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Query: [Z] KOG1523 Actin-related protein Arp2/3 complex, subunit ARPC1/p41-ARC, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MSLHQFLLEPITCHAWNRDRTQIALSPNNHEVHIYKKNGSQWVKAHELKEHNGHITGIDWAPKSDRIVTCGADRNAYVWSQKDGVWKPTLVILRINRAATFVKWSPLENKFAVGSGARLISVCYFEAENDWWVSKHIKKPIRSTVLSLDWHPNNVLLAAGSCDFKCRVFSAYIKEVDEKKASTPWGSKMPFGQLMSEFGGSGTGGWVHGVSFSASGSRLAWVSHDSTVSVADASKSVQVSTLKTEFLPLLSVSFVSENSVVAAGHDCCPMLFIYDDRGCLTFVSKLDIPKQSIQRNMSAMERFRNMDKRATTEDRNTALETLHQNSITQVSIYEVDKQDCRKFCTTGIDGAMTIWDFKTLESSIQGLRIMLast
1 -109.000[Z] KOG1523 Actin-related protein Arp2/3 complex, subunit ARPC1/p41-ARC  ali  100  1MSLHQFLLEPITCHAWNRDRTQIALSPNNHEVHIYKKNGSQWVKAHELKEHNGHITGIDWAPKSDRIVTCGADRNAYVWSQKDGVWKPTLVILRINRAATFVKWSPLENKFAVGSGARLISVCYFEAENDWWVSKHIKKPIRSTVLSLDWHPNNVLLAAGSCDFKCRVFSAYIKEVDEKKASTPWGSKMPFGQLMSEFGGSGTGGWVHGVSFSASGSRLAWVSHDSTVSVADASKSVQVSTLKTEFLPLLSVSFVSENSVVAAGHDCCPMLFIYDDRGCLTFVSKLDIPKQSIQRNMSAMERFRNMDKRATTEDRNTALETLHQNSITQVSIYEVDKQDCRKFCTTGIDGAMTIWDFKTLESSIQGLRIM 370
2 -69.000[U] KOG1332 Vesicle coat complex COPII, subunit SEC13  ali follow..  18  7.TVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPGNILASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHGLILACGSSDGAISLLTYTGEGQ-WEVKKINNAHTIGCNAVSWAPAVKRFASGGCDNLIKLWKEEEDG-----------------QWKEEQKLEAHSDWVRDVAWAPSTSTIASCSQDGRVFIWTCDDASSPKLLHKFNDVVWHVSWSITANILAVGGDNKVTLWKESVDGQWVCISDVNKVSASVTEGQQNEQ..................................................................... 322
3 -68.200[D] KOG0642 Cell-cycle nuclear protein, contains WD-40 repeats  ali follow..  456KFTLRSHFDGIRALAFHPIEPVLITASEDHTLKMWNLQKTA-EPIYTFRAHKGPVLCVVMSSNGEQCYSGGTDGLIQGWNTTNPN-VLRGPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWNTTEVAPALSVFNDIKELGIPASVDLVSSDPSHMVASFSKGYTSIFNMETQQRILTLESN-------------VDTTANSSCQINRVISHPTLSISITAHEDRHIKFYDNNTGKLIHSMVAHLEAVTSLAVDPNGLYLMSGSDCSIRLWNLESKTCIQEFTAHR---------------------------------KKFEESIHDVAF----HPSKCYIASAGADALAKVF............... 779
4 -67.500[R] KOG0645 WD40 repeat protein  ali follow..  17  1....SGHTGRLWSVAAHPMLPLFATSSQDKSVRIYNSNTYNLVHVID-GFHTRSIRRVAWRPIERVLAVASFDSVVSINEKIDDDWECTAALEGHENEVKCIAWSCNGNYLATCSRDKSVWIWEATEDDE-FDCLAVLQEHTQDVKVVTWHPTEDLLVSGSYDNSICFWRDDG------------------DDWALTCQLQGHTNTVWALAFSPNGNTLASADNDGNVFLWIKISSNQTSLPHIHKGAVYTISWMNDATLCSAGGDGKIVVYQREKHD------------------------------EALWHVAYEQDHAHGVYEINSLEYLRDD-----RLLSGGDDGECRVWSFK............ 322
5 -66.800[S] KOG0293 WD40 repeat-containing protein  ali follow..  13  267AQILESHTDEVWFLQFSHNGKYLASSSKDQTAIIWEISADHISLKHTLVGHHKPVIAILWSPDDRQVLTCGAEEVIRRWDVDSG--DCVHMYEKGGISPISCGWYPDGQGIIAGMTDRSICMWDLDGRE----KECWKGQRTQKVSDIAMTDDGKWLVSVCKDSVISLFDREAT----------------------VERLIEEEDMITSFSLSNDNKYILVNLLNQEIRLWNIEGDPKISRYKGHKRSIRSCFGGYKQAFIASGSDSQVYIWHRSTGKLIVEL-------------------------------------PGHAGAVNCVSWSPTNL---HMLASASDDGTIRIWGLDRINQQ....... 567
6 -66.300[YU] KOG2445 Nuclear pore complex component (sc Seh1)  ali follow..  12  3.PFDSGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDTSNWELSDSWRAHDSSIVAIDWASPGRIIASASYDKTVKLWEEDPDRWNKLCTLNDSKGSLYSVKFAPAGLKLACLGNDGILRLYDALEPSEMKVLSIPPANHLQSDFCLSWCPSRFEKLAVSALEQAIIYQRG-----------------KDGKLHVAAKLPGHKSLIRSISWAPSYQLIATGCKDGRIRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGR--------------------------------SDSNTEEKAELQSNLQVELLSEHDDHNGEVWSVSW----NLTGTILSSAGDDGKVRLWKATYSNECMSVIT.. 346
7 -64.400[JT] KOG0643 Translation initiation factor 3, subunit i (eIF-3i)/TGF-beta receptor-interacting protein (TRIP-1)  ali follow..  16  5..LLQGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGE--RLGTYMGHTGAVWCVDADWDTKHVLTGSADNSCRLWDCETGK---QLALLKTNSAVRTCGFDFGGNIIMFSTDKQMGYQCFVSSQIDNNEPYMKIPCNDSKITSAVWGPLGECIIAGHESGELNQYSAKSGE--------------------VLVNVKEHSRQINDIQLSRDMTMFVTASKDNTAKLFDSTTLEHQKTFR-TERPVNSAALSPNYDVVLGGGQEAMDVTTTSTRIGKFEARFFH-----------------------LAFEEEFGRVKGHFGPINSVAF----HPDGKSYSSGGEDGYVRIHYFDPQYFEFE..... 322
8 -64.000[R] KOG0289 mRNA splicing factor  ali follow..  13  131LATLKPQAGLIVPQAVPSSQPSVVGAGEPMDLGELVGMTPE-SHVGLHSASIPGILALDLCPDTNKILTGGADKNVVVFDKSSE--QILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVPNAS----CVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQT------------------GRVLTKVTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLATAADSSVKLWDLRKLKNFKTLQDNNFEVKSLIFDQSGTYLALGGTDYICKQWTEILHFTEHSGLTTGVAF----GHHAKFIASTGMDRSLKFYSL............. 504
