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Query: [J] KOG0650 WD40 repeat nucleolar protein Bop1, involved in ribosome biogenesis, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MTKKLALKRRGKDSEPTNEVVASSEASENEEEEEDLLQAVKDPGEDSTDDEGIDQEYHSDSSEELQFESDEEGNYLGRKQSSSAEEDEESSDEEDNEEEESTDGEEVEDEEKDSKSKQTDDKPSGSGAASKKALTAELPKRDSSKPEYQDSDTSDEEDIRNTVGNIPMHWYDEYKHIGYDWDAKKIIKPPQGDQIDEFLRKIEDPDFWRTVKDPLTGQDVRLTDEDIALIKRIVSGRIPNKDHEEYEPWIEWFTSEVEKMPIKNVPDHKRSFLPSVSEKKRVSRMVHALKMGWMKTTEEVEREKQAKRGPKFYMLWETDTSREHMRRIHDPVSAPKRDLPGHAESYNPPPEYLFDAKETKEWLKLKDEPHKRKLHFMPQKFKSLREVPAYSRYLRERFLRCLDLYLCPRAKRVKLNIDAEYLIPKLPSPRDLQPFPTVESMVYRGHTDLVRSVSVEPKGEYLVSGSDDKTVKIWEIATGRCIRTIETDEVVRCVAWCPNPKLSIIAVATGNRLLLVNPKVGDKVLVKKTDDLLAEAPSQDVIESERIKTAVQWSNAEADEQEKGVRVVITHFKPIRQVTWHGRGDYLATVMPEGANRSALIHQLSKRRSQIPFSKSKGLIQFVLFHPVKPCFFVATQHNIRIYDLVKQELVKKLLTNSKWISGMSIHPKGDNLLVSTYDKKMLWFDLDLSTKPYQTMRLHRNAVRSVAFHLRYPLFASGSDDQAVIVSHGMVYNDLLQNPLIVPLKKLQTHEKRDEFGVLDVNWHPVQPWVFSTGADSTIRLYTLast
1 -198.000[J] KOG0650 WD40 repeat nucleolar protein Bop1, involved in ribosome biogenesis  ali  100  1MTKKLALKRRGKDSEPTNEVVASSEASENEEEEEDLLQAVKDPGEDSTDDEGIDQEYHSDSSEELQFESDEEGNYLGRKQSSSAEEDEESSDEEDNEEEESTDGEEVEDEEKDSKSKQTDDKPSGSGAASKKALTAELPKRDSSKPEYQDSDTSDEEDIRNTVGNIPMHWYDEYKHIGYDWDAKKIIKPPQGDQIDEFLRKIEDPDFWRTVKDPLTGQDVRLTDEDIALIKRIVSGRIPNKDHEEYEPWIEWFTSEVEKMPIKNVPDHKRSFLPSVSEKKRVSRMVHALKMGWMKTTEEVEREKQAKRGPKFYMLWETDTSREHMRRIHDPVSAPKRDLPGHAESYNPPPEYLFDAKETKEWLKLKDEPHKRKLHFMPQKFKSLREVPAYSRYLRERFLRCLDLYLCPRAKRVKLNIDAEYLIPKLPSPRDLQPFPTVESMVYRGHTDLVRSVSVEPKGEYLVSGSDDKTVKIWEIATGRCIRTIETDEVVRCVAWCPNPKLSIIAVATGNRLLLVNPKVGDKVLVKKTDDLLAEAPSQDVIESERIKTAVQWSNAEADEQEKGVRVVITHFKPIRQVTWHGRGDYLATVMPEGANRSALIHQLSKRRSQIPFSKSKGLIQFVLFHPVKPCFFVATQHNIRIYDLVKQELVKKLLTNSKWISGMSIHPKGDNLLVSTYDKKMLWFDLDLSTKPYQTMRLHRNAVRSVAFHLRYPLFASGSDDQAVIVSHGMVYNDLLQNPLIVPLKKLQTHEKRDEFGVLDVNWHPVQPWVFSTGADSTIRLYT 784
2 -72.000[D] KOG0642 Cell-cycle nuclear protein, contains WD-40 repeats  ali follow..  12  2.............DEQAGPGVFFSNNHPGAGGAKGLGPLAEAAAAGDGAAAAGAARAQYSLPGILHFLQHEWARFEVERAQWEVERAELQQGERKGQENLKKDLVRRIKMLEYALKQERAKYHKLKYGTELNQGDMKPPSYDSDEGNETEVQPQQNSQLMWKQGRQLLRQY--LQEVGY----TDTILDVKSKRVRALLGFSIDVTDRED--DKNQDSVVNGTEAEVKETAMIAKSELDSASVLDNFKFLESAAADFSDEDEDDDVDGREKSVIDTSTIVRKKALPDSGEDRDTKEALKEFDFLVTSEEGDNESRSAGDGTDWEKEDQCLMPEAWNVDQGVITKL-GKKGVKRPNRSKLQDMLANLRDVDELPSLQPSVGSPSRPSSSRLPEHEINRADEVEALTFPPSSGKSFIMGADEALESELANNKDALRKTWNPKFTLRSHFDGIRALAFHPIEPVLITASEDHTLKMWNLQKTAPAKKSAHKGPVLCVVMSSNGE-QCYSGGTDGLIQGWNTTNPNIDPYDSYDP------------------------------SVLRGPLLGHTDAVWGLAYSAAHQRLLSCSADGTLR---LWNTTEVAPALSVKELGIPASVDLVSSDPSHMVASSKGYTSIFNMETQQRILTLENSSCQINRVISHPTLSISITAHEDRHIKFYDNN-TGKLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRLWNLESKT---------CIQEFTAHRKKFEESIHDVAFHPSKCYIASAGADALAKVFV 780
3 -67.400[A] KOG0291 WD40-repeat-containing subunit of the 18S rRNA processing complex  ali follow..  8...............................................................................................................................................................SNLLGTI-----YRNGNLVFTPDGNSVISPV-GNRI--------------TVYDLKNNKSRTLSLESRYNYTNIAGSLLIAVNEKGEAQLISMMSCTVIHRHKFQTGVQCICFSPNVAVQNVVLIFCAPGEITGEYNPFVLRRRFLGGFDDVTWLDWSSDSRLLAIGCRDSSTKIVAINYTKNFRTYN-----LSGHTDAIVACFFEANSLHLNTISRNGQLCLWECSLAPSDLEDAERPKIAPPQRKKEKKAVSDNESEDDVENVVEKDALKEESTKADEPRKEQRDVQLTAANYNTRTKVLVVAFSSGAFYLYELPDVNMIHSLSSDYPISAALFNCTGDWVALASREIGQLLVWEWQSEQIMKQQGHSSEMTCIAYSSDGQFIATGGEDSKVKLWNTQSSFCFVTFSEHTSGVTGIQFSRNKKFLVSSSLDGTVR---AFDVNRYRNFRTFSPNPAQFSCVAVDYSGELVVAGGQDDIFLWSVKTGKLLEIISGHEGPVVSIAFSPTSSTLVSGSWDKTVKIWNCL-ESNSEHETIDAVSDVTNVTFSPSGEEIAVATLSGNITIFDIKSAGQ---------VTTIEGRNNAQANYFSTIEYSADGECILAAGKSANICIYH 655
4 -67.200[S] KOG0271 Notchless-like WD40 repeat-containing protein  ali follow..  12  2.................................................................................................................................................................................................................................................................................................................TESPQISVSFVSEDENELGGSGILVPVDI------STNELQILCNQLLGSSDDPVPISFFTTEGAEIVDSIRKSLEERVRPVTRCSASIPGHGEPVISAQFSPDGRGLASGSGDQTMRIWDIELEL-------PLHTCKSHKSWVLCIAWSPDATKIASACKNGEICIWNAKTGEQIGKTRHKQWITSLAWQPTCRLLASCGKDGNIFIWDTVQGTVVRCLSGHTASVTCLRWGGEGL-IYSGSQDRTVKMWRADDGVMCRNMTGHAHWINTLALNTDYALRTSCFEPSKRC---IKPDTVEECQKVAQTR---YEAALEIAGGERLVSGSDFTLFMWNPKTKQSINRMTGHMQLVNQVVFSPDTRYIASASFDKSVKLWCGR-TGKYLASLRGHVGPVYQVAWSADSRLLVSGSADSTLKVFELKTKS---------LYYDLPGHG----DEVFTVDWSPEGTKVVSGGKDKVLKLWR 472
5 -66.000[BK] KOG1063 RNA polymerase II elongator complex, subunit ELP2, WD repeat superfamily  ali follow..  10  150..................................................................................................................................................DVSFPSQPSEECKVVCLDSICVD---SLAELPQNPGRFALALGGLDNKIK--LYSGERTGKFTSV--------CELKGHT-DWIRSLDFSLPLHTTEEIPNSIMLVSSSQDKVIRIWKLVLVGDVGSWRREITLASYIEGPVFVSGTFTYQISVESVLIGHEDWVYSVEWQPPVIDFLSASMDKTMMIWRPEKKTGVWVNVVCVGELSHCALGFYGGHWSPNSLSILAHGYGGAFHLWRNVSQMQKVPSGHFAAVTDVTWARTGEYLLSVSQDQTTRVFSAWKND-EHWHELARPQVHGHDINCVAMVQGKGNHRFVSGAEEKVVRVFEAPLSFLKTLEGSFPEDLQADVQVLGAN--MSALGLSQKPIYLHSSSEPLERNGGGEGLDTFETVPEAAPAELKEPPIEDQLAFHTLWPESHKLYGHGNELFSLCSDHKGNLVASSCKAQSASMIWLWEVGTWKAVGRLQSHSLTVTHLEFSYDDTLLLSVSDRHFSVFSIQRTKLMAKVEAHKRIIWACSWNPFGHQFATSSRDKTVKIWSVENDARQILVLPPFGSSVTAVAWTGLDRCVAVGMESGLIELSNVKIIETTATAALALRLEPFMCHVSA----VNRLAWRPTEKWLTSCGDDNCVRVFN 837
6 -65.700[K] KOG0263 Transcription initiation factor TFIID, subunit TAF5 (also component of histone acetyltransferase SAGA)  ali follow..  11  2.......................................................................................................SATNGPQPQDLNRIVLDYLAKKGYSRTEAMLRLEASGSGVSVEEKLKSIEETPDAYTHTYTIL-RDWVDSSLEL-YKAELHRILFPI----VHSYLNSQDHYEAAKQFYELFKDDHTDLHDFDVKNLKSLSLPSHVAED-----RTAQQYRQNKYQLHFSRITFDLLLHFLFENVSNGGSIIIKLINQHIDIHIVPGRPTVLENAKVINEQEGITGQSFERGDAQLQPVKL------QQMPMDKEMEKIVEMDLEEEDMMHQNDPNNQSPKLLKEFRKLHEPNAEDAPSRDYIPLPPHKGVDILSEVEAVKDWSKRLHL-------GPRASLPSVCMYTFHHTNNNMNCAEFSPDSTMIACGFQESYIRLWSIKADKKSRLLSHSGPVYGTTFSPDNKYLLSCSEDAS------------------------------------------ARLWSVDTKTALVAYKGHTGPVWDVAFGPFGHYFATASHDQTAQ---LWSCDHIYPLRVFAGHLSDVDCVTFHPNSAYVLTGSDKTCRLWDVHRGHSVRVFNGHTQPVTAVAIAPDGHTMASADSEGLIHLWDIG-TGRRIKTMRGHRGNIYSLSFSRESTVLVSGGSDCTVRAWDVFKTNEVNWSTSPDQMVALYTKQ----TPIFNVSFTRRNLCLAISVS........ 643
7 -65.200[R] KOG0286 G-protein beta subunit  ali follow..  15  1...............................................................................................................................................................................................................................................................................................................................................................................................MGEMEQLRQEAEQLKKQIADARKACADVTLAEL--VSGLEVVGRV-------QMRTRRTLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAILRSSWVMTCAYAPSGN-FVACGGLDNMCSIYNLKSRE-------------------------------------GNVKVSRELSAHTGYLSCCRFLDDNNIVTSSGDT----TCALWDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGADASAKLWDVREGTCRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFDLR-ADQELICFSHESCGITSVAFSLSGRLLFAGYDDFNCNVWDSMKSE---------RVGILSGHD----NRVSCLGVTADGMAVATGSWDSFLKIWN 340
8 -64.800[S] KOG0295 WD40 repeat-containing protein  ali follow..  15  9......................................................................................................................................................................................................................................................................................................................................................EEINRAIAEYMQNNGYSESFSVFLKESSLSENDIKPLGGILEKKWTTVLRLQRKVNDLESKLQESQREINHGAPTRDKRQAADWIPRPP-------ETQKLTGHRLPITRVIFHPLWTIMASCSEDATIKVWDYETGQLERTLGHTDAVNDIAIDAAGKQ-LVSCSSDLSIKLWDFG----------------------------------------QTYDCLKSLKGHEHTVSSVTFLPTGDFVLSASRDHTIK---QWDISTGYCVYTFRGHNDWVRMIRISNDGTLFASASDQTVTVWSFATKSAKLVLRDHEHAVECVEWAPDTAYLFSGSRDRSIKAWNIN-TGDVLFTLLAHENWVRGLAFHPKGKYLISVADDKTLRVWELSAQR---------CMKAIEAHEHF----VSTVAFHQTSPFVITGSVDMSCKVWE 402
