAYGM 230
22 -50.300[R] COG2229 Predicted GTPase  ali follow..  18  4........NKIIFTGPVGVGKTTAIAAISDEALVQTDATTVAMDYGAISL---DEDTKVHLYGTPGQERFNFMWEILSQGSMGLVLLLDNARTNPLKDLEFFLHSFRGLL-EKAPVVVGITKMDIRSQPGIDVYHKYLAKHNLNVPVFEIDARKEDDVKQLVSAMLFSIDPGLE....................................... 177
23 -45.300[R] KOG0393 Ras-related small GTPase, Rho type  ali follow..  26  4........IKCVVVGDGAVGKTCLLLSYTTNAFPGEYILTV-FDTYSTNVMVDGRPINLSLWDTAGQDDYDQFRHLSFPQTDVFLVCFALNNPASFENVAKWYPEVSHHC-PNTPIILVGTKADLREDRDVSHTQGYVMAKEIKVKYLECSALTQIGLKQVFDEAIRTGLTPPQTPQTRAKKS.............................. 190
24 -35.400[T] KOG3886 GTP-binding protein  ali follow..  20  33VLPNTAMKKKVLLMGKSGSGKTSMRSIIFANYIARDTGATILDRIHSLQINSSLGNLVLNLWDCGGQDTFMSQRDNIFRNVEVLIYVFDVESRELEKDMHYYQSCLEAILSPDAKIFCLVHKMDLVQEDQKEREEDLRRLSRPLECSCFRTSIWDETLYKAWSSIVYQLIPNVQQ...................................... 247
25 -35.300[S] KOG4273 Uncharacterized conserved protein  ali follow..  18  2.....ESRPGVLVVGSSGVGKRTLLSRLLSVEFEDSSESSSQTEVHGWTINTKYYTADVSVCISHICDEYSLPNLPNSHPLVALVMVFDLSELSTLVALQDWVSHTDINSFD--ILLCIGNKVDRVPHHLAHDEYRRRYSDIDDFGISETEGSSLLGSEDASLDIRGACLE.......................................... 176
26 -31.400[R] KOG0075 GTP-binding ADP-ribosylation factor-like protein  ali follow..  19  21........MELTLVGLQFSGKTTFVNVIASGQFAEDMIPTVGFNMR----KITRGNVTIKVWDIGGQPRFRSMWERYCRGVNAIVYMVDAADLDKLEASRNELHSLLDKPQAGIPVLVLGNKRDLPDETGLIERMNLSSIQDREICCYSISCKEKDNIDITLQWLIQHSKSQSR....................................... 186
27 -29.400[R] KOG0074 GTP-binding ADP-ribosylation factor-like protein ARL3  ali follow..  23  18........VRILLLGLDNAGKTTLLKQLASEDIS-HITPTQG--FNIKSVQSQG--FKLNVWDIGGQRKIRPYWKNYFENTDILIYVIDSADRKRFEETGQELAELLEEEKSCVPVLIFANKQDLLPASEIAEGLNLHTIRDRVWQIQSCSALTGEGVQDGMNWVCKNVNAKKK....................................... 182
28 -29.300[U] KOG0071 GTP-binding ADP-ribosylation factor Arf6 (dArf3)  ali follow..  21  22........MRILMLGLDAAGKTTILYKLKLNQSV-VTIPTVGFNVE----TVTYKNIKFNVWDVGGQDKIRPLWRHYFTGTKGLIFVVDSADSNRISEARQELHRIISDRERDCLLLVLANKQDLPSPAQITDVLQLDKLKDRLWNVQPTCALTGDGLLEGLAWLSQNAKLK......................................... 184
29 -29.100[U] KOG0070 GTP-binding ADP-ribosylation factor Arf1  ali follow..  22  18........MRILMVGLDAAGKTTILYKLKLGEIV-TTIPTIGFNVE----TVEYKNISFTVWDVGGQDKIRPLWRHYFQNTQGLIFVVDSNDRDRVVEARDELHRMLNEDERDAVLLVFANKQDLPNAAEITDKLGLHSLRQRHWYIQSTCATSGEGLYEGLDWLSNNIASK......................................... 180
30 -29.100[U] KOG0072 GTP-binding ADP-ribosylation factor-like protein ARL1  ali follow..  23  18........MRILILGLDGAGKTTILYRLQVGEVV-TTIPTIGFNVE----QVTYKNLKFQVWDLGGQTSIRPYWRCYYSNTDAIIYVVDSADRDRIGISKDELLYMLREEEAGAILVVLANKQDMDTVAEVHHALGLENLKNRTFQIFKTSATKGEGLDQAMDWLSNTLQSR......................................... 180