9 -63.800[S] KOG1409 Uncharacterized conserved protein, contains WD40 repeats and FYVE domains  ali follow..  10  24LHRITGHVARINDVILLSKDEGVWTASDDRSVRLYLKRDNDQFWPSIHHFMPVAPTSLYYSEETYKLLVGLINGNVYEFSVADDSMTESRKWTCHAGPISGLGFALSSELIFSCSRDKSIVWHCSENSN-------KMGSYLLENSCTAMVIDLPFVFVGDHGGHVTVLRIVD------------------NQPNLVSKLSAHTNAITSLTWDGNKKVLYSGSSDHLIIMWDIGGGREAYELNGHNGKVTTLCAAPAAKRLFSADHGKLMCWDMNCKRVETPEWKTSDCCQKCPFFWNLQAMWQRKDNPQNFNLTPLAIPHEIHTGITAMHL----QETLGLLVTSGQNRVIMIWDVRSVCSAPSGSQ.. 415
10 -62.800[K] KOG0263 Transcription initiation factor TFIID, subunit TAF5 (also component of histone acetyltransferase SAGA)  ali follow..  16  317MYTFHHTNNNMNCAEFSPDSTMIACGFQESYIRLWSIKADDSDGSVRLLSHSGPVYGTTFSPDNKYLLSCSEDASARLWSVDTKT--ALVAYKGHTGPVWDVAFGPFGHYFATASHDQTAQLWSCDHIY----PLRVFAGHLSDVDCVTFHPNSAYVLTGSSDKTCRLWDVHRGH--------------------SVRVFNGHTQPVTAVAIAPDGHTMASADSEGLIHLWDIGTGRRIKTMRGHRGNIYSLSFSRESTVLVSGGDCTVRAWDVFKTNYNNPVSSSLTGSVVTPFSAKTSTFNE----NWSTSPDQMVALYTKQTPIFNVSF----TRRNLCLAISVS...................... 643
11 -62.400[S] KOG1407 WD40 repeat protein  ali follow..  15  13SREYQGHKKKVHSVAWNSNGTKLASGSVDQTARIWNIEPHSKAKDLELKGHTDSVDQLCWDPKHSLVATASGDKSVRLWDARSGK---CTQQVELSGENINITYKPDGTHVAVGNRDDELTILDVRKFK-----PLHRRKFNYEVNEIAWNMPGDFFFLTTGLGTVEVLSYPSLK--------------------PLDTLTAHTAGCYCIAIDPKGRYFAVGSADSLVSLWDISDMLCLRTFTKLEWPVRTISFNYSGEYIASASDLFIDIANVQTGRTVHQIPC--------------------------------------RAAMNSVEW----NPKYNLLAYAGDDKNPKYNTDEGVFRIFG..... 311
12 -62.300[ABO] KOG1446 Histone H3 (Lys4) methyltransferase complex and RNA cleavage factor II complex, subunit SWD2  ali follow..  12  16AKIFRENTDKINAIDFAPNGEHLISCSEDDQIVIYDCEKGT--QSRTVNSKKYGVDLIHFTHANNTASSTKVDDTIRYLSLHDN--KYLRYFPGHTKKVISLCISPVEDTFLSGSLDKTLRLWDLRSPNCQGLM------HLSGRPIAAYDPEGLIFAAGVNSESIKLYDLRSFDK---------------GPFVTFKLNQEKECDWTGLKFSRDGKTILISTNGSVIRLVDAFHGTPLQTFTGYPNNPIEASFSPDSQFIFSGSDGRVHIWNADTGNKVSVLNGD------------------------------------HPGPVQCVQF----NPKYMMLASACTNMAFWLPTSEEG.......... 316
13 -61.800[R] KOG0286 G-protein beta subunit  ali follow..  14  8RQEAEQLKKQIADARKACADVTLAEL--VSGLEVVGRVQMR--TRRTLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTT--NKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRFLDDNN-IVTSSGDTTCALWDIETGQ--------------------QKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHESDINAICFFPNGEAICTGSDASCRLFDLRADQELICFSHESCGITSVAFSLSGRLLFAGYDDWDSMKSERVGILSGHDNRVSCLGV----TADGMAVATGSWDSFLKIWN.............. 340
14 -61.700[S] KOG0296 Angio-associated migratory cell protein (contains WD40 repeats)  ali follow..  13  54VQGFFEHKDSVFSVSINPVHSNLASGGGDDLGYIWDITTGE--QICQLTGHKDSIVAIDWSFDGTYIATGGMDSQVRLWKSSTG--FEFITAFETVDEIVWLSWHPKGLFLAAGCNDGSIWMWSLPSGK----VVQVMYGHTAPVNAGKFIPPGKRLATVDDSGTLIVWNPATGAP---------ECRMSSDDHRFDPGNEETAAGWTSFDCNAEGNVLFLGGSSGKVKVVNINSSHILASLEAQTESVEAIALCTALPICACASDGTVALYDSASLKFRKSLP-HEQAVIDCKFLPNTPYLLTACADWDVRSGQLLGEYTGHQEPILCMAI----TPDGKRVVTGSDDTELLVFDCEH........... 399
15 -61.400[T] KOG0279 G protein beta subunit-like protein  ali follow..  13  8KGTMCAHTDMVTAIATPVDNSVIVTSSRDKSIILWKLTKED-VAQRRMTGHSHFVQDVVLSSDGQFALSGSWDGELRLWDLATG--ESTRRFVGHTKDVLSVAFSTDNRQIVSASRDRTIKLWNTLGECK--YTISEADGHKEWVSCVRFSPNTLTIVSASWDKTVKVWNLQNCKL--------------------RNTLAGHSGYLNTVAVSPDGSLCASGGKDGVILLWDLAEGKKLYSLEAGS-IIHSLCFSPNRYWLCAATENSIRIWDLESKSVVEDLKVD---LKAEAEKTDGSTG---------------IGNKTKVIYCTSLNW----SADGNTLFSGYTDGVIRVWGIGR........... 325
16 -61.100[A] KOG0265 U5 snRNP-specific protein-like factor and related proteins  ali follow..  12  11ILAQEAKRSKNDLMAYTNRDKALLESGVRRTSNLQA-------PIMQLEGHEGEIFTAEFHPEGELLLSSGFDRQIYIWQVYEDC-ENVMAMSGHSGAVMEAHFTPDGSHIFTCSTDKTLAFWDIATGQ----RQRRFKGHGNFVNSVQGSRRGQLLCSGSDDRTIKIWDARKKH---------------------AAHTLESPFQVTAVCFGDTGEQVISGGIDNEVKIWDIRKQAVLHHLRGHSDTITGMSLSPEGDFILTNADNTLRVWDVRPYAPGERCHNFEKNLLRCAWSPGSDKITSGSADWDVNTRRILYKLPGHNGSVNAVDF----SPKEPLILSGSSDKTLYLGEIDE........... 347
17 -60.500[B] KOG0273 Beta-transducin family (WD-40 repeat) protein  ali follow..  14  172ATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENS-REGGHDVPSNKDVTSLDWNSDGTLLAMGSYDGFARIWTENG---NLASTLGQHKGPIFALKWNKKGNYVLSAGVDKTTIIWDAHTGE----AKQQFPFHSAPALDVDWQNNMT-FASCSTDMCIHVCRLGCDH--------------------PVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDWNTQSGSLVHSYQGT-GGIFEVCW----NARGDKVGASASDGSVCVLDL............. 522
18 -60.000[R] KOG1334 WD40 repeat protein  ali follow..  13  270QYLLGSHAGSVSTIHFNQRGTRLASSGDDLRVIVWDWVRQK-PVLNFESGHDINVIQAKFFPNDSTLAMCGHDGQVRVAELINAS-ENTKRVAKHRGPAHELALEPDSYKFLTSGEDAVVFTIDLRQDRP--VVVTRENDKKVGLYTISMNPANYQFAVGGHDQFVRIYDQRRIDKKENNGVLKKFTPH-------HLVYCDFPTNITCVVYSHDGTELLASYNDEDIYLFNSSLSDGAQYVKRYKG-KCVNFYGPRSEFVVSGSDCHVFFWEKSSSQIIQFMEG-------------------------------------RGDIVNCLEP----HPYLPVLATSGLDQHVRIWTPTAKT......... 595