9 -64.500[B] KOG0273 Beta-transducin family (WD-40 repeat) protein  ali follow..  12  1...........................................................................................................................................................................................................................MSITSDEVNFLRYLQESGFSHSAFESHISQSNINGTLVPPSALISILQKGLQYVEAEISINKDGTVFDSRPIESLSLIVAVIPDVVQMRQQAFGEKLTQQQASAAATEASAMAKAATMT--PAAISQQNPPKNREATVNGEENGAHEINNHSKPMEIDGD----VEIPPNKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSVLRHCIREGGHDVPSNKDVTSLDWNSDGTLLAMGSYDGFARIWTENGNLASTLGQHKGPIFALKWNKKGNYVLSAGVDKT------------------------------------------TIIWDAHTGEAKQQFPFHSAPALDVDWQNNMT-FASCSTDMCIH---VCRLGCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPMLASASFDSTVRLWDVE-QGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNTQSGS---------LVHSYQGT-----GGIFEVCWNARGDKVGASASDGSVCVLD 521
10 -64.100[A] KOG0265 U5 snRNP-specific protein-like factor and related proteins  ali follow..  18  5................................................................................................................................................................................................................................................................................................................................................................................................RPNNSVILAQEAKRSKNDLMAYTNRDKALLESGVRRTSNLQAP------------IMQLEGHEGEIFTAEFHPEGELLLSSGFDRQIYIWQVYEDCENAMSGHSGAVMEAHFTPDGSHIFTCSTDKT------------------------------------------LAFWDIATGQRQRRFKGHGNFVNSVQGSRRGQQLLCSGSDD--RTIKIWDARKKHAAHTLESPFQ-VTAVCFGDTGEQVISGGDNEVKIWDIRKQAVLHHLRGHSDTITGMSLSPEGDFILTNAMDNTLRVWDVRPGERCVKVFQGHQHNLLRCAWSPGSDKITSGSADRHVYIWDVNTRR---------ILYKLPGHN----GSVNAVDFSPKEPLILSGSSDKTLYLGE 344
11 -63.800[A] KOG0319 WD40-repeat-containing subunit of the 18S rRNA processing complex  ali follow..  23................................................................................................................................................................................VRWSANGQKLFSTCTNV----------------KVIDLADNTASYTDPEDELRITCTA------------------VDKNRNRLLVAYNNQIIREYSIPLDPSTTKPELARTWKTI--------------HTAPILVMEFNEEGHLLATGSADHIVKVWNLTEQQCTHTLK---------PSVVSAILFGKHEKLVVGYIEGQLNLY-GAPKKLVNTWKSHNSHITALLQVPDSRVVVALSRDQTMSIHETETQETVIETAKLVRKKRIASSNLDHLAYDVVSNRFLAISAEQNLIILDFENLKIARQIFHDEIYSCCLLGKDESHMAVASNTSEIRLYNTKTLDCQLIRGHTESVLSVVSPTWDTSLLASCSKDNSIIFWRCSTLVPVAAATGHANTVTALAISNTGRFLASVSTDCTIKLWFVEQLPKLTCSSTMVAHGKDVNCVDISESDALIATGGDKLVKLWQVDTHKIAGTLSGHRRGVGDVKFAKNSHKLASCSGDMTIKIWNIS-EKSCLQTISGHSCAVFRVIFARNDSQLISADSAGIIKIWTIKTAD----------ECSIDAHTDK----IWSLSKNHNESEFVTAGTDGRIVVWK 635
12 -63.300[R] KOG0645 WD40 repeat protein  ali follow..  14  1...........................................................................................................................................................................................................................................................................................................................................................................................................................................................SGHTGRLWSVAAHPMLPLFATSSQDKSVRIYNSNTYNLVHVIFHTRSIRRVAWRPIERPVLAVASFDSVVSINEKIDD---------------------------------------DWECTAALEGHENEVKCIAWSCNGNYLATCSRDKSVWIWEATEDDEFDCLAVLQEHTQDVKVVTWHPTEDLLVSGSDNSICFWRDDDWALTCQLQGHTNTVWALAFSPNGNTLASADNDGNVFLWIKISSNQQTSLPHIHKGAVYTISWMNDA-TLCSAGGDGKIVVYQREKHDEALW--HVAYEQDHAHGVYE----INSLEYLRDDR-LLSGGDDGECRVWS 320
13 -63.000[A] KOG0306 WD40-repeat-containing subunit of the 18S rRNA processing complex  ali follow..  29................................................................................................................................................................................VTLRGEKGRYVAVPACEHV--------------FIWDLRKGEKILILQGLKQEVTCLC--------------------------------SPDGLHLAVGYEDGSIR---------FSLLSGEGNVTFNGHKAAITTLKYDQLGGRLASGSKDTDIIV------WDVINESGLYRLKGHKDAITQALFLREKNLLVTSGKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRLITGASDSELRVWDIAYLQEIEDPRKAGSIMREGRDRVVNLAVDKTGRILACHGTDSVLELFCILSKKEIQKKGHRSDVRTLSFSSDNI--AVLSAAADSIKIWNRSTL-QCIRTMTCEYALCSFFVPGDRQVVIGTKTGKLQLYDLASGNLLETIDAHDGALWSMSLSPDQRGFVTGGADKSVKFWDF-QKRLSVKQTRTLQLDEDVLCVSYSPNQKLLAVSLDCTVKIFYVDTLKFFLSLYGHKLPVICMDISHDGALIATGSADRNVKIWGLD-FGDCHKSLFAHDDSVMYLQFVPKSHLFFTAGKDHKIKQWDADKFE----------IQTLEGHH----QEIWCLAVSPSGDYVVSSSHDKSLRLWE 703
14 -62.900[A] KOG0285 Pleiotropic regulator 1  ali follow..  13  1................................................................................................................................................................................................................................................................................................MIALNREVETQSLKKLSLKSVRRAREIFSPVHGQFPQPDPESKRIRLCHKIQASKPTRIADHNSEKTAPLKALALPGPKGSKELRKSATEKALVVGPTLPPRDLNNTGNPGKSTAILPAPGSFLSTAALMERMPSRWPRPE----HAPWKNYRVLQGHLGWVRSVAFDPSNEWFCTGSADRTIKIWDVATGVLKLTLGHIGQVRGLAVSNRHTYMFSAGDDKQ------------------------------------------VKCWDLEQNKVIRSYHGHLHGVYCLALHPTLDVVLTGGRDSVCR---VWDIRTKMQIFVL-PHDSDVFSVLARPTDPQVITGSDSTIKFWDLRYGKSMATITNHKKTVRAMALHPKENDFVSASADNIKKFSLPK-GEFCHNMLSLQRDIINAVAVNEDG-VMVTGGDKGGLWFWDWKSGHNFQRAE-TIVQPGSLESE----AGIYAACYDQTGSRLVTCEGDKTIKMWK 454
15 -61.200[U] KOG0276 Vesicle coat complex COPI, beta` subunit  ali follow..  13  1...............................................................................................................................................................................................................................................................................................................................................................................................MPLRLEIKRKLAQRSERVKSVDLHPTEPWILASLYSGTLCIWNYQTQVM-------AKSFEVTELPVRSAKFVARKQWVVAGADDMYIRVYNYNTMDKVKVFAHSDYIRCVAVHPTLPY-VLSSSDDMLIKLWDWEKGWAQIFEGHSHYVMQVTFNPKTNTFASASLDRTIKIWNLGSPDPNFTLDAHQKGVNCVDYFTGGDYLITGSDDHTAK---VWDYQTKSCVQTLEGHTHNVSAVCFHPELPIIITGSDGTVRIWHATTYRLENTLNYGLERVWAIGYIKSSRRVVIGYDEGTIMVKL--GREIPVASMDNTGKIIWAKHNEIQTANIKSIGADYEVTDGERLPLS----------VKELGTCDLY----PQSLKHNPNGRFVVVCGDGEYIIYTA 381
16 -60.800[Z] KOG0318 WD40 repeat stress protein/actin interacting protein  ali follow..  13  3.........................................................................................................................................................................................................................................................................................................................................................................................QPQPPAYENKNIYATLPRTQRGQPIVLGADPKGKNFLYTNG-NSVIIRNIENPAI-------ADVYTEHSCAVNVAKYSPSGFYIASGDASGKIRIWDTVNKEHLEFQPIAGPIKDISWSPDNQRIVAVGEGRERFGHVSETGTSVGEISGQSKSINSADFRPARPRIVTGSEDNTIAVFEGPPFKFKMTKQDHSRFVQAVRYSPDGKFFASAGFDGKVF---LYDGTSSELVGEFPAHKGGVYALAWKPDSTQLLTCSDKTCRLWTVESRELVSEVMGTTVDDQQVSCLWQGDNLITVSLSGVITYLNVADPSKPLRVVKGHNKPITVLGLSDDRSTIYTGSHDGVVTNWNSGSGT----------NDRITGTGHG----NQINGIAAWGDFVYTCGIDDSLRQFS 394
17 -60.800[S] KOG0293 WD40 repeat-containing protein  ali follow..  15  4..............................................................................................VEDTEPPLKRAKRLADEPNGFSANSSVRGSSVNSNSLGDLMARPLPSQGDDETIGSKGVIRKSEFVRIIT-------RALYSLGYDKTGAMLEEESHNSTIKLFLQQVKDGK-WDQSVKTLHRIGFPDEKAVKAASFLLLEQKF-----------LEFLKVEKIADALR-----RNEMAPLRINTKRVHELASSL-----------------------------------------------------------SPSSFISHTTSTPGKESVNSRSKVLEELQTLLPASVIIPEKRLECLNSLHIQRDSCVFHNTLDSDLSLYSDHQCGKHQ--------IPSQTAQILESHTDEVWFLQFSHNGKYLASSSKDQTAIIWEISADGHISLKGHHKPVIAILWSPDDRQVLTCGAEEV------------------------------------------IRRWDVDSGDCVHMYEKGGISPISCGWYPDGQGIIAGMTDRS---ICMWDLDGREKECWKGQRTQKVSDIAMTDDGKWLVSVCDSVISLFDREATV--ERLIEEEDMITSFSLSNDNKYILVNLLNQEIRLWNIEGDPKIVSRYKGHKRSIRSCFGGYKQAFIASGSEDSQVYIWHRSTGK---------LIVELPGHA----GAVNCVSWSPTNLMLASASDDGTIRIWG 560
18 -60.600[S] KOG0282 mRNA splicing factor  ali follow..  13  13......................................................................................................................GSGSGSESDSDSESSRCPLPAADSLMHLTKSPSSKPSLAVAVDSAPEVAVK--DLETGVHLDPAVKEVQYNPTYETM----------------FAPEFGPENPFRTQQMAAPRNMLSGYAEPAHINDFM--------------------FEQQRRTFATYGYALDPSLDNHQVSAKYIGSVEEAEKNQGLTVFETGQKKTEKRKKFKENDASNIDGFLGPWAKYVDE--------KDVAKPSEEEQKELDEITAKRQKKGKQEEEKPGEEKTILHVKEMYDYQGRSYLHIPQDVGVNLRSTMPPEKCY--------LPKKQIHVWSGHTKGVSAVRLFPLGHLLLSCSMDCKIKLWEVGERRCLRTFGHSKAVRDICFNTAGTQFLSAAYDRY------------------------------------------LKLWDTETGQCISRFTNR-KVPYCVKFNPDEDLFVAGMSDKKIV---QWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTSDKSLRVWEWDIPVDFKYIEPSMHSMPAVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKKGHMVAGYACQVDFSPDMSYVISGDGNGKLNIWDWKTTK----------YSRFKAHDKV----CIGAVWHPETSKVITCGWDGLIKLW. 578
