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Query: [T] KOG0705 GTPase-activating protein Centaurin gamma (contains Ras-like GTPase, PH and ankyrin repeat domains), from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MGNILTCRVHPSVSLEFDQQQGSVCPSESEIYEAGAEDRMAGAPMAAAVQPAEVTVEVGEDLHMHQVRDREMPEALEFNPSANPEASTIFQRNSQTDVVEIRRSNCTNHVSTVRFSQQYSLCSTIFLDDSTAIQHYLTMTIISVTLEIPHHITQRDADRSLSIPDEQLHSFAVSTVHIMKKRNGGGSLNNYSSSIPPTPSTSQEDPQFSVPPTANTPTPVCKRSMRWSNLFTSEKGSDPDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWLKTWKKKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDLQTSTIKVPGKWPSLATSACAPISSSKSNGLSKDMDIGLGDSICFSPSISSTTSPKLNPPPSPHANKKKHLKKKSTNNFMIVSATGQTWHFEATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTSQSEAMALQSIQNMRGNAHCVDCETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELDDWPVELRKVMSSIGNDLANSIWEGSSQGQTKPSEKSTREEKERWIRSKYEEKLFLAPLPCTELSLGQQLLRATADEDLQTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQYGCPDECVLast
1 -155.000[T] KOG0705 GTPase-activating protein Centaurin gamma (contains Ras-like GTPase, PH and ankyrin repeat domains)  ali  100  1MGNILTCRVHPSVSLEFDQQQGSVCPSESEIYEAGAEDRMAGAPMAAAVQPAEVTVEVGEDLHMHQVRDREMPEALEFNPSANPEASTIFQRNSQTDVVEIRRSNCTNHVSTVRFSQQYSLCSTIFLDDSTAIQHYLTMTIISVTLEIPHHITQRDADRSLSIPDEQLHSFAVSTVHIMKKRNGGGSLNNYSSSIPPTPSTSQEDPQFSVPPTANTPTPVCKRSMRWSNLFTSEKGSDPDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWLKTWKKKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDLQTSTIKVPGKWPSLATSACAPISSSKSNGLSKDMDIGLGDSICFSPSISSTTSPKLNPPPSPHANKKKHLKKKSTNNFMIVSATGQTWHFEATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTSQSEAMALQSIQNMRGNAHCVDCETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELDDWPVELRKVMSSIGNDLANSIWEGSSQGQTKPSEKSTREEKERWIRSKYEEKLFLAPLPCTELSLGQQLLRATADEDLQTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQYGCPDECV 663
2 -78.200[T] KOG0818 GTPase-activating proteins of the GIT family  ali follow..  33  2..............................................................................................................................................................................................................................................................................................................................................................................................................................................................SKRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTLLQMVETLYNNGANSIWEHSLLDRKANPQDKVHPNKAEFIRAKYQMLAFVHRLPCRAKDLSKQLHSSVRTGNLETCLRLLSLGAQANF---FHPEKGNTPLHVASKAGQILQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVEIQYELT.. 227
3 -76.900[T] KOG0521 Putative GTPase activating proteins (GAPs)  ali follow..  18  1MRATIEFEECLKDSPRFRQF-EKIIKLCNVAVDSGKEYVKNQSAFAMSLWDLQQHFLDNKNHCFQEMNKFHTILLDQASRTVLKNLSVFVKDDINQVKDYKGLKVSEGYDNALIKNAQASKNRPQEMQEAANILSASKSCFQHTALDYVNYITLAQARKVPSILSTLLDYYQACVTYYHQGFDLCNDFDEFFKNISEDLNALRGDYQQLEKAM---------------------------QNRHMSVNRYCDSNTNSTSNKIEGYLFKKKSKGFKTWCRRWFYLSDNQLVYRKRSNED---SFSVMEEDLRICSVR--------------------------------------------------------------PVNEGDRRFCFEVISPTKSHILQADSADMLSLWISALQHSIGAAIQHDSTHHSRPQSTNAKRRIHWEEFLKIPGNAYCCDCRSPEPRWASINLGITLCIECSGVHRSLGVHYSKVRSLTLDAWESENVKVMMELGNEVVNRIYEARIGDDKKPTEQCEIGVREAWIKAKYVERRFVCGMPKSQLDANQLLYMASVVHNLPVMCMAFALGADKMW--KNPQDRQRSFLHQAVISGSVMACEFLLLNGAAIDAVDEMGYSALHISTAKGHIAQVYLLLKHKAAYDL. 744
4 -56.900[T] KOG0703 Predicted GTPase-activating protein  ali follow..  40  2..........................................................................................................................................................................................................................................................................................................................................................................................................................................NEKANVSKELNARHRKILEGLLKHPENRECADCKTKGPRWASVNLGIFICMQCSGIHRSLGVHISKVRSATLDTWLPEQVAFIQSMGNDKANSYWEAELP------PNYDRVGIENFIRAKYEEKRWVSR........................................................................................................... 125