19 -59.900[S] KOG0310 Conserved WD40 repeat-containing protein  ali follow..  19ILLDEDEPAVVSSVRISPKKPYHVATTSSVRLTLYDTVVCE--PLNLFSRFKKGVCSIDFRHDGRLLAIGGDEGKVRIFDVEKTT-VALRVMQASQSTVKSVHFSPRGDTVFSMADDGKIKQYRVADTAVNAVPIIEIQAHEDAIRCGAVSSNDHIVLTGGYDHKVRLWDIRSKEKSDCEHPVESVLFLPGEQLIATTALQAHYKTVTSLRLATNSTCLLSAGIDRRVNAFRTTNYSLINSWS-MPSPVLDIDVSRDDQTMAIGGNLLALYRRAEIKKEATASAAIEDKRSLIRTSAPPVKLVEKDRDMQKAKNADKLKIPKIDGMLSNFKHAAVIK--GGKFRSAMDTAVVSYLRIVMRGAIHRALA.. 416
20 -59.700[S] KOG0295 WD40 repeat-containing protein  ali follow..  13  57LRLQRKVNDLESKLQESQREINHGAPTRDKRQAADWIPRPP--ETQKLTGHRLPITRVIFHPLWTIMASCSEDATIKVWDYETG--QLERTLKGHTDAVNDIAIDAAGKQLVSCSSDLSIKLWDFGQTYD---CLKSLKGHEHTVSSVTFLPTGDFVLSASRDHTIKQWDISTGY--------------------CVYTFRGHNDWVRMIRISNDGTLFASASLDQTVTVWSFATKSAKLVLRDHEHAVECVEWAPDTALFSGSRDRSIKAWNINTGDVLFTLLAHENWVRGLAFHPKGKYLISVADDWELSAQRCMKAIEAHEHFVSTVAF----HQTSPFVITGSVDMSCKVWECR............ 404
21 -59.200[S] KOG0308 Conserved WD40 repeat-containing protein  ali follow..  11  23.EHEYSNRSAVSALQYDAQNGRLFTGGSDTIIRTWSVPHHK-QYQGSLEQHTDWVNDMILCGHGKILISASNDTTVKVWNIERDN-GFIDCIRTHKDYVSCLAYAPIVEKAVSASFDHNIFVYDINANFK---TVNNLIGCKDSIYSLATTPNLSLVLGAGTEKCIRLFDPRTNE--------------------KIMKLRGHTDNVRALVVNDDGTRALSAGSDATIRLWDIGQQRCIATCIAHEEGVWTLQVDSSFTTVYSAGDKMVVKTPLYDFTKSQLLFKEEAPVKKLLLSEKDNPVSSDIKRWSIRPSAQLSIGGDEDGPSTSNANHSVSLSDKRHVLTRDSDGNVALYDVLAARKI....... 426
22 -59.000[A] KOG0299 U3 snoRNP-associated protein (contains WD40 repeats)  ali follow..  10  134AQLRGRHMRPLVGVVAYENF--VYSADKSGLIQKWEALQEK-RSRRGENDHVKEITCLAISNDGRWIVTGGLDHRIVIRDSVTL--EPQHCWKHHRDAVMGLAMRRGTNEMFSCSADRSIKVWSLDQMS----YIETLFGHQDVIFGVDALARERCVSVGGRDRTSRLWKIVEESQLVFRSGGT-----------SMKATAGYMEGSVDCVAMIDEDHFVTGSDNGVIALWSVQRKKPLFTIPPQPRWITSLAAIPYSNLFASGSDGNIRLWKIAEGL-------------------------------RSFEPLTIATPLSVYGCINSLSLSLQGKSEVRVFAACGRETRVGRWKTLRGIP........ 500
23 -58.600[S] KOG0282 mRNA splicing factor  ali follow..  14  281IHVWSGHTKGVSAVRLFPLGHLLLSCSMDCKIKLWEVYGER-RCLRTFIGHSKAVRDICFNTAGTQFLSAAYDRYLKLWDTETGQ---CISRFTNRKVPYCVKFNPDEDKFVAGMSDKKIVQWDIRSGE----IVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRVWEWDIPV-------------------DFKYIAEPSMHSMPAVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKKKMVAGYACQVDFSPDMSYVISGDNGKLNIWDWKTTKLYSRF-------------------------------------KAHDKVCIGAVWHPH---ETSKVITCGWDGLIKLWD.............. 579
24 -58.500[S] KOG0271 Notchless-like WD40 repeat-containing protein  ali follow..  13  98SASIPGHGEPVISAQFSPDGRGLASGSGDQTMRIWDIELEL--PLHTCKSHKSWVLCIAWSPDATKIASACKNGEICIWNAKTGE-QIGKTLKRHKQWITSLAWQPTCRLLASCGKDGNIFIWDTVQGT----VVRCLSGHTASVTCLRWGGEGL-IYSGSQDRTVKMWRADDGVMTGHAHWINTLALNTDYALRTSCFEPSKQTRYEAALEIAGGERLVSGSDDFTLFMWNPETKQSINRMTGHMQLVNQVVFSPDTRYIASASDKSVKLWCGRTGKYLASLRGHVGPVYQVAWSADSRLLVSGSADFELKTKSLYYDLPGHGDEVFTVDW----SPEGTKVVSGGKDKVLKLWR.............. 472
25 -58.200[BK] KOG1063 RNA polymerase II elongator complex, subunit ELP2, WD repeat superfamily  ali follow..  14  298.SVLIGHEDWVYSVEWQPPVISILSASMDKTMMIWRPEKKT-VCVGELSHCALGFYGGHWSPNSLSILAHGYGGAFHLWRNVSSSWQMQKVPSGHFAAVTDVTWARTGEYLLSVSQDQTTRVFSAWKNDE--LARPQVHGHDINCVAMVQGKGNHRFVSGAEEKVVRVFEAPLSGGEGSFPEDLQADVQVLGANMSALERNGGGEGLDTFETVPEAAPAELKEPPIEDQLAFHTLWPESHKLYGHGNELFSLCSDHKGNLVASSCKAEIWLWEVGTWKAVGRLQSHSLTVTHLEFSYDDTLLLSVSRDRHFVSHKLMAKVEAHKRIIWACSW----NPFGHQFATSSRDKTVKIWSVENDARIKQILVL. 737
26 -58.200[A] KOG0285 Pleiotropic regulator 1  ali follow..  12  161YRVLQGHLGWVRSVAFDPSNEWFCTGSADRTIKIWDVATGV--LKLTLTGHIGQVRGLAVSNRHTYMFSAGDDKQVKCWDLEQN--KVIRSYHGHLHGVYCLALHPTLDVVLTGGRDSVCRVWDIRTKM-----QIFVLPHDSDVFSVLARPTDPQVITGSHDSTIKFWDLRYGK--------------------SMATITNHKKTVRAMALHPKENDFVSASADNIKKFSLPKGEFCHNMLSLQRDIINAVAVNEDGVMVTGGDKGGLWFWDWKSGHNFQRAE-----------------------------TIVQPGSLESEAGIYAACY----DQTGSRLVTCEGDKTIKMWKEDEDAT........ 460
27 -57.600[Z] KOG0313 Microtubule binding protein YTM1 (contains WD40 repeats)  ali follow..  12  94PEQCMFHDDWISSIKGAEEW--ILTGSYDKTSRIWSLEGK---SIMTIVGHTDVVKDVAWVKKDSLLLSASMDQTILLWEWNVER-KALHCCRGHAGSVDSIAVDGSGTKFCSGSWDKMLKIWSTVPTDETRTPIVTLSGHMEAVSSVLWSDAEE-ICSASWDHTIRVWDVGSGS---------------------LKSTLTGNKVFNCISYSPLCKRLASGSTDRHIRLWDPRTKDVSLSLTSHTGWVTSVKWSPTHELISGSLDNIVKLWDTRSCK------------------------------------APLYDLAAHEDKVLSVDWTDTG-----LLLSGGADNKLYSYRYSPTTSHVGA.... 423