19 -60.500[R] KOG2096 WD40 repeat protein  ali follow..  2........................................................................................................................................................................................................................................................................................................................................................................DSVLVVGIASVILGALIAVLFFGSYFRKRTSEVQSMAKAEPQDPIRNPKSNHPAPKKNHPKSQASDKNQNKRH--HPLDLNTLKGHGDAVTGLCFSSDGKSLATACADGVIRVFKLDDASSKSFLPAGGHPTAVAFADDASSIVVAC--------------------HHMSGSSLYMYGEDKQKDQQGKLPLPSIKWDHHHIHEKRSVLTISGATATYGTADGSVVIASCSEGTDIV---LWHGKTGRNLGHVDTNQLKNHMAAVSPNGRFLAAAATADVKVWEIVYQKRVMQLKGHKSAVTWLCFSPNSEQIITASKDGSIRVWNINVRPIPLCDSGGNPLHYDRLSLCPEGKILAASH-GSTLQWLCAETGNVLDT--------AEKAHE----GDITCISWAPKAMVLGTSGDDKKVKLWE 447
20 -59.700[S] KOG0296 Angio-associated migratory cell protein (contains WD40 repeats)  ali follow..  12  2.................................................................................................................................................................................................................................................................................................................................................................................................AEEEENQELYIAENEVEEVKLMDQGVTEDEAEQEQNDTMNNMVMDM-------SVQGFFEHKDSVFSVSINPVHNLCASGGGDDLGYIWDITTGEQICQLGHKDSIVAIDWSFDGTYIATGGMDSQVRLWKSSTGFEFITAFETVDEIVWLSWHPKGLFLAAGCNDGSIWMWSLPSGKVVQVMYGHTAPVNAGKFIPPGKRLATVDDSGTLI---VWNPATGAPECRMSETAAGWTSFDCNAEGNVLFLGGSGKVKVVNINSSHILASLEAQTESVEAIALCTALPICACASVDGTVALYDSASLK--FRKSLPHEQAVIDCKFLPNTPYLLTACADCVIRKWDVRSGQ---------LLGEYTGHQ----EPILCMAITPDGKRVVTGSDDTELLVFD 396
21 -59.600[R] KOG2394 WD40 protein DMR-N9  ali follow..  1............................................................................................................................................................................................................................................................................................MMNTSNGMISAPSSSSSPAANPQSPGIKTYFKTPEGKYKLHYEKTHSSGLLHYA---HGKTVTQVTIAQLKERAAPSTPTGTSSGYSASSGFRSATARLLSSRISGSFAASNSNTSMTNTNFDGKGTYLVFNVSDAIFI-------DLNSQEKDPVKSIHFSNSNPMCHAFAKDGHDLLIGLNSGDVYTVSLRQQLQ-SVNNRQDRCTSISWVPGGDGAFVVAHADGNLYN-------------------KDGATESTFPAIRDPTQFSVDKAKYSKSNPVARWHICQGSINSIAFSNDGAHLATVGRDGYLR---IFDFLTQKLVCGGKSYYGALLCCSWSMDGKYILTGGDDLVQVWSMEDRKVVAWGEGHNSWVSGVAFDSNWSRFGSVGQDTQLLLWDLEMDESPIIAHRVHTEPLSGLMFTQES--VVTACREGHIKIWTRPSESETQT------NSSEANPT----TALLSTSFTKDNKASLSSKIISGSTFK. 555
22 -59.400[B] KOG0639 Transducin-like enhancer of split protein (contains WD40 repeats)  ali follow..  75MHKQTEIAKRLNTSQEHQQQVAQAVERAKQVTMAELNAIIGQQQLQAQHLSHGHGPPVPLTPHPSGLQPPGIPPLGGSAGLLALSSALSGQSHLAIKDDKKHHDAEHHRDREPGTSNSLLVPDSLRGTDKRRNGPEFSNDIKKRKVDDKDSSHYDSDGDKS--------------------DDNLVVDVSNEDPSSPRASPAHSPRENGIDKNRLLKKDASSSPAST-----------ASSASSTSLKSKEMSLHEKASTPVLKSSTPTPRSDMPTPGTSATPGLRPGLGKPPAIDPLVNQAAAGLRTPLAVPGPYPAPFGMVPHAGMNGELTSPGA-------AYASLHNMSPQMSAAAAAAAVVAYGRSPMVGFDPPPHMRVP-TIPPNLAGIPGGKPAYSFHVTADGQMQPVPFPPDALIGPGIP-------RHARQINTLNHGEVVCAVTISNPTRHVYTGG-KGCVKVWDISHPGQLDCLNRDNYIRSCKLLPDGCT-LIVGGEASTLSIWDLAAP---------------------------------------TPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIA---VWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGDNTVRSWDLREGRQLQQH-DFTSQIFSLGYCPTGEWLAVGMESSNVEVLHVNKPDK--YQLHLHESCVLSLKFAYCGKWFVSTGKDNLLNAWRTPYGASI----------FQSKES----SSVLSCDISVDDKYIVTGSGDKKATVYE 767
23 -59.400[R] KOG0289 mRNA splicing factor  ali follow..  12  7............................................................................................................................................................................................................................................................ISNEVPEHPCVS---PVSNHV---YERRLIEKYIA--ENGTDPINNQPLSEEQ------------------------IDIKVAHPIRPKPPSATSIPAILKALQDE-------------------------WDAVMLHSFTLRQQLQTT-RQELSHALYQHDAACRVIARLTKEVTAA------REALATLKPQAGLIVPQAVPSSQPSVVGAGEPMDLGELVGMTPEIIQKLQDKATVLTTERKKRGKTVPEELVKPEELSKYRQVASHVGLHSASIPGILALDLCPDTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIR---IWSVPNASCVQVVRAHESAVTGLSLHATGDYLLSSSDQYWAFSDIQTGRVLTKVTTSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLK-ERTNVANFPGHSGPITSIAFSENGYYLATAADDSSVKLWDLRKLKNFKT-KQWTEILHFTEHS----GLTTGVAFGHHAKFIASTGMDRSLKFYS 503
24 -59.400[JT] KOG0643 Translation initiation factor 3, subunit i (eIF-3i)/TGF-beta receptor-interacting protein (TRIP-1)  ali follow..  12  5........................................................................................................................................................................................................................................................................................................................................................................................................LLQGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGE-------RLGTYMGHTGAVWCVDADWDTKHVLTGSADNSCRLWDCETGKQLALLKTNSAVRTCGFDFGGNIIMFST-------------------------------DKQMGYQCFVSFFDLRDPSQIDNNEPYMKIPCNDSKITSAVWGPLGECIIAGHESGELN---QYSAKSGEVLVNVKEHSRQINDIQLSRDMTMFVTASDNTAKLFDSTTLEHQKTF-RTERPVNSAALSPNYDHVVLGGGQEAMDVTTTSTFEEEFGRVKGHFGPINSVAFHPDGKSYSSGGEDGYVRIHYFDPQY----------EFEFEA.................................. 325
25 -59.300[S] KOG0308 Conserved WD40 repeat-containing protein  ali follow..  11  23.......................................................................................................................................................................................................................................................................................................................................................................................................EHEYSNRSAVSALQYDAQNGRLFTGGSDTIIRTWSVPHHKDKNSPVQYQGSLEQHTDWVNDMILCGHGKILISASNDTTVKVWNIERDNKHGFITHKDYVSCLAYAPIVEK-AVSASFDHNIFVYDINANFKTVLIGCKDSIYSLATTPNLSLVLGAGTEKCIRLFDPRTNEKIMKLRGHTDNVRALVVNDDGTRALSAGSDATIR---LWDIGQQRCIATCIAHEEGVWTLQVDSSFTTVYSAGDKMVVKTPLYDFTKSQLLFKEEAPVKKLLLSEKDNSLWVGTWKSDIKRWSIR-PSAQLSIGGDEDGPSTSNANHSVSASSSPPVTFKYIRVKDQKGQQSTPEL------------VIPGAPAIKKHAMLSDKRHVLTRDSDGNVALYD 419
26 -58.900[A] KOG1272 WD40-repeat-containing subunit of the 18S rRNA processing complex  ali follow..  11  2..........................................................................................................................................................................................................................................................................................................................EISSEDNNLMEKVLPPVEQVLT------WTLIQICMQESDVELETKVKKYLRGEGANLETLKDKKLKTQLASREKLYGKSAKAAAKIEKWLLPAEAGYLETEGLEKTWRVKQTDANEVDILSSRNQYDIVLPDFGPYKLDFTASGRHMLAGGRKGHLALLDMMNMSLIKEIQVRETVRDVAFLHNDQ--FFAAAQKKYAYIYGRDGTELHCL-------------------------------------------KERGPVARLRFLKNHFLLASVNMSGQLH---YQDVTHGGMVASIRTGKGRTDVMEVNPYNSVVGLGHGGTVTMWKPTSQAPLVQMQCHPGPVSSVAFHPNGHLMATSGKERKIKIWDLRKFEE---VQTIHSFHAKTLSFSQKGLLAAGTGSF--VQILGDSSGGSSHN------YTRYMNHSMVKGYQIEKVMFRPYEDVIGIGHSMGWSSILI 408
27 -58.200[S] KOG1407 WD40 repeat protein  ali follow..  18  10....................................................................................................................................................................................................................................................................................................................................................................................................................................................SLHSREYQGHKKKVHSVAWNSNGTKLASGSVDQTARIWNIEPHKDLELKGHTDSVDQLCWDPKHSDLVATASGDKSVRLWDARSGK------------------------------------------CTQQVELSGENINITYKPDGTHVAVGNRDDELT---ILDVRKFKPLHR-RKFNYEVNEIAWNMPGDFFFLTTLGTVEVLSYPSLKPLDTLTAHTAGCYCIAIDPKGRYFAVGSADSLVSLWDIS-DMLCLRTFTKLEWPVRTISFNYSGEYIASASEDLFIDIANVQTGR---------TVHQIPCRA-----AMNSVEWNPKYNLLAYAGDDKNPKYNT 302
