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Query: [R] KOG1489 Predicted GTP-binding protein (ODN superfamily), from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MSIAWSSVFKRELRLERFLPRVYSTKVPDNAPRAADNEQWLETLRPITHPEQKKSDHDVSYTRHINVPLGEVTSVNYLQRYNKHKHSQGNFVDVRIVKCKSGAGGSGAVSFFRDAGRSIGPPDGGDGGAGGSVYIQAVAGLGSLAKMKTTYTAEDGEAGAARQLDGMRGRDVLIQVPVGTVVKWCLPPQKVRELVEREMRKDNNATLRSILGSTAVNLSVSSGSHRKKIQLYRHEMAESWLFKDKAKEYHENKDWFKDLHKKMEAYDHSLEQSELFNDQFPLAGLDLNQPMTKPVCLLKGGQGGLGNMHFLTNLIRNPRFSKPGRNGLEQHFLFELKSIADLGLIGLPNAGKSTILNKISNAKPKIGHWQFTTLSPTIGTVSLGFGQDVFTVADIPGIIQGASLDKGMGLEFLRHIERSNGWVFVLDLSNKNPLNDLQLLIEEVGTLEKVKTKNILIVCNKVDIDAEKSESFAKYLQVEKFSKSQEWDCVPISALREKTLast
1 -135.000[R] KOG1489 Predicted GTP-binding protein (ODN superfamily)  ali  100  1MSIAWSSVFKRELRLERFLPRVYSTKVPDNAPRAADNEQWLETLRPITHPEQKKSDHDVSYTRHINVPLGEVTSVNYLQRYNKHKHSQGNFVDVRIVKCKSGAGGSGAVSFFRDAGRSIGPPDGGDGGAGGSVYIQAVAGLGSLAKMKTTYTAEDGEAGAARQLDGMRGRDVLIQVPVGTVVKWCLPPQKVRELVEREMRKDNNATLRSILGSTAVNLSVSSGSHRKKIQLYRHEMAESWLFKDKAKEYHENKDWFKDLHKKMEAYDHSLEQSELFNDQFPLAGLDLNQPMTKPVCLLKGGQGGLGNMHFLTNLIRNPRFSKPGRNGLEQHFLFELKSIADLGLIGLPNAGKSTILNKISNAKPKIGHWQFTTLSPTIGTVSLGFGQDVFTVADIPGIIQGASLDKGMGLEFLRHIERSNGWVFVLDLSNKNPLNDLQLLIEEVGTLEKVKTKNILIVCNKVDIDAEKSESFAKYLQVEKFSKSQEWDCVPISALREKT 499
2 -88.300[R] COG0536 Predicted GTPase  ali follow..  35  2........................................................................................NRFIDRVVLHLAAGDGGNGCVSVHREKFKPLGGPDGGNGGHGGDIILEVTAQVHTLLDFHPHVKAERGANGAGDHRNGARGKDLVLEVPPGTVVLN-EKGETLADLTSVGMK----------------------------------------------------------------------------------------------FIAAAGGNGGLGNAALASKARKAPGFALIGEPGEAHDLILELKSMADVGLVGFPSAGKSSLISVMSAAKPKIGDYPFTTLQPNLGVVNVGH--ETFTMADVPGLIPGASEGKGLGLDFLRHIERTSVLVHVVDTATRDPISDIEALEAELAAYQSLSQRPRLVVLNKADVPEAEELAEFLKEDIEK---QFGWPVFIISAVARKG 328
3 -43.400[T] KOG1487 GTP-binding protein DRG1 (ODN superfamily)  ali follow..  21  8...........................................................................................................................................................................................................................................................................................IAEIEAEMAR-TQKNKATAHHLGKARLAKLRRELITPKGGGGGGPGEGFDVAKTGDARIGFVGFPSVGKSTLLSNLAGVYSEVAAYEFTTLTTVPGVIRYKG--AKIQLLDLPGIIEGAKDGKGRGRQVIAVARTCNLILIVLDVL--KPLGHKKIIENELEGFGRLNSKPPNIGFKKKDKGGINLTATCPQSELDA................... 202
4 -42.400[R] COG1163 Predicted GTPase  ali follow..  21  24.........................................................................................................................................................................................................................................................................................................TSFHLGQLKAKLAKLRRELLTSASSGSGGGAGIGFDVARTGVASVGFVGFPSVGKSTLLSKLTGTESEAAEYEFTTLVTVPGVIRYKG--AKIQMLDLPGIIDGAKDGRGRGKQVIAVARTCNLLFIILDVN--KPLHHKQIIEKELEGVGRLNKTPPDILIKKKEKGGISITNTVPLTHLGN................... 203
5 -40.200[R] KOG1490 GTP-binding protein CRFG/NOG1 (ODN superfamily)  ali follow..  19  114............................................................................................................................................................................................................................................................................................VKLLKYGDSLYRCKCLKVAALGRMCTVLKRITPSLAYLEQIRQHMARLPSIDPNTRTVLICGYPNVGKSSFMNKVTRADVDVQPYAFTTKSLFVGHTDYK--YLRYQVIDTPGILDRPFEDRNCSITALAHLRAAVLFFLDISGSCGYTIAQQAALFHSIK--SLFMNKPLVIVCNKTDLMPMENISEEDRKLIEEMKASEEQVLLKMSTLTDEG 337
6 -39.200[T] KOG1486 GTP-binding protein DRG2 (ODN superfamily)  ali follow..  23  7...........................................................................................................................................................................................................................................................................................IKEIEAEMAR-TQKNKATEYHLGQAKLRTQLLEPPKGASGGGEG----FEVTKYGHGRVALIGFPSVGKSTLLTMLTGTHSEAASYEFTTLTCIPGVIHYND--TKIQLLDLPGIIEGASEGKGRGRQVIAVAKSSDLVLMVLDAS--KSEGHRQILTKELEAVGRLNKTPPQIYFKKKKTGGISFNTTAPLTHIDE................... 200
7 -31.900[R] COG1084 Predicted GTPase  ali follow..  20  124............................................................................................................................................................................................................................................................................................................RREAFGRISSVIKRIEGDLDFLDFAKNKLRNMPTVDLDAFTVVIAGFPNVGKSTLLRTLTGAEPEVADYPFTTKGIQIGHLERKW--KRIQVIDTPGLLDRPVEDMNIELQAMVALENADVIMFIFDASETCGYTLESQYSLYLGI-RSVFDIPVVTVFNKMDLAENVKYLEEYINMVE--------DPLKVSAFEGRG 313
8 -29.400[J] COG0012 Predicted GTPase, probable translation factor  ali follow..  25  2....................................................................................................................................................................................................................................................................................................................................................EIGVVGKPNVGKSTFFSAATLVDVEIANYPFTTIDANVGVTYAIAEHPPVKMIDVAGLVPGAHEGRGLGNKFLDDLRMASALIHVVDVTGKDPIEDIEFLEREIDYWI-RINKPMIIAANKADAASEEQ-----INRLIKEGEKRGYIVVPTSAAAE.. 254