28 -57.500[S] KOG0316 Conserved WD40 repeat-containing protein  ali follow..  13  11AHILKGHEGAVLAARFNGDGNYALTCGKDRTIRLWNPHRGI--LIKTYKSHGREVRDVHVTSDNAKFCSCGGDRQVYYWDVSTG--RVIRKFRGHDGEVNAVKFNDSSSVVVSAGFDRSLRVWDCRSHS----VEPVQIIDTFLDTVMSVVLTKTEIIGGSVDGTVRTFDMRIGRE----------------------MSDNLGQPVNCISISNDGNCVLAGCLDSTLRLLDRTTGELLQVYKGHISKKTDCCLTNSDAHVIGGSDGLVFFWDLVDAKVLSKFRAH--------------------------------------DLVNSIDVDFYLR--LLKFFVAGDKRELPPEGRLYVDFF....... 306
29 -57.400[A] KOG0291 WD40-repeat-containing subunit of the 18S rRNA processing complex  ali follow..  10  138RRRFLGGFDDVTWLDWSSDSRLLAIGCRDSSTKIVAINYTKNFRTYNLSGHTDAIVACFFEANSLHLNTISRNGQLCLWECSLAP---SDLEDAERPKIAPPQRKKEKKAVSDNESEDDVENVVEKDARHYLADEPRKEQRDVQLTAANYNTRTKVLVVAFSSGAFYLYELPDHSLSISDYPISAALFNCTGDWVALMKQQGHSSEMTCIAYSSDGQFIATGGEDSKVKLWNTQSSFCFVTFSEHTSGVTGIQFSRNKKFLVSSSDGTVRAFDVNRYRNFTFTSPNPAQFSCVAVDYSGELVVAGGQDWSVKTGKLLEIISGHEGPVVSIAFSPVA--TSSTLVSGSWDKTVKIWNCLESNSEHE..... 560
30 -57.200[R] KOG2096 WD40 repeat protein  ali follow..  12  79LNTLKGHGDAVTGLCFSSDGKSLATACADGVIRVFKLDDAS-RFLRINLPAGGHPTAVAFADDASSIVVACHHMSSIKWDHHHIH--EKRSVLTISGATATYGTADGSVVIASCSEGTDIVLWHGKTGR----NLGHVDTNQLKNHMAAVSPNGRFLAAAAFTADVKVWEIVYQK------------DGSVKEVSRVMQLKGHKSAVTWLCFSPNSEQIITASKDGSIRVWNINVRYHLCDSGGNPLHYDRLSLCPEGKILAASHGSTLQWLCAETGNVLD------------------------------------TAEKAHEGDITCISWAPKAERHAMVLGTSGDDKKVKLWEAPKSQSL....... 454
31 -57.100[U] KOG0276 Vesicle coat complex COPI, beta` subunit  ali follow..  11  8KRKLAQRSERVKSVDLHPTEPWILASLYSGTLCIWNYQTQV--MAKSFEVTELPVRSAKFVARKQWVVAGADDMYIRVYNYNTM--DKVKVFEAHSDYIRCVAVHPTLPYVLSSSDDMLIKLWDWEKG---WACTQIFEGHSHYVMQVTFNPKDNTFASASLDRTIKIWNLGSPDLDAHQKGVNCVDYFTGGTKSCVQTLEGHTHNVSAVCFHPELPIIITGSEDGTVRIWHATTYRLENTLNYGLERVWAIGYIKSSRRVVIGYDEGTIMVKLGREIPVASMDNTGKIIWAKHNEIQTANIKSIGADYEVRLPLSVKELGTCDLYPQSLKH----NPNGRFVVVCGDGEYIIYTALAWRN......... 386
32 -57.000[A] KOG0640 mRNA cleavage stimulating factor complex; subunit 1  ali follow..  13  99TAYVTSHKQACRAGAFSCDGSLVATGSVDASIKILDVERML-PVIRTLYDHTDEVSYLEFHPKEHILASASRDGTVKLFDIAKPSVKKAHKVFTDCEPVLCLSFHPTGDYVAIGTEHNVLRVYDVATTQCF-VSAIPSQQHKAGVTCVKYSPTGKLYATGSYDGDIKIWDGIS------------------GRCINTIAEAHGGAAICSLEFTRNGKYLLSSGMDSLVYLWELCTSRPIQTYTGQEHQTEAVFNHTEDYVLFPDETTSLCSWNSRNGCRLT------------------------------------LNSLGHNGPVRYITH----SPNGPAFLTCSDDFRARFWYRRANNQ........ 424
33 -56.900[D] KOG0267 Microtubule severing protein katanin p80 subunit B (contains WD40 repeats)  ali follow..  13  2..SLCGHTSPVDSVAFNSEEVLVLAGASSGVIKLWDLEESK--MVRAFTGHRSNCSAVEFHPFGEFLASGSSDTNLRVWDTRKKG--CIQTYKGHTRGISTIEFSPDGRWVVSGGLDNVVKVWDLTAGK----LLHEFKCHEGPIRSLDFHPLEFLLATGSADRTVKFWDLETFEL--------------------IGTTRPEATGVRAIAFHPDGQTLFCGLDDG-LKVYSWEPVICRDGVDMGWSTL-GDFCINEGKFIGCSYRNSVGIWVSDISELEPYEDKNECMVKRFSVLNDQSERMGS-------GPRGSVSPDYETREIKNIYV----DSTGGNLNVAQNPGSLKATLPLESGKV....... 326
34 -56.900[S] KOG4328 WD40 protein  ali follow..  12  208.NVARVVPGRIFVVQFLPNVKMVAAGDKLGNVGFWNLDCGN-DGIYLFTPHSAPVSSIVFQQNSSRVISSSYDGLIRLMDVEKSV---FDLVYSTDEAIFSLSQRPNDEQLYFGQDYGVFNVWDLRAGK----SVFHWELHERRINSIDFNPQNPVMATSSTDGTACLWDLRSMGAKKP----------------KTLSTVNHSRAVHSAYFSPSGLSLATTSLDNYIGVLSGANFENTCMIYHNNTSKFKAVWGWDDSYIYVGNSKKIDVINPKLKRTVMELHNPL-----------------------------------QRAIPCRIHCHPY---NVGTLAGSTAGGQVYVWTTK............ 516
35 -56.800[A] KOG0268 Sof1-like rRNA processing protein (contains WD40 repeats)  ali follow..  11  59LASLDGHRDGVNCLAKHPEKATVLSGACDGEVRIWNLTQRN--CIRTIQAHEGFVRGICTRFCGTSFFTVGDDKTVKQWKMDGPG-DEEEPLHTILGKTVYTGIDHHWKEAVFATCGQQVDIWDEQRTN----PICSMTWGFDSISSVKFNPIETLLGSCASDRNIVLYDMRQATPLKKDMRTNTICWNPMEAFIFTMVHMDHVSAVLDVDYSPTGKEFVSASFDKSIRIFPVDKSRSREVYTKRMQHVICVKWTSDSKYIMCGSEMNIRLWKANASEKLGVLTSREKAAEKFQHYPHIKRIARHRHLYSQIQEQRIMKEARRRKEVNRIKH----SKPGSVPLVSEKKKHV-VAVVK............ 445
36 -56.400[T] KOG4378 Nuclear protein COP1  ali follow..  11  1..........MMSNLVEPSWRLLAASGGD-TVKLFDVSADS-CVLSYTPSPGCAVNSVKWNHTNLVVASTGEDKKISLWRKNGQSLGTVPVGDSAEECLSAISFSKKGSRICSGGTGQIVKIWDLQRKL----CIKKLKGHTSTITGVMYNCKDEHLASVSVGGDLIVHNLASGARATELKDPNG-------------QVVQFVHVLRLLDYSRSSRLLVTAGDDGTVHLWDTTGRSKMSWLKQHSAPTAGVCFSPSNEIASVGMDKKLYTYDSGSRRSSSCIA--------------------------------------YEAPFSSLAF----GDNGYILVAGTSNGRVVFYDIRGKPQPVTVLH.. 310
37 -56.200[A] KOG1272 WD40-repeat-containing subunit of the 18S rRNA processing complex  ali follow..  72YGKSAKAAAKIEKWLLPAEAGYLETEGLEKTWRVKQTD-LSSRNQYDIVLPDFGPYKLDFTASGRHMLAGGRKGHLALLDMMNMS---LIKEIQVRETVRDVAFLHNDQFFAAAQKKYAYIYGRDGTE-------LHCLKERGPVARLRFLKNHFLLASVNMSGQLHYQDVTHGGM--------------------VASIRTGKGRTDVMEVNPYNSVVGLGHSGGTVTMWKPTSQAPLVQMQCHPGPVSSVAFHPNGHLMATGKERKIKIWDLRKFEEVQTI--HSFHAKTLSFSQKGLLAAGTGSGSSHNYTRYMNHSMVKGYQIEKVMF----RPYEDVIGIGHSMGWSSILIPGSGEPNFD..... 417
