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Query: [S] KOG0295 WD40 repeat-containing protein, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MSLSERQKEEINRAIAEYMQNNGYSESFSVFLKESSLSENDIKPLGGILEKKWTTVLRLQRKVNDLESKLQESQREINHGAPTRDKRQAADWIPRPPETQKLTGHRLPITRVIFHPLWTIMASCSEDATIKVWDYETGQLERTLKGHTDAVNDIAIDAAGKQLVSCSSDLSIKLWDFGQTYDCLKSLKGHEHTVSSVTFLPTGDFVLSASRDHTIKQWDISTGYCVYTFRGHNDWVRMIRISNDGTLFASASLDQTVTVWSFATKSAKLVLRDHEHAVECVEWAPDTAYTNVTGQQPEGNSTHILFSGSRDRSIKAWNINTGDVLFTLLAHENWVRGLAFHPKGKYLISVADDKTLRVWELSAQRCMKAIEAHEHFVSTVAFHQTSPFVITGSVDMSCKVWECRLast
1 -96.000[S] KOG0295 WD40 repeat-containing protein  ali  100  1MSLSERQKEEINRAIAEYMQNNGYSESFSVFLKESSLSENDIKPLGGILEKKWTTVLRLQRKVNDLESKLQESQREINHGAPTRDKRQAADWIPRPPETQKLTGHRLPITRVIFHPLWTIMASCSEDATIKVWDYETGQLERTLKGHTDAVNDIAIDAAGKQLVSCSSDLSIKLWDFGQTYDCLKSLKGHEHTVSSVTFLPTGDFVLSASRDHTIKQWDISTGYCVYTFRGHNDWVRMIRISNDGTLFASASLDQTVTVWSFATKSAKLVLRDHEHAVECVEWAPDTAYTNVTGQQPEGNSTHILFSGSRDRSIKAWNINTGDVLFTLLAHENWVRGLAFHPKGKYLISVADDKTLRVWELSAQRCMKAIEAHEHFVSTVAFHQTSPFVITGSVDMSCKVWECR 404
2 -79.500[S] KOG0271 Notchless-like WD40 repeat-containing protein  ali follow..  24  1..................MTESPQISVSFVSEDENELGGSGILVPVDISTNELQILCQLLGSSDDPVPISFFTTEGAEIVDSIRKSLEEIRVRPVTRCSASIPGHGEPVISAQFSPDGRGLASGSGDQTMRIWDIELELPLHTCKSHKSWVLCIAWSPDATKIASACKNGEICIWNAKTGEQIGKTLKRHKQWITSLAWQPTCRLLASCGKDGNIFIWDTVQGTVVRCLSGHTASVTCLRWGGEGL-IYSGSQDRTVKMWRADDGVMCRNMTGHAHWINTLALNTDYAHMQLVNQVVFSPDTRYIASASFDKSVKLWCGRTGKYLASLRGHVGPVYQVAWSADSRLLVSGSADSTLKVFELKTKSLYYDLPGHGDEVFTVDWSPEGTKVVSGGKDKVLKLWR.. 472
3 -76.800[R] KOG0286 G-protein beta subunit  ali follow..  18  2..................................................GEMEQLRQEAEQLKKQIADARKACADVTLAEL--VSGLEVVGRVQMRTRRTLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNMCSIYNLKSRVKVSRELSAHTGYLSCCRFLDDNN-IVTSSGDTTCALWDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHESDINAICFFPNGE---------------AICTGSDDASCRLFDLRADQELICFSHESCGITSVAFSLSGRLLFAGYDDFNCNVWDSMKSERVGILSGHDNRVSCLGVTADGMAVATGSWDSFLKIWN.. 340
4 -75.300[D] KOG0642 Cell-cycle nuclear protein, contains WD-40 repeats  ali follow..  19  380........PSSSRLPEHEINRADEVEALTFPPSSGKSFIMGADEALESE---------LGPGELAGLTVANEADSLTYDIANNKDALRKTW-----NPKFTLRSHFDGIRALAFHPIEPVLITASEDHTLKMWNLQKTEPIYTFRAHKGPVLCVVMSSNGEQCYSGGTDGLIQGWNTTNPSVLRGPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWNTTEVAPALSVKELGIPASVDLVSSDPSHMVASFSKGYTSIFNMETQQRILTLENSSCQINRVISHPTLS---------------ISITAHEDRHIKFYDNNTGKLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRLWNLESKTCIQEFTAHEESIHDVAFHPSKCYIASAGADALAKVF... 779
5 -74.300[B] KOG0273 Beta-transducin family (WD-40 repeat) protein  ali follow..  20  139...................EATVNGEENGAHEINNHSKPMEIDGDVEI----PPNKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSEGGHDVPSNKDVTSLDWNSDGTLLAMGSYDGFARIWT-ENGNLASTLGQHKGPIFALKWNKKGNYVLSAGVDKTTIIWDA-HTGEAKQQFPFHSAPALDVDWQNNMT-FASCSTDMCIHVCRLGCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGP------ATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNTQSGSLVHSYQGTGG-IFEVCWNARGDKVGASASDGSVCVLDL. 522
6 -73.800[K] KOG0263 Transcription initiation factor TFIID, subunit TAF5 (also component of histone acetyltransferase SAGA)  ali follow..  18  228.........PMDKEMEKIVEMDLEEEDMMHQNDPNNQSPKLLKEFRKLHEPNAEDAPSRDYIPLPPHKGVDILSEVEAVKDWSKRLHLGPRASLPSVCMYTFHHTNNNMNCAEFSPDSTMIACGFQESYIRLWSIKDSDGSVRLLSHSGPVYGTTFSPDNKYLLSCSEDASARLWSV-DTKTALVAYKGHTGPVWDVAFGPFGHYFATASHDQTAQLWSCDHIYPLRVFAGHLSDVDCVTFHPNSAYVLTGSSDKTCRLWDVHRGHSVRVFNGHTQPVTAVAIAPDGHT---------------MASADSEGLIHLWDIGTGRRIKTMRGHRGNIYSLSFSRESTVLVSGGSDCTVRAWDVFKTNYNNPVSSSLTGSVVTPFSAKTSTFNEVNWSTS....... 612
7 -73.200[B] KOG0639 Transducin-like enhancer of split protein (contains WD40 repeats)  ali follow..  18  400...................QMSAAAAAAAVVAYGRSPMVGFDPPP--HMRVPTIPPNLAGIPGGKPAYSFHVTADGQMQPVPFPPDALIGPGIPRHARQINTLNHGEVVCAVTISNPTRHVYTGG-KGCVKVWDISHPGNKSDCLNRDNYIRSCKLLPDGCTLIVGGEASTLSIWDLAATPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQQH-DFTSQIFSLGYCPTGEW---------------LAVGMESSNVEVLHVNKPD-KYQLHLHESCVLSLKFAYCGKWFVSTGKDNLLNAWRTPYGASI-FQSKESSSVLSCDISVDDKYIVTGSGDKKATVYEV. 768
8 -73.200[A] KOG0306 WD40-repeat-containing subunit of the 18S rRNA processing complex  ali follow..  17  53.........RKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHKAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFLREKNLLVTSGKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRLITGASDSELRVWDIAYLRKAGSIMREGRDRVVNLAVDKTGRILACHGTDSVLELFCILSKKEIQTIGGHRSDVRTLSFSSDNIAVLSAAATGKLQLYDLASGNLLETIDAHDGALWSMSLSPDQRLDEDVLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKFFLSLYGHKLPVICMDISHDGALIATGSADRNVKIWGLDFGDCHKSLFAHDDSVMYLQFVPKSHLFFTAGKDHKIKQWDAD 663