9 -23.100[R] KOG1491 Predicted GTP-binding protein (ODN superfamily)  ali follow..  22  1...............................................................................................................................................................................................................................................................................................................................MPPKKQVEEKKVLLGRPGNNLKAGIVGLANVGKSTFFQAITRCPGNPANYPFATIDPEEARVIVPSPRAHLTVYDIAGLTKGASAGEGLGNAFLSHIRSVDSIYQVVRCGDVDPVRDLEIINQELNSMFLLTAKPCIYLINLSERDYIRKKNKHLLRIKEWVKYSPGDLIIPFSVSLEER 272
10 -20.100[R] KOG0075 GTP-binding ADP-ribosylation factor-like protein  ali follow..  21  18................................................................................................................................................................................................................................................................................................................................................KEEMELTLVGLQFSGKTTFVNVIASGQFA------EDMIPTVGMRKITRGNVTIKVWDIGG-------QPRFRSMWERYCRGVNAIVYMVDAADLDKLEASRNELHSLLDKPQLAGIPVLVLGNKRDLPGALDETGLIERMNLSSIQDREICCYSISCKEKDN 169
11 -19.600[R] KOG0074 GTP-binding ADP-ribosylation factor-like protein ARL3  ali follow..  22  17..............................................................................................................................................................................................................................................................................................................................................EVRIL----LLGLDNAGKTTLLKQLASED-------ISHITPTQGIKSVQSQGFKLNVWDIGG-------QRKIRPYWKNYFENTDILIYVIDSADRKRFEETGQELAELLEEEKLSCVPVLIFANKQDLLTAAPASEIAEGLNLHTIRDRVWQIQSCSALTGEG 165
12 -19.600[R] COG3596 Predicted GTPase  ali follow..  13  41.....................................................................................................................................................................................................................................................................................................................................................IGIMGKTGAGKSSLCNALFAGESPVSDVAACTRDPLRFRLQIGE--HFMTIVDLPGVGESGVRDTEYAALYREQLPRLDLILWLIKADDRALATDEHFYRQ---VIGEAYRHKMLFVISQSDKAEPTSGGNILSTEQKQNISRK-HPVCAVSVRLQWG 204
13 -19.500[UZ] KOG0073 GTP-binding ADP-ribosylation factor-like protein ARL2  ali follow..  25  16..............................................................................................................................................................................................................................................................................................................................................ELRLL----MLGLDNAGKTTILKKFNGED-------IDTISPTLGIKTLEHRGFKLNIWDVGG-------QKSLRSYWRNYFESTDGLIWVVDSADRQRMQDCQRELQSLLVEERLAGATLLIFANKQDLPGALSSNAIREALELDSIRSHHWCIQGCSAVTGEN 164
14 -19.000[U] KOG0071 GTP-binding ADP-ribosylation factor Arf6 (dArf3)  ali follow..  20  19................................................................................................................................................................................................................................................................................................................................................NKEMRILMLGLDAAGKTTILYKLKLNQ-------SVVTIPTVGVETVTYKNIKFNVWDVGG-------QDKIRPLWRHYFTGTKGLIFVVDSADSNRISEARQELHRIISDREMRDCLLLVLANKQDLPGALSPAQITDVLQLDKLKDRLWNVQPTCALTGDG 169
15 -19.000[U] KOG0072 GTP-binding ADP-ribosylation factor-like protein ARL1  ali follow..  18  17..............................................................................................................................................................................................................................................................................................................................................EMRIL----ILGLDGAGKTTILYRLQVGE-------VVTTIPTIGVEQVTYKNLKFQVWDLGG-------QTSIRPYWRCYYSNTDAIIYVVDSADRDRIGISKDELLYMLREEELAGAILVVLANKQDMDGCMTVAEVHHALGLENLKNRTFQIFKTSATKGEG 165
16 -18.900[U] KOG0070 GTP-binding ADP-ribosylation factor Arf1  ali follow..  20  17..............................................................................................................................................................................................................................................................................................................................................EMRIL----MVGLDAAGKTTILYKLKLGE-------IVTTIPTIGVETVEYKNISFTVWDVGG-------QDKIRPLWRHYFQNTQGLIFVVDSNDRDRVVEARDELHRMLNEDELRDAVLLVFANKQDLPNAMNAAEITDKLGLHSLRQRHWYIQSTCATSGEG 165
17 -18.800[R] COG1100 GTPase SAR1 and related small G proteins  ali follow..  21  16................................................................................................................................................................................................................................................................................................................................................NKELRILILGLDGAGKTTILYRLQIGE-------VVTTKPTIGVETLSYKNLKLNVWDLGG-------QTSIRPYWRCYYADTAAVIFVVDSTDKDRMSTASKELHLMLQEEELQDAALLVFANKQDQPGALSASEVSKELNLVELKDRSWSIVASSAIKGEG 166
18 -18.800[U] KOG0076 GTP-binding ADP-ribosylation factor-like protein yARL3  ali follow..  19  15................................................................................................................................................................................................................................................................................................................................................KEQYSILILGLDNAGKTTFLETLKKEYSLAFK-ALEKIQPTVGQ----DSKQILKFWDVGG-------QESLRSMWSEYYSLCHGIIFIVDSSDRERLDECSTTLQSVVMDEEIEGVPILMLANKQDRQDRVQDIKEVFNKIAEHISARDSRVLPISALTGEG 174