28 -57.900[S] KOG2106 Uncharacterized conserved protein, contains HELP and WD40 domains  ali follow..  15.........................................................PPPGSGKILLCQQPKVTSRGPALLNECLLGVEGKAMGIPEETGIAQAPPAALPVAKKNSESKPKEPVFSAEEGYVKLFLRGRPVTMYMPKDQVDSYSLEAKVELPTKRLKLEW------YGYR--GRDCRNNLYLLPTGETVYFIAS-----VLYNVEEQLQRHYANDDVKCLAVHPDRIIATGQVAGTSKDGKQLPPHVRIWDSVT------------------LNTLHVIGIGFFDRAVTCIAFSKSNGGTNLCAVDDSNDHVLSV---------------WDWQKEEKLADVKCSNEAVFAADFHPTDTNIIVTCGEITSLLLDTRRKLPLIRSKRKAKVVLCVTFSENGDTIT-GDSSGNILVWGKGTNR------ISYAVQGAHEGGISPLCMLRDGTLVSGGGKDRKLISWSGNYQKLRKTEPEQFGPIRTVAEGKGD-VILIGTTRNFVLQGTLSGDFTPITQGHTDELWGLAIHASKPQFLTCGHDKHATLWDAVGHR-PVWDKIIEDPAQSSGFHPSGSVVAVGTLTGR---WFVFDTETKDLVTVHTDGNEQLSVMRYSPDGNFLAIGSDNCIYIYGVSDNTRVGKCSGHSSFITHLDWSVNSQFLVSNSGDYEILYWVPSACKQVVSVEGSDGTDINAVCRAHEKKLLSTGDDFGKVHLFSYPCSQFRAP------SHIYGGHS----SHVTNVDFLCEDSHLISTGGDTSIMQWR 715
29 -57.600[T] KOG0279 G protein beta subunit-like protein  ali follow..  14  1...............................................................................................................................................................................................................................................................................................................................................................................................MAEGLVLKGTMCAHTDMVTAIATPVDNSDIVTSSRDKSIILWKLTKEDKS--YGVAQRRMTGHSHFVQDVVLSSDGQFALSGSWDGELRLWDLATGESTRR-----------------------------------------------------------------------------------FVGHTKDVLSVAFSTDNRQIVSASRDRTIKLWNT-LGECKYTISEADGHKEWVSCVRFSPNTLVPTIVSDKTVKVWNLQNCKLRNTLAGHSGYLNTVAVSPDGSLCASGGKDGVILLWDLA-EGKKLYSLEAG-SIIHSLCFSPNRYWLCAAT-ENSIRIWDLESKSVVEDKTDGSTGIGNKTKVIY----CTSLNWSADGNTLFSGYTDGVIRVWG 322
30 -57.500[A] KOG0284 Polyadenylation factor I complex, subunit PFS2  ali follow..  11  7................................................................................................................................................................................................................................................................................................................RGNQMPNVTLTIQPSTSSMQNSQPRIMNNHHHPH------------NRFQREHVMPDVMGDGPGRRLRKNVANVRRHVDYVSTVCENRLWQYGKQRILQQPDILYQQYAVPADSTPDVPVDCILTK-------FIRTAMNKVKCPVYSVCWSPEGKRLITGCQTGEFTLWNGTAFNFETILAHDSAIRALKWASNEQWLLSADQGGYVKYWQPNMNNAHMFSAHKDEAIRGLAFAPTDVKFATASDDGTARVWDFARYTEERVLRGHGAEVRCIDWHPTKGLIATGSRDTQ-QPVKIWDPKSGSCLATLQEHKSSVMAVEFNKNGNWLLTGGDHLVKMYDIRMMKEMRTYRAHKKEVISLAWHPIHELFVSGGGDGSIVYWMVDGEKEIGLLEHAHDQAIWSMKWHPLGHILATGSNDNNTKFWARNRPGDTVEDIFGLSNTNMIGHLDK----EREPRMAPPKPSIETQETYRPDTFI. 467
31 -57.100[S] KOG0283 WD40 repeat-containing protein  ali follow..  10  1MEDGNKLDRKKTMTMNWEGLGDFEDEDDDR-ETHDRLSSALTFDMANASSSDEDEDFDDCRLSFSSAVSSLTTASRKFRTPAMSPDYDIWMAAPGSISERRRRLLHGMGLASNKDMVSAVSIRRVVSNAPVVSNGEEKKMKKKMNHEVDEQDHDHVPVMLARSRS----------------ESDIERFLIEKRRKEEILGKISKQRLTRTYSTICPTRTRICQYQTPIRQTPAVCGNGKALRGGGEALTSVMSNARVGAFFLIKNLDTGKEFIVNEYDEDGMWNRLSDLQTGKQLTLEEFEKCVG----------YSPVVKELMRRENVNRINYEPLMDLRKFNSYLSKSVRLSKRRGAALLKNIKGVAHSMSLR------------------VADKDVSDGSTDSPKKGKDHKHGKANEWVKVRPTGKSYKELSALHMCQEIQAHEGAVWTIKFSQDAHYLASGGADRVIHVWEVQECELMSMNGSLTPIHPSLCDSSGNEITVVEKKKKGKGSSGRRHNHIPDYVHVPETVFSF------------------------SDKPVCSLKGHLDAILDLSWSKSQL-LLSSSMDKTVR---LWDIETKTCLK-LFAHNDYVTCIQFSPDENYFLSGSDAKIRIWSIQDRH-VVEWSDLHEMVTAACYTPDGQGALIGSHKGICRAYDTEDCKLSQNKKSQAKRKITSFQFSPVNPEVLVTSADSRIRILDGSEVIHKFK--------------FRNTCSQLSASYSQDGKYIICASEDSQVYLWK 710
32 -57.100[R] KOG0315 G-protein beta subunit-like protein (contains WD40 repeats)  ali follow..  1....................................................................................................................................................................................................................................................................................................................................................................................................................MGDQQQLILATGGYDHTIKVWQAHTGN------CIKTMRFVETSQVNALDRTPDKTRLAACGYQ-CIRLYDLESNCTAPVIGVQKNVTRLGFQEDGNW-MFTAGEDHHVRIWDMIAAPPSRIFDCEAPVNAACLHPNQVEIAMGSQNGSVFLWDVKSERHERIVPEVDASIQDVAISPDGRYLAAANNKGNCYIWSL-KMSTLRPNRKIPAHSRYILRCKFSPDSRLLLTTSDGTVCIWKTDDFSKWRELCIENYWVWDAAFSADSKWLFTASSDGIARLWKLQ-TKSSIRDYTGHTKAITALSFKDEIPVKSTNISDVQSSAKPPTQ---------------RDNPP----GTNNLAFFETVGRVAMNPYMGNTTTEL. 361
33 -56.900[T] KOG4378 Nuclear protein COP1  ali follow..  12  1................................................................................................................................................................................................................................................................................................................................................................................................................MMSNLVEPSWRLLAASGGD-TVKLFDVSADS----DPCVLSYTPSPGCAVNSVKWNHTNLVVASTGEDKKISLWRKNGQSLGTV-SAEECLSAISFSKKGSRYICSGGTGQIVKIW-----------------------------------------DLQRKLCIKKLKGHTSTITGVMYNCKDEHLASVSVGGD---LIVHNLASGARATELKDPNGQLRLLDYSRSSRHLLVTADGTVHLWDTTGRSPKMSLKQHSAPTAGVCFSPSNEKIASVGMDKKLYTYDS--GSRRSSSCIAYEAPFSSLAFGDNGYILVAGTSNGRVVFYDIRGKPQ--------PVTVLHAFS--NSEDVTSLSWQTSKPVIVNEKNYTSEMALL 343
34 -56.600[S] KOG0316 Conserved WD40 repeat-containing protein  ali follow..  14  2..............................................................................................................................................................................................................................................................................................................................................................................................................................................SATELPTKEAHILKGHEGAVLAARFNGDGNYALTCGKDRTIRLWNPHRGILIKTYSHGREVRDVHVTSDNAKFCSCGGDRQ------------------------------------------VYYWDVSTGRVIRKFRGHDGEVNAVKFNDSSSVVVSAGFDRSLR---VWDCRSHSVEPVQIIDTFLDTVMSVVLTKTEIIGGSDGTVRTFDMRIGREMSDNLGQP--VNCISISNDGNCVLAGCLDSTLRLLDRT-TGELLQVYKGHISKKTDCCLTNSDAHVIGGSEDGLVFFWDLVDAK---------VLSKFRAHD-----LVNSIDVDFYLRKFFVAGDKRELPPEG 299
35 -56.300[A] KOG0640 mRNA cleavage stimulating factor complex; subunit 1  ali follow..  14  27...............................................................................................................................................................................................................................................................................................................................................................MYDGLEKFAMELSMLVKADQCAPSERLLHVMIAQTLSDKDKTNSDDVLPGIDLEFEPEASALAPEPHSYETA------------------YVTSHKQACRAGAFSCDGSLVATGSVDASIKILDVERMLAKSAPDHTDEVSYLEFHPKEH-ILASASRDGTVKLFDIAKPSV---------------------------------------KKAHKVFTDCEPVLCLSFHPTGDYVAIGTEHNVLRVYDVATTQCFVSAIPSQQHKAGVTCVKYSPTGKLYATGSDGDIKIWDGISGRCINTIAEAGAAICSLEFTRNGKYLLSSGMDSLVYLWELC-TSRPIQTYTGQEHQTEAVFNHTEDYVLFPDEATTSLCSWNSRNGCRLT--------LNSLGHN----GPVRYITHSPNGPAFLTCSDDFRARFWY 418
36 -56.300[D] KOG0267 Microtubule severing protein katanin p80 subunit B (contains WD40 repeats)  ali follow..  12  2........................................................................................................................................................................................................................................................................................................................................................................................................SLCGHTSPVDSVAFNSEEVLVLAGASSGVIKLWDLE-------ESKMVRAFTGHRSNCSAVEFHPFGEFLASGSSDTNLRVWDTRKKGCIQTYGHTRGISTIEFSPDGRWVVSGGLDNV------------------------------------------VKVWDLTAGKLLHEFKCHEGPIRSLDFHPLEFLLATGSADRTVK---FWDLETFELIGTTRPEATGVRAIAFHPDGQTLFCGLDDGLKVYSWEPVICRDGVDMGWSTLGDF-CINEGKFIGCSYYRNSVGIWVSDISE---VSEDKNECMVKRFSVLNDQSERMGSGPRGSVSP-------------------------DYETREIKNIYVDSTGGNLNVAQNPGSLKATL 319
37 -55.600[R] KOG0288 WD40 repeat protein TipD  ali follow..  14  142..............................................................................................................................................................................................................................................................................................................................................................EEMTSRVQKAETENKMLIDRWMLQKMQDAE-RLNEANDLYEEMLAKLKANGLETLARQQVDGIVRRNEDGTDHFVESTI------PSTCANRIHAHEGGCGSIVFEYNSGTLFTGGQDRAVKMWDTNSGTLIKSLGSLGNILDMAVTHDNKSVIAATSSNN------------------------------------------LFVWDVSSGRVRHTLTGHTDKVCAVDVSKFSRHVVSAAYDRTIK---LWDLHKGYCTNTV-LFTSNCNAICLSIDGLTVFSGHDGNLRLWDIQTGKLLSEVAGHSSAVTSVSLSRNGNRILTSGRDNVHNVFDTR-TLEICGTLRASGNRLASSCISPDDDYVAAGSADGSVHVWSLSKGN----------VSILKEQT----SPILCCSWSGIGKPLASADKNGYVCTWT 515
