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Query: [S] KOG0772 Uncharacterized conserved protein, contains WD40 repeat, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MDDNTAPKKNSEKKARVFDLQAMFAQTISNAPRTEEPTHVPQSVSVSSKSESGVSSSAVSDDEDDFMPDLPPGFQMQQSEAGPSSSRAEGPEDSDDSDFDETEAISIIKLIPAACEAKISHGTQAISALRVEPPGVRFASGGLDYYVKLFDFQKMDMSMRYDKELLPAESHVINSLAFSPNGETLVVASGEAIIRLLDRAGKQWSETVRGDQYIIDLNITKGHTATVNCVEFNPLNKNEFISCSDDGSLRLWNLDDHKVITKCINKHRKVIKTKGANGKRVSPQVCTFSPDGKWIAAGCDDGSVQAWKYGSQYVNVNYLVRKAHNGSITSIAFSPDSKRLLSRGFDDTLKMWSLDNPKEPLLVKTGLENAFKSTDCGFSPRAEVVFTGTSSPNKDTPGTLQFFDPMTFDLVYKIDYPGISCHRIQWHPRLNQIIAGLSDGTIHVYYDQTMSQRGVMSCVTKPLKRNRASEVVREDMVLSPLSLEMFQPRGEEGEEKEVTGWRIKKYLRMQDNKLRPEFRKPADMPINGKSANGRVAASGGSLHSYLAKQIGTARNAEFLKDTDVRASILKHAKDAEENPLYIDKAYRKTQPKKIFQETAVEPEDQDDEELQPVFKMPRTKLast
1 -133.000[S] KOG0772 Uncharacterized conserved protein, contains WD40 repeat  ali  100  1MDDNTAPKKNSEKKARVFDLQAMFAQTISNAPRTEEPTHVPQSVSVSSKSESGVSSSAVSDDEDDFMPDLPPGFQMQQSEAGPSSSRAEGPEDSDDSDFDETEAISIIKLIPAACEAKISHGTQAISALRVEPPGVRFASGGLDYYVKLFDFQKMDMSMRYDKELLPAESHVINSLAFSPNGETLVVASGEAIIRLLDRAGKQWSETVRGDQYIIDLNITKGHTATVNCVEFNPLNKNEFISCSDDGSLRLWNLDDHKVITKCINKHRKVIKTKGANGKRVSPQVCTFSPDGKWIAAGCDDGSVQAWKYGSQYVNVNYLVRKAHNGSITSIAFSPDSKRLLSRGFDDTLKMWSLDNPKEPLLVKTGLENAFKSTDCGFSPRAEVVFTGTSSPNKDTPGTLQFFDPMTFDLVYKIDYPGISCHRIQWHPRLNQIIAGLSDGTIHVYYDQTMSQRGVMSCVTKPLKRNRASEVVREDMVLSPLSLEMFQPRGEEGEEKEVTGWRIKKYLRMQDNKLRPEFRKPADMPINGKSANGRVAASGGSLHSYLAKQIGTARNAEFLKDTDVRASILKHAKDAEENPLYIDKAYRKTQPKKIFQETAVEPEDQDDEELQPVFKMPRTK 620
2 -77.300[A] KOG0306 WD40-repeat-containing subunit of the 18S rRNA processing complex  ali follow..  12  34.EKGRYVAVPACEHVFIWDLR--------KGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEVTFNGHKAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFLREKNLLVTSGKDTMVKWWDLDTQHCF-----KTMVGHRTEVWGLVLLSEEKRLITGASDSELRVWDIAYLQEIEDPEEPSCRKAGSIMREGRDRVVNLAVDKTGR-ILACHGTDSVLELFCILSKKEIQKKMDKKMKKARKKIKTSAKIKSFDLIHSPHGELAVFLLQNNLVELYSLNPSLPTPQRITIGGHRSDVRTLSFSSDNIAVLSAAAD-SIKIWNRSTLQCIRTM-----TCEYALCSFFVPGDRQVVIGT------KTGKLQLYDLASGNLLETIDAHDGALWSMSLSPDQRGFVTGGADKSVKFWDFELVKDENSTLQLDEDVLCVSYSPNQSLYGHKLPVICMDISHDGALIATGSADRNVKIWGLDFG-DCHKSLFAHDDSVMYLQFVPKSHLFFTAGKDHKIKQWDADKFEHIQTLEGHSPSGDYVVSSSHDKSLRLWERTREPEEEREMEREAEYEESVAKEDQPAVPGET..... 739
3 -76.200[A] KOG0291 WD40-repeat-containing subunit of the 18S rRNA processing complex  ali follow..  13  25.DGNSVISPVGN-RITVYDL--------KNNKSRTLSLESRYNYTNIALSPDGSLLIAVNEKGEAQLISMMSCTVIHRKFQTGVQCICFSPNGAFFAVAVQNVVLIFCAYNPFVLRRRFLGGFDDVTWLDWSSDSRLLAIGCRDSSTKIVAINYTK---NFRTYNLSGHTDAIVACFFEANSLHLNTISRNGQLCLWECSLAPSDLEDAERPKIAPPPRKEQRDVQLTAANYNTRTK-VLVVAFSSGAFYLYELPDVNMIHSLSISDYPISAALKQQGHSSEMTCIAYSSDGQFIATGGEDSKVKLWNTQSSFC---FVTFSEHTSGVTGIQFSRNKKFLVSSSLDGTVRAFDVNRYRNFRTFTS--PNPAQFSCVAVDYSGELVVAGGQ-----DVFDIFLWSVKTGKLLEIISGHEGPVVSIAFSPTSSTLVSGSWDKTVKIWNCLESNSEHETIDAVSDVTNVTFSPSGEEIAVATSGNITIFDIKSAGQVTTIEGRNDLSAGRLETDIITARKNAQANYFSTIEYSADGECILAAGKSANICIYHVREAILLKKFEITSEFGNMALVEGGRVAIRLPGVQRGDMSS.............................. 719
4 -74.300[A] KOG0319 WD40-repeat-containing subunit of the 18S rRNA processing complex  ali follow..  11  120.EGHLLATGSADHIVKVWNLTEQQ-MRGAPKKLVNTWKSHNSHITALLQVPDSRVVVALSRDQTMSIHETETQETLRVPLYESIEGGAIGHNGN-LFTVGEEGVVKEFVIETAKLVRKKRIASSNLDHLAYDVVSNRFLAISAEQNLIILDFENLKIA----RQIVGFHDEIYSCCLLGKDESHMAVASNTSEIRLYNTKTLDCQLIRGHTESVVPVAAATGHANTVTALAISNTGRAFLASVSTDCTIKLWGLGVSTKLKEVKIDAEKLTCSSTMVAHGKDVNCVDISESDALIATGGMDKLVKLWQVDTHKMQLGIATLSGHRRGVGDVKFAKNSHKLASCSGDMTIKIWNISEKS---CLQTISGHSCAVFRVIFARNDSQLISA------DSAGIIKIWTIKTADCECSIDAHTDKIWSLSKNHNESEFVTAGTDGRIVVWKDVTEEKQKAEDNKRR--------------------EAIEQDQTLTNLLSQKRYSEALVFALTLAKP-FCAFKVINALMAEETPEELGSAIRRLDTRQIEILLQFTVKWNTNSRTSS-DPEELVSMPGAYGYIESFLPYTQRHMD.............................. 770
5 -73.700[Z] KOG0318 WD40 repeat stress protein/actin interacting protein  ali follow..  12  34.KGKNFLYTN-GNSVIIRNIE--------NPAIADVYTEHSCAVNVAKYSPSGFYIASGDASGKIRIWDTVNKEHLLQPIAGPIKDISWSPDNQRIVAVGEGREGHVFMSETGTSVGEISGQSKSINSADFRPARPRIVTGSEDNTIAVFEGPPFKFK-----MTKQDHSRFVQAVRYSPDGKFFASAGFDGKVFLYDGTSSELVGEFG----------SPAHKGGVYALAWKPDSTQ-LLTCSGDKTCRLWTVESRELVSEF------------VMGTTVDDQQVSCLWQGDNLITVSLSGVITYLNVADP--SKPLRVVKGHNKPITVLGLSDDRSTIYTGSHDGVVTNWNSGSGTNDRIT----GTGHGNQINGIAAWGDFVYTC------GIDDSLRQFSVEGNSYTDYVVKLNCQPRGLAILRNENIIALACIKELTLVQDQKKIFSLP----IKYEASSIAVNADTSDVAVGGAVTDVSYSPDLKYLVACDAHRKVVLYSVEEYKPHNKEWGFHSARVNTVAWSPNSLLVASGSLDTTIIIWSVANPAKHTIIKNAWLDNNTVISTGQDCNTKVWHVEN................................... 607
6 -70.500[S] KOG0271 Notchless-like WD40 repeat-containing protein  ali follow..  13  15.DENELGGSGILVPVDISTNEL-------QILCNQLLGSSDDPVPISFFTTEGAEIVDSIRKSLEEIDFETTLKASIPGHGEPVISAQFSPDGRGLASGSGDQTMRIWDIELELPLHTCKSHKSWVLCIAWSPDATKIASACKNGEICIWNAKTGEQIGK----TLKRHKQWITSLAWQPTCRLLASCGKDGNIFIWDTVQGTV------------VRCLSGHTASVTCLRWGGEGL--IYSGSQDRTVKMWRADDGVMC-------------RNMTGHAHWINTLALNTDYALRTSCFEPSKRCIKPDTVEECQKVA------QTRYEAALEIAGGERLVSGSDDFTLFMWNPKETKQS--INRMTGHMQLVNQVVFSPDTRYIASA------SFDKSVKLWCGRTGKYLASLRGHVGPVYQVAWSADSRLLVSGSADSTLKVFELKTKSLYYDL-------------------------------------------------------------PGHGDEVFTVDWSPEGTKVVSGGKDKVLKLWR....................................................................... 472
7 -70.000[R] KOG1539 WD repeat protein  ali follow..  12  108VFGEHVLSLDVEGNMFIWAFKGI--EEHLAPIGNLQLTGKFTPTSIVHPDTYLNKVLVGSQEGPLQLWNINTKKMLFKGWGSSVTSCVSSPALDVVAIGCADGKIHVHNIKLDEEIVTFEASRGAVTALSFSTDGRLLASGGSFGVISIWNLNKKRLQ----SVIRDAHDSSIISLNFLANEPVLMSASADNSLKMWIFDT--------NDGDPRLLRFRSGHSAPPLCIRFYSNGR-HILSAGQDRAFRLFSVIQEQQSRELSQRHISRRAKKSRNHLLLAILACAISACGNFAVVGTAGGWIERFNLQSGISRGSYKRRYAHDGEVIGVACDSTNTLMISAGYHGDLKVWDFKKRE----LKSQWDVGCSLVKIVYHRVNGLLATVA------DDFVIRLYDVVTLKMVREFRGHTDRITDLCFSEDGKWVISSSMDGSLRIWDVILAKQIDGV-------------------HVDVPITALSLSPNMDVLATAHSDQNGVY-QSMFSGLPSVESYASGKDVVNVKLPSVSALTSSEADDDMDRQVLENSEALQASSFSILPKSQWQSLINLD-IIKARNKPIEPPKKPEKAILFKANDSEADGENEENNKKDQNSMK 789
8 -69.700[BK] KOG1063 RNA polymerase II elongator complex, subunit ELP2, WD repeat superfamily  ali follow..  12  30.SG--LVSFGAQNAVAVFCPK--------TAQILTTLPGHKASVNCTHWLPTSKYLLSGDSDGIIILWELSTLNQLPLSHKKGVTCIMVSETDAMFASASSDGVVNVWDVSFPSCLDSICVDTKAIVTLSLNPGRFALALGGLDNKIKLYSGERTGKFTSV--CELKGHTDWIRSLDFSLPLHMLVSSSQDKVIRIWKLVLGPVFVSGTFTYQISVESVLIGHEDWVYSVEWQPPVIDSILSASMDKTMMIWRPEKKTGV-------VNVVCVGELSHCALGFYGGHWSPNSLSILAHGYGGAFHLWRNVSSSKESEQKVPSGHFAAVTDVTWARTGEYLLSVSQDQTTRVFSAWKNDHELARPQVHGHDINCVAMVQGKGNHRFVSGA------EEKVVRVFEAPLSSEPLERNGGGEGLDTFETVPEAAPAELKEPPIEDQLAFHTLWPESHKLYGHGNELFSLCSDHKGNLQSHSLTVTHLEFSYDDTLLLSVSRDRHFSVFSIQRTDKLMAKVEAHKRIIWACSWNPFGHQFATSSRDKTVKIWSVENDARIKQILDRNEKSGCVAVGMESGLIELSNVKIIETEE.............................. 782