9 -72.800[A] KOG0319 WD40-repeat-containing subunit of the 18S rRNA processing complex  ali follow..  19  173LNLYNIMRGAPKKLVNTWKSHNSHITALLQVPDSRVVVALSRDQTMKEFVIETAKLVRKKRIASSNLDHLAYDVVSNRFLAISAEQNLIILDFENLKIARQIVGHDEIYSCCLLGKDESHMAVASNTSEIRLYNTKTLDCQLIRGHTESVLSVVSPTWDTSLLASCSKDNSIIFWRLVTTLVPVAAATGHANTVTALAISNTGRFLASVSTDCTIKLWGLGKLTCSSTMVAHGKDVNCVDISESDALIATGGMDKLVKLWQVDTHKIAGTLSGHRRGVGDVKFAKNSH---------------KLASCSGDMTIKIWNISEKSCLQTISGHSCAVFRVIFARNDSQLISADSAGIIKIWTIKTADCECSIDAHTDKIWSLSKNHNESEFVTAGTDGRIVVWK.. 635
10 -72.100[A] KOG0291 WD40-repeat-containing subunit of the 18S rRNA processing complex  ali follow..  15  303................RKEQRDVQLTAANYNTRTKVLVVAFSSGAFYLYELPDVNMIHSLSISDYPISAALFNCTGDWVALASREGQLLVWEWQSEQYIMKQQGHSSEMTCIAYSSDGQFIATGGEDSKVKLWNTQSSFCFVTFSEHTSGVTGIQFSRNKKFLVSSSLDGTVRAFDVNRYRNFRTFTSPNPAQFSCVAVDYSGELVVAGGQDFDIFLWSVKTGKLLEIISGHEGPVVSIAFSPTSSTLVSGSWDKTVKIWNCLESNSEHETIDAVSDVTNVTFSPSGEQANYFSTIEYSADGECILAAGKSANICIYHVREAILLKKFEGLNDFISRKHLSEFGNMALVEEREVAIRLPGVQRGDMSSRRFQQEVRVFSVKFSPTGQAFAAAGTEGLCIYA... 752
11 -71.500[A] KOG0285 Pleiotropic regulator 1  ali follow..  18  57.GVEPASKPTRIADHNSEKTAPLKALALPGPKGSKELRKSATEKALVVGPTL-PPRDLNNTGNPGKSTAILPAPGSFLSTAALMERMPSRWPRPPWKNYRVLQGHLGWVRSVAFDPSNEWFCTGSADRTIKIWDVATGVLKLTLTGHIGQVRGLAVSNRHTYMFSAGDDKQVKCWDL-EQNKVIRSYHGHLHGVYCLALHPTLDVVLTGGRDSVCRVWDIRTKMQIFVL-PHDSDVFSVLARPTDPQVITGSHDSTIKFWDLRYGKSMATITNHKKTVRAMALHPKEN---------------DFVSASADNIKKFSLPKGEFCHNMLSLQRDIINAVAVNEDGV-MVTGGDKGGLWFWDWKSGHNFQRAETSEAGIYAACYDQTGSRLVTCEGDKTIKMWKED 456
12 -71.300[A] KOG0265 U5 snRNP-specific protein-like factor and related proteins  ali follow..  20  4.................................................KRPNNSVILAQEAKRSKNDLMAYTNRDKALLESGVRRTSNLQ-----APIMQLEGHEGEIFTAEFHPEGELLLSSGFDRQIYIWQVYEDENVMAMSGHSGAVMEAHFTPDGSHIFTCSTDKTLAFWDI-ATGQRQRRFKGHGNFVNSVQGSRRGQLLCSGSDDRTIKIWDARKKHAAHTLESPFQ-VTAVCFGDTGEQVISGGIDNEVKIWDIRKQAVLHHLRGHSDTITGMSLSPEGDF---------------ILTNAMDNTLRVWDVRGERCVKVFQGHEKNLLRCAWSPGSDKITSGSADRHVYIWDVNTRRILYKLPGHNGSVNAVDFSPKEPLILSGSSDKTLYLGEID 346
13 -71.200[U] KOG0276 Vesicle coat complex COPI, beta` subunit  ali follow..  17  4..........RLEIKRKLAQRSERVKSVDLHPTEPWILASLYSGTLCIWNYQTQVMAKSFEVTELPVRSAKFVARKQWVVAGADDMYIRVYNYNTMDKVKVFEAHSDYIRCVAVHPTLPYVLSSSDDMLIKLWDWEKGACTQIFEGHSHYVMQVTFNPKDNTFASASLDRTIKIWNL-GSPDPNFTLDAHQKGVNCVDYFTGGDYLITGSDDHTAKVWDYQTKSCVQTLEGHTHNVSAVCFHPELPIIITGSEDGTVRIWHATTYRLENTLNYGLERVWAIGYIKSSR---------------RVVIGYDEGTIMVK-LGREIPVASMDNTGKIIWAKHNEIQTANIKSIGADYEVTDGERLPLS-VKELGTCDLYPQSLKHNPNGRFVVVCGDGEYIIYTALA 383
14 -71.200[S] KOG0308 Conserved WD40 repeat-containing protein  ali follow..  16  24................HEYSNRSAVSALQYDAQNGRLFTGGSDTIIRTWSVPHHKDAGSLEQHTDWVNDMILCGHGKILISASNDTTVKVWNIERDNKIDCIRTHKDYVSCLAYAPIVEKAVSASFDHNIFVYDINANKTVNNLIGCKDSIYSLATTPNLSLVLGAGTEKCIRLFDP-RTNEKIMKLRGHTDNVRALVVNDDGTRALSAGSDATIRLWDIGQQRCIATCIAHEEGVWTLQVDSSFTTVYSAGKDKMVVKTPLYDFTKSQLLFKEEAPVKKLLLSEKDN-------------PVSLWVGTWKSDIKRWSIRPSAQLSIGGDEDGPSTSNANHSVSASSSPPVTFKYIRVKDQKGQQSTELVIPGAPAIKKHAMLSDKRHVLTRDSDGNVALYDV. 420
15 -69.500[Z] KOG0318 WD40 repeat stress protein/actin interacting protein  ali follow..  14  140.........ETGTSVGEISGQSKSINSADFRPARPRIVTGSEDNTIAVFEGPPFKFKMTKQDHSRFVQAVRYSPDGKFFASAGFDGKVFLYDGTSSELVGEFPAHKGGVYALAWKPDSTQLLTCSGDKTCRLWTVESRELVSEVMGTTVDDQQVSCLWQGDNLITVSLSGVITYLNVADPSKPLRVVKGHNKPITVLGLSDDRSTIYTGSHDGVVTNWNSGSGTND-RITGTGHGNQINGIAAWGDFVYTCGIDDSLRQFSVEGNSYTDYVVKLNCQPRGLAILRNENIKYEASSIAVNADTSDVAVGGDDQKLHIYTLKGGVLEKVELDHLGAVTDVSYSPDLKYLVACDAHRKVVLYSVEEYKPAHNWGFHSARVNTVAWSPNSLLVASGSLDTTIIIWSVA 563
16 -68.900[S] KOG0296 Angio-associated migratory cell protein (contains WD40 repeats)  ali follow..  16  2.........AEEEENQELYIAENEVEEVKLMDQGVTEDEAEQEQNDTMNNMVMDMSVQGFFEHKDSVFSVSINPVHNLCASGGGDDLGYIWDITTGEQICQLTGHKDSIVAIDWSFDGTYIATGGMDSQVRLWKSSTGFEFITAFETVDEIVWLSWHPKGLFLAAGCNDGSIWMWSLP-SGKVVQVMYGHTAPVNAGKFIPPGKRLATVDDSGTLIVWNPATGAPECRMSETAAGWTSFDCNAEGNVLFLGGSSGKVKVVNINSSHILASLEAQTESVEAIALCTALP---------------ICACASVDGTVALYDSASLKFRKSL-PHEQAVIDCKFLPNTPYLLTACADCVIRKWDVRSGQLLGEYTGHQEPILCMAITPDGKRVVTGSDDTELLVFDCE 398
17 -68.800[R] KOG0288 WD40 repeat protein TipD  ali follow..  18  136.........EIRSQLEEMTSRVQKAETENKMLIDRWMLQKMQD--AERLNEANDLYEEMLAKLKANGLETLARQQVDGIVRRNEDGTDHFVESTPSTCANRIHAHEGGCGSIVFEYNSGTLFTGGQDRAVKMWDTNSGTLIKSLYGSLGNILDMAVTHDNKSVIAATSSNNLFVWDV-SSGRVRHTLTGHTDKVCAVDVSKFSRHVVSAAYDRTIKLWDLHKGYCTNTV-LFTSNCNAICLSIDGLTVFSGHMDGNLRLWDIQTGKLLSEVAGHSSAVTSVSLSRNGNR---------------ILTSGRDNVHNVFDTRTLEICGTLRASGNRLASSCISPDDDYVAAGSADGSVHVWSLSKGNIVSILKEQTSPILCCSWSGIGKPLASADKNGYVCTWT.. 515
18 -68.700[R] KOG0315 G-protein beta subunit-like protein (contains WD40 repeats)  ali follow..  13  1............................MGDQQQLILATGGYDHTIKVWQAHTGNCIKTMRVETSQVNALDRTPDKTRLAACGYQ-CIRLYDLESNCPVINFDGVQKNVTRLGFQEDGNWMFTAGEDHHVRIWDMIAAPHCSRIFDCEAPVNAACLHPNQVEIAMGSQNGSVFLWDV-KSERHERIVPEVDASIQDVAISPDGRYLAAANNKGNCYIWSLTSQRPNRKIPAHSRYILRCKFSPDSRLLLTTSGDGTVCIWKTDDFSKWRELCIENYWVWDAAFSADSKW---------------LFTASSDGIARLWKLQTKSSIRDYTGHTKAITALSFKDEIPVKSTNISDVQSSAKPPT------QRDNPPGTNNLAFFETVGRVAMNPYMGNTTTELN.. 362