38 -55.300[U] KOG0277 Peroxisomal targeting signal type 2 receptor  ali follow..  16  1...............................................................................................................................................................................................................................................................................................................................................................................................................................................MSAVCGGAARMLRTPGRHGYAAEFSPLPGRLACATAQGTLLILDPDEARLFRSFDWNDGLFDVTWSENNEHVLITCSGDGSLQLWDTAKA----------------------------------------AGPLQVYKEHAQEVYSVDWSQTRGLVVSGSWDQTVK---LWDPTVGKSLCTFRGHESIIYSTIWSPHIPGCFASADQTLRIWDVKAAGVRIVIPAHQAEILSCDWCKNENLLVTGAVDCSLRGWDLRNVRQPVFELLGHTYAIRRVKFSPHASVLASCSYDFTVRFWNFSKPDSL--------LETVEHHTEF----TCGLDFSLQSPQVADCSWDETIKIYD 315
39 -55.200[S] KOG1409 Uncharacterized conserved protein, contains WD40 repeats and FYVE domains  ali follow..  11  2.........................................................................................................................................................................................................................................................................................................................................................................................................................AAIINQRVEQGESSMGGAKPALLH--------RITGHVARINDVILLSKDEGVWTASDDRSVRLYLKRDNDQFWPSFMPVAPTSLYYSEETYKLLVGLINGNVYE--------------------------------------FSVADDFNSMTESRKWTCHAGPISGLGFALSSELIFSCSRDKS---IVWHCSENSN---KMGSYLLENSCTAMVIDLPFVFVGDGGHVTVLRIVDNQLVSKLSAHTNAITSLTWDGNKKVLYSGSSDHLIIMWDIGGGRGEAYELNGHNGKVTTLCAAPAAKRLFSADEHGKLMCWDMNCKRDNPQNFNLTPLAIPHEIH----TGITAMHLQETLGLLVTSGQNRVIMIW. 402
40 -55.000[ABO] KOG1446 Histone H3 (Lys4) methyltransferase complex and RNA cleavage factor II complex, subunit SWD2  ali follow..  18  12...................................................................................................................................................................................................................................................................................................................................................................................................................................................SFKVAKIFRENTDKINAIDFAPNGEHLISCSEDDQIVIYDCEKGTQSRTVSKKYGVDLIHFTHANNTAIHSSTKVDDTI----------------------------------------RYLSLHDNKYLRYFPGHTKKVISLCISPVEDTFLSGSLDKTLR---LWDLRSPNCQGLMHLSG--RPIAAYDPEGLIFAAGVSESIKLYDLRSFDTFKLNQEKECDWTGLKFSRDGKTILISTNGSVIRLVDAF-HGTPLQTFTGYPNNPIEASFSPDSQFIFSGSTDGRVHIWNADTGN---------KVSVLNGD---HPGPVQCVQFNPKYMMLASACTNMAFWLPT 312
41 -55.000[R] KOG1524 WD40 repeat-containing protein CHE-2  ali follow..  1................................................................................................................................................................................................................................................................................................................................................................................................MKLKLSASRKTRHTEMVCGVGWIGTEA-ILSAADDHVFLLTNTATNESQQINGKVENMVDAHNGAALCARWNSDGTGLLSSGEDGFVKMWSRSGMLRSVLAQFATAVYCVAWDSTSSN-VLYCNADHCYIKSLKMQVAPIKWKAHDGIILCCDWNPTSDLIVTGGEDLKFKVWD-GFGQILFNSSVHDYPITSISWNTDGTLFAVGSHN----ILRLCD-KSGWSHSLEKMNAGSVMALSWSPDGTQLAVGTAGLVFHAHIIDKRLPPGQVMALLDERKIDLANDTLVVRDRADNKVLHFFDPTTGKAQGDGNLKHEHDIVELTVNQCGRNVAFRDQIGAVHIAMVKTFG---------VSQRMVKIG----SLVEQLVFNDVTNMLCGIS-EGKIAVW. 530
42 -54.500[A] KOG0268 Sof1-like rRNA processing protein (contains WD40 repeats)  ali follow..  13  2...........................................................................................................................................................................................................................................................................................................................................................................................KVKMLSRNPDNYVRETKLDLQRVPRNYDPALHPFEVPREYVRAL----ATKLERVFAKPFLASLDGHRDGVNCLAKHPEKATVLSGACDGEVRIWNLTQRNCIRTIAHEGFVRGICTRFCGT-SFFTVGDDKTVKQWKMDGPEEEPLHTILGKTVYTGIDHHWKEAVFATCGQQVDIWDEQRTNPICSMTWGFDSISSVKFNPIETLLGSCASDRN---IVLYDMRQATPLKKVI-LDMRTNTICWNPMEAFIFTAADYNLYTFDMRADTPVMVHMDHVSAVLDVDYSPTGKEFVSASFDKSIRIFPVDKSRSREVYHTKRMQHVICVKWTSDSKYIMCGSDEMNIRLWKANASE---------KLGVLTSREKARRKEVNRIKHSKPGSVPLVSEKKKHV-VAV 443
43 -53.800[A] KOG0272 U4/U6 small nuclear ribonucleoprotein Prp4 (contains WD40 repeats)  ali follow..  16  105...........................................................................................................................................................................................................................................................................................................EMEMERDKVALLEEFERKKRARQINVSTDDTEIKSNLRQLEGPAERRRRLKELLAGLGENAINKRQYEDEERKQQQREQDQATWYHEGPDSLRIARSLPRAKDRLVRAREALEVPSAARAGRMVEMQKKLQ-----SLAPLCSQVGDTRPVSSAAFSEDSSLLLTSSWSGLCKLWSVPDCELKQTLGHASYVGGVALRPGVK-----------------------------------ADEENVVAMASGGHDGAVKLWGFNNEESIADITGHPHRVSKVAFHPSGRFLATACYDSSWR---LWDLEQKTEVLHQEGHAKPVHCLSYHSDGSVLVTGGDAFGRVWDLRTGRCIMFLEGHLGAVFGVDFSPNGFHIATGSQDNTCKIWDLR-RRQPVYTIPAHTNLISDVKYQQEGSFLVTCSYDSTTKIWSNKTWQ---------PLKTLQGHDNK----VISVDIAPNSQYIATTSFDRTFKLWS 550
44 -53.800[R] KOG1539 WD repeat protein  ali follow..  41..................................................................................................................................................................................YNCAKLNLVIPKLPKKIRALASYRD-----NEIAVFRRAHQVATWSKHVAKVDLLLGEHVLSLDVEGNMFIWAFKGIEIGNLQLTGKFTPTSIVHPDTYLNKVLVGSQEGPLQLWNINTKKMLYQFKGWGSSVTSCVSSPALDVVAIGCADGKIHVHNIKLDEEIVTFEH-----ASRGAVTALSFSTDGRPLLASGGSFGVISIWNLNKKRLVIRDAHDSSIISLNFLANEPVLMSASADNSLKMWIFDTND----DPRLLRFRSGHSAPPLCIRFYSNGRHILSAGQDRAFRLFSVIQEQQSRELQRHISRRAKKLRLKEEELKLKPVVS-FDCAEIRERDWCNVVTCHMDTAEAYVWRLQNFVLGEHILKP-CPENPTPIKGVFVSRNHLLLAILACAISACGNFAVVGTAGGWIE---RFNLQSGISRGSYYAHDGEVIGVACDSTNTLMISAGHGDLKVWDFKKRELKSQWDVGCS-LVKIVYHRVNGLLATVADDFVIRLYDVV-TLKMVREFRGHTDRITDLCFSEDGKWVISSSMDGSLRIWDVILAKQI--------------DGVHVDVPITALSLSPNMDVLATAHSDQNVYLWV 648
45 -53.700[R] KOG1334 WD40 repeat protein  ali follow..  18VASLILATQNPDSVQPFGYCSGAKKLSDVRILWRTIGASEVKLFPYRDKNDHQHLPEGVSNKDFQSGATRKLLLPGVPDQLQQTSFEMSHQEGSTGGLPDLVTESLFSSPEEQSGVAAVTAASSDIEMAATEPSTGDGGDTRDGGFLNDASTENQNTDSESSS--------EDVELESMGEGLFGYPLPRMCPRCGGTNHDQCLLDEDQALEEWISSETSALPRSRWQVLTALRQRQLGSSAR-------------------------VYEACGARTFVQRFR----------------------------------------------------------------------------------------------------------LQYLLGSHAGSVSTIHFNQRGTRLASSGDDLRVIVWDWVRQK------PVLNFESGHDINVIQAKFFPNDSTLAMCGHDGQVRVAELINASYCENTKHRGPAHELALEPDSPYKFLTSGEDAVVFTIDLRQDRPTRENDKKVGLYTISMNPANIQFAVGGHDQFVRIYDQRRIDHHLVYCDFPTNITCVVYSHDGTELLASYNDEDIYLFNSSLSDGAQYVKRYKGHRNNKCVNFYGPRSEFVVSGSCGHVFFWEKSSSQIIQFMEGRGDIVNCLEPHPYLPVLATSGLDQHVRIWTP--TAKTATELTGLKDVIKKNKQERDEDNLNYTDSFDNRMLRFFVRH-----------LLQRAHQP----GWRDHGAEFPDEEELDESSSTSDTS... 668
46 -53.600[Z] KOG1523 Actin-related protein Arp2/3 complex, subunit ARPC1/p41-ARC  ali follow..  10  2.......................................................................................................................................................................................................................................................................................................................................................................................................SLHQFLLEPITCHAWNRDRTQIALSPNNHEVHIYKKNGSQ------VKAHELKEHNGHITGIDWAPKSDRIVTCGADRNAYVWSQKDGVTLVILRINRAATFVKWSPLENKFAVGSGARLISV--------------------------------------CYFEAENDWWVSKHIKKPIRSTVLSLDWHPNNVLLAAGSCDFKCRVFSA-PFGQLMSEFGGSGTGGWVHGVSFSASGSRLAWVSDSTVSVADASKSVQVSTLKTEFLPLLSVSFVSENSVVAAGH-DCCPMLFIYD-DRGCLTFVSKLDIPKQSIQRNMSAMERFRNMDKRAT--------------TEDRNTALETLHQ----NSITQVSIKQDCRKFCTTGIDGAMTIWD 356