31 -29.000[V] KOG1707 Predicted Ras related/Rac-GTP binding protein  ali follow..  17  15........IRIVVVGEKGSGKSSLIMAAARNTFHPNIPSLL--PYTNLPSEFFPDRIPATVIDTSSRPEDKGKVVKEVRQADAIVLTFAFDRPETLDRLSKWLPLFRQL-EVRVPIIVAGYEVDNKEAYNHFSIEQITSALMKQYRSIQWSAQRLDQAKDVLYYAQKAVI........................................... 178
32 -28.800[UZ] KOG0073 GTP-binding ADP-ribosylation factor-like protein ARL2  ali follow..  22  17........LRLLMLGLDNAGKTTILKKFNGEDID-TISPTLG--FNIKTLEHRG--FKLNIWDVGGQKSLRSYWRNYFESTDGLIWVVDSADRQRMQDCQRELQSLLVEERAGATLLIFANKQDLPSSNAIREALELDSIRSHHWCIQGCSAVTGENLLPGIDWLLDDISSRIFT...................................... 182
33 -28.800[R] COG1100 GTPase SAR1 and related small G proteins  ali follow..  22  19........LRILILGLDGAGKTTILYRLQIGEVV-TTKPTIGFNVE----TLSYKNLKLNVWDLGGQTSIRPYWRCYYADTAAVIFVVDSTDKDRMSTASKELHLMLQEEEQDAALLVFANKQDQPSASEVSKELNLVELKDRSWSIVASSAIKGEGITEGLDWLIDVIKEE......................................... 181
34 -28.400[U] KOG0076 GTP-binding ADP-ribosylation factor-like protein yARL3  ali follow..  23  18........YSILILGLDNAGKTTFLETLKKEYSLAKIQPTVG--QNVATIPVDSKQI-LKFWDVGGQESLRSMWSEYYSLCHGIIFIVDSSDRERLDECSTTLQSVVMDEEEGVPILMLANKQDRQDRMEVQDNKIAEHISARDSRVLPISALTGEGVKDAIEWMIVRLERNKKS...................................... 192
35 -27.100[U] KOG0077 Vesicle coat complex COPII, GTPase subunit SAR1  ali follow..  19  21........AKILFLGLDNAGKTTLLHMLKDERLV-QHQPTQH--PTSEELSIGK--IKFKAFDLGGHQIARRVWKDYYAKVDAVVYLVDAYDKERFAESKRELDALLSDEAATVPFLILGNKIDLTNFTTGKGKVTLGDSGVRPLEVFMCSIVRKMGYGEGFKWLSQYI............................................ 192
36 -23.300[U] KOG0090 Signal recognition particle receptor, beta subunit (small G protein superfamily)  ali follow..  21  57.........TVLLSGLSGSGKTVLFYQLRDGSSHQGAVTSMEPNEGTFVLTKKGKVKPVHLIDVPGHSRLISKLEEYLPRAAAVVFVVDALELPNIRAASEYLYDIASVIKNKTPVLLCCNKTDKVTAHTKEFIRKQMEKEIDKLRVSRSAISTADIANDFTLGI................................................ 221
37 -18.700[U] KOG3887 Predicted small GTPase involved in nuclear protein import  ali follow..  21  64.........RILLMGLRRSGKSSIQKVVFHKMSPNETESTNKIC--REDVSNSSF-VNFQIWDFPGQIDFFDPTEMIFRGTGALIFVIDSQDDEALARLHLTVTRAYKV-NTDINFEVFIHKVDGLSDQRANDDLADAGLEKIHLSFYLTSIYD-HSIFEAFSKVVQKLIPQLPT...................................... 243
38 -17.700[R] COG1084 Predicted GTPase  ali follow..  15  164.........TVVIAGFPNVGKSTLLRTLTGAEPEVADYPFTTKGIQIGHLERKWK--RIQVIDTPGNNIELQAMVALENIADVIMFIFDASETCGYTLESQYSLYLGIRSVFDIPVVTVFNKMDLAENVKYLEEYINMVED-----PLKVSAFEGRGVSKIIKKLEGLYEKETREAHDN.................................. 335
39 -16.800[R] KOG2486 Predicted GTPase  ali follow..  18  137.........EFALVGRSNVGKSSLLNSLVRRKRLALTSKKPG---KTQCINHFRINDKWYLVDLPGKQDWNKFTKDYFLNLVSVFLLVDASIPVK-LEYASWLGQ------NQVPMTLIFTKCDKRKKKKNGGKKPEANIKEFQ-PWIMTSSVTNQGRDEILLHMAQLR............................................ 312