19 -68.300[D] KOG0267 Microtubule severing protein katanin p80 subunit B (contains WD40 repeats)  ali follow..  19  2..........................................................SLCGHTSPVDSVAFNSEEVLVLAGASSGVIKLWDLEESKMVRAFTGHRSNCSAVEFHPFGEFLASGSSDTNLRVWDTRKKGCIQTYKGHTRGISTIEFSPDGRWVVSGGLDNVVKVWDL-TAGKLLHEFKCHEGPIRSLDFHPLEFLLATGSADRTVKFWDLETFELIGTTRPEATGVRAIAFHPDGQTLFCGLDDG-LKVYSWEPVICRDGVDMGWSTLGDF----------------CINEGKFIGCSYYRNSVGIWVSDISELEVSEDKNECMVKRFSVLNDQSERMGSGPRGSV------------SPDYETREIKNIYVDSTGGNLNVAQNPGSLKATLPL 321
20 -68.000[S] KOG0282 mRNA splicing factor  ali follow..  21  155...........SVEEAEKNQGLTVFETGQKKTEKRKKFKENDASNIDGFLGPWAKTILHVKEMYDYQGRSYLHIPQDVGVNLRSTMPPEKCYLPK-KQIHVWSGHTKGVSAVRLFPLGHLLLSCSMDCKIKLWEVYGRRCLRTFIGHSKAVRDICFNTAGTQFLSAAYDRYLKLWDT-ETGQCISRFTNRK-VPYCVKFNPDEDLFVAGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRVWEWDIPVDFKYIEPSMHSMPAVTLSPNGKW---------------LACQSMDNQILIFGAQNRFRLNKKKMVAGYACQVDFSPDMSYVISGDGNGKLNIWDWKTTKLYSRFKAHDKVCIGAVWHPETSKVITCGWDGLIKLWD.. 579
21 -68.000[T] KOG0279 G protein beta subunit-like protein  ali follow..  21  2..................................................AEGLVLKGTMCAHTDMVTAIATPVDNSVIVTSSRDKSIILWKLTKGVAQRRMTGHSHFVQDVVLSSDGQFALSGSWDGELRLWDLATGESTRRFVGHTKDVLSVAFSTDNRQIVSASRDRTIKLWNTGECKYTISEADGHKEWVSCVRFSPNTLVIVSASWDKTVKVWNLQNCKLRNTLAGHSGYLNTVAVSPDGSLCASGGKDGVILLWDLAEGKKLYSLEAG-SIIHSLCFSPNRY----------------WLCAATENSIRIWDLESKSVVEDLKVD---LKAEAEKTDGSTGIG--------------------NKTKVIYCTSLNWSADGNTLFSGYTDGVIRVWGIG 324
22 -67.500[S] KOG0316 Conserved WD40 repeat-containing protein  ali follow..  17  1.............................................MSATELP-TKEAHILKGHEGAVLAARFNGDGNYALTCGKDRTIRLWNPHRGILIKTYKSHGREVRDVHVTSDNAKFCSCGGDRQVYYWDVSTGRVIRKFRGHDGEVNAVKFNDSSSVVVSAGFDRSLRVWDC-RSHSVEPVQIIDTFLDTVMSVVLTKTEIIGGSVDGTVRTFDMRIGREMSDNLGQP--VNCISISNDGNCVLAGCLDSTLRLLDRTTGELLQVYKGHIS-------------KSFKTDCCLTNSDAHVIGGSEDGLVFFWDLVDAKVLSKFRAHDL-VNSIDVDFYLRKFFVAGDKRELPPEGRLYVDFFGRWYNSLEKMKKQQILTSIDFVIYVSNSPFFFYYRL. 343
23 -67.500[A] KOG0272 U4/U6 small nuclear ribonucleoprotein Prp4 (contains WD40 repeats)  ali follow..  20  148ICYFGEGPAERRRRLKELLAGLGENAINKRQYEDEERKQQQREQDQATWYHEGPDSLRADYSLPRAKDRLVRAREALEVPSAARAGRMVEKKLQSLAPLCSQVGDTRPVSSAAFSEDSSLLLTSSWSGLCKLWSVPDCELKQTLRGHASYVGGVALRPGVKAMASGGHDGAVKLWGF-NNEESIADITGHPHRVSKVAFHPSGRFLATACYDSSWRLWDLEQKTEVLHQEGHAKPVHCLSYHSDGSVLVTGGLDAFGRVWDLRTGRCIMFLEGHLGAVFGVDFSPNGFH---------------IATGSQDNTCKIWDLRRRQPVYTIPAHTNLISDVKYQQEGSFLVTCSYDSTTKIWSNKTWQPLKTLQGHDNKVISVDIAPNSQYIATTSFDRTFKLWSPD 552
24 -66.400[A] KOG0640 mRNA cleavage stimulating factor complex; subunit 1  ali follow..  18  26...............LMYDGLEKFAMELSMLVKADQCAPSERLLHVMIAGMQTSDKDKTNSDDVLPGIDLEFEPEASALAPEPHSYETA-----------YVTSHKQACRAGAFSCDGSLVATGSVDASIKILDVERMPVIRTLYDHTDEVSYLEFHPKEHILASASRDGTVKLFDIAKPSKKAHKVFTDCEPVLCLSFHPTGDYVAIGTEHNVLRVYDVATTQCFVSAQQHKAGVTCVKYSPTGKLYATGSYDGDIKIWDGISGRCINTIAEAHGAICSLEFTRNGKY---------------LLSSGMDSLVYLWELCTSRPIQTYTGQEHQTEAVFNHTEDYVLFPDEATTSLCSWNSRNGCRLTNSLGHNGPVRYITHSPNGPAFLTCSDDFRARFWYRR 420
25 -65.700[S] KOG0772 Uncharacterized conserved protein, contains WD40 repeat  ali follow..  17  20LQAMFAQTISNAPRTEEPTHVPQSVSVSSKSESGVSSSAVSDDEDDFMPDLPPGF--QMQQSEAGPSSSRAEGPEDSDDSDFDETEAISIIKLIPAACEAKISHGTQAISALRVEPPGVRFASGGLDYYVKLFDFQKMDMSELLPAESHVINSLAFSPNGETLVVASGEAIIRLLDRAGK-IDLNITKGHTATVNCVEFNPLNKEFISCSDDGSLRLWNLDDHKVIKGANGKRVSPQVCTFSPDGKWIAAGCDDGSVQAWKYGSQYVYLVRKAHNGSITSIAFSPDSK---------------RLLSRGFDDTLKMWSLDNPKLVKTGLENAFKSTDCGFSPRAEVVFTGDTPGTLQFFDPMTFDLVYKIDYPGISCHRIQWHPRLNQIIAGLSDGTIHVYYDQ 448
26 -65.600[BK] KOG1063 RNA polymerase II elongator complex, subunit ELP2, WD repeat superfamily  ali follow..  18  164............VCLDSICVDTKAIVTLSLNPGRFALALGGLDNKIKLYSGERTTSVCELKGHTDWIRSLDFSLPLHMLVSSSQDKVIRIWKLVLVGDVSVLIGHEDWVYSVEWQPPVISILSASMDKTMMIWRPEKKTCVGELSHCALGFYGGHWSPNSLSILAHGYGGAFHLWRNVSNWQMQKVPSGHFAAVTDVTWARTGEYLLSVSQDQTTRVFSAWKNDARPQVHGHDINCVAMVQGKGNHRFVSGAEEKVVRVFEAPLSSEPLERNGGGEGLDTFETVPEAAHGNELFSLCSDHKGNLVASSCKAQSIWLWEVGTWKAVGRLQSHSLTVTHLEFSYDDTLLLSVSRDRHFSVFSIQRTKLMAKVEAHKRIIWACSWNPFGHQFATSSRDKTVKIWSVE 726
27 -65.500[R] KOG1539 WD repeat protein  ali follow..  14  140...............LQLTGKFTPTSIVHPDTYLNKVLVGSQEGPLQLWNINTKKMLYQFKGWGSSVTSCVSSPALDVVAIGCADGKIHVHNIKLDEEIVTFEASRGAVTALSFSTDGRLLASGGSFGVISIWNLNKKRLQSVIDAHDSSIISLNFLANEPVLMSASADNSLKMWIFDTNPRLLRFRSGHSAPPLCIRFYSNGRHILSAGQDRAFRLFSVIQEQQSRELNHLLLAILACAISACGNFAVVGTAGGWIERFNLQSGISRGSYYAHDGEVIGVACDSTNTLMISLVKIVYHRVNGLLATVADDFVIRLYDVVTLKMVREFRGHTDRITDLCFSEDGKWVISSSMDGSLRIWDVILAKQIDGV-HVDVPITALSLSPNMDVLATAHSDQNVYLWVNQ 650
28 -65.000[R] KOG0289 mRNA splicing factor  ali follow..  18  125........TAAREALATLKPQAGLIVPQAVPSSQPSVVGAGEPMDLGELVGMTPEIIQKL-QDKATVLTTERKKRGKTVPEELVKPEELSKYRQVASHVGLHSASIPGILALDLCPDTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSV-PNASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYY---------------LATAADDSSVKLWDLRKLKNFKTLQDNNFEVKSLIFDQSGTYLALGGTD--VQIYICKQWTEILHFTEHSGLTTGVAFGHHAKFIASTGMDRSLKFYSL. 504