38 -56.100[U] KOG0277 Peroxisomal targeting signal type 2 receptor  ali follow..  11  9ARMLRTPGRHGYAAEFSPLPGRLACATAQGTLLILDPDEAG-LRLFRSFDWNDGLFDVTWSENNEHLITCSGDGSLQLWDTAKAA-GPLQVYKEHAQEVYSVDWSQTRGLVVSGSWDQTVKLWDPTVGK----SLCTFRGHESIIYSTIWSPIPGCFASASGDQTLRIWDVKAAG--------------------VRIVIPAHQAEILSCDWCKNENLLVTGAVDCSLRGWDLRNRQPVFELLGHTYAIRRVKFSPFHALASCSYDFTVRFWNFSKPD------------------------------------SLLETVEHHTEFTCGLDFSLQSP---TQVADCSWDETIKIYDPACLTIP....... 322
39 -56.000[D] KOG1036 Mitotic spindle checkpoint protein BUB3, WD repeat superfamily  ali follow..  10  10RELSNPPSDGISNLRFSNNSDHLLVSSWDKRVRLYDVSTNSLKGEDILGTHDKAVRCVLFCDVTGQVITGSWDKTVKCWDPRGASGPERTQVGTYLQPERVYSMSLVGHRLVVATAGRHVNIYDLRNMSQ--PEQRRESSLKYQTRCVRCYPNGTGYALSSVEGRVAMEFFDLSEAAQAKK-------YAFKCHRKSEAGRDIVYPVNSIAFHPIYGTFATGGCDGFVNIWDGNNKKRLYQYSKYPTSISALSFSRDGQLLAVASSEAIFVRSVNEIEVKPKPKVYPNPAA............................................................................... 354
40 -55.800[R] KOG0315 G-protein beta subunit-like protein (contains WD40 repeats)  ali follow..  11  31.TMRFVETSQVNALDRTPDKTRLAACGYQ-CIRLYDLESNCTAPVINFDGVQKNVTRLGFQEDGNWMFTAGEDHHVRIWDMIAAP-PHCSRIFDCEAPVNAACLHPNQVEIAMGSQNGSVFLWDVKSER----HERIVPEVDASIQDVAISPDGRYLAAANNKGNCYIWSLTSQD-------------QKMSTLRPNRKIPAHSRYILRCKFSPDSRLLLTTSGDGTVCIWKTDDFSKWRELCIENYWVWDAAFSADSKWLFTASDGIARLWKLQTKSSIRDYTGHTKAITALSFKDEIPVKSTNISDVQSS---PPTQRDNPPGTNNLAFF----ETVGRVAMNPYMGNTTTELN.............. 362
41 -55.600[R] KOG1524 WD40 repeat-containing protein CHE-2  ali follow..  15  7ASRKTRHTEMVCGVGWIGTEA-ILSAADDHVFLLTNTATNNGKVENMVDAHNGAALCARWNSDGTGLLSSGEDGFVKMWSRSG---MLRSVLAQFATAVYCVAWDSTSSNVLYCNADHCYIKSLKMQVA-----PIKWKAHDGIILCCDWNPTSDLIVTGGEDLKFKVWDGFGQNSSVHDYPITSISWNTDGTLFAVSLEKMNAGSVMALSWSPDGTQLAVGTAAGLVFHAHIIDKRLTNTPTMIEYNERTVNIIVQCEIFLVSDGMTITIFTYEGRKNPPGQVMALLDERKIDLANDTLVVRDRADNKVLTGKAQGDGNLKHEHDIVELTVNQCGPLNDRNVAFRDQIGAVHIAMVKTFGVS....... 497
42 -55.300[A] KOG0306 WD40-repeat-containing subunit of the 18S rRNA processing complex  ali follow..  13  408RITIGGHRSDVRTLSFSSDNIAVLSAAAD-SIKIWNRSTLQ----CIRTMTCEYALCSFFVPGDRQVVIGTKTGKLQLYDLASGN--LLETIDAHDGALWSMSLSPDQRGFVTGGADKSVKFWDFELVKRLSVKQTRTLQLDEDVLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKF--------------------FLSLYGHKLPVICMDISHDGALIATGSADRNVKIWGLDFGDCHKSLFAHDDSVMYLQFVPKSHLFFTGKDHKIKQWDADKFEHIQTLEGHHQEIWCLAVSPSGDYVVSSSHDKSLERTREPLILEEEREMEREAEYEESVAKEDQPAVPGETQGDSYFTGKKTIETVKAAERIM 761
43 -55.300[Z] KOG0318 WD40 repeat stress protein/actin interacting protein  ali follow..  14  17.TLPRTQRGQPIVLGADPKGKNFLYTN-GNSVIIRNIENPA--IADVYTEHSCAVNVAKYSPSGFYIASGDASGKIRIWDTVNKEHLLKNEFQPIAGPIKDISWSPDNQRIVAVGEGREGHVFMSETGT----SVGEISGQSKSINSADFRPARPRIVTGSEDNTIAVFEGPPFKF--------------------KMTKQDHSRFVQAVRYSPDGKFFASAGFDGKVFLYDGTSSELVGEFPAHKGGVYALAWKPDSTQLLTSGDKTCRLWTVESRELVEFVMGTTVDDQQVSCLWQGDNLITVSLSGVIDPSKPLRVVKGHNKPITVLGL----SDDRSTIYTGSHDGVVTNWNSGSGTND....... 360
44 -54.900[A] KOG0647 mRNA export protein (contains WD40 repeats)  ali follow..  13  2.............SFFNRSNTTSALGTSTAMANEKDLAND----IVINSPAEDSISDIAFSPQQDFMFSASSDGKVRIWDVQNGV-PQGRAQHESSSPVLCTRWSNDGTKVASGGCDNALKLYDIASGQ-----TQQIGMHSAPIKVLRFPSNTECIVTGSWDKTIKYWDMRQPQ---------------------PVSTVMMPERVYSMDNKQSLLVVATAERHIAIINLANPTTIFKATTSPLKWQTRCVACYNEADGYAIGSEGRCSIRYIDDG------------------MQKKSGFSFKCHRQTNPNRAPGSNGQSLVYPVNSIAF----HPLYGTFVTAGGDGTFNFWDKNQRHRLKG..... 306
45 -54.800[R] KOG1188 WD40 repeat protein  ali follow..  13  27......LGIDTSKTVQAGKENLVAVLCSNGSIRIYDKERLN--VLREFSGYPGLLNGVRFANSCDSVYSACTDGTVKCWDARVAREKPVQLFKGYPSNFISFDINCNDHIICAGTEDALLVFWDARMNSQNLSTTAYSETHSDDVTQVRFHPSNNMVVSGSSDGLVNVFDINIDNEED-----------------ALVTTCNSISSVSCIGWSGKGKQIYCMTHDEGFYWWDLNHLDTDEPVEDALDYLIGGLYHEKTDVIGGTNKGRIHLMNCSMSGLTHVTS----------------------------------LQGGHAATVRSFCW----NVQDDSLLTGGEDAQLLLWKPGAIEKT....... 356
46 -54.700[A] KOG0319 WD40-repeat-containing subunit of the 18S rRNA processing complex  ali follow..  13  269VRKKRIASSNLDHLAYDVVSNRFLAISAEQNLIILDFENLK-IARQIVGFHDEIYSCCLLGKDESHMAVASNTSEIRLYNTKTLD--CQLIRGHTESVLSVVSPTWDTSLLASCSKDNSIIFWRLVTSPETLVPVAAATGHANTVTALAISNTGRFLASVSTDCTIKLWGLGSTKLKEVKIDAEKDFVEQLPKLTCSSTMVAHGKDVNCVDISESDALIATGGMDKLVKLWQVDTHKMAGTLSGHRRGVGDVKFAKNSHKLASCSDMTIKIWNISEKSCLQTISGHSCAVFRVIFARNDSQLISADSAWTIKTADCECSIDAHTDKIWSLSK----NHNESEFVTAGTDGRIVVWKDVTEEKQ....... 642
47 -54.600[R] KOG0322 G-protein beta subunit-like protein GNB1L, contains WD repeats  ali follow..  10  9VFSLRSPDGAVNSLCFQESD-RLLAGTIKGSVFLWDLQTNR--SALHFEVGSDPITSLHHTPDR--LVTQEKGGTITMFSIGGSSYVKERHLGFCRSALHTNTSKTNEQLLFYPCEESSIGVLHVTDAAAPTQILVPDDPQLPTCFKPFECASQLFLLAGYESGHFLTWDISSSVI---------------------LDVMELAQDATSVDYDPVTNRGIVGGPTDKLISFSYQRSQLGSELCIKNPGVNGVRIRPDQKVFASAGDGRIRIFSWKSLRPLAVLTQH------------------------------------KNGGVMDLAFSSQQVWHAPIMAAAGMDGQISLWDLYN........... 323