47 -53.400[T] KOG1354 Serine/threonine protein phosphatase 2A, regulatory subunit  ali follow..  11  1............................................................................................................................................................................................................................................................................................................................................................................................................................MAGAGGGNDIQWCFSQVKG-------AVDDDVAEADIISTVEFNHSGELLATGDKGGRVVIFQQEQFDYLKSLEIEEKINKIRWLPQKNAAQFLLSTNDKTIKLWKISERDKRPEGYNLKEEDGRYRDPTTVTTLRVPVFRPMDLMVEASPRRIFANAHTYHINSISINSDYETYLSADDLR----INLWHLEITDRSANMEELTEVITAAEFHPNSCNTFVYSKGTIRLCDMRASALCDRFSEIISSISDVKFSHSGRYMMTRD-YLSVKIWDLNMENRPVETYQVHEYDKFECCWNGSDSVVMTGSYNNFFRMFDRNTKRDITLEAGKRKKDEISVDSLDFNKKILHTAWHPKENIIAVATTNN-LYIFQ 443
48 -53.400[S] KOG0772 Uncharacterized conserved protein, contains WD40 repeat  ali follow..  12  2..............................................................................................................................................................................................................................................................................................................................DDNTAPKKNSEKKARVFDLQA--QTISNAPRTEEPTHVPQSVSVSSKSESGVSSSAVSDDEDDFMP-DLPPGFQMQQSEAGPSSSRAEGPEDSDDSDFDETEAISII-------KLIPAACEAKISHGTQAISALRVEPPGVRFASGGLDYYVKLFDFQKMDMSMRYAESHVINSLAFSPNGE-TLVVASGEAIIRLLDRAGKQWSETVRGDQYI-----------------------------IDLNITKGHTATVNCVEFNPLNKEFISCSDDGSLR---LWNLDDHKVIKGANGKRVSPQVCTFSPDGKWIAAGCDGSVQAWKYGSQYVYLVRKAHNGSITSIAFSPDSKRLLSRGFDDTLKMWSLDNPKEPVKTGLENAFKSTDCGFSPRAEVVFTGTTPGTLQFFDPMTFD---------LVYKIDYPG----ISCHRIQWHPRLNQIIAGLSDGTIHVY. 445
49 -52.200[Z] KOG0313 Microtubule binding protein YTM1 (contains WD40 repeats)  ali follow..  16  24........................................................................................................................................................................................................................................................................................................................................................................................IPAASEIADLSNIINKLLKDKNEFHKHVEFLIKGQFLRMPLDKHMEVENISSEEVVEKCTAPQPEQCMFHDDWISSIKGAEEW--ILTGSYDKTSRIWSLEGKSIMTIVGHTDVVKDVAWVKKDSCLLLSASMDQTILLWEWNVER-------------------------------------NKVKALHCCRGHAGSVDSIAVDGSGTKFCSGSWDKMLKIWSTVPGLTRTPIVTLSGHMEAVSSVLWSDAEEICSASWDHTIRVWDVGSGSLKSTL-TGNKVFNCISYSPLCKRLASGSTDRHIRLWDPRTKDLVSLSLTSHTGWVTSVKWSPTHEQLISGSLDNIVKLWDTRSCK--------APLYDLAAHEDK----VLSVDWTDTGL-LLSGGADNKLYSYR 413
50 -52.100[S] KOG0281 Beta-TrCP (transducin repeats containing)/Slimb proteins  ali follow..  13  155......................................................................................................................................................................................................................................................................................................................................................................................................QYLFKNRPTDGPPNSFYRSLYPKIIQDIETIESNWRCGRHNLQ--------RIQCRSENSKGVCLQYDDEKIISGLRDNSIKIWDKTSLECLKVLGHTGSVLCLQYDER---VIVTGSSDSTV-----------------------------------------RVWDVNTGEVLNTLIHHNEAVLHLRFSNGL--MVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDF--DDKYIVSASDRTIKVWSTSTCEFVRTLNGHKRGIACLQY--RDRLVVSGSSDNTIRLWDIE-CGACLRVLEGHEELVRCIRF--DNKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHS----GRVFRLQF--DEFQIISSSHDDTILIWD 484
51 -52.000[R] KOG2055 WD40 repeat protein  ali follow..  11  2........................EKDTEELELENAVFGNINNFSSFLDKENETFDVMMNEAPELSEDNDAQEDELEKLEDAELFMFDTGSADGAKDSVPLDIIAGDNTVKEDEEASNEIPSI---------------------------EDSDDERLMIS---------------LQDHSRLRKLRQYEDEDMVN------------LQYARRLRTQFERVYPVPEWAKKQDVTEEEDEFNALSEKSVIPKSLKSLFKSSVSYINQSSKLLAPGTINIKRLKDA----------------------------------------------------------------------------------------------------------NFQAPSHSGIRCMSIHPYFPLLLTCGFDRTLRIYQLDGK-----VNPLVTSLHLRSSALQTALFHPDGKRVIAAGRRKYMYIWDLESAQVQKVSNFQPSMERFHVDPTGKYIALEGRSGH------------------------------------------INLLHALTGQFATSF-KIEGVLSDVLFTSDGSEMLVLSYGAE---VWHFNVEQRSVVRRWQVQDGSTTHFCLDPSNKYLAIGSSGIVNIYDLQTSKPVTTLDNITFSINSMSFSQDSQVLAIASKKDTLRLVHVPSFSRNWPTSATPLGRVTCLAFGKGG-ELCVGNEAGRVGLWKLAHYD---------LKFVPDKII------NWEIRLGKFGYVLLGIHVDVVI.... 555
52 -51.900[S] KOG0321 WD40 repeat-containing protein L2DTL  ali follow..  13  120......................................................................................................................................................................................................................................................................................................................................................................................................SECLMMLNQLPFCLGFANNESLLAVCTETGALELFDSRFYDENQPSARRIHGWLAHNNAIFSVNFSKDDSLLATSSGDQTSKVFDLSTQQCITRLYHSHSVKQVNFCNDSPYNLVSCSRDGSIIFWDMRTHGITIDGEHFQ-------------------------KPVLRIRKAHENSGRDCSITSATWLPQSTVISSCSANSALK---LWDLRTVHTVRPLSKRDFGVTNVCTSPDGERIYAASDSIIYEYSSRHLNYKDPRLRISSFYVKLACSPDGATLACGGKTSGVVVFDTTRNSSSAMLTGGHTKDVTAVDWSSEGQ-LASISDDGSVRVWNSSLHGSAAN--------LREKNF----SEIFYWGFSEK................. 490
53 -51.900[R] KOG1273 WD40 repeat protein  ali follow..  11  20..........................................................................................................................................................................................................................................................................................................................................................................................................YLEHGVIKCVAFNHRGSLLAAGCADGGCVIWDFETRGI-------AKEIRDNSAAITSVSWSKYGHRLLVSAADKSLTLWDVSTGEKIARTILQQTPLQARLNPGLSSPSLC------------------LACPLSSAPMIVDFDIDCTTLLPVSVPEMPDVLA-PPQRSKCPESNPPFSPAAACFNKCGDLVYIGNSKGE---ILIVDYKSVRVLALVSSGAAPVKNIVFSRNGQYLLTNSDRTIRIYENLLPAKNKMKTVTKMHWKAPCFSGDGEWVVGGSGEHKIYIWD--RAGHLVKILEGPKEALIDLAWHPVHPIIVSVSLAGLVYIWAKDYTEN---------WSAFAPDFKE----EENEEYVEREDEFDLIPETEKVKVLD 388
54 -51.900[U] KOG1332 Vesicle coat complex COPII, subunit SEC13  ali follow..  14  7........................................................................................................................................................................................................................................................................................................................................................................................................................................................TVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWREENG--------------------------------------TWEKSHEHAGHDSSVNSVCWAPHGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVKRFASGGDNLIKLWKEEEDKEEQKLEAHSDWVRDVAWAPSTSTIASCSQDGRVFIWTCDDASSSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKESVDGQ-------VCISDVNKGQ---GSVSASVTEGQQNE............... 321
55 -51.500[U] KOG0771 Prolactin regulatory element-binding protein/Protein transport protein SEC12p  ali follow..  10  4...................................................................................................................................................................................................................................................................................................................................................................................................................................................NQQPPSNLQTYGVPIYAVDWILEEAVRSKITKDQDDDDDDGSSSSSYIVLSGGGG-EGRSGIPNVILICRVDLHTNSL-----SEQPIGRRVIGTDLPYRMAIHPRQGGLICALPENIIEDDNEEESEKVVKELKDVGQQLSLSFNQDGTVLATGAEDGTLR---VFEWPSMKTLLNESKTHASVKSLTFSESGKFLVSLGAPLCRVWDVNASAAIASLSKEKDEFASCRFSVDNSVAANTQRGGSIITWDTTSWRRRSSKLIKRNNSISAFNVSADGKLLAVGTLEGDVLIIDSTKMQTNQI--------VKKAHL----GLVTALTFSPDSRCLVSVSFDSRARLTV 346
56 -51.500[R] KOG4497 Uncharacterized conserved protein WDR8, contains WD repeats  ali follow..  11  1......................................................................................................................................................................................................................................................................................................................................................................................................MNFSEVFKLSSLLCKFSPDGKYLASCVQYRLV---------VRDVNTLQILQLYTCLDQIQHIEWSADSLFILCAMKRGLVQVWSLEQPEWHCKIEGSAGLVASCWSPDGRHILNTTEFHLRITVWSLCTKSVSYIKYPKACLQGITFTRDGRYMALAERRDYVSIFVCSDWQLLRHFDTDTQDLTGIEWAPNGCVLAVWDTCLEYKILLYSLDGRLLSTYSAYEWSLGIKSVAWSPSSQFLAVGSDGKVRILNHVTWKMITEFANPKMGIGMLAFSPDSYFLATRNDNNAVWVWDIQKLR--LFAVLEQLSPVRAFQWDPQQPRLAICTGGSRLYLWSPAGCMSVQV-------------PGEGDFAVLSLCWHLSGDSMALLSKDHFCLCF. 442