29 -64.800[J] KOG0650 WD40 repeat nucleolar protein Bop1, involved in ribosome biogenesis  ali follow..  15  343........AESYNPPPEYLFDAKETKEWLKLKDEPHKRKLHFMPQKFKSLREVPAYSRYLRERFLRCLDLYLCPRAKRVKLNIDAEYLIPKLPSPRDESMVYRGHTDLVRSVSVEPKGEYLVSGSDDKTVKIWEIATGRCIRTI-ETDEVVRCVAWCPNPKLIIAVATGNRLLLVNPKEQEKGVRVVITHFKPIRQVTWHGRGDYLATVMPEGANRIHQLSKRRSQIPFSKSKGLIQFVLFHPVKPCFFVAT-QHNIRIYDLVKQELVKKLLTNSKWISGMSIHPKGDN---------------LLVSTYDKKMLWFDLDSTKPYQTMRLHRNAVRSVAFHLRYPLFASGSDDQAVIVSHGMVYNPLKKLQTHEKRVLDVNWHPVQPWVFSTGADSTIRLYT.. 784
30 -64.300[A] KOG0284 Polyadenylation factor I complex, subunit PFS2  ali follow..  16  81...........HCENRLWQYGKQRILQQPDILYQQYAVPADSTPDVPVDCILTKFIRTAMNKVKCPVYSVCWSPEGKRLITGCQTGEFTLWNGTAFNFETILQAHDSAIRALKWASNEQWLLSADQGGYVKYWQPNMNNAHMFSAHKDEAIRGLAFAPTDVKFATASDDGTARVWDF-ARYTEERVLRGHGAEVRCIDWHPTKGLIATGSRDTPVKIWDPKSGSCLATLQEHKSSVMAVEFNKNGNWLLTGGRDHLVKMYDIRMMKEMRTYRAHKKEVISLAWHPIHE--------------GLFVSGGGDGSIVYWMVDGEKEIGLLHAHDQAIWSMKWHPLGHILATGSNDNNTKFWARNFGLSNTNMIGHLDKEREPRMAPPKPSIETQETYRPDTFIPG. 469
31 -64.200[R] KOG0645 WD40 repeat protein  ali follow..  19  1............................................................SGHTGRLWSVAAHPMLPLFATSSQDKSVRIYNSNTYNLVHVIDGHTRSIRRVAWRPIERVLAVASFDSVVSINEKDDWECTAALEGHENEVKCIAWSCNGNYLATCSRDKSVWIWEATEEFDCLAVLQEHTQDVKVVTWHPTEDLLVSGSYDNSICFWDGDDWALTCQLQGHTNTVWALAFSPNGNTLASADNDGNVFLWIKISSNEDVATIDSTNILRPALQEE-----------------------------------WKQQTSLPHIHKGAVYTISWMNDAT-LCSAGGDGKIVVYQREKHDYEQDHAHGVYEINSLEYLRDDR-LLSGGDDGECRVWSFK 322
32 -64.000[JT] KOG0643 Translation initiation factor 3, subunit i (eIF-3i)/TGF-beta receptor-interacting protein (TRIP-1)  ali follow..  16  5..........................................................LLQGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDADWDTKHVLTGSADNSCRLWDCETGKQLALL-KTNSAVRTCGFDFGGNIIMFSTDKQMVSFFDLRDNNEPYMKIPCNDSKITSAVWGPLGECIIAGHESGELNQYSAKSGEVLVNVKEHSRQINDIQLSRDMTMFVTASKDNTAKLFDSTTLEHQKTF-RTERPVNSAALSPNYDHV-VLGGGQEAMDVTTTSTRIGKFEARFFHLAFEEEFGRVKGHFGPINSVAFHPDGKSYSSGGEDGYVRIHYFDPQYFEFEFEA................................ 325
33 -63.800[R] KOG2096 WD40 repeat protein  ali follow..  16  2..........................DSVLVVGIASVILGALIAVLFFGSYFRKRTSEVQSMAKAEPQDPIRNPKSNHPAPKKNHPKSQASDKNQNKDLNTLKGHGDAVTGLCFSSDGKSLATACADGVIRVFKLDDARFLRINLPAGGHPTAVAFADDASSIVVACHHMSSIKWDH-HHIHEKRSVLTISGATATYGTADGSVVIASCSEGTDIVLWHGKTGRNLGHVDTNQLKNHMAAVSPNGRFLAAAAFTADVKVWEIVYQKRVMQLKGHKSAVTWLCFSPNSEQ---------------IITASKDGSIRVWNINVRYPLCDSGGNPLHYDRLSLCPEGKILAASH-GSTLQWLCAETGNVLDTAKAHEGDITCISWAPKAMVLGTSGDDKKVKLWEAP 449
34 -63.300[S] KOG0293 WD40 repeat-containing protein  ali follow..  16  231...................SLHIQRDSCVFHNTLDSDLSLYSDHQCGKHQIP-SQTAQILESHTDEVWFLQFSHNGKYLASSSKDQTAIIWEISADSLKHTLVGHHKPVIAILWSPDDRQVLTCGAEEVIRRWDVDSGDCVHMYEKGGISPISCGWYPDGQGIIAGMTDRSICMWDL-DGREKECWKGQRTQKVSDIAMTDDGKWLVSVCKDSVISLFDREATV--ERLIEEEDMITSFSLSNDNKYILVNLLNQEIRLWNIEGDPKISRYKGHKRSRFIIR------------SCFGGYKQAFIASGSEDSQVYIWHRSTGKLIVELPGHAGAVNCVSWSPTNLMLASASDDGTIRIWGLDRINQQNQKKVQGSSSNGVIHRCNGN................. 589
35 -63.300[A] KOG1272 WD40-repeat-containing subunit of the 18S rRNA processing complex  ali follow..  13  1...........................MEISSEDNNLMEKVLPPVEQVLTWTLIQICMQESDVELETKVKKYLRGEGANLETLKDKKLKTQLASREKLYGKSAKAAAKIEKWLLPAEAGYLETEGLEKTWRVKDILSSRNQYDIVLPDFGPYKLDFTASGRHMLAGGRKGHLALLDMMNMS--LIKEIQVRETVRDVAFLHNDQFFAAAQKKYAYIYGR--DGTELHCL-KERGPVARLRFLKNHFLLASVNMSGQLHYQDVTHGGMVASIRTGKGRTDVMEVNPYNS---------------VVGLGHSGGTVTMWKPTSQAPLVQMQCHPGPVSSVAFHPNGHLMATSGKERKIKIWDLRKFEEVQTIHVKGYQIEKVMFRPYEDVIGIGHSMGWSSILIPG 410
36 -62.900[S] KOG0281 Beta-TrCP (transducin repeats containing)/Slimb proteins  ali follow..  22  141DPLWKGLSESRGWDQYLFKNRPTDGPPNSFYRSLYPKIIQDIETIESNWRCGRHN-LQRIQCRSENSKGVCLQYDDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQY--DERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSNGL--MVTCSKDRSIAVWDMASDITLRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQY--RDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRF-----------------DNKRIVSGAYDGKIKVWDLQSTLCLRTLVEHSGRVFRLQF--DEFQIISSSHDDTILIWDFLNVPPSAQNETRSPSRTYTYIS..................... 507
37 -62.500[S] KOG1407 WD40 repeat protein  ali follow..  22  2...................................................................................EETTIPFK----SLHSREYQGHKKKVHSVAWNSNGTKLASGSVDQTARIWNIESKAKDLELKGHTDSVDQLCWDPKHSLVATASGDKSVRLWDA-RSGKCTQQV-ELSGENINITYKPDGTHVAVGNRDDELTILDVRKFKPLHRR-KFNYEVNEIAWNMPGDFFFLTTGLGTVEVLSYPSLKPLDTLTAHTAGCYCIAIDPKGRY---------------FAVGSADSLVSLWDISDMLCLRTFTKLEWPVRTISFNYSGEYIASASEDLFIDIANVQTGRTVHQIPCRAA-MNSVEWNPKYNLLAYAGDDKNPKYNT.. 302