48 -54.300[S] KOG0321 WD40 repeat-containing protein L2DTL  ali follow..  11  121.ECLMMLNQLPFCLGFANNESLLAVCTETGALELFDSRFYD-RRIHGWLAHNNAIFSVNFSKDDSLLATSSGDQTSKVFDLSTQQLGRRGVDGYHSHSVKQVNFCNDSPNLVSCSRDGSIIFWDMRTHGIT-RKAHENSGRDCSITSATWLPQSTVISSCSANSALKLWDLRTVHTVRPLPAAT----------TPELTTSKRDFGVTNVCTSPDGERIYAASRDSIIYEYSSRHLNSKDPRLRISSFYVKLACSPDGATLACGGTSGVVVFDTTRNC-----------------------------------SSSAMLTGGHTKDVTAVDWSSEG-----QLASISDDGSVRVWNSSLHGSAANLRE.. 476
49 -54.100[B] KOG0639 Transducin-like enhancer of split protein (contains WD40 repeats)  ali follow..  11  477QINTLNHGEVVCAVTISNPTRHVYTGG-KGCVKVWDISHPG-VSQLDCLNRDNYIRSCKLLPDGCTLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQT----LVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGR---------------------QLQQHDFTSQIFSLGYCPTGEWLAVGMESSNVEVLHVNKPD-KYQLHLHESCVLSLKFAYCGKWFVSTGDNLLNAWRTPYGASI--------------------------------------FQSKESSSVLSCDI----SVDDKYIVTGSGDKKATVYEV............. 768
50 -53.600[J] KOG0650 WD40 repeat nucleolar protein Bop1, involved in ribosome biogenesis  ali follow..  10  392.RYLRERFLRCLDLYLCPRAKRVKLNIDAEYLIPKLPSPRD-VESMVYRGHTDLVRSVSVEPKGEYLVSGSDDKTVKIWEIATGR---CIRTIETDEVVRCVAWCPNPKLSIIAVATGNRLLWSNAEADEQEKGVRVVITHFKPIRQVTWHGRGDYLATVMPEGANRSALI------------------QLSKRRSQIPFSKSKGLIQFVLFHPVKPCFFVAT-QHNIRIYDLVKQELVKKLLTNSKWISGMSIHPKGDNLLVSTDKKMLWFDLDSTKPYQTMRLHRNAVRSVAFHLRYPLFASGSDDQAVPLIVPLKKLQTHEFGVLDVNW----HPVQPWVFSTGADSTIRLYT.............. 784
51 -52.900[R] KOG4227 WD40 repeat protein  ali follow..  12  46KKDLLGHFGCVNAIEFSNNGQWLVSGGDDRRVLLWHMEQARVKPIQLKGEHHSNIFCLAFNSGNTKVFSGGNDEQVILHDVESSE---TLDVFAHEDAVYGLSVSPVNNIFASSSDDGRVLIWDIRESPH--GEPFCLANYPSAFHSVMFNPEPRLLATANSKEGVGLWDIRKPQ-----------------SSLLRYGGNLSLQSAMSVRFNSNGTQLLALRRRLPPVLYDIHSRLPVFQFDFNSCTMKSCCFAGDRDILSGSDDFNLYMWRIPADPEAGGIGR--------------------------VVNGAFMVLKGHRSIVNQVRF----NPHTYMICSSGVEKIIKIWSPYKQPGCTGDLD.. 373
52 -52.800[S] KOG0772 Uncharacterized conserved protein, contains WD40 repeat  ali follow..  12  75.QMQQSEAGPSSSRAEGPEDSDDSDFDETEAISIIKLIPAA--CEAKISHGTQAISALRVEPPGVRFASGGLDYYVKLFDFQKMD-YDKELLPAESHVINSLAFSPNGETLVVASGEAIIRLLDRAGGDQYIIDLNITKGHTATVNCVEFNPLNNEFISCSDDGSLRLWNLDDHKVITK-------CINKHRKVIKTKGANGKRVSPQVCTFSPDGKWIAAGCDDGSVQAWKYGSQYNYLVRKAHNGSITSIAFSPDSKRLLSGFDDTLKMWSLDNPKEVKTGLENAFKSTDCGFSPRAEVVFTGTSSPNKDTPGTLQFIDYPGISCHRIQW----HPRLNQIIAGLSDGTIHVYYDQTMSQR....... 453
53 -52.700[T] COG5170 Serine/threonine protein phosphatase 2A, regulatory subunit  ali follow..  10  26....ITEADIISAVEFDHTGDYLATGDKGGRVVLFERNHSKKGCYLKSLEIEEKINKIRWCKRTNHFLLSTNDKTIKLWKLYEKNLKVVVYANAHAYHINSISVNSDAETYISAD-DLRINLWNLSISDHSFNIVENMEELTEVITSAEFHPNCNHLMYSSSKGNIKLLDLRQSALCDNPCKL----FEDQEDQDSKSFFSEIISSISDVKFSQNGRYILSRD-YLTLKIWDVMEKAPVKTIPLHDVDKFECTFSGDDKHVLSGSSNNFGIYPTDSSLPGDRGQIVLQADKAAFRARKSAANNVPKLNAVKNNDWRSQPQAAYNKKILHASW----HPFEDSVAIAATNN-LFVFS.............. 461
54 -52.600[I] KOG0301 Phospholipase A2-activating protein (contains WD40 repeats)  ali follow..  11  22SHVIEAHKSDTKALAVTQGGC-LISGGRDETVKFWAKKGKQYKTHAFEQPKGITVNSIAYAEDGWRLFVGRRDGTIAVFGPSQA--EPYAIFNEHKQNVCCLHINEKATHMLSGSWDSNVIIWPITELNSSSFTTIVCPGHTLSVWALASFPDLNTYLSASADKTIRMWFGDT----------------------TLSVFKGHTDVVRALVVLSSSH-FLSAGNDGHIIHWDVASASILRKFATQAHEFIYSMTLSDSHILTTGEDGTLEFWAIDGGKDGNL------------------------------AIVSEAVIQLPTTNTWDAKVLLNSD-----IAVAGSDGRIYIMTTDKNRKA....... 327
55 -52.500[R] KOG4497 Uncharacterized conserved protein WDR8, contains WD repeats  ali follow..  10  41ILQLYTCLDQIQHIEWSADSLFILCAMYKRLVQVWSLEQPEW--HCKIDEGSAGLVASCWSPDGRHILNTTEHLRITVWSLCTKS---VSYIKYPKACLQGITFTRDGRYMALAERRDCVSIFVCSDWQ----LLRHFDTDTQDLTGIEWAPNGCVLAVWDTCLEYKIL-----------------LYSLDGRLLSTYSAYEWSLGIKSVAWSPSSQFLAVGSYDGKVRILNHVTWKMITEFANPKMGIGMLAFSPDSYFLATRNDNAVWVWDIQKLRLFAVLE-QLSPVRAFQWDPQQPRLAICTGGWSPAGCMSVQVPGEGDFAVLSLCW----HLSGDSMALLSKDHFCLCFLETEAVTACRQLG.. 457
56 -52.300[R] KOG0646 WD40 repeat protein  ali follow..  15  2..................EITVIASSSIDEGIGSWDLKTGT--EQLQFKPCASPAHGLTAVGESSQLSARNTSGSIFYWSWTKPQ---AEVKSYPVEPIKALAANNEGTYLVGGGISGDIYLWEVATGK----LLKKWHGHYRSVTCLVFSGDDSLLVSGSQDGSIRVWSLIRLFDDFQRQQ---------GNTLYEHNFNEHTMSVTDIVIDYGGCVIISSSEDRTCKVWSLSRGKLLKNI-IFPSVINALALDPGGCVFYAGADSKIYIGAINATS--------------------------------EYGTQVLGSVSEKGKAITCLAY----CADGNLLISGSEDGVVCVWDPKSLRHV....... 298