40 -15.800[E] COG4917 Ethanolamine utilization protein  ali follow..  13  1.......MKRIAFVGSVGAGKTTLFNALQGNYTLARKTQAVEFN-------------DKGDIDTPGHPRWYHALITTLQDVDMLIYVHGANDPES-------LPAGLLDIGVSKRQIAVISKTDMPDADVAATRKLLLETGFEE-PMFELNSHDPQSVQQLVDYLASLTKQEEAGEKTHHSE............................... 159
41 -15.100[R] COG0218 Predicted GTPase  ali follow..  15  27.........EIALAGRSNVGKSSFINTMLNRKNLARTSGKPG---KTQLLNFFNIDDKMRFVDVPGREKWGCMIEEYLTTRRAVVSLVDLRHDPSADDVQ-----YEFLKYYEIPVIIVATKADKIPRGKWNKHESKKLNFDPSDDFILFSSVSKAGMDEAWDAILEKL............................................ 195
42 -14.700[R] COG3596 Predicted GTPase  ali follow..  10  40.........VIGIMGKTGAGKSSLCNALFAGEVSPVSDVA-ACTRDPLRFRLQIGEHFMTIVDLPGDTEYAALYREQLPRLDLILWLIKADDRALATDEHFYRQVIGEAYRHKMLFVI--SQSDKAEPTSGGNILSTEQKQNISRKVCAVSVRLQWGLRVMAERMIKCL............................................ 216
43 -14.000[R] KOG0410 Predicted GTP binding protein  ali follow..  19  309.......VPVVSLVGYTNAGKSTLLNQLTGANVLAENRLFATLDPTTRRVQMQNGK-EFLLTDTVG-AAFRA-TLEEIAESSLLVHVVDISHPLAEQQIEAVEKVMSELDVSSIPKLVVWNKVDR-----VDDPQKVKLEAEETGDTICISALTGEGLDDFCNAVHEKLKDSMVWVEA................................... 481
44 -13.700[J] KOG0462 Elongation factor-type GTP-binding protein  ali follow..  18  40.....DKIRNFGIVAHVDHGKSTLADRLLEGAVPPGQKQMLGITVKAQTAALRHRGYLLNLIDTPGHVDFSAEVSRSLAVCDGILLLVAANQ------QAQTIANFWLAFEKNIQIIPVINKIDLPGADKSVETQLKNLFEFNPEECLHISAKSGLNVDKVLEAIIDRV............................................ 211
45 -13.400[R] KOG1490 GTP-binding protein CRFG/NOG1 (ODN superfamily)  ali follow..  21  171..........VLICGYPNVGKSSFMNKVTRAD-----VDVQPYAFTTKSLFVG-KYLRYQVIDTPG-EMCSITALAHLRAAVLFFLDISGSCGYTIAQQAALFHSIKSLFMNKPLVIVC-NKTDLMPMENISEEDRKLIEESEEQVLLKMSTLTDEGVMSVKNAACERLLDQRVEAKMKSKKIND............................ 365
46 -13.300[M] COG0481 Membrane GTPase LepA  ali follow..  24  2.....KNIRNFSIIAHIDHGKSTLSDRLIQTC-SMDLERERGITIKAQSVTLDGETYQLNFIDTPGHVDFSYEVSRSLAACEGALLVVDAGQ------EAQTLANCYTAIEMNLEVVPILNKIDLPAADERVAEEIEDIVGIDAMEAVRCSAKTGVGIEDVLEEIVHKI............................................ 180
47 -13.300[R] KOG1489 Predicted GTP-binding protein (ODN superfamily)  ali follow..  19  332FLFELKSIADLGLIGLPNAGKSTILNKISNAKPKIGHWQFTTLSPTIGTVSLGFGQDVFTVADIPGASLDKGMGLEFLR-SNGWVFVLDLSNKNPLNDLQLLIEEVGTLEKKTKNILIVCNKVDIDAEKSAKYLQVEKFSKSQEWDCVPISALREKT........................................................ 499
48 -12.300[R] COG2262 GTPases  ali follow..  18  197.......VPTVSLVGYTNAGKSTLFNRITEARVYAADQLFATLDPTLRRIDVADVG-ETVLADTVG-AAFKA-TLQETRQATLLLHVIDAADVRVQENIEAVNTVLEEIDAHEIPTLLVMNKIDMLEDFEPRIDRDEENKPIR----VWLSAQTGAGIPQLFQALTERLSGEVAQHTL................................... 370