9 -69.600[S] KOG0308 Conserved WD40 repeat-containing protein  ali follow..  10  1.....MSSCVNTSQTGPKK-------KISFIIRDEHEYSNRSAVSALQYDAQNGRLFTGGSDTIIRTWSVPHHKGSLEQHTDWVNDMILCGHGKILISASNDTTVKVWNIERDNFIDCIRTHKDYVSCLAYAPIVEKAVSASFDHNIFVYDINANFKTV----NNLIGCKDSIYSLATTPNLSLVLGAGTEKCIRLFDPRTNE------------KIMKLRGHTDNVRALVVNDDGTR-ALSAGSDATIRLWDIGQQRCI-------------ATCIAHEEGVWTLQVDSSFTTVYSAGKDKMVVKTPLYDFT---KSQLLFKEEAPVKKLLLSEKDNSLWVGTWKSDIKRWSIRPSAQ---LSIGGDEDGPSTSNANHSVSASSSPPVT------FKYIRVKDQKGQQSTELVIPGAPAIKKHAMLSDKRHVLTRDSDGNVALYDVLAARKIKDFEEVVDENSRQVYIPSWFVVDSKSGMLQITLDELDALSSWLSSKDAGFDDNDRETKQIIMMLRSLFERWPPCKMTNVDAADADDVQKATLNFISLPEHTPLIICEGNGDAGKEFEANELAQIAPMWVIDAIERNLPHPSTNPKQPKKDRLSATEMLQVKK..... 619
10 -67.700[B] KOG0639 Transducin-like enhancer of split protein (contains WD40 repeats)  ali follow..  13  371.PFGMVPHAGMNGELTSPGAA--------YASLHNMSPQMSAAAAAAAVVAYGRSPMVGFDPPPHMRVPTIPPNLAGIPGGKPAYSFHVTADGQMQPVPFPPDALIGPGIPRHARQINTLNHGEVVCAVTISNPTRHVYTGG-KGCVKVWDISHPGNKSPVSQLDCLNRDNYIRSCKLLPDGCTLIVGGEASTLSIWDLAAPT-----------RIKAELTSSAPACYALAISPDSK-VCFSCCSDGNIAVWDLHNQTLV-------------RQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQQH----DFTSQIFSLGYCPTGEWLAVGMESSNVEVLHVNKPDK----YQLHLHESCVLSLKFAYCGKWFVST------GKDNLLNAWRTPYGASI-FQSKESSSVLSCDISVDDKYIVTGSGDKKATVYE.............................................................................................................................................................................. 767
11 -67.600[D] KOG0642 Cell-cycle nuclear protein, contains WD-40 repeats  ali follow..  14  306.DGTDWEKEDQCLMPEAWNVDQGVITKLKSSRLPEHEINRADEVEALTFPPSSGKSFIMGADEALESELGP-------GELAGLTVANEADSLTYDIANNKDALRKTWNP-----KFTLRSHFDGIRALAFHPIEPVLITASEDHTLKMWNLQKTAPAKKSTSYTFRAHKGPVLCVVMSSNGEQCYSGGTDGLIQGWNTTNPNIDPYDSYDPSVL-RGPLLGHTDAVWGLAYSAAHQ-RLLSCSADGTLRLWNTTEVAPALSV---------FNDIKELGIPASVDLVSSDPSHMVASFSKGYTSIFNMETQQRILTLETTANSSCQINRVISHPTLSISITAHEDRHIKFYDNNTGK---LIHSMVAHLEAVTSLAVDPNGLYLMSG------SHDCSIRLWNLESKTCIQEFTAHEESIHDVAFHPSKCYIASAGADALAKVF............................................................................................................................................................................... 779
12 -66.100[S] KOG0283 WD40 repeat-containing protein  ali follow..  11  233.LTSVMSNARVGAFFLIKNLDTGKEKELMRRENVNRINYEPLMDLRKFNSYLSKSVRLSKRRGAALLKNIKGVAHRVADKDVSDGSTDSPKKGKDHKHGKANEWVKVRELSALHMCQEIQAHEGAVWTIKFSQDAHYLASGGADRVIHVWEVQECELM-----SMNEGSLTPIHPSLCDSSGNEITVVEKKKKGKGSSGRRHNHIPDYVHVPETKPVCSLKGHLDAILDLSWSKSQL--LLSSSMDKTVRLWDIETKTCLK--------------LFAHNDYVTCIQFSPDENYFLSGSLDAKIRIWSIQDR----HVVEWSDLHEMVTAACYTPDGQGALIGSHKGICRAYDTEDCK--VQSNKKSQAKRKITSFQFSPVNPSEVLVTS-----ADSRIRILDGSEVIHKFKGFRNTCSQLSASYSQDGKYIICASEDSQVYLWKNDFHRTRSTLTTQSHEHFHCK-----DVSAAVPWHGHVRGEPPPVQIHSKRHSKRISTSSQPSSTIS-SPTKEETSATGPTTSNRNKKSGLPPMPKKAATKSQIQPEEEAGPELGSTAWGMVIVTATVHGEIRSYQ----NFGLPRRIGRQTT..................... 901
13 -65.700[S] KOG0295 WD40 repeat-containing protein  ali follow..  17  1...................MSLSERQKEEINRAIAEYMQNNGYSESFSVFLKESSLSENDIKPLGGILEKKWTTRLQRKVNDLESKLQESQREINHGAPTRDKRQAADWIPRPPETQKLTGHRLPITRVIFHPLWTIMASCSEDATIKVWDYETGQLE-----RTLKGHTDAVNDIAIDAAGKQLVSCSSDLSIKLWDFGQT------------DCLKSLKGHEHTVSSVTFLPTGD-FVLSASRDHTIKQWDISTGYCV-------------YTFRGHNDWVRMIRISNDGTLFASASLDQTVTVWSFATKSA---KLVLRDHEHAVECVEWAPDTAILFSGSRDRSIKAWNINTGD---VLFTLLAHENWVRGLAFHPKGKYLISV------ADDKTLRVWELSAQRCMKAIEAHEHFVSTVAFHQTSPFVITGSVDMSCKVWECR............................................................................................................................................................................ 404
14 -65.700[R] KOG0286 G-protein beta subunit  ali follow..  14  1..................................................................MGEMEQLRQEAEQLKKQIADARKACADVTLAEL--VSGLEVVGRVQMRTRRTLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKV-----HAIPLRSSWVMTCAYAPSGNFVACGGLDNMCSIYNLKS--------REGNVKVSRELSAHTGYLSCCRFLDDNN--IVTSSGDTTCALWDIETGQQK-------------TVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTC---RQTFTGHESDINAICFFPNGEAICTGSDDASCRLFDLRADQE-LICFSHESIICGITSVAFSLSGRLLFAG------YDDFNCNVWDSMKSERVGILSGHDNRVSCLGVTADGMAVATGSWDSFLKIWN.............................................................................................................................................................................. 340
15 -65.600[R] KOG0288 WD40 repeat protein TipD  ali follow..  14  42.LSKPLISQGSEWKEKTEKLETELQQCYKARSQLEEMTSRVQKAETENKMLIDRWMLQKMQDAERLNEANDLYEEMLAKLKANGLETLARQQVDGIVRRNEDGTDHFVETIPSTCANRIHAHEGGCGSIVFEYNSGTLFTGGQDRAVKMWDTNSGTLI-----KSLYGSLGNILDMAVTHDNKSVIAATSSNNLFVWDVSSGRV------------RHTLTGHTDKVCAVDVSKFSSRHVVSAAYDRTIKLWDLHKGYCTNTV--------------LFTSNCNAICLSIDGLTVFSGHMDGNLRLWDIQTGKL---LSEVAGHSSAVTSVSLSRNGNRILTSGRDNVHNVFDTRTLEICGTLRASGNRASNWSRSCISPDDDYVAAGSA------DGSVHVWSLSKGNIVSILKEQTSPILCCSWSGIGKPLASADKNGYVCTWT.............................................................................................................................................................................. 515
16 -65.300[U] KOG0276 Vesicle coat complex COPI, beta` subunit  ali follow..  12  4.............................RLEIKRKLAQRSERVKSVDLHPTEPWILASLYSGTLCIWNYQTQVKSFEVTELPVRSAKFVARKQWVVAGADDMYIRVYNYNTMDKVKVFEAHSDYIRCVAVHPTLPYVLSSSDDMLIKLWDWEKGWACTQ----IFEGHSHYVMQVTFNPKDNTFASASLDRTIKIWNLGSPDPNFTL------------DAHQKGVNCVDYFTGGDKYLITGSDDHTAKVWDYQTKSCV-------------QTLEGHTHNVSAVCFHPELPIIITGSEDGTVRIWHATTYRL---ENTLNYGLERVWAIGYIKSSRRVVIGYDEGTIMVKLGREIP----VASMDNTGKIIWAKHNEIQTANIKSIG------ADYEVTDGERLPLS-VKELGTCDLYPQSLKHNPNGRFVVVCGDGEYIIYTALAWRSSEGECAVRESSSKIKIFSKNFQEKRSIRPTFSAEKIFGGTLLAMCSSDFICF------DWAECRLIQRIDVTVKNLYWADSGDLVAIASDTSFYILKFNRDLVTSHFDSGRPENDERVRTGIWVGDCFIYNNSSWKL................................ 544
17 -65.000[K] KOG0263 Transcription initiation factor TFIID, subunit TAF5 (also component of histone acetyltransferase SAGA)  ali follow..  13  162...HFLFENVSNGGSIIIKLIN-QHIDIHIVPGRPTVLENAKVINEQEGITGQSFERGDAQLQPVKLQQMPMDKEKIVEMDLEEEDMMHQNDPNNQSPKLLKEFRKLHEPNAEDAPSRDYIPLPPHKGVDILSEVEAVKDW--SKRLHLGPRASLPSVC----YTFHHTNNNMNCAEFSPDSTMIACGFQESYIRLWSIKADKKSLPKSTSEDSDGSVRLLSHSGPVYGTTFSPDNK-YLLSCSEDASARLWSVDTKTAL-------------VAYKGHTGPVWDVAFGPFGHYFATASHDQTAQLWSCDHIY---PLRVFAGHLSDVDCVTFHPNSAYVLTGSSDKTCRLWDVHRGH---SVRVFNGHTQPVTAVAIAPDGHTMASA------DSEGLIHLWDIGTGRRIKTMRGHRGNIYSLSFSRESTVLVSGGSDCTVRAWDVFKTNYNNPVSSSLTGSVVTPFSAKTSTFNEVN---------------------------WSTSPDQMVALYTKQTPIFNVSFTRRNLCLAISVS............................................................................... 643
18 -64.400[A] KOG0285 Pleiotropic regulator 1  ali follow..  10  2..............IALNREV--------ETQSLKKLSLKSVRRAREIFSPVHGQFPQPDPEGGVEPASKPTRHNSEKTAPLKALALPGPKGSKELRKSATEKALVVGPT-LPPRDLNNTGNPGKSTAILPAPGSFLSTAALMERMPSRWPRPEWHAPWKNYR-VLQGHLGWVRSVAFDPSNEWFCTGSADRTIKIWDVATGVL------------KLTLTGHIGQVRGLAVSNRHT-YMFSAGDDKQVKCWDLEQNKVI-------------RSYHGHLHGVYCLALHPTLDVVLTGGRDSVCRVWDIRTKMQIFVL----PHDSDVFSVLARPTDPQVITGSHDSTIKFWDLRYGK---SMATITNHKKTVRAMALHPKENDFVSASA------DNIKKFSLPKGEFCHNMLSLQRDIINAVAVNEDG-VMVTGGDKGGLWFWDWKSGHNFQRAETIV-----------------------------------------------------QPGSLESEAGIYAACYDQTGSRLVTCEGDKTIKMWKEDEDATPETHPNFKPPKEIRRF................................................. 477