5 -45.900[TUZ] KOG0704 ADP-ribosylation factor GTPase activator  ali follow..  32  1..................................................................................................................................................................................................................................................................................................................................................................................................................................................MASPRTRRVLKELRPCDDNNFCFECEANNPQWVSVSYGIWICLECSGIHRSLGVHLSFVRSVTMDKWKDIELAKMKAGGNRKFAEFLQSQ-----------PDYKEKWTIQEKYNSRAAA............................................................................................................. 109
6 -45.300[U] COG5347 GTPase-activating protein that regulates ARFs (ADP-ribosylation factors), involved in ARF-mediated vesicular transport  ali follow..  30  2........................................................................................................................................................................................................................................................................................................................................................................................................................................................SYKLDQLTRLPENKKCFDCDAPNPQWASCNLGIFICLDCSGQHRGLGVEKSFVRSITMDNWSERQVKMMEVGGNSNAKTFLSTDPMFSAAGSIREKYNTDRQKIRAEVDGVEWVKV........................................................................................................... 122
7 -40.700[T] KOG0706 Predicted GTPase-activating protein  ali follow..  34  2................................................................................................................................................................................................................................................................................................................................................................................................................................................GDPSKQDILTIFKRLRSVPTNKVCFDCGAKNPSWASITYGVFLCIDCSGSHRSLGVHLSFIRSTELDSWSWFQLRCMQVGGNASASSFFHQH---------------STNDTNAKYNSRA............................................................................................................... 109
8 -18.400[I] KOG0817 Acyl-CoA-binding protein  ali follow..  12  12.............................................................................................................................................................................................................................................................................................................................................................................................................................TGDSGGELSSGDDSGEVEFPHSPEIEETSCLAELFEKAAAHLQGLIQVASRE-----------LYLYARYKQVKVGNCNTPKPSFDFEGKQKWEAWKALGDSSPSQAMQEYIAVVKKLDPGWNPQIPEKKGKEANTGFG--LYHEETIREEDKNIFDYCRENNIDHITKAIKSNVDVNVK----DEEGRALLHWACDRGHKELVTVLLQHRADINCQDNEGQTALHYASACEFLDIVELLLQSGADPTL. 253
9 -17.200[R] KOG2384 Major histocompatibility complex protein BAT4, contains G-patch and ankyrin domains  ali follow..  17  8..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................HPNWLALTTL----------------PLQLKRFVRAGD-PKAVKHQIDGLNGAEAREFYKEVLD--APTTCQPNLPSTHKTAQTRREPERILVPFDKSK------FFRLATSNKVEELSQMKASEEDLNSR----DSFGWTALMMAACEGATEAVSWLVQRGVQVETSDKSGNTALKLAQRKGHLDVVHLLESLPILEET. 185
10 -17.100[R] KOG0508 Ankyrin repeat protein  ali follow..  14  14...............................................................................................................................................................................................................................................................................................................................................................................................................WIIHWEQQQTEMKLVFKNIPYKPAQTKIFQGVRLNFAGVKSPCVHETLQVLFQQL--GEIPNTSQEVISVR-GLHPCMALRE-SFLSNPSSPPLSSLDCHKQGLTQGLLLLLCGLEPVGLVPVAPPGQLSTAGGRRGDAAAHRRLLGPVRRERGGRWLGALRWRDRGGCAAAVGADHLDVVRSLLRRGASVNRTTRTNNRHGHTCLMISCYKGHREIARYLLEQGAQVNWRSAKGNTALHNCAETSSLEILQLLLGVTGHTNIV 331
11 -16.700[E] KOG0503 Asparaginase  ali follow..  14  418................................................................................................................................................................................................................................................................................................................................................................................................................DYDLVDAVARSLHLSSPQELDQLGETLFPAMINAAVAEGDPKKINNLKAYGADLSGTNHDQRTALHLACQLGNVEIVK------QNGVSVH-----VRDRYDRTPLLEAVATDSEIIQLLINCGAH------------------------------LTGSSRAVGEQLCAAAARGSMIRLKSYQYAGADLAQS----DPSGRTALHVAALHGFPEVVQYVLPYFENPNEKDMLGLTAMDYAERGGHAAVMEVLKS........ 631