19 -18.800[R] KOG2486 Predicted GTPase  ali follow..  14  135..................................................................................................................................................................................................................................................................................................................................................LPEFALVGRSNVGKSSLLNSLVRRKRLA-----TSKKPKTQCINHFRINDKWYLVDLPGY-ELKQDWNKFTKDYFLNRSTLVSVFLLVDAS-----IPVKPIDLEYASWLGQNQVPMTLIFTKCDRKKKKNGGKKPEANIKEFQDLIQGPWIMTSSVTNQG 300
20 -18.700[R] KOG0410 Predicted GTP binding protein  ali follow..  19  118...............................................................................................................................................................................YLVGVERKGDGECLFNIEESLEELEQLADTAGLAVVGSTYQKLASPNPRTYIGSGKVAEIKSAINALDVETVIFD------DELSPGQLRNLEKAFGGDVRVCDRTALILDITHEAALQVALAQSGGQVKGMGEKQIEVDKR--------RTQIGVLKKELESVRKVSLVGYTNAGKSTLLNQLTGANVLAENRLFATLDPTTRRVQMQNGK-EFLLTDTVGFIQKLPTT--LVAAFLEEIAESSLLVHVVDISHPLAEQQIEAVEKVMSELD-VSSIPKLVVWNKVDRVDDPQKVKLEAEETG--------DTICISALTGEG 460
21 -18.300[E] COG4917 Ethanolamine utilization protein  ali follow..  13  1..................................................................................................................................................................................................................................................................................................................................................MKRIAFVGSVGAGKTTLFNALQGNYTLARKTQAVEFNDK-------------GDIDTPGEY----NHPRWYHALITTLQDVDMLIYVHGANDPES-------RLPAGLLDIGVSKRQIAVISKTDMPDAD--VAATRKLLLETGFEE--PMFELNSHDPQS 134
22 -18.200[P] COG0370 Fe2+ transport system protein B  ali follow..  20  6.....................................................................................................................................................................................................................................................................................................................................................YCILGNPNTGKTSLFNALTGSYEYVGNWSGVTVEKKVGTLR----SKTGKLIDLPGILNPISRDETVVTRFLLE-EKFDCMLNIVDSSQ---------IERNLNLTVQLLEAPVVMGLNMIDVAAGRG----IHLNIQNLAKKLRIPILPVVARSGKG 149
23 -18.200[R] COG0218 Predicted GTPase  ali follow..  19  25..................................................................................................................................................................................................................................................................................................................................................LPEIALAGRSNVGKSSFINTMLNRK----NLARTSGKPKTQLLNFFNIDDKMRFVDVPGY-KEREKWGCMIEEYLTTRENLRAVVSLVDLRHDPSADDV-----QMYEFLKYYEIPVIIVATKADKIPRGKWNKHESAIKKKLNFDPSDDFILFSSVSKAG 183
24 -18.000[U] KOG0077 Vesicle coat complex COPII, GTPase subunit SAR1  ali follow..  20  18................................................................................................................................................................................................................................................................................................................................................QKEAKILFLGLDNAGKTTLLHMLKDER-------LVQHQPTQHSEELSIGKIKFKAFDLGG-------HQIARRVWKDYYAKVDAVVYLVDAYDKERFAESKRELDALLSDEALATVPFLILGNKIDIPYAASEDELRYKVTLGDSGVRPLEVFMCSIVRKMG 180
25 -18.000[U] KOG0090 Signal recognition particle receptor, beta subunit (small G protein superfamily)  ali follow..  17  53................................................................................................................................................................................................................................................................................................................................................TKSNTVLLSGLSGSGKTVLFYQLRDGSSHQGAV--TSMEPNEGTFVLHNENNPVHLIDVPG-------HSRLISKLEEYLPRAAAVVFVVDALELPNIRAASEYLYDILTNASVIKNPVLLCCNKTDKVTAHTKEFIRKQMEKEIDKLRVSRSAISTADIAND 216
26 -17.900[R] COG2262 GTPases  ali follow..  19  147..........................................................................................................................................................................................................................................................................................................KGGIGLRGPGETQLETDRRSRLERVEKQREQGRQSRIKADVPTVSLVGYTNAGKSTLFNRITEARVYAADQLFATLDPTLRRIDVADVG-ETVLADTVGFIRHLPHD--LVAAFLQETRQATLLLHVIDAADVRVQENIEAVNTVLEEID-AHEIPTLLVMNKIDMLEDFEPRIDRDEENKP-------IRVWLSAQTGAG 349
27 -17.300[R] COG1159 GTPase  ali follow..  23  11.....................................................................................................................................................................................................................................................................................................................................................IAIVGRPNVGKSTLLNKLLGQKISISRKAQTTRHRIVGIHT--EGPYQAIYVDTPGLHMEEKRNRLMNKAASSSIGDVELVIFVVEGTRWTPDD--EMVLNKLRD----GKAPVILAVNKVDNVQEKVDLLPHLQFLASQMNFL--DIVPISAETGMN 161
28 -15.200[R] KOG0394 Ras-related GTPase  ali follow..  15  1...........................................................................................................................................................................................................................................................................................................................................MPSRRRTLLKVIILGDSGVGKTSLMNQYVNKKFSNQYKATIGADFLTKEVQFEDRLFTLQIWDTAG----QERFQSLGVAFYR----ADCCVLVYDVNSMKSFENLNNWREEFLIQASPSDPPFVLIGNKVDVDDGNSRVVSEKKAKAWCASKGNIPYFETSAKVGTN 164