19 -64.300[B] KOG0273 Beta-transducin family (WD-40 repeat) protein  ali follow..  10  31.ESHISQSNINGTLVPPSALISILQKGLQIVAVIPDVVQMRQQAFGEKLTQQQASAAATEASAMAKAATMTPAAIKNREATVNGEENGAHEINNHSKPMEIDGDVEIPP----NKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQGGHDVPSNKDVTSLDWNSDGTLLAMGSYDGFARIWTENGNL-------------ASTLGQHKGPIFALKWNKKGN-YVLSAGVDKTTIIWDAHTGEAK-------------QQFPFHSAPALDVDWQNNMT-FASCSTDMCIHVCRLGCDH---PVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDA---CVHDLQAHSKEIYTIKWSPTGPATSNPNSSASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNTQSGSLVHSYQGTGG--------------------------------------------------------------IFEVCWNARGDKVGASASDGSVCVLDL...................................................................... 522
20 -64.200[A] KOG0284 Polyadenylation factor I complex, subunit PFS2  ali follow..  12  21.STSSMQNSQPRIMNNHHHPHNRFQREHVMPDVMGDGPGRRLRKNVANVRRHVDYVSTVLNHCENRLW---------QYGKQRILQQPDILYQQYAVPADSTPDVPVDCILTKFIRTAMNKVKCPVYSVCWSPEGKRLITGCQTGEFTLWNGTAFNFE-----TILQAHDSAIRALKWASNEQWLLSADQGGYVKYWQPNMNNAHMF------------SAHKDEAIRGLAFAPTDV-KFATASDDGTARVWDFARYTEE-------------RVLRGHGAEVRCIDWHPTKGLIATGSRDTPVKIWDPKSGSC---LATLQEHKSSVMAVEFNKNGNWLLTGGRDHLVKMYDIRMMKE---MRTYRAHKKEVISLAWHPIHEGLFVSG-----GGDGSIVYWMVDGEKEIGLLHAHDQAIWSMKWHPLGHILATGSNDNNTKFWARNFGLSNTNMIGHLDKEREPRMAPPKPSIETQEMMTTDSTLLVPDDLTRQNFAPMIGAKRTLIKQPPAKKAQRQFERMWNNSKGIGAGSDDFTTMKGGLGREDAEGAQ.................................................................. 560
21 -63.500[S] KOG2106 Uncharacterized conserved protein, contains HELP and WD40 domains  ali follow..  145.TGETVYFIA--SVVVLYNVEE---------QLQRHYAGHNDDVKCLAVHPDRITIATGQVAGTVRIWDSVTLNTLIGFFDRAVTCIAFSNGGTNLCADSNDHVLSVWDWQKEEKLADVKCSNEAVFAADFHPTDTNIIVTCGEITSLLLDTRRKLPLIRSKDYSRTRKAKVVLCVTFSENGD-TITGDSSGNILVWGKGTNRIS-----------YAVQGAHEGGISPLCMLRDGT-LVSGGGKDRKLISWSGNYQKLRKTEIPEQFGPIRTPITQGHTDELWGLAIHASKPQFLTCGHDKHATLWDAVGH----RPVWDKIIEDPAQSSGFHPSGSVVAVGTLTGRWFVFDTETKD---LVTVHTDGNEQLSVMRYSPDGNFLAIG------SHDNCIYIYGVSDNGRVGKCSGHSSFITHLDWSVNSQFLVSNSGDYEILYWVPSACKQVVSVETTRDIEWATYTCTLGPEGSDGTDINAVCRAHEKKLLSTGDDFGKVHLFSYPCSQFRAHIYGGHSSHVTNVDFLCEDSLISTGGKDTSIMQWRV...................................................................... 716
22 -63.500[D] KOG0267 Microtubule severing protein katanin p80 subunit B (contains WD40 repeats)  ali follow..  12  2...........................................................................SLCGHTSPVDSVAFNSEEVLVLAGASSGVIKLWDLEESKMVRAFTGHRSNCSAVEFHPFGEFLASGSSDTNLRVWDTRKKGCI-----QTYKGHTRGISTIEFSPDGRWVVSGGLDNVVKVWDLTAGKL------------LHEFKCHEGPIRSLDFHPLEF-LLATGSADRTVKFWDLETFELI-------------GTTRPEATGVRAIAFHPDGQTLFCGLDDG-LKVYSWEPVIC---RDGVDMGWSTL-GDFCINEGKFIGCSYYRNSVGIWVSDISEEPYGAVSEDKNECMVKRFSVLNDQSERMGSGP------------------RGSVSPDYETREIKNIYVDSTGGNLNVAQNPGSLKATLPLESGKVATM--VSEKQNAAYFGPAGDK------YSSTSRDSDSGEESSYSERESIPFSRTKSG----MLLRPAHVRKTLAKFEESKQSAVVQSATRKKSGLAVEEEPQTQNAFLSEFEKALSSEPPTDEANRMFLKPPRIHRSSNSKYNDTRRAMSADPATFGKGGMENSGD. 500
23 -63.400[A] KOG0265 U5 snRNP-specific protein-like factor and related proteins  ali follow..  18  12..........................................................................LAQEAKRSKNDLMAYTNRDKALLESGVRRTSNLQAP-----IMQLEGHEGEIFTAEFHPEGELLLSSGFDRQIYIWQVYEDCENVM----AMSGHSGAVMEAHFTPDGSHIFTCSTDKTLAFWDIATGQR------------QRRFKGHGNFVNSVQGSRRGQQLLCSGSDDRTIKIWDARKKHAAHTL--------------ESPFQVTAVCFGDTGEQVISGGIDNEVKIWDIRKQAV---LHHLRGHSDTITGMSLSPEGDFILTNAMDNTLRVWDVRPYAPGERCVKVFNFEKNLLRCAWSPGSDKITSGSA------DRHVYIWDVNTRRILYKLPGHNGSVNAVDFSPKEPLILSGSSDKTLYLGEIDE........................................................................................................................................................................... 347
24 -62.700[A] KOG1272 WD40-repeat-containing subunit of the 18S rRNA processing complex  ali follow..  12  6.EDNNLMEKVLPPVEQVLTWT--------LIQICMQESDVELETKVKKYLRGEGANLETLKDKKLKTQLASREKGKSAKAAAKIEKWLLPAEAGYLETEGLEKTWRVKDILSSRNQYDIVLPDFGPYKLDFTASGRHMLAGGRKGHLALLDMMNMSLI------KEIQVRETVRDVAFLHNDQFFAAAQKKYAY-IYGRDGTEL--------------HCLKERGPVARLRFLKNH-FLLASVNMSGQLHYQDVTHGGMV-------------ASIRTGKGRTDVMEVNPYNSVVGLGHSGGTVTMWKPTSQA---PLVQMQCHPGPVSSVAFHPNGHLMATSGKERKIKIWDLRKFEEVQTI-----HSFHAKTLSFSQKGLLAAGT--------GSFVQILGDSSGGSSHNSMVKGYQIEKVMFRPYEDVIGIGHSMGWSSILIPGSGEPNFDSWVAN--------------------------------------------------------------PFETSKQRREKEVLLDKLPPETIMLDPSKIGAMRPSRRKEKPSRGEIEAEKEVAIEA---NKTKGRNKPSKRTKKKKEMVENAKRTFPEQEHNTAIKK 526
25 -62.700[A] KOG0640 mRNA cleavage stimulating factor complex; subunit 1  ali follow..  15  3.DEILDPSNLVKNREILYRLMISQ----------LMYDGLEKFAMELSMLVKADQCAPSERLLHVMIAGMQTLSDTNSDDVLPGIDLEFEPEASALAPEPHSYETAY-----------VTSHKQACRAGAFSCDGSLVATGSVDASIKILDVERMEQQGHPVIRTLYDHTDEVSYLEFHPKEHILASASRDGTVKLFDIAKPSVKK----------AHKVFTDCEPVLCLSFHPTGD-YVAIGTEHNVLRVYDVATTQCFVS----------AIPSQQHKAGVTCVKYSPTGKLYATGSYDGDIKIWDGISGRCINTIAEAHG-GAAICSLEFTRNGKYLLSSGMDSLVYLWELCTSRPIQTYTTTGKQEHQTEAVFNHTEDYVLFPDEA------TTSLCSWNSRNGCRLTNSLGHNGPVRYITHSPNGPAFLTCSDDFRARFWYRRANNQ........................................................................................................................................................................ 424
26 -62.600[S] KOG0282 mRNA splicing factor  ali follow..  16  176.EKRKKFKENDASNIDGFLGPWA---------KYVDEKDVAKPSEEEQKELDEITAKRQKKGKQEEEKPGEEKTLHVKEMYDYQGRSYLHIPQDVGVNLRSTMPPEKCYL-PKKQIHVWSGHTKGVSAVRLFPLGHLLLSCSMDCKIKLWEVYGERRCLR----TFIGHSKAVRDICFNTAGTQFLSAAYDRYLKLWDTETGQCISRFT-------------NRKVPYCVKFNPDEDNLFVAGMSDKKIVQWDIRSGEIV-------------QEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRVWEWDIPVDFKY--IAEPSMHSMPAVTLSPNGKWLACQSMDNQILIFGAQNRFNKKKIFKGHMVAGYACQVDFSPDMSYVISGDG------NGKLNIWDWKTTKLYSRFKAHDKVCIGAVWHPETSKVITCGWDGLIKLWD.............................................................................................................................................................................. 579
27 -62.400[R] KOG0315 G-protein beta subunit-like protein (contains WD40 repeats)  ali follow..  15  3.................................................DQQQLILATGGYDHTIKVWQAHTGNCIKTVETSQVNALDRTPDKTRLAACGYQ-CIRLYDLESNCPVINFDGVQKNVTRLGFQEDGNWMFTAGEDHHVRIWDMIAAPPHC----SRIFDCEAPVNAACLHPNQVEIAMGSQNGSVFLWDVKSERH------------ERIVPEVDASIQDVAISPDGR-YLAAANNKGNCYIWSLTSQDQKMSTLR------PNRKIPAHSRYILRCKFSPDSRLLLTTSGDGTVCIWKTDDFS---KWRELCIENYWVWDAAFSADSKWLFTASSDGIARLWKLQTKS---SIRDYTGHTKAITALSFKDEIPVKSTNIS------DVQSSAKPPTQ------RDNPPGTNNLAFFETVGRVAMNPYMGNTTTELN.............................................................................................................................................................................. 362