57 -51.800[BL] KOG1009 Chromatin assembly complex 1 subunit B/CAC2 (contains WD40 repeats)  ali follow..  14  6CEIAWHNKEPVYSLDFQHGTARLASAGVDTNVRIWKVEKGP-EFLSNLARHTKAVNVVRFSPTGEILASGGDDAVILLWKVNDNNWTVVKTLRGHLEDVYDICWATDGNLMASASVDNTAIIWDVSKGQ----KISIFNEHKSYVQGVTWDPLGQYVATLSCDRVLRVYSIQKKRVAFNSKMLSGIGAEGEARSYRMFHDDSMKSFFRRLSFTPDGSLLLTPAGCVESGENVMNTKRPIAHLPCPGKATLAVRCCPYRLVFAVASEDSVLLYDTQQSFPF------------------------------------GYVSNIHYHTLSDISW----SSDGAFLAISSTDGYCSFVTFEKDE......... 379
58 -51.400[R] KOG2055 WD40 repeat protein  ali follow..  12  210ANFQAPSHSGIRCMSIHPYFPLLLTCGFDRTLRIYQLDGKVNPLVTSLHLRSSALQTALFHPDGKRVIAAGRRKYMYIWDLESAQVQKVSRQENFQPSMERFHVDPTGKYIALEGRSGHINLLHALTGQ-----FATSFKIEGVLSDVLFTSDGSEMLVLSYGAEVWHFNVEQRSVVRR--------------------QVQDGVSTTHFCLDPSNKYLAIGSKSGIVNIYDLQTSKPVTTLDNITFSINSMSFSQDSQVLAIASKDTLRLVHVPSFSVFRNWP----------------------------------TSATPLGRVTCLAFGKGG-----ELCVGNEAGRVGLWKLAHYDLK....... 521
59 -51.300[R] KOG2394 WD40 protein DMR-N9  ali follow..  11  127SFAASNSNTSMTNTNFDGKGTYLVFNVSD-AIFICDLNSQEKDPVKSIHFSNSNPMCHAFAKDGHDLLIGLNSGDVYTVSLRQQHYNKDGSVNNRQDRCTSISWVPSTFPAIRDPTQFSVDKAKYSKSN----PVARWHICQGSINSIAFSNDGAHLATVGRDGYLRIFDFLTQKL--------------------VCGGKSYYGALLCCSWSMDGKYILTGGEDDLVQVWSMEDRKVVAWGEGHNSWVSGVAFDSNWSFGSVGQDTQLLLWDLEMDEIVVPLRRAPGGSPTYSTGSSAHWDNVIPMGRDVPKLSPIIAHRVHTEPLSGLMFTQES------VVTACREGHIKIWTRPSESET....... 518
60 -51.100[T] KOG1354 Serine/threonine protein phosphatase 2A, regulatory subunit  ali follow..  11  21VDDDVAEADIISTVEFNHSGELLATGDKGGRVVIFQQEQENKIQSHSRGEYNVYSTFQSHEPEFDYLKSLEIEEKIN-WLPQKNASPRRIFANAHTYHINSISINSDYETYLSAD-DLRINLWHLEITDR--IKPANMEELTEVITAAEFHPNSNTFVYSSSKGTIRLCDMRASALCDRHSKLFEEPEDP----SNRSFFSEIISSISDVKFSHSGRYMMTRD-YLSVKIWDLMENRPVETYQVHEYDKFECCWNGSDSVVMTGSNNFFRMFDRNTKRDITLEASRENNKPRTVLKPRKVCASGKRKKDEISVDS------DFNKKILHTAW----HPKENIIAVATTNN-LYIFQDKV........... 446
61 -51.000[DK] KOG0973 Histone transcription regulator HIRA, WD repeat superfamily  ali follow..  12  2..TFVGHDGSILAIDCHPSGKKFITCTSNGLVVVWNAENENVPKLLFQVESQSQSNSCRWSPDGKRFAFGSDDSSVSVWEYVGLRYKECCVLRGHSMEVLTVEWSPNGKYLASGSIDYRIIIYNARKLPD---RITVLNDIQLPVKGLSWDPIGKYLASLEGDKKLRFWATDSWQCVK--------------SVTEPFESNIEETMLTRLDWSPDGKYLMTPAAVRLIKLIQRQTWKSDQFLAGHHKGTTCVRAMPRTCAAVGSRDKSISIWVFPGT-------------------------------------LKPLFVINNIFNHTVMDF----AWCGRNLLACSQDGTVKVIHLSESV......... 350
62 -50.800[S] KOG0281 Beta-TrCP (transducin repeats containing)/Slimb proteins  ali follow..  17  199IQCRSENSKGV--YCLQYDDEKIISGLRDNSIKIWDKTSLE--CLKVLTGHTGSVLCLQY--DERVIVTGSSDSTVRVWDVNTG--EVLNTLIHHNEAVLHLRFSNGL--MVTCSKDRSIAVWDMASATD--TLRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWSTSTCE--------------------FVRTLNGHKRGIACLQY--RDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNK-RIVSGAYDGKIKVWDLQA----------------------------ALDPRAPASTLCLRTLVEHSGRVFRLQF------DEFQIISSSHDDTILIWDFLNVPPS....... 491
63 -50.700[R] KOG0288 WD40 repeat protein TipD  ali follow..  10  181EEMLAKLKANGLETLARQQVDGIVRRNEDGTDHFVESTIPS-TCANRIHAHEGGCGSIVFEYNSGTLFTGGQDRAVKMWDTNSGT--LIKSLYGSLGNILDMAVTHDNKSVIAATSSNNLFVWDVSSGR----VRHTLTGHTDKVCAVDVSKFSRHVVSAAYDRTIKLWDLHKGYC---------------------TNTVLFTSNCNAICLSIDGLTVFSGHMDGNLRLWDIQTGKLLSEVAGHSSAVTSVSLSRNGNILTSGRDNVHNVFDTRTLEICGTLRASGSNWSRSCISPDDDYVAAGSADWSLSKGNIVSILKEQTSPILCCSW----SGIGKPLASADKNGYVCTWT.............. 515
64 -50.700[E] KOG0280 Uncharacterized conserved protein  ali follow..  13.....YTDWPADVCKYSQVFEDVLVVG---TYMLDESTKLRHGKLV----LYDTKEDVLSPHDASVLAVAHSTGHVSFYRHQFRAELMFLKVADSSVLMLSLDFSDSGKELAVSMSNGSVLIIDIDSGV----IKNKWKEHDYEAWTCHYSRDNNLLYSGGDDAALVCYDQRIPN-----------------SCIWRDIQVHHSGVVSILSRAPFGPYIATGEYGDFMHTLDTRNIGKPLFSANLGGGVWRLEHMETTEVLGILMHRGAQVLRISNDF--------------------------------SSIDASKRIFKEHESMCYGGDW----RHTDGLLATCSYDKRVCLWED............. 309
65 -50.700[DO] KOG0305 Anaphase promoting complex, Cdc20, Cdh1, and Ama1 subunits  ali follow..  120.APGLRDDFSLNLLDWGSANVLAI--ALGDTVYLWDASSGSTSELVTIDEDKGPVTSINWTQDGLDLAVGLDNSEVQLWDCVSNR---QVRTLRGGHESRVGSLAWDNHILTTGGMDGKIVNNDVRIRSS---IVETYLGHTEEVCGLKWSESGNKQASGGNDNVVHIWDRSLAS--------------SKQTRQWLHRFEEHTAAVRALAWCPFQASLLATGGDGKIKFWNTHTGACLNSVETGSQ-VCSLLWSQSERELLSSHQNQLTLWKYPSMSKMAEL-------------------------------------NGHTSRVLFMAQ----SPNGCTVASAAGDENLRLWNVFGEPPK....... 423
66 -50.400[R] KOG1539 WD repeat protein  ali follow..  181LYQFKGWGSSVTSCVSSPALDVVAIGCADGKIHVHNIKLDE-EIVTFEHASRGAVTALSFSTDGRLLASGGSFGVISIWNLNKKRLQSVIR-DAHDSSIISLNFLANEPVLMSASADNSLKMWIFDTNDGDPRLLRFRSGHSAPPLCIRFYSNGRHILSAGQDRAFRLFSVIQEQLSQRHISRRAKKLRLKEEELKLVSRNHLLLAILACAISACGNFAVVGTAGGWIERFNLQSGISRGSYYAHDGEVIGVACDSTNTLMISAGHGDLKVWDFKKRELKSQWD-VGCSLVKIVYHRVNGLLATVADDYDVVTLKMVREFRGHTDRITDLCF----SEDGKWVISSSMDGSLRIWDVILAKQI....... 613