29 -15.100[R] KOG0080 GTPase Rab18, small G protein superfamily  ali follow..  15  1...........................................................................................................................................................................................................................................................................................................................................MDEDVLTTLKILIIGESGVGKSSLLLRFTDDTFDPELAATIGVDFKVKTISVDGNKAKLAIWDTAG----QERFRTLTPSYYRG---AQGVILVYDVTRRDTFVKLDNWLNELETYCTRNDIVNMLVGNKIDKENREVDRNE-----LKFARKHSMLFIEASAKTCDG 157
30 -15.000[R] KOG0395 Ras-related GTPase  ali follow..  12  5....................................................................................................................................................................................................................................................................................................................................LSSGNCTLSVPAKNSYRMVVLGASRVGKSSIVSRFLNGR--EDQYTPTIEDFHRKVYNIRGDMYQLDILDTSG----NHPFPAMRRLSIL---TGDVFILVFSLDNRESFDEVKRLQKQILEVKSCLKNPMVICGNKNDHGELCRQVPT-TEAELLVSGDENCAYFEVSAKKNTN 178
31 -14.900[R] COG1160 Predicted GTPases  ali follow..  12  6....................................................................................................................................VALVGRPNV--------------GKSTLFNRLTRTR--DALVADFPGLT-----RDRKYGHAHIAGYDFIVIDTGGIDGTEEGVEEKMAEQSLLAIDEADIVLFLVDARAGLTAADIGIANYLRQRQNKITVVVANKTDGIDADSHCAEFYQLGLGE------IEQIAASQGRGVTQLMEQVLAPFAEKMENADENDRTSEEEQDEWEQIAIVGRPNVGKSTLTNRIGEDRVVVFDMPGTTRDSIYIPMERDG--QQYTLIDTAGVRKRGKVHLAV-IKTLQAIQDANVVLLTIDARENISDQD-----LSLLGFILNAGRSLVIVVNKWDGLDQDVKDRVKSELDRRLDFIDFARVHFISALHGSG 373
32 -14.600[R] KOG1673 Ras GTPases  ali follow..  16  78.......................................................................................................................................................................................................................................................................................................................DDTTTEPTVSGRRFGSSSDSDLVSLKIS----LLGDCQTGKTTFVVKYVGDE-------NQSFLEMTGLFYVQGVTISFSIWDVGG----EKRSKDHIPIACKD---AVAILFMFDLTSRSTLNSVFGWYSQARKWNK--TAIPILIGTKFDDFVPPNLQWTIVTQARAYAKVMNASLFFSSATHNIN 254
33 -14.200[U] KOG0096 GTPase Ran/TC4/GSP1 (nuclear protein transport pathway), small G protein superfamily  ali follow..  15  17.......................................................................................................................................................................................................................................................................................................................................................LVGDGGTGKTTFVKRHLTGEFEKKYIATIGVEVHPLSFYTNFGEIKFDVWDTAG----QEKFGGLRDGYYIN---AQCAIIMFDVTSRITYKNVPNWHRDLVRVCE--NIPIVLCGNKVDVKE-----RKVKAKTITFHRKKNLQYYDISAKSNYN 158
34 -14.200[R] KOG0091 GTPase Rab39, small G protein superfamily  ali follow..  18  5..............................................................................................................................................................................................................................................................................................................................................IFEYQFRLILIGDSTVGKSSLLKFFTDGKFAELSDPTVGVDFFARLIEMKDGTQKLQLWDTAG----QERFRSITKSYYRN---SVGVLLVYDISNHASFEHIPLWMMEAQRHIEPHRPVFALVGCKLDLINAGGHREVTTEEAQKFAKQHGLHFVETSARSGAN 163
35 -14.200[TU] KOG1954 Endocytosis/signaling protein EHD1  ali follow..  21  88..............................................................................................................................................................................................................................................................................................................................................DFDAKPMILLVGQYSTGKTTFIRYLLESDPEPTTDRFIAVM---GNALVVDAKKQFTIVDTPGILSGEKQRIDRGYDFTG-AERVDRIILLFDAHKLDISDEFKRCIEALAGNED----KIRIVLNKSDMVDHQQLMRALMWSLGKVFKTPEVSRVYLGS..... 290
36 -14.100[R] COG2229 Predicted GTPase  ali follow..  22  3..............................................................................................................................................................................................................................................................................................................................................ENKII----FTGPVGVGKTTAIAAISDEALTLDRKRNTTVAMDYGAISLDE-DTKVHLYGTPG------------FNFMWEIQGSMGLVLLLDNARTNPLKDLEFFLHSFRGL--LEKAPVVVGITKMDIRSQPGIDVYHKYLAKH---NLNVPVFEIDARKEDD 160
37 -14.000[J] KOG1191 Mitochondrial GTPase  ali follow..  16  193......................................................................................SNGNVVDEVLAVPMLAPR-----SYTREDVVE----------HGSEVCLRRVLRTCVEAGAR---LAEPGEFTLRAFLNGR----------------DLSQAENVEKLISAKSS------------------AAADAALEGIQGGFSSLVKSLRAQCIELLTEIEARLDFEDEMPPLDIESVINKITSMSQD-----VESALDTANYDKLLQSG---------------------------------------LQIAIVGRPNVGKSSLLNAWSKSRAIVTEVAGTTRDVVEANVTVRG--VPITLLDTAGIRETNDIVEKIGVE-ETAAKVADVIIMAVSAVEGWTEEDTELLRKDLFGGLLYLKQPMILVMNKIDCAPPGSCDQLEDQRKKE---EVFHKSVFTSAVTGQG 521