28 -61.900[S] KOG0321 WD40 repeat-containing protein L2DTL  ali follow..  14  2...NMDIGKALSDVGGLRDITS-------RANNSLPPTPDSSPAAPSKKHKLYDFLESRGKIETPRKRIVFEKKELLIRQLGGSRSHPFSTKTSRHVGGRLNLETYYSRPSE-----CLMMLNQLPFCLGFANNESLLAVCTETGALELFDSRFYDRQNEENQHGWLAHNNAIFSVNFSKDDSLLATSSGDQTSKVFDLSTQQCITRLG------RRGVDGYHSHSVKQVNFCNDSPYNLVSCSRDGSIIFWDMRTHGITIDGEHFQKPVLRIRENSGRDCSITSATWLPQSTVISSCSANSALKLWDLRTVHTVRPLLTTSKRDFGVTNVCTSPDGERIYAASRDSIIYEYSSRHLNSGFCKTPRLRISSFYVKLACSPDGATLACGGGVQ--DKTSGVVVFDTTRNSSAMLTGGHTKDVTAVDWSSEGQ-LASISDDGSVRVWNSSLHGSAANLRKNFSEIFYWGFSEK..................................................................................................................................................... 490
29 -61.800[A] KOG0272 U4/U6 small nuclear ribonucleoprotein Prp4 (contains WD40 repeats)  ali follow..  12  124.RARQINVSTDDTEIKSNLRQLNEEGPAERRRRLKELLAGLGENAINKRQYEDEERKQQQREQDQATWYHEGPDSLRISLPRAKDRLVRAREALEVPSAARAGRMVEKKLQSLAPLCSQVGDTRPVSSAAFSEDSSLLLTSSWSGLCKLWSVPDCELK-----QTLRGHASYVGGVALRPGVKAMASGGHDGAVKLWGFNNEE------------SIADITGHMPHVSKVAFHPSGR-FLATACYDSSWRLWDLEQKTEV-------------LHQEGHAKPVHCLSYHSDGSVLVTGGLDAFGRVWDLRTGR---CIMFLEGHLGAVFGVDFSPNGFHIATGSQDNTCKIWDLRRRQ---PVYTIPAHTNLISDVKYQQEGSFLVTC------SYDSTTKIWSNKTWQPLKTLQGHDNKVISVDIAPNSQYIATTSFDRTFKLWSPDS........................................................................................................................................................................... 553
30 -61.700[T] KOG4378 Nuclear protein COP1  ali follow..  10  9.SWRLLAASGGD-TVKLFDVSAD----SGDPCVLSYTPSPGCAVNSVKWNHTNLVVASTGEDKKISLWRKNGQSDGGDSAEECLSAISFSKKGSRICSGGTGQIVKIWDLQRKLCIKKLKGHTSTITGVMYNCKDEHLASVSVGGDLIVHNLASGARELKDPNGQVVQFVHVLRLLDYSRSSRLLVTAGDDGTVHLWDTTGRSPK-----------MSWLKQHSAPTAGVCFSPSNEKIIASVGMDKKLYTYDSGSRRSS--------------SCIAYEAPFSSLAFGDNGYILVAGTSNGRVVFYDIRGKPQPVTVLHAFSNSEDVTSLSWQTSKPVIVNEKNYTSEMALLGSTVEDSVVIDPLPSTTPSASQSAMAPGSRGVSASTVNASSVEQTP----NRNHLWPSGPLGRLHALRANDSYNDDMGVFSPIIDVSSVEKWADSEGYNNKDHLVVDNKPSSLL------------------FPSSSKGYSFGDNGSKEHPIFDWKPSSTSKQDDPRAAFSSFGSITPTASSKSEDSALTPPEAWGGDKFSEKFNQLANEKFSDKFSHLHAPSR........................................... 546
31 -61.500[S] KOG0296 Angio-associated migratory cell protein (contains WD40 repeats)  ali follow..  15  1...........................MAEEEENQELYIAENEVEEVKLMDQGVTEDEAEQEQNDTMNNMVMDMSVFFEHKDSVFSVSINPVHSNCASGGGDDLGYIWDITTGEQICQLTGHKDSIVAIDWSFDGTYIATGGMDSQVRLWKSSTGFEF-----ITAFETVDEIVWLSWHPKGLFLAAGCNDGSIWMWSLPSGKV------------VQVMYGHTAPVNAGKFIPPGVKRLATVDDSGTLIVWNPATGAPECRMSSDDHRF--DPGNEETAAGWTSFDCNAEGNVLFLGGSSGKVKVVNINSSHI---LASLEAQTESVEAIALCTALPICACASVDGTVALYDSASLK----FRKSLPHEQAVIDCKFLPNTPYLLTACA------DCVIRKWDVRSGQLLGEYTGHQEPILCMAITPDGKRVVTGSDDTELLVFDCEH........................................................................................................................................................................... 399
32 -60.500[R] KOG1524 WD40 repeat-containing protein CHE-2  ali follow..  25.TEA-ILSAADDHVFLLTNTATNESQQILNMPETFFPTSLHIFPRSQTKGGQNDVFAVSTSDGKINILSRNGKENMVDAHNGAALCARWNSDGTGLLSSGEDGFVKMWSR-SGMLRSVLAQFATAVYCVAWDSTSSNVLYCNADHCYIKSLKMQVAP------IKWKAHDGIILCCDWNPTSDLIVTGGEDLKFKVWDGFGQI-------------LFNSSVHDYPITSISWNTDGT--LFAVGSHNILRLCDKSGWS--------------HSLEKMNAGSVMALSWSPDGTQLAVGTAAGLVFHAHIIDKRLTKNWNTPTMIEYNERTVNIIVQCEKIFLVSDGMTITIFTYEGRKINLNPPGQVMALLDERKIDLANDTLVVRDRA------DNKVLHFFDPTTGKAQGDGNKHEHDIVELTVNQCGRNVAFRDQIGAVHIAMVKTFGVSQRMVKIGSLVEQLVFNDVTNMLCGISEGKIAVWPLPNVAFHDRNLLQKSLIQKNIGSVGKFPQLANFAGNTIVI--KSDGCLLPTGILPFYGTLITMASQSK----------DQAIRLCRSIGNDTMWATFAGLAVLHKNMIVMEIAYAALEDDEKVSLINEIKD.. 652
33 -60.200[T] KOG0279 G protein beta subunit-like protein  ali follow..  20  2.............................................................................................................AEGLVLKGTMCAHTDMVTAIATPVDNSDIVTSSRDKSIILWKLTKEDKSYGVAQRRMTGHSHFVQDVVLSSDGQFALSGSWDGELRLWDLATGES------------TRRFVGHTKDVLSVAFSTDNR-QIVSASRDRTIKLWNTLGECKYT-----------ISEADGHKEWVSCVRFSPNTLVIVSASWDKTVKVWNLQNCKL---RNTLAGHSGYLNTVAVSPDGSLCASGGKDGVILLWDLAEGKKLYSL----EAGSIIHSLCFSPNRYWLCAAT-------ENSIRIWDLESKSVVEDLKTKVIYCTSLNWSADGNTLFSGYTDGVIRVWGIGR........................................................................................................................................................................... 325
34 -58.900[R] KOG2096 WD40 repeat protein  ali follow..  12  2.............................................DSVLVVGIASVILGALIAVLFFGSYFRKREVQSMAKAEPQDPIRNPKSNHPAPKKNHPKSQASDKNQNKDLNTLKGHGDAVTGLCFSSDGKSLATACADGVIRVFKLDDASSKSFRFLRINLPAGGHPTAVAFADDASSIVVACHHMSLYMYGEDKQKDQQIKWDHHHIHEKRSVLTISGATATYGTAD-GSVVIASCSEGTDIVLWHGKTGRNL-------------GHVDTNQLKNHMAAVSPNGRFLAAAAFTADVKVWEIVYQKEVSRVMQLKGHKSAVTWLCFSPNSEQIITASKDGSIRVWNINVRYHPIPLCDSGGNPLHYDRLSLCPEGKILAASH-------GSTLQWLCAETGNVLDTAKAHEGDITCISWAPKAITLGTSGDDKKVKLWEAPKSQSL....................................................................................................................................................................... 454
35 -58.100[R] KOG0289 mRNA splicing factor  ali follow..  17  106.ALYQHDAACRVIARLTKEVTA-------AREALATLKPQAGLIVPQAVPSSQPSVVGAGEPMDLGELVGMTPEIIQKQDKATVLTTERKKRGKTVP----EELVKPEELSKASHVGLHSASIPGILALDLCPDTNKILTGGADKNVVVFDKSSEQIL-----ATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVPNASC------------VQVVRAHESAVTGLSLHATGD-YLLSSSDDQYWAFSDIQTGRVLTKV-----------TDETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERT---NVANFPGHSGPITSIAFSENGYYLATAADDSSVKLWDLRKLKNFKTLQL--DNNFEVKSLIFDQSGTYLALGGTD--------VQIYICKQWTEILHFTEHSGLTTGVAFGHHAKFIASTGMDRSLKFYS.............................................................................................................................................................................. 503
36 -58.000[JT] KOG0643 Translation initiation factor 3, subunit i (eIF-3i)/TGF-beta receptor-interacting protein (TRIP-1)  ali follow..  13  4....................................................................................................................ILLQGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERL-----GTYMGHTGAVWCVDADWDTKHVLTGSADNSCRLWDCETGKQLALL-------------KTNSAVRTCGFDFGGNIIMFSTDKQCFVSFFDLRDPSQI-------DNNEPYMKIPCNDSKITSAVWGPLGECIIAGHESGELNQYSAKSGEV---LVNVKEHSRQINDIQLSRDMTMFVTASKDNTAKLFDSTTLE----HQKTFRTERPVNSAALSPNYDHVVLGGGQSTRIGKFEARFFHLAFEEEFGRVKGHFGPINSVAFHPDGKSYSSGGEDGYVRIHYFDPQYFEFEFEA.................................................................................................................................................................. 325
37 -57.900[A] KOG0268 Sof1-like rRNA processing protein (contains WD40 repeats)  ali follow..  11  1..............MKVKMLS-------RNPDNYVRETKLDLQRVPRNYDPALHPFEVPREYNATKLERVFAKPASLDGHRDGVNCLAKHPEKLAVLSGACDGEVRIWNLTQRNCIRTIQAHEGFVRGICTRFCGTSFFTVGDDKTVKQWKMDGPGYGDEE--EPLHTILGKTVYTGIDHHWKEAVFATCGQQVDIWDEQRTN------------PICSMTWGFDSISSVKFNPIETFLLGSCASDRNIVLYDMRQATPLKKV--------------ILDMRTNTICWNPMEAIFTAANEDYNLYTFDMRAL--DTPVMVHMDHVSAVLDVDYSPTGKEFVSASFDKSIRIFPVDKSRSREVYHT--KRMQHVICVKWTSDSKYIMCGS------DEMNIRLWKANASEKLGVLTSREKAAKKFQHYPHIKRIARH-RHLPKSIYSQIQEQRIMKEARRRKEVNRIKHSKPGSVPLVSEKKKHVVAVVK................................................................................................................................... 445
