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Query: [T] KOG0099 G protein subunit Galphas, small G protein superfamily, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MGCLGNSKTEDQRNEEKAQREANKKIEKQLQKDKQVYRATHRLLLLGAGESGKSTIVKQMRILHVNGFNGEGGEEDPQAARSNSDGEKATKVQDIKNNLKEAIETIVAAMSNLVPPVELANPENQFRVDYILSVMNVPDFDFPPEFYEHAKALWEDEGVRACYERSNEYQLIDCAQYFLDKIDVIKQADYVPSDQDLLRCRVLTSGIFETKFQVDKVNFHMFDVGGQRDERRKWIQCFNDVTAIIFVVASSSYNMVIREDNQTNRLQEALNLFKSIWNNRWLRTISVILFLNKQDLLAEKVLAGKSKIEDYFPEFARYTTPEDATPEPGEDPRVTRAKYFIRDEFLRISTASGDGRHYCYPHFTCAVDTENIRRVFNDCRDIIQRMHLRQYELLLast
1 -121.000[T] KOG0099 G protein subunit Galphas, small G protein superfamily  ali  100  1MGCLGNSKTEDQRNEEKAQREANKKIEKQLQKDKQVYRATHRLLLLGAGESGKSTIVKQMRILHVNGFNGEGGEEDPQAARSNSDGEKATKVQDIKNNLKEAIETIVAAMSNLVPPVELANPENQFRVDYILSVMNVPDFDFPPEFYEHAKALWEDEGVRACYERSNEYQLIDCAQYFLDKIDVIKQADYVPSDQDLLRCRVLTSGIFETKFQVDKVNFHMFDVGGQRDERRKWIQCFNDVTAIIFVVASSSYNMVIREDNQTNRLQEALNLFKSIWNNRWLRTISVILFLNKQDLLAEKVLAGKSKIEDYFPEFARYTTPEDATPEPGEDPRVTRAKYFIRDEFLRISTASGDGRHYCYPHFTCAVDTENIRRVFNDCRDIIQRMHLRQYELL 394
2 -109.000[T] KOG0085 G protein subunit Galphaq/Galphay, small G protein superfamily  ali follow..  41  7MACCLSD-------EVKESKRINAEIEKQLRRDKRDARRELKLLLLGTGESGKSTFIKQMRIIHGAGYSEEDKRGFTKLVYQNIFTAMQAMIRAMETLKILY-----------------KYEQNKANALLIREVDVEKVTTFEHQYVSAIKTLWEDPGIQECYDRRREYQLSDSAKYYLTDVDRIATLGYLPTQQDVLRVRVPTTGIIEYPFDLENIIFRMVDVGGQRSERRKWIHCFENVTSIMFLVALSEYDQVLVESDNENRMEESKALFRTIITYPWFQNSSVILFLNKKDLLEDKIL--YSHLVDYFPEFDG------------PQREPQAAREFILKMFVDLNPD---SDKIIYSHFTCATDTENIRFVFAAVKDTILQLNLKEYNLV 359
3 -105.000[DT] KOG0082 G-protein alpha subunit (small G protein superfamily)  ali follow..  40  1MGSGISS-------ESKESAKRSKELEKKLQEDAERDARTVKLLLLGAGESGKSTIVKQMKIIHKNGYSEQECMEFKAVIYSNTLQSILAIVKAMTTLGIDY----------------VNPRSAEDQRQLYAMANTLEDGGMTPQLAEVIKRLWRDPGIQACFERASEYQLNDSAAYYLNDLDRITASGYVPNEQDVLHSRVKTTGIIETQFSFKDLHFRMFDVGGQRSERKKWIHCFEGVTCIIFCAALSAYDMVLVEDEEVNRMHESLHLFNSICNHKYFSTTSIVLFLNKKDIFQEKVT--KVHLSICFPEYTG-------------PNTFEDAGNYIKNQFLDLNLKKE--DKEIYSHMTCATDTQNVKFVFDAVTDIIIKENLKDCGLF 354
4 -19.600[U] KOG0077 Vesicle coat complex COPII, GTPase subunit SAR1  ali follow..  23  18.....................................QKEAKILFLGLDNAGKTTLLHMLK-------------------------------------------------------------------------------------------------------------------------------------DERLVQHQPTQHPTSEELSIGKIKFKAFDLGGHQIARRVWKDYYAKVDAVVYLV----------DAYDKERFAESKRELDALLSDEALATVPFLILGNKIDI.................................................................................................. 133
5 -19.200[R] KOG0075 GTP-binding ADP-ribosylation factor-like protein  ali follow..  27  18.....................................KEEMELTLVGLQFSGKTTFVNVIAS------------------------------------------------------------------------------------------------------------------------------------GQFAEDMIPTVGFNMRKITRGNVTIKVWDIGGQPRFRSMWERYCRGVNAIVYMVDAADLD----------KLEASRNELHSLLDKPQLAGIPVLVLGNKRDL.................................................................................................. 134
6 -18.800[U] KOG0070 GTP-binding ADP-ribosylation factor Arf1  ali follow..  30  15.....................................KKEMRILMVGLDAAGKTTILYKLKL-------------------------------------------------------------------------------------------------------------------------------------GEIVTTIPTIGFNVETVEYKNISFTVWDVGGQDKIRPLWRHYFQNTQGLIFVV----------DSNDRDRVVEARDELHRMLNEDELRDAVLLVFANKQDL.................................................................................................. 130
7 -18.700[R] KOG0074 GTP-binding ADP-ribosylation factor-like protein ARL3  ali follow..  28  15.....................................DQEVRILLLGLDNAGKTTLLKQLAS-------------------------------------------------------------------------------------------------------------------------------------EDISHITPTQGFNIKSVQSQGFKLNVWDIGGQRKIRPYWKNYFENTDILIYVI----------DSADRKRFEETGQELAELLEEEKLSCVPVLIFANKQDL.................................................................................................. 130