38 -13.800[U] KOG0095 GTPase Rab30, small G protein superfamily  ali follow..  16  5..............................................................................................................................................................................................................................................................................................................................................DYDFLFKIVLIGNAGVGKTCLVRRFTQGLFPPGQGATIGVGFMIKTVEINGEKVKLQIWDTAG----QERFRSITQSYYRS---ANALILTYDITCEESFRCLPEWLREIEQYAS-NKVITVLVGNKIDLAERRE---VSQQRAEEFSEAQDMYYLETSAKESDN 158
39 -13.600[TU] KOG0084 GTPase Rab1/YPT1, small G protein superfamily, and related GTP-binding proteins  ali follow..  18  1...........................................................................................................................................................................................................................................................................................................................................MNPEYDYLFKLLLIGDSGVGKSCLLLRFADDSYLDSYISTIGVDFKIRTVEQDGKTIKLQIWDTAG----QERFRTITSSYYR---GAHGIIVTYDVTDLESFNNVKQWLNEIDRYAS-ENVNKLLVGNKCDLTSQKV---VSTETAKAFADELGIPFLETSAKNATN 157
40 -13.500[U] KOG0092 GTPase Rab5/YPT51 and related small G protein superfamily GTPases  ali follow..  14  1...............................................................................................................................................................................................................................................................................................................................MASRGATRPNGPNTGNKICQFKLVLLGESAVGKSSLVLRFVKGQFHEFQESTIGAAFLTQTVCLDDTTVKFEIWDTAG----QERYHSLAPMYYRG---AQAAIVVYDITNEESFARAKNWVKELQRQAS-PNIVIALSGNKADLANKRAV----FQEAQSYADDNSLLFMETSAKTSMN 169
41 -13.500[R] KOG0079 GTP-binding protein H-ray, small G protein superfamily  ali follow..  16  6..............................................................................................................................................................................................................................................................................................................................................DYDHLFKLLIIGDSGVGKSSLLLRFADNTFSENYITTIGVDFKIRTMDINGQRVKLQIWDTAG----QERFRTITSTYYR----THGVVVVYDVTNGESFGNVKRWLQEIENNCD--SVQKVLVGNKCEENERRV---VLESDARNYAQSMNISFFETSAKEDKN 158
42 -13.500[T] KOG4252 GTP-binding protein  ali follow..  12  5..............................................................................................................................................................................................................................................................................................................................................DMEVAIKMVVVGNGAVGKSSMIQRYCKGIFTKDYKKTIGVDFLERQIQVNDEDVRLMLWDTAG----QEEFDAITKAYYR----AQACVLVFSTTDRGSFEAVSSWREKVVAEVG--DIPTVLVQNKIDLLDDSC---IKNEEAEALAKRLRLRFYRTSVKEDLN 157
43 -13.500[TU] KOG0078 GTP-binding protein SEC4, small G protein superfamily, and related Ras family GTP-binding proteins  ali follow..  16  5..............................................................................................................................................................................................................................................................................................................................................SYDYLIKLLLIGDSGVGKSCLLLRFSEDSFTPSFITTIGIDFKIRTIELDGKRIKLQIWDTAG----QERFRTITTAYYR---GAMGILLLYDVTDKKSFDNVRTWFSNVEQHAS-ENVYKILIGNKCDCEDQRQ---VSFEQGQALADELGVKFLEASAKTNVN 158
44 -13.400[U] KOG0098 GTPase Rab2, small G protein superfamily  ali follow..  18  1.............................................................................................................................................................................................................................................................................................................................................MSYAYLFKYIIIGDTGVGKSCLLLQFTDKRFQPVHDLTIGVEFGARMVTIDGKQIKLQIWDTAG----QESFRSITRSYYR----AAGALLVYDITRRDTFNHLTSWLEDARQHSN-SNMVIMLIGNKSDLEARRE---VKREEGEAFAREHGLVFMETSAKTAAN 155
45 -13.300[U] KOG0093 GTPase Rab3, small G protein superfamily  ali follow..  14  4................................................................................................................................................................................................................................................................................................................................ATDSRYGQKESSDQNFDYMFKILIIGNSSVGKTSFLFRYADDSFTPAFVSTVGIDFKVKTIYRNDKRIKLQIWDTAG----QERYRTITTAYYR---GAMGFILMYDITNEESFNAVQDWSTQIKTYSW-DNAQVLLVGNKCDMEDERVV----SERGRQLADHLGFEFFEASAKDNIN 171
46 -13.300[U] KOG0086 GTPase Rab4, small G protein superfamily  ali follow..  19  1...........................................................................................................................................................................................................................................................................................................................................MAETYDFLFKFLVIGSAGTGKSCLLHQFIENKFKQDSNHTIGVEFGSRVVNVGGKTVKLQIWDTAG----QERFRSVTRSYYR----AAGALLVYDITSRETYNSLAAWLTDARTLAS-PNIVVILCGNKKDLDPERE---VTFLEASRFAQENELMFLETSALTGEN 157
47 -13.300[U] KOG0087 GTPase Rab11/YPT3, small G protein superfamily  ali follow..  16  6..............................................................................................................................................................................................................................................................................................................................................EYDYLFKTVLIGDSGVGKSNLLMRFTRNEFNIESKSTIGVEFATRNIVLDNKKIKAQIWDTAG----QERYRAITSAYYR---GAVGALIVYDITKQSSFDNVGRWLKELREHAD-SNIVIMLVGNKTDLLHLRA---VSTEEAQAFAAENNLSFIETSAMDASN 159