57 -51.000[S] KOG4328 WD40 protein  ali follow..  10  1............................................................................................................................................................................................................................MATEYERKRLENIRRNDEMLAALNVRAKASSLLSAAKRSRDDSKSFKKKKPKPASTPTVIRMSLRTRGLNPDSAGLPDGFSDFRMGSQITHNQPSPQKQSPRLLAPIPFESAYE------GYGSYTQLVDTLLGIESKSCRGKLVKGEIGVVKDENESPMVRTRSSSRVSKVSVKKEEPEDDSFSDYVNKEFSIPVKPEKIEF-------DLDLLTLEPQNVARVVPGRIFVVQFLPNVKMVAAGDKLGNVGFWNLDCGNIYLFTPHSAPVSSIVFQQNSLSRVISSSYDGLIRLM------------------------------------------DVEKSVFDLVYSTDEAIFSLSQRPNDQSLYFGQDYGVFN---VWDLRAGKSVFHWELHERRINSIDFNPQNPHVMATSDGTACLWDLRSKPKTLSTVNHSRAVHSAYFSPSGLSLATTSLDNYIGVLSGA-NFENTCMIYHNNTSKFKAVWGWDDSYIYVGNLSKKIDVINPKLKR---------TVMELHNPLQRA---PCRIHCHPNVGTLAGSTAGGQVYVWT 514
58 -50.700[D] KOG1036 Mitotic spindle checkpoint protein BUB3, WD repeat superfamily  ali follow..  13  6...................................................................................................................................................................................................................................................................................................................................................................................................................................................PSAGRELSNPPSDGISNLRFSNNSDHLLVSSWDKRVRLYDVSTNSLKGEFLHGGAVLDCCFHDDFS--GFSVGADYKVRRIVFNVGKEDILGTHDKAVRCVEYFDF----------------------------SILFFYTLCLFCDVTGQVITGSWDKTVKCWDP-RGASGPERTQVGTYLQPERVYSMSLVGHRLVVATGRHVNIYDLRNMSEQRRESSLKYQTRCVRCYPNGTGYALSSVEGRVAMEFFDLSERKSEAGRDIVYPVNSIAFHPIYGTFATGGCDGFVNIWDGNNKKR---------LYQYSKYP----TSISALSFSRDGQLLAVASSYTAIFVRS 336
59 -50.600[YU] KOG2445 Nuclear pore complex component (sc Seh1)  ali follow..  13  2......................................................................................................................................................................................................................................................................................................................................................................................................QPFDSGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDT----NWELSDSWRAHDSSIVAIDWASPGRIIASASYDKTVKLWEEDPDQLCTLNDSKGSLYSVKFAPAHLGLKLACLGNDGILRLYDALEPSDLRSWTLT---------------------------SEMKVLSIPPANHLQSDFCLSWCPSRPEKLAVSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSYQLIATGCDGRIRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKA-NLQVELLSEHDDHNGEVWSVSWNLTGTILSSAGDDGKVRLWKATYSNE-------KCMSVITAQQ................................ 349
60 -50.200[T] COG5170 Serine/threonine protein phosphatase 2A, regulatory subunit  ali follow..  13  1...........................................................................................................................................................................................................................................................................................................................................................................................................................MDDIEDSLDQWKFAQCFGDKGDVED-------ITEADIISAVEFDHTGDYLATGDKGGRVVLFERNHSKYLKSLEIEEKINKIRWCKRTNRAHFLLSTNDKTIKLWYEKNLKVVAENNLSDSFHSPMQGPLTTPSQLRLPRLNHHDMIIAAYPRRVYAAHAYHINSISVNSDAETYISADDLR----INLWNLSISDHSENMEELTEVITSAEFHPINCNHLMSSKGNIKLLDLRQSALKSFFSEIISSISDVKFSQNGRYILSRD-YLTLKIWDVNMEKAPVKTIPLHDVDKFECTFSGDDKHVLSGSYSNNFGIYPTDSSLPGDRGQIVLQAVGLDPDNLDYNKKILHASWHPFEDSVAIAATNN-LFVFS 461
61 -49.800[S] KOG0310 Conserved WD40 repeat-containing protein  ali follow..  2.....................................................................................................................................................................................................................................................................................................................................................................................AQPYLPAEKFLSRKQETILLDEDEPAVVSSVRISPKKPYHVATTSSVRLTLYDTVVCEP-------LNLFSRFKKGVCSIDFRHDGRLLAIGGDEGKVRIFDVEKTTLRVMQASQSTVKSVHFSPRGD-TVFSMADDGKIKQYRVADTAYG-----------------------------------VNAVPIIEIQAHEDAIRCGAVSSNDHIVLTGGYDHKVR---LWDIRSKEKSLEL-DCEHPVESVLFLPGEQLIATAAGPIVKIWDTTTGRQLTALQAHYKTVTSLRLATNSTCLLSAGIDRRVNAFRTT-NYSLINSWS-MPSPVLDIDVSRDDQTMAIGMGNLLALYRRAEIKKEATASAKNADKLKIPKIDGM----LSNFKHAAVGGKFRSAMDTAVVSYLR 403
62 -49.700[R] KOG4227 WD40 repeat protein  ali follow..  15  5.......................................................................................................................................................................................................................................................................................................................................................................................................AGLGGSMRSVVGFLSQRGLHGDPLLTQDFQRRRLRGCRNLY-------KKDLLGHFGCVNAIEFSNNGQWLVSGGDDRRVLLWHMEQAIHSRV-EHHSNIFCLAFNSGNTK-VFSGGNDEQVILHDVESSETL------------------------------------------DVFAHEDAVYGLSVSPVNDIFASSSDDGRVLIWDI-RESPHGEPFCLANYPSAFHSVMFNPVEPRLLATAKEGVGLWDIRKPQLRYGGNLSLQSAMSVRFNSNGTQLLALRRRLPPVLYDIHSRLPVFQQGYFNSCTMKSCCFAGDRDYILSGSDDFNLYMWRIPADPEAIGRVVNGAFMVLKGHRSI----VNQVRFNPHTYMICSSGVEKIIKIWS 361
63 -49.400[DO] KOG0305 Anaphase promoting complex, Cdc20, Cdh1, and Ama1 subunits  ali follow..  32..........................................................................................................................................................................................................................................................................................................................................................RSAKDFDFANYALTQGSKRNLDEVTSASRKAYMTQLAVVMNQNRTRILAFRNKPKSLLSTNHSDSPHQNPKPVKPRRYIPQNSERVLDAP------GLRDDFSLNLLDWGSANVLAIAL--GDTVYLWDASSGSTSELVEDKGPVTSINWTQDGL-DLAVGLDNSEVQLWDCVSNRQVRTLRGGHESRVGSLAWDNHILTTGGMDGKIVNNDVRIRSSVETYLGHTEEVCGLKWSESGNKQASGGNDNVVHIWDRSLKQTRQWLHRFEEHTAAVRALAWCPFQASLLATGDGKIKFWNTHTGACLNSVETGSQ-VCSLLWSQSERELLSGFTQNQLTLWKYP-SMSKMAELNGHTSRVLFMAQSPNGCTVASAAGDENLRLWNVFGEP----------PKTTKKAASK----KYPELFSHVNS............... 442
64 -49.300[R] KOG0646 WD40 repeat protein  ali follow..  11  2.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................EITVIASSSIDEGIGSWDLKTGTEQLQFPCASPAHGLTAVGEKSSQLSARNTSGSIFYWSWTKPQAEVKSYPVEPIKALAANNEGTYLVGGGISGDIYLWEVATGKLLKKWHGHYRSVTCLVFSGDDSLLVSGSQDGSIRVWSL-QQGNTLYEHNFNEHTMSVTDIVIDYGGCIISSSEDRTCKVWSLSRGKLLKNI-IFPSVINALALDPGGCVFYAGARDSKIYIGAINAGTQVLGSVSEKGKAITCLAYCADGNLLISGSEDGVVCVWDPKSLR---------HVRTLIHAKGSRKGPVNNI---QIVRKTIVANSNKTQVSWK 334
65 -49.000[I] KOG0301 Phospholipase A2-activating protein (contains WD40 repeats)  ali follow..  12  1...........................................................................................................................................................................................................................................................................................................................................................................................................................MADDGLGDVPMETESMPQYTI-------SHVIEAHKSDTKALAVTQGGC-LISGGRDETVKFWAKKGKQYTKTHPKGITVNSIAYAELADGWRLFVGRRDGTI----------------------------------------AVFGPSQAEPYAIFNEHKQNVCCLHINEKATHMLSGSWDSNVIIWPITELNSSFTTIVCPGHTLSVWALASFPDLPYLSASADKTIRMWF--GDTTLSVFKGHTDVVRALVVLSSSH-FLSAGNDGHIIHWDVA-SASILRKFATQAHEF-IYSMTLSDSHILTTGEDGTLEFWAIDGGKDGNL--AIVSEAVIQLPTT----NTWDAKVLLNSD-IAVAGSDGRIYIMT 320
66 -49.000[A] KOG0299 U3 snoRNP-associated protein (contains WD40 repeats)  ali follow..  38.............................................................................................................................................................................................................................................................................................................................................................EDLASISSESEFNGFEDEIDEENEDTYETAAEKRLRLAREYLDEVKNELVEAKEVDRELLASRLKEDVLEKKGQMYLDYTSKIPDVKIETAQLRGRHMRPLVGVVAYENF--VYSADKSGLIQKWEALQEKDTENRNDDHEIGKAIKLHFRPI---------------KFSRSRRGENDHVKEITCLAISNDGRWIVTGGLDHRIVIRDSVTLEPQHCWKHHRDAVMGLAMRRGTNEMFSCSADRSIK---VWSLDQMSYIETLFGHQDVIFGVDALARERCVSVGGDRTSRLWKIVEESQLKATAGYMEGSVDCVAMIDEDHFVTGSDNGVIALWSVQRTSPDPVTIPPQPRWITSLAAIPYSNLFASGSWDGNIRLWKIAEGLRSFEPLTIATPLSVYG--------INSLSLSLQGKGFAACGRETRVGRW. 493