12 -16.400[O] KOG4412 26S proteasome regulatory complex, subunit PSMD10  ali follow..  17  1.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................MEIATD-----TAKQMRDEELFKAAEWGDSLFMSLSEEQLSKSLNFRNEAASFGHSQIVKLLSSSDEAKTVINSKDDEGWAPLHSAASIGNAELVEVLLTRGADVNAK----NNGGRTALHYAASKGRLEIAQLLLTHGAKINITDKVGCTPLHRAASVGKLEVCEFLIEEGAEIDA. 177
13 -16.100[R] KOG0509 Ankyrin repeat and DHHC-type Zn-finger domain containing proteins  ali follow..  14  23.................................................................................................................................................................................................................................................................................................................................................................................................................GRYGICAHENKELANAREALPLIEDSSNCDIVKATQYGIFERCKELVEAGYDVRQPDKENVSLHWAAINVRFYI---------SKGAVVDQLGG----DLNSTPLHWAIRQGHL---PMVILLLQHGADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSVNTPLMLSAHKVIGPEPTGFLLKNPSLNV---VDKIHQNTPLHWAVAAGNVNAVDKLLEAGSSLDIQNVKGETPLDMALQNKNQLIIHMLKTEAKMRA.. 277
14 -15.600[E] KOG1709 Guanidinoacetate methyltransferase and related proteins  ali follow..  27  5.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................DQLCLAAKSGDLKKVQTLIYSGADVTHF----DNDGLTPLMHAAKIGNAEIVTALLESGAPWNALSPSNLSAGDFAMEAGHQETFDLLLKTGIQSELI 98
15 -15.300[OT] KOG0505 Myosin phosphatase, regulatory subunit  ali follow..  22  4.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LEHLGGKRAESARAEQLRRWRGTEQEPAERRG-------------------AGRQPLTRRGSPRVRFED--------------GAVFLAACSSGDTDEVRKLLARGADINT----VNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEGWTPLHAAASCGYLNIAEYFINHGASVGIV 153
16 -14.400[R] KOG0514 Ankyrin repeat protein  ali follow..  16  223.................................................................................................................................................................................................................................................................................................................................................................................................................ALTERELKVAYTTVLQEWLRLACRSDAHPELVRRHLVTFRAMSARLLDYVVN--IADSNGNTALHYSVSHANFPVVQ-------LDSGVCKVDKQNRAGYSPIMLTALATLKTQDDIETVLQLFRLGNINAKASQAGQ--------------------------TALMLAVSHGRVDVVKALLACEADVNV----QDDDGSTALMCACEHGHKEIAGLLLVPSCDISLTDRDGSTALMVALDAGQSEIASMLYSRNIKCSV. 448
17 -14.400[T] KOG4335 FERM domain-containing protein KRIT1  ali follow..  13  1.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................MGLEIK-SKMLALEKADTCIY-----------NPLGGSDLQYTNRVDNPYFGLGAPDYSKIQIPKQEKWQRSMSSVTEDKERLHRSACEGDSELLSRLLSERFSVNQL----DSDHWAPIHYACWYGKVEATRILLEKGCNPNLLNGQLSSPLHFAAGGGHAEIVQILLNHP...... 171
18 -13.400[R] COG0666 FOG: Ankyrin repeat  ali follow..  471...............................................................................................................................................................................................................................................................................................................................................................................................................LSAKNSTSSHVLYHVMANGDADMLKIVLDALSLLIRTCHLTKEQVLDLLKAKDFY-----GCP---------GLYLAMQ-NGHSDIVKVILEALPSLAQEI-ASDIVDLLTAKSLARDTGLFMAMQRGHMNVINTIFNALPTLFNTFKFDKKNMKPLLLANNSNEYPGLFSAIQHKQQNVVEMVYLALSDHARLFQHKAPQKYSAFELACELGHRVIAELIFNTLNKMAESFGFTDNPRYIAEKNYMEALLKKASPHTVR.... 728
19 -13.300[R] KOG1710 MYND Zn-finger and ankyrin repeat protein  ali follow..  24  1............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................MTTTEEAPKSPLFEAIDKNDTEAALALLKTKEQAAQR----DPSGMSVLAAAAYRGNLTLVEKAIELKCDVNDKDGTLYTPLMFAALSGKQDVCRLLMDSGARMYLV 104
20 -12.800[R] KOG0522 Ankyrin repeat protein  ali follow..  22  16.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................VHHAVVTRDYAGLKKLLSALPKMRDPSEVQNENRDTALHLAVKLGDETSAEMLMAAGADWSLQNEHGWSALQEAICGREERIAMIIVRHYQPLAW. 133