48 -13.200[R] KOG0088 GTPase Rab21, small G protein superfamily  ali follow..  22  8..............................................................................................................................................................................................................................................................................................................................................QKSFKFKIVLLGEGCVGKSSLVLRFVENKFSCKHLSTIQASFQNKTVNVEDCQADLHIWDTAG----QEKYHALGPIYYRG---SNGVLLVFDITDRKSFEKVKNWVLEIKTCLG-NTAEILIVGNKIDLEEERQ---VTRQDAEAYAESEGALYMETSAQDNVG 161
49 -13.200[U] KOG0097 GTPase Rab14, small G protein superfamily  ali follow..  16  7..............................................................................................................................................................................................................................................................................................................................................NYSYIFKYIIIGDMGVGKSCLLHQFTEKKFMADCPHTIGVEFGTRIIEVSGQKIKLQIWDTAG----QERFRAVTRSYYR----AAGALMVYDITRRSTYNHLSSWLTDARNLTN-PNTVIILIGNKADLEAQRD---VTYEEAKQFAEENGLLFLEASAKTGEN 160
50 -13.200[R] KOG0083 GTPase Rab26/Rab37, small G protein superfamily  ali follow..  12  188............................................................................................TVNHKTILLGDSGVGKTSYNTGEFRLGS---GIA--PGGRLNQLLQPKKHSVASFRANCPC-ETDNGPTPLASGSPTRRESLVKPTWQPKTLDKINGIASDDSDDDGYPKRRPSVIVHQRQQSISQQPLLPEYMTSASIFRDHAPQTSQSQSQSHHLPSGNGFMARLNSVRLASATEQQPLLDSGGGVSATAVARPPVAPAPVAPGPGSEGASATLCKNAGRALIRMISSSKAPEEEDEFDIMGKVI----MLGDSGVGKTSLLIRFRD-----GRYVPSYFLSTVGIVVVDGTRVKLQIWDTAG----QERFRSVTHAYYR---DAHALLLLYDVTNKTTYDNIRAWLGEIREYAQ-EDVVIVLIGNKADCSGSERQVK--REDGERLGREHNVPFMETSAKTGLN 619
51 -12.900[U] KOG0094 GTPase Rab6/YPT6/Ryh1, small G protein superfamily  ali follow..  17  14.......................................................................................................................................................................................................................................................................................................................................................FLGDQSVGKTSIITRFMYDKFDTTYQATIGIDFLSKTMYLEDRTVRLQLWDTAG----QERFRSLIPSYIRD---SSVAVVVYDVANRLSFLNTSKWIEEVRNERA-GDVIIVLVGNKTDLVEKRQ---VSIEEGDSKGREYGVMFIETSAKAGFN 158
52 -12.800[R] COG0486 Predicted GTPase  ali follow..  16  65......................................................................................SDGNVLDQGIALYFKAPH-----SFTGEDVLE----------HGGQVVLDLL--LKRILQLEGLRLARPGEFSEQAFLNDK----------------DLAQAEAIADLIDASSEQAARSALKSLQGEFSNKVNQLVD-------------SVIYLRTYVEAAIDFPDEEIDFLADGKIEAHLNDIITQLD---------HVRSEAKQGSILREG---------------------------------------MKVVIAGRPNAGKSSLLNALAGRAAIVTDIAGTTRDVLREHIHIDG--MPLHIIDTAGLREATDEVERIGIV-WSEIEQADRILLMLDSTEADNQDLEKVRSEFLTKLPS--NIPVTIVRNKADLSGENEGIVEQN----------GYTVITLSAKTQQG 375
53 -12.600[U] KOG0081 GTPase Rab27, small G protein superfamily  ali follow..  13  5..............................................................................................................................................................................................................................................................................................................................................DYDYLIKFLALGDSGVGKTSVLYQYTDGKFNSKFITTVGIDFREKRVVYRASRIHLQLWDTAG----QERFRSLTTAFFR---DAMGFLLLFDLTNEQSFLNVRNWISQLQMHAYCENPDIVLCGNKSDLEDQRV---VKEEEAIALAEKYGIPYFETSAANGTN 169
54 -12.500[R] KOG1533 Predicted GTPase  ali follow..  17  38.......................................................................................................................................................................................................................................................................................................................................................VIGAPGAGKSTFCAGLTNLDPANDTMAYAPLGPNGALKKIEANHKKYLIIDCPGQLE-LYKSEGELWKVIRFLEKSGCALHLADSLCSDPSKFISVALSTLATMVTM-EMPQVNCLSKADLFSEDEKYRKLNEAICGVISDFDVSFVPLAVENKES 269
55 -12.400[T] KOG3886 GTP-binding protein  ali follow..  12  26................................................................................................................................................................................................................................................................................................................................PEGSLGWVLPNTAMKKKVL----LMGKSGSGKTSMRSIIANYIARDTRRLGATILDRIHSLQINSGNLVLNLWDCGG--QDTFMENYFTSQRDNIFRNVEVLIYVFDVESRELEKDMHYYQSCLEAILQNSPDAKICLVHKMDLVQEDQRDLIFKEREEDLRRLSRPLECSCTSIWDET 229
56 -12.100[K] KOG1534 Putative transcription factor FET5  ali follow..  14  8.......................................................................................................................................................................................................................................................................................................................................................VCGVASSGKSTFCGALMNLDPAAENFEWEPYGPNGGLIEIGDYDEDYLIFDMPGQIE-LYTHVPILPALIRHLQVT-CAVYLLESQLVDRTKFFAGVLSAMSAMVMM-EVPHINLLSKMDLLKDNPKFHELNRCIVQLIDDFNVNFLPLESGNEES 241