67 -48.400[R] COG2319 FOG: WD40 repeat  ali follow..  11  149...................................................................................................................................................................................................................................................................................................................................................................TQKCPTMVASEKDNKGKLNEKKNRSPENLLPFRILDAPELRDDFYTSLLSWSPKGDLAIGL--AENIYLWSKELGPTR--------VLEESIYDVSSVAYSYNGDILAVGRVDGTLQFWQDNERVPRISIHHPGDIGVLAWKPVLETNRLLVGKGNGNIFVYDIIWSESTSK---------------------------------AVLVATITNAHDEQVCGLTWNHDGSQFASGGNDNR---VCLFKGSDLRQPLYVWQQNAAVKALSFCPWQRSLLATGDKHIRFYNCFNGKKIDELYCGAQ-ITSIHWSPKYREFSVTTVQHRFAVYSWPQLECLVSLPSVPDIRCVHSVLTSQTDSIIIASSNETIKFFDLSEESSWHNSRV----------LTWHGIFDSQILEMLEG---IDGKIDSHLR... 535
68 -47.500[BL] KOG1009 Chromatin assembly complex 1 subunit B/CAC2 (contains WD40 repeats)  ali follow..  14  7.......................................................................................................................................................................................................................................................................................................................................................................................................EIAWHNKEPVYSLDFQHGTARLASAGVDTNVRIWKVEKGPDGKAIVEFLSNLARHTKAVNVVRFSPTGEILASGGDDAVILLWKVNDN---------KEPEQIAFQDEDEAQL-----------------------------------------------------NKENWTVVKTLRGHLEDVYDICWATDGNLMASASVDNT---AIIWDVSKGQKISIFNEHKSYVQGVTWDPLGQYVATLSDRVLRVYSIQKKRVAFNVSSMKSFFRRLSFTPDGSLLLTPAGCVESGENVMNTTKRPIAHLPCPGKATLAVRCCPYRLVFAVASED-SVLLYDTQQSFPF--------GYVSNIHYHT----LSDISWSSDGAFLAISSTDGYCSFVT 374
69 -46.800[S] KOG2110 Uncharacterized conserved protein, contains WD40 repeats  ali follow..  2...............................................................................................................................................................................................................................................................................................................................................................................................................HFFVRKYRGKAALLSIGTFDG-YKIYNCD-------PFGKCFHKIQGATSIVEMLFSTSLVALVEKDDGNNLKLINTKKSTTICELTFPTPLLAVKLNRKRLLAVLE----------------------EQIYVYDISNMLLLHTIETTSNVFAVCALSPNSENCYLAYPDSRDHEPRTEGESSSPNVSNSAVSGQVI---LWDVINCKQITKIEAHKDSLACLAFNSDGTMLATASDNGIRVFAIPSGQRLYQFRSLPAQIYSIAFHPDSSLLTVTSSTQTVHIFRLK-EVYSNLERQGLLPSSPPPKESLLRRSSRSLIGTVGGYLPQSVS-------GMLDPERDFAYAHIPGDKVTSIAAFGPDNTIVNVATYDGNLYSFR 351
70 -46.400[R] KOG0322 G-protein beta subunit-like protein GNB1L, contains WD repeats  ali follow..  12  1...............................................................................................................................................................................................................................................................................................................................................................................................................................................MAVLPPDPVFSLRSPDGAVNSLCFQESDR-LLAGTIKGSVFLWDLQTNRSALHFEGSDPITSLHHTPDR---LVTQEKGGTITMFSIGGSSYVKERSIP----------------------------------GNHLGFCRSALHTNTSKTNEQLLFYPCEESSIG---VLHVTDAAAPTQILVPDDPCFKPFECASQLFLLAGYSGHFLTWDISSSVIL-DVMELAQDATSVDYDPVTNRGIVGGPTDKLISFSYQRSSQLGSELCIKNPGVNGVRIRPDQKVFASAGWDGRIRIFSWKSLR---------PLAVLTQHK---NGGVMDLAFSSQAPIMAAAGMDGQISLWD 320
71 -46.200[A] KOG0647 mRNA export protein (contains WD40 repeats)  ali follow..  11  2...................................................................................................................................................................................................................................................................................................................................................................................................................SFFNRSNTTSALGTSTAMANEKDLAND---------IVINSPAEDSISDIAFSPQQDFMFSASSDGKVRIWDVQNGVPQGRAESSSPVLCTRWSNDGT-KVASGGCDNALKLYDIASGQ------------------------------------------TQQIGMHSAPIKVLRFPSNTECIVTGSWDKTIK---YWDMRQPQPVSTVMMPER-VYSMDNKQSLLVVATAERHAIINLANPTTIFKATTSPLKWQTRCVACYNEADGYAIGSVEGRCSIRYIDPNRAPGSNGQSLVYPVNSIAFHPLYGTFVTAGGDGTFNFWDKNQRHR---------LKGYPTLQ----ASIPVCSFNRNGSVFAYALSYDWHQGHM 339
72 -46.200[R] KOG2919 Guanine nucleotide-binding protein  ali follow..  10  85......................................................................................................................................................................................................................................................................................................................................................................................................TSNGNEAKPEDQELAIAPVLQYFQGALVELGRRCWTSS---------------TEAQHYTKGCYWSPDGTCLLVPVHLDGMHVIEMPSDQSEVHVPEGGTVYDCVWYPHMN-----------------------------------SLQPETCLWLATRQHEPIHMWDAFDGSLRCSYSGYDMAAISLAFSHDGEQIYAGYKR----CIKIFDTSRPGRFCDDYPVKFAISCIAQTTAHPHTLTCGHGYIQHFDLRCSHPLFTLGGHKGGITQLRYGEFGNGFSGARKCDKILQWDMRNYKQPLVELQRHVDTNQRIQFDSDSNWLASGDTRGFVNVWDLKKYG---------DPSVLPLHSDC----CNGVALNPAMPILATSSGENAVVMWW 482
73 -45.700[R] KOG1310 WD40 repeat protein  ali follow..  12  1......................................................................................................................................................................................................................................................................................................................................................................................................MDNLSFHDGNIFNLLHTRSQDPSHEVDQRMQFHSSLVRRLSQE-------QELEGHQGCVNALAWNSNGSLLISGSDDLRINIWNYSSRKLLHSIGHTANIFCTKFVPETSDELVVSGAGDAEVRLFNTSRLSGRAEDDNA------------------------------IIPSALYQCHTRRVKKLAVEPGNPVVWSASEDGTLRQHDFRESTSCPPLADPPKQTLSLKSCDISATRPLLVGGSDAFARLYDRRMLPPLSERGRTNLHLTHVTFSPNGEEVLLSYSGEHVYLMNVEGAIDMKRRYVGHCNVGTDIKLGQRGEYIASGSDDGRWFIWEKQTGR----------MKVLVGDES-----LNCIQCHPFDSVVATSGIDNTIKIWS 688
74 -45.400[S] KOG0294 WD40 repeat-containing protein  ali follow..  2.......................................................................................................................................................................................................................................................................................................................................................................................................................PPEMEIIEATNEELLLGFKLIKSPTDSVKFELKQTFADSSYARSITSLAVQWPWVASGGTDGRIFVYDMRTRKQSQIISHAGRVNTLKFTPDLSL-LLSGSDDGHMIATRVGSWTKEY----------------------------------------DWQKAHAGAVTHVSCHPSSKLALSLGGDQVLN---TWNLVNGCVAHKTNTLDFQTGCLSWSKQGDHFTLSGPLVLEIWGIENAHVMRRIE-MPSKPICITWL-DGNECLTGLDNGNIAWISLKDEDTPPTFILAHEVRVKAIAY--LNEFLATVSIAGQIKVWKIDMETRKLEE------------RSFMDCRPTDLGLLDLRQFGNVRPVEQRTKVEE 332
75 -45.100[R] KOG2444 WD40 repeat protein  ali follow..  12  1........................................................................................................................................................................................................................................................................................................................................................................................................MLVEFDNPPLCMKSNKDGSRLVVGFVDGSIRFYDTQQHE----EEFQEIWKFQTKSSIRGVDLDEHKKRVYAVTKNRSLCVFDIDTGKRVRCI----------------------------------------------------------------------------------LKCHRSVPTAICTLPKSQQLATADESGEVKTWNL-VASENANIRKWQEQDEDINDLKVDVKSNLLATSSDGTLGAYDLRKAKLKMRSELMHSEL--YSVCGTNRSVYVGGEDGYVEVFNLNEYGNLLRVESGFEMGVNGIVELRSGLLGLTSQGSNRMRLLNVQPSK----------LGYAGYHGDSDDDGIDAITISTDKSTVFMISMSCTIKKWD 305

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Sasin JM, Godzik A, Bujnicki JM. SURF'S UP! - protein classification by surface comparisons. J Biosci. 2007 Jan;32(1):97-100.