8 -18.700[U] KOG0071 GTP-binding ADP-ribosylation factor Arf6 (dArf3)  ali follow..  30  19.....................................NKEMRILMLGLDAAGKTTILYKLKL-------------------------------------------------------------------------------------------------------------------------------------NQSVVTIPTVGFNVETVTYKNIKFNVWDVGGQDKIRPLWRHYFTGTKGLIFVV----------DSADSNRISEARQELHRIISDREMRDCLLLVLANKQDL.................................................................................................. 134
9 -18.700[UZ] KOG0073 GTP-binding ADP-ribosylation factor-like protein ARL2  ali follow..  28  14.....................................ERELRLLMLGLDNAGKTTILKKFNG-------------------------------------------------------------------------------------------------------------------------------------EDIDTISPTLGFNIKTLEHRGFKLNIWDVGGQKSLRSYWRNYFESTDGLIWVV----------DSADRQRMQDCQRELQSLLVEERLAGATLLIFANKQDL.................................................................................................. 129
10 -18.600[U] KOG0072 GTP-binding ADP-ribosylation factor-like protein ARL1  ali follow..  24  15.....................................SREMRILILGLDGAGKTTILYRLQV-------------------------------------------------------------------------------------------------------------------------------------GEVVTTIPTIGFNVEQVTYKNLKFQVWDLGGQTSIRPYWRCYYSNTDAIIYVV----------DSADRDRIGISKDELLYMLREEELAGAILVVLANKQDM.................................................................................................. 130
11 -18.600[R] COG1100 GTPase SAR1 and related small G proteins  ali follow..  24  6...........................SSMFDKLWGSNKELRILILGLDGAGKTTILYRLQI-------------------------------------------------------------------------------------------------------------------------------------GEVVTTKPTIGFNVETLSYKNLKLNVWDLGGQTSIRPYWRCYYADTAAVIFVV----------DSTDKDRMSTASKELHLMLQEEELQDAALLVFANKQDQ.................................................................................................. 131
12 -18.300[U] KOG0076 GTP-binding ADP-ribosylation factor-like protein yARL3  ali follow..  19  15.....................................KEQYSILILGLDNAGKTTFLETLKKEYSLAFKA-------------------------------------------------------------------------------------------------------------------------------LEKIQPTVGQNVATIPVDSKQLKFWDVGGQESLRSMWSEYYSLCHGIIFIV----------DSSDRERLDECSTTLQSVVMDEEIEGVPILMLANKQDRQDRMEVQDIKEVFNKIAEHISARDSRVLPISALTGEGVKDAIEWMIVRLERNKKSRPPIYK..................................... 198
13 -14.000[T] KOG3886 GTP-binding protein  ali follow..  13  6.....SEKTTEKENLGPRMDPPLGEPEGSLGWVLPNTAMKKKVLLMGKSGSGKTSMRSII-----ANYIARDTRRLGATI--------------------------------------------------------------------------------------------------DRIHSLQINSSLSTYSLVDSVGNTKTFDVEHSHVRFGNLVLNLWDCGGQDTFMENYFTIFRNVEVLIYVF-----------DVESRELEKDMHYYQSCLEA---PDAKIFCLVHKMDLVQEDQRDLIFK--------------------------------------REEDLRRLSRPLECSCFRTSIWD-ETLYKAWSSIVYQLIPN........ 244
14 -12.400[U] KOG0090 Signal recognition particle receptor, beta subunit (small G protein superfamily)  ali follow..  15  51...................................RRTKSNTVLLSGLSGSGKTVLFYQLR-------DGSSHQGAVTSMEPNE--------------------------------------------------------------------------------------------------------------------GTFVLHNENNTKKGKVKPVHLIDVPGHSRLISKLEEYLPRAAAVVFVVDALEFLP---------NIRAASEYLYDILTNASVIKTPVLLCCNKTDKIRKQMEKEIDKLRVS--SFSHCHNKVTVAEASGLTGETDQVQEFIREHVK................................................ 259
15 -12.000[U] KOG3887 Predicted small GTPase involved in nuclear protein import  ali follow..  22  55................................DPFSTEVKPRILLMGLRRSGKSSIQK--------------------VVFHKM------------------------------------------------------------------------------------------------------------SPNETLFLE-STNKICREDVSNSFVNFQIWDFPGQIDFFDPTFMIFRGTGALIFVIDSQD-----DYMEALARLHLTVTRAYKV------TDINFEVFIHKVDGLSDDHK--------------------------------IETQRDIHQRANDDLADAGLEKIHLSFYLTSIYD-HSIFEAFSKVVQKLIPQ........ 240

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Ye Y, Godzik A. Comparative analysis of protein domain organization. Genome Res. 2004 Mar;14(3):343-53.