57 -11.700[U] KOG3887 Predicted small GTPase involved in nuclear protein import  ali follow..  17  62..............................................................................................................................................................................................................................................................................................................................................KPRIL----LMGLRRSGKSSIQKVVHKMSPNETLFLESTNKICREDVSN-SSFVNFQIWDFPGQIDFFDPTFDYEMIF----RGTGALIFVIDSQDDYMEALARLHLTVTRAYKVNTDINFEVFIHKVDGLSDDHKIETQRDIHQRANDD............... 203
58 -11.600[P] COG2895 GTPases - Sulfate adenylate transferase subunit 1  ali follow..  18  25................................................................................................................................................................................................................................................................................................................................................KSLLRFLTCGSVDDGKSTLIGRLLHDTRQIYEDQLSSLHNDVAYRYFSTEKRKFIIADTPGMATGAS--------------TCELAILLIDARKG----VLDQTRRHSFISTLLGIKHLVVAINKMDLVDSEETFTRIREDYLTFAGQLDIRFVPLSALEGDN 212
59 -11.600[J] KOG0466 Translation initiation factor 2, gamma subunit (eIF-2gamma; GTPase)  ali follow..  20  35............................................................................................................................................................................................................................................................................................................................................VISRQATINIGTIGHVAHGKSTVVKAISGVHTVGSSMPDEFPTDIPGTKGNFRLVRHVSFVDCPGMLNGAAV--------------MDAALLLIAGNESCPQPQ---TSEHLAAIEIMKLKHILILQNKIDLVK-ERQAKEQYEQILAFVQGEGAPIIPISAQLKYN 231
60 -11.000[L] KOG1532 GTPase XAB1, interacts with DNA repair protein XPA  ali follow..  19  46.......................................................................................................................................................................................................................................................................................................................................................VVGMAGSGKTSFLHRLVNLDPAVMSLPFGALGPNGGILTSLNDQLDYVLVDTPGQIE-IFTWSASGAIITEAFAST-VVTYVVDTPSSSPITFMSNMLYACSILYKT-RLPLVLAFNKTDVADHKFALE........................... 223
61 -10.900[J] KOG0458 Elongation factor 1 alpha  ali follow..  19  165................................................................................................................................................................................................................................................................................................................................................LPHLSFVVLGHVDAGKSTLMGRLLYDLNIVNQSQLRKLQRSICTSHFSTHRANFTIVDAPGAIMGIS--------------QADMAILCVDCSTNAFESGFDLTKEHMLLASSLGIHNLIIAMNKMDNVDSQQRFEEIKSKLLPYLVDDNINWVPISGFSGEG 358
62 -10.500[J] KOG0052 Translation elongation factor EF-1 alpha/Tu  ali follow..  18  3..............................................................................................................................................................................................................................................................................................................................................KEKVHINIVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKDIALWKFETAKYYITIIDAPGMITGTS--------------QADCAVLVVACGTGEFEAGISKTREHALLAQTLGVKQLIVACNKMDSTESEARFTEITNEVSGFIKKKAVPFVPISGFNGDN 200
63 -10.500[OK] COG0378 Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase  ali follow..  12  1...............................................................................................................................................................................................................................................................................................................................................MKRPLIIGVGGPVGAGKTMLIERLTRAGVETGGCPHTAIREDASMNFAAIEEMCDKHPDLQLLF----ESGGDNLSATFSPDLVDFSIYIIDVAQGEKIP---------RKGGQGMIKSDLFIINKVDLAPYVGNVEVMKADTLKSRG--NKDFFVTNLKTDEG 187
64 -10.500[O] KOG0448 Mitofusin 1 GTPase, involved in mitochondrila biogenesis  ali follow..  17  63..............................................................................................................................................................................................................................................................................................................................................KLSIIGEVAFFGRTSSGKSSVINAMLWDK--VLPSGIGHITNCFLSVEGTDGRDDLVLVDSPGTDVTTELDSWI----DKFCLDADVFVLVANSESTLMNTEKHFFH---KVNEWLSKPNIFILNNRWDASASEPEEDVRRQHMERCLHEAQNRIFFVSAKEV.. 288
65 -10.400[R] KOG0393 Ras-related small GTPase, Rho type  ali follow..  15  3..............................................................................................................................................................................................................................................................................................................................................AIKCV----VVGDGAVGKTCLLLSYTTNA---GEYILTVFDTYSTNVMVDGRPINLSLWDTAGQDD---------YDQFRHLSFPQTDVFLVCFALNNP-ASFENVRAEVSHHCP--NTPIILVGTKADLREDRDTIERLRESRLQAKEIKAVKYLECSALTQIG 164
66 -10.200[J] KOG0460 Mitochondrial translation elongation factor Tu  ali follow..  17  51................................................................................................................................................................................................................................................................................................................................................KPHVNIGTIGHVDHGKTTLTAAITKCLSDLGQASFMDITISSAHVEYETANRHYAHVDCPG------------ADYIKNMATMDGAIIVVSATDG----QMPQTREHLLLARQVGVKQIVVYINKVDMVE-PDMIELVEMEMRELLSEDNTPIVSGSALCALE 220