49 -12.200[J] KOG1191 Mitochondrial GTPase  ali follow..  22  354........LQIAIVGRPNVGKSSLLNAWSERAIVTEVAGTT--DVVEANVTVRG--VPITLLDTAGIRETNDISETAAKVADVIIMAVSAVEGWTEEDTESFYDLFGGLLYLKQPMILVMNKIDCAPPGSCDQLEDQRKKEEVFHKSVFTSAVTGQGIEELEDAILEIL............................................ 533
50 -11.300[OK] COG0378 Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase  ali follow..  11  4.......PLIIGVGGPVGAGKTMLIERLTRYLSTKGYSMAA-NFAAIEEMCDKHPDLQLLFLESGGD----LSATFSPDLVDFSIYIIDVAQGEKIPRKGGQGMIKSD--------LFIINKVDLAPYVGANVEVMKADTLKSRKDFFVTNLKTDEGLKSVADWIEKRLQLALLEE..................................... 206
51 -11.100[J] COG3276 Selenocysteine-specific translation elongation factor  ali follow..  16  1...........MIIVTSG-GKTALLKALTTAHLPEEKKRGMTIDLGYAYLPLENKVLGF---DVPGHEKF---LSNMLAGLGGVAMLIVAADEGVAVQTKEHLAILRQLQFHEIIVVI--TKADRTNSESLIQTIKQDYSFLRNANYFVTSAETGQGISELRHYLANLAELADTQK..................................... 169
52 -11.000[R] COG1159 GTPase  ali follow..  17  1MSTDKTYCGFIAIVGRPNVGKSTLLNKLLGQKISITSRKAQTTRHRIVGI-HTEGPYQAIYVDTPGNRLMNKAASSSIGDVELVIFVVEGTRWTPDDEM------LNKLRDGKAPVILAVNKVDNVQEKVDLLPHLQFLASQMNFLIVPISAETGMNVDTIAGIVRKHL............................................ 173
53 -11.000[P] COG0370 Fe2+ transport system protein B  ali follow..  18  4........NTYCILGNPNTGKTSLFNALTGSYEYVGNWS--GVTVEKKVGTLRSKTGKL-IYDLNPISRDETVVTRFLLEEK-MLNIVDSSQIERNLNLTVQLLEY------GAPVVMGLNMIDVAAGRGIHL-NIQNLAKKLRIPILPVVARSGKGTEDILSTLSEKHVAP......................................... 164
54 -10.900[TU] KOG1954 Endocytosis/signaling protein EHD1  ali follow..  18  95..........ILLVGQYSTGKTTFIRYLLESDFPGRALSGFGNAFLNRFSTLPNQVLEVTIVDTPGIDRFTGVLEWFAERVDRIILLFDAHKLDISDEFKRCIEALAGN-EDKIRIVL--NKSDMVDHQQLMRVYGA............................................................................ 269
55 -10.800[R] COG0486 Predicted GTPase  ali follow..  22  228........MKVVIAGRPNAGKSSLLNALAEAAIVTDIAGTT--DVLREHIHIDG--MPLHIIDTAGLREATDEAWSEIEQADRILLMLDSTEADN-QDLEKVRSEFLTKLPSNIPVTIVRNKADLSGENEGI-------VEQNGYTVITLSAKTQQGIALLREHLKQSMGYQTNMEG.................................... 395
56 -10.600[R] COG1160 Predicted GTPases  ali follow..  18  217.........KIAIVGRPNVGKSTLTNRILGED-RVVVFDMPGTTRDSIYIPMERDGQQYTLIDTAGVRKRGKVTLQAIQDANVVLLTIDARENISDQDLS-----LGFILNAGRSLVIVVNKWDGLDQDVKDRVKSELDRRLDFIDFARISALHGSGVGNLFDSIKE.............................................. 383
57 -10.500[J] KOG1145 Mitochondrial translation initiation factor 2 (IF-2; GTPase)  ali follow..  19  183..........VTIMGHVDHGKTTLLDKFRKTQVAAVETGGITQHIGAFLVSLPSGE-KITFLDTPGHAAFSAMRA---RGAQVTDIVVLVVAADD---MKQTVESIQHAKDAQVPIILAVNKCDKAEKKELLAYDVVCEDYGGDVQAVPVSALTGDNLMALAEATV............................................... 339