38 -62.100[R] KOG2394 WD40 protein DMR-N9  ali follow..  11  121........SSRISGSFAASNSNTSMTNTNFDGKGTYLVFNVSDAFICDLNSQEKDPVKSIHFSNSNPMCHAFAKDGHDLLIGLNSGDVYTVSLRQQNKDGSVNNRQDRCTSISWVPSTFPAIRDPTQFSVDKAKYSKSNPVARWHICQGSINSIAFSNDGAHLATVGRDGYLRIFDF-LTQKLVCGGKSYYGALLCCSWSMDGKYILTGGEDDLVQVWSMEDRKVVAWGEGHNSWVSGVAFDSNWSRFGSVGQDTQLLLWDLEMDEIVVPLRRAPGGSPTYSTGSSAHWDNVI------------PMGTLQPAPCKRDVPKLSPIIAHRVHTEPLSGLMFTQES--VVTACREGHIKIWTRPSEQTNSSEANPTTALLSTSFTKDNKASLSSKIISGSTFKQ.. 556
39 -61.600[ABO] KOG1446 Histone H3 (Lys4) methyltransferase complex and RNA cleavage factor II complex, subunit SWD2  ali follow..  17  2......................................................................................KIKLIDVRSFKVAKIFRENTDKINAIDFAPNGEHLISCSEDDQIVIYDCEKGTQSRTVNSKKYGVDLIHFTHANNTASSTKVDDTIRYLSL-HDNKYLRYFPGHTKKVISLCISPVEDTFLSGSLDKTLRLWDLRSPNCQGLMHLSG--RPIAAYDPEGLIFAAGVNSESIKLYDLRSFDTFKLNQEKECDWTGLKFSRDGKT---------------ILISTNGSVIRLVDAFHGTPLQTFTGYPNIPIEASFSPDSQFIFSGSTDGRVHIWNADTGNKVSVLNGHPGPVQCVQFNPKYMMLASACTNMAFWLPTSE 314
40 -60.600[R] KOG1524 WD40 repeat-containing protein CHE-2  ali follow..  12  2.........KLKLSASRKTRHTEMVCGVGWIGTEA-ILSAADDHVFLLTNTATNESQQILNMPETFFRSQTKGGQNDVFAVSTSDGKINILS-RNGKVENMVDAHNGAALCARWNSDGTGLLSSGEDGFVKMWSRSMQVAPIKWKAHDGIILCCDWNPTSDLIVTGGEDLKFKVWD--GFGQILFNSSVHDYPITSISWNTDGTLFAVGSHN-ILRLCD-KSGWSHSLEKMNAGSVMALSWSPDGTQLAVGTAAGLVFHAHIIDKRLTNTPTMIEYNERTVNIIVQCEALLDERKIDLANDTLVVRDRADNKVLHFFDPTTGKAQGDNLKHEHDIVELTVNQCGRNVAFRDQIGAVHIAMVKTFGVSQRMVKIGSLVEQLVFNDVTNMLCGIS-EGKIAVWP.. 531
41 -60.600[S] KOG0283 WD40 repeat-containing protein  ali follow..  16  310....................EPLMDLRKFNSYLSKSVRLSKRRGAALLKNIKAHSMSLRVADKDVSDGSTDSPKKGKDHKHGKANEWVKVRELSALHMCQEIQAHEGAVWTIKFSQDAHYLASGGADRVIHVWEVQECELMSMNEGSLTPIHPSLCDSSGNEITVVEKKKKGKGSSGRRSDKPVCSLKGHLDAILDLSWSKSQL-LLSSSMDKTVRLWDIETKTCL-KLFAHNDYVTCIQFSPDENYFLSGSLDAKIRIWSIQDRH-VVEWSDLHEMVTAACYTPDGQG---------------ALIGSHKGICRAYDTEDCKLSNKKSQAKRKITSFQFSPVNPEVLVTSADSRIRILDGSEVIHKFKGFRNTCSQLSASYSQDGKYIICASEDSQVYLWKND 712
42 -60.100[S] KOG1409 Uncharacterized conserved protein, contains WD40 repeats and FYVE domains  ali follow..  10  2.................................AAIINQRVEQGESSMGGAK-PALLHRITGHVARINDVILLSKDEGVWTASDDRSVRLYLKRDNDQFWPSHFMPVAPTSLYYSEETYKLLVGLINGNVYEFDFNSMTESRKWTCHAGPISGLGFALSSELIFSCSRDKSIVWHCSENS----NKMGSYLLENSCTAMVIDLPFVFVGDHGGHVTVLRIVDNQLVSKLSAHTNAITSLTWDGNKKVLYSGSSDHLIIMWDIGGGRGEYELNGHNGKVTTLCAAPAAKR---------------LFSADEHGKLMCWDMNCKRVETPEWKTSDCCQKCSCCDNWTTYPPMGYETKIRICNNFNLTPLAIPHEIHTGITAMHLQETLGLLVTSGQNRVIMIWDVR 405
43 -60.100[A] KOG0268 Sof1-like rRNA processing protein (contains WD40 repeats)  ali follow..  14  55..........AKPFLASLDGHRDGVNCLAKHPEKLAVLSGACDGEVRIWNLTQRNCIRTIQAHEGFVRGICTRFCGTSFFTVGDDKTVKQWKMDGPDEEEPLHTILGKTVYTGIDHHWKEAVFATCGQQVDIWDEQRTNPICSMTWGFDSISSVKFNPIETLLGSCASDRNIVLYDMRQATPLKKV--ILDMRTNTICWNPMEAIFTAANEDYNLYTFDMRADTPVMVHMDHVSAVLDVDYSPTGKEFVSASFDKSIRIFPVDKSRSREVYTKRMQHVICVKWTSDSKY---------------IMCGSDEMNIRLWKANASEKLGVLTSREKAAKDFQHYPHIKRIARHR-HLPKSIYSQIQEQRIMKEARRRKEVNRIKHSKPGSVPLVSEKKKHV-VAVVK 445
44 -59.800[U] KOG0277 Peroxisomal targeting signal type 2 receptor  ali follow..  26  2...........................................................................................SAVCGGAARMLRTPGRHGYAAEFSPLPGRLACATAQGTLLILDPEAGLRLFRSFDWNDGLFDVTWSENNEVLITCSGDGSLQLWDTAKAAGPLQVYKEHAQEVYSVDWSQTRGLVVSGSWDQTVKLWDPTVGKSLCTFRGHESIIYSTIWSPIPGCFASASGDQTLRIWDVKAAGVRIVIPAHQAEILSCDWCKY--------------NENLLVTGAVDCSLRGWDLRNRQPVFELLGHTYAIRRVKFSPHASVLASCSYDFTVRFWNFSKPSLLETVEHHTEFTCGLDFSLQSPQVADCSWDETIKIYDPA 317
45 -59.700[Z] KOG1523 Actin-related protein Arp2/3 complex, subunit ARPC1/p41-ARC  ali follow..  13  1........................................................MSLHQFLLEPITCHAWNRDRTQIALSPNNHEVHIYKKNGSQKAHELKEHNGHITGIDWAPKSDRIVTCGADRNAYVWSQKDGKPTLVILRINRAATFVKWSPLENKFAVGSGARLISVCYFEAENDSKHIKKPIRSTVLSLDWHPNNVLLAAGSCDFKCRVFSAYIKESEFGGSGTGGWVHGVSFSASGSRLAWVSHDSTVSVADASKSVQVSTLKTEFLPLLSVSFVSENS----------------VVAAGHDCCPMLFIYDDRGCLTFVSKLDIPKQSIQRNMSAMERFRNMDK-----RATTEDRNTALETLHQNSITQVSIKQDCRKFCTTGIDGAMTIWDFK 358
46 -59.400[A] KOG0299 U3 snoRNP-associated protein (contains WD40 repeats)  ali follow..  16  72LRLAREYLDEVKNELVE--DGGFDAKEVDRELLASRLKEDVLEKTSKINPDVKIETAQLRGRHMRPLVGVVAYENF--VYSADKSGLIQKWEALQEKDTENRNDHVKEITCLAISNDGRWIVTGGLDHRIVIRDSVTLEPQHCWKHHRDAVMGLAMRRGTNEMFSCSADRSIKVWSL-DQMSYIETLFGHQDVIFGVDALARERCVSVGGRDRTSRLWKIVEESQLKATAGYMEGSVDCVAMIDEDHFVTGSDNGVIALWSVQRKKPLFTYPLAHGLDPILAPGRHSAQPRWITSLAAIPYSNLFASGSWDGNIRLWKIAEGLRSATPLSVYGCINSLSLSLQGKVFAACGRETRVGRWKTLRGIPNSGF-VFNIPLTVIPSVTDGDEIDE............. 524
47 -59.200[T] KOG4378 Nuclear protein COP1  ali follow..  16  1..................................................................MMSNLVEPSWRLLAASGGD-TVKLFDVSADSVLSYTPSPGCAVNSVKWNHTNLVVASTGEDKKISLWRKNGQSLGTGGDSAEECLSAISFSKKGRYICSGGTGQIVKIWDL-QRKLCIKKLKGHTSTITGVMYNCKDEHLASVSVGGDLIVHNLASGARATELKDPNGQLRLLDYSRSSRLLVTAGDDGTVHLWDTTGRSPKSWLKQHSAPTAGVCFSPSNE--------------KIIASVGMDKKLYTYDSGSRRSSSCI-AYEAPFSSLAFGDNGYILVAGTSNGRVVFYDIRGKPTVLHAFSNSEDVTSLSWQTSKPVIVNEKNYTSEMAL... 342