67 -10.200[J] KOG0459 Polypeptide release factor 3  ali follow..  22  99................................................................................................................................................................................................................................................................................................................................................KRHLNVVFIGHVDAGKSTIGGQILFLSGQVDDRQIQKYEKEVGRAHFETESTRFTILDAPGMISGAS--------------QADIGVLVISARKGEFETGYERTREHVQLAKTLGVSKLIVVVNKMDDPTSKERYDEIEQKMVPFLKAKDVVFLPISGLMGKN 295
68 -10.200[J] COG5256 Translation elongation factor EF-1alpha (GTPase)  ali follow..  17  8................................................................................................................................................................................................................................................................................................................................................KPHLNLITIGHVDHGKSTLVGRLLYEHGEIPAHIIEEYRKDLAHRKFETDKYYFTLIDAPGMITGTS--------------QADAAILVISAREGE---VMEQTREHAFLARTLGVPQMVVAINKMDATSSEKRYNEVKADAEKLLRSKDISFVPISGYKGDN 196
69 -10.200[J] COG0050 GTPases - translation elongation factors  ali follow..  14  10................................................................................................................................................................................................................................................................................................................................................KPHVNVGTIGHVDHGKTTLTAAITTVLAKTYGGSARAITINTSHVEYDTPARHYAHVDCPG------------ADYVKNMAQMDGAILVVAATDG----PMPQTREHILLGRQVGVPYIIVFMNKCDMVDDEELLELVEMEVRELLSAPGDDLPVVRGSALKA 178
70 -10.200[M] COG0481 Membrane GTPase LepA  ali follow..  15  1...............................................................................................................................................................................................................................................................................................................................................MKNIRNFSIIAHIDHGKSTLSDRLIQTCGGLSDRE-ITIKAQSVTLNYDGETYQLNFIDTPGHVD-------FSYEVSRSLAACEGALLVVDAGQGVEAQTLANCYTAIEM-----NLEVVPILNKIDLPAAD---ERVAEEIEDIVGIDAMEAVRCSAKTGVG 168
71 -10.000[T] COG1217 Predicted membrane GTPase involved in stress response  ali follow..  11  2...............................................................................................................................................................................................................................................................................................................................................IENLRNIAIIAHVDHGKTTLVDKLLKLSGTLDRMDSNDQEKERGITAIKWNGYNINIVDTPGHAD-----------FGGEVERVMSMLLVVDAQDGPMPQTRFVTQKAFKA-----GLRPIVVVNKIDRPGAR--PDWVIDQIFDLFDNLGATDEQLDF..... 160
72 -9.940[V] KOG1707 Predicted Ras related/Rac-GTP binding protein  ali follow..  12  12................................................................................................................................................................................................................................................................................................................................................PKPIRIVVVGEKGSGKSSLIMAA--ARNTFHPNIPSLLPYTNLPSEFFPDRIPATVIDTSSRPEDKGKVV-------KEVRQADAIVLTFAFDRPETLDRLSKYW--LPLFRQLEVRPIIVAGYEVDNKEAYNHFSIEQITSALMKQYREVETIQWSAQRLDQ 165
73 -9.870[J] KOG0462 Elongation factor-type GTP-binding protein  ali follow..  17  36............................................................................................................................................................................................................................................................................................................................................EFTPDKIRNFGIVAHVDHGKSTLADRLLEMCGAVPPGQKQMLDKL-GIAALRHRGYLLNLIDTPGHVD-----------FSAEVSRSDGILLLVAANQGVQAQTIANFWLAFEK-----NIQIIPVINKIDLPGAD--IKSVETQLKNLFEFNPEECLHISAKSGLN 199
74 -9.790[DZ] COG5019 Septin family protein  ali follow..  11  97....................................................................................................................................................................................................................................................................................................................................................NVLVLGESGSGKSTLVNTLLNRDFGVNPEPTVMINSSAVEIVENGISLQLNVIDTPGFGDFIDNTD-IEGRYDQYLERVHACIFFIQPTG----HAISAM--ELRVMLALHEKVNIIIIAKADTLTDDE-LNFTKEMILRDIQYHNIRIFFPPTYETDD 281
75 -9.770[J] COG5257 Translation initiation factor 2, gamma subunit (eIF-2gamma; GTPase)  ali follow..  20  1.............................................................................................................................................................................................................................................................................................................................................MKNQSEINIGLVGHVDHGKTTLTKALSGVWTTHSEETKRGISIRLGYADITELLRKVSFVDAPGMLSGAA---LMDGAIL-----------VIAANEPCPQPQ---TKEHLMALDVIGVKDVIVVQNKIDIVS-KERALESYREIKEFVKGEDAPIIPVSAQQGAN 185

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Ye Y, Godzik A. Comparative analysis of protein domain organization. Genome Res. 2004 Mar;14(3):343-53.