58 -10.400[J] KOG0468 U5 snRNP-specific protein  ali follow..  19  124LMDTPPLIRNVALVGHLHHGKTTFVDCLIRQTHPQFETMEEGCSIKATPVTLKQKSYLLNIFDTPGHVNFSDEATAAMRMSDGVVLFIDAAEGVMLNTERLL----KHAVQERQAITVCINKID......................................................................................... 263
59 -10.300[H] COG3172 Predicted ATPase/kinase involved in NAD metabolism  ali follow..  12  6.....FFVRTVAILGGESSGKSTLVNKLAN-IFNTTSAWEYGRDYVFSHLGGDEIALQYSDYDKIALGHAQYIDFAVKYANK--VAFIDAFCKKYEGREHPFVQALIDEYRFDLVILL--RSLGSSVDRKEFQNLLVEMLEENNIEFVRVE---EEDYDSRFLRCVELVREMMGEQR.................................... 187
60 -10.200[T] COG1217 Predicted membrane GTPase involved in stress response  ali follow..  16  3.....ENLRNIAIIAHVDHGKTTLVDKLLKLS-SNDQEKERGITILAKNTAIKWNGYNINIVDTPGHADFGGEVERVMSMVDSVLLVVDAQDGPMPQTRFVT----QKAFKAGLRPIVVVNKIDRPGAR.................................................................................... 136
61 -10.100[P] COG2895 GTPases - Sulfate adenylate transferase subunit 1  ali follow..  24  27.......LLRFLTCGSVDDGKSTLIGRLLVDGLQAEREQGITIDVAYRYFSTEKR--KFIIADTPGHEQYTRNMATGASTCELAILLID-ARKGVLDQTRRHSFISTLLGIKHLVVAI--NKMDLVDYSEETFTRAGQLPGNLDIRFVPLSALEGDNVAS..................................................... 215
62 -9.950[J] KOG0466 Translation initiation factor 2, gamma subunit (eIF-2gamma; GTPase)  ali follow..  18  42........INIGTIGHVAHGKSTVVKAISTVRFKNELERNITIKLGYANAKI-RLVRHVSFVDCPGHDILMATMLNGAAVMDAALLLIAGNESCPQPQTSEHLAAIEIMKLKHILILQ--NKIDLVKERQAKYEQILAFVQGEGAPIIPISAQLKYNIEVVCEYIVKKI............................................ 243
63 -9.680[J] COG4108 Peptide chain release factor RF-3  ali follow..  11  8YFGEVSKRRTFAIISHPDAGKTTITEKVLLFGRAIQVAGTVGISVTTSVMQFPYGDCLVNLLDTPGHEDFSEDTYRTLTAVDSCLMVIDAAKGVEDRTRKLM----EVTRLRDTPIVTFMNKLDREIRDPMELMDEVENELKIACSPITWPIGCGKEFKGVYHIHRDETI........................................... 193
64 -9.560[DZ] COG5019 Septin family protein  ali follow..  13  94......FNFNVLVLGESGSGKSTLVNTLLNRDVGVNPEPTVMINSSAVEIVENGISLQLNVIDTPG----------------------FIDNTDCWQPVLTDIEG-STIQDPRVHACIFFIQPTGHAISAMELRVMLALHEKVNI--IPIIAKADTLTDDELNFTKEMILRDIQYHNIR.................................. 270
65 -9.560[J] KOG0469 Elongation factor 2  ali follow..  17  12LMDRKRNIRNMSVIAHVDHGKSTLTDSLVSKA-TRKDEQERCITIKSTAISLKYNGFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDCVSGVCVQTETVL----RQAIAERIKPVLFMNKMDLQLGAEELFQTFQRIVENINVIIATYGDDDGPMGPIMVDPSIGNVG........................................... 224
66 -9.480[J] KOG0458 Elongation factor 1 alpha  ali follow..  19  168........LSFVVLGHVDAGKSTLMGRWIMDQTNEERERGVTVSICTSHFSTHRA--NFTIVDAPGHRDFVPNAIMGISQADMAILCVDCSTESGFDLDGQTKEHMLLASSLGIHNLIIANKMDNVDWSQQRFEEIKS--FEDNINWVPISGFSGEGVYK..................................................... 361