38 -57.300[S] KOG0293 WD40 repeat-containing protein  ali follow..  13  184..................................SSFISHTTSTPGKESVNSRSKVLEELQTASVIIPEKRLECLVENSLHIQRDSCVFHNTLDSDLSLYSDHQCGKHQI-PSQTAQILESHTDEVWFLQFSHNGKYLASSSKDQTAIIWEISADGHI--SLKHTLVGHHKPVIAILWSPDDRQVLTCGAEEVIRRWDVDSGDC------------VHMYEKGGISPISCGWYPDGQ-GIIAGMTDRSICMWDLDGREKE-------------CWKGQRTQKVSDIAMTDDGKWLVSVCKDSVISLFDREATV-----ERLIEEEDMITSFSLSNDNKYILVNLLNQEIRLWNIEGDPKIVSRYKGKRSRFIIRSCFGGYKQAFIASGS------EDSQVYIWHRSTGKLIVELPGHAGAVNCVSWSPTNLHLASASDDGTIRIWGLDRINQQNQKKVQGSSSNGVIHRCNGN................................................................................................................................................... 589
39 -57.300[R] KOG2394 WD40 protein DMR-N9  ali follow..  11  4....................TSNGMISAPSSSSSPAANPQSPGIKTYFKTPEGKYKLHYEKTHSSGLLHYAHGKTVTQKERAAPSTPTGTSSGYSASSGFRSATARLLGTGNGSRALSFVGGNGSMTNTNFDGKGTYLVFNVSDAFICDLNSQEKDPVKS-----IHFSNSNPMCHAFAKDGHDLLIGLNSGDVYTVSLRQQLQDVSKKLVGALH--GSVNNRQDRCTSISWVPGGDGAFVVAHADGNLYNKDGATESTFPAIRDPTQFSVDVARWHICQGSINSIAFSNDGAHLATVGRDGYLRIFDFLTQKL---VCGGKSYYGALLCCSWSMDGKYILTGGEDDLVQVWSMEDRK---VVAWGEGHNSWVSGVAFDSNWSSPNSDGSGGSVGQDTQLLLWDLEMDEIVVPLRRAPGGSPTYSTGSSAHWDNVGTLQPAPCKRDVPKLSPIIAHRVHTEPLSGLMFTQES--------------------VVTACREGHIKIWTRPSESQTNSSEANPTTALLSTSFTKDNKASLSSKIISGSTFKQ....................................................................... 556
40 -57.000[ABO] KOG1446 Histone H3 (Lys4) methyltransferase complex and RNA cleavage factor II complex, subunit SWD2  ali follow..  18  2.......................................................................................................KIKLIDVRSFKVAKIFRENTDKINAIDFAPNGEHLISCSEDDQIVIYDCEKGTQS-----RTVNSKKYGVDLIHFTHANNTAIHSSTDDTIRYLSLHDNKY------------LRYFPGHTKKVISLCISPVE-DTFLSGSLDKTLRLWDLRSPNCQGLM---------------HLSGRPIAAYDPEGLIFAAGVNSESIKLYDLRSFDKGPTFKLNQEKECDWTGLKFSRDGKTILISTNGSVIRLVDAFHGTPLQTFTGYPNNKGIPIEASFSPDSQFIFSGS------TDGRVHIWNADTGNKVSVLNGHPGPVQCVQFNPKYMMLASACTNMAFWLPTSEEG.......................................................................................................................................................................... 316
41 -56.700[R] KOG0645 WD40 repeat protein  ali follow..  14  1.......................................................................................................................SGHTGRLWSVAAHPMLPLFATSSQDKSVRIYNSNTYNLV----HVIDGFHTRSIRRVAWRPIERVLAVASFDSVVSINEKIDDD-----------ECTAALEGHENEVKCIAWSCNGN-YLATCSRDKSVWIWEATEDD----------EFDCLAVLQEHTQDVKVVTWHPTEDLLVSGSYDNSICFWRDDGDD--ALTCQLQGHTNTVWALAFSPNGNTLASADNDGNVFLWIKISSNEDVQTSLPHIHKGAVYTISWMNDATLCSAGG-------DGKIVVYQREKHDEEQDHAHGVYEINSLEYLRDD-RLLSGGDDGECRVWSFK............................................................................................................................................................................ 322
42 -56.600[S] KOG1407 WD40 repeat protein  ali follow..  15  2....................................................................................................EETTIPFKSL----HSREYQGHKKKVHSVAWNSNGTKLASGSVDQTARIWNIEPHGHSKAKDLEL-KGHTDSVDQLCWDPKHSLVATASGDKSVRLWDARSGKCTQQV-------------ELSGENINITYKPDGT-HVAVGNRDDELTILDVRKFKPLHR--------------RKFNYEVNEIAWNMPGDFFFLTTGLGTVEVLSYPSLK---PLDTLTAHTAGCYCIAIDPKGRYFAVGSADSLVSLWDISDML---CLRTFTKLEWPVRTISFNYSGEYIASAS------EDLFIDIANVQTGRTVHQIPCRAA-MNSVEWNPKYNLLAYAGDDKNPKYNTDEGV.......................................................................................................................................................................... 306
43 -55.900[S] KOG0316 Conserved WD40 repeat-containing protein  ali follow..  12  1................................................................MSATELPTKEHILKGHEGAVLAARFNGDGNYALTCGKDRTIRLWNPHRGILIKTYKSHGREVRDVHVTSDNAKFCSCGGDRQVYYWDVSTGRVI-----RKFRGHDGEVNAVKFNDSSSVVVSAGFDRSLRVWDCRSHSV------------EPVQIIDTFLDTVMSVVLTKTE-IIGGSVDGTVRTFDMRIGREMSDNLGQP---------------VNCISISNDGNCVLAGCLDSTLRLLDRTTGEL---LQVYKGHISKKTDCCLTNSDAHVIGGSEDGLVFFWDLVDAK----VLSKFRAHDLVNSIDVDFYLRLLKFFVA----GDKRELPPEGRLYVDFFGRWYNSLEKMKKQQILTSIDFVIYVSNSPFFFYYR.............................................................................................................................................................................. 342
44 -55.800[S] KOG0310 Conserved WD40 repeat-containing protein  ali follow..  12  2.........................................................AQPYLPAEKFLSRKQEILLDEDEPAVVSSVRISPKKPYHVATTSSVRLTLYDTVVCEPLNLFSRFKKGVCSIDFRHDGRLLAIGGDEGKVRIFDVEKTTGSSKVALRVMQASQSTVKSVHFSPRGDTVFSMADDGKIKQYRVADTAYGVN-------VPIIEIQAHEDAIRCGAVSSINDHIVLTGGYDHKVRLWDIRSKEKSLEL--------------DCEHPVESVLFLPGEQLIATAA-GPIVKIWDTTTGR---QLTALQAHYKTVTSLRLATNSTCLLSAGIDRRVNAFRTTNYS----LINSWSMPSPVLDIDVSRDDQTMAIGMG------NLLALYRRAEIKKEATASAAIEDKRSLIRTSAPPVKLVEKDRDMQK-VDVVAKNADKLKIPKIDGMLSNFKHAAVIKLLF------------GGKFRSAMDTAVVSYLRVIVMRGAIHRALAGQERSLNHNLYKAQYFSTLKEVVNAFFDVYALEKLDKKMISSLIGSIDLIVSTTKMNVK-----SSSTALIEDNDVFGEPTIRARD---DELKPSDQGAEEE 539
45 -55.700[R] KOG2055 WD40 repeat protein  ali follow..  13  118.RLRKLRQYEDEDMVNGLQYARRLRTQALSEKSVIPKSLKSLFKSSVSYINQSSKLLAPGTINIKRLKDANF----QAPSHSGIRCMSIHPYFPLLLTCGFDRTLRIYQLKVNPLVTSLHLRSSALQTALFHPDGKRVIAAGRRKYMYIWDLESAQVQKVSRMYGQENFQPSMERFHVDPTGKYIALEGRSGHINLLHALTGQFATSFK-------------IEGVLSDVLFTSDGS-EMLVLSYGAEVWHFNVEQRSVVRRWQVQ------------DGVSTTHFCLDPSNKYLAIGSKSGIVNIYDLQTSNADAAVTTLDNITFSINSMSFSQDSQVLAIASKKDTLRLVHVPSFSVFRNWPTSATPLGRVTCLAFGKGGELCVGNE-------AGRVGLWKLAHYDLKFVPDKII--NWEIRLGKFGYVLLGIQIDVVI.................................................................................................................................................................................. 555
46 -55.600[R] KOG4227 WD40 repeat protein  ali follow..  11  4.........................................................................RAGLGGSMRSVVGFLSQRGLHGDPLLTQDFQRRRLRGCRNLYKKDLLGHFGCVNAIEFSNNGGQLVSGGDDRRVLLWHMEQAIHSRVKPIQLKGEHHSNIFCLAFNSGNTKVFSGGNDEQVILHDVESSETLDVF-------------AHEDAVYGLSVSPVNDNIFASSSDDGRVLIWDIRESPH-----------GEPFCLANYPSAFHSVMFNPEPRLLATANSKEGVGLWDIRKPQSSLLRYGGNLSLQSAMSVRFNSNGTQLLALRRRLPPVLYDIHSRLPVFQFDQGYFNSCTMKSCCFAGDRQYILSGS------DDFNLYMWRIPANGAFMVLKGHRSIVNQVRFNPHTYMICSSGVEKIIKIWSYKQPGCTGDLDGRIEDDSRCLYTHE-----------------EYISLVLNSGSGLSHDYANQSVQEDPRMMAFFDSLVRREIEGWSSDSDSDLSESTILQLHAGVSERSGYTDSESS......................................................... 462
47 -54.600[S] KOG1409 Uncharacterized conserved protein, contains WD40 repeats and FYVE domains  ali follow..  2..AAIINQRVEQGESSMGG---------AKPALLHRITGHVARINDVILLSKDEGVWTASDDRSVRLYLKRDNDQIHHFMPVAPTSLYYSEETYKLLVGLINGNVYEFSVASMTESRKWTCHAGPISGLGFALSSELIFSCSRDKSIVWHCSENSNK--------MGSYLLENSCTAMVIDLPFVFVGDHGGHVTVLRIVDNQ-----------NLVSKLSAHTNAITSLTWDGNKK-VLYSGSSDHLIIMWDIGGGRGE------------AYELNGHNGKVTTLCAAPAAKRLFSADEHGKLMCWDMNCKRV---ETPEWKTSDCCQKCPFFWNLQAMWQRKVVGLRQHHCRTCGS--------------AVCGSCCDNWTTYPPM------GYETKIRICNDCNLTPLAIPHEIHTGITAMHLQETLGLLVTSGQNRVIMIWDVRSVCSAPS..................................................................................................................................................................... 412