21 -12.500[R] KOG2505 Ankyrin repeat protein  ali follow..  216...............................................................................................................................................................................................................................................................................................................................................................................................................ASNEFNPRDPHVPKVLAQKTIHRYRKQGGSQGAADNTKGNIHSAGSGLRRYNEQALIKDIQQVFKDWGKLETCDLIFVRAIGSSNRISPKDPKLRVFPFTTKRATHSEL-LRCYKELVTPKISHVDSISIKAQEEERKRQAEIEKEIRQSRLQEEERKKKKLAKYTEVIISNLKASNIEAFLEYLRS-INFQFYPKNVHLHTSTPLHYAVTQKNAKLVAKLLRNGADPAMLNGNGKTPFEISTGNKEVKDEFLIARHELGES.. 493
22 -11.900[TV] KOG1739 Serine/threonine protein kinase GPBP  ali follow..  18  3..............................................................................................................................................................................................................................................DNQSWNSSGSEEDPETESGPPVERCGVLSK--TNYIHGWQDRWVVL-KNNALSYYKSEDETEYGCRGS-ICLSKAVITP----------------------------------------------------------------HDFDECRFDISVNDSVWYLRAQDPDHRQQWIDAIEQHKTESGYGSESSLRRHGSMVSLVSG............................................................................................................................................................................................................................. 139
23 -11.900[R] KOG1595 CCCH-type Zn-finger protein  ali follow..  21  3...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................GAKSNLCSSKTLTEVEFMR------QKSEDGASATCLLEFAACDDLSSFKREIEENPSVEIDESKMGFEERTPLMVAAMYGSMEVLNYIIATGSDVNRVSDEKVTALHCAVSGCSVEIIKILLDASASPNCV 144
24 -11.200[PT] KOG3676 Ca2+-permeable cation channel OSM-9 and related channels (OTRPC family)  ali follow..  25.......................................................................................................................................................................................................................................................................................................................................................................................LDGDPNSRPPPAKPQLSTAKSRTRLFGKGDSEEAFPVDCPHEEGELDSCPTITVSPVITIQRPGDGSTGARLLSQD-----SVAASTEKTLRLYDRRSIFEAVAQNNCQDLESLLLFLQKSK-PETGKTCLLKAMLNLHDGQNTTIPLLLE-------ARQTDSLKELVNASYTDSYY-----------QTALHIAIERRNMALVTLLVENGADVQAAAHGDFYFGELPLSLAACTNQLGIVKFLLQNSADISARDSVGNTVLHALVEVADNTADNTKFVTSMYNEIL 314
25 -11.000[T] KOG2209 Oxysterol-binding protein  ali follow..  28  2................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................NTEAEQQLLHHARNGNAEEVRQLLETMARNEVIADINSNLGWTPLHLACYFGHRQVVQDLLKAGAEVNVLNDMGDTPLHRAAFTGRKELVMLLLEYNADTTI. 109
26 -10.800[R] KOG0511 Ankyrin repeat protein  ali follow..  26  6.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................MDKNFEELCYSCRTGDMDNVDRLISTGVNVNSVDKFDNSPLFLASLCGHEAVVKLLLQRGAVCDR. 70
27 -9.640[T] KOG3723 PH domain protein Melted  ali follow..  21  709..............................................................................................................................................................................................................................................................EGGAEKVLEGQLKEKKGRWRKRWNTKYFTL-SSAALNYSTQHMPTDSRALLPSIDLRSISVRSLGRGKKA--------------------------------------------------------RKSLRKAFEIFTADNTSMILKAKDEKNAEEWLHCLQIAMAHARRELA............................................................................................................................................................................................................................................ 827
28 -9.590[K] COG5641 GATA Zn-finger-containing transcription factor  ali follow..  23  91...............................................................................................................................................................................................................................................................................................................................................................................................................................MSPDTNSLHHILPKNQVKNNGQTMDANCNNNVSNDANVPVCKNCLTSTPLWRRDEHGAMLCNAC-GLFLKLGKP----RPISL-----------------------------------------KTDVIKSR.................................................................................................................... 178

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Li W, Godzik A. cd-hit: a fast program for clustering and comparing large sets of protein or nucleotide sequences. Bioinformatics. 2006 May 26;