67 -9.430[DTZ] KOG1547 Septin CDC10 and related P-loop GTPases  ali follow..  16  279......FEFNIMVVGQSGLGKSTLINTLFKSKIEERIPKTIEIKSITHDIEEKGVRMKLTVIDTPGFGDHINNENCW-------IMKFINDQYEKYLQEEVNINRKKRIPDTRVHCCLYFIPATGHSLRPLDIEFMKRLSKVVNI--VPVIAKADTLTLEERVHFKQRITADLLSNGID.................................. 453
68 -9.410[J] COG0532 Translation initiation factor 2 (IF-2; GTPase)  ali follow..  19  448..........VTIMGHVDHGKTTLLDRFRESRVTEGEAGGITQHIGAYQIKANGKKITF---DTPGHEAFTSMRA---RGASVTDITILVVAADD---MPQTIEAINHSKAAGVPIIVAINKIDKPGANPQRVTQPVAWDPENGSEFVEISAKFNQNLDELLDTVL--LVAEVQELKADPTVRAIGT.......................... 624
69 -9.390[J] KOG0459 Polypeptide release factor 3  ali follow..  21  102........LNVVFIGHVDAGKSTIGGQYIMDTNEEERLKGKTVEVGRAHFETEST--RFTILDAPGHKSYVPNMISGASQADIGVLVISARKETGYERGGQTREHVQLAKTLGVSKLIVVNKMDDPTQKMVPFLKASGYNTKKDVVFLPISGLMGKNMDQ..................................................... 298
70 -9.330[J] COG5257 Translation initiation factor 2, gamma subunit (eIF-2gamma; GTPase)  ali follow..  18  5.........SEINIGLVG-GKTTLTKALSTDTHSEETKRGISIRLGYADITFRKLLRKVSFVDAPGHETLMATMLSGAALMDGAILVIAANEPCPQPQTKEHLMALDVIGVKDVIVVQ--NKIDIVSKERALYREIKEFVKGTDAPIIPVSAQQGANIDILIETIEERI............................................ 197
71 -9.320[F] COG1618 Predicted nucleotide kinase  ali follow..  13  3IEGKEKTMLRIAVTGSPGVGKSTVVAKTAEKLAEKPGFKIGG--IRTAEIRKEGHREGFSIRDLATGKTGILSHVKGSGPRLGLVVIDEIGPMELIS--QSFVSAVEEVLESDKPVLAVLHHSSRHPLAQRFRKGFEVL------------TVDKGNRDELPEKITNRFLRKLG....................................... 184
72 -9.150[DZU] KOG2655 Septin family protein (P-loop GTPase)  ali follow..  16  34......FEFTLMVVGESGLGKSTLVNSLFLTDLIEKQKQTVKLEASTVEIEERGVKLRLTVVDTPGDEQYERLNRRNIVDNRIHCCFYFIS--PFGHGLKPLDVEFMKKLHSKVNIVPVIAKADCLTKKEILKCRIMQEIESHGIKIYPLPDCDSDEDED..................................................... 221
73 -9.130[F] COG2019 Archaeal adenylate kinase  ali follow..  11  1........MRSVITGVAGVGKTTVLDIVARESGIPVVNYGTLMFEVAKRRGLVENRDQIRKLSRETQVDLQKLAGEEIGKMENAIVDTHMSIKTPFGYLPGLPEWVLRSINASVFVIIEADPAIIKRRREMNRYFAAAYSIFSGATVKIVKN-EEGKPEQAADEIVRVI............................................ 180
74 -9.110[S] KOG4308 LRR-containing protein  ali follow..  13  198..........IFILGDAGVGKSMLLQRLQSLWATGRLDAGVKFFFRCRMFSCFKESDRLCLQDLL-ERDPEEVFAFLLRFPHVALFTFDLHSDLDLSRVPDSSCPWEPAHPLVLLANLLSGKLLKGASKLLTARTGIEVPRQFLRKKVLLRGFSPSHLRAYARRLQDRLLSQLEANP.................................... 382

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Ye Y, Godzik A. Database searching by flexible protein structure alignment. Protein Sci. 2004 Jul;13(7):1841-50.