48 -58.300[R] KOG0646 WD40 repeat protein  ali follow..  16  2................................EITVIASSSIDEGIGSWDLKTGTEQLQFKPCASPAHGLTAVGESSQLSARNTSGSIFYWSWTKPQ-AEVKSYPVEPIKALAANNEGTYLVGGGISGDIYLWEVATGKLLKKWHGHYRSVTCLVFSGDDSLLVSGSQDGSIRVWSLIRNTLYEHNFNEHTMSVTDIVIDYGGCVIISSSEDRTCKVWSLSRGKLLKNI-IFPSVINALALDPGGCVFYAGARDSKIYIGAINATQVLGSVSEKGKAITCLAYCADGN---------------LLISGSEDGVVCVWDPKSLRHVRTLIHAKGSRKGPVNNQIVRKTIVANSNKTQVSWKSRGALIPPPLEKYER---PVEDTMDGIVTVDPPPFSDVPVYS.. 373
49 -58.100[S] KOG0310 Conserved WD40 repeat-containing protein  ali follow..  14  2......................................AQPYLPAEKFLS-RKQETILLDEDEPAVVSSVRISPKKPYHVATTSSVRLTLYDTVVCEPLNLFSRFKKGVCSIDFRHDGRLLAIGGDEGKVRIFDVESKVALRVMQASQSTVKSVHFSPRGDTVFSMADDGKIKQYRVADNAVPIIEIQAHEDAIRCGAVSSNDHIVLTGGYDHKVRLWDIRSKEKSLEL-DCEHPVESVLFLPGEQLIATAA-GPIVKIWDTTTGRQLTALQAHYKTVTSLRLATNSTC---------------LLSAGIDRRVNAFRTTNYSLINSW-SMPSPVLDIDVSRDDQTMAIGMGNLLALYRRAEIKKEATASAAIEDKRSLIRTSAPPVKLVEKDRDMQKVDVVAK 359
50 -57.800[S] KOG2106 Uncharacterized conserved protein, contains HELP and WD40 domains  ali follow..  14  157.....VLYNVEEQLQRHYAGHNDDVKCLAVHPDRITIATGQVAGTVRIWDSVTLNTLHVIGFFDRAVTCIAFSNGGTNLCADSNDHVLSVWDWQKEEKLADVKCSNEAVFAADFHPTDTNIIVTCGEITSLLLDTRRKLSYAVQGAHEGGISPLCMLRDGTLVSGGGKDRKLISWSGNYSGDFTPITQGHTDELWGLAIHASKPQFLTCGHDKHATLWDAVGHRPVWD-KIIEDPAQSSGFHPSGSVVAVGTLTGRWFVFDTETKDLVTVHTDGNEQLSVMRYSPDGNHSSFITHLDWSVNSQFLVSNSGDYEILYWVPSACKQVVSVESDGTDINAVCRAHEKKLLSTGDDFGKVHLFSYPCSQPSHIYGGHSSHVTNVDFLCEDSHLISGGKDTSIMQWRV. 716
51 -57.700[S] KOG0321 WD40 repeat-containing protein L2DTL  ali follow..  15  19........TSRANNSLPPTPDSSPAAPSKKHKLYDFLESRGKIETPRKRIKPAQLCKELLIRQLGGSRSHPFSTKTSRHVGGRLNLETYY-----SRPSECLMMLNQLPFCLGFANNESLLAVCTETGALELFDSRSARRIHGWLAHNNAIFSVNFSKDDSLLATSSGDQTSKVFDLSTQQCITRVDGYHSHSVKQVNFCNDSPNLVSCSRDGSIIFWDMRTHGITHENSGRDCSITSATWLPQSTVISSCSANSALKLWDLRTVHTVRTTSKRDFGVTNVCTSPDGER---------------IYAASRDSIIYEYSSRHLNYKDPRLRISSFYVKLACSPDGATLACGGKTSGVVVFDTTRNSSAMLTGGHTKDVTAVDWSSEGQ-LASISDDGSVRVWNSS 466
52 -57.600[I] KOG0301 Phospholipase A2-activating protein (contains WD40 repeats)  ali follow..  14  2....................................ADDGLGDVPMETESMPQYTISHVIEAHKSDTKALAVTQGGC-LISGGRDETVKFWAKKGKQTHAFEQPKGITVNSIAYAEDGWRLFVGRRDGTIAVFGPSQAEPYAIFNEHKQNVCCLHINEKATHMLSGSWDSNVIIWPITESSFTTIVCPGHTLSVWALASFPDLNTYLSASADKTIRMWF--GDTTLSVFKGHTDVVRALVVLSSSH-FLSAGNDGHIIHWDVASASILRKFATQAHEF----------------IYSMTLSDSHILTTGEDGTLEFWAIDGGKSEAVIQLPTTNTWDAKVLLNSD-IAVAGSDGRIYIMTTDKNRKADILDAFDAEVVAKLTAKTERMKQEEHETVTIKVD... 363
53 -57.500[R] KOG2055 WD40 repeat protein  ali follow..  12  168........ALSEKSVIPKSLKSLFKSSVSYINQSSKLLAPGTINIKRLKD------ANFQAPSHSGIRCMSIHPYFPLLLTCGFDRTLRIYQLDVNPLVTSLHLRSSALQTALFHPDGKRVIAAGRRKYMYIWDLESAQVQKVQENFQPSMERFHVDPTGKYIALEGRSGHINLLHA-LTGQFATSFK-IEGVLSDVLFTSDGSEMLVLSYGAEVWHFNVEQRSVVRRWQVQDGSTTHFCLDPSNKYLAIGSKSGIVNIYDLQTSKPVTTLDNITFSINSMSFSQDSQVL-------------AIASRGKKDTLRLVHVPSFSVFRNWATPLGRVTCLAFGKGGE-LCVGNEAGRVGLWKLAHYDLKFVPDKII--NWEIRLGKFGYVLLGIQVDVVI...... 555
54 -57.100[R] KOG1273 WD40 repeat protein  ali follow..  12  2............................................NAPIIDPLQGDFPEVIELEHGVIKCVAFNHRGSLLAAGCADGGCVIWDFETRGIAKEIRDNSAAITSVSWSKYGHRLLVSAADKSLTLWDVSTGEKIARTIPLSSAPMIVDFDIDCTTLLPVSVPEMPDVLAP--PQRSKCPESNPPFSPAAACFNKCGDLVYIGNSKGEILIVDYKSVRVLALVSSGAAPVKNIVFSRNGQYLLTNSHDRTIRIYENLLPAKNKMKTVGSKCLTLFREFQDSVTKMHWKAPCFSGDGEWVVGGSGEHKIYIWD-RAGHLVKILEGPKEALIDLAWHPVHPIIVSVSLAGLVYIWAKDYTENWSAFAPDFKELENEEYVEREDEFDLIPETEKVKVLDVN 390
55 -56.300[R] KOG4227 WD40 repeat protein  ali follow..  14  2............KRRAGLGGSMRSVVGFLSQRGLHGDPLLTQDFQRRRLRGCRNLYKKDLLGHFGCVNAIEFSNNGQWLVSGGDDRRVLLWHMEQAKPIQLKGEHHSNIFCLAFNSGNTKVFSGGNDEQVILHDVESSETLDVF-AHEDAVYGLSVSPVNNIFASSSDDGRVLIWDIRESPHGPFCLANYPSAFHSVMFNPEPRLLATANSKEGVGLWDIRKPQLRYGGNLSLQSAMSVRFNSNGTQLLALRRRLPPVLYDIHSRLPVFQFDFNSCTMKSCCFAGDRD--------------QYILSGSDDFNLYMWRIPANGAFMVLKGHRSIVNQVRFNPHTYMICSSGVEKIIKIWSPKQPGCTGDLDGRIEDDSRCLYTHEEISLVLNSGSGLSHDYANQ 407
56 -56.000[R] KOG1334 WD40 repeat protein  ali follow..  11  215.DEDQALEEWISSETSALPRSRWQVLTALRQRQLGSSARFVYEACGARTFVQRFRLQYLLGSHAGSVSTIHFNQRGTRLASSGDDLRVIVWDWVRQKPVLNFSGHDINVIQAKFFPNDSTLAMCGHDGQVRVAELINASNTKRVAKHRGPAHELALEPDSYKFLTSGEDAVVFTIDLRQDRPVVTRENDKKVGLYTISMNPANIQFAVGGHDQFVRIYDQRRIDKHLVYCDFPTNITCVVYSHDGTELLASYNDEDIYLFNSSLSDGAQYVKRYKGHRNN---------DTIKCVNFYGPRSEFVVSGSDCGHVFFWEKSSSQIIQFMEGRGDIVNCLEPHPYLPVLATSGLDQHVRIWT-PTAKTATELTGLKDVIKKNKQERDEDNLNYTDSFDNRMLRFFV 633
57 -55.800[DO] KOG0305 Anaphase promoting complex, Cdc20, Cdh1, and Ama1 subunits  ali follow..  18  31...........NRSAKDFDFANYALTQGSKRNLDEVTSASRKAYMTQLAVVMNQNRTRILAFRNKPKSLLSTNHSDSPHQNPKPVKPRRYIPQNSERVLAPGLRDDFSLNLLDWGSANVLAIAL--GDTVYLWDASSGSTLVTIDEDKGPVTSINWTQDGLDLAVGLDNSEVQLWDC-VSNRQVRTLRGGHE-SRVGSLAWDNHILTTGGMDGKIVNNDVRIRSIVETYLGHTEEVCGLKWSESGNKQASGGNDNVVHIWDRSLAQWLHRFEEHTAAVRALAWCPFQASLLAT------------GGGVGDGKIKFWNTHTGACLNSVETGSQ-VCSLLWSQSERELLSSHTQNQLTLWKYPSMSKMAELNGHTSRVLFMAQSPNGCTVASAAGDENLRLWNVF 418