48 -54.300[R] KOG1334 WD40 repeat protein  ali follow..  12  167...ASTENQNTDSESSSEDVELESMGEGLFGYPLPRMCPRCGGTNHDQCLLDEDQALEEW---------ISSETSALPRSRWQVLTALRQRQLGSSARFVYEACGARTFVQRFRLQYLLGSHAGSVSTIHFNQRGTRLASSGDDLRVIVWDWVRQKPV----LNFESGHDINVIQAKFFPNDSTLAMCGHDGQVRVAELINASYCENTK---------RVAKHRGPAHELALEPDSPYKFLTSGEDAVVFTIDLRQDR--------PASKVVVTRENDKKVGLYTISMNPANYQFAVGGHDQFVRIYDQRRKKFTPHHLVYCDFPTNITCVVYSHDGTELLASYNDEDIYLFNSSLSDGAQYVKRYKGHRNNKCVNFYGPRSEFVVSGS------DCGHVFFWEKSSSQIIQFMEGRGDIVNCLEPHPYLPVLATSGLDQHVRIW-TPTAKTATELTGLKDVIKKNK------------------QERDEDNLNYTDSFDNRMLRFFVRH---LLQRAHQPGWRDHGAEFPDEEELDESSSTSDTSEEE....................................................................... 671
49 -54.200[R] KOG1273 WD40 repeat protein  ali follow..  14  2.......................................................................................................NAPIIDPLQGDFPEVIELEHGVIKCVAFNHRGSLLAAGCADGGCVIWDFETRGIAKEIRDN---DCSAAITSVSWSKYGHRLLVSAADKSLTLWDVSTGEKIARTILQQTPLQARLACPLSSAPMIVDFDIDCTT-LLPVSVPEMPDVLAPPQRS--------------KCPESNPPFSPAAACFNKCGDLVYIGNSKGEILIVDYKSVRVLAL--VSASGAAPVKNIVFSRNGQYLLTNSHDRTIRIYENLLPATLFREFQDSVTKMHWKAPCFSGDGEWVVGGSAC---KGEHKIYIWDR-AGHLVKILEGPKEALIDLAWHPVHPIIVSVSLAGLVYIWAKDYTENWSAFAPDFKELEE-----------------NEEYVEREDEFDLIPETEKVKVLDVNEDEE-VDIDTVEKDAFSDSDMSVEELRYLPAEPIPDTNDQQVESIKLIEGQISASPASEEAGQNGHHASSP......................................... 463
50 -53.400[J] KOG0650 WD40 repeat nucleolar protein Bop1, involved in ribosome biogenesis  ali follow..  12  319.DTSREHMRRIHDPVSAPKRDL---HAESYNPPPEYLFDAKETKEWLKLKDEPHKRKLHFMPQKFKSLEVPAYSRYLRERFLRCLDLYLCPRAKRVKLNIDAEYLIPKQPFPTVESMVYRGHTDLVRSVSVEPKGEYLVSGSDDKTVKIWEIATGRCIRTI------ETDEVVRCVAWCPNPKSIIAVATGNRLLLVNPKVGDKVLVKKTDDLLKGVRVVITHFKPIRQVTWHGRGD-YLATVMPEGANRIHQLSKRRSQ-------------IPFSKSKGLIQFVLFHPVKPCFFVAT-QHNIRIYDLVKQEL---VKKLLTNSKWISGMSIHPKGDNLLVSTYDKKMLWFDLDLSTKP--YQTMRLHRNAVRSVAFHLRYPLFASGS------DDQAVIVSHGMVYNPLKKLQTHEFGVLDVNWHPVQPWVFSTGADSTIRLY............................................................................................................................................................................... 783
51 -52.800[Z] KOG1523 Actin-related protein Arp2/3 complex, subunit ARPC1/p41-ARC  ali follow..  12  2..........................................................................SLHQFLLEPITCHAWNRDRTQIALSPNNHEVHIYKKNGSQKAHELKEHNGHITGIDWAPKSDRIVTCGADRNAYVWSQKDGV----KPTLVILRINRAATFVKWSPLENKFAVGSGARLISVCYFEA--------ENDWWVSKHIKKPIRSTVLSLDWHPNN-VLLAAGSCDFKCRVFSAYIKEVDEKSKMPFGQLMSEFGGSGTGGWVHGVSFSASGSRLAWVSHDSTVSVADASKSV---QVSTLKTEFLPLLSVSFVSENSVVAA-GHDCCPMLFIYDDRGC---LTFVSKLDIPKQSIQRNMSAMERFRNMDKRATTEDRNTAL-----------ETLHQNSITQVSIKQDCRKFCTTGIDGAMTIWDFKTLESS....................................................................................................................................................................... 363
52 -52.800[I] KOG0301 Phospholipase A2-activating protein (contains WD40 repeats)  ali follow..  11  1....MADDGLGDVPMETESMP--------QYTISHVIEAHKSDTKALAVTQGGC-LISGGRDETVKFWAKKGKQAFEQPKGITVNSIAYAEDGWRLFVGRRDGTIAVFGPSQAEPYAIFNEHKQNVCCLHINEKATHMLSGSWDSNVIIWPITELNSSSFT-TIVCPGHTLSVWALASFPDLNTYLSASADKTIRMWFGDT---------------LSVFKGHTDVVRALVVLSSSH--FLSAGNDGHIIHWDVASASILRKFATQAHEFI--------------YSMTLSDSHILTTGEDGTLEFWAIDGGKAIVSEAVIQLPTTNTWDAKVLLNSD-IAVAGSDGRIYIMTTDKNRK-ADDDILDAFDAEVVAKLTAKTERMKQEEHETVT-----KVDIDDRPTQLNLKYKKGTDPGLCAQEFLSENNLPIHYLEEITRFIKDRIPEARAFDLKSGKKVI---------VDGKEYDYALGVNFGKGEPDKQMPFNVNESPQFAAQRFVERHQLPVSVIPSLAGISQEMDKLSKGAASAQSGYEDPFTGPGRYVPQGSSNSGGHGADPFTGSGRYVP--GFDTGFSGDPLTGDGGYRASAPENTGSHAVPLSSLPQNK 578
53 -52.000[YU] KOG2445 Nuclear pore complex component (sc Seh1)  ali follow..  13  2...................................................................................................................QPFDSGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELS-DSWRAHDSSIVAIDWASPGRIIASASYDKTVKLWEEDPDQEECSGRR----NKLCTLNDSKGSLYSVKFAPAHGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFEKLAVSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSYQLIATGCKDGRIRIFKITEKLSPLASE---ESLTNSNMFDNSADVDMDAQGRSDSNT--EEKAELQSNLQVELLSEHDDHNGEVWSVSWNLTGTILSSAGDDGKVRLWKATYSNEMSVITAQQ................................................................................................................................................................ 349
54 -51.600[A] KOG0299 U3 snoRNP-associated protein (contains WD40 repeats)  ali follow..  11  103..ASRLKEDVLEKKGQMYLDYTSKINPDVKIETAQLRGRHMRPLVGVVAYENF--VYSADKSGLIQKWEALQEKDTRENDDHEIGKAIKLHFR---------------PIKFSRSRRGENDHVKEITCLAISNDGRWIVTGGLDHRIVIRDSVTLEPQ-----HCWKHHRDAVMGLAMRRGTNEMFSCSADRSIKVWSLDQMSY------------IETLFGHQDVIFGVDALARER-CVSVGGRDRTSRLWKIVEESQLVFRSGGTS----MKATAGYMEGSVDCVAMIDEDHFVTGSDNGVIALWSVQRKKTSPDPVTIPPQPRWITSLAAIPYSNLFASGSWDGNIRLWKIAEGLEPLTIATPLSVYGCINSLSLSLQGKGKQSEVRFAACGRETRVGRWKTLRGIP-NSGFVFNIPLTVIPSVTDGDEID.......................................................................................................................................................................................... 523
55 -51.600[R] KOG2321 WD40 repeat protein  ali follow..  2................................SLKVQNPNNVRVYTVSGEGVTQRLPNWISKRKLKKDYALSHRIEL-EYPEASNRIKCTRDGKYAATGVYKPHIKVFDFAEMSLKFERHTDAENVQFEILSDDWTKSVHLQTDRTVDFHSQGGIHYSTRI--------PKYGRDLKYHYPNCDLYLAAAGDEVYRLNLEQGRFLNPLK-----IESAQIDSPTGGVNVIDINPMHQ-LLAFGTDAGSVEFWDPRDRSRVGIL--EIPSTVPSTPYSDNSRSVTALKYRNDGLNVAIGLSDGATLLYDLRSS--SPYMSKDQGYSMPIKSLHWMDDGTARVLSADSKIIKIWEKDTGK----PFSSIEPTVELNDVCPIEGTGLILTAN------EGSPMHAFYIPSLNPAPRWSFLDNITEEMEENPDDYKFVTKKELLNLGLDHLVGTGVIRAYM-HGFFIDNNLYEKARLIANPFSYEEHRQKIVKERLEKQRASKIRSQNRPKVNAGLASRLSYQENKLRKKTGVTDGPSILEDERFKNVFTDKEFEVDEDTLEYKQLHPSRSEARGLTAAEESEEEKEHTKGIKFSSDEESLSDMEEENETFDALVDRRKTEQQV 573
56 -51.600[BL] KOG1009 Chromatin assembly complex 1 subunit B/CAC2 (contains WD40 repeats)  ali follow..  10  7..........................................................................EIAWHNKEPVYSLDFQHGTARLASAGVDTNVRIWKVEKGEFLSNLARHTKAVNVVRFSPTGEILASGGDDAVILLWKVNDNKEPEQIAVKTLRGHLEDVYDICWATDGNLMASASVDNTAIIWDVSKGQK------------ISIFNEHKSYVQGVTWDPLGQ-YVATLSCDRVLRVYSIQKKRVAFNVSKMLSGIGAEGHDDSMKSFFRRLSFTPDGSLLLTPAGCVESGENVMNTTYVKRPIAHLPCPGKATLAVRCCPYRLVFAVASED-SVLLYDTQQSFPFGYVSNI--HYHTLSDISWSSDGAFLAISST------DGYCSFVTFEKDELGIPLKEKP--VLNMRTPDTAKKTKSQTHRGSSPGPRPVEGTPASRTQDPSSPGTTPPQARQAPAPTVIRDPPSITPAVKSPLPGPSEEKTLQPSSQNTKAHPSRRVTLNTLQAWSKTTPRRINLTPLKTDTPPSSVPTSVISTPSTEEIQSETPGDAQGSPPELKRPRLDENKGGTESLDP............................. 559