67 -50.300[S] KOG0294 WD40 repeat-containing protein  ali follow..  11  2.................PPEMEIIEATNEELLLGFKLIKSKFELKQTFADSSYARSITSLAVQWPWVASGGTDGRIFVYDMRTR--KQSQIILSHAGRVNTLKFTPDLSLLLSGSDDGHMIATRVGSWT---KEYDWQKAHAGQVTHVSCHPSSKLALSLGGDQVLNTWNLVNGCVAHK---------------TNLKNKATLDFQTGCLSWSKQGDHFTLSG-PLVLEIWGIENAHVMRRIE-MPSKPICITWLDGNECLTGLDNGNIAWISLKDED-----------------------------------DTPPTFILAHEVRVKAIAY------LNEFLATVSIAGQIKVWKIDMETRKLEEI... 298
68 -50.300[S] KOG2106 Uncharacterized conserved protein, contains HELP and WD40 domains  ali follow..  13  166QRHYAGHNDDVKCLAVHPDRITIATGQVAGTVRIWDSVTLNTLHVIGIGFFDRAVTCIAFSNGGTNLCAVDNDHVLSVWDWQKEE--KLADVKCSNEAVFAADFHPTDTNIIVTCGEITSLLLDTRRKGTNRISYAVQGAHEGGISPLCMLRDGTLVSGGGKDRKLISWSGNYQKLIPEQFGPIRTVAEGKGDVILTPITQGHTDELWGLAIHASKPQFLTCGHDKHATLWDAVGHRPVWD-KIIEDPAQSSGFHPSGSVVAVGLTGRWFVFDTETKDLVTVHTDGNEQLSVMRYSPDGNFLAIGSHDNCIRKYTRVGKCSGHSSFITHLDW----SVNSQFLVSNSGDYEILYWVPSACKQVVS..... 611
69 -50.300[R] KOG1273 WD40 repeat protein  ali follow..  12  18..EEYLEHGVIKCVAFNHRGSLLAAGCADGGCVIWDFETRGIAKEIRDNDCSAAITSVSWSKYGHRLLVSAADKSLTLWDVSTGE-RSKCPESNPPFSPAAACFNKCGDLVYIGNSKGEILIVDYKSVR---VLALVSASGAAPVKNIVFSRNGQYLLTNSHDRTIRIYENLLPAKNKMKT-----VGSKCLTLFREFQDSVTKMHWKAPCFSGDGEWVVGGSGEHKIYIWD-RAGHLVKILEGPKEALIDLAWHPVHPIIVSSLAGLVYIWAKDYTENWSAFAPDKELEENEEYVEREDEFDLIPETLDVNEDEEVDIDTVEKDAFSDSDM----SVEELRYLPAEPIPDT.................. 426
70 -50.100[S] KOG2110 Uncharacterized conserved protein, contains WD40 repeats  ali follow..  3..........FFVRKYRGKAALLSIGTFDG-YKIYNCDPFG--KCFHKIQGATSIVEMLFSTSLVALVEKDDGNNRKLKLINTKKSTTICEL-TFPTPLLAVKLNRKRLLAVL---EEQIYVYDISNSPNSENCYLAYPDSRDHEPRTEGESSSPNVSNSAVSGQVILWDVINCK--------------------QITKIEAHKDSLACLAFNSDGTMLATASDNGRIRVFAIPSGQRLYQFRSLPAQIYSIAFHPDSSLLTVTSSQTVHIFRLKEVYSNLERQGLLPSSPPPKESLLRRSSRSLIGTVGGPERDFAYAHIPGDKVTSIAAF----GPDNTIVNVATYDGNLYSFRVNLRT......... 356
71 -49.900[A] KOG0284 Polyadenylation factor I complex, subunit PFS2  ali follow..  13  84NRLWQYGKQRILQQPDILYQQYAVPADSTPDVPVDCILTK--FIRTAMNKVKCPVYSVCWSPEGKRLITGCQTGEFTLWNGTAFN--FETILQAHDSAIRALKWASNEQWLLSADQGGYVKYWQPNMNN----AHMFSAHKDEAIRGLAFAPTDVKFATASDDGTARVWDFARYT--------------------EERVLRGHGAEVRCIDWHPTKGLIATGSRDTPVKIWDPKSGSCLATLQEHKSSVMAVEFNKNGNWLLTGGDHLVKMYDIRMMKEMRTYRAHKKEVISLAWHPIHEGLFVSGGGMVDGEKEIGLLEHAHDQAIWSMKW----HPLGHILATGSNDNNTKFWARNRPGDTVEDI... 428
72 -49.800[A] KOG0272 U4/U6 small nuclear ribonucleoprotein Prp4 (contains WD40 repeats)  ali follow..  17  254LCSQVGDTRPVSSAAFSEDSSLLLTSSWSGLCKLWSVPDCE--LKQTLRGHASYVGGVALRPGVKAMASGGHDGAVKLWGFNNEE--SIADITGHPHRVSKVAFHPSGRFLATACYDSSWRLWDLEQKT----EVLHQEGHAKPVHCLSYHSDGSVLVTGGLDAFGRVWDLRTGR--------------------CIMFLEGHLGAVFGVDFSPNGFHIATGSQDNTCKIWDLRRRQPVYTIPAHTNLISDVKYQQECFLVTCSYDSTTKIWSNKTWQPLKTL-------------------------------------QGHDNKVISVDI----APNSQYIATTSFDRTFKLWSPDS........... 553
73 -49.800[R] KOG2444 WD40 repeat protein  ali follow..  11  1..MLVEFDNPPLCMKSNKDGSRLVVGFVDGSIRFYDTQQHEEEFQEIKFQTKSSIRGVDLDEHKKRVYAVTKNRSLCVFDIDTGK-RVRCILKCHRSVPTAICTLPKSQQLATADESGEVKTWNLDPEVSENANIRKWQEQDEDINDLKVDVKSNLLATSS-DGTLGAYDLRKAKL--------------------KMRSELMHSEL--YSVCGTNRSVYVGGEDGYVEVFNLNEYGNLRVESGFEMGVNGIVELRSGLLGLTSQSNRMRLLNVQPSKRLGYAGYHGD-------------------------------EKSDDDGIDAITISTDKS---TVFTMISMSCTIKKWDMGPIIDEIPILR.. 317
74 -49.600[R] KOG2321 WD40 repeat protein  ali follow..  51.....EYPEASNRIKCTRDGKYAMATGYKPHIKVFDFAEMS--LKFERHTDAENVQFEILSDDWTKSVHLQTDRTVDFHSQGGIHYS-----TRIPKYGRDLKYHYPNCDLYLAAAGDEVYRLNLEQGRPLKIESAQIDSPTGGVNVIDINPMHQLLAFGTDAGSVEFWDPRDRS----------VGILEIPSTVPSTPYSDNSRSVTALKYRNDGLNVAIGLSDGATLLYDLRSSSPYMSDQGYSMPIKSLHWMDSALRVLSADSKIIKIWEKDTGKPFSSIE-PTVELNDVCPIEGTGLILTANEGSPMSLNPAPRWCSFLDNITEEMEENPAPIYDDYKFVTKKELLNLGLDHLVGTGVIRAYMH.. 412
75 -49.600[U] KOG0771 Prolactin regulatory element-binding protein/Protein transport protein SEC12p  ali follow..  8PSNLQTYGVPIYAVDWILEEAVRSKITKDQDDDDDDGSSSS-QPIGRRVIGTDLPYRMAIHPRQGGLICAL-PNSCRLFDWENEESEKVVKELKDVGQQLSLSFNQDGTVLATGAEDGTLRVFEWPSMK----TLLNESKTHASVKSLTFSESGKFLVSLG-APLCRVWDVNASAAIASLS-------------------KEKDEMFASCRFSVDNSVAANTQRGGSIITWDTTSWRRRSSLIKRNNSISAFNVSADGKLLAVGTEGDVLIIDSTKMQTNQI------------------------------------VKKAHLGLVTALTF----SPDSRCLVSVSFDSRARLTVIKQKGEKRRVY... 357

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Zhao Y, Hong DH, Pawlyk B, Yue G, Adamian M, Grynberg M, Godzik A., Li T. The retinitis pigmentosa GTPase regulator (RPGR)- interacting protein: subserving RPGR function and participating in disk morphogenesis. Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):3965-70. Epub 2003 Mar 21.