58 -55.100[U] KOG1332 Vesicle coat complex COPII, subunit SEC13  ali follow..  22  7...................................................................................................TVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGLIADLRGHEGPVWQVAWAHPGNILASCSYDRKVIIWREENTWEKSHEHAGHDSSVNSVCWAPHGLILACGSSDGAISLLTYTGEEVKKINNAHTIGCNAVSWAPAVKRFASGGCDNLIKLWKEEEDGEEQKLEAHSDWVRDVAWAPSI-----------GLPTSTIASCSQDGRVFIWTCDDASSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKESVDVCISDVNKGQGSVSSVTEGQQNEQ................ 322
59 -54.500[DK] KOG0973 Histone transcription regulator HIRA, WD repeat superfamily  ali follow..  17  2..........................................................TFVGHDGSILAIDCHPSGKKFITCTSNGLVVVWNAENVPKLLFQVESQSQSNSCRWSPDGKRFAFGSDDSSVSVWNVERYKECCVLRGHSMEVLTVEWSPNGKYLASGSIDYRIIIYNARKLPDRITVLNDIQLPVKGLSWDPIGKYLASLEGDKKLRFWATDSWQCVKSVTIEETMLTRLDWSPDGKYLMTPAAVRLIKLIQRQTWKSDQFLAGHHKGTTCVRAMP--RLIEANLKNGKRMQLTCAAVGSRDKSISIWVFPGTLKPLFVINNIFNHTVMDFAWCGRNLLACSQDGTVKVIHLSESVIGEMIEAMSDLCYQIYSIRPPRYELTDKEEDESQ..... 386
60 -54.400[BL] KOG1009 Chromatin assembly complex 1 subunit B/CAC2 (contains WD40 repeats)  ali follow..  16  4......................................................ITCEIAWHNKEPVYSLDFQHGTARLASAGVDTNVRIWKVEKGEFLSNLARHTKAVNVVRFSPTGEILASGGDDAVILLWNKENWTVVKTLRGHLEDVYDICWATDGNLMASASVDNTAIIWDV-SKGQKISIFNEHKSYVQGVTWDPLGQYVATLSCDRVLRVYSIQKKRVAFNVSSMKSFFRRLSFTPDGSLLLTPAGCVESGENVMNTKRPIAHLPCPGKATLAVRCCPVYPVVETGVELMSLPYRLVFAVASEDSVLLYDTQQSFPFGYVSNIHYHTLSDISWSSDGAFLAISSTDGYCSFVTFEKDELGIPLKEKP--VLNMRTPDTAKKTKSQTHRGSSPGPR.. 414
61 -54.200[Z] KOG0313 Microtubule binding protein YTM1 (contains WD40 repeats)  ali follow..  22  10........................TDNKKYAVDDVPFSIPAASEIADL----SNIINKLLKDKNEFHKHVEFLIKGQFLRMPLDKHEIEYVEKCTAPQPEQCMFHDDWISSIKGAEEW--ILTGSYDKTSRIWSL-EGKSIMTIVGHTDVVKDVAWVKKDSLLLSASMDQTILLWEWRNKVKALHCCRGHAGSVDSIAVDGSGTKFCSGSWDKMLKIWSTVPTDPIVTLSGHMEAVSSVLWSDAEE-ICSASWDHTIRVWDVGSGSLKSTL-TGNKVFNCISYSPLCK---------------RLASGSTDRHIRLWDPRTKDVSLSLTSHTGWVTSVKWSPTHQQLISGSLDNIVKLWDTRSCKPLYDLAAHEDKVLSVDWTDTGL-LLSGGADNKLYSYRYS 415
62 -54.200[S] KOG4328 WD40 protein  ali follow..  12  117........GSYTQLVDTLLGIESKSCRGKLVKGEIGVVKDENESPMVRTRSSSRVSKVSVKKEEPEDDSFSDYVNKEFSIPVKPEKIEFDLDLLTLEPQNVARVVPGRIFVVQFLPNVKMVAAGDKLGNVGFWNLDCGDGIYLFTPHSAPVSSIVFQQNSSRVISSSYDGLIRLMDVEK--SVFDLVYSTDEAIFSLSQRPNDQSLYFGQDYGVFNVWDLRAGKSVFHWELHERRINSIDFNPQNPVMATSSTDGTACLWDLRSKPKTLSTVNHSRAVHSAYFSPSGLS---------------LATTSLDNYIGVLSGANFENTCMIYHNNTSKFKAVWGWDDSYIYVGNLSKKIDVINPKLKRTVMELHNPRAIPCRIHCHPNVGTLAGSTAGGQVYVWTTK 516
63 -54.000[YU] KOG2445 Nuclear pore complex component (sc Seh1)  ali follow..  15  2..................................................................................................QPFDSGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDELSDSWRAHDSSIVAIDWASPGRIIASASYDKTVKLWEEDPDWNKLCTLNDSKGSLYSVKFAPAGLKLACLGNDGILRLYDALEPSDLRSPANHLQSDFCLSWCPSRFEKLAVSALEQAIIYKDGKLHVAAKLPGHKSLIRSISWAPSI-----------GRWYQLIATGCKDGRIRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTELQSNLQVELLSEHDDHNGEVWSVSWNLTGTILSSAGDDGKVRLWKAT 334
64 -53.600[R] KOG2321 WD40 repeat protein  ali follow..  2.............SLKVQNPNNVRVYTVSGEGVTQRLPNWISKRKLK-KDYALSHRIELLQEYPEASNRIKCTRDGKYAMATGVKPHIKVFDFAEMSLKFERHTDAENVQFEILSDDWTKSVHLQTDRTVDFHSQGGIHYSTRIPKY---GRDLKYHYPNCDLYLAAAGDEVYRLNLEQGKIESAQIDSPTGGVNVIDINPMHQLLAFGTDAGSVEFWDPRDRSRVGILEDNSRSVTALKYRNDGLNVAIGLSDGATLLYDLRSSSPYMSDQGYSMPIKSLHWMDSA------------LDGTARVLSADSKIIKIWEKDTGKPFSSI-EPTVELNDVCPIEGTGLILTANEGSPMHAFYIPSNPAPRWCSFLDNITEEMEENPDDYKFVTKKELLNLGLDHL. 401
65 -53.600[R] KOG1310 WD40 repeat protein  ali follow..  17  1........................................................MDNLSFHDGNIFNLLHTRSQDPSHEVDQRMQFHSSLVRRLSQEQELEGHQGCVNALAWNSNGSLLISGSDDLRINIWNYSSRKLLHSITGHTANIFCTKFVPEDELVVSGAGDAEVRLFNTSRLSIPSALYQCHTRRVKKLAVEPGNNVVWSASEDGTLRQHDFRESTALADPPKQTLSLKSCDISARPHLLLVGGSDAFARLYDRRM-MHLSERGRTNLHLTHVTFSPNGEEVDKPMENTVDNASSGTASSSQNDRTSYQPEGAIDMKRRYVGHCNVGTDIKLGQRGEYIASGSDDGRWFIWEKQTGRLMKVLVGDESVLNCIQCHPFDSVVATSGIDNTIKIWS.. 688
66 -53.300[A] KOG0647 mRNA export protein (contains WD40 repeats)  ali follow..  15  2.....................................................................SFFNRSNTTSALGTSTAMANEKDLAND--IVINSPAEDSISDIAFSPQQDFMFSASSDGKVRIWDVQNGVPQRAQHESSSPVLCTRWSNDGTKVASGGCDNALKLYDIASGQ--TQQIGMHSAPIKVLRFPSNTECIVTGSWDKTIKYWDMRQPQPVSTVMMPER-VYSMDNKQSLLVVATAERHIAIINLANPTTIFKATTSPLKWQTRCVACYNEADG---------------YAIGSVEGRCSIRYIDDGMPGSNGQSLVYPVNSIAFHPLYGTFVTAGGDGTFNFWDKNQRHRLKGYPTLQASIPVCSFNRNGSVFAYALSYDWHQGHMGN 341