57 -51.500[S] KOG4328 WD40 protein  ali follow..  12  99.QSPRLLAPIPFESAYEGY--------GSYTQLVDTLLGIESKSCRGKLVKGEIGVVKDENESPMVRTRSSSRVSKVSKEEPEDDSFSDYVNKEFSIPVKPEKIEFDLDLLTLEPQNVARVVPGRIFVVQFLPNVKMVAAGDKLGNVGFWNLDCGNEEDNDGIYLFTPHSAPVSSIVFQQNSSRVISSSYDGLIRLMDVEKSV-------------FDLVYSTDEAIFSLSQRPNDEQSLYFGQDYGVFNVWDLRAGKSV-------------FHWELHERRINSIDFNPQNPVMATSSTDGTACLWDLRSGAKKPKTLSTVNHSRAVHSAYFSPSGLSLATTSLDNYIGVLSGANFENTCMIYNNTSRWISKFKAVWGWDDSYIYVGNL------SKKIDVINPKLKRTVMELHNPRAIPCRIHCHPNVGTLAGSTAGGQVYVWTTK............................................................................................................................................................................ 516
58 -51.500[S] KOG0281 Beta-TrCP (transducin repeats containing)/Slimb proteins  ali follow..  13  105LDARSLCAA--ELVCKEW-----------------QRVISEGMLWKKLIERMVRTDPLWKGLSESRGWD----QYLFKNRPTDGPPNSFYRSLYPKIIQDIETIESNWRCGRHN-LQRIQCRSENSKGVCLQYDDEKIISGLRDNSIKIWDKTSLECL-----KVLTGHTGSVLCLQY--DERVIVTGSSDSTVRVWDVNTGEV------------LNTLIHHNEAVLHLRFSNGL---MVTCSKDRSIAVWDMASAT----------DITLRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWSTSTCEF---VRTLNGHKRGIACLQY--RDRLVVSGSSDNTIRLWDIECGA---CLRVLEGHEELVRCIRF--DNKRIVSGA------YDGKIKVWDLQSTLCLRTLVEHSGRVFRLQF--DEFQIISSSHDDTILIWDFLNVPPSAQNETRSPSRTYTYIS....................................................................................................................................................... 507
59 -51.500[R] KOG2919 Guanine nucleotide-binding protein  ali follow..  18.DLSLPKLSVTLSAEEILKLR--------SGRPKNAVESPHAGVPMETSLAAEEEANGDEEEESVRVVDIEDTLELTSEAKPEDQELAIAPVLQYFQGALVELGRRCWT--------SSTEAQHYTKGCYWSPDGTCLLVPVHLDGMHVIEMPSDRSLTKLQSEVHVPEGGTVYDCVWYPHMNLWLATRQHEPIHMWDAFDGSLRCSYSG-------YDAVDEVMAAISLAFSHDGEQIY--AGYKRCIKIFDTSRPG-------------RFCDDYPVKFAISCIAQTTAHPTLTCGNWHGYIQHFDLRCSHKQGPLFTLGGHKGGITQLRYGEFGNLFSGARKCDKILQWDMRNYKQPLVELQRHVDTNQRIQFDLASDSNWLASG------DTRGFVNVWDLKKYGDPSVLPLHSDCCNGVALNPAMPILATSSGQ---FHFTDQSAQGD-------------------------------------------------------------NVTLNGTETTELPAPADVNQNQKEVLYENAVVMWWCGQT................................................................... 486
60 -51.400[T] KOG1354 Serine/threonine protein phosphatase 2A, regulatory subunit  ali follow..  12  1......MAGAGGGNDIQWCFSQ-------VKGAVDDDVAEADIISTVEFNHSGELLATGDKGGRVVIFQQEQENKIQGEYNVYSTFQSHEPEFDYLKSL---------------------EIEEKINKIRWLPQKNQFLLSTNDKTIKLWKISELMVEASPRRIFANAHTYHINSISINSDYETYLSAD-DLRINLWHLEITDRSFNIVD----IKPANMEELTEVITAAEFHPNSCNTFVYSSSKGTIRLCDMRASALCDRHSKEPEDPSNRSFFSEIISSISDVKFSHSGRYMMTR-DYLSVKIWDLNME--NRPVETYQVHEYDKFECCWNGSDSVVMTGSYNNFFRMFDRNTKRD---ITLEASRENNKPRTVLKPRKVCASGKRKKDEISVDSL----------------DFNKKILHTAWHPKENIIAVATTNN-LYIFQDKV........................................................................................................................................................................... 446
61 -51.300[R] KOG0646 WD40 repeat protein  ali follow..  13  1MEITVIASSSIDEGIGSWDLK--------TGTEQLQFKPCASPAHGLTAVGEKFLA------------------------------------SSQLSARNTSGSIFYWSWTKPQ-AEVKSYPVEPIKALAANNEGTYLVGGGISGDIYLWEVATGKLL-----KKWHGHYRSVTCLVFSGDDSLLVSGSQDGSIRVWSLIRLFDDFQRQQGNTLY-EHNFNEHTMSVTDIVIDYGGCNVIISSSEDRTCKVWSLSRGKLLKNI--------------IFPSVINALALDPGGCVFYAGARDSKIYIGAINATSEYGTLGSVSEKGKAITCLAYCADGNLLISGSEDGVVCVWDPKSLR---HVRTLIHAKGSRKGPVNN-----IQIVRKTIVANSNKTQVSWKSRGALIPPPLEKYER---PVEDTMDGIVTVDPPPFSDVPVYSSFLSADL....................................................................................................................................................................... 380
62 -51.200[DO] KOG0305 Anaphase promoting complex, Cdc20, Cdh1, and Ama1 subunits  ali follow..  12  1MDSGMRATCTVPEHFLPRKLSKQNLDRFIPNRSAKDFDFANYALTQGSKRNLDEVTSASRKAYMTQLAVVMNQNRILAFRNKPKSLLSTNHSDSPHQNPKPVKPRRYIPQNSERVLAPGLRDDFSLNLLDWGSANVLAIAL--GDTVYLWDASSGSTS---ELVTIDEDKGPVTSINWTQDGLDLAVGLDNSEVQLWDCVSNRQVRTLRGG-------------HESRVGSLAWDN-HILTTGGMDGKIVNNDVRIRSSI------------VETYLGHTEEVCGLKWSESGNKQASGGNDNVVHIWDRSLASSKQTLHRFEEHTAAVRALAWCPFQASLLATGGDGKIKFWNTHTGA----CLNSVETGSQVCSLLWSQSERELLSSHG----FTQNQLTLWKYPSMSKMAELNGHTSRVLFMAQSPNGCTVASAAGDENLRLWNVFGEPPK-TTKKAASKKYPELFSHVNSL.................................................................................................................................................. 443
63 -51.100[D] KOG1036 Mitotic spindle checkpoint protein BUB3, WD repeat superfamily  ali follow..  11  1..........................................................................................................MTTVTPSAGRELSNPPSDGISNLRFSNNSDHLLVSSWDKRVRLYDVSTNSLKGEF------LHGGAVLDCCFHDDFSGFSVGA-DYKVRRIVFNVGKEDILGTHDKAVRCVEFDFSILFFYTLCLFCDVTG-QVITGSWDKTVKCWDPRGASGPERT-----------QVGTYLQPERVYSMSLVGHRLVVATAGRHVNIYDLRNMS-QPEQRRESSLKYQTRCVRCYPNGTGYALSSVEGRVAMEFFDLSEAAQASEAGRDIVYPVNSIAFHPIYGTFATG------GCDGFVNIWDGNNKKRLYQYSKYPTSISALSFSRDGQLLAVASSYTAIFVRSVNEIEVKPKPKVYPNPAA............................................................................................................................................................ 354
64 -50.500[U] KOG0277 Peroxisomal targeting signal type 2 receptor  ali follow..  18  2............................................................................................................SAVCGGAARMLRTPGRHGYAAEFSPLPGRLACATAQGTLLILDPDEAGLRL----FRSFDWNDGLFDVTWSENNEVLITCSGDGSLQLWDTAKAA-----------GPLQVYKEHAQEVYSVDWSQTRGELVVSGSWDQTVKLWDPTVGKSL-------------CTFRGHESIIYSTIWSPIPGCFASASGDQTLRIWDVKAAG---VRIVIPAHQAEILSCDWCKNENLLVTGAVDCSLRGWDLRNVRQP--VFELLGHTYAIRRVKFSPHASVLASCS------YDFTVRFWNFSKPSLLETVEHHTEFTCGLDFSLQSTQVADCSWDETIKIYDPACLTIPA...................................................................................................................................................................... 323
65 -50.500[U] KOG1332 Vesicle coat complex COPII, subunit SEC13  ali follow..  14  6...................................................................................................................NTVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQIL---IADLRGHEGPVWQVAWAHPGNILASCSYDRKVIIWREENGTWEK----------SHEHAGHDSSVNSVCWAPHDGLILACGSSDGAISLLTYTGEGQWEV----------KKINNAHTIGCNAVSWAPAVKRFASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAWAPSTSTIASCSQDGRVFIWTCDDASSNWSPKLLHKFNDVVWHVSWSITANILAVS------GGDNKVTLWKESVDVCISDVNKGQGSVSSVTEGQQNEQ............................................................................................................................................................................................ 322
66 -49.900[R] COG2319 FOG: WD40 repeat  ali follow..  13  89...................IPMTSNKDTISLGRHSSLSRNLVNKTKNASETYQQLLEYAEVERDDNVFTYAKLQK--SDMTQKCPTMVASEKDNKGKLNEKKNRSPENLLPFRILDAPELRDDFYTSLLSWSPKGDLAI--GLAENIYLWSKELGPT------RVLEESIYDVSSVAYSYNGDILAVGRVDGTLQFWQDNERV-------------PRISIHHPGDIGVLAWKPVETNRLLVGKGNGNIFVYDIIWSESTSK------AVLVATITNAHDEQVCGLTWNHDGSQFASGGNDNRVCLFKGSDLR---QPLYVWQQNAAVKALSFCPWQRSLLATGHDKHIRFYNCFNGK----KIDELYCGAQITSIHWSPKYREFSVTFGYSLETVQHRFAVYSWPQLECLVSVLVPDIRCVHSVLTSQTDSIIIASSNETIKFFDLSEESSWHNSRVLTWFDSQILEMLEG.................................................................................................................................................... 525