67 -53.100[R] KOG4497 Uncharacterized conserved protein WDR8, contains WD repeats  ali follow..  13  1..............MNFSEVFKLSSLLCKFSPDGKYLASCVQYR-LVVRDVNTLQILQLY-TCLDQIQHIEWSADSLFILCAMKRGLVQVWSLEQPEWHCKIDEGSAGLVASCWSPDGRHILNTTEHLRITVWSLCTKS-VSYIKYPKACLQGITFTRDGRYMALAERRDCVSIFVC-SDWQLLRHFDTDTQDLTGIEWAPNGCVLAVWDTCLEYKILLYSDGRLLSTYSAWSLGIKSVAWSPSSQFLAVGSYDGKVRILNHVTWKMITEFKSPQLGLGCLSFPPPRAGAGPIGMLAFSPDSYFLATRNDNNAVWVWDIQKLR-LFAVLEQLSPVRAFQWDPQQPRLAICTGGSRLYLWSPAGCMSVQVPGEGDFAVLSLCWHLSGDSMALLSKDHFCLCFLET 445
68 -53.100[R] KOG2919 Guanine nucleotide-binding protein  ali follow..  11  79........EDTLELTSNGNEAKPEDQELAIAPVLQYFQGALVELGRRCWTSS--------TEAQHYTKGCYWSPDGTCLLVPVHLDGMHVIEMPSDLYSADTVQEGGTVYDCVWYPHMNLWLATRQHEPIHMWDAFDGSLRCSYSGYDMAAISLAFSHDGEQIYA-GYKRCIKIFDTSRPGR-FCDDYPVKFAISCIAQTTAHPTLTCGNWHGYIQHFDLRCSHPLFTLGGHKGGITQLRYGEFGNLFSGARKCDKILQWDMRYKQPLVELQRHVDTNQRIQFD-------------LASDSNWLASGDTRGFVNVWDLKKYGDPSVLPLHSDCCNGVALNPAMPILATSSGQ---FHFTDQSAQGDNVTLNGTETTELPAPADVNQNQKEVLYENAVVMWWC. 483
69 -52.700[R] COG2319 FOG: WD40 repeat  ali follow..  13  89IPMTSNKDTISLGRHSSLSRNLVNKTKNASETYQQLLEYAEVERDDNVFTYAKLQKSDM----TQKCPTMVASEKDNKGKLNEKKNRSPENLLPFRILDAPELRDDFYTSLLSWSPKGDLAIGL--AENIYLWSKELGP-TRVLEESIYDVSSVAYSYNGDILAVGRVDGTLQFWQDNER--VPRISIHHPGDIGVLAWKPETNRLLVGKGNGNIFVYDIIAVLVATITNAHDEQVCGLTWNHDGSQFASGGNDNRVCLFKGSDLRQPLYVWQQNAAVKALSFCPWQRSLLATG------------AGSHDKHIRFYNCFNGKKIDELYCGAQ-ITSIHWSPKYREFSVTTVQHRFAVYSWPQLECLVSVLVPDIRCVHSVLTSQTDSIIIASSNETIKFFDL. 497
70 -51.900[U] KOG0771 Prolactin regulatory element-binding protein/Protein transport protein SEC12p  ali follow..  11  2........ASNQQPPSNLQTYGVPIYAVDWILEEAVRSKITKDQDDDDDDGSSSSSYIVLSGGGG--EGRSGIPNVILICRVDLHTNS------SEQPIGRRVIGTDLPYRMAIHPRQGGLICALPENIIEDDNEEESEKVVKELKDVGQQLSLSFNQDGTVLATGAEDGTLRVFEWP-SMKTLLNESKTHASVKSLTFSESGKFLVSLG-APLCRVWDVNASAAIASLSKEKDEFASCRFSVDNSVAANTQRGGSIITWDTTSWRRRSSLIKRNNSISAFNVSADGK---------------LLAVGTLEGDVLIIDSTKMQTNQIVKAHLGLVTALTFSPDSRCLVSVSFDSRARLTVIKQKGEKRVYLWVAALLFVLVYVVLYYLMVAMGIIH........ 383
71 -51.700[T] KOG1354 Serine/threonine protein phosphatase 2A, regulatory subunit  ali follow..  12  1.....................................MAGAGGGNDIQWCSQVKGAVDDDVAEADIISTVEFNHSGELLATGDKGGRVVIFQQEQENKIQSHSEYNVYSTFQSHEPEFDYLKSLEIEEKINKIRVEASPRRIFANAHTYHINSISINSDYETYLSAD-DLRINLWHLEITDRSFANMEELTEVITAAEFHPNSNTFVYSSSKGTIRLCDMRASALCSFFSEIISSISDVKFSHSGRYMMTRD-YLSVKIWDLMENRPVETYQVHEYLRSKLCSLYENDCIFDKFECCWNGSDSVVMTGSYNNFFRMFDRNTKRDITLEASRENNKPRTVLKPRKVCASGKRKKDEISVDSL----------DFNKKILHTAWHPKENIIAVATTNN-LYIFQDK 445
72 -51.600[S] KOG0294 WD40 repeat-containing protein  ali follow..  16  2.........................................................................PPEMEIIEATNEELLLGFKLIKSELKQTFADSSYARSITSLAVQWPWVASGGTDGRIFVYDMRTRKQSQIILSHAGRVNTLKFTPDLSLLLSGSDDGHMIATRVGSWTKEYDWQKAHAGAVTHVSCHPSSKLALSLGGDQVLNTWNLVNGCVAHKTNTLDFQTGCLSWSKQGDHFTLSG-PLVLEIWGIENAHVMRRIE-MPSKPICITWLDGN----------------ECLTGLDNGNIAWISLKDEDPPTFILAHEVRVKAIAY--LNEFLATVSIAGQIKVWKIDMETRKLEEIARSFMPTDLGLLDLRQFGNVRPVEQRTKVEEKP 334
73 -51.600[D] KOG1036 Mitotic spindle checkpoint protein BUB3, WD repeat superfamily  ali follow..  14  1.........................................................................................MTTVTPSAGRELSNPPSDGISNLRFSNNSDHLLVSSWDKRVRLYDVSTNSLKGEF-LHGGAVLDCCFHDDFSGFSVGA-DYKVRRIVFNVGKE--DILGTHDKAVRCVLFCDVTGQVITGSWDKTVKCWDPRGASGPERTQTYLQPERVYSMSLVGHRLVVATAGRHVNIYDLRNMSEQRRESSLKYQTRCVRCYPNGTG---------------YALSSVEGRVAMEFFDLSEKSEAGRDIVYPVNSIAFHPIYGTFATGGCDGFVNIWDGNNKKRLYQYSKYPTSISALSFSRDGQLLAVASSYTAIFVRSVN 338
74 -50.400[R] KOG0322 G-protein beta subunit-like protein GNB1L, contains WD repeats  ali follow..  11  3............................................................................................VLPPDPVFSLRSPDGAVNSLCFQESDR-LLAGTIKGSVFLWDLQTNRSALHFEVGSDPITSLHHTPDR--LVTQEKGGTITMFSIGGSSYVGNHLGFCRSALHTNTSKTNEQLLFYPCEESSIGVLHVTDAAAPTQILVPDDTCFKPFECASQLFLLAGYESGHFLTWDISSSVIL-DVMELAQDATSVDYDPVTNR---------------GIVGGPTDKLISFSYQRSQLGSELCIKNPGVNGVRIRPDQKVFASAGWDGRIRIFSWKSLRPLAVLTQHKNGVMDLAFSSQAPIMAAAGMDGQISLWDL. 321
75 -50.000[T] COG5170 Serine/threonine protein phosphatase 2A, regulatory subunit  ali follow..  2....................................DDIEDSLDQWKFAQCFGDKGDVEDITEADIISAVEFDHTGDYLATGDKGGRVVLFERNHSKKGCEYKEIEEKINKIRWCKRTNHFLLSTNDKTIKLWKLYEKNLKVVAENNLSDSFHSPMQGPLTTPSQLRLPRLNHHDMIIAAYPRRVYANAHAYHINSISVNSDAETYISAD-DLRINLWNLSISDHSENMEELTEVITSAEFHPNCNHLMYSSSKGNIKLLDLRQSALKSFFSEIISSISDVKFSQNGRY----------------ILSRDYLTLKIWDVNMKAPVKTIPLHDV-KFECTFSGDDKHVLSGSYSNNFGIYPTDSSLPGDDNLDYNKKILHASWHPFEDSVAIAATNN-LFVFS.. 461

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Zhao Y, Hong DH, Pawlyk B, Yue G, Adamian M, Grynberg M, Godzik A., Li T. The retinitis pigmentosa GTPase regulator (RPGR)- interacting protein: subserving RPGR function and participating in disk morphogenesis. Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):3965-70. Epub 2003 Mar 21.