67 -49.600[T] COG5170 Serine/threonine protein phosphatase 2A, regulatory subunit  ali follow..  12  1....MDDIEDSLDQWKFAQC--------FGDKGDVEDITEADIISAVEFDHTGDYLATGDKGGRVVLFERNHSKKKSLEIEEKINKIRWCKRTNHFLLSTNDKTIKLWKLYEKNLKVVAENNLSDSFHSPMQGPLTTPSQLRLPRLNHHDMIIAAYPR----RVYANAHAYHINSISVNSDAETYISAD-DLRINLWNLSISDHSFNIVDIK----PENMEELTEVITSAEFHPINCNHLMYSSSKGNIKLLDLRQSALPCKLFEDQEDQDSKSFFSEIISSISDVKFSQNGRYILSR-DYLTLKIWDVNME--KAPVKTIPLHDVDKFECTFSGDDKHVLSGSYSNNFGIYPTDSSLPGDRGQIVLQADKAAFRARKSAANNVPKLNAVKNNDWRSQPQAAMGSASVGLDPDNLDYNKKILHASWHPFEDSVAIAATNN-LFVFSK............................................................................................................................................................................. 462
68 -49.300[R] KOG4497 Uncharacterized conserved protein WDR8, contains WD repeats  ali follow..  11  1.................................MNFSEVFKLSSLLCKFSPDGKYLASCVQY-RLVVRDVNTLQILLYTCLDQIQHIEWSADSLFILCAMKRGLVQVWSLEQPEWHCKIDEGSAGLVASCWSPDGRHILNTTEHLRITVWSLCTKSV------SYIKYPKACLQGITFTRDGRYMALAERRDCVSIFVCSDWQL------------LRHFDTDTQDLTGIEWAPNGC-VLAVWDTCLEYKIL----------LYSLDGRLLSTYSAYEWSLGIKSVAWSPSSQFLAVGSYDGKVRILNHVTWKMITEFTDRANPKMGIGMLAFSPDSYFLATRNDNNAVWVWDIQKLR----LFAVLEQLSPVRAFQWDPQQPRLAICTG------GSRLYLWSPAGCMSVQVPGEGDFAVLSLCWHLSGDSMALLSKDHFCLCFEAVVGTACRQLGGHT................................................................................................................................................................ 460
69 -49.200[A] KOG0647 mRNA export protein (contains WD40 repeats)  ali follow..  12  2......................................................................................SFFNRSNTTSALGTSTAMANEKDLAND--IVINSPAEDSISDIAFSPQQDFMFSASSDGKVRIWDVQNGVPQGR----AQHESSSPVLCTRWSNDGTKVASGGCDNALKLYDIASGQ-------------TQQIGMHSAPIKVLRFVPSNTECIVTGSWDKTIKYWDMRQPQPVSTVMMPER--------------VYSMDNKQSLLVVATAERHIAIINLANPTTIFK---ATTSPLKWQTRCVACYNEADGYAIGSVEGRCSIRYIDDGMQKKSGSNGQSLVYPVNSIAFHPLYGTFVTA------GGDGTFNFWDKNQRHRLKGYPTLQASIPVCSFNRNGSVFAYALSYDWHQGHMGNRPDYPNVIRLHA--TTDEEVKEKKKR.................................................................................................................................................. 365
70 -49.000[R] KOG1310 WD40 repeat protein  ali follow..  16  1.........................................................................MDNLSFHDGNIFNLLHTRSQDPSHEVDQRMQFHSSLVRRLSQEQELEGHQGCVNALAWNSNGSLLISGSDDLRINIWNYSSRKLL----HSIDTGHTANIFCTKFVPEDELVVSGAGDAEVRLFNTSRLS--GRAEDDNAIIPSALYQCHTRRVKKLAVEPGNPNVVWSASEDGTLRQHDFRESTSCPPAGTAHQECRALADPPKQTLSLKSCDISARPHLLLVGGSDAFARLYDRRNYFCPMHLSERGRTNLHLTHVTFSPNGEEVLLSYSGEHVYLMNVNNGTGIMQKRRYVGHCNVGTDIKLGQRGEYIASGS------DDGRWFIWEKQTGRLMKVLVGDESVLNCIQCHPFDSVVATSGIDNTIKIWSPTASVPSIVAGGSAGPATANVVEVMESNQQKLS............................................................................................................................................. 721
71 -48.900[Z] KOG0313 Microtubule binding protein YTM1 (contains WD40 repeats)  ali follow..  14  19.DVPFSIPAA----SEIADLSNIINKLLKD-------KNEFHKHVEFDFLIKGQFLRMPLDKHME----------------------------VENISSEEVVEIEYVEKCTAPQPEQCMFHDDWISSIKGAEEW--ILTGSYDKTSRIWSLEGKSI------MTIVGHTDVVKDVAWVKKDSLLLSASMDQTILLWEWNV--------ERNKVKALHCCRGHAGSVDSIAVDGSG-TKFCSGSWDKMLKIWSTVPTDEEDEMEESTNRPRKKQTLSGHMEAVSSVLWSDAEE-ICSASWDHTIRVWDVGSGSLKSTL----TGNKVFNCISYSPLCKRLASGSTDRHIRLWDPRTKDGSLVSLSLTSHTGWVTSVKWSPTHEQQLISG-----SLDNIVKLWDTRSCKPLYDLAAHEDKVLSVDWTDTG-LLLSGGADNKLYSYRYSPTTSH....................................................................................................................................................................... 420
72 -48.900[DK] KOG0973 Histone transcription regulator HIRA, WD repeat superfamily  ali follow..  11  2.....................................................................................................................TFVGHDTSILAIDCHPSGKKFITCGSNGLVVVWNAEPVLDKKKASNEFQVESQSQSNSCRWSPDGKRFAFGSDDSSVSVWEYVGLINSMGSITGGAQKECCVLRGHSMEVLTVEWSPNGK-YLASGSIDYRIIIYNARKLPDRITV------------LNDIQLPVKGLSWDPIGKYLASLEGDKKLRFWATDSWQCVKSVTESNIEETMLTRLDWSPDGKYLMTPAAVRLIKLIQRQTWKSDQFL---AGHHKGTTCVRAMPKNGKRMQLTCAAVGSRDKSISIWVFPGTLKPLFVINNIFNHTVMDFAWCGRNLLACSQDGTVKVIHLSESVIGEMISAMSDLCYQIYSIRPPRYELTDKEEDESQDSFNLSDLSSSANNASFVTCPEDVLIKRKKLVAAQQSSDIQLTKSMEDNSKENESKNSEKTMMEERNKQIDVRKDGKRRIQPVFCGTTTADPMTSLSSEGKKTVAPPPAKRKALAPAVPAKKGEVDLEDSSDSDD 521
73 -48.400[U] KOG0771 Prolactin regulatory element-binding protein/Protein transport protein SEC12p  ali follow..  16  26.EEAVRSKITKDQDDDDDDGSSSSSYIVLSGGGGEGRSGIPNVILICRVDLHTNSLSEQP-------------IGRRVIGTDLPYRMAIHPRQGGLICALPENIIEDDNEEESEKVVKELKDVGQQLSLSFNQDGTVLATGAEDGTLRVFEWPSMKTLLN-----ESKTHASVKSLTFSESGKFLVSLG-APLCRVWDVNASAAIASLSKE-----------KDEMFASCRFSVDNSGVAANTQRGGSIITWDTTSWRRRSS------------KLIKRNNSISAFNVSADGKLLAVGTLEGDVLIIDSTK--MQTNQIVKKAHLGLVTALTFSPDSRCLVSVSFDSRARLTVIKQKGEKRRVY--LWVAALLFVLVYVVLYYLMVAMGII..................................................................................................................................................................................................................................... 382
74 -47.200[R] KOG1188 WD40 repeat protein  ali follow..  11  2.....................................................EKIEEQFANLHIVKCSLGTKEPTY--LGIDTSKTVQAGKENLVAVLCSNGSIRIYDKERLNVLREFSGYPGLLNGVRFANSCDSVYSACTDGTVKCWDARVARE--KPVQLFKGYPSNIFISFDINCNDHIICAGTEDALLVFWDARMNSQNLSTTKDSL---GAYSETHSDDVTQVRFHPSNPNMVVSGSSDGLVNVFDINIDNEEDALV----------TTCNSISSVSCIGWSGKGKQIYCMTHDEGFYWWDLNHQDVREVVNMKEDALDYLIGGLYHEDTLHVIGGTNKGRIHLMNCSMSGLTHVTSLQGGHAATVRSFCWNVQDDSLLTG------GEDAQLLLWKPGAIEKTFTKKESMKIASSVHQRVRVHSNDSYKRRKK................................................................................................................................................................................... 386
75 -47.100[S] KOG0294 WD40 repeat-containing protein  ali follow..  10  3.PEMEIIEATNEELLLGFKLIKSPTDGSVKFELKQTFADSSYARSITSLAVQWPWVASGGTDGRIFVYDMRTRKQSILSHAGRVNTLKFTPDLSLLLSGSDDGHMIATRVGSWTKEYDWQKAGQAVTHVSCHPSSKLALSLGGDQVLNTWNLVNGCVAHKTNLKNKATLDFQTGCLSWSKQGDHFTLSG-PLVLEIWGIENAHVMRRIE-------------MPSKPICITWLDGN--ECLTGLDNGNIAWISLKDEDDTP-----------PTFILAHEVRVKAIAYL--NEFLATVSIAGQIKVWKIDMETRKLEEIARSFMDCRPTDLGLLDLRQFGNVRPVEQRTKVEEKPKAKVESDQSAKPAAPRGFVTIEYEQDKKLDAEKKK------EKKKNKKDEESSESNSSEDKENDDFSDSDSDVSSDHGHRKRKPMKREQQPTPASKGK....................................................................................................................................................................... 427

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Zhao Y, Hong DH, Pawlyk B, Yue G, Adamian M, Grynberg M, Godzik A., Li T. The retinitis pigmentosa GTPase regulator (RPGR)- interacting protein: subserving RPGR function and participating in disk morphogenesis. Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):3965-70. Epub 2003 Mar 21.